Publication Date:
1994-08-05
Description:
The microinjection of messenger RNA encoding the eukaryotic translation initiation factor 4E (eIF-4E) into early embryos of Xenopus laevis leads to the induction of mesoderm in ectodermal explants. This induction occurs without a stimulation of overall protein synthesis and is blocked by the co-expression of a dominant negative mutant of the proto-oncogene ras or a truncated activin type II receptor. Although other translation factors have been studied in vertebrate and invertebrate embryos, none have been shown to play a direct role in development. The results here suggest a mechanism for relaying and amplifying signals for mesoderm induction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, P S -- Melton, D A -- New York, N.Y. -- Science. 1994 Aug 5;265(5173):803-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8047887" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Eukaryotic Initiation Factor-1/physiology
;
Eukaryotic Initiation Factor-4E
;
Gene Expression Regulation/physiology
;
Mesoderm/metabolism/*physiology
;
Molecular Sequence Data
;
Peptide Initiation Factors/genetics/*physiology
;
RNA, Messenger
;
Xenopus laevis/*embryology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
