ISSN:
1420-9071
Keywords:
Transplantation
;
goat
;
fetal liver
;
β-D-mannosidosis
;
hemopoietic chimerism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Intraperitoneal injection of allogeneic liver cells from 43-day-old male fetuses into normal 60-day female goat fetuses resulted in persistent hemopoietic chimerism in surviving recipients without clinical evidence of graft-versus-host disease. Transplantation of normal fetal liver cells into preimmunocompetent goat fetuses affected with β-D-mannosidosis may provide an alternative strategy for evaluating hemopoietic stem cell transplantation in the treatment of human lysosomal storage diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01951819