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Induction of hemopoietic chimerism in the caprine fetus by intraperitoneal injection of fetal liver cells

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Summary

Intraperitoneal injection of allogeneic liver cells from 43-day-old male fetuses into normal 60-day female goat fetuses resulted in persistent hemopoietic chimerism in surviving recipients without clinical evidence of graft-versus-host disease. Transplantation of normal fetal liver cells into preimmunocompetent goat fetuses affected with β-D-mannosidosis may provide an alternative strategy for evaluating hemopoietic stem cell transplantation in the treatment of human lysosomal storage diseases.

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Authors and Affiliations

  1. Department of Pediatrics and University of Toronto, The Hospital for Sick Children, M5G 1X8, Toronto, Ontario, Canada

    R. D. Pearce, J. W. Callahan & J. T. R. Clarke

  2. MRC Group in Reproductive Biology, University Hospital, N6A 5A5, London, Ontario, Canada

    D. Kiehm & D. T. Armstrong

  3. Department of Pathology, Ontario Veterinary College, University of Guelph, N1G 2W1, Guelph, Ontario, Canada

    P. B. Little

  4. Cytogenetics Laboratory, George D. Widener Hospital for Large Animals, New Bolton Center, University of Pennsylvania, 19348, Kennett Square, Pennsylvania, USA

    L. R. Klunder

Authors
  1. R. D. Pearce
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  2. D. Kiehm
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  3. D. T. Armstrong
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  4. P. B. Little
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  5. J. W. Callahan
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  6. L. R. Klunder
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  7. J. T. R. Clarke
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Pearce, R.D., Kiehm, D., Armstrong, D.T. et al. Induction of hemopoietic chimerism in the caprine fetus by intraperitoneal injection of fetal liver cells. Experientia 45, 307–308 (1989). https://doi.org/10.1007/BF01951819

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  • DOI: https://doi.org/10.1007/BF01951819

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