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  • Cell Line  (20)
  • American Association for the Advancement of Science (AAAS)  (20)
  • American Chemical Society
  • 1980-1984  (20)
  • 1925-1929
  • 1920-1924
  • 1980  (20)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (20)
  • American Chemical Society
Years
  • 1980-1984  (20)
  • 1925-1929
  • 1920-1924
Year
  • 1
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    T-1 cells are HeLa and not of normal human kidney origin (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson-Rees, W A -- Flandermeyer, R R -- Daniels, D W -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):719-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394535" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Chromosome Banding ; HLA Antigens/analysis ; HeLa Cells/*cytology/immunology ; Humans ; Karyotyping ; Kidney/*cytology/immunology ; Metaphase
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: The human genes for growth hormone (GH), chorionic somatomammotropin (CSH), and a third growth hormone-like gene (GHL) have been located on chromosome 17 in humans. DNA fragments of 2.6, 2.8, and 9.5 kilobase pairs containing GH, CSH, and GHL, respectively, were identified in human genomic DNA, and a 7.5-kilobase DNA fragment related to growth hormone DNA sequences was found in mouse cells. In somatic hybrids of human and mouse cells containing reduced numbers of human chromosomes, but a normal complement of mouse chromosomes, the mouse, 7.5-kolobase DNA fragment was always present, whereas the 2.6-, 2.8-, and 9.5-kilobase human fragments were present only when human chromosome 17 was also present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owerbach, D -- Rutter, W J -- Martial, J A -- Baxter, J D -- Shows, T B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):289-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384802" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; *Chromosomes, Human, 16-18 ; *DNA/metabolism ; *Genes ; Growth Hormone/*biosynthesis ; Humans ; Hybrid Cells/metabolism ; Mice ; Placental Lactogen/*biosynthesis ; Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Estrogen and the growth of breast cancer: new evidence suggests indirect action (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: The growth of the MCF-7 human breast cancer cell line is unresponsive to the presence of estrogen in culture media. Paradoxically, in nude mice, growth of these cells and formation of solid tumors are dependent on estrogen. Tumors fail to develop in ovariectomized mice, but do develop in intact mice and in ovariectomized mice given estrogen. Primary cultures derived from MCF-7 tumors revert to unresponsiveness to estrogen. However, when these cultures are again transplanted into nude mice, estrogen is required for tumor formation. The continuous culture, the solid tumor, and the primary cultures therefrom have similar estrogen-binding capacities and affinities. These results indicate that mammary carcinoma cell growth in vivo is subject to inhibition that can be overcome by estrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shafie, S M -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):701-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6994231" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/metabolism/*physiopathology ; Castration ; Cell Division/drug effects ; Cell Line ; Cytosol/metabolism ; Estradiol/metabolism/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Receptors, Estrogen/metabolism ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Hemoglobin switching: a cellular model (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Regulation of hemoglobin synthesis depends in part on the population of cells available for erythroid differentiation. Mouse erythroleukemia cells were cloned, and the clones were induced with dimethyl sulfoxide to test the relative induction of beta minor and beta major synthesis. Cells of line 745 produced approximately 35 percent beta minor after induction, and 39 clones of line 745 produced from 23 to 61 percent beta minor. Further subcloning of the clone that produced 61 percent beta minor led to three subclones, all of which produced more than 90 percent beta minor. Thus one kind of hemoglobin regulation occurs at the cellular level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alter, B P -- Goff, S C -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):647-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6928071" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Line ; Clone Cells/metabolism ; Dimethyl Sulfoxide/pharmacology ; Globins/*biosynthesis/genetics ; Leukemia, Erythroblastic, Acute/metabolism ; Mice
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: When mammalian cell cultures are exposed for 2 hours to (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is 40 to 90 times greater than that of nuclear DNA. Evidence is presented that this reflects the lipophilic character of the derivative and the very high ratio of lipid to DNA in mitochondria. These results suggest that mitochondrial DNA may be an important cellular target of chemical carcinogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Backer, J M -- Weinstein, I B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):297-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6770466" target="_blank"〉PubMed〈/a〉
    Keywords: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide ; Animals ; Benzopyrenes/*metabolism ; Cell Line ; Cell Nucleus/metabolism ; DNA Replication/drug effects ; DNA, Mitochondrial/*metabolism ; Embryo, Mammalian ; Embryo, Nonmammalian ; L Cells (Cell Line) ; Liposomes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    The case of the unmentioned malignancy (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1229-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434022" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Survival/radiation effects ; Cell Transformation, Neoplastic/radiation effects ; Dose-Response Relationship, Radiation ; Gamma Rays ; Humans ; Neoplasms, Radiation-Induced/*etiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Vertebrate cells express protozoan antigen after hybridization (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-11
    Description: Epimastigotes, the invertebrate host stage of Trypanosoma cruzi, the protozoan parasite causing Chagas' disease in man, were fused with vertebrate cells by using polyethylene glycol. Hybrid cells were selected on the basis of T. cruzi DNA complementation of biochemical deficiencies in the vertebrate cells. Some clones of the hybrid cells expressed T. cruzi-specific antigen. It might be possible to use selected antigens obtained from the hybrids as vaccines for immunodiagnosis or for elucidation of the pathogenesis of Chagas' disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crane, M S -- Dvorak, J A -- New York, N.Y. -- Science. 1980 Apr 11;208(4440):194-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6987737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antigens/isolation & purification ; *Cell Fusion ; Cell Line ; Clone Cells ; Hybrid Cells/*immunology ; Hybridization, Genetic ; Mammals ; Polyethylene Glycols ; Trypanosoma cruzi/genetics/*immunology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Asymmetrically permeable membrane channels in cell junction (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-15
    Description: Asymmetric membrane junctions were formed in culture by pairing two cell types which, in their respective homologous junctions, have cell-cell channels of different permselectivities. The channels in the asymmetric junction, presumably made of unequal channel precursors, displayed directional permselectivity; fluorescent labeled glutamic acid (700 daltons), but not smaller and less polar permeant molecules, traversed the junction more readily in one direction than in the other. The favored direction was the one where the permeant passed first through the cell membrane that would have the less restrictive channels in a homologous junction. This directional selectivity requires no electric field across the junction and is thus distinct from a rectifying junction. The physiological potential of such directional molecular sieving for partitioning communication between tissue cells of different function and developmental fate are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J L -- Loewenstein, W R -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):771-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352287" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; *Cell Communication ; Cell Line ; Cell Membrane Permeability ; Fluorescent Dyes ; Intercellular Junctions/*physiology ; Ion Channels/*physiology/ultrastructure ; Membrane Potentials ; Mice
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors. The altered receptors exhibit agonist binding properties similar to those of receptors that are "uncoupled" from adenylate cyclase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harden, T K -- Cotton, C U -- Waldo, G L -- Lutton, J K -- Perkins, J P -- GM 25163/GM/NIGMS NIH HHS/ -- HL 22490/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct;210(4468):441-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254143" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Astrocytoma ; Cell Line ; Centrifugation, Density Gradient ; Concanavalin A/pharmacology ; Endocytosis ; Humans ; Isoproterenol/*metabolism ; Protein Conformation ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism ; Time Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Carcinogenic activity of particulate nickel compounds is proportional to their cellular uptake (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Particles (less than or equal to 5 micrometers) of the potent carcinogen crystalline nickel subsulfide were actively phagocytized by cultures of Syrian hamster embryo cells and Chinese hamster ovary cells. Cells did not take up significant quantities of similar-sized particles of the noncarcinogen amorphous nickel monosulfide. The carcinogenic activity of this and other metal compounds appears to be proportional to their cellular uptake.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Costa, M -- Mollenhauer, H H -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):515-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394519" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; *Carcinogens ; Cell Line ; Cricetinae ; Cricetulus ; Drug Evaluation, Preclinical/methods ; Embryo, Mammalian ; Female ; Mesocricetus ; Nickel/*metabolism/toxicity ; Ovary ; Sulfides/metabolism/toxicity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Cell variants showing differential susceptibility to ultraviolet light--induced transformation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Six variant clones isolated from a subclone of BALB/3T3-A31 clone were classified into three groups according to their different susceptibilities to cell transformation by ultraviolet light irradiation: highly susceptible, intermediately susceptible, and resistant. All variant clones showed similar susceptibility to cytotoxic effects induced by ultraviolet light.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kakunaga, T -- Crow, J D -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):505-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394516" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/*radiation effects ; Clone Cells ; Dose-Response Relationship, Radiation ; Genetic Variation ; Mice ; Transformation, Genetic/*radiation effects ; *Ultraviolet Rays
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Hybridomas revisited (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: In the report by John C. Behrendt et al. "Aeromagnetic and radio echo ice-sounding measurements show much greater area of the Dufek Intrusion, Antarctica" (29 Aug., p. 1014), the word "expedition" should have read "exploitation" in line 13 of the first paragraph on page 1014. Also, in line 2 of the next to last paragraph on page 1016, "50 to 60 cm/sec(2)" should have read "50 to 60 (cm sec(2)) x 10(-3)."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koprowski, H -- Croce, C -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):248.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423184" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antibodies, Viral ; Cell Line ; *Clone Cells ; Mice ; *Patents as Topic ; Plasmacytoma/immunology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Assignment of the murine interferon sensitivity and cytoplasmic superoxide dismutase genes to chromosome 16 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: Both hybrids of mouse and human microcells and whole cell hybrids generated by the fusion of primary mouse cells and SV40-transformed human fibroblasts were used to establish the syntenic association of the murine cytoplasmic superoxide dismutase and the interferon sensitivity genes on mouse chromosome 16. This assignment adds two new markers to chromosome 16 and provides another example of an evolutionarily conserved linkage. This finding also provides an animal model both for cellular responsiveness to interferon and for Down's syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, P F -- Slate, D L -- Lawyer, F C -- Ruddle, F H -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):285-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6155698" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Viral ; *Chromosomes, Human, 16-18 ; *Genes ; Humans ; Hybrid Cells/drug effects/*physiology ; Interferons/*pharmacology ; Karyotyping ; Mice ; Simian virus 40 ; Superoxide Dismutase/*genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Time: a new parameter for kinetic measurements in flow cytometry (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: The measure of time was used as an additional parameter on an existing flow cytometer to study the kinetics of enzyme activities and cell-stain interactions. By correlating all fluorescent signals from single cells with time, the dynamics of a reaction can be followed for several minutes. This advanced application of flow cytometry is easily implemented and can be incorporated into any flow cytometer that has two-parameter analysis capability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, J C -- Swartzendruber, D E -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):199-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6153131" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured/enzymology ; Computers ; Cricetinae ; *Cytological Techniques ; DNA/metabolism ; Esterases/metabolism ; Kinetics ; Mice ; Spectrometry, Fluorescence/methods ; Staining and Labeling
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    University and drug firm battle over billion-dollar gene (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1980 Sep 26;209(4464):1492-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159679" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Drug Industry ; Humans ; Interferons/biosynthesis/*genetics ; *Jurisprudence ; Leukemia, Myeloid, Acute/pathology ; Universities
    Print ISSN: 0036-8075
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  • 16
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    Modulation of epidermal growth factor receptors on 3T3 cells by platelet-derived growth factor (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-19
    Description: Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors. These data suggest a common cellular internalization mechanism for the receptors for both hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wrann, M -- Fox, C F -- Ross, R -- AM-25826/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 19;210(4476):1363-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Blood Platelets/*physiology ; Cell Line ; Endocytosis ; Epidermal Growth Factor/*metabolism ; Growth Substances/*pharmacology ; Mice ; Peptides/*metabolism/*pharmacology ; Platelet-Derived Growth Factor ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/*drug effects/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    Factors influencing the inhibitory effect of selenium on mice inoculated with Ehrlich ascites tumor cells (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: Selenium, administered to mice with Ehrlich ascites tumors, effectively limited tumor growth. The response was dependent on the chemical form and dose of selenium administered. At the doses administered, there were no detectable adverse effects to the host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greeder, G A -- Milner, J A -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):825-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7406957" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma, Ehrlich Tumor/*drug therapy/pathology ; Cell Line ; Cell Membrane Permeability ; Cystine/analogs & derivatives ; Dose-Response Relationship, Drug ; Male ; Mice ; Neoplasm Transplantation ; Selenium/*administration & dosage/metabolism/therapeutic use ; Selenomethionine/administration & dosage
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  • 18
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    Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Analysis of the cell culture fluid from two new human hepatoma-derived cell lines reveals that 17 of the major human plasma proteins are synthesized and secreted by these cells. One of these cell lines, Hep 3B, also produces the two major polypeptides of the hepatitis B virus surface antigen. When Hep 3B in injected into athymic mice, metastatic hepatocellular carcinomas appear. These cell lines provide experimental models for investigation of plasma protein biosynthesis and the relation of the hepatitis B viru genome to tumorigenicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knowles, B B -- Howe, C C -- Aden, D P -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):497-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6248960" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Proteins/*secretion ; Carcinoma, Hepatocellular/immunology/*secretion ; Cell Line ; Electrophoresis, Polyacrylamide Gel ; Hepatitis B Surface Antigens/*analysis ; Humans ; Immunodiffusion ; Liver Neoplasms/immunology/*secretion
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 19
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    Prostaglandin A compounds as antiviral agents (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-29
    Description: Prostaglandins of the A series strongly inhibit the production of Sendai virus in African green monkey kidney cells and are able to prevent the establishment of persistent infection ("carrier" state). This action is specific for prostaglandin A and is not due to alteration in the host cell metabolism or in the virus infectivity. The possibility that this effect is mediated by interferon is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santoro, M G -- Benedetto, A -- Carruba, G -- Garaci, E -- Jaffe, B M -- New York, N.Y. -- Science. 1980 Aug 29;209(4460):1032-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6157190" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/pharmacology ; Cell Line ; Dose-Response Relationship, Drug ; Haplorhini ; Interferons/pharmacology ; Parainfluenza Virus 1, Human/*drug effects ; Prostaglandins/pharmacology ; Prostaglandins A/*pharmacology ; Structure-Activity Relationship ; Thromboxanes/pharmacology ; Virus Replication/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 20
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    Amino terminal sequence of the major component of human lymphoblastoid interferon (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-01
    Description: Homogeneous human lymphoblastoid interferon with an apparent molecular size of 18,500 daltons was characterized by its amino acid composition. Analysis of the amino terminal sequence by Edman degradation indicates that the sequence is unique.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zoon, K C -- Smith, M E -- Bridgen, P J -- Anfinsen, C B -- Hunkapiller, M W -- Hood, L E -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):527-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352260" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amino Acids/analysis ; Cell Line ; Humans ; *Interferons ; Lymphocytes/*analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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