Publication Date:
2006-10-28
Description:
DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Ying -- Jorda, Mireia -- Jones, Peter L -- Maleszka, Ryszard -- Ling, Xu -- Robertson, Hugh M -- Mizzen, Craig A -- Peinado, Miguel A -- Robinson, Gene E -- New York, N.Y. -- Science. 2006 Oct 27;314(5799):645-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17068262" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Composition
;
Bees/enzymology/*genetics/*metabolism
;
Computational Biology
;
DNA/chemistry/metabolism
;
DNA (Cytosine-5-)-Methyltransferase/chemistry/*genetics/*metabolism
;
*DNA Methylation
;
DNA-Binding Proteins/genetics/metabolism
;
Dinucleoside Phosphates/*metabolism
;
Genes, Insect
;
Genome, Insect
;
Insect Proteins/genetics/metabolism
;
Molecular Sequence Data
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
