Publication Date:
2002-09-28
Description:
Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arbeitman, Michelle N -- Furlong, Eileen E M -- Imam, Farhad -- Johnson, Eric -- Null, Brian H -- Baker, Bruce S -- Krasnow, Mark A -- Scott, Matthew P -- Davis, Ronald W -- White, Kevin P -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2002 Sep 27;297(5590):2270-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12351791" target="_blank"〉PubMed〈/a〉
Keywords:
Algorithms
;
Animals
;
Cluster Analysis
;
Drosophila Proteins/genetics/physiology
;
Drosophila melanogaster/embryology/*genetics/*growth & development
;
Embryo, Nonmammalian/physiology
;
Female
;
*Gene Expression
;
Gene Expression Profiling
;
Gene Expression Regulation, Developmental
;
*Genes, Insect
;
Germ Cells/physiology
;
Larva/genetics
;
Life Cycle Stages/*genetics
;
Male
;
Oligonucleotide Array Sequence Analysis
;
Organ Specificity
;
Pupa/genetics
;
RNA, Messenger/genetics/metabolism
;
Sex Characteristics
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
