Publication Date:
2004-10-30
Description:
Polar transport-dependent local accumulation of auxin provides positional cues for multiple plant patterning processes. This directional auxin flow depends on the polar subcellular localization of the PIN auxin efflux regulators. Overexpression of the PINOID protein kinase induces a basal-to-apical shift in PIN localization, resulting in the loss of auxin gradients and strong defects in embryo and seedling roots. Conversely, pid loss of function induces an apical-to-basal shift in PIN1 polar targeting at the inflorescence apex, accompanied by defective organogenesis. Our results show that a PINOID-dependent binary switch controls PIN polarity and mediates changes in auxin flow to create local gradients for patterning processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friml, Jiri -- Yang, Xiong -- Michniewicz, Marta -- Weijers, Dolf -- Quint, Ab -- Tietz, Olaf -- Benjamins, Rene -- Ouwerkerk, Pieter B F -- Ljung, Karin -- Sandberg, Goran -- Hooykaas, Paul J J -- Palme, Klaus -- Offringa, Remko -- New York, N.Y. -- Science. 2004 Oct 29;306(5697):862-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Genetics, Center for Molecular Biology of Plants, University Tubingen, Auf der Morgenstelle 3, D-72076 Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15514156" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/cytology/genetics/growth & development/*metabolism
;
Arabidopsis Proteins/genetics/*metabolism
;
Biological Transport
;
Gene Expression Regulation, Plant
;
Indoleacetic Acids/*metabolism
;
Membrane Transport Proteins/genetics/*metabolism
;
Meristem/metabolism
;
Mutation
;
Plant Epidermis/cytology/metabolism
;
Plant Roots/metabolism
;
Plant Shoots/metabolism
;
Plants, Genetically Modified
;
Protein-Serine-Threonine Kinases/genetics/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
Seeds/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
