Publication Date:
1992-08-07
Description:
Immune responses in lymphocytes require cellular accumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca(2+)-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khan, A A -- Steiner, J P -- Klein, M G -- Schneider, M F -- Snyder, S H -- DA-00074/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- P01-HL27867/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 Aug 7;257(5071):815-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1323146" target="_blank"〉PubMed〈/a〉
Keywords:
Antigens, CD/metabolism
;
Antigens, CD3
;
Antigens, Differentiation, T-Lymphocyte/analysis/*metabolism
;
Burkitt Lymphoma
;
Calcium/*metabolism
;
*Calcium Channels
;
Cell Line
;
Cell Membrane/*metabolism
;
Cells, Cultured
;
Concanavalin A/pharmacology
;
Fluorescent Antibody Technique
;
Humans
;
Inositol 1,4,5-Trisphosphate/*metabolism
;
Inositol 1,4,5-Trisphosphate Receptors
;
Kinetics
;
Receptors, Antigen, T-Cell/analysis/*metabolism
;
Receptors, Cell Surface/analysis/*metabolism
;
*Receptors, Cytoplasmic and Nuclear
;
Second Messenger Systems
;
T-Lymphocytes/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
