Publication Date:
2015-09-26
Description:
Dying cells initiate adaptive immunity by providing both antigens and inflammatory stimuli for dendritic cells, which in turn activate CD8(+) T cells through a process called antigen cross-priming. To define how different forms of programmed cell death influence immunity, we established models of necroptosis and apoptosis, in which dying cells are generated by receptor-interacting protein kinase-3 and caspase-8 dimerization, respectively. We found that the release of inflammatory mediators, such as damage-associated molecular patterns, by dying cells was not sufficient for CD8(+) T cell cross-priming. Instead, robust cross-priming required receptor-interacting protein kinase-1 (RIPK1) signaling and nuclear factor kappaB (NF-kappaB)-induced transcription within dying cells. Decoupling NF-kappaB signaling from necroptosis or inflammatory apoptosis reduced priming efficiency and tumor immunity. Our results reveal that coordinated inflammatory and cell death signaling pathways within dying cells orchestrate adaptive immunity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651449/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651449/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yatim, Nader -- Jusforgues-Saklani, Helene -- Orozco, Susana -- Schulz, Oliver -- Barreira da Silva, Rosa -- Reis e Sousa, Caetano -- Green, Douglas R -- Oberst, Andrew -- Albert, Matthew L -- 5R01AI108685-02/AI/NIAID NIH HHS/ -- AI44848/AI/NIAID NIH HHS/ -- R01 AI108685/AI/NIAID NIH HHS/ -- R01AI108685/AI/NIAID NIH HHS/ -- R21 CA185681/CA/NCI NIH HHS/ -- R21CA185681/CA/NCI NIH HHS/ -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2015 Oct 16;350(6258):328-34. doi: 10.1126/science.aad0395. Epub 2015 Sep 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, 25 Rue du Docteur Roux, 75015 Paris, France. Institut National de la Sante et de la Recherche Medicale, U818, 25 Rue du Docteur Roux, 75015 Paris, France. Frontieres du Vivant Doctoral School, Ecole Doctorale 474, Universite Paris Diderot-Paris 7, Sorbonne Paris Cite, 8-10 Rue Charles V, 75004 Paris, France. ; Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, 25 Rue du Docteur Roux, 75015 Paris, France. Institut National de la Sante et de la Recherche Medicale, U818, 25 Rue du Docteur Roux, 75015 Paris, France. ; Department of Immunology, University of Washington, Campus Box 358059, 750 Republican Street, Seattle, WA 98109, USA. ; Immunobiology Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. ; Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26405229" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apoptosis/*immunology
;
CD8-Positive T-Lymphocytes/*immunology
;
Caspase 8/metabolism
;
Cell Survival
;
Cross-Priming
;
Dendritic Cells/immunology
;
Mice
;
Mice, Inbred C57BL
;
NF-kappa B/*metabolism
;
NIH 3T3 Cells
;
Receptor-Interacting Protein Serine-Threonine Kinases/genetics/*metabolism
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
