Publication Date:
1994-05-13
Description:
Many tumors express tumor-specific antigens capable of being presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules. Antigen presentation models predict that the tumor cell itself should present these antigens to T cells. However, when conditions for the priming of tumor-specific responses were examined in mice, no detectable presentation of MHC class I-restricted tumor antigens by the tumor itself was found. Rather, tumor antigens were exclusively presented by host bone marrow-derived cells. Thus, MHC class I-restricted antigens are efficiently transferred in vivo to bone marrow-derived antigen-presenting cells, which suggests that human leukocyte antigen matching may be less critical in the application of tumor vaccines than previously thought.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, A Y -- Golumbek, P -- Ahmadzadeh, M -- Jaffee, E -- Pardoll, D -- Levitsky, H -- New York, N.Y. -- Science. 1994 May 13;264(5161):961-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7513904" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Presenting Cells/*immunology
;
Antigens, Neoplasm/*immunology
;
Bone Marrow/immunology
;
Bone Marrow Cells
;
Colonic Neoplasms/immunology
;
Epitopes
;
Female
;
Granulocyte-Macrophage Colony-Stimulating Factor/genetics/immunology
;
H-2 Antigens/immunology
;
Histocompatibility Antigens Class I/*immunology
;
Melanoma, Experimental/immunology
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Nucleocapsid Proteins
;
*Nucleoproteins
;
T-Lymphocytes, Cytotoxic/*immunology
;
Tumor Cells, Cultured
;
Viral Core Proteins/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
