Publication Date:
2008-10-17
Description:
The ability to process temporal information is fundamental to sensory perception, cognitive processing and motor behaviour of all living organisms, from amoebae to humans. Neural circuit mechanisms based on neuronal and synaptic properties have been shown to process temporal information over the range of tens of microseconds to hundreds of milliseconds. How neural circuits process temporal information in the range of seconds to minutes is much less understood. Studies of working memory in monkeys and rats have shown that neurons in the prefrontal cortex, the parietal cortex and the thalamus exhibit ramping activities that linearly correlate with the lapse of time until the end of a specific time interval of several seconds that the animal is trained to memorize. Many organisms can also memorize the time interval of rhythmic sensory stimuli in the timescale of seconds and can coordinate motor behaviour accordingly, for example, by keeping the rhythm after exposure to the beat of music. Here we report a form of rhythmic activity among specific neuronal ensembles in the zebrafish optic tectum, which retains the memory of the time interval (in the order of seconds) of repetitive sensory stimuli for a duration of up to approximately 20 s. After repetitive visual conditioning stimulation (CS) of zebrafish larvae, we observed rhythmic post-CS activities among specific tectal neuronal ensembles, with a regular interval that closely matched the CS. Visuomotor behaviour of the zebrafish larvae also showed regular post-CS repetitions at the entrained time interval that correlated with rhythmic neuronal ensemble activities in the tectum. Thus, rhythmic activities among specific neuronal ensembles may act as an adjustable 'metronome' for time intervals in the order of seconds, and serve as a mechanism for the short-term perceptual memory of rhythmic sensory experience.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896960/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896960/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sumbre, German -- Muto, Akira -- Baier, Herwig -- Poo, Mu-ming -- R01 EY012406/EY/NEI NIH HHS/ -- R01 EY012406-01/EY/NEI NIH HHS/ -- R01 EY012406-02/EY/NEI NIH HHS/ -- R01 EY012406-03/EY/NEI NIH HHS/ -- R01 EY012406-04/EY/NEI NIH HHS/ -- R01 EY012406-05/EY/NEI NIH HHS/ -- R01 EY012406-06A2/EY/NEI NIH HHS/ -- R01 EY012406-07/EY/NEI NIH HHS/ -- R01 EY012406-08/EY/NEI NIH HHS/ -- R01 EY012406-09/EY/NEI NIH HHS/ -- R01 NS053358/NS/NINDS NIH HHS/ -- R01 NS053358-01A2/NS/NINDS NIH HHS/ -- R01 NS053358-02/NS/NINDS NIH HHS/ -- R01 NS053358-02S1/NS/NINDS NIH HHS/ -- R01 NS053358-03/NS/NINDS NIH HHS/ -- R01 NS053358-04/NS/NINDS NIH HHS/ -- England -- Nature. 2008 Nov 6;456(7218):102-6. doi: 10.1038/nature07351. Epub 2008 Oct 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18923391" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium/metabolism
;
Conditioning (Psychology)
;
Larva/physiology
;
Memory/*physiology
;
Neurons/*physiology
;
*Periodicity
;
Photic Stimulation
;
Superior Colliculi/cytology/physiology
;
Swimming/physiology
;
Tail/physiology
;
Time Factors
;
Zebrafish/embryology/growth & development/*physiology
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
