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Anticonvulsant and Monoamine Oxidase Inhibitory Activities of some Triazene N1-Oxides (1985)

Kumar, Ashok ; Mukerjee, S. K. ; Bhattacharya, S. K.

Springer

Pharmaceutical research 2 (1985), S. 49-52

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ISSN: 1573-904X

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract Thirty-three N 3-2-, -3- or -4-substituted aryl-N 1-(alkyl/aryl/substituted aryl)-triazene N 1-oxides were synthesized and evaluated for their anticonvulsant and monoamine oxidase (MAO) inhibitory activities. Most of the compounds exhibited MAO inhibitory activity in vitro, and kinetic studies conducted with N 3-4-chlorophenyl-N 1-methyltriazene N 1-oxide, the most potent inhibitor, showed that the inhibition is non-competitive in nature. The MAO inhibiting activity of the compounds correlated well with their anticonvulsant effect against maximal electroshock-induced seizures in rats. Acute toxicity studies indicate that the compounds have a wide margin of safety.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1016374224529

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