Publication Date:
2019-11-26
Description:
A combination of spaceflight-relevant factors (fluid-shift and radiation) created a different gene expression profile than either factor individually. Some gene pathways including reduced transcriptional machinery, increased neurogenesis and neuropeptide production, and dysregulated cell structure and cell signaling. Gene expression differences can persist for at least 4 months after a 21- day exposure to a combination of fluid-shift and radiation in the brain tissue of mice. Brain-related transcriptional changes are dynamic during readaptation phase from exposure to spaceflight-like conditions, which may lead to long-term neurological consequences.
Keywords:
Life Sciences (General)
Type:
ARC-E-DAA-TN75608
,
Annual Meeting of the American Society for Gravitational and Space Research; Nov 20, 2019 - Nov 23, 2019; Denver, CO; United States
Format:
application/pdf