Publication Date:
1999-07-31
Description:
Many immune receptors are composed of separate ligand-binding and signal-transducing subunits. In natural killer (NK) and T cells, DAP10 was identified as a cell surface adaptor protein in an activating receptor complex with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompatibility complex molecule MICA. Within the DAP10 cytoplasmic domain, an Src homology 2 (SH2) domain-binding site was capable of recruiting the p85 subunit of the phosphatidylinositol 3-kinase (PI 3-kinase), providing for NKG2D-dependent signal transduction. Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wu, J -- Song, Y -- Bakker, A B -- Bauer, S -- Spies, T -- Lanier, L L -- Phillips, J H -- AI30581/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):730-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10426994" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Binding Sites
;
Cell Line
;
Cytotoxicity, Immunologic
;
Humans
;
Killer Cells, Natural/*immunology/metabolism
;
Ligands
;
*Lymphocyte Activation
;
Membrane Proteins/chemistry/genetics/*metabolism
;
Mice
;
Molecular Sequence Data
;
NK Cell Lectin-Like Receptor Subfamily K
;
Neoplasms/immunology
;
Phosphatidylinositol 3-Kinases/metabolism
;
Phosphorylation
;
Phosphotyrosine/metabolism
;
Receptors, Immunologic/chemistry/genetics/*metabolism
;
Receptors, Natural Killer Cell
;
Signal Transduction
;
T-Lymphocytes/*immunology/metabolism
;
Tumor Cells, Cultured
;
src Homology Domains
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
