Publication Date:
2008-04-18
Description:
We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but how neural circuits make decisions remains poorly understood. Here we simultaneously record from the dorsal premotor area (PMd) in frontal cortex and the parietal reach region (PRR) in parietal cortex to investigate neural circuit mechanisms for decision making. We find that correlations in spike and local field potential (LFP) activity between these areas are greater when monkeys are freely making choices than when they are following instructions. We propose that a decision circuit featuring a sub-population of cells in frontal and parietal cortex may exchange information to coordinate activity between these areas. Cells participating in this decision circuit may influence movement choices by providing a common bias to the selection of movement goals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728060/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728060/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pesaran, Bijan -- Nelson, Matthew J -- Andersen, Richard A -- R01 EY007492/EY/NEI NIH HHS/ -- R01 EY007492-19/EY/NEI NIH HHS/ -- England -- Nature. 2008 May 15;453(7193):406-9. doi: 10.1038/nature06849. Epub 2008 Apr 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Neural Science, New York University, New York, New York 10003, USA. bijan@nyu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18418380" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials/physiology
;
Animals
;
Choice Behavior/*physiology
;
Fixation, Ocular/physiology
;
Frontal Lobe/*physiology
;
Macaca mulatta/*physiology
;
Male
;
Neural Pathways/*physiology
;
Neurons/metabolism
;
Parietal Lobe/*physiology
;
Photic Stimulation
;
Probability
;
ROC Curve
;
Reward
;
Saccades/physiology
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
