ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
The MHC restriction criteria for T cells activating macrophages in vivo and mediating antimicrobiol resistance to Listeria monocytogenes were determined. Antimicribiol resistance could be transferred by T cell in order of decreasing efficiency from syngeneic. RT1A. compatible, RTI.B compatible and RT1 incompatible donors. Alloreactive T cells responding to either A locus or B locus encoded antigens in a graft-versus-host reaction were also able to activate macrophages. Approximately five times as many MLC-reactive precursors responded to B locus alloantigens as to A locus alloantigens, but A-resticted Listeria-specific T cells wre considerably more numerous (or more efficient) in Listeriainfected hosts than were B-restricted, Listeria-specific T cells. This was unexpected, since A-restricted, Listeria-specific T cells failed to transfer delayed hypersensitivity (DTH) to soluble bacterial antigens.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1982.tb01005.x
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