Publikationsdatum:
2004-05-01
Beschreibung:
Receptor tyrosine kinase genes were sequenced in non-small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGFR were found in 15of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment with the EGFR kinase inhibitor gefitinib (Iressa) causes tumor regression in some patients with NSCLC, more frequently in Japan. EGFR mutations were found in additional lung cancer samples from U.S. patients who responded to gefitinib therapy and in a lung adenocarcinoma cell line that was hypersensitive to growth inhibition by gefitinib, but not in gefitinib-insensitive tumors or cell lines. These results suggest that EGFR mutations may predict sensitivity to gefitinib.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paez, J Guillermo -- Janne, Pasi A -- Lee, Jeffrey C -- Tracy, Sean -- Greulich, Heidi -- Gabriel, Stacey -- Herman, Paula -- Kaye, Frederic J -- Lindeman, Neal -- Boggon, Titus J -- Naoki, Katsuhiko -- Sasaki, Hidefumi -- Fujii, Yoshitaka -- Eck, Michael J -- Sellers, William R -- Johnson, Bruce E -- Meyerson, Matthew -- New York, N.Y. -- Science. 2004 Jun 4;304(5676):1497-500. Epub 2004 Apr 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Medical Oncology and Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15118125" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Adenocarcinoma/drug therapy/genetics/metabolism
;
Amino Acid Motifs
;
Amino Acid Sequence
;
Amino Acid Substitution
;
Antineoplastic Agents/pharmacology/therapeutic use
;
Carcinoma, Non-Small-Cell Lung/drug therapy/*genetics/metabolism
;
Cell Line, Tumor
;
Controlled Clinical Trials as Topic
;
Enzyme Inhibitors/pharmacology/therapeutic use
;
Female
;
*Genes, erbB-1
;
Humans
;
Japan
;
Lung Neoplasms/drug therapy/*genetics/metabolism
;
Male
;
Molecular Sequence Data
;
*Mutation
;
Mutation, Missense
;
Phosphorylation
;
Protein Conformation
;
Protein Structure, Tertiary
;
Quinazolines/pharmacology/*therapeutic use
;
Receptor, Epidermal Growth Factor/*antagonists &
;
inhibitors/chemistry/genetics/metabolism
;
Sequence Deletion
;
Treatment Outcome
;
United States
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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