ISSN:
1618-2650
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The analytical strategy for the elemental chemical characterization of biological reference materials followed during a recently completed Reference Material development endeavour is discussed. Characterization, the assignment of reliable values to total elemental concentrations of a wide range of elements, poses the most difficult challenge in the scheme of reference material (RM) production. A review is presented of the many factors considered that significantly impinged on the conduct and outcome of the complex analytical characterization exercise. Major considerations were: (1) analytical elemental characterization philosophy, (2) analyte selection, (3) selection of analytical methodologies, (4) statistical protocols, (5) in-house characterization, (6) assessment of material homogeneity (7) cooperative interlaboratory characterization campaign, (8) data evaluation and (9) calculation of concentration values and associated uncertainties.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00322295