ISSN:
1432-1041
Keywords:
(±)-Nicardipine, Nifedipine, Hypertension
;
elderly, pharmacokinetics, pharmacodynamics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The concentration-effect relationships of (±)-nicardipine and nifedipine have been investigated in hypertensive geriatric patients. Following a parallel group, randomised, double blind trial design, they received either slow release nifedipine 20 mg b. d. (n = 9) or slow release (±)-nicardipine 50 mg b. d. (n=10) for 7 days. On Days 1 and 7 serum (±)-nicardipine and nifedipine, blood pressure and heart rate were measured 6 and 12 h after drug administration. (±)-Nicardipine showed significant cumulation (ca 2x) without a corresponding decrease in blood pressure or increase in heart rate. Concentration-effect plots indicated that (±)-nicardipine was more potent than nifedipine but that it showed apparently comparable efficacy in reducing the blood pressure. Compared to young healthy volunteers, both drugs had a more pronounced effect in elderly patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02285101
