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Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological SequelaeA combination of spaceflight-relevant factors (fluid-shift and radiation) created a different gene expression profile than either factor individually. Some gene pathways including reduced transcriptional machinery, increased neurogenesis and neuropeptide production, and dysregulated cell structure and cell signaling. Gene expression differences can persist for at least 4 months after a 21- day exposure to a combination of fluid-shift and radiation in the brain tissue of mice. Brain-related transcriptional changes are dynamic during readaptation phase from exposure to spaceflight-like conditions, which may lead to long-term neurological consequences.



Document ID
20190033171
Acquisition Source
Ames Research Center
Document Type
Presentation
Authors
Overbey, Eliah G. (Washington Univ. Seattle, WA, United States)
Paul, Amber M. (NASA Ames Research Center Moffett Field, CA, United States)
Silveira, Willian A. da (Queen's University Belfast, Northern Ireland, United Kingdom)
Tahimic, Candice G.T. (NASA Ames Research Center Moffett Field, CA, United States)
Reinsch, Sigrid S. (NASA Ames Research Center Moffett Field, CA, United States)
Szewczyk, Nathaniel (University of Nottingham Derbyshire, England, United Kingdom)
Stanbouly, Seta (Loma Linda Univ. CA, United States)
Wang, Charles (Loma Linda Univ. Medical Center Loma Linda, CA, United States)
Galazka, Jonathan M. (NASA Ames Research Center Moffett Field, CA, United States)
Mao, Xiao Wen (Loma Linda Univ. CA, United States)
Date Acquired
November 22, 2019
Publication Date
November 20, 2019
Subject Category
Life Sciences (General)
Report/Patent Number
ARC-E-DAA-TN75608
Meeting Information
Meeting: Annual Meeting of the American Society for Gravitational and Space Research
Location: Denver, CO
Country: United States
Start Date: November 20, 2019
End Date: November 23, 2019
Sponsors: American Society for Gravitational and Space Research (ASGSR)
Funding Number(s)
CONTRACT_GRANT: NNH15CO48B
Distribution Limits
Public
Copyright
Public Use Permitted.

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