Publication Date:
2011-08-06
Description:
Formation of myelin, the electrical insulation on axons produced by oligodendrocytes, is controlled by complex cell-cell signaling that regulates oligodendrocyte development and myelin formation on appropriate axons. If electrical activity could stimulate myelin induction, then neurodevelopment and the speed of information transmission through circuits could be modified by neural activity. We find that release of glutamate from synaptic vesicles along axons of mouse dorsal root ganglion neurons in culture promotes myelin induction by stimulating formation of cholesterol-rich signaling domains between oligodendrocytes and axons, and increasing local synthesis of the major protein in the myelin sheath, myelin basic protein, through Fyn kinase-dependent signaling. This axon-oligodendrocyte signaling would promote myelination of electrically active axons to regulate neural development and function according to environmental experience.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482340/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482340/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wake, Hiroaki -- Lee, Philip R -- Fields, R Douglas -- Z99 HD999999/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2011 Sep 16;333(6049):1647-51. doi: 10.1126/science.1206998. Epub 2011 Aug 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nervous System Development and Plasticity Section, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21817014" target="_blank"〉PubMed〈/a〉
Keywords:
*Action Potentials
;
Adenosine Triphosphate/metabolism
;
Animals
;
Axons/*physiology
;
Calcium/metabolism
;
Calcium Signaling
;
Cell Differentiation
;
Cells, Cultured
;
Electric Stimulation
;
Ganglia, Spinal/cytology/embryology
;
Glutamic Acid/metabolism
;
Mice
;
Myelin Basic Protein/*biosynthesis/genetics/metabolism
;
Myelin Sheath/*physiology
;
Neural Stem Cells/cytology/metabolism
;
Oligodendroglia/cytology/*metabolism
;
Proto-Oncogene Proteins c-fyn/metabolism
;
Receptors, Transferrin/metabolism
;
Signal Transduction
;
Synaptic Transmission
;
Synaptic Vesicles/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
