Publication Date:
2002-10-05
Description:
We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hill, Catherine A -- Fox, A Nicole -- Pitts, R Jason -- Kent, Lauren B -- Tan, Perciliz L -- Chrystal, Mathew A -- Cravchik, Anibal -- Collins, Frank H -- Robertson, Hugh M -- Zwiebel, Laurence J -- F31 DC05265-01A1/DC/NIDCD NIH HHS/ -- R01 DC004692/DC/NIDCD NIH HHS/ -- R01 DC04692-01/DC/NIDCD NIH HHS/ -- U01AI48846/AI/NIAID NIH HHS/ -- U01AI50687/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):176-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364795" target="_blank"〉PubMed〈/a〉
Keywords:
Alternative Splicing
;
Amino Acid Sequence
;
Animals
;
Anopheles/chemistry/*genetics/metabolism
;
Computational Biology
;
Conserved Sequence
;
Drosophila Proteins/chemistry/genetics/metabolism
;
Drosophila melanogaster/chemistry/genetics/metabolism
;
Evolution, Molecular
;
GTP-Binding Proteins/*metabolism
;
Gene Amplification
;
Gene Expression
;
*Genes, Insect
;
Genome
;
Insect Proteins/chemistry/*genetics/metabolism
;
Molecular Sequence Data
;
Multigene Family
;
Phylogeny
;
Receptors, Cell Surface/chemistry/*genetics/metabolism
;
Receptors, Odorant/chemistry/*genetics/metabolism
;
Reverse Transcriptase Polymerase Chain Reaction
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
