ISSN:
1573-6830
Keywords:
neuropeptide
;
chromogranins
;
secretogranin
;
VGF
;
prohormone con-vertases
;
cytochrome b-561
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract 1. The proteins of large dense-core vesicles (LDV) in neuroendocrine tissues are well characterized. Secretory components comprise chromogranins and neuropeptides. Intrinsicmembrane proteins include cytochrome b-561, transporters, SV2, synaptotagmin, and sy-naptobrevin. 2. The effects of stimulation and of second messengers on the biosynthesis of LDV have been studied in detail. 3. Regulation of biosynthesis is complex. The cell can adapt to prolonged stimulation either by producing vesicles of normal size filled with a higher quantum of secretorypeptides or by forming larger vesicles. In addition, some components, e.g., enzymes, canbe upregulated specifically.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1022516919932
