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  • 1
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    Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-09-15
    Description: The neutrophil Mac-1 and gp100MEL-14 adhesion proteins are involved in neutrophil extravasation during inflammation. Both the expression and activity of Mac-1 are greatly increased after neutrophil activation. In contrast, neutrophils shed gp100MEL-14 from the cell surface within 4 minutes after activation with chemotactic factors or phorbol esters, releasing a 96-kilodalton fragment of the antigen into the supernatant. Immunohistology showed that gp100MEL-14 was downregulated on neutrophils that had extravasated into inflamed tissue. The gp100MEL-14 adhesion protein may participate in the binding of unactivated neutrophils to the endothelium; rapid shedding of gp100MEL-14 may prevent extravasation into and damage of normal tissues by activated neutrophils.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kishimoto, T K -- Jutila, M A -- Berg, E L -- Butcher, E C -- AI 19957/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1989 Sep 15;245(4923):1238-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Stanford University, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2551036" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Differentiation/*immunology ; Antigens, Surface/*immunology ; Bone Marrow Cells ; Cell Adhesion ; Cell Adhesion Molecules ; Chemotactic Factors/*physiology ; Complement C5/physiology ; Complement C5a ; Fluorescent Antibody Technique ; Interleukin-1/physiology ; Interleukin-8 ; Kinetics ; Leukotriene B4/physiology ; Lipopolysaccharides/physiology ; Lymphocyte Activation ; Macrophage Activation ; Macrophage-1 Antigen ; Mice ; Mice, Inbred BALB C ; Neutrophils/cytology/*immunology ; Tetradecanoylphorbol Acetate ; Tumor Necrosis Factor-alpha/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Chemokines and the arrest of lymphocytes rolling under flow conditions (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-02-07
    Description: Circulating lymphocytes are recruited from the blood to the tissue by rolling along the endothelium until being stopped by a signaling event linked to the Gialpha subunit of a heterotrimeric GTP-binding protein; that event then triggers rapid integrin-dependent adhesion. Four chemokines are now shown to induce such adhesion to intercellular adhesion molecule-1 and to induce arrest of rolling cells within 1 second under flow conditions similar to those of blood. SDF-1 (also called PBSF), 6-C-kine (also called Exodus-2), and MIP-3beta (also called ELC or Exodus-3) induced adhesion of most circulating lymphocytes, including most CD4+ T cells; and MIP-3alpha (also called LARC or Exodus-1) triggered adhesion of memory, but not naive, CD4+ T cells. Thus, chemokines can regulate the arrest of lymphocyte subsets under flowing conditions, which may allow them to control lymphocyte-endothelial cell recognition and lymphocyte recruitment in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Campbell, J J -- Hedrick, J -- Zlotnik, A -- Siani, M A -- Thompson, D A -- Butcher, E C -- 5T32CA090302/CA/NCI NIH HHS/ -- DK38707/DK/NIDDK NIH HHS/ -- GM37734/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1998 Jan 16;279(5349):381-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunology and Vascular Biology, Department of Pathology, and Digestive Disease Center, Department of Medicine, Stanford University Medical School, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9430588" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/metabolism ; CD4-Positive T-Lymphocytes/*physiology ; *Cell Adhesion ; Chemokine CCL19 ; Chemokine CCL20 ; Chemokine CCL21 ; Chemokine CXCL12 ; Chemokines, CC/*pharmacology/physiology ; *Chemokines, CXC ; Humans ; Immunologic Memory ; Intercellular Adhesion Molecule-1/metabolism ; Lymphocytes/*physiology ; *Macrophage Inflammatory Proteins ; Membrane Proteins ; Receptors, CCR6 ; *Receptors, Chemokine ; Rheology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Lymphocyte homing and homeostasis (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-04-05
    Description: The integration and control of systemic immune responses depends on the regulated trafficking of lymphocytes. This lymphocyte "homing" process disperses the immunologic repertoire, directs lymphocyte subsets to the specialized microenvironments that control their differentiation and regulate their survival, and targets immune effector cells to sites of antigenic or microbial invasion. Recent advances reveal that the exquisite specificity of lymphocyte homing is determined by combinatorial "decision processes" involving multistep sequential engagement of adhesion and signaling receptors. These homing-related interactions are seamlessly integrated into the overall interaction of the lymphocyte with its environment and participate directly in the control of lymphocyte function, life-span, and population dynamics. In this article a review of the molecular basis of lymphocyte homing is presented, and mechanisms by which homing physiology regulated the homeostasis of immunologic resources are proposed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butcher, E C -- Picker, L J -- New York, N.Y. -- Science. 1996 Apr 5;272(5258):60-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, CA 94305-5324, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8600538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens/immunology ; B-Lymphocytes/*immunology/physiology ; Blood Vessels/physiology ; Cell Adhesion ; Cell Movement ; Chemokines/physiology ; Endothelium, Vascular/cytology/physiology ; Homeostasis ; Humans ; Lymphoid Tissue/immunology ; Receptors, Lymphocyte Homing/*physiology ; T-Lymphocytes/*immunology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Role of Rho in chemoattractant-activated leukocyte adhesion through integrins (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-02-16
    Description: Heterotrimeric guanine nucleotide binding protein (G protein)-linked receptors of the chemoattractant subfamily can trigger adhesion through leukocyte integrins, and in this role they are thought to regulate immune cell-cell interactions and trafficking. In lymphoid cells transfected with formyl peptide or interleukin-8 receptors, agonist stimulation activated nucleotide exchange on the small guanosine triphosphate-binding protein RhoA in seconds. Inactivation of Rho by C3 transferase exoenzyme blocked agonist-induced lymphocyte alpha4beta1 adhesion to vascular cell adhesion molecule-1 and neutrophil beta2 integrin adhesion to fibrinogen. These findings suggest that Rho participates in signaling from chemoattractant receptors to trigger rapid adhesion in leukocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Laudanna, C -- Campbell, J J -- Butcher, E C -- 1F32 AI08930/AI/NIAID NIH HHS/ -- 5T32 CA09302/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Feb 16;271(5251):981-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8584934" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigens, CD/genetics ; B-Lymphocytes/*physiology ; *Cell Adhesion ; Cells, Cultured ; Chemotactic Factors/*pharmacology ; GTP-Binding Proteins/metabolism/*physiology ; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism ; Guanosine Diphosphate/metabolism ; Integrin alpha4beta1 ; Integrins/*physiology ; Interleukin-8/pharmacology ; Mice ; Molecular Sequence Data ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Receptors, Formyl Peptide ; Receptors, Immunologic/genetics ; Receptors, Interleukin/genetics ; Receptors, Interleukin-8A ; Receptors, Lymphocyte Homing/*physiology ; Receptors, Peptide/genetics ; Signal Transduction ; Tetradecanoylphorbol Acetate/pharmacology ; Transfection ; Vascular Cell Adhesion Molecule-1/*physiology ; rhoA GTP-Binding Protein
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    A distinct endothelial cell recognition system that controls lymphocyte traffic into inflamed synovium (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-01
    Description: Lymphocytes are essential mediators of normal tissue inflammatory reactions and of pathologic tissue damage in, for example, rheumatoid arthritis and other autoimmune diseases. In a study of the mechanisms controlling lymphocyte entry into sites of inflammation from the blood, the function and specificity of lymphocyte-endothelial interactions were examined in inflamed joint tissue (synovium) from patients with rheumatoid arthritis. Synovial high endothelial venules (HEV) supported the binding of normal peripheral blood lymphocytes in vitro. The characteristics of this binding, which were similar to those of lymphocyte-HEV interactions controlling lymphocyte migration into organized lymphoid tissues, included a requirement for calcium ions, a dependence on metabolic activity, and a preferential adherence of circulating lymphocytes as opposed to immature thymocytes. However, the binding of lymphocytes to synovial HEV was not inhibited by a monoclonal antibody to lymphocyte receptors for lymph node HEV, and synovial HEV failed to bind either lymph node HEV-specific or mucosal HEV-specific B lymphoblastoid cells. The results suggest that a lymphocyte-endothelial cell recognition system that is distinct from such systems in organized lymphoid tissues directs the extravasation of normal lymphocytes as well as pathologically important effector cells into inflamed synovium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jalkanen, S -- Steere, A C -- Fox, R I -- Butcher, E C -- AI19957/AI/NIAID NIH HHS/ -- AM-20358/AM/NIADDK NIH HHS/ -- RR-00125/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1986 Aug 1;233(4763):556-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3726548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthritis, Rheumatoid/immunology ; Endothelium/immunology ; Humans ; Immunity, Cellular ; Lymph Nodes/cytology ; Lymphocytes/immunology/*physiology ; Mice ; Synovial Membrane/immunology ; Synovitis/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
    Electronic Resource
    Electronic Resource
    AbnormalSq behaviour (1989)
    Springer
    Pure and applied geophysics 131 (1989), S. 463-483 
    Details
    ISSN: 1420-9136
    Keywords: Abnormal quiet days ; Sq(H)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract It is well-known that the amplitude and phase of theSq(H) variation show considerable variability from day to day. In this paper we consider one aspect of the phase variability—that associated with AQDs. AQDs (or “abnormal quiet days”) are defined as magnetically quiet days where the maximum excursion ofH at a mid-latitude station on the poleward side of the focus occurs outside the “normal” time range 0830–1330 LST. Such days exhibit properties, many of which appear quite distinct from the properties of the “normal”Sq(H) variation. The properties of AQDs, and the proposals that have been made to explain them, are considered in detail. The consequences of these proposals and some problems which need to be addressed in order to obtain a fuller understanding of the dynamics of the ionosphere on AQDs are also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00876840
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  • 7
    Electronic Resource
    Electronic Resource
    The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 400 (1999), S. 776-780 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Lymphocytes that are responsible for regional (tissue-specific) immunity home from the blood to the intestines, inflamed skin or other sites through a multistep process involving recognition of vascular endothelial cells and extravasation. Chemoattractant cytokine molecules known as chemokines ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/23495
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  • 8
    Electronic Resource
    Electronic Resource
    A Worldwide Study of the H, D and Z Variation On Abnormal Quiet Days (Aqds) (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 114 (1993), S. 0 
    Details
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: An extensive analysis, using 80 stations, has been made of the latitudinal and longitudinal variation of the additional fields in H, D and Z that occurred on Abnormal Quiet Days (AQDs) during the Northern Hemisphere winter months in the years 1964-65. This analysis shows that the additional fields occurring on AQDs may be represented by a single-current vortex (SCV) that has a focus in the latitude range 15-20°N for the Northern Hemisphere winter AQDs. the evidence strongly suggests that the most likely location of the SCV is the ionosphere, although no further insight into what drives it is forthcoming.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-246X.1993.tb01477.x
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  • 9
    Electronic Resource
    Electronic Resource
    Seasonal and sunspot-cycle changes in the day-to-day variability of Sq (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 120 (1995), S. 0 
    Details
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: A study has been made of seasonal and sunspot-cycle changes in the day-to-day variability of Sq, using data from magnetic observatories for which long runs exist. For sunspot-cycle changes, the absolute variability, as measured by the standard deviation (sd) of the range, increases from sunspot minimum to sunspot maximum. However, the ratio of sd to range, arguably a more meaningful parameter physically, is generally smaller at sunspot maximum than sunspot minimum. This is interpreted to show that the fractional variability in dynamo winds is less at sunspot maximum than sunspot minimum. The seasonal changes of variability show consistent global patterns, including an interesting hemispheric asymmetry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-246X.1995.tb05919.x
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  • 10
    Electronic Resource
    Electronic Resource
    The annual variation of the night-time values of the geomagnetic field (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 111 (1992), S. 0 
    Details
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: In this paper we present the results of an analysis of the variation of period of one year in night-time H data. The analysis indicates that this annual variation comprises of two components. (1) A component whose amplitude depends on latitude and is of opposite phase in the two hemispheres. This component is assumed to be due to the change of the latitude of the ring current caused by the solar wind, as originally proposed by Malin & Isikara (1976). (2) A smaller component which, in a given year, has an amplitude and phase that is approximately the same at all latitudes but which may change from year to year. Its origin is not known but it is suggested that it may be found in the modulation of a distant current, such as the cross-tail current of the night-time magnetosphere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-246X.1992.tb00561.x
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