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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):29. doi: 10.1126/science.344.6179.29.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700839" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Administrative Personnel ; Biomedical Research/*economics/organization & administration ; Budgets ; Financing, Government ; Illinois ; National Institutes of Health (U.S.)/economics ; Research Support as Topic/*organization & administration ; United States ; Universities/*economics/organization & administration
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 2
    Publikationsdatum: 2014-05-31
    Beschreibung: Synaptic vesicle recycling has long served as a model for the general mechanisms of cellular trafficking. We used an integrative approach, combining quantitative immunoblotting and mass spectrometry to determine protein numbers; electron microscopy to measure organelle numbers, sizes, and positions; and super-resolution fluorescence microscopy to localize the proteins. Using these data, we generated a three-dimensional model of an "average" synapse, displaying 300,000 proteins in atomic detail. The copy numbers of proteins involved in the same step of synaptic vesicle recycling correlated closely. In contrast, copy numbers varied over more than three orders of magnitude between steps, from about 150 copies for the endosomal fusion proteins to more than 20,000 for the exocytotic ones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilhelm, Benjamin G -- Mandad, Sunit -- Truckenbrodt, Sven -- Krohnert, Katharina -- Schafer, Christina -- Rammner, Burkhard -- Koo, Seong Joo -- Classen, Gala A -- Krauss, Michael -- Haucke, Volker -- Urlaub, Henning -- Rizzoli, Silvio O -- New York, N.Y. -- Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuro- and Sensory Physiology, University of Gottingen Medical Center, European Neuroscience Institute, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Gottingen, Germany. International Max Planck Research School Neurosciences, 37077 Gottingen, Germany. ; Bioanalytical Mass Spectrometry Group, Max-Planck-Institute for Biophysical Chemistry, 37077 Gottingen, Germany. ; Department of Neuro- and Sensory Physiology, University of Gottingen Medical Center, European Neuroscience Institute, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Gottingen, Germany. International Max Planck Research School Molecular Biology, 37077 Gottingen, Germany. ; Department of Neuro- and Sensory Physiology, University of Gottingen Medical Center, European Neuroscience Institute, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Gottingen, Germany. ; Leibniz Institut fur Molekulare Pharmakologie, Department of Molecular Pharmacology and Cell Biology, Robert-Rossle-Strasse 10, 13125 Berlin, Germany. ; Bioanalytical Mass Spectrometry Group, Max-Planck-Institute for Biophysical Chemistry, 37077 Gottingen, Germany. Bioanalytics, Department of Clinical Chemistry, University Medical Center Gottingen, 37075 Gottingen, Germany. ; Department of Neuro- and Sensory Physiology, University of Gottingen Medical Center, European Neuroscience Institute, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Gottingen, Germany. srizzol@gwdg.de.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876496" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/*metabolism/ultrastructure ; Exocytosis ; Imaging, Three-Dimensional ; Immunoblotting/methods ; Mass Spectrometry/methods ; Microscopy, Electron/methods ; Models, Neurological ; Presynaptic Terminals/chemistry/*metabolism/ultrastructure ; Protein Transport ; Rats ; Rats, Wistar ; Synaptic Vesicles/chemistry/*metabolism ; Synaptosomes/chemistry/*metabolism/ultrastructure ; Vesicular Transport Proteins/analysis/*metabolism
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 3
    Publikationsdatum: 2014-03-29
    Beschreibung: The field of optogenetics uses channelrhodopsins (ChRs) for light-induced neuronal activation. However, optimized tools for cellular inhibition at moderate light levels are lacking. We found that replacement of E90 in the central gate of ChR with positively charged residues produces chloride-conducting ChRs (ChloCs) with only negligible cation conductance. Molecular dynamics modeling unveiled that a high-affinity Cl(-)-binding site had been generated near the gate. Stabilizing the open state dramatically increased the operational light sensitivity of expressing cells (slow ChloC). In CA1 pyramidal cells, ChloCs completely inhibited action potentials triggered by depolarizing current injections or synaptic stimulation. Thus, by inverting the charge of the selectivity filter, we have created a class of directly light-gated anion channels that can be used to block neuronal output in a fully reversible fashion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wietek, Jonas -- Wiegert, J Simon -- Adeishvili, Nona -- Schneider, Franziska -- Watanabe, Hiroshi -- Tsunoda, Satoshi P -- Vogt, Arend -- Elstner, Marcus -- Oertner, Thomas G -- Hegemann, Peter -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):409-12. doi: 10.1126/science.1249375. Epub 2014 Mar 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Biology, Experimental Biophysics, Humboldt Universitat zu Berlin, D-10115 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24674867" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials ; Animals ; Binding Sites ; CA1 Region, Hippocampal/cytology ; Chloride Channels/*chemistry/*metabolism ; Chlorides/*metabolism ; HEK293 Cells ; Humans ; Hydrogen Bonding ; Ion Channel Gating ; Light ; Models, Molecular ; Molecular Dynamics Simulation ; Mutation ; Patch-Clamp Techniques ; Protein Conformation ; Protein Engineering ; Pyramidal Cells/metabolism ; Rats ; Recombinant Fusion Proteins/chemistry ; Rhodopsin/*chemistry/genetics/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Mar 28;343(6178):1460-1. doi: 10.1126/science.343.6178.1460.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24675951" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*economics ; *Breast Neoplasms ; Female ; Humans ; *Patient Advocacy ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):26. doi: 10.1126/science.344.6179.26.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700836" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*economics ; Financing, Government ; Humans ; National Institutes of Health (U.S.)/*economics ; Parkinson Disease ; Research Personnel/*economics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arita, Isao -- Francis, Donald -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1010. doi: 10.1126/science.345.6200.1010-a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Director Emeritus, National Hospital Organization, Kumamoto Medical Center, Kumamoto 861-8068, Japan. ; Executive Director, Global Solutions for Infectious Diseases, South San Francisco, CA 94080, USA. dfrancis@gsid.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170141" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Biological Specimen Banks ; Biological Warfare Agents ; *Disease Eradication ; Humans ; Risk Assessment ; Russia ; Smallpox/epidemiology/*prevention & control/virology ; United States ; *Variola virus ; World Health Organization
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):238. doi: 10.1126/science.343.6168.238.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436398" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agriculture ; Air Pollutants/*adverse effects/analysis ; Air Pollution/*adverse effects/prevention & control ; Ammonia/*adverse effects/analysis ; Animals ; Fertilizers/*adverse effects ; Health/*economics ; Heart Diseases/chemically induced ; Humans ; Livestock ; Models, Biological ; North Carolina ; Particulate Matter/*adverse effects/analysis ; Respiratory Tract Diseases/chemically induced ; United States ; United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2014 May 16;344(6185):679. doi: 10.1126/science.344.6185.679.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24833367" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Experimentation/*standards ; Animals ; Biomedical Research/*standards ; Cells ; Female ; Male ; Mice ; National Institutes of Health (U.S.) ; Sex Factors ; United States ; X Chromosome ; Y Chromosome
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clery, Daniel -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):290-1. doi: 10.1126/science.346.6207.290.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324365" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Chemistry ; Mice ; Microscopy, Fluorescence/*methods ; *Nobel Prize ; Organelles/ultrastructure ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):6. doi: 10.1126/science.1250035.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt is Editor-in-Chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385608" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Budgets ; Gross Domestic Product/trends ; Research/*economics/*trends ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):229. doi: 10.1126/science.1250475.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt is Editor-in-Chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436391" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Disclosure/*standards ; *Guidelines as Topic ; Humans ; National Institute of Neurological Disorders and Stroke ; *Peer Review, Research ; Reproducibility of Results ; Translational Medical Research/standards ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):24-5. doi: 10.1126/science.344.6179.24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700835" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*economics ; Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic/trends ; United States ; Universities/economics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):15. doi: 10.1126/science.343.6166.15.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385614" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Research Report ; Social Control, Formal ; United States ; *United States Environmental Protection Agency ; *Wetlands
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):359. doi: 10.1126/science.343.6169.359.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458618" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Consumer Organizations ; *Embryonic Stem Cells ; Humans ; *Patents as Topic ; Stem Cell Research/*legislation & jurisprudence ; Supreme Court Decisions ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-11-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woolley, Mary -- Leshner, Alan I -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):791. doi: 10.1126/science.aaa2692.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mary Woolley is the president and chief executive officer of Research!America. mwoolley@researchamerica.org. ; Alan I. Leshner is the chief executive officer of the American Association for the Advancement of Science and executive publisher of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395507" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Earthquakes ; *Federal Government ; Floods ; Hemorrhagic Fever, Ebola ; Humans ; Petroleum Pollution ; Politics ; Science/*economics/*trends ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 16
    Publikationsdatum: 2014-04-26
    Beschreibung: Using light to silence electrical activity in targeted cells is a major goal of optogenetics. Available optogenetic proteins that directly move ions to achieve silencing are inefficient, pumping only a single ion per photon across the cell membrane rather than allowing many ions per photon to flow through a channel pore. Building on high-resolution crystal-structure analysis, pore vestibule modeling, and structure-guided protein engineering, we designed and characterized a class of channelrhodopsins (originally cation-conducting) converted into chloride-conducting anion channels. These tools enable fast optical inhibition of action potentials and can be engineered to display step-function kinetics for stable inhibition, outlasting light pulses and for orders-of-magnitude-greater light sensitivity of inhibited cells. The resulting family of proteins defines an approach to more physiological, efficient, and sensitive optogenetic inhibition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096039/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096039/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berndt, Andre -- Lee, Soo Yeun -- Ramakrishnan, Charu -- Deisseroth, Karl -- R01 DA020794/DA/NIDA NIH HHS/ -- R01 MH075957/MH/NIMH NIH HHS/ -- R01 MH086373/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):420-4. doi: 10.1126/science.1252367.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24763591" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials ; Amino Acid Sequence ; Animals ; CA1 Region, Hippocampal/cytology ; CA3 Region, Hippocampal/cytology ; Chloride Channels/*chemistry/*metabolism ; Chlorides/*metabolism ; HEK293 Cells ; Humans ; Light ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Neurons/*physiology ; Optogenetics ; Patch-Clamp Techniques ; Protein Engineering ; Rats ; Rats, Sprague-Dawley ; Recombinant Fusion Proteins/chemistry/metabolism ; Rhodopsin/*chemistry/genetics/*metabolism
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-09-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2014 Sep 19;345(6203):1441-2. doi: 10.1126/science.345.6203.1441.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25237082" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa, Western/epidemiology ; Communicable Disease Control/*economics ; Disease Outbreaks/*prevention & control ; Drug Industry/*economics ; Drugs, Investigational/*economics ; Ebola Vaccines/*economics ; Hemorrhagic Fever, Ebola/*epidemiology/*prevention & control ; Humans ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-04
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2014 Oct 3;346(6205):13. doi: 10.1126/science.346.6205.13. Epub 2014 Oct 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Donald Kennedy is president emeritus at Stanford University, Stanford, CA, and a former editor-in-chief of Science. kennedyd@stanford.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25278586" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agriculture/economics/*trends ; Research/economics/*trends ; United States ; United States Department of Agriculture
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):33. doi: 10.1126/science.344.6179.33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700842" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): BK Virus ; Biomedical Research/*economics ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic/economics/organization & administration ; Salaries and Fringe Benefits ; Travel/economics ; United States ; Virology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1306-9. doi: 10.1126/science.343.6177.1306.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24653017" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biological Evolution ; DNA, Intergenic/genetics ; Databases, Nucleic Acid ; *Genome, Human ; *Genomics ; History, 20th Century ; History, 21st Century ; Humans ; Molecular Sequence Annotation ; Mutation ; National Human Genome Research Institute (U.S.) ; Transcription Factors/metabolism ; Transcription, Genetic ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):239. doi: 10.1126/science.343.6168.239.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436399" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Ants/*microbiology/physiology ; Brain/metabolism/microbiology ; Fat Body/virology ; Female ; Gryllidae/physiology/*virology ; Guanidines/analysis/metabolism ; *Host-Pathogen Interactions ; Hypocreales/*physiology ; Insect Viruses/*physiology ; Lizards/virology ; Male ; Rats ; Sexual Behavior, Animal/*physiology ; Sphingosine/analysis/metabolism ; Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):247-8. doi: 10.1126/science.345.6194.247.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035464" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Anthrax ; Biohazard Release/*prevention & control ; Centers for Disease Control and Prevention (U.S.) ; Humans ; *Influenza, Human ; *Laboratories ; National Institutes of Health (U.S.) ; Public Health ; *Safety ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, Richard A -- New York, N.Y. -- Science. 2014 Apr 11;344(6180):138-9. doi: 10.1126/science.344.6180.138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24723588" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Budgets ; Research Personnel/*economics ; *Solar System ; Space Flight/*economics ; United States ; United States National Aeronautics and Space Administration/*economics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bloom, Barry R -- Marcuse, Edgar -- Mnookin, Seth -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):339. doi: 10.1126/science.1254834.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Barry R. Bloom is a professor at the Harvard School of Public Health, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24763557" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; Disease Outbreaks/*prevention & control ; *Health Knowledge, Attitudes, Practice ; Humans ; Infant ; Parents/*psychology ; *Research ; Research Design ; *Treatment Refusal/psychology ; United States ; *Vaccination/psychology/utilization
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, Francis S -- Wilder, Elizabeth L -- Zerhouni, Elias -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):274-6. doi: 10.1126/science.1255860. Epub 2014 Jun 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Bethesda, MD 20892, USA. francis.collins@nih.gov. ; National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035478" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*economics ; *Financial Management ; Humans ; National Institutes of Health (U.S.)/*economics ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 26
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-09-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hand, Eric -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1233. doi: 10.1126/science.345.6202.1233.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25214586" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air Pollutants/analysis/*standards ; Air Pollution/analysis/*legislation & jurisprudence ; China ; Climate Change ; Ozone/analysis/*standards ; United States ; United States Environmental Protection Agency/economics/legislation & ; jurisprudence ; Wind
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1298. doi: 10.1126/science.343.6177.1298-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24653013" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Budgets ; Financing, Government ; *Politics ; Public Policy ; *Research Support as Topic ; United States ; United States Government Agencies/economics/*legislation & ; jurisprudence/organization & administration
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 28
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 May 23;344(6186):836-7. doi: 10.1126/science.344.6186.836.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855257" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Humans ; Policy Making ; Social Mobility/*statistics & numerical data/*trends ; Taxes ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1298-9. doi: 10.1126/science.343.6177.1298-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24653012" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Budgets ; Financing, Government ; *Politics ; Public Policy ; *Research Support as Topic ; United States ; United States Government Agencies/*legislation & jurisprudence/organization & ; administration
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 30
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Feb 21;343(6173):830. doi: 10.1126/science.343.6173.830.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24558139" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antarctic Regions ; *Federal Government ; Research/*economics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-24
    Beschreibung: This Review presents basic facts regarding the long-run evolution of income and wealth inequality in Europe and the United States. Income and wealth inequality was very high a century ago, particularly in Europe, but dropped dramatically in the first half of the 20th century. Income inequality has surged back in the United States since the 1970s so that the United States is much more unequal than Europe today. We discuss possible interpretations and lessons for the future.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piketty, Thomas -- Saez, Emmanuel -- New York, N.Y. -- Science. 2014 May 23;344(6186):838-43. doi: 10.1126/science.1251936.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics, Paris School of Economics, Paris, France. thomas.piketty@psemail.eu. ; Department of Economics, University of California at Berkeley, Berkeley, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855258" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Economic Development ; Europe ; History, 15th Century ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; History, Ancient ; Humans ; Income/history/*statistics & numerical data/*trends ; Socioeconomic Factors/history ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):357. doi: 10.1126/science.343.6169.357.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458616" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*economics ; *Budgets ; *Financing, Government ; National Institutes of Health (U.S.)/*economics ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 33
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Feb 7;343(6171):596-8. doi: 10.1126/science.343.6171.596.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24503830" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*economics/*trends ; Clinical Trials as Topic/economics/trends ; Financing, Organized ; Humans ; *National Institutes of Health (U.S.) ; *Peer Review, Research ; Publications/*statistics & numerical data ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 34
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):237. doi: 10.1126/science.343.6168.237.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436397" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*economics/education ; *Budgets ; Physics/economics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 35
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Jan 10;343(6167):125-6. doi: 10.1126/science.343.6167.125.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24408407" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Career Choice ; Curriculum ; Science/*education ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cordova, France -- Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 May 30;344(6187):959-61. doi: 10.1126/science.344.6187.959.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876473" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Foundations ; Science/*economics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 37
    Publikationsdatum: 2014-05-24
    Beschreibung: Cushing's syndrome is caused by excess cortisol production from the adrenocortical gland. In corticotropin-independent Cushing's syndrome, the excess cortisol production is primarily attributed to an adrenocortical adenoma, in which the underlying molecular pathogenesis has been poorly understood. We report a hotspot mutation (L206R) in PRKACA, which encodes the catalytic subunit of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), in more than 50% of cases with adrenocortical adenomas associated with corticotropin-independent Cushing's syndrome. The L206R PRKACA mutant abolished its binding to the regulatory subunit of PKA (PRKAR1A) that inhibits catalytic activity of PRKACA, leading to constitutive, cAMP-independent PKA activation. These results highlight the major role of cAMP-independent activation of cAMP/PKA signaling by somatic mutations in corticotropin-independent Cushing's syndrome, providing insights into the diagnosis and therapeutics of this syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sato, Yusuke -- Maekawa, Shigekatsu -- Ishii, Ryohei -- Sanada, Masashi -- Morikawa, Teppei -- Shiraishi, Yuichi -- Yoshida, Kenichi -- Nagata, Yasunobu -- Sato-Otsubo, Aiko -- Yoshizato, Tetsuichi -- Suzuki, Hiromichi -- Shiozawa, Yusuke -- Kataoka, Keisuke -- Kon, Ayana -- Aoki, Kosuke -- Chiba, Kenichi -- Tanaka, Hiroko -- Kume, Haruki -- Miyano, Satoru -- Fukayama, Masashi -- Nureki, Osamu -- Homma, Yukio -- Ogawa, Seishi -- New York, N.Y. -- Science. 2014 May 23;344(6186):917-20. doi: 10.1126/science.1252328.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ; Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ; Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan. ; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. ; Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ; Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ; Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ; Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ; Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. sogawa-tky@umin.ac.jp homma-uro@umin.ac.jp. ; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. sogawa-tky@umin.ac.jp homma-uro@umin.ac.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855271" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenal Cortex Neoplasms/*genetics ; Adrenocortical Adenoma/*genetics ; Adrenocorticotropic Hormone/metabolism ; Animals ; Catalytic Domain/genetics ; Cushing Syndrome/*genetics/metabolism ; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/*genetics/metabolism ; DNA Mutational Analysis ; GTP-Binding Protein alpha Subunits/genetics ; HEK293 Cells ; Humans ; Mice ; Mutation ; NIH 3T3 Cells ; PC12 Cells ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carney, Joanne Padron -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):243. doi: 10.1126/science.1258492.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Joanne Padron Carney is the director of government relations at AAAS, Washington, DC. jcarney@aaas.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035462" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Communication ; *Federal Government ; Policy ; *Policy Making ; *Science ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 39
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carswell, Cally -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):154-6. doi: 10.1126/science.346.6206.154.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cally Carswell is a freelance science and environment writer in Santa Fe.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301598" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Pinus/*parasitology ; Plant Bark/*parasitology ; Trees/*parasitology ; United States ; *Weevils
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 40
    Publikationsdatum: 2014-11-15
    Beschreibung: Lightning plays an important role in atmospheric chemistry and in the initiation of wildfires, but the impact of global warming on lightning rates is poorly constrained. Here we propose that the lightning flash rate is proportional to the convective available potential energy (CAPE) times the precipitation rate. Using observations, the product of CAPE and precipitation explains 77% of the variance in the time series of total cloud-to-ground lightning flashes over the contiguous United States (CONUS). Storms convert CAPE times precipitated water mass to discharged lightning energy with an efficiency of 1%. When this proxy is applied to 11 climate models, CONUS lightning strikes are predicted to increase 12 +/- 5% per degree Celsius of global warming and about 50% over this century.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Romps, David M -- Seeley, Jacob T -- Vollaro, David -- Molinari, John -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):851-4. doi: 10.1126/science.1259100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth and Planetary Science, University of California, Berkeley, and Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. romps@berkeley.edu. ; Department of Earth and Planetary Science, University of California, Berkeley, and Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. ; Department of Atmospheric and Environmental Sciences, State University of New York at Albany, Albany, NY, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395536" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Convection ; *Global Warming ; *Lightning ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 41
    Publikationsdatum: 2014-11-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Francis S -- Heimer, Hakon -- Giedd, Jay N -- Lein, Edward S -- Sestan, Nenad -- Weinberger, Daniel R -- Casey, B J -- New York, N.Y. -- Science. 2014 Oct 31;346(6209):547-9. doi: 10.1126/science.1260497.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sackler Institute, Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA. ; Schizophrenia Research Forum, Brain and Behavior Research Foundation, Providence, RI 02906, USA. Banbury Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. ; Division of Child and Adolescent Psychiatry, University of California, San Diego, CA 92123, USA. ; Allen Institute for Brain Science, Seattle, WA 98103, USA. ; Department of Neurobiology and Psychiatry, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA. ; Lieber Institute for Brain Development, Baltimore, MD 21205, USA. Department of Psychiatry, Neurology, Neuroscience, and the Institute of Genomic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 20215, USA. ; Sackler Institute, Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA. bjc2002@med.cornell.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25359951" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; *Adolescent Behavior ; *Adolescent Development ; Age of Onset ; Brain/*growth & development/physiology ; *Early Medical Intervention ; Humans ; Mental Disorders/diagnosis/epidemiology/*prevention & control ; *Mental Health ; National Institutes of Health (U.S.)/economics ; Neuroimaging ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 42
    Publikationsdatum: 2014-02-08
    Beschreibung: We report that the oxytocin-mediated neuroprotective gamma-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of autism. During delivery and subsequently, hippocampal neurons in these models have elevated intracellular chloride levels, increased excitatory GABA, enhanced glutamatergic activity, and elevated gamma oscillations. Maternal pretreatment with bumetanide restored in offspring control electrophysiological and behavioral phenotypes. Conversely, blocking oxytocin signaling in naive mothers produced offspring having electrophysiological and behavioral autistic-like features. Our results suggest a chronic deficient chloride regulation in these rodent models of autism and stress the importance of oxytocin-mediated GABAergic inhibition during the delivery process. Our data validate the amelioration observed with bumetanide and oxytocin and point to common pathways in a drug-induced and a genetic rodent model of autism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tyzio, Roman -- Nardou, Romain -- Ferrari, Diana C -- Tsintsadze, Timur -- Shahrokhi, Amene -- Eftekhari, Sanaz -- Khalilov, Ilgam -- Tsintsadze, Vera -- Brouchoud, Corinne -- Chazal, Genevieve -- Lemonnier, Eric -- Lozovaya, Natalia -- Burnashev, Nail -- Ben-Ari, Yehezkel -- New York, N.Y. -- Science. 2014 Feb 7;343(6171):675-9. doi: 10.1126/science.1247190.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24503856" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Autistic Disorder/*chemically induced/*genetics/metabolism ; Behavior, Animal ; Bumetanide/administration & dosage ; Chlorides/metabolism ; *Cytoprotection ; Disease Models, Animal ; Female ; Fragile X Mental Retardation Protein/genetics ; Maternal-Fetal Exchange ; Mice ; Oxytocin/*metabolism ; Parturition ; Pregnancy ; Rats ; Valproic Acid/pharmacology ; gamma-Aminobutyric Acid/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 43
    Publikationsdatum: 2014-05-03
    Beschreibung: We demonstrate a technique for mapping brain activity that combines molecular specificity and spatial coverage using a neurotransmitter sensor detectable by magnetic resonance imaging (MRI). This molecular functional MRI (fMRI) method yielded time-resolved volumetric measurements of dopamine release evoked by reward-related lateral hypothalamic brain stimulation of rats injected with the neurotransmitter sensor. Peak dopamine concentrations and release rates were observed in the anterior nucleus accumbens core. Substantial dopamine transients were also present in more caudal areas. Dopamine-release amplitudes correlated with the rostrocaudal stimulation coordinate, suggesting participation of hypothalamic circuitry in modulating dopamine responses. This work provides a foundation for development and application of quantitative molecular fMRI techniques targeted toward numerous components of neural physiology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Taekwan -- Cai, Lili X -- Lelyveld, Victor S -- Hai, Aviad -- Jasanoff, Alan -- DP2-OD002114/OD/NIH HHS/ -- R01-DA02899/DA/NIDA NIH HHS/ -- R01-NS076462/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2014 May 2;344(6183):533-5. doi: 10.1126/science.1249380.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24786083" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bacterial Proteins/*chemistry/genetics ; Brain Mapping/*methods ; Contrast Media/*chemistry ; Cytochrome P-450 Enzyme System/*chemistry/genetics ; Dopamine/*metabolism ; Dopaminergic Neurons ; Magnetic Resonance Imaging/*methods ; Male ; Molecular Imaging/*methods ; NADPH-Ferrihemoprotein Reductase/*chemistry/genetics ; Nucleus Accumbens/*metabolism ; Rats ; Rats, Sprague-Dawley
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 44
    Publikationsdatum: 2014-03-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazer, David -- Kennedy, Ryan -- King, Gary -- Vespignani, Alessandro -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1203-5. doi: 10.1126/science.1248506.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lazer Laboratory, Northeastern University, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626916" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Centers for Disease Control and Prevention (U.S.) ; Data Collection/statistics & numerical data ; Data Interpretation, Statistical ; *Disease Outbreaks ; Humans ; Influenza, Human/*epidemiology ; Office Visits/statistics & numerical data/*trends ; Prognosis ; Social Media/*utilization ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 45
    Publikationsdatum: 2014-05-17
    Beschreibung: Neural circuits are shaped by elimination of early-formed redundant synapses during postnatal development. Retrograde signaling from postsynaptic cells regulates synapse elimination. In this work, we identified semaphorins, a family of versatile cell recognition molecules, as retrograde signals for elimination of redundant climbing fiber to Purkinje cell synapses in developing mouse cerebellum. Knockdown of Sema3A, a secreted semaphorin, in Purkinje cells or its receptor in climbing fibers accelerated synapse elimination during postnatal day 8 (P8) to P18. Conversely, knockdown of Sema7A, a membrane-anchored semaphorin, in Purkinje cells or either of its two receptors in climbing fibers impaired synapse elimination after P15. The effect of Sema7A involves signaling by metabotropic glutamate receptor 1, a canonical pathway for climbing fiber synapse elimination. These findings define how semaphorins retrogradely regulate multiple processes of synapse elimination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Uesaka, Naofumi -- Uchigashima, Motokazu -- Mikuni, Takayasu -- Nakazawa, Takanobu -- Nakao, Harumi -- Hirai, Hirokazu -- Aiba, Atsu -- Watanabe, Masahiko -- Kano, Masanobu -- New York, N.Y. -- Science. 2014 May 30;344(6187):1020-3. doi: 10.1126/science.1252514. Epub 2014 May 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. ; Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan. ; Laboratory of Animal Resources, Center for Disease Biology and Integrated Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. ; Department of Neurophysiology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan. ; Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. mkano-tky@m.u-tokyo.ac.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24831527" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, CD/genetics/*metabolism ; Brain/*growth & development/metabolism ; Gene Knockdown Techniques ; Mice ; Mice, Inbred C57BL ; Purkinje Cells/metabolism/*physiology ; RNA Interference ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/genetics/metabolism ; Semaphorin-3A/genetics/*metabolism ; Semaphorins/genetics/*metabolism ; Signal Transduction ; Synapses/genetics/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 46
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Underwood, Emily -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):149. doi: 10.1126/science.346.6206.149-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301593" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Geographic Information Systems ; Hippocampus/*cytology ; Humans ; Neurons/*physiology ; *Neurosciences ; *Nobel Prize ; Rats ; Spatial Behavior/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 47
    Publikationsdatum: 2014-06-21
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉H3Africa Consortium -- Rotimi, Charles -- Abayomi, Akin -- Abimiku, Alash'le -- Adabayeri, Victoria May -- Adebamowo, Clement -- Adebiyi, Ezekiel -- Ademola, Adebowale D -- Adeyemo, Adebowale -- Adu, Dwomoa -- Affolabi, Dissou -- Agongo, Godfred -- Ajayi, Samuel -- Akarolo-Anthony, Sally -- Akinyemi, Rufus -- Akpalu, Albert -- Alberts, Marianne -- Alonso Betancourt, Orlando -- Alzohairy, Ahmed Mansour -- Ameni, Gobena -- Amodu, Olukemi -- Anabwani, Gabriel -- Andersen, Kristian -- Arogundade, Fatiu -- Arulogun, Oyedunni -- Asogun, Danny -- Bakare, Rasheed -- Balde, Naby -- Baniecki, Mary Lynn -- Beiswanger, Christine -- Benkahla, Alia -- Bethke, Lara -- Boehnke, Micheal -- Boima, Vincent -- Brandful, James -- Brooks, Andrew I -- Brosius, Frank C -- Brown, Chester -- Bucheton, Bruno -- Burke, David T -- Burnett, Barrington G -- Carrington-Lawrence, Stacy -- Carstens, Nadia -- Chisi, John -- Christoffels, Alan -- Cooper, Richard -- Cordell, Heather -- Crowther, Nigel -- Croxton, Talishiea -- de Vries, Jantina -- Derr, Leslie -- Donkor, Peter -- Doumbia, Seydou -- Duncanson, Audrey -- Ekem, Ivy -- El Sayed, Ahmed -- Engel, Mark E -- Enyaru, John C K -- Everett, Dean -- Fadlelmola, Faisal M -- Fakunle, Eyitayo -- Fischbeck, Kenneth H -- Fischer, Anne -- Folarin, Onikepe -- Gamieldien, Junaid -- Garry, Robert F -- Gaseitsiwe, Simani -- Gbadegesin, Rasheed -- Ghansah, Anita -- Giovanni, Maria -- Goesbeck, Parham -- Gomez-Olive, F Xavier -- Grant, Donald S -- Grewal, Ravnit -- Guyer, Mark -- Hanchard, Neil A -- Happi, Christian T -- Hazelhurst, Scott -- Hennig, Branwen J -- Hertz-, Christiane -- Fowler -- Hide, Winston -- Hilderbrandt, Friedhelm -- Hugo-Hamman, Christopher -- Ibrahim, Muntaser E -- James, Regina -- Jaufeerally-Fakim, Yasmina -- Jenkins, Carolyn -- Jentsch, Ute -- Jiang, Pan-Pan -- Joloba, Moses -- Jongeneel, Victor -- Joubert, Fourie -- Kader, Mukthar -- Kahn, Kathleen -- Kaleebu, Pontiano -- Kapiga, Saidi H -- Kassim, Samar Kamal -- Kasvosve, Ishmael -- Kayondo, Jonathan -- Keavney, Bernard -- Kekitiinwa, Adeodata -- Khan, Sheik Humarr -- Kimmel, Paul -- King, Mary-Claire -- Kleta, Robert -- Koffi, Mathurin -- Kopp, Jeffrey -- Kretzler, Matthias -- Kumuthini, Judit -- Kyobe, Samuel -- Kyobutungi, Catherine -- Lackland, Daniel T -- Lacourciere, Karen A -- Landoure, Guida -- Lawlor, Rita -- Lehner, Thomas -- Lesosky, Maia -- Levitt, Naomi -- Littler, Katherine -- Lombard, Zane -- Loring, Jeanne F -- Lyantagaye, Sylvester -- Macleod, Annette -- Madden, Ebony B -- Mahomva, Chengetai R -- Makani, Julie -- Mamven, Manmak -- Marape, Marape -- Mardon, Graeme -- Marshall, Patricia -- Martin, Darren P -- Masiga, Daniel -- Mason, Robin -- Mate-Kole, Michael -- Matovu, Enock -- Mayige, Mary -- Mayosi, Bongani M -- Mbanya, Jean Claude -- McCurdy, Sheryl A -- McCarthy, Mark I -- McIlleron, Helen -- Mc'Ligeyo, S O -- Merle, Corrine -- Mocumbi, Ana Olga -- Mondo, Charles -- Moran, John V -- Motala, Ayesha -- Moxey-Mims, Marva -- Mpoloka, Wata Sununguko -- Msefula, Chisomo L -- Mthiyane, Thuli -- Mulder, Nicola -- Mulugeta, Gebregziab her -- Mumba, Dieuodonne -- Musuku, John -- Nagdee, Mo -- Nash, Oyekanmi -- Ndiaye, Daouda -- Nguyen, Anh Quynh -- Nicol, Mark -- Nkomazana, Oathokwa -- Norris, Shane -- Nsangi, Betty -- Nyarko, Alexander -- Nyirenda, Moffat -- Obe, Eileen -- Obiakor, Reginald -- Oduro, Abraham -- Ofori-Acquah, Solomon F -- Ogah, Okechukwu -- Ogendo, Stephen -- Ohene-Frempong, Kwaku -- Ojo, Akinlolu -- Olanrewaju, Timothy -- Oli, John -- Osafo, Charlotte -- Ouwe Missi Oukem-Boyer, Odile -- Ovbiagele, Bruce -- Owen, Andrew -- Owolabi, Mayowa Ojo -- Owolabi, Lukman -- Owusu-Dabo, Ellis -- Pare, Guillaume -- Parekh, Rulan -- Patterton, Hugh G -- Penno, Margaret B -- Peterson, Jane -- Pieper, Rembert -- Plange-Rhule, Jacob -- Pollak, Martin -- Puzak, Julia -- Ramesar, Rajkumar S -- Ramsay, Michele -- Rasooly, Rebekah -- Reddy, Shiksha -- Sabeti, Pardis C -- Sagoe, Kwamena -- Salako, Tunde -- Samassekou, Oumar -- Sandhu, Manjinder S -- Sankoh, Osman -- Sarfo, Fred Stephen -- Sarr, Marie -- Shaboodien, Gasnat -- Sidibe, Issa -- Simo, Gustave -- Simuunza, Martin -- Smeeth, Liam -- Sobngwi, Eugene -- Soodyall, Himla -- Sorgho, Hermann -- Sow Bah, Oumou -- Srinivasan, Sudha -- Stein, Dan J -- Susser, Ezra S -- Swanepoel, Carmen -- Tangwa, Godfred -- Tareila, Andrew -- Tastan Bishop, Ozlem -- Tayo, Bamidele -- Tiffin, Nicki -- Tinto, Halidou -- Tobin, Ekaete -- Tollman, Stephen Meir -- Traore, Mahamadou -- Treadwell, Marsha J -- Troyer, Jennifer -- Tsimako-Johnstone, Masego -- Tukei, Vincent -- Ulasi, Ifeoma -- Ulenga, Nzovu -- van Rooyen, Beverley -- Wachinou, Ablo Prudence -- Waddy, Salina P -- Wade, Alisha -- Wayengera, Misaki -- Whitworth, James -- Wideroff, Louise -- Winkler, Cheryl A -- Winnicki, Sarah -- Wonkam, Ambroise -- Yewondwos, Mengistu -- sen, Tadase -- Yozwiak, Nathan -- Zar, Heather -- 085349/Wellcome Trust/United Kingdom -- 095009/Wellcome Trust/United Kingdom -- 095201/Wellcome Trust/United Kingdom -- 098504/Wellcome Trust/United Kingdom -- 104111/Wellcome Trust/United Kingdom -- MC_U123292700/Medical Research Council/United Kingdom -- P20 MD006899/MD/NIMHD NIH HHS/ -- R01 AI104621/AI/NIAID NIH HHS/ -- RG/08/012/25941/British Heart Foundation/United Kingdom -- U01 HG007044/HG/NHGRI NIH HHS/ -- U41 HG006941/HG/NHGRI NIH HHS/ -- U54 AI110398/AI/NIAID NIH HHS/ -- U54 HG006938/HG/NHGRI NIH HHS/ -- U54 HG006939/HG/NHGRI NIH HHS/ -- U54 HG007479/HG/NHGRI NIH HHS/ -- UH2 HG007051/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2014 Jun 20;344(6190):1346-8. doi: 10.1126/science.1251546.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24948725" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa ; Disease/*genetics ; England ; Genetics, Medical/trends ; Genome-Wide Association Study/*trends ; Genomics/*trends ; Health ; Humans ; National Institutes of Health (U.S.) ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 48
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murray, Thomas H -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1208-10. doi: 10.1126/science.1248080.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Hastings Center, Garrison, New York, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626919" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Bioethical Issues ; Cell Nucleus/genetics ; DNA, Mitochondrial/genetics ; Embryo, Mammalian ; Guidelines as Topic ; Humans ; Insemination, Artificial ; Mitochondria/*genetics ; Mitochondrial Diseases/*genetics/*prevention & control ; Ovum ; Reproductive Techniques, Assisted/*ethics/legislation & jurisprudence ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Underwood, Emily -- New York, N.Y. -- Science. 2014 May 23;344(6186):820-1. doi: 10.1126/science.344.6186.820.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855250" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Developed Countries/*economics/statistics & numerical data ; Developing Countries/*economics/statistics & numerical data ; Income/*statistics & numerical data ; Socioeconomic Factors ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 50
    Publikationsdatum: 2014-02-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carmona, Richard -- New York, N.Y. -- Science. 2014 Feb 7;343(6171):589. doi: 10.1126/science.343.6171.589.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24503826" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Administration, Inhalation ; Adult ; Child ; *Device Approval ; Humans ; Nicotine/*administration & dosage ; Smoking/*epidemiology/*prevention & control ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 51
    Publikationsdatum: 2014-01-05
    Beschreibung: Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), Delta(9)-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation that could open an unforeseen approach for the treatment of cannabis intoxication and addiction.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057431/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057431/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vallee, Monique -- Vitiello, Sergio -- Bellocchio, Luigi -- Hebert-Chatelain, Etienne -- Monlezun, Stephanie -- Martin-Garcia, Elena -- Kasanetz, Fernando -- Baillie, Gemma L -- Panin, Francesca -- Cathala, Adeline -- Roullot-Lacarriere, Valerie -- Fabre, Sandy -- Hurst, Dow P -- Lynch, Diane L -- Shore, Derek M -- Deroche-Gamonet, Veronique -- Spampinato, Umberto -- Revest, Jean-Michel -- Maldonado, Rafael -- Reggio, Patricia H -- Ross, Ruth A -- Marsicano, Giovanni -- Piazza, Pier Vincenzo -- 260515/European Research Council/International -- DA-003934/DA/NIDA NIH HHS/ -- DA-03672/DA/NIDA NIH HHS/ -- DA-09789/DA/NIDA NIH HHS/ -- K05 DA021358/DA/NIDA NIH HHS/ -- R01 DA003934/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):94-8. doi: 10.1126/science.1243985.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM, Neurocentre Magendie, Physiopathologie de la Plasticite Neuronale, U862, F-33000 Bordeaux, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385629" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/*drug effects/metabolism ; Cannabinoid Receptor Antagonists/administration & dosage ; Cannabis/*toxicity ; Dronabinol/*toxicity ; Male ; Marijuana Abuse/drug therapy ; Mice ; Mice, Inbred C57BL ; Pregnenolone/*administration & dosage/*metabolism ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Receptor, Cannabinoid, CB1/*agonists/*antagonists & inhibitors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 52
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muller, Nicholas Z -- New York, N.Y. -- Science. 2014 Aug 22;345(6199):873-4. doi: 10.1126/science.1253506.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics and Environmental Studies Program, Middlebury College, Middlebury, VT 05753 USA. Faculty Research Fellow, National Bureau of Economic Research, Cambridge, MA 02138 USA. nmuller@middlebury.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25146270" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air Pollution/*economics ; Environment ; Greenhouse Effect/*economics ; Gross Domestic Product/*trends ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 53
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):404. doi: 10.1126/science.346.6208.404.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342775" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Coronavirus ; Federal Government ; Humans ; Influenza A Virus, H5N1 Subtype ; Mice ; Risk ; Security Measures ; United States ; Virology/*economics/*trends ; Virus Diseases/*prevention & control/*transmission
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-09-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2014 Sep 5;345(6201):1115. doi: 10.1126/science.345.6201.1115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25190776" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Biomedical Research ; Federal Government ; Humans ; Influenza A Virus, H5N1 Subtype/*pathogenicity ; Influenza A Virus, H7N9 Subtype/*pathogenicity ; Risk Management ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 55
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):150-1. doi: 10.1126/science.346.6206.150.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301595" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Age Factors ; Biomedical Research/*economics ; Humans ; National Institutes of Health (U.S.)/economics/legislation & jurisprudence ; Research Personnel/statistics & numerical data ; Research Support as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 56
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-06-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2014 Jun 27;344(6191):1464-7. doi: 10.1126/science.344.6191.1464.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24970074" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Climate Change ; Ecosystem ; Environmental Pollution ; *Natural Gas/economics/toxicity ; *Oil and Gas Fields ; United States ; Water Quality
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 57
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-07-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Jul 25;345(6195):366-7. doi: 10.1126/science.345.6195.366.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25061183" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Awards and Prizes ; Financing, Organized ; Humans ; National Institute of General Medical Sciences (U.S.)/economics ; National Institutes of Health (U.S.)/*economics ; Research Personnel/*economics ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 58
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1186-7. doi: 10.1126/science.343.6176.1186.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626907" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Budgets ; Federal Government ; Science/*economics ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 59
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-06-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Jun 20;344(6190):1327. doi: 10.1126/science.344.6190.1327.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24948712" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; *Health Status ; Humans ; National Institute of Child Health and Human Development (U.S.)/*trends ; *Patient Selection ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 60
    facet.materialart.
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):13. doi: 10.1126/science.343.6166.13.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385612" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Commerce/*economics ; Federal Government ; Investments/*legislation & jurisprudence ; Research/*economics ; Tax Exemption/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 61
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):350. doi: 10.1126/science.344.6182.350.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24763564" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Budgets ; Financing, Government ; *National Institutes of Health (U.S.)/economics/organization & administration ; Peer Review, Research ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 62
    facet.materialart.
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-06-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2014 Jun 6;344(6188):1070-1. doi: 10.1126/science.344.6188.1070.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24904132" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air Pollutants/*standards ; Air Pollution/*prevention & control ; Carbon Dioxide/*standards ; Global Warming/*prevention & control ; Greenhouse Effect/*prevention & control ; United States ; United States Environmental Protection Agency/legislation & jurisprudence
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 63
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grimm, David -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):988. doi: 10.1126/science.345.6200.988.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170127" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Accreditation ; Animal Welfare/*standards ; Animals ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 64
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grimm, David -- New York, N.Y. -- Science. 2014 May 2;344(6183):461. doi: 10.1126/science.344.6183.461.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24786056" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Analgesia ; Animals ; Anti-Inflammatory Agents/administration & dosage ; Biomedical Research/*standards ; Female ; Humans ; Male ; Mice ; *Odors ; Pain/*physiopathology/prevention & control ; Pain Measurement ; Pain Threshold ; Rats ; Sex Factors ; *Smell
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 65
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1301. doi: 10.1126/science.343.6177.1301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24653015" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Colorado ; *Ecosystem ; *Floods ; Groundwater ; Mexico ; *Rivers ; Salinity ; Trees/*growth & development ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 66
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gronewold, Andrew D -- Stow, Craig A -- New York, N.Y. -- Science. 2014 Mar 7;343(6175):1084-5. doi: 10.1126/science.1249978.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Oceanic and Atmospheric Administration (NOAA), Great Lakes Environmental Research Laboratory (GLERL), Ann Arbor, MI, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24604186" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Canada ; *Climate Change ; *Environmental Monitoring ; *Lakes ; United States ; *Water Resources
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 67
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-08
    Beschreibung: River networks evolve as migrating drainage divides reshape river basins and change network topology by capture of river channels. We demonstrate that a characteristic metric of river network geometry gauges the horizontal motion of drainage divides. Assessing this metric throughout a landscape maps the dynamic states of entire river networks, revealing diverse conditions: Drainage divides in the Loess Plateau of China appear stationary; the young topography of Taiwan has migrating divides driving adjustment of major basins; and rivers draining the ancient landscape of the southeastern United States are reorganizing in response to escarpment retreat and coastal advance. The ability to measure the dynamic reorganization of river basins presents opportunities to examine landscape-scale interactions among tectonics, erosion, and ecology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willett, Sean D -- McCoy, Scott W -- Perron, J Taylor -- Goren, Liran -- Chen, Chia-Yu -- New York, N.Y. -- Science. 2014 Mar 7;343(6175):1248765. doi: 10.1126/science.1248765.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geological Institute, Swiss Federal Institute of Technology, 8092 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24604204" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Climate ; Geologic Sediments ; Models, Theoretical ; *Rivers ; Soil ; Taiwan ; United States ; *Water Movements
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 68
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):361-3. doi: 10.1126/science.343.6169.361.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458620" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Chemically-Induced Disorders/*genetics ; DNA Methylation/drug effects ; *Epigenesis, Genetic ; Epigenomics/economics/trends ; Evolution, Molecular ; Female ; Humans ; Male ; Rats ; Reproduction/drug effects/genetics ; Sexual Behavior, Animal/drug effects ; Spermatozoa/*abnormalities/*drug effects
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 69
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):28-9. doi: 10.1126/science.344.6179.28.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700838" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biomedical Research/*economics ; Brain/growth & development ; Faculty ; Financing, Government ; National Institutes of Health (U.S.)/economics ; *Research Personnel/economics/education ; *Research Support as Topic ; United States ; Zebrafish
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 70
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Feb 21;343(6173):815. doi: 10.1126/science.1251932.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt is Editor-in-Chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24558130" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Canada ; *Conservation of Natural Resources ; *Extraction and Processing Industry ; *Fossil Fuels ; Petroleum ; *Renewable Energy ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 71
    Publikationsdatum: 2014-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalokairinou, Louiza -- Howard, Heidi Carmen -- Borry, Pascal -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):296-8. doi: 10.1126/science.1256396. Epub 2014 Oct 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Public Health and Primary Care, University of Leuven, B-3000 Leuven, Belgium. ; Center for Research Ethics and Bioethics, Uppsala University, SE-751 22 Uppsala, Sweden. ; Department of Public Health and Primary Care, University of Leuven, B-3000 Leuven, Belgium. pascal.borry@med.kuleuven.be.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324369" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Consumer Advocacy ; European Union ; Genetic Privacy/*legislation & jurisprudence ; Genetic Services/*legislation & jurisprudence ; Genetic Testing ; Genomics/*legislation & jurisprudence ; *Guidelines as Topic ; Humans ; Risk Assessment/classification ; United States ; United States Food and Drug Administration
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 72
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-06-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porter, John Edward -- New York, N.Y. -- Science. 2014 Jun 13;344(6189):1207. doi: 10.1126/science.1256929.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉John Edward Porter is a former U.S. congressman, a partner in the law firm of Hogan Lovells, and chair of Research!America.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24925988" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biomedical Research/*economics/*trends ; Budgets ; Capital Financing/*organization & administration/trends ; Humans ; *Information Dissemination ; National Institutes of Health (U.S.)/*economics ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 73
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-31
    Beschreibung: N-Methyl-D-aspartate (NMDA) receptors belong to the family of ionotropic glutamate receptors, which mediate most excitatory synaptic transmission in mammalian brains. Calcium permeation triggered by activation of NMDA receptors is the pivotal event for initiation of neuronal plasticity. Here, we show the crystal structure of the intact heterotetrameric GluN1-GluN2B NMDA receptor ion channel at 4 angstroms. The NMDA receptors are arranged as a dimer of GluN1-GluN2B heterodimers with the twofold symmetry axis running through the entire molecule composed of an amino terminal domain (ATD), a ligand-binding domain (LBD), and a transmembrane domain (TMD). The ATD and LBD are much more highly packed in the NMDA receptors than non-NMDA receptors, which may explain why ATD regulates ion channel activity in NMDA receptors but not in non-NMDA receptors.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113085/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113085/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karakas, Erkan -- Furukawa, Hiro -- MH085926/MH/NIMH NIH HHS/ -- R01 GM105730/GM/NIGMS NIH HHS/ -- R01 MH085926/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2014 May 30;344(6187):992-7. doi: 10.1126/science.1251915.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, W. M. Keck Structural Biology Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA. ; Cold Spring Harbor Laboratory, W. M. Keck Structural Biology Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA. furukawa@cshl.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876489" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Binding Sites ; Calcium/chemistry/metabolism ; Crystallography, X-Ray ; Protein Multimerization ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Rats ; Receptors, N-Methyl-D-Aspartate/*chemistry/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-06-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glaeser, Edward L -- Shleifer, Andrei -- New York, N.Y. -- Science. 2014 Jun 13;344(6189):1233. doi: 10.1126/science.1256540.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Harvard University, Boston, MA, USA. ; Harvard University, Boston, MA, USA. shleifer@fas.harvard.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24926006" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Behavior ; Economics/*history ; History, 20th Century ; History, 21st Century ; Humans ; Investments/history ; Nobel Prize ; Racism/history/psychology ; Sociology/*history ; Training Support/history ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2014 May 23;344(6186):826-7. doi: 10.1126/science.344.6186.826.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855253" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Capitalism ; Databases, Factual ; France ; History, 18th Century ; History, 21st Century ; Income/history/statistics & numerical data/*trends ; Income Tax/history/statistics & numerical data/*trends ; Socioeconomic Factors/history ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):27. doi: 10.1126/science.344.6179.27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700837" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biochemistry ; Biomedical Research/*economics ; Financing, Government ; National Institutes of Health (U.S.)/economics ; Peer Review, Research ; Research Personnel/*economics ; *Research Support as Topic ; United States ; United States Government Agencies/economics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 77
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-11-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernstein, Rachel -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):798. doi: 10.1126/science.346.6211.798.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395513" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Career Choice ; Engineering/manpower ; Faculty ; Female ; Humans ; Mathematics/manpower ; Physics/manpower ; Science/*manpower ; *Sexism ; United States ; Universities ; *Women
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pringle, Heather -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):364-7. doi: 10.1126/science.343.6169.364.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458621" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Commerce ; Dinosaurs ; *Fossils ; Horses ; United States
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-03-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1194-7. doi: 10.1126/science.343.6176.1194.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626911" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bacteria ; Beetles ; Cough/microbiology ; Humans ; Plant Leaves ; Rats ; Skin ; Sneezing ; Surface Tension ; Viruses ; Water/*chemistry ; *Wettability
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-24
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159256/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159256/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xie, Yu -- R24 HD041028/HD/NICHD NIH HHS/ -- R24HD041028/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2014 May 23;344(6186):809-10. doi: 10.1126/science.1252743.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA. Center for Social Research, Peking University, Beijing 100871, China. yuxie@umich.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855244" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Democracy ; Employment/*statistics & numerical data ; Internationality ; Reward ; Science/*economics/*trends ; Socioeconomic Factors ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 81
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-01-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennel, Charles -- Dressler, Alan -- New York, N.Y. -- Science. 2014 Jan 10;343(6167):140-1. doi: 10.1126/science.1244231.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24408421" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cost-Benefit Analysis ; Planning Techniques ; Space Flight/*economics/*statistics & numerical data ; *Uncertainty ; United States ; United States National Aeronautics and Space Administration/economics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 82
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):408-9. doi: 10.1126/science.346.6208.408-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342780" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Capital Financing/trends ; *Federal Government ; National Institutes of Health (U.S.)/*economics ; *Policy ; Science/*economics ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):408-9. doi: 10.1126/science.346.6208.408-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342779" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Budgets ; *Federal Government ; Peer Review ; *Policy ; Science/*economics ; United States ; Water Resources
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):152-3. doi: 10.1126/science.346.6206.152.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301597" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Access to Information ; *Financing, Government ; *Foundations ; *Peer Review, Research ; Science/*economics ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-09-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Sep 19;345(6203):1442. doi: 10.1126/science.345.6203.1442.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25237083" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Budgets ; *Federal Government ; *Policy ; Research/economics ; Science/*economics ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Aug 8;345(6197):608. doi: 10.1126/science.345.6197.608.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25104363" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Censuses ; Costs and Cost Analysis ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 87
    Publikationsdatum: 2014-07-19
    Beschreibung: Cytoplasmic dynein is a molecular motor that transports a large variety of cargoes (e.g., organelles, messenger RNAs, and viruses) along microtubules over long intracellular distances. The dynactin protein complex is important for dynein activity in vivo, but its precise role has been unclear. Here, we found that purified mammalian dynein did not move processively on microtubules in vitro. However, when dynein formed a complex with dynactin and one of four different cargo-specific adapter proteins, the motor became ultraprocessive, moving for distances similar to those of native cargoes in living cells. Thus, we propose that dynein is largely inactive in the cytoplasm and that a variety of adapter proteins activate processive motility by linking dynactin to dynein only when the motor is bound to its proper cargo.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224444/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224444/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKenney, Richard J -- Huynh, Walter -- Tanenbaum, Marvin E -- Bhabha, Gira -- Vale, Ronald D -- F32GM096484/GM/NIGMS NIH HHS/ -- R01 GM097312/GM/NIGMS NIH HHS/ -- R01GM097312/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):337-41. doi: 10.1126/science.1254198. Epub 2014 Jun 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA. ; Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA. vale@ucsf.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035494" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adaptor Proteins, Signal Transducing/*metabolism ; Animals ; Cytoplasmic Dyneins/chemistry/*metabolism ; Humans ; Mice ; Microtubule-Associated Proteins/*metabolism ; Microtubules/chemistry/*metabolism ; Motion ; Protein Transport ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-05-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 May 30;344(6187):960-1. doi: 10.1126/science.344.6187.960.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876474" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Climate Change ; Federal Government ; Foundations/*legislation & jurisprudence ; Research/economics ; Research Support as Topic/*economics ; Science/*economics ; Technology/*economics ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-02-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Feb 14;343(6172):718. doi: 10.1126/science.343.6172.718.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24531947" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Annual Reports as Topic ; Engineering/economics/*trends ; Foundations ; Policy Making ; Science/economics/*trends ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 90
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-11-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Nov 21;346(6212):895. doi: 10.1126/science.aaa1728.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt Editor-in-Chief Science Journals.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25414278" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Data Curation ; *Schools ; Science/*education ; Students ; United States ; Volunteers
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 91
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-08-12
    Beschreibung: Ionotropic glutamate receptors (iGluRs) mediate most excitatory neurotransmission in the central nervous system and function by opening their ion channel in response to binding of agonist glutamate. Here, we report a structure of a homotetrameric rat GluA2 receptor in complex with partial agonist (S)-5-nitrowillardiine. Comparison of this structure with the closed-state structure in complex with competitive antagonist ZK 200775 suggests conformational changes that occur during iGluR gating. Guided by the structures, we engineered disulfide cross-links to probe domain interactions that are important for iGluR gating events. The combination of structural information, kinetic modeling, and biochemical and electrophysiological experiments provides insight into the mechanism of iGluR gating.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383034/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383034/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yelshanskaya, Maria V -- Li, Minfen -- Sobolevsky, Alexander I -- NS083660/NS/NINDS NIH HHS/ -- P41 GM103403/GM/NIGMS NIH HHS/ -- P41 GM111244/GM/NIGMS NIH HHS/ -- R01 NS083660/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1070-4. doi: 10.1126/science.1256508. Epub 2014 Aug 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA. ; Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA. as4005@columbia.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25103407" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cross-Linking Reagents/chemistry ; Crystallography, X-Ray ; Cysteine/chemistry ; Glutamic Acid/pharmacology ; HEK293 Cells ; Humans ; *Ion Channel Gating ; Models, Chemical ; Organophosphonates/chemistry/pharmacology ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Pyrimidinones/*pharmacology ; Quinoxalines/chemistry/pharmacology ; Rats ; Receptors, AMPA/*agonists/*chemistry/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-12-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- Malakoff, David -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1437-8. doi: 10.1126/science.346.6216.1437.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525219" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Budgets ; Organizations ; Science/*economics ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 93
    Publikationsdatum: 2014-01-05
    Beschreibung: In 2008, Oregon initiated a limited expansion of a Medicaid program for uninsured, low-income adults, drawing names from a waiting list by lottery. This lottery created a rare opportunity to study the effects of Medicaid coverage by using a randomized controlled design. By using the randomization provided by the lottery and emergency-department records from Portland-area hospitals, we studied the emergency department use of about 25,000 lottery participants over about 18 months after the lottery. We found that Medicaid coverage significantly increases overall emergency use by 0.41 visits per person, or 40% relative to an average of 1.02 visits per person in the control group. We found increases in emergency-department visits across a broad range of types of visits, conditions, and subgroups, including increases in visits for conditions that may be most readily treatable in primary care settings.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955206/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955206/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubman, Sarah L -- Allen, Heidi L -- Wright, Bill J -- Baicker, Katherine -- Finkelstein, Amy N -- P30 AG012810/AG/NIA NIH HHS/ -- P30AG012810/AG/NIA NIH HHS/ -- R01 AG034151/AG/NIA NIH HHS/ -- R01AG0345151/AG/NIA NIH HHS/ -- RC2 AG036631/AG/NIA NIH HHS/ -- RC2AGO36631/RC/CCR NIH HHS/ -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):263-8. doi: 10.1126/science.1246183. Epub 2014 Jan 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Bureau of Economic Research (NBER), Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385603" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Ambulatory Care/statistics & numerical data ; Emergency Service, Hospital/*utilization ; Female ; Humans ; Inpatients/statistics & numerical data ; Insurance, Health ; Male ; Medicaid/*economics ; *Medically Uninsured ; Oregon ; Poverty ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 94
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-11-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- Malakoff, David -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):796-7. doi: 10.1126/science.346.6211.796.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395511" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Climate Change ; Federal Government ; *Politics ; *Science ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 95
    Publikationsdatum: 2014-01-25
    Beschreibung: Little is known about how microcircuits are organized in layer 2 of the medial entorhinal cortex. We visualized principal cell microcircuits and determined cellular theta-rhythmicity in freely moving rats. Non-dentate-projecting, calbindin-positive pyramidal cells bundled dendrites together and formed patches arranged in a hexagonal grid aligned to layer 1 axons, parasubiculum, and cholinergic inputs. Calbindin-negative, dentate-gyrus-projecting stellate cells were distributed across layer 2 but avoided centers of calbindin-positive patches. Cholinergic drive sustained theta-rhythmicity, which was twofold stronger in pyramidal than in stellate neurons. Theta-rhythmicity was cell-type-specific but not distributed as expected from cell-intrinsic properties. Layer 2 divides into a weakly theta-locked stellate cell lattice and spatiotemporally highly organized pyramidal grid. It needs to be assessed how these two distinct principal cell networks contribute to grid cell activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ray, Saikat -- Naumann, Robert -- Burgalossi, Andrea -- Tang, Qiusong -- Schmidt, Helene -- Brecht, Michael -- New York, N.Y. -- Science. 2014 Feb 21;343(6173):891-6. doi: 10.1126/science.1243028. Epub 2014 Jan 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bernstein Center for Computational Neuroscience, Humboldt University of Berlin, Philippstrasse 13 Haus 6, 10115 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24457213" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylcholine/metabolism ; Animals ; Calbindins/analysis/metabolism ; Dendrites/physiology ; Dentate Gyrus/physiology ; Entorhinal Cortex/*cytology/metabolism/physiology ; Female ; Male ; *Nerve Net ; Pyramidal Cells/metabolism/*physiology/*ultrastructure ; Rats ; Rats, Wistar ; Staining and Labeling ; *Theta Rhythm
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reperant, L A -- van de Burgwal, L H M -- Claassen, E -- Osterhaus, A D M E -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):433-4. doi: 10.1126/science.346.6208.433-b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Artemis One Health Research Foundation, 3584 CL Utrecht, Netherlands. Department of Viroscience, Erasmus MC, 3000 CA Rotterdam, Netherlands. ; Athena Institute, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, Netherlands. ; Artemis One Health Research Foundation, 3584 CL Utrecht, Netherlands. Athena Institute, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, Netherlands. ; Artemis One Health Research Foundation, 3584 CL Utrecht, Netherlands. Department of Viroscience, Erasmus MC, 3000 CA Rotterdam, Netherlands. a.osterhaus@erasmusmc.nl.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342793" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antiviral Agents/therapeutic use ; Communicable Disease Control/economics/*methods ; Drug Discovery ; Ebola Vaccines/administration & dosage ; *Ebolavirus ; Hemorrhagic Fever, Ebola/drug therapy/epidemiology/*prevention & control ; Humans ; National Institute of Allergy and Infectious Diseases (U.S.) ; Private Sector/economics ; Public Sector/economics ; Public-Private Sector Partnerships/*economics ; United States ; Vaccination
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-04-20
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206184/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206184/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dominici, Francesca -- Greenstone, Michael -- Sunstein, Cass R -- R01 ES012054/ES/NIEHS NIH HHS/ -- R01 ES019560/ES/NIEHS NIH HHS/ -- R21 ES020152/ES/NIEHS NIH HHS/ -- R21 ES02147/ES/NIEHS NIH HHS/ -- R21 ES022585/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2014 Apr 18;344(6181):257-9. doi: 10.1126/science.1247348.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24744361" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air Pollutants/*adverse effects ; Air Pollution/adverse effects/*legislation & jurisprudence/prevention & control ; Confounding Factors (Epidemiology) ; Government Regulation ; Humans ; Models, Statistical ; Observational Studies as Topic ; Particulate Matter/*adverse effects ; *Public Health/legislation & jurisprudence ; Public Policy ; Research Design ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 98
    Publikationsdatum: 2014-02-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brandt, A R -- Heath, G A -- Kort, E A -- O'Sullivan, F -- Petron, G -- Jordaan, S M -- Tans, P -- Wilcox, J -- Gopstein, A M -- Arent, D -- Wofsy, S -- Brown, N J -- Bradley, R -- Stucky, G D -- Eardley, D -- Harriss, R -- New York, N.Y. -- Science. 2014 Feb 14;343(6172):733-5. doi: 10.1126/science.1247045.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford University, Stanford, CA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24531957" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Atmosphere/*chemistry ; Decision Making ; *Global Warming ; Methane/*analysis ; Natural Gas/*analysis ; *Policy Making ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
    Publikationsdatum: 2014-08-16
    Beschreibung: The rules governing the formation of spatial maps in the hippocampus have not been determined. We investigated the large-scale structure of place field activity by recording hippocampal neurons in rats exploring a previously unencountered 48-meter-long track. Single-cell and population activities were well described by a two-parameter stochastic model. Individual neurons had their own characteristic propensity for forming fields randomly along the track, with some cells expressing many fields and many exhibiting few or none. Because of the particular distribution of propensities across cells, the number of neurons with fields scaled logarithmically with track length over a wide, ethological range. These features constrain hippocampal memory mechanisms, may allow efficient encoding of environments and experiences of vastly different extents and durations, and could reflect general principles of population coding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rich, P Dylan -- Liaw, Hua-Peng -- Lee, Albert K -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Aug 15;345(6198):814-7. doi: 10.1126/science.1255635. Epub 2014 Aug 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA. Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK. richp@janelia.hhmi.org leea@janelia.hhmi.org. ; Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA. ; Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA. richp@janelia.hhmi.org leea@janelia.hhmi.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25124440" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials ; Animals ; Brain Mapping ; CA1 Region, Hippocampal/cytology/*physiology ; Electrodes, Implanted ; Exploratory Behavior ; Male ; Maze Learning ; Memory/physiology ; Orientation ; Poisson Distribution ; Pyramidal Cells/*physiology ; Rats ; Rats, Long-Evans ; *Space Perception
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 100
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2014-12-06
    Beschreibung: Every day, acts of violence injure more than 6000 people in the United States. Despite decades of social science arguing that joblessness among disadvantaged youth is a key cause of violent offending, programs to remedy youth unemployment do not consistently reduce delinquency. This study tests whether summer jobs, which shift focus from remediation to prevention, can reduce crime. In a randomized controlled trial among 1634 disadvantaged high school youth in Chicago, assignment to a summer jobs program decreases violence by 43% over 16 months (3.95 fewer violent-crime arrests per 100 youth). The decline occurs largely after the 8-week intervention ends. The results suggest the promise of using low-cost, well-targeted programs to generate meaningful behavioral change, even with a problem as complex as youth violence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heller, Sara B -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1219-23. doi: 10.1126/science.1257809.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Criminology, University of Pennsylvania, Philadelphia, PA, USA. University of Chicago Crime Lab, Chicago, IL, USA. hellersa@sas.upenn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477459" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Crime Victims ; Employment/*statistics & numerical data ; Female ; Humans ; Male ; Poverty/*statistics & numerical data ; Seasons ; United States ; Violence/*prevention & control/statistics & numerical data
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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