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Analytical strategy for the chemical characterization of biological reference materials

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Abstract

The analytical strategy for the elemental chemical characterization of biological reference materials followed during a recently completed Reference Material development endeavour is discussed. Characterization, the assignment of reliable values to total elemental concentrations of a wide range of elements, poses the most difficult challenge in the scheme of reference material (RM) production. A review is presented of the many factors considered that significantly impinged on the conduct and outcome of the complex analytical characterization exercise. Major considerations were: (1) analytical elemental characterization philosophy, (2) analyte selection, (3) selection of analytical methodologies, (4) statistical protocols, (5) in-house characterization, (6) assessment of material homogeneity (7) cooperative interlaboratory characterization campaign, (8) data evaluation and (9) calculation of concentration values and associated uncertainties.

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Authors and Affiliations

  1. Centre for Land and Biological Resources Research, Research Branch, Agriculture and Agri-Food Canada, K1A OC6, Ottawa, Ontario, Canada

    Milan Ihnat

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  1. Milan Ihnat
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Contribution no. 94-47 from Centre for Land and Biological Resources Research

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Ihnat, M. Analytical strategy for the chemical characterization of biological reference materials. Fresenius J Anal Chem 352, 49–52 (1995). https://doi.org/10.1007/BF00322295

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  • DOI: https://doi.org/10.1007/BF00322295

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