Publication Date:
1989-04-07
Description:
Developing Retzius (Rz) neurons in different segments of the central nervous system of the medicinal leech have different peripheral targets: Rz cells in standard segments innervate the body wall, whereas Rz cells in the reproductive segments innervate reproductive tissue. Early removal of reproductive tissue primordia causes reproductive Rz cells to develop morphologically like their standard segmental homologs, suggesting that Rz cells depend on peripheral targets for signals that determine their central and peripheral morphology. Furthermore, after removal of reproductive tissue, reproductive Rz cells also receive synaptic inputs normally appropriate for standard Rz cells. These results suggest that the functional identity of these neurons is specified by the target they contact during embryogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loer, C M -- Kristan, W B Jr -- GM07313/GM/NIGMS NIH HHS/ -- NS20746/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1989 Apr 7;244(4900):64-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, San Diego, La Jolla 92093.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2704990" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Central Nervous System/physiology
;
Embryo, Nonmammalian/physiology
;
Ganglia/physiology
;
Leeches/growth & development/*physiology
;
Neurons/physiology
;
Synapses/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
