Publication Date:
1989-09-15
Description:
The neutrophil Mac-1 and gp100MEL-14 adhesion proteins are involved in neutrophil extravasation during inflammation. Both the expression and activity of Mac-1 are greatly increased after neutrophil activation. In contrast, neutrophils shed gp100MEL-14 from the cell surface within 4 minutes after activation with chemotactic factors or phorbol esters, releasing a 96-kilodalton fragment of the antigen into the supernatant. Immunohistology showed that gp100MEL-14 was downregulated on neutrophils that had extravasated into inflamed tissue. The gp100MEL-14 adhesion protein may participate in the binding of unactivated neutrophils to the endothelium; rapid shedding of gp100MEL-14 may prevent extravasation into and damage of normal tissues by activated neutrophils.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kishimoto, T K -- Jutila, M A -- Berg, E L -- Butcher, E C -- AI 19957/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1989 Sep 15;245(4923):1238-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Stanford University, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2551036" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Differentiation/*immunology
;
Antigens, Surface/*immunology
;
Bone Marrow Cells
;
Cell Adhesion
;
Cell Adhesion Molecules
;
Chemotactic Factors/*physiology
;
Complement C5/physiology
;
Complement C5a
;
Fluorescent Antibody Technique
;
Interleukin-1/physiology
;
Interleukin-8
;
Kinetics
;
Leukotriene B4/physiology
;
Lipopolysaccharides/physiology
;
Lymphocyte Activation
;
Macrophage Activation
;
Macrophage-1 Antigen
;
Mice
;
Mice, Inbred BALB C
;
Neutrophils/cytology/*immunology
;
Tetradecanoylphorbol Acetate
;
Tumor Necrosis Factor-alpha/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
