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  • 1
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    Response of Schwann cells to action potentials in development (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-24
    Description: Sensory axons become functional late in development when Schwann cells (SC) stop proliferating and differentiate into distinct phenotypes. We report that impulse activity in premyelinated axons can inhibit proliferation and differentiation of SCs. This neuron-glial signaling is mediated by adenosine triphosphate acting through P2 receptors on SCs and intracellular signaling pathways involving Ca2+, Ca2+/calmodulin kinase, mitogen-activated protein kinase, cyclic adenosine 3',5'-monophosphate response element binding protein, and expression of c-fos and Krox-24. Adenosine triphosphate arrests maturation of SCs in an immature morphological stage and prevents expression of O4, myelin basic protein, and the formation of myelin. Through this mechanism, functional activity in the developing nervous system could delay terminal differentiation of SCs until exposure to appropriate axon-derived signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stevens, B -- Fields, R D -- New York, N.Y. -- Science. 2000 Mar 24;287(5461):2267-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Developmental Neurobiology, National Institutes of Health, National Institute of Child Health and Human Development, Building 49, Room 5A38, 49 Convent Drive, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10731149" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Adenosine Triphosphate/metabolism ; Animals ; Axons/*physiology ; Calcium/metabolism ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Cell Differentiation ; Cell Division ; Cells, Cultured ; Coculture Techniques ; Cyclic AMP Response Element-Binding Protein/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Early Growth Response Protein 1 ; Electric Stimulation ; Ganglia, Spinal/physiology ; Gene Expression Regulation, Developmental ; Genes, fos ; *Immediate-Early Proteins ; Mice ; Microscopy, Confocal ; Myelin Sheath/metabolism ; Neurons, Afferent/*physiology ; Phosphorylation ; Proto-Oncogene Proteins c-fos/metabolism ; Receptors, Purinergic P2/metabolism ; Schwann Cells/*cytology/*physiology ; Signal Transduction ; Transcription Factors/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Synaptic connections in vitro: modulation of number and efficacy by electrical activity (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-05-05
    Description: The functional architecture of synaptic circuits is determined to a crucial degree by the patterns of electrical activity that occur during development. Studies with an in vitro preparation of mammalian sensory neurons projecting to ventral spinal cord neurons slow that electrical activity induces competitive processes that regulate synaptic efficacy so as to favor activated pathways over inactive convergent pathways. At the same time, electrical activity initiates noncompetitive processes that increase the number of axonal connections between these sensory and spinal cord neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson, P G -- Yu, C -- Fields, R D -- Neale, E A -- New York, N.Y. -- Science. 1989 May 5;244(4904):585-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2717942" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Afferent Pathways/physiology ; Animals ; Axons/physiology ; Electric Stimulation ; Ganglia, Spinal/cytology ; Mice ; Neurons/*physiology ; Neurons, Afferent/*physiology ; Spinal Cord/*cytology/embryology ; Synapses/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Neuroscience. The neuron doctrine, redux (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bullock, Theodore H -- Bennett, Michael V L -- Johnston, Daniel -- Josephson, Robert -- Marder, Eve -- Fields, R Douglas -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):791-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scripps Institution of Oceanography and Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272104" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Astrocytes/physiology ; Axons/physiology ; Brain/*physiology ; Cell Communication ; Dendrites/physiology ; Gap Junctions/physiology ; Humans ; *Nervous System Physiological Phenomena ; Neuroglia/physiology ; Neurons/cytology/*physiology ; Neurotransmitter Agents/physiology ; Synapses/physiology ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    New insights into neuron-glia communication (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-19
    Description: Two-way communication between neurons and nonneural cells called glia is essential for axonal conduction, synaptic transmission, and information processing and thus is required for normal functioning of the nervous system during development and throughout adult life. The signals between neurons and glia include ion fluxes, neurotransmitters, cell adhesion molecules, and specialized signaling molecules released from synaptic and nonsynaptic regions of the neuron. In contrast to the serial flow of information along chains of neurons, glia communicate with other glial cells through intracellular waves of calcium and via intercellular diffusion of chemical messengers. By releasing neurotransmitters and other extracellular signaling molecules, glia can affect neuronal excitability and synaptic transmission and perhaps coordinate activity across networks of neurons.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226318/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226318/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fields, R Douglas -- Stevens-Graham, Beth -- Z01 HD000713-11/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 18;298(5593):556-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurocytology and Physiology Section, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. fields@helix.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12386325" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/cytology/physiology ; Brain/cytology/physiology ; *Cell Communication ; Humans ; Microglia/cytology/physiology ; Myelin Sheath/physiology ; Nerve Regeneration ; Nervous System Diseases/pathology/physiopathology ; Neuroglia/*physiology ; Neurons/*physiology ; Neurotransmitter Agents/metabolism ; Oligodendroglia/cytology/physiology ; Schwann Cells/cytology/physiology ; Signal Transduction ; Stem Cells/cytology/physiology ; Synapses/physiology ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    NIH policy: mandate goes too far (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fields, R Douglas -- England -- Nature. 2014 Jun 19;510(7505):340. doi: 10.1038/510340a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24943947" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Experimentation ; Animals ; Biomedical Research/*methods ; Female ; Humans ; Male ; *National Institutes of Health (U.S.) ; *Research Design ; *Sex Characteristics ; *Sex Ratio
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Neuroscience: Map the other brain (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fields, R Douglas -- England -- Nature. 2013 Sep 5;501(7465):25-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nervous System Development and Plasticity Section, US National Institutes of Health in Bethesda, Maryland, USA. fieldsd@mail.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24010144" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/physiology ; Brain/*cytology/*physiology ; *Brain Mapping ; Cerebral Cortex/cytology/physiology ; Humans ; Microglia/physiology ; *Neural Pathways ; Neuroglia/cytology/*physiology ; Neuronal Plasticity ; Neurosciences/*methods/trends ; Oligodendroglia/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Regulated expression of the neural cell adhesion molecule L1 by specific patterns of neural impulses (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-24
    Description: Development of the mammalian nervous system is regulated by neural impulse activity, but the molecular mechanisms are not well understood. If cell recognition molecules [for example, L1 and the neural cell adhesion molecule (NCAM)] were influenced by specific patterns of impulse activity, cell-cell interactions controlling nervous system structure could be regulated by nervous system function at critical stages of development. Low-frequency electrical pulses delivered to mouse sensory neurons in culture (0.1 hertz for 5 days) down-regulated expression of L1 messenger RNA and protein (but not NCAM). Fasciculation of neurites, adhesion of neuroblastoma cells, and the number of Schwann cells on neurites was reduced after 0.1-hertz stimulation, but higher frequencies or stimulation after synaptogenesis were without effect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Itoh, K -- Stevens, B -- Schachner, M -- Fields, R D -- New York, N.Y. -- Science. 1995 Nov 24;270(5240):1369-72.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481827" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/physiology ; Cell Adhesion ; Cells, Cultured ; Down-Regulation ; Electric Stimulation ; Ganglia, Spinal/cytology ; Leukocyte L1 Antigen Complex ; Mice ; Nerve Growth Factors/pharmacology ; Neural Cell Adhesion Molecules/*biosynthesis/genetics ; Neurites/physiology ; Neurons, Afferent/*metabolism/physiology ; RNA, Messenger/genetics/metabolism ; Schwann Cells/physiology ; Spinal Cord/cytology/physiology ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Neuroscience. Change in the brain's white matter (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-06
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201847/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201847/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fields, R Douglas -- New York, N.Y. -- Science. 2010 Nov 5;330(6005):768-9. doi: 10.1126/science.1199139.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nervous Systems Development and Plasticity Section, National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. fieldsd@mail.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21051624" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Axons/physiology ; Brain/*anatomy & histology/*physiology ; Electric Stimulation ; Humans ; *Learning ; Magnetic Resonance Imaging ; *Memory ; Myelin Sheath/*physiology ; Oligodendroglia/physiology ; Stem Cells/physiology ; Synapses ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Control of local protein synthesis and initial events in myelination by action potentials (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-08-06
    Description: Formation of myelin, the electrical insulation on axons produced by oligodendrocytes, is controlled by complex cell-cell signaling that regulates oligodendrocyte development and myelin formation on appropriate axons. If electrical activity could stimulate myelin induction, then neurodevelopment and the speed of information transmission through circuits could be modified by neural activity. We find that release of glutamate from synaptic vesicles along axons of mouse dorsal root ganglion neurons in culture promotes myelin induction by stimulating formation of cholesterol-rich signaling domains between oligodendrocytes and axons, and increasing local synthesis of the major protein in the myelin sheath, myelin basic protein, through Fyn kinase-dependent signaling. This axon-oligodendrocyte signaling would promote myelination of electrically active axons to regulate neural development and function according to environmental experience.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482340/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482340/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wake, Hiroaki -- Lee, Philip R -- Fields, R Douglas -- Z99 HD999999/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2011 Sep 16;333(6049):1647-51. doi: 10.1126/science.1206998. Epub 2011 Aug 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nervous System Development and Plasticity Section, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21817014" target="_blank"〉PubMed〈/a〉
    Keywords: *Action Potentials ; Adenosine Triphosphate/metabolism ; Animals ; Axons/*physiology ; Calcium/metabolism ; Calcium Signaling ; Cell Differentiation ; Cells, Cultured ; Electric Stimulation ; Ganglia, Spinal/cytology/embryology ; Glutamic Acid/metabolism ; Mice ; Myelin Basic Protein/*biosynthesis/genetics/metabolism ; Myelin Sheath/*physiology ; Neural Stem Cells/cytology/metabolism ; Oligodendroglia/cytology/*metabolism ; Proto-Oncogene Proteins c-fyn/metabolism ; Receptors, Transferrin/metabolism ; Signal Transduction ; Synaptic Transmission ; Synaptic Vesicles/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Neuroscience. Myelin--more than insulation (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fields, R Douglas -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 Apr 18;344(6181):264-6. doi: 10.1126/science.1253851.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Building 35, Room 2A211, MSC 3713, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24744365" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Myelin Sheath/*physiology ; Neocortex/*cytology ; Pyramidal Cells/*physiology ; Somatosensory Cortex/*cytology ; Visual Cortex/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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