ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Seven congenic strains differing from C57BL/10Sn at theH-13 locus have been produced which define fourH-13 alleles. Isografting, exchanging of grafts between sublines, F1 testing, and linkage testing demonstrate the presence of additionalH genes in four of these strains. The medial survival times (MSTs) of skin grafts fromH-13a to unimmunizedH-13b recipients ranged from 69 to 83 days. Rejection across all other barriers was extremely weak with most MSTs being 〉 100 days. Preinjection of donor strain thymocytes caused accelerated rejection of skin grafts fromH-13a toH-13b mice, but had only minimal effect on skin grafts across other barriers. Rejection ofH-13 incompatible grafts was significantly stronger when the donor and host areH-3a than when they wereH-3b.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01844032
