Publication Date:
2010-03-13
Description:
Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicular epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snippert, Hugo J -- Haegebarth, Andrea -- Kasper, Maria -- Jaks, Viljar -- van Es, Johan H -- Barker, Nick -- van de Wetering, Marc -- van den Born, Maaike -- Begthel, Harry -- Vries, Robert G -- Stange, Daniel E -- Toftgard, Rune -- Clevers, Hans -- New York, N.Y. -- Science. 2010 Mar 12;327(5971):1385-9. doi: 10.1126/science.1184733.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20223988" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Cell Lineage
;
Epidermis/cytology
;
Gene Expression Profiling
;
Gene Knock-In Techniques
;
Hair/cytology/embryology/growth & development
;
Hair Follicle/*cytology/embryology/growth & development
;
Mice
;
Mice, Nude
;
Receptors, G-Protein-Coupled/*genetics/*metabolism
;
Sebaceous Glands/cytology
;
Signal Transduction
;
Skin/*cytology
;
Stem Cell Transplantation
;
Stem Cells/*cytology/metabolism
;
Wound Healing
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
