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Serum concentration-effect relationship of (±)-nicardipine and nifedipine in elderly hypertensive patients

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Summary

The concentration-effect relationships of (±)-nicardipine and nifedipine have been investigated in hypertensive geriatric patients. Following a parallel group, randomised, double blind trial design, they received either slow release nifedipine 20 mg b. d. (n = 9) or slow release (±)-nicardipine 50 mg b. d. (n=10) for 7 days. On Days 1 and 7 serum (±)-nicardipine and nifedipine, blood pressure and heart rate were measured 6 and 12 h after drug administration.

(±)-Nicardipine showed significant cumulation (ca 2x) without a corresponding decrease in blood pressure or increase in heart rate. Concentration-effect plots indicated that (±)-nicardipine was more potent than nifedipine but that it showed apparently comparable efficacy in reducing the blood pressure.

Compared to young healthy volunteers, both drugs had a more pronounced effect in elderly patients.

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Authors and Affiliations

  1. Division of Clinical Pharmacology, University Hospital, CH-1211, Geneva 14, Switzerland

    H. C. Porchet &  P. Dayer

  2. University Geriatric Institutions, Geneva, Switzerland

    E. Loew & L. Gauthey

Authors
  1. H. C. Porchet
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  2. E. Loew
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  3. L. Gauthey
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  4. P. Dayer
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Porchet, H.C., Loew, E., Gauthey, L. et al. Serum concentration-effect relationship of (±)-nicardipine and nifedipine in elderly hypertensive patients. Eur J Clin Pharmacol 43, 551–553 (1992). https://doi.org/10.1007/BF02285101

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  • DOI: https://doi.org/10.1007/BF02285101

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