ISSN:
1432-1254
Keywords:
Polyol pathway
;
Diabetes mellitus
;
Water immersion
;
Heat stress
Source:
Springer Online Journal Archives 1860-2000
Topics:
Geography
,
Physics
Notes:
Abstract Activities of erythrocyte aldose reductase were compared in 34 normal subjects, 45 diabetic patients, and nine young men following immersion in water at 25, 39, and 42° C. Mean basal enzyme activity was 1.11 (SEM 0.12) U/g Hb and 2.07 (SEM 0.14) U/g Hb in normal controls and diabetic patients, respectively (P〈0.0001). Activities of the enzyme showed a good correlation with hemaglobin A1 (HbA1) concentrations (P〈0.01) but not with fasting plasma glucose concentrations. After immersion at 42° C for 10 min, enzyme activity was increased by 37.6% (P〈0.01); however, the activity decreased by 52.2% (P〈0.005) after immersion for 10 min at 39° C and by 47.0% (P〈0.05) at 25° C. These changes suggest that heat stress might aggravate diabetic complications, and body exposure to hot environmental conditions is not recommended for diabetic patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01270659
