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  • Articles  (154,125)
  • 1980-1984  (154,125)
  • Medicine  (154,125)
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  • Articles  (154,125)
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  • 1
    Electronic Resource
    Electronic Resource
    A NEW FAST VARIANT (BF*F08) OF THE BF POLYMORPHISM (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: A new variant in the BF polymorphism was found in one individual from an isolate (Dogons) of Mali. It might correspond to the expression of a new allele BF*F08 with haemolytic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb00996.x
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  • 2
    Electronic Resource
    Electronic Resource
    SEROLOGICAL EVIDENCE FOR A PARTIAL t-HAPLOTYPE IN THE RAT (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Recently, Gill and Kunz (1979, 1980) reported an MHC-linked recessive mutation in the rat, grc, which causes reduced viability and male sterility. Using a mouse anti-tsemilethal antiserum and a rat anti-grc antiserum, we have obtained evidence that the grc haplotype codes for t-antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb00997.x
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  • 3
    Electronic Resource
    Electronic Resource
    BRIC 18: A MONOCLONAL ANTIBODY WITH A SPECIFICITY RELATED TO THE KELL BLOOD GROUP SYSTEM (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: A mouse monoclonal antibody (NBTS/BRIC 18) has been produced which has a specificity related to the Kell blood group system. BRIC 18 does not react with human erythrocytes of the Ko phenotype and reacts only very weakly with those of the McLeod phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb00998.x
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  • 4
    Electronic Resource
    Electronic Resource
    HLA, AND THE RESPONSE TO TREATMENT WITH γ-TYPE ENDORPHINS IN SCHIZOPHRENIA (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In order to investigate whether genetic factors are involved in the response of schizophrenic patients to treatment with γ-type endorphins, we typed 32 Dutch schizophrenic patients for the HLA-A, -B, -C and -DR antigens. The total patient group showed an increase of HLA-Bw4 and HLA-Cw1. A subgroup of 20 paranoid patients showed an increase of HLA-Cw1 and a significant heterogeneity for the HLA-C locus. In 16 patients who responded moderately or markedly to treatment with γ-type endorphins, an increase of HLA-B15/Cw3 and a decrease of HLA-B17 were found as compared to 16 patients with no or a slight response. Moreover, HLA-B15 was particularly increased in those patients who responded markedly and remained free of psychotic symptoms for a period of at least 6 months after treatment with γ-type endorphins (RR = 24.6, Puncorr.= 0.0015).Our results suggest that genetic factors coded for within the HLA region are associated with paranoid schizophrenia, and that HLA-B15/Cw3 is associated with a marked and prolonged response to treatment with γ-type endorphins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb00999.x
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  • 5
    Electronic Resource
    Electronic Resource
    PRECISE MAPPING OF THE GENE FOR Ly -21. 2 ON THE 7th CHROMOSOME (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: We have recently described a murine lymphocyte alloantigen, Ly-21.2, and showed that the gene which controls Ly-21.2 expression is linked to albinism on the 7th chromosome. In order to map the gene more precisely, we have studied the linkage of Ly-21.2 with two other genetic markers on the 7th chromosome, the electrophoretic variant of the β chain of haemoglobin and glucose phosphate isomerase, in (A/J × C57BL/10)F2 mice. The results of these 3-point cross studies show that the gene encoding Ly-21.2 maps 27 units distal to albinism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb01000.x
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  • 6
    Electronic Resource
    Electronic Resource
    FURTHER ANALYSIS OF THE Ly-6 GENETIC REGION : ISOLATION AND CHARACTERIZATION OF CELL LINES WITH ALTERED EXPRESSION OF Ly-6 ANTIGENS (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The identity, or close linkage, or a series of murine alloantigens encoded by the Ly-6 genetic region has been well documented. We have investigated the relationship between two component antigens, Ly-6.2 and H9/25, by generating and characterizing a number of variant cell lines which have altered antigen expression, isolated by chemical mutagenesis and immunoselection of BW5147 lymphoid cells. Cloned cell lines, selected by either antiserum, show loss of both antigens and also fail to express Thy-1, a further genetically linked, but unrelated determinant. The relevance of these findings to furthering understanding of the structure of the Ly-6 region and regulation of antigen expression is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb01001.x
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  • 7
    Electronic Resource
    Electronic Resource
    IMMUNOLOGICAL CROSS-REACTIVITY BETWEEN H-2DK PRODUCT AND DTIC - TREATED H - 2d LYMPHOMA (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The experiments reported here concern the charcterization by techniques of in vitro cell-mediated immunity of the antigens induced by 5-(3,3'dimethyl-1-triazine)-imidazole-4-carboxamide (DTIC) on L1210, a chemically-induced lymphoma of DBA/2 mice (H-2d). This series of experiments with the DTIC-treated L1210 tumour show the presence of an H-2D'-like antigen which resembles the Dk gene product/s of the H-2k haplotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb01002.x
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  • 8
    Electronic Resource
    Electronic Resource
    NATURAL AGGLUTININS TO HIDDEN MEMBRANE COMPONENTS IN THE BOVINE ERYTHROCYTES (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Digestion of bovine erythrocytes (BE) with trypsin (Tr) or chymotrypsin (CTr) revealed Tr and CTr specific' receptor respectively. These receptor reacted with all the isologous, including the autologous, sera. The titres of agglutinability varied for the Tr-digested BE from 1:2 to 1:64 and from zero to 1:128 for the CTr-digested BE. However, the variation between the members of nomozygous twin pairs (MZ) in no case exceeded ±2 score units, the error limits. Agglutination of the CTr-digested BE gave with the PHA lection very similar, (r= 0.964) results to that which was ontained with the isologous sera.The titre of agglutinins showed concordance in all the sera of MZ pairs when tested against the neuraminidas-digested human erythrocytes and the Tr or CTr-digested BE. Their variance due to differences varied between MZ pairs from 60.4 to 74.3%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb01003.x
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  • 9
    Electronic Resource
    Electronic Resource
    LY - AND ECOTROPIC MuLV ANTIGENS ARE SEPARTE ENTITIES (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Murine alloantisera to lymphocyte (Ly) alloantigens also contain antibodies to murine leukaemia viruses (MuLV) in high titre. A number of such sera were extensively absorbed with ecotropic AKR murine leukaemia virus to remove contaqiminating anti-MuLV antibodies. The virus-absorbed and unabsorbed antisera wre then examined by the radioimmune precipitation (RIP) assay for anti-MuLV antibodies, and for anti-Ly antibodies by cytotoxicity assays against specific target cells. The results presented here demonstrate that whilst virus absorption markdely reduced the anti-viraql titres of the alloantisera they ahd no effect on the anti-Ly titres of any of them. This indicated that none of the Ly antigens which was examined cross reacts with the antigens of ecotropic AKR-MuLV and further suggest that Ly antigens are not encoded by the genes of endogenous ecotropic MuLVs. It was also demonstrated that the majority of the constaninating anti-MuLV antibodies present in anti-Ly-6.2 proteins of the virus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb01004.x
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  • 10
    Electronic Resource
    Electronic Resource
    GENETIC CONTROL OF CELL-MEDIATED IMMUNITY IN THE RAT:II. SHARING OF EITHER THE RTI. A OR RTI. B LOCUS IS SUFFICIENT FOR TRANSFER OF ANTIMICROBIAL RESISTANCE (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The MHC restriction criteria for T cells activating macrophages in vivo and mediating antimicrobiol resistance to Listeria monocytogenes were determined. Antimicribiol resistance could be transferred by T cell in order of decreasing efficiency from syngeneic. RT1A. compatible, RTI.B compatible and RT1 incompatible donors. Alloreactive T cells responding to either A locus or B locus encoded antigens in a graft-versus-host reaction were also able to activate macrophages. Approximately five times as many MLC-reactive precursors responded to B locus alloantigens as to A locus alloantigens, but A-resticted Listeria-specific T cells wre considerably more numerous (or more efficient) in Listeriainfected hosts than were B-restricted, Listeria-specific T cells. This was unexpected, since A-restricted, Listeria-specific T cells failed to transfer delayed hypersensitivity (DTH) to soluble bacterial antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb01005.x
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