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  • Cham :Springer International Publishing :  (381)
  • Berlin ; Heidelberg : Springer
  • Ottawa : Geological Survey of Canada
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  • 1
    Keywords: Immunology. ; Medicine History. ; Medicine Research. ; Biology Research. ; Immunology. ; History of Medicine. ; Biomedical Research.
    Description / Table of Contents: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Z.
    Abstract: Hundreds of eponyms are used within the field of immunology—Petri dish, Crohn’s disease, Bence Jones protein, Kupffer cells, Freund's adjuvant, Ouchterlony immunodiffusion, to name just a few—but most of us don't know much about the individuals who gave their names to these terms. Where were they born and educated, what other accomplishments are they credited with, why has history chosen to remember them, or not? This book presents the first comprehensive collection of immunologic eponyms, and through them tells the story of this fascinating field, from its earliest beginnings to present day. Organized by surname and meticulously cross-referenced and indexed, this book offers historical anecdotes and little-known facts which scientists, clinicians, students, and general readers will find captivating and memorable. A one-of-a-kind introduction to immunology that serves as both a history lesson and current reference on the diseases, treatments, and individuals who have been crucial to this field.
    Type of Medium: Online Resource
    Pages: XXVIII, 405 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031145292
    DDC: 571.96
    Language: English
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  • 2
    Keywords: Medicine Research. ; Biology Research. ; Cardiovascular system. ; Physiology. ; Cardiology. ; Clinical biochemistry. ; Biomedical Research. ; Cardiovascular Physiology. ; Cardiology. ; Medical Biochemistry.
    Description / Table of Contents: Past, present and future perspectives of renin angiotensin system -- Biochemical pathways of renin angiotensin system -- Structure-function relationships of angiotensin II receptors -- Signal transduction mechanism of angiotensin II -- Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection -- Angiotensin II and the pathogenesis of hypertension -- Signaling transduction of angiotensin II in hypertension -- Role of angiotensin II type 1 receptors in vascular remodeling in hypertension -- Molecular and cellular mechanisms of renin-angiotensin system in hypertension -- Tissue renin-angiotensin system and risks in hypertension -- Oxidative stress and angiotensin II-induced hypertension -- Angiotensin II: inflammatory system disorder and hypertension -- Therapeutic approaches for angiotensin receptor blockers in hypertension -- Renin-angiotensin systems: A pivotal role in the development of atherosclerosis -- Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis -- Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability -- Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis -- The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation -- Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis -- Effects of angiotensin-converting enzyme and receptors in atherosclerosis -- Effects of angiotensin II on cardiac arrhythmia and signal transduction -- Angiotensin II induced oxidative stress contribute to ventricular arrhythmias -- Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias -- ACE inhibitor and ventricular arrhythmia in ischemic heart disease -- The renin-angiotensin system modulators and cardiac arrhythmias -- Angiotensin receptor blockers in the treatment of arrhythmias -- Angiotensin II induced cardiac hypertrophy and heart failure -- Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure -- Renin-angiotensin system: Molecular and cellular mechanisms in heart failure -- Role of angiotensin II receptor mRNA expression in heart failure -- Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure -- Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure -- Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure -- Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update -- Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure.
    Abstract: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
    Type of Medium: Online Resource
    Pages: XVIII, 452 p. 71 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031149528
    Series Statement: Advances in Biochemistry in Health and Disease, 24
    DDC: 610.72
    Language: English
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  • 3
    Keywords: Virology. ; Medicine Research. ; Biology Research. ; Life sciences. ; Virology. ; Biomedical Research. ; Life Sciences.
    Description / Table of Contents: 1. The Quest for Excellence and the Challenge of Gender Equality in Arbovirology: A Celebration of Women’s Contributions to the Field -- 2. Serendipity and Arboviruses -- 3. The Tapestry of Life: Weaving an Arbovirologist -- 4. Arbovirus and Viral Hemorrhagic Fevers Research Inception in Central and West Africa -- 5. From Bwamba to the Present: The Changing Forest of Arbovirology -- 6. Fighting Dengue, Chikungunya and Japanese Encephalitis -- 7. Chronicles of Hantaviruses: Foundations of Epidemiology and Ecology -- 8. Yellow Fever and Other Viruses in West Africa -- 9. The “Golden Age” of Arbovirology, 1950-1969 -- 10. Twenty-Seven Years of Field Studies on Dengue and Aedes Aegypti in Latin America -- 11. 50 Years of Medical Entomology: Miscellaneous Interesting Findings -- 12. Remembrances of Virology Past -- 13. An Overview of Arbovirology in São Paulo State, Southeastern Brazil: Highlighting the Virus Research Center in Ribeirão Preto City -- 14. An Unplanned Career in Arbovirology.
    Abstract: These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.
    Type of Medium: Online Resource
    Pages: XX, 542 p. 258 illus., 200 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031219993
    DDC: 579.2
    Language: English
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  • 4
    Keywords: Medicine Research. ; Biology Research. ; Medical education. ; Anatomy. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Medical Education. ; Anatomy. ; Virtual and Augmented Reality.
    Description / Table of Contents: Chapter 1. Pandemic-Era Digital Education: Insights from an Undergraduate Medical Programme -- Chapter 2. Use of Lt Systems in Large Class Lab Delivery -- Chapter 3. COVID-19 Adaptations for Biomedical Teaching and Assessment Within the Undergraduate Dental Curriculum -- Chapter 4. One Size Does Not Fit All in Remote Anatomy Teaching -- Chapter 5. From Lecture Halls to Zoom Links: How Can Educational Theory Help Us to Deliver Effective and Engaging Teaching in an Online Environment? -- Chapter 6. Collaborative, Two-Directional Live Streaming to Deliver Hands-on Dissection Experience during the COVID-19 Lockdown -- Chapter 7. Livestreaming Can Augment the Observation of Veterinary Post-mortem Examinations -- Chapter 8. Virtual Reality for Anatomy and Surgical Teaching -- Chapter 9. Can Synchronous Online Near-Peer Teaching Offer the Same Benefits as the Face-to-Face Version When Used in Clinical Neuroanatomy Education? -- Chapter 10. COVID-19 Adaptations with Virtual Microscopy -- Chapter 11. The Challenges of Visualisation During Delivery and Assessment of Clinical Teaching Under COVID-19: A Reflective Account of Problem Solving -- Chapter 12. Not for Room 101.
    Abstract: This book focuses on the challenges to biomedical education posed by the lockdowns and restrictions to on campus teaching brought about by the COVID-19 pandemic and highlights the tools and digital visualization technologies that have been successfully developed and used for remote teaching. Biomedical education for science, medical, dental and allied health professionals relies on teaching visual and tactile knowledge using practice-based approaches. This has been delivered for decades via on-campus lectures, workshops and laboratories, teaching practical skills as well as fundamental knowledge and understanding. However, the arrival of the COVID-19 pandemic meant that education across the globe had to pivot very quickly to be able to deliver these skills and knowledge in a predominantly online environment. This brought with it many challenges, as Higher Education staff, had to adapt to deliver these visual subjects remotely. This book addresses the challenges and solutions faced by Higher Education staff in teaching visual content in distance education. Chapters include literature reviews, original research, and pedagogical reflections for a wide range of biomedical subjects, degrees such as medicine, dentistry and veterinary sciences with examples from undergraduate and postgraduate settings. The goal of the book is to provide a compendium of expertise based on evidence gathered during the COVID-19 pandemic, as well as reflections on the challenges and lessons learned from this dramatic shift in teaching. It also presents new examples of best practices that have emerged from this experience to ensure that they are not lost as we return to on-campus learning in a new era of biomedical teaching. This book will be of interest to anyone looking for a helpful reference point when designing online or blended teaching for visual practice-based subjects.
    Type of Medium: Online Resource
    Pages: X, 228 p. 56 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031171352
    Series Statement: Advances in Experimental Medicine and Biology, 1397
    DDC: 610.72
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Medical sciences. ; Drug development. ; Medicine Research. ; Biology Research. ; Pharmaceutical chemistry. ; Biometry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Biomedical Research. ; Pharmaceutics. ; Biostatistics. ; Medical Toxicology.
    Description / Table of Contents: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.
    Abstract: This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.
    Type of Medium: Online Resource
    Pages: XII, 111 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031287602
    DDC: 615
    Language: English
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  • 6
    Keywords: Bioethics. ; Medicine Research. ; Biology Research. ; Biomedical engineering. ; Medical sciences. ; Drug development. ; Clinical medicine Research. ; Environment. ; Bioethics. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Preclinical Research. ; Clinical Research. ; Environmental Sciences.
    Description / Table of Contents: Foreword - Peter Singer -- Introduction: Biomedical Research in One World: Current and Future Challenges -- Part I - Biomedical Research -- Section One - Genetic and Cell Research -- Chap 1: Learning from Icarus: The Impact of CRISPR on Gene Editing Ethics -- Chap 2: Bioethical Decision Making and Genome Editing -- Chap 3: Therapeutic Genome Editing -- Chap 4: Bioethical Decision-Making about Somatic Cell Genome Editing: Sickle-Cell Disease as a Case Study -- Chap 5: Gene Therapy and Germline Cells Research -- Chap 6: Bioethical Quandaries in Preimplantation Genetic Diagnosis -- Chap 7: Rare Disease Research -- Chap 8: Limits of Debate: Governance of Human Embryo Research and the Making of the Fourteen-Day Rule -- Chap 9 Human/Non-Human Chimeras -- Chap 10: Human Cloning: Recent Advances and Bioethical Issues -- Section Two - Enhancement Research -- Chap 11: The Evolutionary Optimality Challenge -- Chap 12: Mood Enhancement -- Chap 13: Superior Sport Performance: Ethical and Legal Issues -- Chap 14: Arguments over Life Extension in Contemporary Bioethics -- Section Three - Research with Human Biological Samples and Health Data -- Chap 15: Research with Human Biological Samples. Systematization of the Phases and Affected Rights -- Chap 16: Biobanks for Biomedical Research: Evolution and Future -- Chap 17: Biobanking in Global Health & Research -- Chap 18: Ethical and Legal Considerations in Genomic Data Sharing: Evolution of the Discourse and the Road Ahead -- Section Four - Biomedical Challenges in Research -- Chap 19: Human Challenge Trials in Pandemics: Risks and Benefits -- Chap 20: Ethical Considerations for Vaccine Research -- Chap 21: Global Health Partnerships and Emerging Infectious Disease -- Chap 22: Precision Medicine -- Chap 23: The Development, Implementation, and Oversight of Artificial -- Intelligence in Health Care: Legal and Ethical Issues -- Part II - Animals, Food and Environment -- Section One - Using Animals in Scientific Research -- Chap 24: The Use of Animals in Basic Biological Research -- Chap 25: The Use of Animals in the Study of Human Disease: Key Roles of General Ethical Principles -- Chap 26: Ethical Issues Concerning Genetically Modified Animals for the Study of Human Diseases -- Chap 27: Of Mice-Rats and Pig-Men: Ethical Issues in the Development of Human/Nonhuman Chimeras -- Chap 28: Animals in Research in Pharmaceutical Industry -- Chap 29: Animal Use in Toxicity Studies -- Chap 30: Ethical Issues from the Use of Animals in the Cosmetics and Fashion Industries -- Chap 31: Is it Time to Phase Out the Use of all Nonhuman Primates in Invasive Research? -- Chap 32: Growing Human Organs Inside Animals -- Chap 33: Animal Cloning -- Section Two - Decision Making and Alternatives to Animal Use in Research -- Chap 34: Replacement, Reduction and Refinement -- Chap 35: Integrating Human and Nonhuman Research Ethics -- Chap 36: Regulation of Animal Research -- Section Three - GMOs for Global Challenges -- Chap 37: Ethical Issues in Genetically Modified Foods: From Transgenesis to CRISPR-Cas9 Genome Editing Technology -- Chap 38: GMOs and Human and Environmental Safety -- Chap 39: GMOs and Sustainable Agriculture.
    Abstract: The Handbook of Bioethical Decisions is aimed at addressing and analyzing the most important ethical concerns and moral quandaries arisen in biomedical and scientific research. As such, it identifies and problematizes on a comprehensive range of ethical issues researchers must deal with in different critical contexts. Thus, the Handbook, Vol. I, may be helpful for them to make decisions and deliberate in complex practical scenarios. In this fashion, the volume reunites different points of view to give readers room enough to get a better knowledge and take their own position on pressing bioethical issues of the day. Consequently, this work seeks to engender dense ethical epistemology scientists can count on when conducting latest generation biomedical research. By bringing together an impressive array of contributions on the most important elements and categories for “at the bench” bioethical decisions as well as offering chapters by some of the most world renowned and prominent experts in bioethics, the Handbook, Vol. I, is a paradigmatic text in its area and a valuable resource for courses on bioethics, and biomedical research, as well as courses that discuss ethics and the biosciences at different professional levels, biomedical industry, pharmacological companies and the public sphere in general. .
    Type of Medium: Online Resource
    Pages: XX, 778 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031294518
    Series Statement: Collaborative Bioethics, 2
    DDC: 174.2
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Aging. ; Medicine Research. ; Biology Research. ; Public health. ; Biotechnology. ; Psychiatry. ; Ageing. ; Biomedical Research. ; Public Health. ; Chemical Bioengineering. ; Psychiatry.
    Description / Table of Contents: Senescence opposed to longevity -- Genetics, the language of Proteomics -- Plants Uncover Senescence Animals Way Off Humans -- Rejuvenation stops Senescence -- Overlap of Senescence with Disease -- Mosaic Restricted to the Individuum -- Remaining Time until Death -- Laboratory Checkups -- eroprotectors.
    Abstract: This book is about lifelong ageing of humans. The basic biochemical and genetic mechanisms remain ill known, and differ among individuals. The book starts out to explore the plant and animal kingdoms to answer questions human ageing needs for understanding. First, we come to scrutinize time running out and what ‘normal’ means with impacts on the genome and on protein half- lives and function. Ageing goes beyond biochemical skid treated by geroprotector drugs, including biosimilars; albeit early diagnosis with standard medical laboratory assays, here addressed, sheds light with focus on basic research. Modern tools, including machine learning, and DNA technology, e.g. genomics, have already provided for unanticipated insights. The chapters then turn around senescence of the entire organism based on variable ageing of single organs embedded in neuronal networks . Psychological stress factors, dementia opposed to vigilance, and distinction of ageing from overt disease are contrasting in humans and are opposed in the book. Senescence, seen as a one way track may be reverted into rejuvenation, made possible by insights into immunosenescence and genomic approaches. Risk management in health insurance finds important clues in this book. The topics addressed between the book covers help to understand the trend to the ever- prolonging life expectancy beyond the centenarian age group; nursing care takers and pharmaceutical industry are invited to understand what’ is going on in senior people to make their geriatric population remain fit or become frail.
    Type of Medium: Online Resource
    Pages: XXIII, 132 p. 38 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031322761
    DDC: 571.878
    Language: English
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  • 8
    Keywords: Bioethics. ; Medicine Research. ; Biology Research. ; Science Moral and ethical aspects. ; Normativity (Ethics). ; Bioethics. ; Biomedical Research. ; Science Ethics. ; Normative Ethics.
    Description / Table of Contents: Foreword: On Handbooks -- Introduction -- Scientific Integrity and Institutional Ethics: Challenges and Perspectives -- Part I - Research Ethics -- Section One - Scientific Integrity and Research Misconduct -- Chap 1: Data Alteration -- Chap 2: Research Misconduct and Questionable Research Practices -- Chap 3: Ethics of Authorship -- Chap 4: Dissemination of Research Results -- Chap 5: Conflicts of Interest in Research -- Chap 6: A Priori Publication Agreements to Improve Adherence to Ethics in Research Publications -- Section Two - Conducting Ethical Research -- Chap 7: Freedom of Scientific Research and Primacy of Human Being: Practical and Epistemological Tensions -- Chap 8: Exploitation in Biomedical Research -- Chap 9: Selection of Research Subjects: Methodological and Ethical Issues -- Chap 10: Confidentiality and Privacy in Digital Clinical Trials -- Chap 11: Dematerialization and Intellectual Property in the Biosciences -- Part II - Institutional Ethics and Bioethics Committees -- Section One - Institutional Ethics -- Chap 12: Historical Development of Institutional Ethics and Bioethics -- Chap 13: Principles of Institutional Ethics -- Chap 14: Institutional Review Boards (IRB): US Perspectives -- Chap 15: Decision Making within Institutions -- Chap 16: Scientific Advances, Ethical Oversight and Legal Institutionality -- Section Two - Ethics and Bioethics Committees -- Chap 17: Members and Structure of Institutional Bioethics Committees -- Chap 18: Foundations of Bioethical Decision-Making in Bioethics and Biolaw -- Chap 19: Just Doing Bioethics': Policy, Principle, and Process -- Chap 20: Ethics Education and Institutional Ethics Committees -- Chap 21: Role of Ethics Committees in Emergency Use of Unproven Interventions Outside Research -- Chap 22: The Ethics of Resource Allocation in Pandemics: A Bayesian Model -- Section Three - Bioethical Issues in Institutional Ethics -- Chap 23: Scientific Knowledge and Social Responsibility -- Chap 24: Conscientious Objection -- Chap 25: Institutional Liability in Research -- Chap 26: Research Assessments Should Recognize Responsible Research Practices. Narrative Review of a Lively Debate and Promising Developments -- Chap 27: Coercion in Mental Health Treatment.
    Abstract: The Handbook of Bioethical Decisions Volume II addresses and analyzes the most important ethical concerns and moral quandaries related to scientific integrity and institutional ethics. It counts on two parts, Part One: Research Ethics, which addresses issues related to Scientific Integrity, Research Misconduct and Conducting Ethical Research, and Part Two: Institutional Ethics and Bioethics Committees, which explores Institutional Ethics issues, Ethics and Bioethics Committees’ roles and scopes, and Bioethical Issues in Institutional Ethics. Consequently, the Handbook, Vol. II, offers a remarkable collection of works by outstanding international experts on institutional and research ethics, in order for bioethics practitioners to obtain better elements to address key issues related to integrity in research as well as to decision-making processes. In this fashion, this volume is a valuable resource for professionals working on different bioethical and biomedical fields, such as, ethics and bioethics committees, health care institutions, biomedical and pharmacological companies, and academic settings, among others. Chapter 26 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVIII, 487 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031294556
    Series Statement: Collaborative Bioethics, 3
    DDC: 174.2
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bacteria. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Immunology. ; Food Safety measures. ; Therapeutics. ; Bacteria. ; Medical Microbiology. ; Biomedical Research. ; Immunology. ; Food Safety. ; Therapeutics.
    Description / Table of Contents: Chapter 1. WHO Critical Priority Escherichia coli in Latin America: A One Health Challenge for a PostPandemic World -- Chapter 2. Recent progress on enterotoxigenic E. coli (ETEC) and antibiotic resistance in pathogenic E. coli -- Chapter 3. New concepts on domestic and wild reservoirs, and transmission of E. coli and its environment -- Chapter 4. New molecular mechanisms of virulence and pathogenesis in E. coli.-Chapter 5. Bovine reservoir of STEC and EPEC: advances and new contributions -- Chapter 6. Phages and Escherichia coli -- Chapter 7. Insights into animal carriage and pathogen surveillance in Latin America: the case of STEC and APEC -- Chapter 8. Shiga Toxin and its effect on the Central Nervous System -- Chapter 9. Relevance of Escherichia coli in fresh produce safety -- Chapter 10. Quantitative Microbial Risk Assessment of Hemolytic Uremic Syndrome due to Beef Consumption: Impact of Interventions to Reduce the Presence of Shiga Toxin-Producing Escherichia coli -- Chapter 11. An Updated Overview on the Resistance and Virulence of UPEC -- Chapter 12. Interactions of pathogenic Escherichia coli with gut microbiota -- Chapter 13. Emergence of Hybrid Escherichia coli Strains -- Chapter 14. Genomic analysis of pathogenic E. coli strains in Latin America -- Chapter 15. Therapeutic options for diarrheagenic Escherichia coli.
    Abstract: Latin America has been at the forefront in combating infections caused by Escherichia coli strains in humans, animals, and the environment. The continuous emergence and evolution of pathogenic E. coli strains associated with human and animal infections have demonstrated that (i) groups of related pathogenic E. coli are responsible for most infections caused by this bacterial species; (ii) diverse virulence phenotypes expressed during infection defined each one of these pathogroups; (iii) the geographical distribution of pathogroups in Latin America and the evolution of new isolates was defined by the dominant pathogroup and presence of distinct virulence strains; (iv) acquisition of mobile elements or accumulation of point mutations accelerate the development of antibiotic resistance in some of these strains. The Latin American Coalition for Escherichia coli Research (LACER), a multidisciplinary network of over seventy research groups in eleven Latin American countries and the USA, was established in 2009 to apply One Health principles in defining and combating this pathogen. The previous edition of this text, Escherichia coli in the Americas was the culmination of the investigators' wisdom about E. coli, from its role as a commensal bacterium to its characteristics as a pathogen. This new edition introduces recent advances and contextualizes all aspects of E. coli in a One Health perspective, from the environment, to animals, to humans. It addresses E. coli interactions with host microbiota, CNS, and phages, and includes cutting edge insights on hybrid strains, molecular mechanisms of virulence and pathogenesis, domestic and wild reservoirs, disease surveillance in Latin America, food safety, and new therapies. Crucially, it also presents translations and analysis of key reports on Escherichia coli published in Spanish and Portuguese. This book serves as a critical resource for scientists in industry and academia, clinicians managing associated infections, and trainees and students studying basic and clinical aspects of E. coli pathogenesis. .
    Type of Medium: Online Resource
    Pages: XX, 363 p. 19 illus., 17 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031298820
    DDC: 579.3
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Bioinformatics. ; Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Bioinformatics.
    Description / Table of Contents: Brain Tissue Oxygen and BOLD fMRI Under Different Levels Of Neuronal Activity -- Cerebral Microcirculation and Oxygenation Modulation by Transcranial Alternating Current Stimulation in Awake and Anesthetized Mice -- The Effect of Hypercapnia on Cortical Metabolic Rate and Mitochondrial Redox Status -- Relationship Between Left-Right Dominancy of Prefrontal Cortex Activity and Heart Rate During Rest and Task Periods: An fNIRS Study -- Relationship Between Cognitive Function, Oral Conditions and Systemic Metabolic Function in the Elderly -- Pro-survival Phenotype of HIF-1α: Neuroprotection through Inflammatory Mechanisms -- Infradian Rhythms in Cerebrovascular Oxygenation and Blood Volume in Humans at Rest: A 5-year Study -- Mechanisms of Photostimulation of Brain’s Waste Disposal System: the Role of Singlet Oxygen -- Changes of Arterial and Venous Cerebral Blood Flow Correlation in Moderate-to-Severe Traumatic Brain Injury: A CT Perfusion Study -- Cerebral Net Water Uptake in Posttraumatic Cerebral Ischemia -- Brainstem Damage Underlies Changes in Hypoxic Ventilatory Response following Cardiac Arrest and Resuscitation in Rats -- Differences Between Good, Moderate and Poor Performers of a Verbal Fluency Task under Blue Light Exposure: An SPA-fNIRS Study -- Sex-specific and Dose-dependent Effects of Drag-Reducing Polymers on Microcirculation and Tissue Oxygenation in Rats after Traumatic Brain Injury -- Accuracy of Tissue Oxygen Saturation Measurements of a Textile-based NIRS Sensor -- Understanding the Role of Caveolae in Oxygen Buffering: The Effect of Membrane Curvature -- The Significance of Lipids for the Absorption and Release of Oxygen in Biological Organisms -- How Skin Color Depends on Tissue Oxygenation -- Tissue Concentration Analysis of Sulfur, Calcium and Oxygen in novel Skin Primo Nodes After Acupuncture -- Primo Vessels Inside Lymphatic Vessels are Absent in an ALS Mouse Model -- The Impact of Heterogeneous Cell Density in Hypoxic Tumors Treated with Radiotherapy -- A Critical Analysis of Possible Mechanisms for the Oxygen Effect in Radiation Therapy with FLASH -- Hyperhydration of Cancers: A Characteristic Biophysical Trait Strongly Increasing O2, CO2, Glucose and Lactate Diffusivities, and Improving Thermophysical Properties of Solid Malignancies -- No Difference in Muscle Basal Oxygenation in a Bedridden Population pre and Post Rehabilitation -- Relationship between Muscle Deoxygenation and Cardiac Output in Subjects without Attenuation of Deoxygenation Hemoglobin Concentration near the end of Ramp Cycling Exercise: A Longitudinal Study -- Image Reconstruction Using Deep Learning for Near-Infrared Optical Tomography: Generalization Assessment -- Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy -- Time Domain Near-Infrared Optical Tomography Utilizing Full Temporal Data: A Simulation Study -- BIAN: A Multilayer Microfluidic-Based Tissue-Mimicking Phantom for Near-Infrared Imaging -- Do Vascular and Extracellular Measurements Consistently Reflect Intracellular pO2? Observation of Tissue Oxygenation Changes using Remote Photoplesysmography with a Smartphone -- Neurovascular, Metabolic, and Glymphatic Dynamics of the Brain Measured with fNIRS -- Imaging Cerebral Blood Vessels Using Near-Infrared Optical Tomography: A Simulation Study -- Reduced Cerebrovascular Oxygenation in Individuals with Post-Acute COVID-19 Syndrome (PACS) (“Long COVID”) -- Insufficient Oxygen Supplementation During Cardiopulmonary Resuscitation Leads to Unfavorable Biological Response While Hyperoxygenation Contributes to Metabolic Compensation -- Block of the Angiotensin Pathways Affects Flow-Volume Spirometry in Patients With SARS-CoV-2 Infection -- A Prospective Observational Pilot Study on the Effects of the Activity-based Stress Release Program on the Mental State and Autonomic Nervous System in Psychiatric patients. .
    Abstract: This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 49th annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2022). Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource.
    Type of Medium: Online Resource
    Pages: XIX, 240 p. 91 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031420030
    Series Statement: Advances in Experimental Medicine and Biology, 1438
    DDC: 571.6
    Language: English
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  • 11
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Neurology . ; Neurosciences. ; Nervous system Diseases. ; Biomedical Research. ; Neurology. ; Neuroscience. ; Neurological Disorders.
    Description / Table of Contents: PART I: Fundamental Aspects -- Chapter 1. Definition of Tremor -- Chapter 2. Membrane Mechanisms of Tremor -- Chapter 3 Advances in the Genetics of Human Tremor -- Chapter 4. Two origins of tremors related to the Guillain-Mollaret triangle: the forward model-related tremor and the inferior olive oscillation-related tremor -- PART II:Tremor in Clinical Practice -- Chapter 5. Physiologic Tremor -- Chapter 6. Rest Tremor -- Chapter 7. Postural Tremors -- Chapter 8. Isometric Tremor -- Chapter 9. Essential Tremor and Other Forms of Kinetic Tremor -- Chapter 10. Cerebellar lesions and tremor -- Chapter 11. Orthostatic Tremor -- Chapter 12. Posttraumatic Tremor and Other Posttraumatic Movement Disorders -- Chapter 13 Tremor in Childhood -- Chapter 14. Metabolic Causes of Tremor -- Chapter 15. Drug-Induced Tremor -- Chapter 16. Tremor: The Clinical Approach to Reach the Diagnosis -- PART III: Assessment of tremor -- Chapter 17. Signal Processing -- Chapter 18. Diffusion imaging in Tremor -- Chapter 19. The role of the noradrenergic system in tremor pathogenesis -- Chapter 20. Metabolic Networks in Parkinson’s Disease -- PART IV: Therapies -- Chapter 21. Deep brain stimulation for tremor -- Chapter 22 Mechatronic Devices for Upper Limb Tremor.
    Abstract: Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.
    Type of Medium: Online Resource
    Pages: X, 558 p. 86 illus., 59 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031261282
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 610.72
    Language: English
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  • 12
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cardiovascular system. ; Physiology. ; Cardiology. ; Medicine Research. ; Biology Research. ; Medical sciences. ; Health. ; Sex. ; Cardiovascular Physiology. ; Cardiology. ; Biomedical Research. ; Health Sciences. ; Gender and Health.
    Description / Table of Contents: Attenuation of Bnip3 Mediated Doxorubicin-Induced Cell Death in Cardiac Myocytes -- Sex Dependent Regulation of Circadian Rhythms in Health and Disease -- Circadian Pharmacological Approach to Treat Myocardial Infarct -- GPER Function as a Determinant of the Progression of Atherosclerotic Disease in Women -- Novel Therapeutic Approach to Treat Cardiac-Rheumatology in Females -- Correlation between Sex, Immigration Status, Ethnicity, and Long-term Outcomes of Ischemic Stroke -- Risk Assessment and Predictive Modelling for The Heart-Brain Interface in Women -- Insomnia Interventions for Female Cardiac Patients -- Aortic Stenosis Progression, Cardiac Damage, and Survival: Comparison Between Men and Women -- Treatment and Management of Valvular Heart Disease and Cost-Effectiveness Analysis -- Association of Mortality and Acute Aortic Events with Ascending Aortic Aneurysm -- Improving Diagnosis and Treatment for Patients Who Suffer Spontaneous Coronary Artery Dissection (SCAD) -- Preeclampsia and Future Cardiovascular Health -- Cardiovascular Disease in Women with a History of Pregnancy Complications -- Hormone Replacement Treatment for Cardiovascular Disease -- Cardiovascular Mortality Following Early-Stage Breast Cancer -- Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease in Women -- Sex Differences in Cardiac Rehabilitation Enrollment -- Promoting Exercise and Physical Activity in Female Patients with Heart Disease -- Sex and Gender Differences in the Diagnosis, Treatment, and Outcomes of Coronary Artery Disease -- Sex Differences in Arterial Aging and its Implications on Cardiovascular Diseases -- Impact of a Novel Community-Based Lifestyle Intervention Program on Type 2 Diabetes and Cardiovascular Risk -- Clinical Outcomes Related to Heart Failure and Pulmonary Hypertension -- Examination of Health-Related Quality of Life in Women with Coronary Artery Disease -- The Risks and Benefits of Implantable Cardioverter-Defibrillator Generator Replacement -- The Effects and Roles of Estrogen in Managing Hypertension in Menopausal Women -- The Effects of Menopausal Hormone Therapy on the Vascular System -- Influence of Sex Differences in Non-Obstructive Coronary Artery Disease -- Diet1 and Resistance to High Cholesterol Levels and Cardiovascular Disease -- Interventions to Improve Clinical Outcomes Following Hospitalization for Heart Failure -- Sex-Dependent Cardioprotective Effects of the Phytoestrogen Resveratrol -- Blood Pressure Across a Woman's Life Cycle -- Women’s Fitness Levels and Heart Rate Response to Exercise -- Supervised Exercise Therapy Through Cardiac Rehabilitation following Peripheral Arterial Disease -- Sex Differences in ANT2-Mediated ATP Import into Mitochondria for Protection Against Hypoxia Lethal Injury.
    Abstract: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in women and men worldwide and represents a major financial burden to world health care systems. Importantly, CVD has eclipsed cancer as the leading cause of death for women globally. Through advancements in research and clinical testing, the symptoms and risk factors for CVD have been well established for men, but not for women. Consequently, there is an immediate need for new innovative research that will bridge this gap and allow for improved early diagnosis and treatment of CVD in women. This book will serve as a guide for health care providers to better understand the physiological, biochemical, and genetic differences in heart disease in women with the goal of providing improved education, awareness and treatment of cardiovascular disease in women. The book will cover topics such as: sex dependent clinical outcomes of cardiovascular disease, cardiac protection by estrogen, cardiac health during menopause, cardiac rehabilitation programs, fitness and exercise, cardio-oncology, shift work and the CVD risk, and pregnancy related CVD.
    Type of Medium: Online Resource
    Pages: VII, 446 p. 56 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031399282
    Series Statement: Advances in Biochemistry in Health and Disease, 26
    DDC: 573.1
    Language: English
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  • 13
    Keywords: Medicine Research. ; Biology Research. ; Vocational guidance. ; Career education. ; School management and organization. ; School administration. ; Biomedical Research. ; Career Counseling. ; Career Skills. ; Organization and Leadership.
    Description / Table of Contents: Part 1: Setting the scene -- Chapter 1: Life after Academia: Launching your Pharma/Biotech Career -- Chapter 2: Competences for Pharmacists -- Chapter 3: Job and Career Opportunities in the Pharmaceutical Industry: An Overview -- Part 2: Opportunities along the drug/product life cycle -- Chapter 4: Career Opportunities in Toxicology -- Chapter 5: Job Possibilities in Clinical Research -- Chapter 6: How to Get and Develop a Career in a Market Access Role in the Medical Devices Industry -- Chapter 7: Job Opportunities in Pharmaceutical Marketing -- Chapter 8: Working in Medical Affairs and Clinical Operations: Life-Changing Careers -- Chapter 9: The Role of Medical Science Liaison -- Chapter 10: Career Development for Physicians in the Biopharmaceutical Industry -- Part 3: Opportunities in Supportive Functions -- Chapter 11: Job and Career Opportunities in Regulatory Affairs/Science -- Chapter 12: Job Opportunities in Clinical Research Quality Assurance -- Chapter 13: Job Opportunities in Quality Assurance Related to Manufacturing of Medicinal Products -- Part 4: Other Opportunities in the Pharmaceutical and Biomedical Sector -- Chapter 14: Careers Perspective in a Science and Technology Park -- Chapter 15: To be or not to be: Entrepreneurship and Enterprise Creation as a Way to Innovate in Life Sciences -- Chapter 16: How to Become a Successful Hospital and Community Pharmacist -- Part 5: Practical tips and tricks -- Chapter 17: A Successful Career in the Life Sciences Industry: How to Write your Strongest Resumé and Ace that Interview -- Chapter 18: Skill Building for Career Advancement: Public Speaking and Networking -- Chapter 19: Training Opportunities for a Career in the Pharmaceutical and Biomedical Industry/Sector.
    Abstract: Written by dedicated and active professionals from different areas of the pharmaceutical, biomedical, and medtech sectors, this book provides information on job and career opportunities in various life sciences industries. It also contains useful tips to launch your own startup. The pharmaceutical, biomedical and medical technology sectors offer a wide range of employment opportunities to talented and motivated young graduates. However, many of these employment prospects are not well known to early career scientists, who concentrate primarily on the scientific and academic content of their fields of interest. The book is divided into five parts: Part 1 provides an academic perspective that focuses on the specific preparation required in the final years of study to embark on a successful career in the pharmaceutical and biomedical industries. In Part 2, industry experts discuss employment possibilities all along the drug or product life cycle, from discovery research and development to commercialisation. Part 3 follows, highlighting opportunities in support functions such as regulatory affairs or quality assurance. Part 4 focuses on additional opportunities in the wider biomedical sector, while Part 5 contains practical tips and training opportunities for entering the pharmaceutical and biomedical industries. In the epilogue, the authors reflect on this fascinating field and its career prospects. The book offers a multidisciplinary perspective on career opportunities in the pharmaceutical and biomedical industry to a wide range of students and young life scientists. .
    Type of Medium: Online Resource
    Pages: XXI, 328 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031149115
    DDC: 610.72
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Clinical medicine Research. ; Epidemiology. ; Diseases Causes and theories of causation. ; Biomedical Research. ; Clinical Research. ; Epidemiology. ; Pathogenesis.
    Description / Table of Contents: 1. Introduction on Tuberculosis: Integrated Studies for a Complex Disease -- 2. Global Tuberculosis Epidemiology -- 3. Heterogeneity in Tuberculosis -- 4. The Unequivocal Relationship between Tuberculosis and Tobacco: Integration of Two Maladies -- 5. Relationship between Pre-existing Cancer and Tuberculosis -- 6. Laboratory Diagnosis of Tuberculosis -- 7. The Role of Diagnostic Microdevices in the Fight Against Tuberculosis -- 8. Immunodiagnostics of Tuberculosis: Recent Discoveries -- 9. Role of Bronchoscopy in Diagnostics and Treatment of Tuberculosis -- 10. Diagnosis of Childhood Tuberculosis in Low- and Middle-income Countries -- 11. Pediatric Tuberculosis: Current Evidence for Laboratory Diagnosis -- 12. A Multidisciplinary Approach Towards Finding and Treating All Tuberculosis Patients -- 13. Chemotherapy for Drug-Susceptible Tuberculosis -- 14. The Pharmacokinetic and Pharmacodynamic Properties of Antitubercular Medications -- 15. Immune Approaches In Tuberculosis Treatment -- 16. Inhalation Therapy in Pulmonary Tuberculosis -- 17. Role of Micronutrients in Tuberculosis Management -- 18. Drug Resistance in Tuberculosis: Mechanisms, Diagnosis, New Responses, and the Need for An Integrated Approach -- 19. Resistance in Tuberculosis: Molecular Mechanisms and Modulation -- 20. Personalized Tuberculosis Care for Drug-Resistant Tuberculosis -- 21. Important Targets and Inhibitors of Mycobacterium Tuberculosis -- 22. P-type ATPases: A Relevant Component in Mycobacterium tuberculosis Viability -- 23. The Challenges of Antitubercular Drug Discovery -- 24. Exploring Decaprenylphosphoryl-β-D-ribose 2’-Epimerase 1 (DprE1): A Target for Anti-Tubercular Drugs -- 25. Energy Pathways in Mycobacterium Tuberculosis -- 26. Drug Discovery for Non-Tuberculous Mycobacteria: Recent Updates -- 27. Challenges for Contact Tracing and Tuberculosis Preventive Therapy Scale-up -- 28. Exploring Problematizations Underlying Tuberculosis Control Strategies: A Cross-Country Analysis of India and Kenya -- 29. Challenges in Prevention and Management of Tuberculosis -- 30. Tuberculosis in Contacts and Healthcare Workers -- 31. Tuberculosis Among People Who Use Drugs: Multilevel Considerations for Prevention, Diagnosis, and Treatment -- 32. Anti-Tumor Necrosis Factor-α Antagonists and Tuberculosis -- 33. Breast Tuberculosis -- 34. Central Nervous System Tuberculosis: Pathogenesis, Diagnosis, and Management -- 35. Pleural Tuberculosis -- 36. Ocular Tuberculosis -- 37. Ocular Tuberculosis: Biomarkers for Risk Stratification -- 38. Bone and Joint Tuberculosis -- 39. Abdominal Tuberculosis: Pathogenesis, Clinical Features, and Diagnosis -- 40. Bovine Tuberculosis at The Interface of Cattle, Wildlife, and Humans -- 41. Evolution and Molecular Characteristics of Mycobacterium Tuberculosis and Mycobacterium Bovis -- 42. Animal Tuberculosis: Gross Lesions and Anatomopathological Diagnosis -- 43. Estimation of Microbial Mutation Rates in Tuberculosis Research -- 44. The Role of Epigenetics in the Development of Anti-Tuberculosis Drug Resistance -- 45. Multiomics Integration of Tuberculosis Pathogenesis -- 46. Lung Microbiome in Tuberculosis -- 47. The Correlation of Microbiota and Host Epigenome in Tuberculosis -- 48. The Pathogenesis and Progression of Sarcoidosis from The Standpoint of Tuberculosis -- 49. Tuberculosis: A Historical and Global Bioethical Perspective -- 50. The Problem of Tuberculosis: Myths, Stigma, and Mimics -- 51. Tuberculosis: Integrated Studies for a Complex Disease 2050.
    Abstract: Tuberculosis have been documented since antiquity and the search of the microbes that cause this disease started more than three hundred years ago. Nevertheless, tuberculosis remains an important global health issue, with millions of people affected per year in addition to millions that remain undiagnosed and untreated. Patients with tuberculosis face the full range of recurrence, reinfection, and resistance due to diagnostic, prophylactic, and therapeutic procedures that are not as effective as they should be. In addition, variability in susceptibility to tuberculosis pose a complex problem with numerous interrelated variables. This volume is devoted to the understanding of Tuberculosis focusing on its heterogeneity, its transmission, manifestations, related conditions, diagnosis, treatments, drug resistance and prevention.
    Type of Medium: Online Resource
    Pages: XXIV, 1116 p. 363 illus., 239 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031159558
    Series Statement: Integrated Science, 11
    DDC: 610.72
    Language: English
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  • 15
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacy. ; Pharmaceutical chemistry. ; Pharmacology. ; Medicine Research. ; Biology Research. ; Pharmacy. ; Pharmaceutics. ; Pharmacology. ; Biomedical Research.
    Description / Table of Contents: Overview of Freeze Drying -- Characterization and Determination of Freeze Drying Properties of Frozen Formulations – Case Studies -- Beyond pH: Acid/base relationships in frozen and freeze-dried pharmaceuticals -- Concepts and Strategies in the Design of Formulation for Freeze Drying -- Formulation Design for Freeze Drying - Case studies of Stabilization of Proteins -- Challenges and Considerations in the Development of a High Protein Concentration Lyophilized Drug Product -- Freeze-drying of thermosensible pharmaceuticals with organic co-solvent + water formulations -- Primary container closure system selection for lyophilized drug products -- Vial Breakage During Lyophilization -- The Nucleation of Ice -- Stresses, Stabilization, and Recent Insights in Freezing of Biologics -- Lyophilization Process Understanding and Scale-up using ab initio Vial Heat Transfer Modeling -- Secondary drying: Challenges and Considerations -- Design and Process Considerations in Spray Freeze Drying -- LyoPRONTO: Deterministic and Probabilistic Modeling. Tutorial and Case Study -- Utilizing Solid-State NMR Spectroscopy to Assess Properties of Lyophilized Formulations -- Design of Moisture Studies for a Lyophilized Product -- Laser-Based Headspace Moisture Analysis for Rapid Nondestructive Moisture Determination of Lyophilized Products -- Application of PAT in Real-time Monitoring and Controlling of Lyophilization Process -- Process Analytical Technology (PAT) for Lyophilization Process Monitoring and End Point Detection -- Advances in Process Analytical Technology – A Small Scale Freeze-Dryer for Process Analysis, Optimization, and Transfer -- Overview of Heat and Mass Transfer Modeling in Lyophilization to Create Design Spaces and Improve Process Analytical Tool (PAT) Capability -- Application of QbD elements in the Development and Manufacturing of a Lyophilized product -- Characterization of Freeze Dryer -- Scale-up and Technology Transfer of a Lyophilization Process -- Lyophilization Validation: Process Design and Modeling -- Lyophilization Validation: Process Qualification and Continued Process Verification -- Homogeneity Assessment of Lyohilized Biological Drug Products During Process Performance Qualification -- Informed Manufacturing through the use of Big Data Analytics for Freeze Drying Process & Equipment -- Multivariate Analysis for Process Understanding, Continuous Process Verification and Condition Monitoring of Lyophilization Processes -- Lyophilized Drug Product Cake Appearance: What Is Acceptable?.
    Abstract: The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T cell engager ( BITES), Dual Variable Domain ( DVD), Chimeric Antigen Receptor - Modified Tcells (CART) that are currently being used as therapeutic agents for immunology and oncology disease conditions. In addition to other pharmaceuticals and biopharmaceuticals, all these novel formats are fragile with respect to their stability/structure under processing conditions meaning marginal stability in the liquid state and often require lyophilization to enhance their stability and shelf-life. This book contains chapters/topics that will describe every aspect of the lyophilization process and product development and manufacturing, starting from the overview of lyophilization process, equipment required, characterization of the material, design and development of the formulation and lyophilization process, various techniques for characterization of the product, scale-up/tech-transfer and validation. It also describes the application of CFD coupled with mathematical modeling in the lyophilization process and product development, scale-up, and manufacturing. Additionally, Principles and Practice of Lyophilization Process and Product Development contains an entire dedicated section on “Preservation of Biologicals” comprised of nine chapters written by experts and including case studies.
    Type of Medium: Online Resource
    Pages: XIII, 623 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031126345
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 59
    DDC: 615.1
    Language: English
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  • 16
    Keywords: Biotechnology. ; Biology Technique. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Biological Techniques. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. Management of Biobanks -- Chapter 2. Quality Management -- Chapter 3. Documentation and Records -- Chapter 4. Human Resources Management -- Chapter 5. Ethical and Legal Aspects -- Chapter 6. Supplies, Materials Management -- Chapter 7. Equipment -- Chapter 8. Traceability -- Chapter 9. Environmental and Staff Hygiene -- Chapter 10. Biobanking Processes and Quality Control -- Chapter 11. Deviations, Nonconforming Product/Data or Service -- Chapter 12. Audits -- Chapter 13. Improvement -- Chapter 14. Biobank Cooperation in the Scientific, Research and Development Area -- Chapter 15. Safety and Security.
    Abstract: This pioneering handbook serves as an essential tool for any biobanking entity to create, implement and continuously improve their Quality Management System (QMS). Written in a concise and highly readable manner all biobanking related QMS aspects, ranging from legal aspects to safety matters, are addressed according to the best knowledge in compliance with the dedicated Biobanks ISO standards. Following a practical approach by making use of FAQ and common practice sections this book guides the readers through this complex field in an easy-to understand way. The guidelines are convergent not only with ISO 20387:2018 Biotechnology - Biobanking - General requirements for biobanking but also with ISO 9001:2015, ISO 19011:2018, ISO 27000:2014, and ISO 27002:2013. Furthermore, they are compatible, among others with the recommendations of the Organization for Economic Cooperation and Development (OECD), IARC, and ISBER Best Practices. Aimed at both biobank employees and other stakeholders (e.g. public bodies, political bodies, hospitals, pharmaceutical industry, funders) at any level of experience the book serves as valuable source for self-education and teaching. The manual complies to the principles of responsibility, openness, and transparency and can be used by any biobanking unit regardless of the biological material the biobank operates with and independent of their associated biobank network. On behalf of a group of specialists and experts in the area of biobanking, regarding Quality Management Systems (QMS), Ethical, Legal and Societal Issues (ELSI) and IT solutions, the authors present with this book a significant achievement based on activities within the project, European Research Infrastructure BBMRI-ERIC „Quality Standards for Polish Biobanks” Handbook (QSPB).
    Type of Medium: Online Resource
    Pages: XVII, 152 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031125591
    DDC: 660.6
    Language: English
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  • 17
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Public health. ; Epidemiology. ; Medical policy. ; Medicine, Preventive. ; Health promotion. ; Biomedical Research. ; Public Health. ; Epidemiology. ; Health Policy. ; Health Promotion and Disease Prevention.
    Description / Table of Contents: Introduction on Integrated Science of Global Epidemics -- Emerging Viral Infections in Human Population -- One Health as An Integrated Approach: Perspectives from Public Services for Mitigation of Future Epidemics -- Multipronged Approach to Combat COVID-19: Lessons from Previous Pandemics for the Future -- Response to Disease Outbreaks in Africa: A Call to Build Resilient Health Systems -- Navigating Global Public Influenza Surveillance Systems for Reliable Forecasting -- Three Respiratory Syndrome Epidemics (SARS, MERS, COVID-19) in Two Decades: Clinical Epidemiological Considerations -- Epidemic in Complex Networks and Some Ideas About the Impact of Isolation Strategies in the Context of the COVID-19 Pandemic -- Optimal Control: Application and Applicability in Times of Pandemics -- Analysis of A COVID-19 Model Implementing SocialDistancing as An Optimal Control Strategy -- Impact of Policy Implementations on the Propagation of COVID-19 Before Vaccine -- Environmental Factors Associated with Global Pandemic Transmission and Morbidity -- Urbanization and the Epidemiology of Infectious Diseases: Towards the Social Framing of Global Responses -- Pandemics and Mass Casualties: Cornerstones of Management -- Social Marketing Contributions to Mitigate Global Epidemics -- The Significance of Super Intelligence of Artificial Intelligence Agencies in the Social Savageries of COVID-19: An Appraisal -- Integration of Sex and Gender Approaches in National Ethics Committees’ Mandate to Appraise COVID-19 Research Protocols: Lessons from West Africa -- Psychology, Law, Ethics, Telehealth, and the Global Pandemic -- Physical Inactivity, Sedentarism, and Low Fitness: A Worldwide Pandemic for Public Health -- The Global Epidemic of Diabesity: Are We Heading for An Unsustainable Future? -- Nutrition, Function, and Quality of Life in Older Adults Socially Isolated Due to the COVID-19 Pandemic: A Focus on Telehealth Interventions -- Africa’s Response to Pandemics -- Vaccine Hesitancy and Refusal: History, Causes, Mitigation Strategies -- Vaccine Compliance versus Trust in a Pandemic -- Child Development in A Crisis: A Pandemic -- HIV/AIDS Problems and Policies in Adolescent Population -- Addressing Needs of Foreign Schoolchildren to Combat a Global Epidemic of Dengue Virus Infection: Transnational and Trans-sectoral Initiatives -- Integrated Science of Global Epidemics 2050.
    Abstract: The “Integrated Science of Global Epidemics” is the new proposed volume of Integrated Science Book series, aiming to publish the results of the most updated ideas and reviews on Global Epidemics. The whole world is suffering from complex problems, border less problems and global solution should be developed. The Integrated Science of Global Epidemics aims to highlight the combination of different disciplines, including formal sciences, physical-chemical sciences and engineering, biological sciences, medical sciences, and social sciences, to deal with complex problems such as global epidemics. This contributed volume could be used as guidelines for the entire scientific community and policy makers to successfully face these global threats. Chapter 27 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 623 p. 170 illus., 144 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031177781
    Series Statement: Integrated Science, 14
    DDC: 610.72
    Language: English
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  • 18
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.
    Abstract: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
    Type of Medium: Online Resource
    Pages: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031162862
    DDC: 571.978
    Language: English
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  • 19
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Cytology. ; Medicine Research. ; Biology Research. ; Computational and Systems Biology. ; Cell Biology. ; Biomedical Research. ; Bioinformatics.
    Description / Table of Contents: Chapter 1: The Structure And Function Of Living Organisms -- Chapter 2: Energy In Biology – Demand And Use -- Chapter 3: Information – Its Role And Meaning In Organism -- Chapter 4: Regulation In Biological Systems -- Chapter 5: Interrelationship In Organized Biological Systems. .
    Abstract: This open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader aware of the unity of the laws of physics, chemistry and biology. The fully updated 2nd edition also contains information that has only become available as a result of the increase in knowledge in recent years. This includes information on tumorigenesis, where significant progress has been made due to the explosive development of genetic knowledge as well as bioengineering with a highly effective technique adopted from the solutions of the bacterial world, such as CRISPR/CAS. This richly illustrated book is essential for postgraduate students and scientists of the following disciplines: biology, biotechnology, medicine, bioinformatics, robotics and automation, biocybernetics, and biomedical engineering. It is also an exciting read for anyone interested in biology.
    Type of Medium: Online Resource
    Pages: XVII, 257 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031315572
    DDC: 570.285
    Language: English
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  • 20
    Keywords: Zoology. ; Plant diseases. ; Forestry. ; Geology. ; Zoology. ; Plant Pathology. ; Forestry. ; Geology.
    Description / Table of Contents: Section I: Introduction to Forest Entomology -- 1. Introduction to and the Importance of Insects -- 2. Form and Function -- 3. Forest Arthropod Biodiversity -- 4. Insect Ecology -- 5. Forest Insect Population Dynamics -- 6. Forest Insect -Natural Enemy Interactions -- 7. Forest Insect-Plant Interactions -- 8. Insects and Forest Succession. Section II: Categories of Insects that Damage Trees -- 9. Foliage Feeders -- 10. Bark Beetles -- 11. Ambrosia Beetles -- 12. Woodborers in Forest Stands -- 13. Sap-sucking Forest Pests -- 14. Gall Formers -- 15. Tip, Shoot, Root and Regeneration Pests -- 16. Insects of Reproductive Structures -- Section III: Management of Forest Insect Pests -- 17. IPM: the Forest Context -- 18. Spatial Dynamics of Forest Insects -- 19. Monitoring and Surveillance of Forest Insects -- 20. Silviculture -- Section IV: Future Prospects -- 21. Forest Health in the Anthropocene -- 22. Climate Change and Forest Insect Pests -- 23. Forest Insect Invasions and their Management.
    Abstract: This open access book will provide an introduction to forest entomology, the principles and techniques of forest insect pest management, the different forest insect guilds/feeding groups, and relevant forest insect pest management case studies. In addition to covering 30% of the earth, forest ecosystems provide numerous timber and non-timber products that affect our daily lives and recreational opportunities, habitat for diverse animal communities, watershed protection, play critical roles in the water cycle, and mitigate soil erosion and global warming. In addition to being the most abundant organisms in forest ecosystems, insects perform numerous functions in forests, many of which are beneficial and critical to forest health. Conversely, some insects damage and/or kill trees and reduce the capacity of forests to provide desired ecosystem services. The target audience of this book is upper-level undergraduate and graduate students and professionals interested in forest health and entomology.
    Type of Medium: Online Resource
    Pages: XII, 810 p. 149 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031115530
    DDC: 590
    Language: English
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  • 21
    Keywords: Anatomy. ; Medical education. ; Medicine Research. ; Biology Research. ; Information visualization. ; Biophysics. ; Education Data processing. ; Anatomy. ; Medical Education. ; Biomedical Research. ; Data and Information Visualization. ; Bioanalysis and Bioimaging. ; Computers and Education.
    Description / Table of Contents: Part I. The History and Philosophy of Medical Imaging -- Chapter 1. Re:Viewing Observation. The Philosophy of Medical Imaging -- Part II. Innovation in Imaging Technologies -- Chapter 2. Emerging Imaging Techniques in Anatomy: For Teaching, Research and Clinical Practice -- Chapter 3. Mapping of Orthopaedic Fractures for Optimal Surgical Guidance -- Chapter 4. Visualising the Dural Venous Sinuses Using Volume Tracing, a Novel Approach -- Chapter 5. Placental Morphology and Morphometry: Is It a Prerequisite for Future Pathological Investigations? -- Part III. Art-Based Practice and Body Science -- Chapter 6. Drawing: A Dialogue across Disciplines -- Chapter 7. Visualizing the Human Body Using an Artistic Approach -- Chapter 8. Construction of Facial Composites from Eyewitness Memory.
    Abstract: This book brings together current advances in high-technology visualisation and the age-old but science-adapted practice of drawing for improved observation in medical education and surgical planning and practice. We begin this book with a chapter reviewing the history of confusion around visualisation, observation and theory, outlining the implications for medical imaging. The authors consider the shifting influence of various schools of philosophy, and the changing agency of technology over time. We then follow with chapters on the practical application of visualisation and observation, including emerging imaging techniques in anatomy for teaching, research and clinical practice - innovation in the mapping of orthopaedic fractures for optimal orthopaedic surgical guidance - placental morphology and morphometry as a prerequisite for future pathological investigations - visualising the dural venous sinuses using volume tracing. Two chapters explore the use and benefit of drawing in medical education and surgical planning. It is worth noting that experienced surgeons and artists employ a common set of techniques as part of their work which involves both close observation and the development of fine motor skills and sensitive tool use. An in-depth look at police identikit construction from memory by eyewitnesses to crimes, outlines how an individual’s memory of a suspect’s facial features are rendered visible as a composite image. This book offers anatomy educators and clinicians an overview of the history and philosophy of medical observation and imaging, as well as an overview of contemporary imaging technologies for anatomy education and clinical practice. In addition, we offer anatomy educators and clinicians a detailed overview of drawing practices for the improvement of anatomical observation and surgical planning. Forensic psychologists and law enforcement personnel will not only benefit from a chapter dedicated to the construction of facial composites, but also from chapters on drawing and observation. .
    Type of Medium: Online Resource
    Pages: XI, 190 p. 86 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031130212
    Series Statement: Advances in Experimental Medicine and Biology, 1392
    DDC: 611
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Neurology . ; Internal medicine. ; Immunology. ; Biomedical Research. ; Biomedical Research. ; Neurology. ; Internal Medicine. ; Immunology.
    Description / Table of Contents: Chapter 1. Malignant Glioma -- Chapter 2. Benign Glioma -- Chapter3. Meningioma and Other Meningeal Tumors -- Chapter4. Epondymomas in Pediatric and Adults -- Chapter5. Medulloblastomas in Pediatric and Adults -- Chapter6. Benign and Malignant Tumors of The Pineal Region -- Chapter7. The Tumors of Choroid Plexus and Other Ventricular Tumors -- Chapter8. Embryonal Tumors of The Central Nervous System with Multilayered Rosettes and Atypical Teratoid/Rhabdoid Tumors -- Chapter9. Glioneuronal and Neuronal Tumors of the Central Nervous System -- Chapter10. Benign and Malignant Tumors of the Pituitary Gland -- Chapter11. Craniopharyngioma in Pediatric and Adults -- Chapter12. Schwannomas of Brain and Spinal Cord -- Chapter13. Other Nerve-Sheet Tumors of Brain and Spinal Cord -- Chapter14. Hemangioblastomas and Other Vascular Originating Tumors of Brain or Spinal Cord -- Chapter15. Brain and Spinal Cord Tumors of Embryonic Origin -- Chapter16. Brain and Spinal Tumors Originating from the Germ Line Cells -- Chapter17. Benign Brain and Spinal Tumors Originating from Bone or Cartilage -- Chapter18. Benign Spinal Tumors -- Chapter19. Other Less Prevalent Tumors of the Central Nervous System -- Chapter20. Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes -- Chapter21. Psychological and Psychiatric Aspects of Brain and Spinal Cord Tumors -- Chapter22. A Brief Explanation on Surgical Approaches for Treatment of Different Brain Tumors.
    Abstract: This book aims to gather the current knowledge regarding different aspects of brain and spinal cord tumors in order to more efficiently help the patients. Brain tumors comprise about 5–9% of all human neoplasms; and the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. The more we know about the nature and characteristic of brain and spinal cord tumors, the more precise decision could be made for each patient, in order to reach the best outcome. While surgical resection, chemotherapy, and radiotherapy have been considered as the standards of care for benign and/or malignant CNS tumors since a long time ago, new therapeutic approaches such as immunotherapy have been recently proposed to be considered for treatment of CNS tumors, especially as in some cases, the tumors might be inoperable or the patient may not benefit from other treatment modalities after several recurrences. The second volume of the book focuses on clinical aspects of these tumors. Accordingly, the most important brain and spinal cord tumors are specifically discussed in each chapter based on a rational outlining for all chapter in this volume: Background and epidemiology, genetics, immunology and molecular biology, histopathology and morphology, imaging and radiologic features, clinical manifestations, therapeutic approaches, surgical intervention, chemotherapy and radiotherapy, new therapeutic modalities, follow-up, and prognosis. The chapters of this volume discuss the following pathologies of brain and spinal cord tumors: malignant glioma, benign glioma, meningiomas and other meningeal tumors, ependymomas, medulloblastomas, pineal tumors, choroid plexus and ventricular tumors, neuroectodermal tumors of CNS, neuroepithelial tumors of CNS, pituitary gland tumors, craniopharyngioma, schwannomas and nerve-sheet tumors, hemangioblastomas and other vascular originating tumors, brain and spinal tumors of embryonic origin, germ line cell tumors, malignant bone or cartilage-originating tumors of brain and spine, benign bone or cartilage-originating tumors of brain and spine, brain tumors affecting the orbit globe and orbit tumors affecting the brain, CNS lymphomas, metastatic lesions of the brain and spine, malignant spinal tumors, benign spinal tumors, brain and/or spinal cord tumors accompanied with other diseases or syndromes, psychological and psychiatric aspects of brain and spinal cord tumors, a brief explanation on surgical approaches for treatment of different brain tumors. This volume of book is useful for physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists, and neuroradiologists.
    Type of Medium: Online Resource
    Pages: XXIX, 739 p. 287 illus., 159 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031237058
    Series Statement: Advances in Experimental Medicine and Biology, 1405
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Genomics. ; Cancer. ; Immunology. ; Nutrition   . ; Physiology. ; Biomedical Research. ; Genomics. ; Cancers. ; Immunology. ; Nutrition. ; Physiology.
    Description / Table of Contents: 1. The human genome and its variations -- 2. Gene expression and chromatin -- 3. The basal transcriptional machinery -- 4. Transcription factors and signal transduction -- 5. A key transcription factor family: Nuclear receptors -- 6. DNA methylation -- 7. Histone modifications -- 8. Chromatin remodeling and organization -- 9. Regulatory impact of non-coding RNA -- 10. Genome-wide principles of gene regulation -- 11. Epigenetics in development -- 12. Epigenetics and aging -- 13. Epigenetics and disease -- 14. Cells and tissues of the immune system -- 15. Innate immunity and inflammation -- 16. Adaptive immunity and antigen receptor diversity -- 17. B cell immunity: BCRs, antibodies and their effector functions -- 18. Antigen-presenting cells and MHCs -- 19. T cell immunity: TCRs and their effector functions -- 20. Immunity to bacterial pathogens and the microbiome -- 21. Immunity to viral pathogens and the virome -- 22. Tolerance and transplantation immunology -- 23. Immunological hypersensitivities: Allergy and autoimmunity -- 24. Introduction to cancer -- 25. Oncogenes, signal transduction and the hallmarks of cancer -- 26 Tumor suppressor genes and cell fate control -- 27. Multistep tumorigenesis and genome instability -- 28. Cancer genomics -- 29. Cancer epigenomics.-30. Aging and cancer -- 31. Tumor microenvironment -- 32 Metastasis and cachexia -- 33. Cancer immunology -- 34 Architecture of cancer therapies -- 35 Nutrition and common diseases -- 36 Interference of the human genome with nutrients -- 37. Nutritional epigenetics, signaling and aging -- 38. Chronic inflammation and metabolic stress -- 39. Obesity -- 40. Insulin resistance and diabetes -- 41. Heart disease and the metabolic syndrome -- 42 Epigenetics, inflammation and disease.
    Abstract: The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all processes in physiology, both in health as well as in most common disorders, such as cancer, diabetes as well as in autoimmune diseases. Most non-communicable human diseases have a genetic (= inherited) as well as an epigenetic component. The later one is based on our lifestyle choices and environmental exposures. Many common diseases, such as type 2 diabetes, can be explained only to some 20% via a genetic predisposition. We cannot change the genes that we are born with but we can take care of the remaining 80% being primarily based on our epigenome. Therefore, there is a high level of individual responsibility for staying healthy. Thus, not only biologists and biochemists should be aware of this topic, but all students of biomedical disciplines will benefit from being introduced into the concepts of molecular medicine. This will provide them with a good basis for their specialized disciplines of modern life science research. The book is subdivided into 42 chapters that are linked to a series of lecture courses in “Molecular Medicine and Genetics”, “Molecular Immunology”, “Cancer Biology” and “Nutrigenomics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. This book represents an updated version and fusion of the books textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8). “Molecular Immunology: How Science Works” (ISBN 978-3-030-XXX), “Cancer Biology: How Science Works” (ISBN 978-3-030-75699-4) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4). By combining basic understanding of cellular mechanism with clinical examples, the authors hope to make this textbook a personal experience. A glossary in the appendix will explain the major specialist’s terms.
    Type of Medium: Online Resource
    Pages: XXXIV, 700 p. 301 illus., 300 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031271335
    DDC: 610.72
    Language: English
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    Keywords: Geology. ; Sedimentology. ; Paleontology . ; Geophysics. ; Geology. ; Sedimentology. ; Paleontology. ; Geophysics.
    Description / Table of Contents: Chapter 1. Surface Geology of Kuwait -- Chapter 2. Subsurface stratigraphy of Kuwait -- Chapter 3. Sand dunes in Kuwait, morphometric and chemical characteristics -- Chapter 4. Marine Geology of Kuwait -- Chapter 5. Structures and Tectonics of Kuwait.
    Abstract: This open access book contains a set of chapters covering all aspects of geosciences related to Kuwait and adjactent regions, including Iran, Saudi Arabia and the Arab Gulf states. It covers basic information about the geology including a wide range of geoscientific disciplines such as marine geology, structural geology, hydrogeology and geophysics related to the region. This book is aimed at researchers and students, as well as professionals in the field of hazard mitigation and petroleum exploration.
    Type of Medium: Online Resource
    Pages: XII, 242 p. 211 illus., 177 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031167270
    Series Statement: Regional Geology Reviews,
    DDC: 551
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geology. ; Sedimentology. ; Paleontology . ; Petrology. ; Geology. ; Sedimentology. ; Paleontology. ; Petrology.
    Description / Table of Contents: Chapter 1 - Field guide for a complete cross-section of the Central Andes along main roads (Carla Cristine Porcher, Márcia Elisa Boscato Gomes, Amós Martini, Giuseppe Betino De Toni, João Pacífico Machado) -- Chapter 2 – Structures associated with the dynamics of granitic rock emplacement (NW Portugal) (Jorge Pamplona, Benedito C. Rodrigues, Mark Peternell, Alex Lorenz, Alex Schimdt, Melissa Mengert, Thomas Altmeyer, Jonas Köpping) -- Chapter 3 - Tectonically significant fault zones in Central Europe (Germany, Czech Republic and Poland) and their surface and subsurface outcrops: Franconian Line, Hronov-Porici Fault, Sudetic Marginal Fault and Lusatian Fault (Lucie Novakova) -- Chapter 4 - Geological field observations along the Pandoh Syncline:the Mandi-Kataula-Bajura section of Himachal Pradesh, NW-India (Paramjeet Singh, Pratap Chandra Sethy, Hrithik Rastogi, M. Rajanikanta Singh, A. Krishnakanta Singh, Satyajit Singh Thakur, Saurabh Singhal) -- Chapter 5 - The rock outcrops at Raghunathdi, SE of Ghatsila (Jharkhand, India): A spectacular preservation of polyphase folding (Srinanda Ganguly, Arpita Samanta, Abhik Kundu) -- Chapter 6 - Spectacular soft-sediment deformation structures in sedimentary rock outcrops of Damodar Valley Basin, West Bengal, India: A field guide (Arpita Samanta, Abhik Kundu) -- Chapter 7 - Structural geological field guide: Bhuj area (Gujarat, India) (Nidhi Lohani, Soumyajit Mukherjee, Seema Singh, Aashu Pawar, Mohamedharoon Shaikh) -- Chapter 8 - Structural and sedimentary field studies in Angul District, Odisha, India (Subhajit Sinha, Ananya Ghosh, Somnath Mishra) -- Chapter 9 - New Structural geological input from the Barmer Basin, Rajasthan (India) (Mohit Kumar Puniya, Ashish Kumar Kaushik, Soumyajit Mukherjee, Swagato Dasgupta, Nihar Ranjan Kar, Mery Biswas, Ratna Choudhary) -- Chapter 10 - Structural geology and stability issue of the Giral lignite mine, Rajasthan, India (Mohit Kumar Puniya, Ashish Kumar Kaushik, Soumyajit Mukherjee, Nihar Ranjan Kar, Mery Biswas, Ratna Choudhary) -- Chapter 11 - Relationship between deformation structures and rock mass rating: A case study of underground power house, Andhra Pradesh- India (Mohit Kumar Puniya, Sohan Kumar, Ashish Kumar Kaushik, Nikhil Puniya) -- Chapter 12 - Macrostructures mimic Meso-structures (Harsh Bhu, Ritesh Purohit, Riya Dutta) -- Chapter 13 - Review on Role of multi-constellation Global Navigation Satellite System-Reflectometry (GNSS-R) for real-time sea-level measurements (Kutubuddin Ansari) -- Chapter 14 - Architecture and structures of Kiradu temple (Barmer region, Rajasthan, India) (Paramita Haldar,, Mohit Kumar Puniya, Mery Biswas, Soumyajit Mukherjee, Nihar Ranjan Kar, Ratna Choudhary).
    Abstract: This book is the second volume of an edited work aiming to help novice geologists to explore terrains independently. Geoscience fieldwork with focus on structural geology and tectonics has become more important in the last few years from both academic and industrial perspectives. This book also works as a resource material for batches of students or geological survey professionals undergoing training as parts of their course curriculum/training. Industry persons, on the other hand, can get a first-hand idea about what to expect in the field, in case no academic persons are available with the team. This book focuses on structural geology and tectonics and compiles terrains from several regions of the globe. This book also includes field guide chapters for primary sedimentary structures.
    Type of Medium: Online Resource
    Pages: XVI, 418 p. 323 illus., 304 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031195761
    Series Statement: Springer Geology Field Guides, FieldGuides,
    DDC: 551
    Language: English
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  • 26
    Keywords: Earth sciences. ; Geography. ; Mining engineering. ; Underground construction. ; Geographic information systems. ; Mineralogy. ; Geology. ; Earth and Environmental Sciences. ; Mining and Exploration. ; Underground Engineering and Tunnel Construction. ; Geographical Information System. ; Mineralogy. ; Geology.
    Description / Table of Contents: Chapter 1: 202 Application of Unmanned Aerial Vehicles for Surveying and Mapping in Mines: A Review -- Chapter 2: 147 Traditional and Advanced Techniques for Extraction of Large Dimension Stone Blocks for Rock-cladding and Monumental Purposes -- Chapter 3: 017 Mining-induced Land Subsidence Detected by Persistent Scatterer InSAR: Case Study in Pniówek Coal Mine, Silesian Voivodeship, Poland -- Chapter 4: 156 Slope Stability Evaluation of Fenghuangshan Landfill Under Rainfall Condition: A Case Study -- Chapter 5: 117 Forecasting PM10 Concentration from Blasting Operations in Open-Pit Mines Using Unmanned Aerial Vehicles and Adaptive Neuro-Fuzzy Inference System -- Chapter 6: 066 Assessing the Effect of Open-pit Mining Activities and Urbanization on Fine Particulate Matter (PM2.5) Concentration by Using Remote Sensing Imagery. A Case Study in Binh Duong Province, Vietnam -- Chapter 7: 016 Effect of Loading Frequency on the Liquefaction Resistance of Poorly Graded Sand -- Chapter 8: 144 An Automatic Method for Clay Minerals Extraction from Landsat 8 OLI Data. A Case Study in Chi Linh City, Hai Duong Province -- Chapter 9: 009 Evaluation of the Precision of SARAL/AltiKa and Sentinel-3A Satellite Altimetry Data over the Vietnam Sea and Its Surroundings -- Chapter 10: 070 Detection of GNSS-TEC Noise Related to the Tonga Volcanic Eruption Using Optimization Machine Learning Techniques and Integrated Data -- Chapter 11: 149 Stability of Road Embankments on Weak Soils -- Chapter 12: 053 Indirect Georeferencing in Terrestrial Laser Scanning: One-step and Two-step Approaches -- Chapter 13: 196 Technological Solutions for Fly Ash and Red Mud Upcycling Approach the Vietnam's Government Target of Net-zero Carbon By 2050 -- Chapter 14: 153 Pile-soil Interaction Mechanism and Optimization Measures Based on Finite Element Method -- Chapter 15: 055 Determination of Illegal Signs of Coal Mining Expansion in Thai Nguyen Province, Vietnam From a Combination of Radar and Optical Imagery Mine Production Tracking Platform and Its Initial Application in the Digital Transformation for a Vietnamese Coal Exploitation Company Chapter 21: 163 Shear Strength of Poorly Graded Granular Material in Multi-stage Direct Shear Test -- Chapter 22: 152 High–resolution Seismic Reflection Survey of Young Sediment at Can Gio Coast, Ho Chi Minh City, Vietnam -- Chapter 23: 140 Analysis of Geological Structures by 2D Magnetotelluric Inversion in Bang Hot Spring Area, Quang Binh Province -- Chapter 24: 119 Physicochemical characteristics of the Middle Triassic Limestone in Ha Nam Province, Vietnam and the Ability of Adsorption of Heavy Metal Ions from Aqueous Environments -- Chapter 25: 159 Local Mechanical Behaviors of Steel Box Girder During Skew Incremental Launching -- Chapter 26: 094 GIS Applications in Land Adaptability Mapping for Perennial Industrial Crops in Nghe An Province -- Chapter 27: 083 Land-use and Land-cover Change Detection and Classification to Analyze Dynamics of Dragon Fruit Farming in Sand Dunes Area of Binh Thuan Province of Vietnam -- Chapter 28: 059 Random Forest Analysis of Land Use and Land Cover Change Using Sentinel-2 Data in Van Yen, Yen Bai Province -- Chapter 29: 155 Engineering Geological Problems of Foundation Pit Construction in Quaternary Strata: Taking Suzhou Area as An example Chapter 30: 034 Roof Condition Characteristics Affecting the Stability of Coal Pillars and Retained Roadway -- Chapter 31: 194 On the Flow Assurance for Un-Insulated Subsea Pipeline Systems: Application on the Multiphase Pipeline from Pearl Field to FPSO Ruby II Offshore Vietnam -- Chapter 32: 017 Detection of Underground Anomalies by Evaluation of Ground Penetrating Radar Attribute Combination -- Chapter 33: 157 Dynamic Failure Process of Soil Particles at the End of Shield Tunnel Based on Discrete Element -- Chapter 34: 205 Early Triassic Tectonic Evolution in the Northeastern Kontum Massif: New Constrains from the S-type Granite in Ba To Area, Quang Ngai Province, Central Vietnam -- Chapter 35: 035 Proposal of Study on InSAR-based Land Subsidence Analysis as Basis for Subsequent Hydro-mechanical Modeling: A Case Study of the Hanoi City, Vietnam.
    Abstract: This volume composes the proceedings of the international Conference on Geo-Spatial Technologies and Earth Resources (GTER 2022) which was co-organized by Hanoi University of Mining and Geology, and the International Society for Mine Surveying (ISM) held at Hanoi city on October 13–14, 2022. GTER 2022 is technically co-sponsored by Vietnam Mining Science and Technology Association (VMST), Vietnam Association of Geodesy, Cartography and Remote Sensing (VGCR), Vietnam National Coal-Mineral Industries Holding Corporation Limited (VINACOMIN), and the Dong Bac Corporation (NECO). GTER 2022 aims to bring together experts, researchers, engineers, and policymakers to discuss and exchange their knowledge and experiences in recent Geospatial technologies, advances in Mining and Earth Sciences.
    Type of Medium: Online Resource
    Pages: XVI, 548 p. 300 illus., 270 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031204630
    Series Statement: Environmental Science and Engineering,
    DDC: 500
    Language: English
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    Keywords: Geology. ; Petrology. ; Paleontology . ; Earth sciences. ; Geology. ; Petrology. ; Paleontology. ; Earth Sciences.
    Description / Table of Contents: Overall paleogeographic and geodynamic evolution -- Major Groundwater reservoirs in Egypt -- Western Desert Petroleum sources and reservoirs -- Nile Delta Petroleum sources and reservoirs -- Gulf of Suez and Red Sea Petroleum sources and reservoirs -- Off-shore Mediterranean discoveries -- Petroleum Source Rocks of Egypt – An Integrated Palynological and Organic Geochemical Approach: Spatio-temporal studies within the Phanerozoic of Egypt -- Carbonate platform deposits and hydrocarbon potentiality -- Hydrocarbon seepage during the Messinian salinity crisis -- Rare Earth Element in Egypt -- Phanerozoic Stratabound/Stratiform Ore Deposits of Egypt.
    Abstract: The Phanerozoic Geology and Natural Resources of Egypt includes a series of chapters written by highly qualified group of researchers whose expertise is recognized and appreciated not only in Egypt, but also in the world over. The chapters span a wide range of geological subdisciplines including tectonics, paleogeography, stratigraphy, sedimentology, paleontology, groundwater, and energy resources, just to name a few. In this regard, the book provides the reader with ample knowledge about the different facets of the fascinating and always intriguing geology of Egypt since the Precambrian time. For a junior researcher or a geoscience student, the book is a comprehensive, multidisciplinary one-stop resource that they will continue to reference and rely on for years to come. For a more experienced scientist, the book summarizes the current state of knowledge, highlights the magnitude of complexity of the geology of Egypt and northeast Africa, and reveals potential areas where future research should be directed. The book is written in simple, easy to understand English language and contains very useful high-quality illustrations. Last but not least, The Phanerozoic Geology and Natural Resources of Egypt has been reviewed and edited by world class, highly ranked geoscientists from Egypt, Europe, and USA.
    Type of Medium: Online Resource
    Pages: XIX, 742 p. 593 illus., 529 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030956370
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    DDC: 551
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geology. ; Geotechnical engineering. ; Geophysics. ; Water. ; Hydrology. ; Geology. ; Geotechnical Engineering and Applied Earth Sciences. ; Geophysics. ; Water.
    Description / Table of Contents: Introduction. The Premise of Well Tests -- Chapter 1. Qualitative Aspects: Pattern Recognition -- Chapter 2. Quantitative Aspects: Parameter Estimation -- Chapter 3. Special Cases of Gas and Gas Condensate Wells -- Chapter 4. Naturally Fractured Reservoirs -- Chapter 5. Hydraulically Fractured Wells -- Chapter 6. Horizontal Wells -- Chapter 7. Interference and Pulse Tests -- Chapter 8. Unconventional Wells -- Chapter 9. Injection Well tests -- Chapter 10. Drill Stem Tests -- Chapter 11. Pumping Well Tests -- Chapter 12. Geothermal Wells -- Chapter 13. Computer Aided Methods -- Chapter 14. Testing Water wells and Aquifers -- Chapter 15. Subsurfcae Fluid Disposal and Energy Storage -- Chapter 16. Designing Well Tests.
    Abstract: This book is about the technology of using fluid production or injection and pressure measurement signals from wellbores and relating those signals to the subsurface geology and subterranean reservoir properties. It is aimed at students of well-testing and practicing petroleum engineers or geoscience professionals for subsurface characterization and modeling. The topics include the art and science of well-test analysis, pattern recognition of rate and pressure signals, and a quantitative approach for estimating important subsurface geological parameters for subsurface aquifers and reservoirs containing oil, gas, and geothermal resources. The book is also particularly of value as a guide to asset managers actively developing unconventional reservoirs and CCUS.
    Type of Medium: Online Resource
    Pages: XVII, 191 p. 184 illus., 145 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031472992
    DDC: 551
    Language: English
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    Keywords: Water. ; Hydrology. ; Geology. ; Geotechnical engineering. ; Sustainability. ; Water. ; Geology. ; Geotechnical Engineering and Applied Earth Sciences. ; Sustainability.
    Description / Table of Contents: Chapter 1. Evapotranspiration importance in water resources management through cutting-edge approaches of Remote sensing and machine learning algorithms (Ali Raza) -- Chapter 2. Application of Remote Sensing and GIS for Morphometric Analysis: A Case Study of Burhanpur Watershed (Abhishek Patel) -- Chapter 3. A GIS-based DRASTIC approach for Aquifer vulnerability assessment: Study conducted in the Municipal Corporation region of Ranchi, Jharkhand (Shivam Saw) -- Chapter 4. Evaluation of Infiltration Models in an Agricultural Catchment Using Guelph Permeameter in Mysuru District (Harshith Y) -- Chapter 5. Investigation of trends and variability associated with the SPI and SPEI as a drought prediction tools in Gujarat regions, India (Paras Hirapara) -- Chapter 6. Fluoride mobilization and provenance identification in semi-arid conditions: A Hydrochemical and Isotopic approach (Abhinav Patel) -- Chapter 7. A comparative study of different inverse groundwater models for aquifer parameter estimation (Sharad Patel) -- Chapter 8. Water resources and irrigation management using GIS and Remote Sensing techniques: Case of Multan district (Pakistan) (Ali Raza).
    Abstract: This book explains the challenges for efficient sustainable surface and groundwater development and management with the focus on India and other countries, providing a stable output presentation by using machine learning data mining methods, and modeling. It is a combination of machine learning, modeling, google earth engine, climate data modeling, remote sensing and GIS techniques, surface water modeling, AHP modeling, groundwater quality analysis, aquifer mapping, land use and land cover analysis, forecasting of water and rainfall and so on, its use to sustainable development, planning, and management of groundwater purposes in India and other countries. The main purpose of this book will develop better outlines for the development of surface and groundwater and management in the semi-arid region climate, which supports the Sustainable Development Goals (SDGs) in India, especially on sustainable surface water and groundwater resources management. This book provides a multidisciplinary overview for the faculty members, administrators scientists, policymakers, social science, and professionals involved in the various aspects of sustainable groundwater development, planning, and management.
    Type of Medium: Online Resource
    Pages: IX, 427 p. 172 illus., 161 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031293948
    Series Statement: Springer Hydrogeology,
    DDC: 551.48
    Language: English
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    Keywords: Geology. ; Human ecology Study and teaching. ; Environment. ; Environmental management. ; Geology. ; Environmental Studies. ; Environmental Sciences. ; Environmental Management.
    Description / Table of Contents: An Overview of World Deserts with Special Reference to Thar Desert -- People and Culture of the Thar Desert -- Shift in Land Use Pattern of Thar Desert -- Land and Water Resource Management in the Thar Desert Region -- Crop Production Practices in the Thar Desert Region of Rajasthan -- Livestock and its Management Practices in Thar Desert, Rajasthan -- Arid Agroforestry for Thar Desert -- Soil Conservation and Water Harvesting for Sustainable Agriculture in Arid Regions -- Community Land Management in the Thar Desert -- Women Empowerment in Thar Desert Region -- Livelihood Opportunities in the Thar Region -- Potential Agri-Business in the Thar Desert -- Multidimensional Development in Thar Desert Region of Rajasthan -- Sustainable Natural Resource Management in Thar Desert-Way Ahead. .
    Abstract: This book covers a wide range of issues related to the Thar Desert Region of Rajasthan from an integrated and sustainable development perspective. The chapters in this book cover regional and local issues which are discussed with reference to the past scenario, the present practices, and the future strategies. Some of the issues addressed in this book like arid agroforestry, livelihood, and multidimensional development give it a cutting edge over other related publications currently available in the market. The chapters are supported with relevant pictures which will help the reader to connect with the issues being discussed. This book is useful to students, civil services aspirants, researchers, environmentalists, geographers, and non-professionals who are interested in deserts and desert development.
    Type of Medium: Online Resource
    Pages: XXII, 342 p. 52 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031345562
    DDC: 551
    Language: English
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    Keywords: Geology. ; Sedimentology. ; Mining engineering. ; Geotechnical engineering. ; Power resources. ; Geology. ; Sedimentology. ; Mining and Exploration. ; Geotechnical Engineering and Applied Earth Sciences. ; Natural Resource and Energy Economics.
    Description / Table of Contents: Chapter 1. The Mediterranean Sea: a laboratory to characterize micro-continental drift and oceanic basin formation processes -- Chapter 2. The westernmost Tethyan margins in the Rif Belt (Morocco), a review -- Chapter 3. The Tellian units, the Sellaoua window and the High Medjerda foreland in the Souk Ahras area, NE Algeria -- Chapter 4. Facies Analyses and Basin Evolution of the Cretaceous-Tertiary Rift-related Sedimentary Succession of Haddat Ash Sham area, West Central Arabian Shield, Saudi Arabia -- Chapter 5. Petroleum system evaluation of Upper Cretaceous and Eocene plays, offshore and onshore southern Pelagian Basin, Tunisia.
    Abstract: This book summarizes the links between the evolution of sedimentary basins of Northern Africa and Peri-Mediterranean in different tectonic settings and the distribution of georesources in those basins. Georesources include fossil energy, geothermal energy, deep aquifers, minerals and deposits. This book also provides key information for energy resources in these important areas. The book is in part a compilation of selected papers from Atlas Georesources International Congress, Hammamet, Tunisia, (AGIC 2017) which were extended after the congress in addition to other contributions from geoscientists based at some universities and companies from the region. It is organized in a set of research studies focusing on the architecture, geodynamic evolution and modeling of sedimentary basins in the Middle East, North Africa and the Mediterranean domain. Future developments in the exploration for water, energy and other georesources are very important in these regions. In this context, this book constitutes an important reference for a wide range of geoscientists and companies as it defines the distribution and potentialities of these resources. .
    Type of Medium: Online Resource
    Pages: XVIII, 284 p. 233 illus., 224 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031187476
    Series Statement: Regional Geology Reviews,
    DDC: 551
    Language: English
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    Keywords: Environment. ; Soil science. ; Geology. ; Atmospheric science. ; Environmental Sciences. ; Soil Science. ; Geology. ; Atmospheric Science.
    Description / Table of Contents: Atmosphere -- Pyrocumulus: A New Cloud in Galician Skies -- Introduction to the Geology of Galicia -- Al-rich Speleothems in Granite Caves: A Poorly Known Geologic Material and Environment -- Caves: Underground Landscapes -- The Courel Mountains UNESCO Global Geopark: An Amazing Geological History Extended Along 600 Million Years -- Endogenous/exogenous Forms of Granite Geomorphology in Galicia.
    Abstract: This book describes the environment in Galicia (NW Spain), with researchers and professors presenting their own photographs of relevant aspects. This richly illustrated book explains atmospheric, geologic, water, soils, landscapes, and environmental issues and treatments for a broad audience, including students and the general public, to raise awareness and effectively develop strategies to meet the Sustainable Development Goals.
    Type of Medium: Online Resource
    Pages: XI, 640 p. 404 illus., 398 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031331145
    DDC: 333.7
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Physical geography. ; Environmental monitoring. ; Biotic communities. ; Geology. ; Environment. ; Freshwater ecology. ; Marine ecology. ; Earth System Sciences. ; Environmental Monitoring. ; Ecosystems. ; Geology. ; Environmental Sciences. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Introduction -- Freezing of lakes -- Structure and properties of lake ice -- Thermodynamics of Seasonal lake ice -- Mechanics of lake ice -- Proglacial lakes -- Lake Water Body in the Ice Season -- Ice-Covered Lakes Environment -- Lake ice Climatology -- Future of frozen lakes -- Annex: Ice Properties and Useful Formulae -- References -- Index.
    Abstract: This book updates the first edition for the status of knowledge in the physics of lake ice and the interactions between the ice cover and the liquid water underneath. Since the first edition was written in 2013, there has been a lot of progress in the field, in particular concerning environmental questions and the impact of climate change. Life conditions in ice-covered lakes and practical matters are now brought more into the picture so that the revision also properly serves as a handbook for applications. The author has worked widely with boreal lakes, polar lakes and Central Asian lakes that provides a wide geographical spectrum. Chapter 1 gives a brief overview and presents the research fields. The second chapter contains the classification of ice-covered lakes and observation techniques, especially remote sensing. In Chapter 3, the structure and properties of lake ice are presented including optics and geochemistry. Ice growth and melting are treated in Chapter 4, while the following chapter focuses on ice mechanics with applications to traffic on ice and ice loads. Chapter 6 goes into the exotic environment of pro-glacial lakes. Chapter 7 contains the stratification and circulation of the water body beneath lake ice, Chapter 8 presents the winter ecology of freezing lakes and discusses the lake ice interface toward the society, and Chapter 9 summarizes the climate change impact on lake ice seasons. The book ends into a brief closing chapter and list of references. Research problems for student learning are listed throughout the book. Annexes are included to provide numerical data of constants and standard formulae to help practical calculations and student tasks. Lake ice closely interacts with human living conditions, but people have learnt to live with that and to utilize the ice. In the present time this is true for on-ice traffic and recreation activities. Ice fishing has become a widely enjoyed hobby, and winter sports such as skiing, skating, and ice sailing are popular activities on frozen lakes. The lake ice response to eventual climate warming would appear as a shortening of the ice season due to the increasing air temperature and also as changing of the quality of the ice seasons via changes in ice thickness and structure. The book gives the whole story of lake ice into a single volume. The second, revised edition updates the content based on recent progress in winter limnology and ice physics research and applications. The author has contributed to lake ice research since the 1980s. In particular, his topics have been lake ice structure and thermodynamics, light transfer in ice and snow, ice mechanics in large lakes, and lake ice climatology. Mathematical modeling of ice growth, drift, and decay are covered in this research.
    Type of Medium: Online Resource
    Pages: XII, 361 p. 160 illus., 116 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031256059
    Series Statement: Springer Praxis Books
    DDC: 550
    Language: English
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    Keywords: Geology. ; Water. ; Hydrology. ; Geomorphology. ; Geotechnical engineering. ; Geology. ; Water. ; Geomorphology. ; Geotechnical Engineering and Applied Earth Sciences.
    Description / Table of Contents: Part I: Karst hydrogeology and methods to study karst aquifers -- Initiative to select, label and protect the world’s most important karst springs -- Flood hazard in the Classical Karst: the case of Mucille polje (NE Italy) -- Impacts of Recharge and Discharge on Sustainability of the Trinity Aquifers of Central Texas -- Hydrodynamic characterization of sources of karst: case of the source of Ain Sebou (middle Atlas, central, Morocco) -- Surprising time lag between precipitation and groundwater levels in a karst aquifer of Kopa Mt. (Slovakia) -- Updating the water budget of the Gran Sasso carbonate fractured/karstified aquifer (Central Italy) for a sustainable management of groundwater resources -- Combining quantitative analysis tools (cross-correlation analysis and dye tracer tests) to assess response times in karst aquifers -- Quantitative and Geochemical Characterization of the Mokra Karst Aquifer (SE Serbia) by Time Series Analysis and Stochastic Modelling -- Characterization of the isotopic signature of effective rainfall (δ18O, δ2H) to constrain the groundwater re-charge zones in a Mediterranean karst aquifer -- Application of statistical approaches to piezometry to improve the understanding of the karst aquifer hydrodynamic behavior at the Cadarache CEA center (France) -- Characterization of hydrogeological processes of karst-influenced multi-layered aquifers of basin edge using statistical and geochemical approaches (northern Aquitaine basin, France) -- Implications of Tryptophan-Like-Fluorescence long term monitoring for bacterial detection in a mountainous rural karst aquifer -- What microbial signature means in terms of groundwater dynamics, vulnerability and residence time – Comparison of shallow and deep karst resources -- Deriving major ion concentrations at high resolution from continuous electrical conductivity measurements in karst systems -- ydrogeological characterization and modeling at two test sites of the Apulian karst (Southern Italy) -- Prediction of future interactions between karst and river regarding to climate change based on IPCC scenarios: application to a Mediterranean french river basin (Cèze) -- A smart analytical and numerical interpretation of injection tests in unsaturated, fractured and karstified carbonate reservoirs -- On the choice of performance metric for model calibration scheme using discharge age-information -- Understanding water table fluctuations in a karstic semiarid Mediterranean aquifer through numerical modelling: the case of Almudaina-Segaria aquifer -- Part II: Karst caves, geomorphology, landscape and natural heritage -- Understandig karst conduit size distribution by numerical speleogenesis modeling -- Unroofed cave – an underground form on the karst surface -- Study of Rull Cave dynamics to understand the complex relationships between soil, cave and external atmosphere -- Hydrological and environmental dynamics in the Güixas show cave: tourist exploitation and flood risk management -- Understanding morphosedimentary changes and extreme past floods: the case of Ojo de Valjunquera cave (Iberian Range, Spain) -- Identification of near-surface karst cavities using the posterior population expansion inverse method applied to electrical resistivity data -- Use of terrestrial LiDAR scanner for monitoring of ice thickness in ice caves; examples from Slovenia -- Evidences of past and present cave hypogenesis in the Serrezuela de Carratraca Massif (Málaga, Southern Spain) -- Microstratigraphic analysis of a speleothem from the Nerja Cave (Málaga, Southern Spain) -- Gypsum dissolution rate, new data and challenges -- A Multidisciplinary investigation of karstic subsidence in a Madrid urbanization #148 -- Morphometric comparison of dolines in three karst landscapes developed on different lithologies -- The importance of snow in the hydrogeology of a high relief karst system: Sierra de Tendeñera, in the Pyrenees Mountain range (Huesca, Northern Spain) -- The link between man and water in karst, through examples from Apulia (S Italy) -- Hydrogeological setting of Las Loras UNESCO Global Geopark (Palencia-Burgos, Spain): State of knowledge and needs for water resources sustainability research -- Preliminary hydrogeological investigations for sustainable development in the Courel Mountains UNESCO Global.
    Abstract: This book covers advances in the field of karst from a variety of perspectives to facilitate knowledge and promote interaction between disciplines. New methods are addressed that advance data collection, analysis, and interpretation in a wide range of karst contexts. Case studies are presented to provide examples of advancing science. Issues addressed include karst hydrogeology (water resources assessment, groundwater pollution and protection), methods to study karst aquifers (based on hydrodynamic, hydrochemistry, isotopes, dye tracing, geophysical surveys, and modeling techniques), karst geomorphology and landscape, mining and engineering in karst media (tunnels, dams, etc.), and karst cavities (touristic caves, natural heritage). This book is a resource for scientists around the world to compare problems, results, and solutions. Likewise, the examples included are used in policy decision making in karst regions. Finally, the contributions are used as a tool for university teaching.
    Type of Medium: Online Resource
    Pages: XIII, 254 p. 170 illus., 163 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031168796
    Series Statement: Advances in Karst Science,
    DDC: 551
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Biomedical Research. ; Biomedical Research. ; Biomedical Research. ; Medical Genetics.
    Description / Table of Contents: Chaptre 1. Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction -- Chaptre 2. Epidemiology of Brain and Spinal Cord Tumors -- Chaptre 3. The Role of Neuro-inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 4. The Role of Cellular Immunity and Adaptive Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 5. Immunotherapy as a New Therapeutic Approach for Brain and Spinal Cord Tumors -- Chaptre 6. Cell of Origin of Brain and Spinal Cord Tumors -- Chaptre 7. The Role of Bioinformatics and Imaging Models in Tumorigenesis and Treatment Response of Brain and Spinal Cord Neoplasms -- Chaptre 8. The Role of Epigenetics in Brain and Spinal Cord Tumors -- Chaptre 9. Stem Cells and Targeted Gene Therapy in Brain and Spinal Cord Tumors -- Chaptre 10. Nutrition and Diet: A Double-Edged Sword in Development and Treatment of Brain Tumors -- Chaptre 11. The Role of Nanotechnology in Brain Tumors -- Chaptre 12. The Role of Nanotechnology in Spinal Cord Tumors -- Chaptre 13. The Economic Burden of Malignant Brain Tumors.
    Abstract: Brain tumors comprise about 5–9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.
    Type of Medium: Online Resource
    Pages: XX, 231 p. 30 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031147326
    Series Statement: Advances in Experimental Medicine and Biology, 1394
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Clinical medicine Research. ; Biometry. ; Medicine Research. ; Biology Research. ; Statistics . ; Social sciences Statistical methods. ; Clinical Research. ; Biostatistics. ; Biomedical Research. ; Statistics in Engineering, Physics, Computer Science, Chemistry and Earth Sciences. ; Statistics in Business, Management, Economics, Finance, Insurance. ; Statistics in Social Sciences, Humanities, Law, Education, Behavorial Sciences, Public Policy.
    Abstract: This concise, easy-to-read pocket guide offers medical trainees, researchers, and clinicians at every level the perfect resource on Evidence Based Medicine (EBM). Based on the author’s many years of experience teaching EBM to medical students and medical residents at Columbia University, this handy title addresses not only all the basic concepts and issues in EBM, but also takes an example-based approach and is replete with numerous illustrations. This brief book provides readers with all the tools needed to tell the good from the bad in healthcare research. It discusses every type of study design, from the assessment of diagnostic tests to clinical trials and meta-analysis. The work also introduces readers to novel methods, such as the Bayesian analysis of clinical trials. In addition, to help readers better retain the information, the guide includes thought-provoking review questions and answers in an appendix. In all, Pocket Evidence-Based Medicine: A Survival Guide for Clinicians and Students is an ideal resource for anyone who encounters statistics in their studies or career, including clinicians, researchers, trainees in medicine and graduate students in a wide range of other disciplines.
    Type of Medium: Online Resource
    Pages: XIII, 221 p. 72 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031194719
    DDC: 615.50724
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Drug delivery systems. ; Vaccines Biotechnology. ; Biomaterials. ; Immunotherapy. ; Biomedical Research. ; Drug Delivery. ; Biomaterials-Vaccines. ; Immunotherapy.
    Description / Table of Contents: Chapter 1 A short introduction to vaccines -- Chapter 2 Thermostability of vaccines -- Chapter 3 Drying technologies for vaccines -- Chapter 4 Aseptic spray drying technology -- Chapter 5 Design of experiment studies and scale-up -- Chapter 6 Applications of spray dried vaccines.-Chapter 7 Conclusions and future perspectives of spray-dried vaccines.
    Abstract: This book addresses the stabilization of vaccine powders by spray drying and provides an overview of the current state of the art on a laboratory and industrial scale. The book aims to familiarize readers with the advances in vaccine spray drying technology to understand its application potential better. In particular, the book addresses the design of aseptic spray dryers, parameters affecting the spray drying process, sterile powder processing, cleaning procedures, and powder filling. In addition, different drying technologies for the production of dry powder vaccines are compared to discuss the unique capabilities of spray drying as a particle technology for vaccines. Special attention is given to research studies on spray-dried vaccines published over the past 30 years, with key findings from laboratory research to clinical trials. Potential applications of spray-dried vaccines and routes of administration are presented in detail. Finally, an outlook is given on how close the aseptic spray-drying of vaccines is to the market and the challenges that need to be overcome to be commercially successful. The book's target audience is academics, researchers, vaccine developers, industry experts, students, and possibly funders, including government agencies, who are active in the field. In addition, the book is a reference source for those involved in the vaccine formulation and biopharmaceutical processing industry.
    Type of Medium: Online Resource
    Pages: XXIX, 589 p. 243 illus., 176 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031243233
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Radiology. ; Medical education. ; Anatomy. ; Biomedical Research. ; Radiology. ; Medical Education. ; Anatomy.
    Description / Table of Contents: Part I. Microscopy -- Chapter 1. Advances in Microscopy and Its Applications with Special Reference to Fluorescence Microscope: An Overview -- Chapter 2. Visualisation of Host-Pathogen Communication -- Chapter 3. A Review of Pathology and Analysis of Approaches to Easing Kidney Disease Impact: Host-Pathogen Communication and Biomedical Visualization Perspective -- Part II. Radiology and Patient Care -- Chapter 4. The Evolution of Equipment and Technology for Visualising the Larynx and Airway -- Chapter 5. The Impact of Technological Innovation on Dentistry -- Chapter 6. Advanced 3D Visualization and 3D Printing in Radiology -- Chapter 7. 3D Visualisation of the Spine -- Part III. Anatomy Education -- Chapter 8. Visualization in Anatomy Education -- Chapter 9. Visualizing Anatomy in Dental Morphology Education -- Chapter 10. Flashcards: The Preferred Online Game-Based Study Tool Self-Selected by Students to Review Medical Histology Image Content.
    Abstract: This book highlights the integration of science and imaging and demonstrates how we can teach and learn in a much more accessible, innovative, and engaging way using technology. This volume is particularly focused on three main themes: advanced microscopy, anatomy education, and radiology visualisation related to patient care. The chapters pertaining to advanced microscopy convey complex biomedical information by visual means. These chapters provide both an overview on the principles of microscopy and specific applications of microscopy that have led to groundbreaking discoveries. Chapters pertaining to education summarise the recent trends in teaching gross and microscopic anatomy and emphasise the creation and use of novel tools to support student learning. Lastly, the radiological visualisation segment dives into the history of radiographic imaging and highlights the profound effect technology has had on improving patient outcomes. This volume will be of particular interest to many; the scope of this book encompasses medicine, dentistry, allied health professions, biomedical sciences, anatomy and histology education, radiology, and microscopy. Students, researchers, educators, and clinicians will learn something new, be stimulated to ask innovative questions, and be inspired to continue the technological advancements pushing science forward. .
    Type of Medium: Online Resource
    Pages: XI, 224 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031264627
    Series Statement: Advances in Experimental Medicine and Biology, 1406
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Human physiology. ; Cancer. ; Cancer Treatment. ; Virology. ; Therapeutics. ; Biomedical Research. ; Human Physiology. ; Cancer Biology. ; Cancer Therapy. ; Virology. ; Therapeutics.
    Description / Table of Contents: 1. Implications of renin-angiotensin system in health and disease -- 2. Renin angiotensin system and aging -- 3. The interplay of the renin-angiotensin system and solid organ transplantation -- 4. Correlation between renin angiotensin system and infectious disease -- 5. Emerging contributions of endocrine pathophysiology in virus-related infectious disease -- 6. Understanding the renin-angiotensin system in coronavirus disease 2019 -- 7. Metabolomics approach in differentiating RAS responses in ARDS (Acute respiratory distress syndrome) and SAR-CoV-2 -- 8. A Comprehensive review of the impact of the renin angiotensin system in the liver, lung, infectious diseases and cancers -- 9. Application of biosensors for monitoring changes in renin angiotensin system (RAS) in cancers and lung diseases -- 10. Bioinformatics study on renin angiotensin in lung, and liver cancer using plant-based extracts -- 11. Role of renin-angiotensin system in the pathogenesis and progression of non-alcoholic fatty liver -- 12. The classical and nonclassical renin-angiotensin-aldosterone system in liver cirrhosis -- 13. Renin-angiotensin-aldosterone system role in organ fibrosis -- 14. Role of renin angiotensin-aldosterone system in kidney homeostasis -- 15. Renin-angiotensin system in chronic kidney disease: Implications in stroke outcome -- 16. The renin-angiotensin system and cancer -- 17. Renin-angiotensin system and cancer: From laboratory to clinics -- 18. Role of renin-angiotensin system in cancer cachexia -- 19. Renin angiotensin system activity in different cancers: Mechanistic insight and preclinical studies -- 20. The new dimension of the renin-angiotensin system in the hallmarks of cancer -- 21. Renin-angiotensin system in hematological malignancies -- 22. Renin angiotensin system (RAS): The common thread between cancer and heart failure -- 23. Renin-angiotensin system: a potential therapeutic target for colorectal cancer -- 24. Anticancer role of natural phenolic acids by targeting angiotensin-converting enzyme (ACE) -- 25. Angiotensin-(1-7): A Prospective Cancer Therapeutic.
    Abstract: This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.
    Type of Medium: Online Resource
    Pages: XX, 498 p. 70 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031236211
    Series Statement: Advances in Biochemistry in Health and Disease, 25
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Biophysics. ; Biomechanics. ; Immunology. ; Bones. ; Biomedical engineering. ; Biomedical Research. ; Biophysics. ; Biomechanics. ; Osteoimmunology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Preface (Brianne K. Connizzo, Lin Han, Robert L. Sah) -- Scientific Impact -- Chapter 1. Aggrecan and Hyaluronan: The infamous Cartilage Polyelectrolytes- Then and Now (Anna Plaas, Meghan Moran, John Sandy, Vincent Hascall) -- Chapter 2. Understanding the Influence of Local Physical Stimuli on Chondrocyte Behavior (Byumsu Ki, Lawrence J. Bonassar) -- Chapter 3. Multiscale In Silico Modeling of Cartilage Injuries (Rami K. Korhonen, Atte S.A. Eskelinen, Gustavo A. Orozco, Amir Esrafilian, Cristina Florea, and Petri Tanska) -- Chapter 4. In Vitro Models and Proteomics in Osteoarthritis Research (Martin Rydén, Patrik Önnerfjord) -- Chapter 5. Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration (Chao Wang, Elizabeth R. Kahle, Lin Han) -- Chapter 6. Computational Modelling for Managing Pathways to Cartilage Failure (Saeed Miramini, David W. Smith, Bruce S. Gardiner, Lihai Zhang) -- Chapter 7. Gene Delivery to Chondrocytes (Christopher V. Nagelli, Christopher H. Evans, Rodolfo E. De la Vega) -- Chapter 8. Mechanical Articular Cartilage Injury Models and Their Relevance in Advancing Therapeutic Strategies (Bodo Kurz, Melanie L Hart, Bernd Rolauffs) -- Chapter 9. Hip Osteoarthritis: Bench to Bedside Perspective (Young-Jo Kim) -- Chapter 10. Harnessing Growth Factor Interactions to Optimize Articular Cartilage Repair (Stephen B. Trippel) -- Personal Tributes -- Index.
    Abstract: This is an open access book. In honor of his 75th birthday, we reflect on the impact of the pioneering work of Alan Grodzinsky and his laboratory. This volume includes in-depth discussions of tissue electromechanics, mechanobiology and biomechanics, and matrix biology in addition to the latest advancements in understanding the pathogenesis, progression and treatment of osteoarthritis. Unique to this volume, we overview decades of groundbreaking research that set the stage for the latest efforts in the field, highlighting the legacy of one researcher and their trainees.
    Type of Medium: Online Resource
    Pages: XIV, 173 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031255885
    Series Statement: Advances in Experimental Medicine and Biology, 1402
    DDC: 610.72
    Language: English
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    Keywords: Human physiology. ; Medicine Research. ; Biology Research. ; Cytology. ; Physiology. ; Human Physiology. ; Biomedical Research. ; Cell Biology. ; Physiology.
    Description / Table of Contents: Preface -- Chapter 1. Transcriptomics of the carotid body (Audrys G. Pauza, David Murphy and Julian F. R. Paton) -- Chapter 2. The adult carotid body: a germinal niche at the service of physiology (Ricardo Pardal) -- Chapter 3. Evidences that sympathetic overactivity and neurogenic hypertension correlate with changes in the respiratory pattern in rodent models of experimental hypoxia (Benedito H. Machado) -- Chapter 4. Control of arterial hypertension by the AhR blocker CH-223191: a chronopharmacological study in chronic intermittent hypoxia conditions (António B. Pimpão, Cátia Sousa, Maria J. Correia, Nuno R. Coelho, Emília Monteiro, António F. Melo Júnior and Sofia A. Pereira) -- Chapter 5. Three days of chronic intermittent hypoxia induces β1-adrenoceptor dependent increases in left ventricular contractility (Anthony L. Marullo, Eric F. Lucking, Daniel Pender, Pardeep Dhaliwal and Ken D. O’Halloran) -- Chapter 6. The beneficial effect of the blockade of stim-activated TRPC-ORAI channels on vascular remodeling and pulmonary hypertension inducedby intermittent hypoxia is independent of oxidative stress (Rodrigo Iturriaga and Sebastián Castillo-Galán) -- Chapter 7. Intermittent hypoxia and weight loss: insights into etiology of the sleep apnea phenotype (Marianne Gagnon, Stéphanie Fournier, François Marcouiller, Loralie Guay, Vincent Joseph, Natalie J Michael and Richard Kinkead) -- Chapter 8. Effects of gestational intermittent hypoxia on placental morphology andfetal development in a murine model of sleep apnea (Esther Valverde-Pérez, Jesús Prieto-Lloret, Elvira Gonzalez-Obeso, María I. Cabero, Maria L. Nieto, Marta I. Pablos, Ana Obeso, Angela Gomez-Niño, Rosa M. Cárdaba-García, Asunción Rocher and Elena Olea) -- Chapter 9. Ventilatory effects of acute intermittent hypoxia in conscious dystrophic mice (Michael N. Maxwell, Anthony L. Marullo, Aoife D. Slyne, Eric F. Lucking and Ken D. O’Halloran) -- Chapter 10. Intermittent hypoxia and diet-induced obesity on the intestinal wall morphology in a murine model of sleep apnoea (Esther Valverde-Pérez, Elena Olea, Ana Obeso, Jesús Prieto-Lloret, Asunción Rocher and Elvira Gonzalez-Obeso) -- Chapter 11. Enhanced peripheral chemoreflex drive is associated with cardiorespiratory disorders in mice with coronary heart disease (Liena Bravo, Katherin V. Pereyra, Hugo S. Diaz, Mariajosé Flores, Karla G. Schwarz, Camilo Toledo, Esteban Díaz-Jara, Leticia González, Marcelo E. Andia and Rodrigo Del Rio) -- Chapter 12. Role of peripheral chemoreceptors on enhanced central chemoreflex drive in non-ischemic heart failure (Katherin Pereyra, Esteban Díaz-Jara, Paulina Arias, Liena Bravo, Camilo Toledo, Karla Schwarz and Rodrigo Del Rio) -- Chapter 13. Effect of carotid body denervation on systemic endothelial function in a diabetic animal model (Marlene D. Cabral, Fátima O. Martins, Inês B. Martins, Bernardete F. Melo, Joana F. Sacramento, Silvia V. Conde and Jesus Prieto-Lloret) -- Chapter 14. Contribution of carotid bodies on pulmonary function during normoxia and acute hypoxia (Karla G. Schwarz, Maríajose Flores, Nicolas Voituron and Rodrigo Del Rio) -- Chapter 15. Increased abdominal perimeter differently affect respiratory function in men and women (Joana F. Sacramento, Iolanda Caires, Maria P. Guarino, Maria J. Ribeiro, João C. P. Santiago, Ana T. Timóteo, Mafalda Selas, Miguel Mota-Carmo and Silvia V. Conde) -- Chapter 16. Carotid body resection prevents short-term spatial memory decline in prediabetic rats without changing insulin signaling in the hippocampus and prefrontal cortex (Adriana M. Capucho, Ana Chegão, Fátima O. Martins, Bernardete F. Melo, Natália Madeira, Joana F. Sacramento, Rosalina Fonseca, Hugo Vicente Miranda and Sílvia V. Conde) -- Chapter 17. Constitutive Expression of Hif2a Confers Acute O2 Sensitivity to Carotid Body Glomus Cells (Olalla Colinas, Alejandro Moreno-Domínguez, Patricia Ortega-Sáenz and José López-Barneo) -- Chapter 18. Of mice and men, and plethysmography systems: does LKB1 determine the set point of carotid body chemosensitivity and the hypoxic ventilatory response? (A. Mark Evans) -- Chapter 19. Analyzing angiotensin II receptor type 1 clustering in PC12 cells in response to hypoxia using direct stochastic optical reconstruction microscopy (dSTORM) (Hayyaf S. Aldossary, Daniel J. Nieves, Deirdre M Kavanagh, Dylan Owen, Clare J Ray, Prem Kumar, Andrew M. Coney and Andrew P. Holmes) -- Chapter 20. The Carotid Body “Tripartite Synapse”: Role of Gliotransmission (The Carotid Body “Tripartite Synapse”: Role of Gliotransmission) -- Chapter 21. Necroptosis contributes to reduced carotid body-mediated chemoreflex function during aging in mice (Esteban Díaz-Jara, Karla G Schwarz, Angelica Ríos-Gallardo, Camilo Toledo, Julio A Alcayaga, Felipe A Court and Rodrigo Del Rio) -- Chapter 22. Chronic metformin administration does not alter carotid sinus nerve activity in control rats (Joana F. Sacramento, Bernardete F. Melo, Jesus Prieto-Lloret and Silvia V. Conde) -- Concluding remarks.
    Abstract: The book will contain reviews and brief research articles from the participants attending the International Society for Arterial Chemoreception (ISAC) meeting, to be held in Lisbon in Portugal in June/July 2020. Since ISAC was first established, almost 70 years ago, many advances in the classical field of arterial O2, CO2 and pH sensing have been achieved but the most impressive ones are probably related to the non-canonical roles of the carotid body, as its involvement in sympatho-mediated diseases. Over the recent years, the carotid body field has gained attention with the findings that carotid body dysfunction is associated with the development/maintenance of highly prevalent diseases from cardio-metabolic diseases to asthma. Knowing that most of the patients with these pathologies lack long-term disease control, it is imperative to define new pathophysiological mechanisms aiming to find new therapeutic targets for treatment and prevention. This book will cover a broad range of topics related, not only with the fundamental knowledge of the mechanisms related with the chemical sensing in the carotid body, but also with the adaptive and mal-adaptive responses of arterial chemoreceptors to O2-dependent and O2-independent mechanisms, namely with their impact on respiratory, cardiovascular, and metabolic homeostasis in healthy and disease conditions. This volume will be required text for all the researchers in the field of arterial chemoreceptors and will provide a valuable reference source for years to come.
    Type of Medium: Online Resource
    Pages: XIX, 210 p. 72 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031323713
    Series Statement: Advances in Experimental Medicine and Biology, 1427
    DDC: 612
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. Lysine demethylation in pathogenesis -- Chapter 2. Targeting the LSD1/KDM1 Family of Lysine Demethylases in Cancer and Other Human Diseases -- Chapter 3. KDM2 demethylases as drug targets -- Chapter 4. Role of histone demethylase KDM3 (JMJD1) in transcriptional regulation and cancer progression -- Chapter 5. KDM4 demethylases as drug targets -- Chapter 6. KDM5 lysine demethylases in pathogenesis, from basic science discovery to the clinic -- Chapter 7. Context-dependent functions of lysine demethylases in physiology and disease -- Chapter 8. KDM7 demethylases as drug targets.
    Abstract: This book provides a comprehensive summary of our current knowledge on lysine demethylases, a class of epigenetic regulators. It takes the reader on an exciting journey spanning the past two decades, starting from the initial discovery and characterization of these enzymes and leading up to the development of their small molecule modulators. These modulators have shown promise in clinical trials and hold great potential to improve patient outcomes. The book captures the progress made in this field and highlights the significant advancements that have paved the way for potential therapeutic applications. The book covers a wide range of topics, spanning both basic biology and clinical implications associated with lysine demethylases. It offers a comprehensive historical and conceptual framework for the discovery and characterization of similar epigenetic enzymes or modulators. Chapter one serves as an introductory overview, providing insights into the general characteristics and functions of lysine demethylases. In subsequent chapters, specifically chapters two to eight, each major family of lysine demethylases is individually explored in depth. By providing in-depth insights into the functional aspects of these enzymes, the book allows readers to grasp their significance in regulating cellular processes and influencing pathogenesis. Moreover, the book goes beyond fundamental knowledge and also explores the development of diagnostic and therapeutic strategies related to lysine demethylases. It highlights the potential for utilizing these enzymes as therapeutic targets for the treatment of various diseases, including cancer and infectious diseases. Additionally, the book highlights future directions aimed at further unraveling the roles of lysine demethylases and translating these findings into the clinic.
    Type of Medium: Online Resource
    Pages: VII, 184 p. 35 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031381768
    Series Statement: Advances in Experimental Medicine and Biology, 1433
    DDC: 610.72
    Language: English
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    Keywords: Medicine, Preventive. ; Health promotion. ; Biochemical markers. ; Medicine Research. ; Biology Research. ; Health Promotion and Disease Prevention. ; Biomarkers. ; Biomedical Research. ; Translational Research.
    Description / Table of Contents: Preface -- 1. PPPM innovation in primary, secondary, and tertiary care -- 2. Suboptimal Health Innovation: From Bench to Bedside -- 3. What is the routine mitochondrial health check-up good for? A holistic approch in the framework of 3P nedicine -- 4. Prehabilitation as an integral procedure in predictive, preventive, and personalized medicine and modern and effective healthcare -- 5. Pathophysiology of the acute pain chronification and the possibilities of its prediction and prevention -- 6. Prevention and prediction of body posture defects in children aged 5-6 years -- 7. A powerful paradigm: Predictive, preventive, and personalized medicine with multiomics of human pituitary adenomas -- 8. Critical Role of Telemedicine as a Platform for Preventive, Predictive and Personalized Diabetes Care During the COVID-19 Pandemics -- 9. Gut microbiome and liver dieases from the perspective of 3PM – the predictive, preventive, and personalized medicine -- 10. Computer–Aided Breast Cancer Classification Framework for Predictive, Preventive, and Personalized Medicine -- 11. Preventive and Personalized Strategies in Ambulatory and Clinical Cardiac Electrophysiology -- 12. Wound healing from bench to bedside: a PPPM bridge between physical therapies and chronic inflammation -- 13. Advantages of thermovision imaging for PPPM approach to diabetic foot -- 14. Predictive, Preventive and Personalized approach in Sleep Medicine -- 15. Chronic mental disorders - limitations and perspectives of prediction, prevention, diagnosis and personalized treatment in psychiatry -- 16. Development of artificial intelligence algorithms to analyse weather conditions for the prediction of cerebrovascular accidents -- 17. Periodontal health status is pivotal for an effective disease prediction, targeted prevention and personalised treatments of associated pathologies -- 18. Does the evaluation of ocular blood supply play a role in glaucoma diagnostics and prognosis of progression? -- 19. Wearable Revolution: Predictive, Preventive, Personalized Medicine (PPPM) Par Excellence.
    Abstract: This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics. In a long-term way, a significantly improved healthcare economy is one of the clear benefits of the proposed paradigm shift; a tight collaboration between all stakeholders including scientific community, healthcare providers, patient organisations, policy-makers and educators is analysed for the smooth implementation of the 3PM concepts. Further issues linked to big data management and medical ethics have to be carefully treated in the context of application of artificial intelligence in medicine.
    Type of Medium: Online Resource
    Pages: XIII, 348 p. 59 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031348846
    Series Statement: Advances in Predictive, Preventive and Personalised Medicine, 17
    DDC: 613
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cardiovascular system. ; Physiology. ; Biophysics. ; Cell interaction. ; Medicine Research. ; Biology Research. ; Regenerative medicine. ; Cardiovascular Physiology. ; Mechanobiological Cell Signaling. ; Biomedical Research. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Foreword -- Cardiac mechanoperception and mechanotransduction - Mechanisms of stretch sensing in cardiomyocytes and implications for cardiomyopathy -- Mechanotransduction in heart development -- Mechanobiology of cardiac growth in health and disease -- The role of mechanosensitive signaling cascades in repair and fibrotic remodeling of the infarcted heart -- Mechanobiology of cardiac fibroblasts in cardiac remodelling -- Mechanobiology of cardiac remodelling in cardiomyopathy -- Biophysical Stretch Induced Differentiation and Maturation of Induced Pluripotent Stem Cell-derived Cardiomyocytes -- Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration -- Mechanobiology of Exercise-Induced Cardiac Remodeling in Health and Disease -- Cardiac microvascular endothelial cells and pressure overload-induced cardiac fibrosis -- Cellular and Subcellular Mechanisms of Ventricular Mechano-Arrhythmogenesis -- Computational biomechanics of ventricular dyssynchrony and resynchronization therapy -- Therapeutic innovations for heart failure.
    Abstract: This book presents the latest findings in the field of cardiac mechanobiology in health and disease. Cardiac mechanobiology provides knowledge of all aspects of mechanobiology of the heart. Cardiomyogenesis is discussed as well as the mechanobiology of cardiac remodeling and regeneration. The molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes are explained, as well as stretch induced differentiation of cardiomyocytes derived from induced pluripotent stem cells. This volume of the series Cardiac and Vascular Biology complements the volume Vascular Mechanobiology in Physiology and Disease (volume 8) published in this series. The book is aimed at clinicians as well as researchers in cardiovascular biology, bioengineering and biophysics, and also represents an educational resource for young researchers and students in these fields.
    Type of Medium: Online Resource
    Pages: VIII, 353 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031239656
    Series Statement: Cardiac and Vascular Biology, 9
    DDC: 573.1
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Drug delivery systems. ; Pharmaceutical chemistry. ; Pharmacology. ; Medicine Research. ; Biology Research. ; Drug Delivery. ; Pharmaceutics. ; Pharmacology. ; Biomedical Research.
    Description / Table of Contents: Part 1: Patient-Centric Considerations.-Medicine Optimisation in Older -- Acceptability of drug formulations in older patients and effect on patient adherence -- Geriatric biopharmaceutics -- Excipient safety in older adults -- Part 2: Pharmaceutical Formulations Development for older Patients -- Oral and oromucosal formulation development and in vitro characterisation – patient-centric approaches for older adults -- Pulmonary drug delivery systems for older people -- Transdermal drug delivery systems for older patients -- Part 3 :Advanced Drug Delivery Systems for Older Patients -- Advanced oral drug delivery systems for older patients -- The ageing microbiome, pharmaceutical considerations and therapeutic opportunities -- Application of 3D printing in geriatric medicines, -- Application of electrospraying and advanced fabrication methods in geriatric medicines -- Vaccine development for older patients.
    Abstract: Pharmaceutical formulation design affects patient acceptability/adherence and pharmacokinetics of the drug. This is particularly important for older patients because of the physiological changes due to ageing and clinical/social circumstances related to medicine taking. This book provides a comprehensive review in the design of formulations to meet the needs of older patients. An overview of the key clinical, social and pharmaceutical factors affecting medication optimization, safety and acceptability in older adults is included, followed by patient-centric considerations including regulatory requirements, dosage form design and human factor studies. Advanced pharmaceutical technologies are discussed for their potential use in older adults such as 3D printing, long-acting oral formulations and novel vaccine technologies. The unique focus of the book will be of interest to pharmaceutical scientists in both industry and academia in searching for better formulations for older patients.
    Type of Medium: Online Resource
    Pages: XIII, 288 p. 63 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031358111
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 51
    DDC: 615.6
    Language: English
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    Keywords: Veterinary medicine. ; Animal welfare Moral and ethical aspects. ; Medicine Research. ; Biology Research. ; Animal culture. ; Neurosciences. ; Veterinary Science. ; Animal Ethics. ; Biomedical Research. ; Animal Science. ; Neuroscience.
    Description / Table of Contents: Part 1: History of Nonhuman Primates in Captivity and Primate Welfare in different Settings -- Chapter 1: The History of Primates in Zoos -- Chapter 2: The History of Chimpanzees in Biomedical Research -- Chapter 3: Using Primates in Captivity: Research, Conservation, and Education -- Chapter 4: The Welfare of Primates in Zoo -- Chapter 5: Welfare of Primates in Laboratories: Opportunities for Improvement.– Chapter 6: The Welfare of Primates Kept as Pets and Entertainers -- Chapter 7: Primates Under Human Care in Developing Countries: Examples from Latin America -- Part 2: Assessing Nonhuman Primate Welfare -- Chapter 8: Using Behavior to Assess Primate Welfare -- Chapter 9: Cognitive Bias Tasks: A New Set of Approaches to Assess Welfare in Nonhuman Primates -- Chapter 10: Physiological Measures of Welfare -- Chapter 11: Questionnaires and Their Use in Primate Welfare -- Part 3: Nonhuman Primate Housing and Husbandry -- Chapter 12: Meeting Cognitive, Behavioral, and Social Needs of Primates in Captivity -- Chapter 13: Primate Breeding Colonies: Colony Management and Welfare -- Chapter 14: Common Husbandry, Housing, and Animal Care Practices -- Chapter 15: Housing and Husbandry for Primates in Zoos -- Chapter 16: Humane End Points and End of Life in Primates Used in Laboratories -- Part 4: Individual Differences, Application, and Improvement of Nonhuman Primate Welfare -- Chapter 17: Primate Personality and Welfare -- Chapter 18: Sociality, Health, and Welfare in Nonhuman Primates -- Chapter 19: Benefits of Improving Welfare in Captive Primates -- Chapter 20: Enrichment -- Chapter 21: Challenging Cognitive Enrichment: Examples from Caring for the Chimpanzees in the Kumamoto Sanctuary, Japan and Bossou, Guinea -- Chapter 22: Training Research Primates -- Part 5: Biomedical Research, Ethics, and Legislation surrounding Nonhuman Primate Welfare -- Chapter 23: Arguments Against Using Nonhuman Primates in Research -- Chapter 24: The Indispensable Contribution of Nonhuman Primates to Biomedical Research -- Chapter 25: An unexpected symbiosis of animal welfare and clinical relevance in a refined nonhuman primate model of human autoimmune disease -- Chapter 26: Animal Welfare, Animal Rights, and a Sanctuary Ethos -- Chapter 27: The Welfare Impact of Regulations, Policies, Guidelines and Directives and Nonhuman Primate Welfare.
    Abstract: This volume reviews the broad topic of welfare in nonhuman primates under human care. Chapters detail the history of primates in captivity, ethical and legal issues surrounding the use of nonhuman primates as entertainment or in research, the different approaches that welfare are measured, and how housing, enrichment, and other conditions can foster or degrade welfare. Since humans began keeping nonhuman primates we have made vast strides in understanding their cognitive abilities, strong social bonds, vibrant personalities, and their capacity for joy and suffering. With an increasing number of countries banning the use of great apes in biomedical research, the welfare of primates in zoos and research facilities has gained increasing attention. This interdisciplinary work features contributors from many of the fields involved and those on both sides of the issue, thus providing an exhaustive overview of primate welfare. Readers from animal welfare science, primatology, animal testing, veterinary medicine, conservation to ethics and legislation will find this an important account.
    Type of Medium: Online Resource
    Pages: XIII, 671 p. 80 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030827083
    DDC: 636.089
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biology Technique. ; Animal welfare Moral and ethical aspects. ; Medicine Research. ; Biology Research. ; Experimental Organisms. ; Animal Ethics. ; Biomedical Research.
    Description / Table of Contents: Introduction -- Critique -- The Ideal Study -- What Can Go Wrong? -- Does It Really Go Wrong? -- The Consequences -- Construction -- Summary and Conclusions.
    Abstract: This book examines animal research conducted with the goal of medical translation to humans. It is written by Dr. Bradley Weiner, a surgeon who is active at a high level clinically and in biomedical research. After documenting that the vast majority of biomedical animal research fails to result in benefits to humans via translation, the book examines the sources of such failure; including the failure to justify the use of animals, the failure to properly apply scientific methods, the failure to perform the research properly in the lab, the failure to consider the possibility of translation a priori, and systematic sources of failure built into the biomedical research enterprise. The book then explores options to improve the situation, for the benefit of both the animals and humans.
    Type of Medium: Online Resource
    Pages: XIII, 62 p. 2 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031246777
    DDC: 570.28
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Blockchains (Databases). ; Medical care. ; Medical Ethics. ; Medical policy. ; Biomedical Research. ; Blockchain. ; Health Care. ; Medical Ethics. ; Health Policy.
    Description / Table of Contents: 1. Introductory chapter: Early applications and evolution of blockchain implementations in medicine -- 2. Can Blockchain Technology Change Contemporary Medicine As It Is Currently Understood? -- 3. The Current State of Healthcare Information Exchange (HIE) and Proposing a Blockchain HIE Infrastructure -- 4. An amalgamation of blockchain and connected health for combating COVID-19 -- 5. Applications of Blockchain Technology in the COVID-19 Era. 6. Distributed Ledgers and Immunity Passports: The Intersection of Clinical Medicine and Digital Technology -- 7. Digital Identity, Computational Reliabilism, and the Future of IOMT: Epistemic Reasoning and The Role of Blockchain in Removing Human Tampering from Pharmacovigilance Decision Making -- 8. Potential implementations of blockchain technology in patient safety: A high-level overview -- 9. Blockchain in Medical Education -- 10. Blockchain in Education: Linking Competency Assessment with Credentialing -- 11. Optimizing Blockchain Technology in Academic Medicine -- 12. Distributed Research Networks -- 13. Use of Blockchain Technology for Implantable Medical Device Tracking -- 14. Application of Blockchain Technology in Healthcare Supply Chains.
    Abstract: Blockchain technology (BT) is quietly transforming the world, from financial infrastructure, to the internet-of-things, to healthcare applications. With increasing penetration of BT into various areas of our daily lives, the need arises for better awareness and greater knowledge about the capabilities, benefits, risks, and alternatives to distributed ledger applications. It is hoped that current book will be one of the pioneering collections focusing on blockchain implementations in the area of healthcare, with specific aim to present content in an easy-to-understand and readily accessible way for typical end-users of blockchain-based applications. There are important areas within the fabric of modern healthcare that stand to benefit from implementations of BT. These areas include electronic medical records, quality control, patient safety, finance, device tracking, biostamping/biocertification, redundant storage of critical data, health and liability insurance, medication utilization tracking (including opioid and antibiotic misuse), financial transactions, academics/education, asset tokenization, public health and pandemics, healthcare provider credentialing, and many other potential applications. The ultimate goal of the proposed book would be to provide an integrative, easy-to-understand, and comprehensive picture of the current state of blockchain use in healthcare while actively engaging the reader in a forward-looking, exploratory approach toward future developments in this space. To accomplish this goal, an expert panel of contributors has been assembled, featuring scholars from top global universities and think-tanks.
    Type of Medium: Online Resource
    Pages: VIII, 250 p. 33 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031145919
    Series Statement: Integrated Science, 10
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Measurement. ; Measuring instruments. ; Biophysics. ; Biomedical Research. ; Measurement Science and Instrumentation. ; Biophysics.
    Description / Table of Contents: 1. Principles of molecular recognition -- 2. Theoretical Aspects -- 3. Molecular Recognition Units in Sensor Constructions -- 4. Binding blocks and Interfaces Designed for Sensing -- 5. Probing the properties of continuous media and interfaces -- 6. Detection of Ions and Low-molecular Targets -- 7. Detection of Biological Macromolecules and Recognition of harmful microbes -- 8. Sensing Inside the Living Cells -- 9. Ex-vivo Clinical Diagnostics -- 10. Imaging in vivo -- 11. Theranostics: Combining Targeting, Imaging and Therapy -- 12. Opening new horizons.
    Abstract: Fluorescence is the most popular technique in chemical and biological sensing because of its ultimate sensitivity, high temporal and spatial resolution and versatility that enables imaging within the living cells. It develops rapidly in the directions of constructing new molecular recognition units, new fluorescence reporters and in improving sensitivity of response up to detection of single molecules. Its application areas range from control of industrial processes to environment monitoring and clinical diagnostics. This book provides systematic knowledge of basic principles in design of fluorescence sensing and imaging techniques together with critical analysis of recent developments. Being a guide for students and young researchers, it also addresses professionals involved in active basic and applied research. Making a strong link between education, research and product development, this book discusses prospects for future progress.
    Type of Medium: Online Resource
    Pages: XXI, 761 p. 290 illus., 260 illus. in color. , online resource.
    Edition: 3rd ed. 2023.
    ISBN: 9783031190896
    DDC: 610.72
    Language: English
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    Keywords: Pharmacy. ; Medicine Research. ; Biology Research. ; Biochemistry. ; Botany. ; Biotechnology. ; Pharmacy. ; Biomedical Research. ; Biological Chemistry. ; Plant Science. ; Biotechnology.
    Description / Table of Contents: Foreword -- Acknowledgement -- Chapter I. DEVELOPMENTS IN KNOWLEDGE OF PLANT DERIVED NATURAL PRODUCTS PHARMACOGNOSY IN THE 21ST CENTURY -- Chapter II. QUALITY REQUIREMENTS FOR HERBAL DRUGS; ANALYTICAL METHODS -- Chapter III. BIOSYNTHESIS OF PLANT SUBSTANCES; BIOGENETIC RELATIONSHIPS -- Chapter IV. DISCUSSION OF HERBAL DRUGS BASED ON THE BIOGENETIC CLASSIFICATION OF THEIR MAIN ACTIVE COMPONENTS -- Chapter V. BIOLOGICAL ACTIVITY OF COMPOUNDS OF PLANT ORIGIN -- Chapter VI. PLANT BIOTECHNOLOGY -- Chapter VII. APPENDIX -- Abbreviations.
    Abstract: This book is at once heavy and light, comprehensive and extensive, conservative and modern. A broad spectrum of pharmacognosy is presented in a uniquely holistic manner. Numerous color photographs, didactic illustrations, and precise descriptions introduce the herbs found not only in Europe but throughout the world, showing the uses of herbs, their active ingredients, and the chemical structures and biosynthesis of biologically active molecules with beneficial and harmful effects. This excellent, well-presented encyclopedia on medicinal plants also includes descriptions of analytical and structural research and biotechnological methodology. Herbs and active molecules are classified according to the current biogenetic system. Designed for the professional education and training of students, pharmacists, physicians, and chemists, it is equally aimed at a broader scientific audience interested in botany and the analytical chemistry and biochemistry of natural products. .
    Type of Medium: Online Resource
    Pages: XVII, 570 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031173011
    DDC: 615.1
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Clinical medicine Research. ; Medical sciences. ; Drug development. ; Bioethics. ; Medical Ethics. ; Biomedical Research. ; Clinical Research. ; Preclinical Research. ; Bioethics. ; Medical Ethics.
    Description / Table of Contents: Chap 1. Research Environment -- Chap 2. Training, Supervision and Mentoring -- Chap 3. Research Procedures -- Chap 4. Safeguards -- Chap 5. Data Practices and Management -- Chap 6. Collaborative Working -- Chap 7. Publication and Dissemination -- Chap 8. Reviewing, Evaluating and Editing -- Chap 9. How to deal with allegations of misconduct.
    Abstract: This Open Access book is a guide to good, responsible research at each step of the process of research discovery, so that a researcher at the beginning of a scientific career has a clear pathway to doing good research and producing reliable results. The textbook will give context to the practices described in the European Code of Conduct for Research Integrity, guided by the fundamental principles or research integrity – reliability, honesty, respect, and accountability. The chapters in the book follow the good practices outlined in the Code, give practical advice and address basic principles. In this way, the book is applicable to different research fields. It directs readers to various sources for further and updated information, particularly drawing from the resources available at The Embassy of Good Science, the European platform for research integrity and ethics.
    Type of Medium: Online Resource
    Pages: XIII, 135 p. 13 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031224126
    Series Statement: Collaborative Bioethics, 1
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Developmental biology. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Cell Biology. ; Developmental Biology and Stem Cells. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research.
    Description / Table of Contents: Chapter 1: Biochemistry of hyaluronan synthesis -- Chapter 2: Update on hyaluronan in development -- Chapter 3: Long non-coding RNAs and epigenetic regulation of hyaluronan synthesis -- Chapter 4: The hyaluronan-rich zones of plasma membrane protrusions and extracellular vesicles -- Chapter 5: Hyaluronan in Kidney Fibrosis -- Chapter 6: Inter-α-inhibitor proteins: A review of structure and function -- Chapter 7: CD44: Does CD44v6 adversely impact the prognosis of cancer patients? -- Chapter 8: The pharmacokinetics and pharmacodynamics of 4-methylumbelliferone and its glucuronide metabolite in mice -- Chapter 9: The role of hyaluronan in skin wound healing -- Chapter 10: Sulfated hyaluronan: a novel player in cancer therapeutic and bioengineering approaches.
    Abstract: This book addresses the structural and biological properties of the extracellular matrix component and glycosaminoglycan polymer hyaluronan (or hyaluronic acid, HA). The book discusses various aspects of HA biology, e.g., HA synthesis and degradation, as well as the role of HA in embryogenesis, development, and cell maintenance. The reader will learn about the role of HA in different tissues as well as its biological activities triggered by the interaction with different HA receptors. A closer look is had at the involvement of HA in human pathologies such as cancer, kidney fibrosis and wound healing. Biotechnological and biomedical applications for HA such as scaffold generation and drug delivery, including the novel synthetic sulphated HA are explored. This work will appeal to a wide readership within the extracellular matrix and hyaluronan field. It can serve as an introduction to the field for junior scientists but can also help senior scientists to gain a broader view of the field beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: X, 215 p. 39 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031303005
    Series Statement: Biology of Extracellular Matrix, 14
    DDC: 571.6
    Language: English
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  • 53
    Keywords: Medicine Research. ; Biology Research. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. Introduction and History of Meningiomas -- Chapter 2. Clinical Presentation and Prognosis -- Chapter 3. Imaging Characteristics of Meningiomas -- Chapter 4. Histopathology of Meningiomas -- Chapter 5. Skull Base Meningiomas -- Chapter 6. Spinal Meningiomas -- Chapter 7. Surgical Therapies -- Chapter 8. Radiation Therapies -- Chapter 9. Illustrative Cases -- Chapter 10. Advances in CNS Tumor Classification -- Chapter 11. Genomic Landscape -- Chapter 12. Radiation-Induced Meningiomas -- Chapter 13. Meningioma Predisposing Syndromes -- Chapter 14. Epigentic Landscape -- Chapter 15. Immune Profile -- Chapter 16. PDX Models/Mouse Models/Cell Lines -- Chapter 17. Novel Medical Therapies -- Chapter 18. Quality of Life in Menigioma Patients -- Chapter 19. Illustrative Cases: Revisited with Adjuvant Molecular Data -- Chapter 20. Future Directions in Management.
    Abstract: "Meningiomas are tumors that originate from the arachnoidal cap cells of the leptomeninges. With an incidence rate of 8.36 per 100, 000 population, they are the most common primary central nervous system (CNS) tumors, accounting for a third of all cases. The World Health Organization (WHO) classification has traditionally categorized meningiomas into 15 different histopathological subtypes and three clinical grades. Tumors are classified as WHO grades 1, 2 or 3 based largely on histopathological features such as mitotic activity, presence of brain invasion, and other atypical features. However, there is increasing recognition of the limitations of histopathology including but not limited to: confounding factors such as sampling bias in a heterogeneous tumor, and technical factors related to the experience of the grading pathologist. Even with careful histologic grading, there remains significant variability in recurrence rates within each tumor grade. As more studies have uncovered the molecular features of meningiomas, novel biological alterations have helped refine classification schemes that more accurately reflect patient outcomes. This book reviews the current state of knowledge on the genomic and epigenomic landscape of meningiomas in order to identify the roles of genomic aberrations on diagnosis, prognosis, and treatment of meningiomas in addition to mainstays of surgical management, radiation therapy, and potential novel chemotherapies. Written by a team of world-renowned experts in neurosurgery, neuropathology, radiology, and radiation-oncology, this book is the definitive resource on meningioma management and investigation for both clinicians and scientists alike.".
    Type of Medium: Online Resource
    Pages: XVII, 255 p. 55 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031297502
    Series Statement: Advances in Experimental Medicine and Biology, 1416
    DDC: 610.72
    Language: English
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  • 54
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Biophysics. ; Medical physics. ; Signal processing. ; Bioinformatics. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Biophysics. ; Medical Physics. ; Signal, Speech and Image Processing . ; Bioinformatics.
    Description / Table of Contents: Preface -- Part I: Backscatter Coefficient methods -- Chapter 1. Quantitative Ultrasound: an Emerging Technology for Detecting, Diagnosing, Imaging, Evaluating, and Monitoring Disease (Ernie Feleppa) -- Chapter 2. Quantitative Ultrasound: Scattering theory (Michael Oelze) -- Chapter 3. Quantitative Ultrasound: Experimental implementation (Michael Oelze) -- Chapter 4. Extracting Quantitative Ultrasonic Parameters from the Backscatter Coefficient (Aiguo Han) -- Part II: Attenuation Estimation Methods -- Chapter 5. Attenuation Compensation and Estimation (Timothy Bigelow and Yassin Labyed) -- Chapter 6. Recent advances in attenuation estimation (Ivan Rosado Mendez) -- Part III: Envelope Statistics Methods -- Chapter 7. Review of envelope statistics models for quantitative ultrasound imaging and tissue characterization (Francois Destrempes and Guy Cloutier) -- Chapter 8. Information entropy and its applications (Po-Hsaing Tsui) -- Part IV: Ultrasound Computed Tomography -- Chapter 9. Ultrasound Tomography (Nicole Ruiter, Torsten Hopp, Michael Zapf and Hartmut Gemmek) -- Chapter 10. Full Wave Inversion and Inverse Scattering in Ultrasound Tomography/Volography (James Wiskin) -- Chapter 11. Clinical Importance of 3D Volography in Breast Imaging (John Klock) -- Part V: Acoustic microcopy -- Chapter 12. Acoustic Microscopy (Yoshifumi Saijo) -- Chapter 13. Advanced Topics in Quantitative Acoustic Microscopy (Cameron Hoerig and Jonathan Mamou) -- Part VI: Phantoms for Quantitative Ultrasound -- Chapter 14. Phantoms for Quantitative Ultrasound (Tim Stiles) -- Index.
    Abstract: Quantitative ultrasound (QUS) continues to mature as a research field and is primed to make a swift transition to routine preclinical and clinical applications. This book will serve two main purposes: Advanced education in QUS by providing a complete and thorough review of all theoretical, physical, and engineering aspects of QUS. Review of recent development of QUS by lead contributors in the research field. This 2nd edition will focus on 6 modern research topics related to quantitative ultrasound of soft tissues: Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc. Attenuation estimation for tissue characterization and improving spectral based methods Envelope statistics analysis as a means of quantifying and imaging tissue properties. Ultrasound computed tomography for preclinical and clinical imaging. Scanning acoustic microscopy for forming images of mechanical properties of soft tissues with micron resolution. Phantoms for quantitative ultrasound.
    Type of Medium: Online Resource
    Pages: X, 307 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031219870
    Series Statement: Advances in Experimental Medicine and Biology, 1403
    DDC: 610.72
    Language: English
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  • 55
    Keywords: Neurosciences. ; Neurochemistry. ; Medicine Research. ; Biology Research. ; Regenerative medicine. ; Neuroscience. ; Neurochemistry. ; Biomedical Research. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: The Purinergic Signaling: Overview -- Adenosine A2A Receptor-containing Heteromers and Neuroprotection -- Purinergic Signaling in Brain Physiology -- Neurotrophic Actions of Adenosine and Guanosine: Implications for Neural Development and Regeneration? -- Purinergic Signaling in Neurogenesis and Neural Fate Determination: Current Knowledge and Future Challenges -- Purinergic Signaling in Autism Spectrum Disorder -- Purinergic Signaling in Depression -- Roles of Purinergic Receptors in Alzheimer's Disease -- Purinergic Signaling in Basal Ganglia Diseases: Parkinson's Disease -- A Step in the ALS Direction: Lessons from the Purinome -- Purinergic P2 Receptors in Epilepsy -- Purinergic Signaling in Neuroinflammation -- Purinergic Signaling in Brain Tumors -- Development of Purinergic Receptor Agonists and Antagonists -- Acupuncture for Counteracting P2X4 and P2X7 Receptor Involvement in Neuroinflammation.
    Abstract: This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine, act in neuronal transmission, control of synaptic activity, proliferation, differentiation and cell death regulation in the CNS. This book focuses on the participation of purinergic receptors and ectonucleotidases, degrading ATP into adenosine, in embryonic and adult neurogenesis in vitro and in vivo as well as in synaptic transmission and pathophysiology. Further, the chapters discuss varying brain diseases, including Parkinson’s, and Alzheimer’s disease, autism, mood disorders and epilepsy, as well as brain tumors, in the context of purinergic signaling and its clinical aspects. The development of purinergic receptor agonists is also an important issue of this book. This book provides a critical review of the current state of science and will be useful for both scientists and students who are or would like to get involved in this area. Furthermore, this book addresses neuroscientists, physician and professionals from the industry, who would like to update themselves in this exciting and rapidly growing field of neuroscience.
    Type of Medium: Online Resource
    Pages: X, 376 p. 34 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031269455
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biology Technique. ; Medicine Research. ; Biology Research. ; Surgery. ; Experimental Organisms. ; Biomedical Research. ; Biological Techniques. ; Surgery.
    Description / Table of Contents: Chapter 1 -- The Basics -- Chapter 2. Collecting Specimen and Harvesting Tissues -- Chapter 3. Drugs Administration -- Chapter 4. Surgical Principles -- Chapter 5. Vascular Surgery. .
    Abstract: This book fills the current void of academic writings on laboratory mouse operation, giving research scientists, graduate students, and laboratory technicians an authoritative textbook and definitive laboratory companion. It covers mouse anatomy, the handling of the mouse, anesthesia, drug administration, specimen collection, organ harvesting and daily laboratory skills as well as advanced micro-surgery techniques. Its detailed description of mouse anatomy corrects many inaccuracies and misconceptions in the literature. It provides a wealth of basic laboratory skills and numerous advanced surgical techniques. The step-by-step explanations, with extensive photographic images and videos, improve the current understanding and practice of laboratory mouse operations. This book lays the foundation of laboratory mouse operations by offering a clear understanding of the basic principles, updated anatomic studies, and providing invaluable practical tools. It serves a wide audience, including laboratory animal scientists, pharmaceutical science researchers, graduate students in these fields, micro surgeons, veterinarians, and laboratory technicians. .
    Type of Medium: Online Resource
    Pages: XVII, 1070 p. 3067 illus., 3039 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030745011
    DDC: 570.28
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Aging. ; Cytology. ; Circadian rhythms. ; Neurosciences. ; Medicine Research. ; Biology Research. ; Ageing. ; Cellular Circadian Rhythms. ; Neuroscience. ; Biomedical Research.
    Description / Table of Contents: Sleep and circadian clock : Novel players in health impacts and Aging -- Cells and circuits of the suprachiasmatic nucleus and the control of circadian behaviour and sleep -- Circadian roles in sleep -- Age-related decline in the central circadian clock -- Cellular clocks in senescent cells -- Optimum sleep for healthy aging.
    Abstract: This edited volume focuses on the interplay between sleep and circadian rhythms with health, aging and longevity. Sleep is absolutely important for human health and survival, as insufficient sleep is associated with a plethora of conditions, including the poor quality of life, onset of several diseases, and premature death. The sleep–wake cycle is an evolutionary conserved neurobiological phenomenon, and is a prominent manifestation of the biological clocks localised in the suprachiasmatic nucleus (SCN). Understanding bidirectional relationship between sleep and circadian rhythms is of utmost importance and urgency, especially in the context of modern lifestyle where sleep is often out of phase with the internal body clocks, social jetlag, artificial lights and so on. The 25 chapters by leading researchers and experts from 11 countries are arranged into seven sections: understanding sleep and clock interlink in health and longevity; sleep, aging and longevity; clock, aging and longevity; melatonin, sleep and clock; genetic regulation of sleep and clock; therapeutic interventions in sleep disorders and clock misalignment; and experimental models to study sleep and clocks in aging and longevity. This book is useful for advanced undergraduate and graduate students, and researchers, educators, and other biomedical professionals. .
    Type of Medium: Online Resource
    Pages: IX, 561 p. 125 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031224683
    Series Statement: Healthy Ageing and Longevity, 18
    DDC: 571.878
    Language: English
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  • 58
    Keywords: Parasitology. ; Public health. ; Medicine Research. ; Biology Research. ; Parasitology. ; Public Health. ; Biomedical Research.
    Description / Table of Contents: Chapter 1: Malaria Epidemiology in China: a Historical Review -- Chapter 2: A Fact Sheet on Malaria: Global Status and Significant Species -- Chapter 3: Malaria-free in China: A Story of more than 70 Years -- Chapter 4: Malaria Parasites: Species, Life Cycle and Morphology -- Chapter 5: Pathogenesis and Clinical Features of Malaria -- Chapter 6: Morphology of Malaria Parasites at the Erythrocytic Stage -- Chapter 7: Immunodiagonsis of Malaria -- Chapter 8: Molecular Basis of Malaria Pathogenesis -- Chapter 9: Artificial Intelligence and Deep Learning in Malaria Diagnosis -- Chapter 10: Current Treatments for Malaria -- Chapter 11: Artemisinin Resistance in the Malaria Parasite Plasmodium falciparum -- Chapter 12: Traditional Chinese Medicines for Malaria Therapy.
    Abstract: This volume provides cutting-edge research from malaria parasitology and records the success story of disease control in China. The country, which was certified malaria-free by the World Health Organization in 2021, looks back on 70 years of effort and fruitful combat history. Expert authors supply insights from Plasmodium morphology to the clinical picture of malaria, molecular and immunodiagnosis, as well as current treatment and resistance issues, making this book a valuable blueprint for further success stories. The present work makes a significant contribution to the Sustainable Development Goal (SDG) 3, Good Health and Well-Being, with the aim to end malaria epidemics by 2030. Practical details of malaria elimination tools and strategies are completed by chapters on artificial intelligence in diagnosis and also traditional Chinese medicines for therapy. All researchers involved in malaria control and elimination around the globe will benefit from the knowledge presented, including students, scientists, policy makers at various levels, and professionals in healthcare and antiparasitic drug discovery.
    Type of Medium: Online Resource
    Pages: V, 292 p. 140 illus., 135 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031329029
    Series Statement: Parasitology Research Monographs, 18
    DDC: 571.999
    Language: English
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  • 59
    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Biomedical engineering. ; Biotechnology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Introduction -- Part 1. History of UPE research -- Mitogenetic rays -- Oxidation, free-radicals and ultraweak luminescence -- Biophotons and the International Institute of Biophysics (IIB) -- Part 2. Physics of light and light research -- Physics of photon emission -- Chemiluminescence as a tool for free radical research -- Highly sensitive imaging and spectral analysis of UPE from biological systems and their application -- Part 3. Molecular mechnisms of UPE -- Free radicals in biology -- Ultraweak luminescence from aqueous systems -- Chemiluminescence in oxidation of hydrocarbons: mechanistic fundamentals -- Chemiluminescence in oxidation of fatty acids and lipids -- Chemiluminescence in protein oxidation -- Emitters of endogenous biological chemiluminescence: quantum chemical modeling insights -- Enzymatic sources of free radicals -- Part 4. UPE research in life science -- Luminescence of animal tissues and vegetable oils -- Ultraweak photon emission from human body in relation to anatomy and histology -- Chronobiological aspects of spontaneous ultra-weak photon emission in humans: Ultradian, circadian and infradian rhythms -- Autoluminescence in seedlings: applications -- Application potentiality of Delayed Luminescence in Medicine, Biology and Food Quality researches -- Part 5. Mitogenetic effect and related phenomena: unresolved problems of UPE -- Mitogenetic effect: preface -- Mitogenetic effect in biological systems -- Physical properties of mitogenetic radiation -- Secondary, degradation and necrobiotic radiation -- Mitogenetic research in medicine: radiation of blood and cancer diagnostics -- Part 6. Non-chemical distant interaction hypothesis - pro et contra -- Non-chemical distant interaction: preface -- The possible functions of electromagnetic cell communication -- Understanding of Fritz-Albert Popp’s biophoton theory from the viewpoint of a biologist -- Limits to the information transfer through UPE -- Quantum nonlocality and biological coherence -- Part 7. Perspectives -- Integrating ultraweak photon emission in mitochondrial research -- Selected biophysical methods for enhancing biological autoluminescence -- Upconverting nanoparticles as sources of singlet oxygen -- Upconverting nanoparticles as sources of singlet oxygen -- Delayed Luminescence as a tool to study the structures of systems of biological interest and their collective long-living excited states -- Index.
    Abstract: This book addresses the phenomenon of biological autoluminescence (also known as ultraweak photon emission, UPE, biochemiluminescence, or biophotons) and deals with a very broad spectrum of subjects, ranging from basic observational studies to molecular mechanisms, free-radical processes, physics of electron excitation and photon emission, as well as detection techniques. The chapter topics include UPE in plants, animals, and the human body; microorganisms and subcellular structures; and model systems, illustrating its high prevalence. Several sections of the book provide some backstory, with emphasis on methodology, unresolved questions, and existing controversies. The authors raise and discuss complex, potentially divisive aspects: Are there any reasons to assume the existence of non-chemical interaction in biological systems? Can research results in the field of mitogenetic radiation, delayed luminescence, and oxychemiluminescence of model systems, be correctly interpreted? What does the future hold for this area of research? Altogether, this publication gives the reader a thorough overview of biological autoluminescence (UPE, biophotonics) research, making it ideal for students and researchers who are new to the area as well as those who are specializing in it.
    Type of Medium: Online Resource
    Pages: XII, 521 p. 345 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031390784
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geology. ; Geophysics. ; Physical geography. ; Geology. ; Geophysics. ; Earth System Sciences.
    Abstract: The sixth volume of “Processes in GeoMedia”, connected to the Russian journal with the same name, publishes new results of theoretical and experimental studies of the processes occurring in the bowels of the earth, the ocean, and the atmosphere; particular attention is paid to geomechanical aspects of the production of hydrocarbons, including laboriously extracted oils, and to the ecological problems of the biosphere, the human impact on the environment, methods of geophysical research are within the range of the journal interests.
    Type of Medium: Online Resource
    Pages: X, 697 p. 311 illus., 192 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031165757
    Series Statement: Springer Geology,
    DDC: 551
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geomorphology. ; Geology. ; Sedimentology. ; Geomorphology. ; Geology. ; Sedimentology.
    Description / Table of Contents: Introduction -- Definitions and location -- Constrains of the base-level altitude -- Main spatial and temporal trends -- Degradation -- Aggradation -- The channel profile -- Controlling factors -- Knickpoints and Knickzones -- Knickpoint retreat as a transient response -- Knickpoint evolution -- Rates -- The Messinian base-level fall -- Morphological products -- Additional adjustments to base-level changes -- The equilibrium test -- Tributary junctions -- The regional approach: The Dead Sea area as a field laboratory.
    Abstract: Much of the final shaping of the global landscape is accomplished by incision of river networks. The base-level is a principle determinate controlling the global relief by processes of erosion and aggradation. In the populated world, entrenchments triggered by base-level changes may become devastating events, damaging agricultural lands, undercutting bridges and destroying roads. The aim of this book, as a chapter in fluviomorphology, is to present the base-level control when active in the continental interior, unrelated to marine base-level fluctuations along the continental margins nor to sequence stratigraphic tract models in Exxon sequence stratigraphic sense. The focus is on the morphology and the gross trends of the processes controlling channel evolution through transient signals initiated by base-level changes and communicated upstream through the drainage network. The book brings together principles and conclusions gained by field work, by laboratory studies and by models, based on the widely scattered literature. The chapters include presentation of different types of base-levels, discussing the constraints of their altitude, the degradation and aggradation responses, the temporal and spatial trends along the channel network, the controlling factors, the knickpoint transient retreat process and its rates. Special emphasis is given to the Dead Sea Rift following its extreme base-level conditions which make it a unique field laboratory. This book is relevant to students in earth sciences as well as to planners, hydrologists and engineers dealing with geomorphology and surface drainage.
    Type of Medium: Online Resource
    Pages: XV, 154 p. 74 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031249945
    DDC: 551.41
    Language: English
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  • 62
    Keywords: Earth sciences. ; Geographic information systems. ; Natural disasters. ; Geology. ; Environmental monitoring. ; Earth Sciences. ; Geographical Information System. ; Natural Hazards. ; Geology. ; Environmental Monitoring.
    Description / Table of Contents: Modern Methods of Rock Mass Characterisation and Rock Fall Monitoring: A Review -- Rock Mass Characterization and Rockfall Monitoring: Traditional Approaches -- Criteria of the Prehistoric Rock Avalanches Identification and Discrimination -- Stability Assessment of Markundi Hills Using Q-slope, SMR and Simulation Tools -- Geotechnical Investigation of Landslide in Ooty, India -- Geomechanical and Kinematic Stability Analysis of Unstable Slopes (near 9th km stone) on Palani – Kodaikkanal Ghat Section in Tamil Nadu -- Geological and Geotechnical Studies of Nungkao Landslide along Imphal-Jiribam National Highway, NH-37, Manipur, India -- Stability Assessment of Lateritic Soil Slope along NH-66, Ratnagiri Maharashtra, India -- Rockfall Hazard: A Comprehensive Review of Current Mitigation Practices -- Debris Flow Hazard in India: Current Status, Research Trends, and Emerging Challenges -- Early Warning System for Rainfall Induced Landslide – A Laboratory Prototype Model -- Study and Instrumental Monitoring of Landslides at the "Russkie Gorki" Site in the Mzymta River Valley, Sochi Region, Russia -- Application of Scoops3D and GIS for Assessing Landslide Hazard in Trung Chai Commune, Sapa, Vietnam -- Landslide Susceptibility Assessment using Frequency Ratio Model in Turung Mamring, South District of Sikkim, India -- Mapping of Annual Ground Displacement using Remote Sensing Methods for Critical Slopes along the Bhagirathi River in Uttarakhand, India -- Landslides Inventory of Active Ramgarh Thrust Zone through Image Processing and GIS Techniques in Sikkim, India -- Landslide Susceptibility Zonation Mapping using Frequency Ratio, Information Value Model, and Logistic Regression Model: A Case Study of Kohima District in Nagaland, India -- Unmanned Aerial Vehicles Technology for Slope Hazard Assessment, Monitoring, and Post Failure Management -- Landslide Hazard Assessment Using Machine Learning and GIS -- Social and Economic Impacts of Kotropi Landslide on National Highways of Himalayas – A Case Study. .
    Abstract: This book intends to decipher the knowledge in the advancement of understanding, detecting, predicting, and monitoring landslides. The number of massive landslides and the damages they cause has increased across the globe in recent times. It is one of the most devastating natural hazards that cause widespread damage to habitat on a local, regional, and global scale. International experts provide their experience in landslide research and practice to help stakeholders mitigate and predict potential landslides. The book comprises chapters on: Dynamics, mechanisms, and processes of landslides; Geological, geotechnical, hydrological, and geophysical modelling for landslides; Mapping and assessment of hazard, vulnerability, and risk associated with landslides; Monitoring and early warning of landslides; Application of remote sensing and GIS techniques in monitoring and assessment of landslides. The book will be of interest to researchers, practitioners, and decision-makers in adapting suitable modern techniques for landslide study.
    Type of Medium: Online Resource
    Pages: XXV, 419 p. 166 illus., 157 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031238598
    DDC: 550
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geodynamics. ; Geology. ; Petrology. ; Paleontology . ; Geodynamics. ; Geology. ; Petrology. ; Paleontology.
    Description / Table of Contents: Chapter 1. Overview Of The Pilbara Craton -- Chapter 2. Eoarchean And Early Paleoarchean Crust Of The Pilbara Craton -- Chapter 3. Warrawoona Large Igneous Province, 3530–3427 Ma -- Chapter 4. Strelley Pool Formation: Continental Sedimentation Between Paleoarchean Lips -- Chapter 5. Kelly Large Igneous Province, 3350–3315 Ma -- Chapter 6. Paleoarchean Continental Breakup Of The Pilbara Craton -- Chapter 7. Mesoarchean Rift And Marginal Basins Of The Pilbara Craton -- Chapter 8. Mesoarchean Subduction In The Pilbara Craton -- Chapter 9. Mesoarchean Basin Evolution Inland Of Magmatic Arcs -- Chapter 10. Orogenies, Cratonization And Post-Orogenic Granites -- Chapter 11. Mineralization In The Northern Pilbara -- Chapter 12. Fortescue Group: The Neoarchean Breakup Of The Pilbara Craton.
    Abstract: One of today’s major geoscientific controversies centres on the origin of the Archean granite‒greenstone terranes. Is the geology of these scattered remnants of our planet’s early crust consistent with the theory that modern-style plate-tectonic processes operated from the early Archean, or does it indicate that tectonic and magmatic processes were different in the Archean? Earth has clearly evolved since its initial formation, so at what stage did its processes of crustal growth first resemble those of today? The logical place to seek answers to these intriguing and important questions is within the best-preserved early Archean crust. The Pilbara region of northwest Australia is internationally famous for its abundant and exceptionally well-preserved fossil evidence of early life. However, until recently the area has received much less recognition for the key evidence it provides on early Archean crustal evolution. This book presents and interprets this evidence through a new stage-by-stage account of the development of the Pilbara’s geological record between 3.53 and 2.63 Ga. The Archean Pilbara crust represents one fragment of Earth’s oldest known supercontinent Vaalbara, which also included the Kaapvaal Craton of southern Africa. Recognition of Vaalbara expands the background database for both these areas, allowing us to more fully understand each of them. .
    Type of Medium: Online Resource
    Pages: XLV, 465 p. 144 illus., 118 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031180071
    Series Statement: Modern Approaches in Solid Earth Sciences, 24
    DDC: 551.1
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geology. ; Geochemistry. ; Sedimentology. ; Geology. ; Geochemistry. ; Sedimentology.
    Description / Table of Contents: Chapter1. Introduction of Field Geology -- Chapter2. Petrography -- Chapter3. Stratigraphy -- Chapter4. Geochemistry -- Chapter5. Sedimentalogy.
    Abstract: This book examines novel geological formations and lava flows of basaltic rock in India, and provides a comprehensive understanding of basaltic rock geology, petrography, stratigraphy and geochemistry. Readers are given insight into the geologic conditions of basaltic rock in central India, and a basic introduction to field geology methods and parameters in the study region. The author shows detailed petrographic and mineralogical characteristics of various basaltic rock formations, and identifies key features using major, trace and rare earth element stratigraphic analysis. An analysis of the sequence of hydro-geological formations of the basaltic rock area using ground water fluctuation models is also provided to assess surface and groundwater resources, which are important for planning development in the basaltic hard rock area. The book aims to be a resource for researchers, scientists, teachers and students interested in geology, petrography and geochemistry.
    Type of Medium: Online Resource
    Pages: XI, 256 p. 158 illus., 145 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031305740
    DDC: 551
    Language: English
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    Keywords: Geology. ; Sedimentology. ; Paleontology . ; Geodynamics. ; Geology. ; Sedimentology. ; Paleontology. ; Geodynamics.
    Description / Table of Contents: Chapter 1. Introduction and Back Ground History -- Chapter 2. The Ediacaran rock units -- Chapter 3. The Cambrian Period -- Chapter 4. The Ordovician Period -- Chapter 5. The Silurian Period -- Chapter 6. The Devonian Period -- Chapter 7. The Carboniferous Period -- Chapter 8. The Permian Period.
    Abstract: This book presents the following geological contributions in Ediacaran and Paleozoic rocks. 1) It introduces four new rock units for the first time, the Ediacaran El Urf Formation (volcanoclastic sediments in the central Eastern Desert), the Ediacaran Abu Haswa Formation (stromatolitic dolostone in southwestern Sinai), the Early Permian Wadi Dome Formation (mixed clastics and carbonates in the west of Suez Gulf) and the Early Permian Misawag Formation (in the subsurface, northwestern Desert), 2) making correlation of the Ediacaran rock units with the corresponding rock units in Libya, Jordan, Iraq and Saudi Arabia, 3) linking the exposed Paleozoic rock units with their equivalent rock units in subsurface in northwestern desert, 4) correlating the Paleozoic rock units with the equivalent rock units in adjacent countries, e. g. Libya, Jordan, Iraq and Saudi Arabia, 5) manifesting the possible depositional environments of the Ediacaran and Paleozoic rock units. Additionally, it offers an important unique geological information about the Ediacaran and Paleozoic rock units in Egypt. It unifies the nomenclature of Paleozoic rock units that take numerous names for the same geological time. It obsoletes the formation names that do not follow the rules of the North American stratigraphic code (1983) for rock units’ nomenclature. It provides the target audience illustrations, e.g. field photographs for the exposed rock units that save efforts and time for audience (undergraduate, post-graduate, researchers and professional) to reach to the original localities of each rock units. It provides the audience with schematic diagrams that exhibit the link between the exposed and subsurface rock units all over the Egyptian territory. It describes the following topics of each rock unit: definition, stratigraphic contact, lithological characteristics, faunal and floral associations that are used for the identification of the possible age, correlation with corresponding rock units in adjacent countries, e.g. Libya, Jordan, Iraq and Saudi Arabia and the possible depositional environments for each rock units. The book is a fundamental source of an updated version of the information in the field to the undergraduate, graduate, researchers, professional, practitioners and policy planning elsewhere.
    Type of Medium: Online Resource
    Pages: XVIII, 209 p. 113 illus., 112 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031273209
    Series Statement: Earth and Environmental Sciences Library,
    DDC: 551
    Language: English
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    Keywords: Geology. ; Geotechnical engineering. ; Geographic information systems. ; Geology. ; Geotechnical Engineering and Applied Earth Sciences. ; Geographical Information System.
    Description / Table of Contents: Part I: Terrestrial, Shipboard and Airborne Gravimetry -- Measurement of Absolute Gravity and Deflection of the Vertical at Sea -- Multi-scenario Evaluation of the Direct Method in Strapdown Airborne and Shipborne Gravimetry -- Improving Gravity Estimation Accuracy for the GT-2A Airborne Gravimeter Using Spline-Based Gravity Models -- Gravimetric Studies in the Sea of Japan -- About Identification of Instrument Error Parameters for a Gravity Gradiometer -- Numerical Model of Moving-Base Rotating Accelerometer Gravity Gradiometer -- New Algorithm for Gravity Vector Estimation from Airborne Data Using Spherical Scaling Functions -- Results of Astro-measurements of the Deflection of Vertical Using the New Observation Technique -- Observations with gPhone Gravimeter in Moscow -- Part II: Absolute Gravimetry -- On Uncertainties of Laser Interferometric Absolute Ballistic Gravimeters due to Magnetic Effects in the Free-Fall Gravity Measurements -- Evaluation of Systematic Errors in the Compact Absolute Gravimeter TAG-1 for Network Monitoring of Volcanic Activities -- Design of New Launch and Interferometer Systems for the IMGC-02 Absolute Gravimeter -- Twelve Years of High Frequency Absolute Gravity Measurements at the UK’s Space Geodesy Facility: Systematic Signals and Comparison with SLR Heights -- Part III: Relative Gravimetry and Applications -- Studying the Evolution of Resolution Capabilities and Approximation Accuracy of Global Models by Spectral Characteristics -- The Role of Non-tidal Atmospheric Loading in the Task of Gravity Field Estimation by Inter-satellite Measurements -- Formation of Self-consistent Navigational Gravity Maps of Local Areas and Joint Assessment of Their Navigation Quality -- Methods of Bistatic GNSS-radio Altimetry for Determining Height Profile of the Ocean and Their Experimental Verification -- Absolute and Relative Gravity Measurements at Volcanoes: Current State and New Developments Under the NEWTON-g Project -- The Effect of Measurement Preprocessing in the Gravity-Aided Navigation -- Sensitivity of Algorithms for Estimating the Gravity Disturbance Vector to Its Model Uncertainty.
    Abstract: This open access volume contains the proceedings of the 5th Symposium on Terrestrial Gravimetry: Static and Mobile Measurements (TG-SMM2019) held in St. Petersburg, Russia, October 1 – 4, 2019. The symposium was hosted by the State Research Center of the Russian Federation Concern CSRI Elektropribor, JSC and was attended by 75 participants from 15 different countries. 32 oral and 20 poster contributions were presented in four different topical sessions: Terrestrial, shipboard and airborne gravimetry, Absolute gravimetry, Relative gravimetry, gravity networks and applications of gravimetry and Cold atom and superconducting gravimeters, gravitational experiments.
    Type of Medium: Online Resource
    Pages: VIII, 160 p. 7 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031259029
    Series Statement: International Association of Geodesy Symposia, 153
    DDC: 551
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geology. ; Spectrum analysis. ; Crystallography. ; Geology. ; Spectroscopy. ; Crystallography and Scattering Methods.
    Description / Table of Contents: 1. Introduction -- 2. Basic concepts -- 3. The petrographic microscope: a polarized light microscope -- 4. Optical properties of minerals in plane polarized light (PPL) -- 5. Optical properties of minerals in cross polarized light (XPL) -- 6. Conoscopic observations and interference figures -- 7. Igneous rocks: Some basic concepts -- 8. Metamorphic rocks: Some basic concepts -- 9. The mineral plates and how to use them -- Appendix.
    Abstract: This book presents a guide of optical mineralogy for beginners and microscopists who need to brush up their knowledge. It allows the fast identification of common rock-forming minerals in a thin section using a polarized light microscope and transmitted plane and cross polarized light. The book summarizes essential principles of optical mineralogy in numerous schemes. It explains, with the aid of more than 1000 microscopic images, how to determine the diagnostic optical characteristics of a mineral in a thin section. Seventy-two mineral plates of sixty-five common rock-forming minerals comprising typical microscopic images in plane and cross polarized light illustrate the most important optical and crystallographic parameters and their diagnostic characteristics and typical appearance in various geological settings. The original approach of the book is to facilitate mineral identification by mineral plates organized according to color in transmitted plane polarized light and, in each color category, according to decreasing maximum birefringence in cross polarized light. In addition, two chapters are devoted to the classification of magmatic and metamorphic rocks and their common mineral parageneses and textures. The book reflects the author’s experience of teaching optical mineralogy in the most efficient way possible to generations of students at the Universities of Heidelberg (Germany), Basel (Switzerland), and Geneva (Switzerland).
    Type of Medium: Online Resource
    Pages: XIII, 278 p. 281 illus., 253 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031196126
    Series Statement: Springer Textbooks in Earth Sciences, Geography and Environment,
    DDC: 551
    Language: English
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    Keywords: Geology. ; Sedimentology. ; Geodynamics. ; Geology. ; Sedimentology. ; Geodynamics.
    Description / Table of Contents: The geological setting of the Moroccan High Atlas and its plate tectonics context -- Structure of the Central High Atlas (Morocco). Constraints from potential field data and 3D models -- Magnetic properties of the remagnetized carbonates of the Central High Atlas (Morocco) -- Paleomagnetism of the Central High Atlas. The widespread Cretaceous Remagnetization and structural implications -- Geodynamic evolution during the Mesozoic and Cenozoic in the Central High Atlas of Morocco from Anisotropy of Magnetic Susceptibility -- Kinematics of structures and basin evolution in the Central High Atlas. Constraints from AMS and paleomagnetic data.
    Abstract: This book presents a significant amount of structural, paleomagnetic and magnetic fabric data in the Central High Atlas (Morocco). The authors thoroughly described and analyzed the present-day structure of this intraplate chain through 22 of cross-sections, potential field data analysis and 3D reconstruction. In addition, the authors propose a palinspastic reconstruction of the structure of the basin at 100 Ma (i.e., post-extension and pre-compression) to finally evaluate its Mesozoic and Cenozoic geodynamic evolution. This books presents (1) a unique three-dimensional model at the chain scale, (2) an analysis of the ca. 100 Ma remagnetization, to perform palinspastic restorations of most representative structures, (3) as well as the interpretation of the magnetic fabrics in order to unravel the tectonic or deformation setting that the rocks underwent in different parts of the basin. This book is of interest to structural geologists in Northern Africa, the Mediterranean and Iberia, as well as to those interested in inverted intraplate basins and paleomagnetists from around the planet. Also, this book is intended to help students to understand better the geological evolution of the Atlas and therefore Morocco and surrounding areas.
    Type of Medium: Online Resource
    Pages: XXII, 646 p. 324 illus., 311 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031166938
    Series Statement: Springer Geology,
    DDC: 551
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geology. ; Mining engineering. ; Physical geography. ; Power resources. ; Environmental economics. ; Economic geography. ; Geology. ; Mining and Exploration. ; Physical Geography. ; Resource and Environmental Economics. ; Economic Geography.
    Description / Table of Contents: 1. Introduction: Early Years of Mining and Geology -- 2. Geological Survey for Jamaica -- 3. A Temporary Survey -- 4. The Bauxite Industry and its Development -- 5. The Modern Geological Survey -- 6. Transforming Jamaica’s Mining Sector.
    Abstract: Mining and geological survey work in Jamaica goes back several hundred years and was initiated by the Europeans when they colonized the Island. The year 2019 marked 160 years since the first Government-commissioned Geological Survey of Jamaica. This is one of the oldest survey activity of this type in the World! This book seeks to commemorate this heritage. It is one of the first books of its kind examining the evolution of the mineral sector and geological survey work of Jamaica, set in the framework of the Country's history of over 500 years. The Reader will explore a relatively unfamiliar side of the Country's development, linked to popular historical stories that shaped the Nation. The information presented are mostly documented in dated academic literature that are not gauged for a wide audience. This book however, aims to make this information accessible for a wider readership such as students, amateur scientist, non-professionals or anyone who wishes to learn about the rich history and heritage, and the contributions to national development from Europe and much later, North America.
    Type of Medium: Online Resource
    Pages: XVII, 158 p. 19 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031426049
    Series Statement: Historical Geography and Geosciences,
    DDC: 551
    Language: English
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    Keywords: Biogeography. ; Physical geography. ; Materials science. ; Medicine Research. ; Biology Research. ; Ecology . ; Biogeosciences. ; Earth System Sciences. ; Materials Science. ; Biomedical Research. ; Terrestial Ecology.
    Description / Table of Contents: Methods for studying the interactions in biogenic–abiogenic systems -- Geochemistry of biogenic-abiogenic systems -- Biomineralization and nature-like materials and technologies-Medical geology -- Organic mineralogy-Biomineral interactions in soil-Effect of microorganisms on natural and artificial materials -- Philosophical and historical aspects of interdisciplinary research.
    Abstract: The book represents a collection of papers presented at VII International Symposium "Biogenic - abiogenic interactions in natural and anthropogenic systems" that was held on 26-29 September 2022 in Saint Petersburg (Russia). Papers in this book cover a wide range of topics connecting with interactions between biogenic and abiogenic components in lithosphere, biosphere and technosphere. The main regarding topics are following: biomineralization in living organisms and nature-like materials; biomineralization in geosystems; geochemistry of biogenic-abiogenic systems; biomineral interactions in soil; interaction of microorganisms with natural and artificial materials; medical geology; philosophical aspects of interdisciplinary researchs.
    Type of Medium: Online Resource
    Pages: XIII, 675 p. 216 illus., 141 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031404702
    Series Statement: Springer Proceedings in Earth and Environmental Sciences,
    DDC: 578.09
    Language: English
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    Keywords: Paleontology . ; Geology. ; Science History. ; Paleontology. ; Geology. ; History of Science.
    Description / Table of Contents: Part I. Introduction. Chapter 1: Fossil Hunting in the Badlands of South Dakota -- Chapter 2: Harold Rollin Wanless and Researching the Badlands -- Part II. 1920 Expedition. Chapter 3: June 20 to June 26 - Chicago to Scenic -- Chapter 4: June 27 to June 29 - Freight Train to Interior -- Chapter 5: June 30 to July 3 - Collecting Fossil History at Cedar Pass and the Wall -- Chapter 6: July 4 to July 8 - White River and the Rain -- Chapter 7: July 9 to July 13 - Back to Scenic and Hart Table -- Chapter 8: July 14 to July 17: Finding the Giant Pig -- Chapter 9: July 18 to July 22 - Farmers, Fossils and Heat -- Chapter 10: July 23 to July 26 - Jerks and Gentlemen -- Chapter 11: July 27 to July 29 - The Past = The Key to the Present -- Chapter 12: July 30 - Nearly Trapped on Sheep Mountain -- Chapter 13: July 31 to August 3 - Collecting in Bear Creek Pocket -- Chapter 14: August 4 to 5 - Research Back up Sheep Mountain -- Chapter 15: August 7 to 9 - Wild Stallions & Broken Springs -- Chapter 16: August 10 to 12 - Golf Ball Hail and Fossil Dogs -- Chapter 17: August 13 to 15 - Sabre-Tooth Tigers -- Chapter 18: August 16 to 18 - Final photos and samples -- Chapter 19: August 19 to 22 - Shipping and Heading Home -- Part III – 1921 and 1922 Expeditions to the Badlands. Chapter 20: Summer 1921 Tackling the West in the Rachael Jane -- Chapter 21: Summer 1922 Completing an Ancient Story -- Part IV – Harold Rollin Wanless and the Badlands after the 1920s. Chapter 22: Harold’s Life and Science after 1922.
    Abstract: Through the original writings and photography of renowned geologist Harold Rollin Wanless, this book paints a thorough and engaging picture of the White River Badlands’ landscape, geology, biology, pioneer settlers, and how life was lived 100 years ago in a harsh, challenging, remote setting. In the summer of 1920, Harold Rollin Wanless, fresh from an undergraduate geology degree at Princeton, spent the first of three summers in the Badlands of South Dakota camping, hiking, and collecting fossil vertebrate skulls. Harold produced a fascinating and thorough diary and report, illustrated with over 100 image plates, in which he explains the geology, biology, and climate of this famous area. Wanless became deeply involved with and vividly records the life, hopes, trials and character of the new homesteading pioneers of the area, and the people and livelihoods he encountered are reflected in the diary as well. This is an engaging look at the history, environment, people and geological character of a unique portion of the American West. Combining a first-hand look at the White River Badlands and its people a century ago with the fossil history contained in its Cenozoic sediments gives a well-rounded historical presentation. This diary was found, compiled, and edited by Drs. Harold Rogers Wanless (the diarist’s son and an accomplished geologist himself) and Emmett Evanoff. In the introductory and concluding chapters of this book, they provide a broader perspective of Harold Rollin Wanless’s life and his significant achievements beyond the Badlands venture described here. In addition, this narrative - written “only” a century ago - provides a stark contrast with how we travel, communicate, conduct research and survive today, yet shows that human curiosity and kindnesses have not changed.
    Type of Medium: Online Resource
    Pages: XXVIII, 187 p. 104 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031251184
    DDC: 560
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geology. ; Geodynamics. ; Natural disasters. ; Geochemistry. ; Geology. ; Geodynamics. ; Natural Hazards. ; Geochemistry.
    Description / Table of Contents: El Hierro Island Volcanological Science: An Overview -- Past, Present and Future Volcanic Activity on El Hierro -- Review of Submarine Eruptions in El Hierro Prior to Tagoro -- From Magma Source to Volcanic Sink Under Tagoro Volcano (El Hierro, Canary Islands): Petrologic, Geochemical and Physiographic Evolution of the 2011-2012 Submarine Eruption -- Magma Storage and Migration in El Hierro During the Period 2011-2014 -- Geophysical, Geodetic and Geochemical Evidence for Precursory Activity: The 2011-2012 Tagoro Submarine Eruption -- Geomorphology of Tagoro Volcano Along Eruptive and Posteruptive Phases -- Ten Years of Intense Physical-chemical, Geological and Biological Monitoring Over the Tagoro Submarine Volcano Marine Ecosystem (Eruptive and Degassing Stages) -- Tagoro Submarine Volcano as a Natural Source of Significant Dissolved Inorganic Nutrients -- Microbial Communities Surrounding an Underwater Volcano near the Island of El Hierro (Canary Islands) -- Impact of Tagoro Volcano Formation on Benthic Habitats and Asscociated Biota: A Review -- Identification and Management of Indirect Volcanic Risks: Citizens’ Rockfall Observatory on the Island of El Hierro -- Tagoro, the Youngest Submarine Volcano in the Spanish Geoheritage Inventory: Scientific Value, Geoconservation and Opportunities for Geotourism.
    Abstract: This book presents an in-depth review of El Hierro Island, the youngest and most southwesterly volcano of the Canary Islands. In October 2011, a submarine eruption started offshore El Hierro Island. The 2011–2012 El Hierro eruption has probably been the best monitored and studied submarine eruption to date and has sparked interest in the study of this young ocean island volcano. During the last decade, multidisciplinary investigations, e.g., on the geological and volcanological character of its past and latest onshore and offshore eruptions, the geophysical and geochemical signatures of its magmatic plumbing system structure and dynamics, as well as the bio-geophysical interactions and consequences of submarine eruptions in the ocean, have been conducted. This book provides an authoritative review of many of these scientific advances as well as multiple remaining unknowns for the study of El Hierro Island and its 2011–2012 submarine eruption. Such knowledge should be of great interest to specialists not only in the Canary Islands volcanism but also in similar ocean island intraplate volcanoes.
    Type of Medium: Online Resource
    Pages: XI, 272 p. 82 illus., 81 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031351358
    Series Statement: Active Volcanoes of the World,
    DDC: 551
    Language: English
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    Keywords: Physical geography. ; Machine learning. ; Geology. ; Natural disasters. ; Earth System Sciences. ; Statistical Learning. ; Geology. ; Natural Hazards.
    Description / Table of Contents: Chapter1-Intelligent methods and motivations to use in volcanology and seismology -- Chapter2-Machine Learning: The concepts -- Chapter 3 - Machine Learning Applications in volcanology and seismology -- Chapter 4 - Deep Learning: The concepts -- Chapter 5:Deep Learning: Applications in Seismology and Volcanology -- Chapter 6: Evolutionary Algorithms with focus on Genetic Algorithm -- Chapter 7: Application of Genetic Algorithm in volcanology and seismology.
    Abstract: This book presents intelligent methods like neural, neuro-fuzzy, machine learning, deep learning and metaheuristic methods and their applications in both volcanology and seismology. The complex system of volcanoes and also earthquakes is a big challenge to identify their behavior using available models, which motivates scientists to apply non-model based methods. As there are lots of seismology and volcanology data sets, i.e., the local and global networks, one solution is using intelligent methods in which data-based algorithms are used. .
    Type of Medium: Online Resource
    Pages: XVII, 203 p. 219 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031154324
    Series Statement: Advances in Volcanology, An Official Book Series of the International Association of Volcanology and Chemistry of the Earth’s Interior,
    DDC: 550
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Petrology. ; Mineralogy. ; Geology. ; Petrology. ; Mineralogy. ; Geology.
    Description / Table of Contents: 1 Introduction to Metamorphic Rocks, Rock Metamorphism, and Metamorphic Processes -- Metamorphic Rocks -- 3 Metamorphic Processes -- 4 Metamorphic Grade, conditions of metamorphism -- 5 Metamorphism of Ultramafic Rocks -- 6 Metamorphism of Dolomites and Limestones -- 7 Metamorphism of Pelitic Rocks (Metapelites) -- 8 Metamorphism of Marls, Marlstones (Marlites) -- 9 Metamorphism of Mafic Rocks -- 10 Metamorphism of Quartzofeldspatic Rocks.
    Abstract: This new edition of the classic textbook presents a large number of diagrams showing the stability relations among minerals and groups of minerals found in metamorphic rocks. The diagrams help to determine the pressure and temperature conditions under which a given set of metamorphic rocks may have formed. Other parameters that control metamorphic mineral assemblages are also discussed and pitfalls resulting from simplifications and generalizations are highlighted. The book discusses the most common metamorphic rock types, their nomenclature, structure and graphical representation of their mineral assemblages. Part I defines basic principles of metamorphism, introduces metamorphic processes, geologic thermometry and barometry and defines metamorphic grade. Part II presents in a systematic way mineralogical changes and assemblages found in the most common types of metamorphic rocks. The computation of diagrams is based on recent advances in quantitative petrology and geochemistry. An extensive bibliography, including the key contributions and classic papers in the field, make it an invaluable source book for graduate students and professional geologists.
    Type of Medium: Online Resource
    Pages: XVI, 467 p. 217 illus., 122 illus. in color. , online resource.
    Edition: 9th ed. 2023.
    ISBN: 9783031125959
    Series Statement: Springer Textbooks in Earth Sciences, Geography and Environment,
    DDC: 552
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geology. ; Tourism. ; Management. ; Geomorphology. ; Environmental geography. ; Geography. ; Geology. ; Tourism Management. ; Geomorphology. ; Integrated Geography. ; Regional Geography.
    Description / Table of Contents: Part I. Introduction and setting the scene. Chapter 1. Geotourism – A Global Overview -- Chapter 2. The Geotourism Potential of Sand and Dunes – From Theory To Practice -- Chapter 3. The Significance of Geotourism Through the Lens Of Geoethics -- Chapter 4. Geotourism in The Middle East- An Overview -- Part II. Country case studies -- Chapter 5. Geotourism in Egypt -- Chapter 6. Geotourism in Iran, A Review -- Chapter 7. Residents’ Perceptions of Geotourism in Qeshm Island UNESCO Global Geopark, Iran -- Chapter 8. Geotourism in Iraq – With Reference to Potential Geoheritage and Geoparks -- Chapter 9. Geotourism in Jordan: The Potential for Developing Geotrails in The Wadis -- Chapter 10. Geotourism In The Sultanate Of Oman – With a Focus on Samail Ophiolite Geosites -- Chapter 11. Geotourism in Qatar -- Chapter 12. Geotourism in Yemen -- Chapter 13. Geotourism in Saudi Arabia -- Chapter 14. Geotourism in Türkiye – Cave Assessment Using Geographical Information Systems -- Chapter 15. Geotourism in Palestine -- Chapter 16. Geotourism in the United Arab Emirates -- Part III. Conclusion. Chapter 17. Conclusion - The Future of Geotourism in The Middle East.
    Abstract: The geotourism industry has grown rapidly in recent years. This book introduces the geotourism industry, its attractions, activities and developments, in selected countries of the Middle East. A number of publications and studies have investigated the nature and scope of the phenomenon of geotourism (tourism which starts from geology) and geotourists worldwide. However, despite the breadth of these studies, few publications have investigated the phenomena in the Middle Eastern countries. Consequently, this book seeks to shed light on the different aspects of geotourism and geo-diversity in the Middle East and provides a number of case studies from this region. It assists in bridging the lacuna in the tourism and geology literature and helps planners, marketers, managers, scholars and researchers to enhance their knowledge about such issues. It outlines opportunities for, as well as barriers to, geotourism development in the Middle East as well as providing recommendations for the advancement of geotourism in the region.
    Type of Medium: Online Resource
    Pages: XV, 278 p. 240 illus., 232 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031241703
    Series Statement: Geoheritage, Geoparks and Geotourism, Conservation and Management Series,
    DDC: 551
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Africa History. ; Geography. ; Surveying. ; Geology. ; Human ecology Study and teaching. ; Water. ; African History. ; Geography. ; Surveying. ; Geology. ; Environmental Studies.
    Description / Table of Contents: Part I. General hydrographic description of the Haut-Congo Basin -- Chapter 1. Introduction to the general geography of the DRC -- Chapter 2. Early shipping on the Haut-Congo -- Chapter 3. From the source to Kisangani: The Upper-Congo -- Chapter 4. From Kisangani to Mbandaka: The High Middle-Congo and Ubangi -- Chapter 5. The Low Middle-Congo: From Mbandaka to Tsumbiri -- Chapter 6. The last stretch to Kinshasa: The Congo Couloir -- Chapter 7. The Upper-Kasai watershed -- Chapter 8. The Sankuru, Fimi-Lukenie and Lower-Kasai tributaries -- Chapter 9. The Kwango and Kwilu River watersheds -- Chapter 10. The Congo Cataracts -- Part II. Early European mapping of the Maritime Congo River -- Chapter 11. The first Europeans venture up the Congo Estuary -- Chapter 12. The Kouilou-Niari, an alternative access? -- Chapter 13. The voyage from Europe to Congo -- Part III. The Hydrography of the Maritime Congo River -- Chapter 14. Introduction to the Bas-Congo -- Chapter 15. Early maps of the maritime river -- Chapter 16. The acute need for bathymetric surveys -- Chapter 17. Hydrographic basics in the tropics -- Chapter 18. A new navigation channel in the making -- Chapter 19. The Mateba Deceiving Bend (Barrage du Faux Bras de Mateba) -- Chapter 20. Difficult years -- Chapter 21. Independence in 1960 -- Chapter 22. Based on detailed land surveys -- Chapter 23. Epilogue: A concept for the future?
    Abstract: In a time without GPS and echosounder, European engineers and black labourers worked for decades to get a better understanding of the nautical intricacies of the Congo River. This is the first comprehensive story, in text and custom-made maps, of the, in flow, second largest river in the world. We follow the earliest explorers mapping the river, the expeditions to find an alternative access to the ocean and the first land and hydraulic surveys to improve navigation. The constant movement of shallows and islands keeps the guardians of the river constantly on their toes. Over the years, better technologies on all fronts improved safety, data collection and fairway maintenance. In conclusion, the author describes a proposal to develop a 21st container port that would rival any port facilities on the African west coast.
    Type of Medium: Online Resource
    Pages: XV, 205 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031410659
    DDC: 551.48
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical policy. ; Quality of life. ; Biomedical Research. ; Health Policy. ; Quality of Life Research.
    Description / Table of Contents: Foreword: Challenges & Opportunities for LGBT Populations and Cancer in Global Oncology -- Introduction -- Africa -- A Double Dose Of Stigma – Being Gay And Living With Cancer In Kenya -- Sexual Orientation, Gender Identity and Cancer in South Africa -- Americas -- Making the Situation of TLGBI People around Cancer visible: Observations from the Andean Region -- Cancer Care Challenges for the LGBT Population in Brazil -- Cancer and the SGM Population in Canada and the United States of America -- South-East Asia -- The South-East Asia Region: Societal Conditions for LGBT Health and Cancer Research -- Europe -- Foreword: The Eurocentralasian Lesbian* Community Perspective on Cancer and LBQ women: Advocating for more Research and Activism Collaboration -- LGBT+ and Cancer in the WHO European Region: Current Situation in 12 Eastern European and Central Asian Countries -- Sexual and Gender Minorities and Cancer in Germany: The Striking Absence of Understanding their Cancer-related Needs -- LGBT Populations and Cancer in the UK -- Eastern Mediterranean -- LGBT Populations and Cancer in the Eastern Mediterranean Region: Insights and Challenges with a Focus on Lebanon -- Western Pacific -- LGBT Populations and Cancer in Australia and New Zealand -- Challenges in Cancer Control Confronting the LGBT Population in China: Health Risks, Unique Barriers, and Unmet Needs -- What Have We Learned about Cancer and the Global LGBT Community? -- Index.
    Abstract: Lesbian, Gay, Bisexual, and Transgender (LGBT) also known as sexual and gender minority (SGM) populations have been the focus of global attention. Most importantly, LGBT populations have been addressed in the context of human rights in multiple reports and other activities by the United Nations and other international organizations. There is great variation among countries in the recognition of LGBT individuals’ human rights. A global focus on LGBT populations’ health is still limited, with the notable exception of HIV research. This book on LGBT populations and cancer in the global context is, therefore, an important step in that it will broaden the focus on LGBT populations’ health. Globally, cancer is the second leading cause of death. Cancer morbidity and mortality are increasing disproportionately among populations in lower-income countries. A review conducted by the World Health Organization (WHO) found that of the 82% of member states (158) countries, only 35% of the national cancer control plans addresses vulnerable population, including LGBT populations. These findings reflect an increasing awareness about equity when addressing cancer prevention and control, including LGBT populations. This book addresses LGBT populations’ cancer burden across countries that range from high- to low-income countries to support efforts in diverse countries that are working towards reducing LGBT populations’ cancer burden. It documents place-specific challenges that impede progress towards reducing the LGBT cancer burden as well as critically assesses the variation in cancer control efforts that target LGBT populations and cancer to support progress at a global scale. This book includes six sections that cover the six WHO regions, with each chapter written by an author from the specific region s/he is covering. Each chapter makes use of a template that contextualizes the region, local data collection/availability, risk factors, cancer prevention, detection, diagnosis, treatment, and survivorship.
    Type of Medium: Online Resource
    Pages: X, 335 p. 3 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031065859
    DDC: 610.72
    Language: English
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    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Entrepreneurship. ; New business enterprises. ; Public health. ; Biotechnology. ; Biomedical Research. ; Entrepreneurship. ; Public Health.
    Description / Table of Contents: Part I. What Is Wrong with Health? What Should the Future of Health Be? -- INNOVATION DESIGN for the FUTURE of HEALTH -- Health Innovations from an Innovators’ Perspective -- From SICKCARE to HEALTHCARE to HEALTH -- Future Look on Health: Opportunities -- Navigating Towards a Future of “One Health” -- Part II. Exponential Medicine + Technologies + Mindset -- Exponential Technologies for an Exponential Medicine -- Exponential Medicine: Challenges of Human Spaceflight Bringing Innovations for Earth—A Case Study -- Healthy Longevity -- The Science of Health Longevity -- Space Healthtech: Innovation Base for Longevity -- Part III. Future Health Value Propositions -- Healthcare the Melting Pot of Technology, Humanity, and Confusion -- Democratize Health Delivery -- Health Innovation Process: Definitions and Short Methodology Introductions -- Prevention, Prediction, Personalization, and Participation as Key Components in Future Health -- Digital Health Business Models: Transformation Is on the Horizon -- Value Propositions for Future Health Developments: Digital, Portable, Connected, Experience-Enhancing, Supportive, Patient-Centric, and Affordable -- (Digital) Patient Journey and Empowerment: Digital Twin -- Part IV. Innovation Methodology Basics -- Stanford Biodesign as Base: Empathy and Patient Centricity as the Main Driver -- Purpose Launchpad Methodology: Introduction -- Design Thinking for Innovations in Healthcare -- VPC to BMC to Exponential Canvas: Canvas Interconnectivity for Exponential Scaling -- Innovation Methodology I3 EME: Awareness for Biomedical Engineers -- Part V. Ethics + Health Innovation -- Integrating Ethical Considerations into Innovation Design -- Part VI. Health Innovation Design -- Case Studies Used Throughout the Book: Innovation Categories Explained -- Why Is Healthcare Different with Respect to Innovation and Entrepreneurial Activities? -- Purpose Launchpad Health (PLH) Methodology Introduction -- Part VII. Purpose Launchpad Health -- Purpose Launchpad Health: Exploration and Evaluation Phases—Actual Case Studies -- Part VIII. Health Leadership, Skills and other Methodologies -- Soft Skills Needed for Problem Understanding and Innovation Generation -- Leadership in Healthcare: A Novel Approach. Healthcare Executives’ Traits, Styles, and Approaches -- Future Skills Framework in Healthcare -- Porter’s Five Forces Analysis: Quo Vadis Immunotherapy Industry -- Part IX. Health Entrepreneurship -- Global Health Markets and Their Different Needs -- Patient: Health Relation and Digital Health Entrepreneurship -- Health Start-Up: Create Impact and be Investment Ready Intra- and Entre-Preneurs -- Regulatory Issues for Health Innovations -- Innovation Think Tank Frameworks for Resolving “The Innovator’s Dilemma” in Healthcare -- A Primer on Patents and IP for Health Innovations -- Successfully Implementing Ambidexterity in the Medical Industry -- Reverse Innovation: Circumvent Digital Health Transformation Issues -- Part X. Health Innovation Education and Incubation -- Health Innovation Design: “CAMPing” for the Unmet Clinical Need -- Health Technology Innovation Generation (HTIG) Lecture and Project Classes at AGH University -- Health Innovation Design at a University: INKA INNOLAB at Otto-von-Guericke-University -- Clinical Innovation at Acibadem Biodesign Center -- Example of a Needs-Driven Innovation Training Program: The BioMedical Design Novo Nordisk Foundation Fellowship Program -- Addressing the Healthcare Needs with Innovation Think Tank Global Infrastructure and its Methodology -- The Power of a Collaborative Ecosystem: Introducing the Edison™ Accelerator -- HealthTec Networks and Clusters (Global): Innovation Clusters in Medtech in Europe -- Leadership-Compass: “Networking and Synapting Empowered by Health Captains” -- Part XI. Purpose Launchpad Health: Toolset Templates and Principles -- PLH Templates and Principles.
    Abstract: This book highlights the reasons for an urgently needed revision of the current global healthcare setup, discusses the needed mindset for a future of health, and provides a comprehensive development toolset for disruption (and for the needed incremental innovations towards disruption). Today’s biomedical and health innovation related research in universities encourages activities that lead to incremental innovations with a relatively low risk of failure. The healthcare industry on the other hand provides tools and devices for established healthcare providers to improve the diagnosis and therapy/ treatment of the patients’ health problems. The patient is not in the center of healthcare provision however, and prevention and prediction are not core goals. The current health setup needs to be challenged and disrupted. Disruptions are coming from technologies or processes that lead to a significant (〉10x) reduction in cost or price/ performance and that also come with new business models. The need for change, effects of exponential technologies, and the needed shift to prevention and to homecare for health democratization and patient empowerment will be discussed in detail in the first parts of the book. The subsequent sections address several innovation methods with a focus on a novel meta methodology named Purpose Launchpad Health. This is followed by a comprehensive discussion on health entrepreneurship activities and needs. The final section of the book addresses how to train students to become entrepreneurial health innovators, presenting successful curricula and examples of health incubation and accelerator setups. All of the innovation tools presented and used in this book are summarized in the final chapter to help the reader get started planning an entrepreneurial venture. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments. Chapters are concise and enriched with key messages, learning objectives and real innovation examples to bridge theory and practice. This book aims to serve as a teaching base for health innovation design and to prepare for health-related entrepreneurial ventures. Readers with medical, biomedical, biotechnology, and health economics backgrounds - and anyone who wants to become a future oriented health innovator or who believes in disruptive approaches - will find this book a useful resource and teaching tool for developing validated products/ services and processes for the future of health.
    Type of Medium: Online Resource
    Pages: XXXIV, 624 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031081910
    DDC: 660.6
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical microbiology. ; Parasitology. ; Biomedical Research. ; Medical Microbiology. ; Parasitology.
    Description / Table of Contents: Preface -- Chapter1. Advances in experimental research about periodontitis: lessons from the past, ideas for the future (Julien Santi-Rocca) -- Part I: Periodontal microbiota -- Chapter 2. Microbiota in Periodontitis: advances in the omic era (Shao Bing Fong, Emile Boyer, Martine Bonnaure-Mallet, Vincent Meuric) -- Chapter 3. Aggregatibacter actinomycetemcomitans: from basic to advanced research (Abdelhadi Hbibi, Amal Bouziane, Badiaa Lyoussi, Mimoun Zouhdi, Driss Benazza) -- Chapter 4. Meta-analyses on the Periodontal Archaeome (Jéssica Alves de Cena, Yuri Silvestre-Barbosa, Aline Belmok, Cristine Miron Stefani, Cynthia Maria Kyaw, Nailê Damé-Teixeira) -- Chapter 5. Parasites in periodontal health and disease: a systematic review and meta-analysis (David Felipe Martin-Garcia, Malik Sallam, Gabriela Garcia, Julien Santi-Rocca) -- Chapter 6. Fungi - a component of the oral microbiome involved in periodontal diseases (Justyna Karkowska-Kuleta, Dorota Satala, Magdalena Smolarz, Marcin Zawrotniak, Maria Rapala-Kozik) -- Chapter 7. Herpesviruses in periodontitis: An umbrella review (Aleksandar Jakovljevic, Miroslav Andric, Jelena Jacimovic, Jelena Milasin, Javier Enrique Botero) -- Part II: Periodontitis pathophysiology -- Chapter 8. Recent updates on microbial biofilms in periodontitis: an analysis of in vitro biofilm models (Maick Meneguzzo Prado, Nathalia Figueiredo, Andréa Pimenta, Tamires Szeremeske Miranda, Magda Feres, Luciene Cristina Figueiredo, Josiane de Almeida, Bruno Bueno-Silva) -- Chapter 9. Update on B cell response in periodontitis (Julien Demoersman, Jacques Olivier Pers) -- Chapter 10. Polarization profiles of T lymphocytes and macrophages responses in periodontitis (Franco Cavalla, Marcela Hernández) -- Chapter 11. Complementary experimental methods in genetics open up new avenues of research to elucidate the pathogenesis of periodontitis (Arne S. Schaefer) -- Part III: Periodontitis-associated conditions -- Chapter 12. Update on the bidirectional link between diabetes and periodontitis (Leila Salhi, Michèle Reners) -- Chapter 13. Periodontitis as a risk factor for Alzheimer’s disease: the experimental journey so far, with hope of therapy (Alice Harding, Shalini Kanagasingam, Richard Welbury, Sim K. Singhrao) -- Chapter 14. Cardiovascular diseases and periodontitis (Peter Riis Hansen, Palle Holmstrup) -- Part IV: Therapeutic management of periodontitis -- Chapter 15. Update on the role of cytokines as oral biomarkers in the diagnosis of periodontitis (Triana Blanco-Pintos, Alba Regueira-Iglesias, Carlos Balsa-Castro, Inmaculada Tomás) -- Chapter 16. Non-surgical periodontal treatment: SRP and innovative therapeutic approaches (Alexia Vinel, Antoine Al Halabi, Sébastien Roumi, Hélène Le Neindre, Pierre Millavet, Marion Simon, Constance Cuny, Jean-Sébastien Barthet, Pierre Barthet, Sara Laurencin-Dalicieux) -- Chapter 17. Update on the roles of oral hygiene and plaque control on periodontal disease (Leila Salhi, Bruno De Carvalho, Michèle Reners) -- Chapter 18. Multi-photonic adjunctive therapy for the management of periodontitis: recent advances and new treatment approach (Marco Giannelli, Daniele Bani) -- Chapter 19. Probiotics during the therapeutic management of periodontitis (Flavia Furlaneto, Karin Hitomi Ishikawa, Michel Reis Messora, Marcia P A Mayer) -- Chapter 20. Periodontal cell therapy: a systematic review and meta-analysis (Antoine Dubuc, Valérie Planat-Bénard, Mathieu Marty, Paul Monsarrat, Philippe Kémoun) -- Index.
    Abstract: Periodontitis is a disease that affects more than half the adult population in the world. Treatment is often based on ancient recommendations consisting in mechanically removing material from damaged zones. However, novel therapeutic management strategies exist, from prevention to efficient treatment, and regeneration. The need of integrative approaches to circumvent this worldwide pledge can be achieved through: A better understanding of this complex disease by promoting scientific research and a comprehensive multidisciplinary approach, including epidemiology, microbiology, immunology, physiology, therapeutics, psychology, etc. A better outreach by promoting vulgarization and recommendations for health professionals. A better information of the empowered patients, leading them to consider prevention and to take part in their therapeutic course. The book “Periodontitis: Advances in Experimental Research” includes a timely collection of chapters covering all the fields of research about periodontitis, consisting in concise reviews by the best specialists themselves and with clinical perspectives for periodontitis. Recent technological advances have allowed to explore shadowed areas of periodontology. The book “Periodontitis: Advances in Experimental Research” is a unique occasion to set a milestone for a more integrated field of periodontitis, with a broad scientific, medical, and public audience thanks to dedicated sections in each chapter: Abstract and main body (scientific audience and expert clinicians) Highlights (scientific audience and clinicians) Impact for Practice (clinicians and economical/political decision makers) Summary for Patients (patients and economical/political decision makers).
    Type of Medium: Online Resource
    Pages: XIII, 402 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030968816
    Series Statement: Advances in Experimental Medicine and Biology, 1373
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medical sciences. ; Medicine Research. ; Biology Research. ; Science Social aspects. ; Communication in science. ; Penmanship. ; Health Sciences. ; Biomedical Research. ; Science and Technology Studies. ; Science Communication. ; Writing Skills.
    Description / Table of Contents: Part I. Introduction: The Pathway to Publishing -- Part II. Most common errors -- 1. General research and writing practices -- 2. Content of quantitative papers -- 3. Mechanics of writing -- 4. Grammatical structures and stylistic strategies -- 5. Achieving clarity and conciseness -- 6. Recording scientific data -- 7. Approaching publication -- 8. Slide and poster presentations.
    Abstract: Writing manuscripts is central to the advance of scientific knowledge. For an early career aspiring scientist, writing first author manuscripts is an opportunity to develop critical skills and to credential their expertise. Writing manuscripts, however, is difficult, doubly so for scientists who use English as a second language. Many science students intentionally avoid a writing-intensive curriculum. Careful, thorough reviews of draft manuscripts are difficult to secure, and experienced scientific supervisors face more demands on their time than they have time available. Weak draft manuscripts discourage supervising scientists investing the time to coach revisions. It is easier for experienced scientists to ignore the request, or to simply rewrite the article. Early career scientists are motivated to address these barriers but specific advice is difficult to find, and much of this advice is behind a pay wall. This essential, open access text presents writing lessons organized as common errors, providing students and early-career researchers with an efficient way to learn, and mentors with a quick-reference guide to reviewing. Error descriptions include specific examples drawn from real-world experiences of other early-career writers, and suggestions for how to successfully address and avoid these in the future. Versions of this book have been used by Stanford University, UC Davis, Johns Hopkins, and numerous international institutions and organizations for over a decade. This book is licensed under the terms of the Creative Commons Attribution 4.0 International License "http://creativecommons.org/licenses/by/4.0/", which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made The images or other third party material in this book are included in the book's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the book's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
    Type of Medium: Online Resource
    Pages: XIII, 186 p. 55 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030981754
    DDC: 610
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Cytology. ; Neurosciences. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Cell Biology. ; Neuroscience. ; Biomedical Research. ; Pharmacology.
    Description / Table of Contents: A historical and evolutionary view of tight junctions -- Tricellular tight junctions -- Mechanosensitivity of tight junctions -- Intracellular traffic and non-canonical roles of ZO-2 protein -- Impact of claudin-2 and occludin expression in inflammation disorders -- Tight junctions in the inflamed gut -- Intestinal barrier disruption by enteropathogenic Escherichia coli -- Tight junction barrier function regulation by microbiota -- Claudin-7 participation in cell-substrate adhesion, cell migration, salt balance in the renal collecting duct and gut cell renewal and differentiation -- Regulation of the alveolar epithelial barrier by claudin-5 -- Regulation of the blood-retinal barrier by occludin phosphorylation, norrin and sonic hedgehog signaling -- Transmigration of metastatic cells through the blood-brain barrier -- Endocytosis of tight junction proteins -- Regulated degradation of claudins. .
    Abstract: This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.
    Type of Medium: Online Resource
    Pages: XII, 334 p. 47 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030972042
    DDC: 571.6
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Life sciences. ; Chemistry, Organic. ; Enzymology. ; Biochemistry. ; Biomedical Research. ; Life Sciences. ; Organic Chemistry. ; Enzymology. ; Biochemistry.
    Description / Table of Contents: 1. Alkanes, composition, constitution, and configuration -- 2. Functional groups -- 3. Electronic structure of organic molecules -- 4. Alkenes and alkynes -- 5. Substitutions on saturated carbon atom -- 6. Nucleophilic additions -- 7. Stereochemistry, symmetry, and molecular chirality -- 8. Derivatives of carboxylic acids -- 9. Electrophilic substitutions -- 10. Pericyclic reactions -- 11. Organic natural products -- 12. Organic supramolecular and supermolecular structures.
    Abstract: This textbook is designed for students of biology, molecular biology, ecology,medicine, agriculture, forestry and other professions where the knowledge of organic chemistry plays an important role. The work may also be of interest to non-professionals, as well as to teachers in high schools. The book consists of 13 chapters that cover the essentials of organic chemistry, including - basic principles of structure and constitution of organic compounds, - the elements of the nomenclature, - the concepts of the nature of chemical bond, - introductions in NMR and IR spectroscopy, - the concepts and main classes of the organic reaction mechanisms, - reactions and properties of common classes or organic compounds, - and the introduction to the chemistry of the natural organic products followed by basic principles of the reactions in living cells. This second edition includes revisions and suggestions made by the readers of the first edition and the author's colleagues. In addition, it includes substantial changes compared to the first edition. The chapter on Cycloaddition has been completed by including the other pericyclic reactions (sigmatropic rearrangements, electrocyclic reactions). The chapter on Organic Natural Products has been extended to include new section covering the principles of organic synthesis. New chapter "Organic Supramolecular and Supermolecular Structures" is added. This chapter covers the basic knowledge about the molecular recognition, supramolecular structures, and the mechanisms of the enzyme catalyzed reactions.
    Type of Medium: Online Resource
    Pages: XV, 205 p. 339 illus., 114 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030924386
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Cytology. ; Biophysics. ; Cell interaction. ; Biological transport. ; Cell membranes. ; Medicine Research. ; Biology Research. ; Cell Biology. ; Mechanobiological Cell Signaling. ; Membrane Trafficking. ; Biomedical Research.
    Description / Table of Contents: Part 1: Functions of Macropinocytosis -- Chapter 1: Functional Diversity of Macropinocytosis -- Chapter 2: Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways -- Chapter 3: The amoebal model for micropinocytosis -- Chapter 4: Extracellular ATP and macropinocytosis -- Chapter 5: Macropinocytosis and Cell Migration: Don't drink an drive -- Chapter 6: Macropinocytosis in phagocyte function and immunity -- Part 2: Signaling Mechanisms Driving Macropinocytosis -- Chapter 7: Roles of 3' Phosphoinositides in Macropinocytosis -- Chapter 8: Signaling pathways that regulate macropinocytosis in mammalian cells -- Chapter 9: Wnt, GSK3 and Macropinocytosis -- Chapter 10: Kras addiction promotes cancer cell adapation in harsh microenvironment through micropinocytosis -- Chapter 11: Kras-independent macropinocytosis in pancreatic cancer.
    Abstract: This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process. Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students.
    Type of Medium: Online Resource
    Pages: XI, 224 p. 28 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030940041
    Series Statement: Subcellular Biochemistry, 98
    DDC: 571.6
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Pharmacy. ; Public health. ; Medicine. ; Medical care. ; Medical economics. ; Medicine Research. ; Biology Research. ; Pharmacy. ; Public Health. ; Clinical Medicine. ; Health Care. ; Health Economics. ; Biomedical Research.
    Description / Table of Contents: Prologue: Many questions, no answers -- Part 1: Crisis, what crisis...? -- 1. Too Late -- 2. Don’t Rely on Your Prescription -- 3. Chronic Disease? -- 4. No Prevention -- 5. Male Plus Low Income = Double Whammy -- 6. False Incentives -- 7. The End of Big Pharma -- 8. Research Not for Patients -- 9. Organ-Based Medicine -- 10. Interjection 1: How Healthy Do You Want to Be?.-Part 2: The Medicine of the Future -- 11. Re-Discover the Whole Patient -- 12. Research for patients -- 13. Know Your Genes -- 14. Outnumbered -- 15. Your Exposome -- 16. Big Data Medicine -- 17. Healed -- 18. Well-Tech -- 19. Interjection 2: Superhumans -- Part 3: The Future has Begun... -- 20. Self-diagnosis -- 21. Self-therapy -- 22. Your Digital Twin. Epilogue: Nobody Is Sick Anymore -- Appendix 1: Special Page 1 -- Appendix 2: Special Page 2. .
    Abstract: Medicine itself is sick. We hardly understand any disease and therefore need to chronically treat symptoms but not the causes. Consequently, drugs and other therapies help only very few patients; yet we are pumping more and more money into our healthcare system without any added value and neglect prevention. Thus, the internationally renowned physician scientist, Harald H.H.W. Schmidt, MD, PhD, PharmD, professor at Maastricht University, predicts the end of medicine as we know it. On a positive note, digitization will radically change healthcare and lead to one of the greatest socioeconomic revolutions of mankind. He is one of the pioneers of "systems medicine", a complete redefinition of what we call a "disease", how we organize medicine and how we use Big Data to heal rather than treat, and to prevent rather than cure. In this book the author first proves the deep crisis of medicine, and then also describes how medicine will become more precise, more preventive, safer and, surprisingly, more affordable. “Dr. Harald Schmidt convincingly explains the limitations in the current practice of medicine and the need for big data and a systems approach.” Ferid Murad MD, PhD, Nobel Laureate in Medicine 1998 "Visionary, provocative, and full of insights. Professor Schmidt gives a unique and authoritative perspective to the past, present and future of medical science and clinical practice. And all presented in such an inimitable style." Prof. Robert F. W. Moulds, MBBS PhD FRACP, Former Dean Royal Melbourne Hospital Clinical School of the University of Melbourne, Australia The translation was performed with the help of artificial intelligence (machine translation by the service DeepL.com). Subsequent human revision including updating of each chapter was carried out mainly with a view to internationalization of the content, so that the book reads differently from a simple translation in terms of style and timeliness.
    Type of Medium: Online Resource
    Pages: XIV, 291 p. 34 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030952938
    DDC: 615.1
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Description / Table of Contents: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges -- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer -- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk -- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics -- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research -- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions -- Ion Transport and Radioresistance -- Ion Transporting Proteins and Cancer: Progress and Perspectives.
    Abstract: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges Alina L. Capatina, Dimitris Lagos, and William J. Brackenbury Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer Ana Ramírez, Janice García-Quiroz, Luis Aguilar-Eslava, Yesennia Sánchez-Pérez, and Javier Camacho Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk Jerry J. Fan and Xi Huang Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics Umberto Banderali, Luigi Leanza, Najmeh Eskandari, and Saverio Gentile Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research Marie Potier-Cartereau, William Raoul, Gunther Weber, Karine Mahéo, Raphael Rapetti-Mauss, Maxime Gueguinou, Paul Buscaglia, Caroline Goupille, Nelig Le Goux, Souleymane Abdoul-Azize, Thierry Lecomte, Gaëlle Fromont, Aurélie Chantome, Olivier Mignen, Olivier Soriani, and Christophe Vandier Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions Jason T. Anderson, Kevin M. Huang, Maryam B. Lustberg, Alex Sparreboom, and Shuiying Hu Ion Transport and Radioresistance Bastian Roth and Stephan M. Huber Ion Transporting Proteins and Cancer: Progress and Perspectives Mustafa B. A. Djamgoz.
    Type of Medium: Online Resource
    Pages: X, 277 p. 30 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031039942
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 183
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Molecular biology. ; Metabolism. ; Genetics. ; Cytology. ; Biomedical Research. ; Molecular Biology. ; Metabolism. ; Genetics and Genomics. ; Cell Biology.
    Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.
    Abstract: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
    Type of Medium: Online Resource
    Pages: XII, 346 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031118364
    Series Statement: Advances in Experimental Medicine and Biology, 1390
    DDC: 610.72
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Anatomy. ; Medical education. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Anatomy. ; Medical Education. ; Virtual and Augmented Reality.
    Description / Table of Contents: Part I. Healthcare -- Chapter 1. Is It Time to FONA Friend? A Novel Mixed Reality Front of Neck Access Simulator -- Chapter 2. “Learning About Skin Breakdown” – Design, Development and Evaluation of an Augmented Reality Application to Inform about Pressure Ulcers (sores) and Moisture Lesions -- Chapter 3. The Use of 3D-Printing and Injection Moulding in the Development of a Low-Cost, Perfused Renal Malignancy Model for Training of Robot-Assisted Laparoscopic Partial Nephrectomy -- Chapter 4. The Co-IMMUNicate App: An Engaging and Entertaining Education Resource on Immunity to Respiratory Viruses -- Part II. Education -- Chapter 5. Application of AR and 3D Technology for Learning Neuroanatomy -- Chapter 6. Communicative Powers of Interactive Digital Mediums in the Field of Polyomics -- Chapter 7. SkilletonVR: Canine Skeleton VR -- Chapter 8. Using Holograms to Engage Young People with Anatomy -- Chapter 9. The Digital Dolphin: Are 3D Mobile Based and Interactive Models a Useful Aid to Volunteers on Stranding Schemes Learning the Basic Anatomy and Pathology of Cetaceans? -- Chapter 10. The Impact of the COVID Crisis on Anatomical Education: A Systematic Review.
    Abstract: This edited book explores the use of technology to enable us to visualize the life sciences in a more meaningful and engaging way. It will enable those interested in visualization techniques to gain a better understanding of the applications that can be used in visualization, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualization techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilization of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. We have something for a diverse and inclusive audience ranging from healthcare, patient education, animal health and disease and pedagogies around the use of technologies in these related fields. The first four chapters cover healthcare and detail how technology can be used to illustrate emergency surgical access to the airway, pressure sores, robotic surgery in partial nephrectomy, and respiratory viruses. The last six chapters in the education section cover augmented reality and learning neuroanatomy, historical artefacts, virtual reality in canine anatomy, holograms to educate children in cardiothoracic anatomy, 3D models of cetaceans, and the impact of the pandemic on digital anatomical educational resources.
    Type of Medium: Online Resource
    Pages: IX, 323 p. 270 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031067358
    Series Statement: Biomedical Visualization, 1
    DDC: 610.72
    Language: English
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  • 88
    Keywords: Medicine Research. ; Biology Research. ; Nanotechnology. ; Cancer Treatment. ; Biomedical Research. ; Nanotechnology. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1. The tumor microenvironment -- Chapter 2. Methods of formulation of polymeric nanoparticles -- Chapter 3. Natural polymers based nanoparticles targeted to solid tumors -- Chapter 4. Optimization of physicochemical properties of polymeric nanoparticles for targeting solid tumors -- Chapter 5. Passive and active targeting approaches for solid tumors -- Chapter 6. Polymeric nanoparticles entrapping natural drugs for cancer therapy -- Chapter 7. Polymeric nanoparticles entrapping drug combinations targeted to solid tumors -- Chapter 8. Ligands specific to over-expressed receptors in solid tumors -- Chapter 9. Ligand targeted polymeric nanoparticles for cancer chemotherapy -- Chapter 10. Polymeric nanoparticles as theranostics for targeting solid tumors -- Chapter 11. Oral delivery of polymeric nanoparticles for solid tumors -- Chapter 12. Polymeric nanoparticles to target glioblastoma tumors -- Chapter 13. Polymeric nanoparticles to target lung cancer -- Chapter 14. Polymer based nanoplatforms for targeting breast cancer -- Chapter 15. PH-Sensitive polymeric nanoparticles for cancer treatment -- Chapter 16. Polymeric nanoplatforms for targeted treatment of prostate cancer -- Chapter 17. Cellular internalization and toxicity of polymeric nanoparticles -- Chapter 18. Prospects and challenges in the treatment of solid tumors.
    Abstract: This book focuses on the emerging research in the field of treatment of solid tumors or cancer with new drug delivery systems using nanotechnology. Nanotechnology has given us a good scope for development of new innovative drug delivery strategies to increase the therapeutic efficacy of anticancer drugs with reduced off-target side effects. Cancer is one of the main causes of death worldwide due to the limitations of classical therapies such as low solubility of active drugs, toxic side effects on healthy cells and resistance of tumor cells. These issues are partly solved by the recent development of polymeric nanoparticles, which improve drug absorption and the therapeutic index, while reducing side effects. Drug carriers must be biocompatible, biodegradable and non-immunogenic. Coupled to a ligand that has affinity for that particular cell, polymeric nanoparticles are used to target specifically malignant cells or tissues and, in turn, improve drug stability. This book presents the latest advances in the application of polymeric particles for cancer treatment, with focus on the tumor microenvironment, synthesis, active and passive targeting, patents, targeting over-expressed receptors, tumor-targeting ligands, theranostics, glioblastoma tumors, lung cancer, breast cancer, prostate cancer and pH-responsive nanoparticles.
    Type of Medium: Online Resource
    Pages: X, 512 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031148484
    Series Statement: Environmental Chemistry for a Sustainable World, 71
    DDC: 610.72
    Language: English
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  • 89
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Bioinformatics. ; Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Bioinformatics.
    Description / Table of Contents: Involvement of Endothelial Nitric Oxide Synthase in Cerebral Microcirculation and Oxygenation in Traumatic Brain Injury -- Imaging cerebral energy metabolism in healthy infants -- Changes in cerebral oxygenation and systemic physiology during a verbal fluency task: Differences between men and women -- Brain Tissue Conductivity in Focal Cerebral Ischemia -- Physical stress Attenuates Cognitive inhibition: An fNIRS Examination -- Changes in Prefrontal Cortical Oxygenation During Tilt Table Orthostatic Hypotension in Subarachnoid Haemorrhage Patients -- Effects of different optical properties of head tissues on near-infrared spectroscopy Using Monte Carlo Simulations -- Frontal cerebral oxygenation in humans at rest: A mirror symmetry in the correlation with cardiorespiratory activity -- Photomodulation of lymphatic delivery of bevacizumab to the brain: the role of singlet oxygen -- NIRS-based study of local cerebral oxygenation during transcranial direct current stimulation in patients with mild traumatic brain injury -- Postnatal Exposure to Brief Hypoxia Alters Brain VEGF Expression and Capillary Density in Adult Mice -- Impaired Cognitive Performance in Mice Exposed to Prolonged Hyperoxia -- Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain -- Motor Imagery and Frontal Head Oxygenation: An fNIRS Study -- Non-invasive detection of persistent cortical hypoxia in Multiple Sclerosis using frequency domain near-infrared spectroscopy (fdNIRS) -- Evaluation of intraoperative end-tidal Carbon dioxide change relates to length hospitalization in peridiaphragmatic surgery: a pilot study -- Pulmonary Embolism in COVID-19 patients is not related to a worsening in tissue oxygenation -- Cardiovascular risk score and gas exchange in COVID-19 patients: no correlation -- Heme Oxygenase 1/ High Mobility Group Box 1 pathway may have a possible role in Covid-19 ARDS (Acute respiratory distress syndrome): a pilot histological study -- Silent Hypoxemia in COVID-19 pneumonia -- Low Flow and Microvascular Shunts: A Final Common Pathway to Cerebrovascular Disease: A Working Hypothesis -- A case of intracranial vertebral artery stenosis treated with percutaneous transluminal angioplasty and stenting guided by brain oximetry -- Assessment of Optimal Arterial Pressure with Near-Infrared Spectroscopy in Traumatic Brain Injury Patients -- Effects of exercise-diet therapy on cognitive function in healthy elderly people evaluated by deep learning based on basic blood test data -- NIRS studies show reduced interhemispheric functional connectivity in individuals with Multiple Sclerosis that exhibit cortical hypoxia -- Eye Tracking Parameters Correlate With the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study -- Critical closing pressure of cerebral circulation at concomitant moderate-to-severe traumatic brain injury -- Hybrid convolutional neural network (hCNN) for image reconstruction in near-infrared optical tomography -- Cross-frequency coupling between brain and body biosignals: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Machine learning distinguishes familiar from unfamiliar pairs of subjects performing an eye contact task: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates With Asphyxia -- Basic examination of hemoglobin phase of oxygenation and deoxygenation in resting state and task periods in adults using fNIRS -- Development and validation of robust and cost-effective liquid heterogeneous phantom for time domain near-infrared optical tomography -- Effect of Exercise Therapy on Stress Response Evaluated by IoMT Monitoring System -- Improved optical tissue model for tissue oximetry imaging applications -- In vitro validation of a new tissue oximeter using visible light -- Photon and Proton Dose Painting based on Oxygen Distribution – Feasibility Study and Tumour Control Probability Assessment -- Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells -- Feasibility of non-invasive measurement of tumor NAD(H) by in vivo phosphorus-31 magnetic resonance spectroscopy -- Acidosis-induced regulation of Egr1 and Ccn1 in vitro and in experimental tumors in vivo -- Perfusion-Limited Hypoxia Determines the Outcome of Radiation Therapy of Hypoxic Tumours -- Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers upon Mild Hyperthermia Delivered by wIRA-Irradiation -- Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy -- Optical Redox Imaging Is Responsive to TGFβ Receptor Signaling in Triple-Negative Breast Cancer Cells -- Evaluation of betulinic acid derivatives as PET tracers for hypoxia-induced carbonic anhydrase IX (CA IX) expression -- Role of the mTOR signaling pathway during extracellular acidosis in tumor cells -- Feasibility Study of Remote Contactless Perfusion Imaging with Consumer-Grade Mobile Camera -- Stability of a Novel PEGylation site on a Putative Hemoglobin Based Oxygen Carrier -- Oxygen storage in stacked phospholipid membranes under an oxygen gradient as a model for myelin sheaths -- Confocal laser and electron microscopic investigation of gap junctions in anaplastic astrocytomas -- A radiation biological analysis of the oxygen effect as a possible mechanism in FLASH -- Assessment of nicotinamide adenine dinucleotide in human tissues by in vivo phosphorus-31 magnetic resonance spectroscopic imaging at 1.5 Tesla -- Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus -- Hemorheologic Enhancement of Cerebral Perfusion increases oxygen supply and reduces Ab plaques deposition in a mouse model of Alzheimer’s Disease -- Calorimetric Characterization of the Binding Reaction Between Human Ferric Hemoglobins and Haptoglobin to Develop a Drug for Removal of Cell-Free Haemoglobin -- Feasibility To Measure Tissue Oxygen Saturation Using Textile-integrated Polymer Optical Fibers -- Effect of Atorvastatin on Microcirculation Evaluated by Vascular Occlusion Test with Peripheral Near lnfrared Spectroscop -- Flow characteristics of the conjugate of anti-CD3 monoclonal antibodies and magnetic nanoparticle in the PBS and the blood vessel -- Cerebrovascular Reserve (CVR) and Stages of Hemodynamic Compromise -- On the mechanism of sustained mitochondrial membrane potential without functioning complex IV -- Further evidence that gradients of extracellular pH direct migration of MDA-MB-231 cells in vitro -- Blood Flow and Respiratory Gas Exchange in the Human Placenta at Term: A Data Update -- Oxyhaemoglobin Level Measured Using Near-Infrared Spectrometer is Associated with Brain Mitochondrial Dysfunction After Cardiac Arrest in Rats -- Changes in Oxygenation Levels During Moderate Altitude Simulation (Hypoxia-Induced): A Pilot Study Investigating the Impact of Skin Pigmentation in Pulse Oximetry -- The Intramuscular Circulation is Affected by Neck and Shoulder Pain -- Intramuscular circulation of the lumbar multifidus in different trunk positions on standing -- Numerical Optimization of a NIRS Device for Monitoring Tissue Oxygen Saturation -- Upper trapezius muscle tonicity, assessed by palpation, relates to change in tissue oxygenation and structure as measured by Time-Domain Near Infrared Spectroscopy -- Perceived exertion correlates with multiple physiological parameters during cardiopulmonary exercise testing -- Systemic and Quadriceps Muscle O2 Dynamics in Subjects without Attenuation Point of Deoxygenated Hemoglobin Concentration during Ramp Cycling Exercise -- Jaw-Clenching Intensity Effects on Masseter Oxygen Dynamics and Fatigue: A NIRS Oximetry Study. .
    Abstract: This book contains most of the scientific contributions during the 48th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), which was held electronically in July 2021. It includes multidisciplinary contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians and covers covers all aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence.
    Type of Medium: Online Resource
    Pages: XXVI, 446 p. 163 illus., 100 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031141904
    Series Statement: Advances in Experimental Medicine and Biology, 1395
    DDC: 571.6
    Language: English
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  • 90
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Stem cells. ; Biotechnology. ; Biomedical Research. ; Stem Cell Biology. ; Biotechnology.
    Description / Table of Contents: Chapter 1. The historical studies underpinning the concept of hair follicle neogenesis (Higgins C, Jahoda C) -- Chapter 2. Hair regeneration and rejuvenation: pipeline of medical and technical strategies (Limbu S, Kemp P) -- Chapter 3. Cells and structures involved in hair follicle regeneration: an introduction (Tsai J, Garza LA) -- Chapter 4. The dermal papilla and hair follicle regeneration: Engineering strategies to improve dermal papilla inductivity (Pantelireis N, Clavel C) -- Chapter 5. Dermal sheath and hair follicle regeneration (Yoshida Y, Tsuboi K, Kishimoto J) -- Chapter 6. Epithelial-mesenchymal interactions between hair follicles and dermal adipose tissue (Ramos R, Plikus MV) -- Chapter 7. Lymphatic vasculature and hair follicle regeneration (Cazorla A, Perez-Moreno M) -- Chapter 8. In vitro and ex vivo hair follicle models to explore therapeutic options for hair regeneration (Bertolini M, Piccini I, McElwee KJ) -- Chapter 9. Extracellular vesicles including exosomes for hair follicle regeneration (Aberdam E, le Riche A, Bordes S, Closs B, Park BS, Aberdam D) -- Chapter 10. Stem cell-based therapies for hair loss: what is the evidence from a clinical perspective? (Park BS, Choi HI) -- Chapter 11. Induced pluripotent stem cell approach for hair follicle regeneration (Pinto A, Terskikh AV) -- Chapter 12. Biofabrication technologies in hair neoformation (Abreu CM, Gasperini L, Marques AP) -- Chapter 13. Wound healing induced hair follicle regeneration (Jiang Y, Myung P) -- Chapter 14. Hair follicles in wound healing and skin remodeling (Plotczyk M, Jimenez F) .
    Abstract: This book aims to comprehensively review the current cell-based strategies under investigation to achieve the regeneration of human hair follicles. The unique capacity of the human hair follicle to self-renew explains why this complex “mini-organ” has always attracted so much interest as a model for researchers to study stem cell biology and regenerative medicine. The hair follicle is considered a main reservoir of cutaneous stem cells, containing several pools of epithelial, melanocyte, and mesenchymal stem cells involved in hair follicle self-regeneration and pigmentation. In addition, while some of the different follicular cell types contribute to hair shaft growth, others participate in very important interfollicular functions such as dermal remodeling, re-epithelialization after wounding, and cutaneous stem cell homeostasis. The idea of human hair follicle regeneration either “de novo” or by activating dormant miniaturized follicles is not new, yet still continues to arouse enormous interest in the pursuit of a definitive cure for baldness. In contrast to hair follicle regeneration in mice, the attempts made with human follicles have been disappointing in terms of efficiency. However, recent advances in stem cell biology—as well as the appearance of new technologies like 3D printing—have revived expectations in this field of research. This book is divided into four sections. The first part includes an overview of the strategies used in hair follicle regeneration and a historical summary of the most important achievements to date. Parts two and three comprise the main body of the book, with detailed descriptions of the cells and tissue structures involved in hair follicle regeneration, followed by an elaboration of the different therapeutic strategies, engineering techniques, and a clinician’s perspective of stem cell-based therapies in hair loss treatments. Finally, the fourth part reviews the important contribution of the hair follicle in healing cutaneous wounds through the regeneration and remodeling of the dermis and epidermis after injury, as well as wound induced hair follicle neogenesis that occurs when the skin is injured.
    Type of Medium: Online Resource
    Pages: XII, 307 p. 73 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030983314
    Series Statement: Stem Cell Biology and Regenerative Medicine, 72
    DDC: 610.72
    Language: English
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  • 91
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Internal medicine. ; Bioinformatics. ; Biomedical Research. ; Internal Medicine. ; Bioinformatics.
    Description / Table of Contents: Part One: Basic Concepts in Precision Oncology -- Chapter 1. Design and Implementation of a precision oncology workflow -- Chapter 2. An overview of cancer genome sequencing -- Chapter 3. Software infrastructures for precision medicine workflows -- Part Two: Current Computational Methods and Tools in Precision Oncology -- Chapter 4. Somatic and germline variant calling from next-generation sequencing data -- Chapter 5. Identification of copy number alterations from next-generation sequencing data -- Chapter 6. Genome-wide discovery of large-scale structural variants from next-generation sequencing data -- Chapter 7. Assessment of microsatellite instability from next-generation sequencing data -- Chapter 8. Computational approaches for the investigation of intra-tumor heterogeneity and clonal evolution from bulk sequencing data -- Chapter 9. Analysis of the transcriptome for precision oncology applications -- Chapter 10. Computational methods for drug repurposing -- Chapter 11. Pathway for analysis for precision oncology applications -- Chapter 12. Identification of fusion transcripts from RNA-seq -- Chapter 13. Computational resources for the interpretation of variations in cancer -- Chapter 14. Analysis of electronic health records for precision oncology -- Chapter 15. Network approaches for precision oncology -- Chapter 16. Experimental validation of genomic alterations -- Part Three: Advanced Concepts - The Future of Precision Oncology -- Chapter 17. Molecular profiling of liquid biopsies for precision oncology -- Chapter 18. Artificial intelligence for precision oncology -- Chapter 19. Single-cell technologies in precision oncology -- Chapter 20. Computational approaches for precision immuno-oncology -- Chapter 21. Multi-pmics profiling of the tumor microenvironment -- Chapter 22. Epigenetic and precision oncology -- Chapter 23. Next generation knowledge bases to support precision oncology. .
    Abstract: Precision medicine holds great promise for the treatment of cancer and represents a unique opportunity for accelerated development and application of novel and repurposed therapeutic approaches. Current studies and clinical trials demonstrate the benefits of genomic profiling for patients whose cancer is driven by specific, targetable alterations. However, precision oncologists continue to be challenged by the widespread heterogeneity of cancer genomes and drug responses in designing personalized treatments. Chapters provide a comprehensive overview of the computational approaches, methods, and tools that enable precision oncology, as well as related biological concepts. Covered topics include genome sequencing, the architecture of a precision oncology workflow, and introduces cutting-edge research topics in the field of precision oncology. This book is intended for computational biologists, bioinformaticians, biostatisticians and computational pathologists working in precision oncology and related fields, including cancer genomics, systems biology, and immuno-oncology.
    Type of Medium: Online Resource
    Pages: XIV, 336 p. 36 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030918361
    Series Statement: Advances in Experimental Medicine and Biology, 1361
    DDC: 610.72
    Language: English
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  • 92
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Immunology. ; Dermatology. ; Biomedical Research. ; Medical Genetics. ; Immunology. ; Biomedical Research. ; Dermatology.
    Description / Table of Contents: Genetics control of immune responses -- Non-melanoma skin cancer -- Melanoma -- Psoriasis -- Atopic dermatitis -- Contact dermatitis -- Lichen planus -- Pemphigus and pemphigoids -- Morphea and Lichen Sclerosus -- Granuloma annulare and Necrobiosis lipoidica -- Alopecia areata -- Vitiligo -- Acne Vulgaris and Rosacea -- Urticaria and Angioedema -- Cutaneous drug reaction -- Photodermatologic disorders -- Infantile Haemangioma and other vascular malformations.
    Abstract: This book intends to investigate the broad spectrum of genetic changes in immunological processes involved in cutaneous diseases. One of the main goals of immunogenetic studies is finding susceptibility genes for complex diseases. This can provide an insight into the pathogenesis of the condition in a way that is not easily achievable through other kinds of studies. Thus they are a rational initial step for generating hypotheses about disease pathogenesis. This may especially benefit dermatology, a field notorious for having too many diseases with unknown etiologies. Immunogenetic investigations have made targeted treatment strategies possible for diseases such as psoriasis and pemphigus. Even though these strategies have revolutionized the management of chronic dermatological conditions such as psoriasis, still there are a lot of unanswered questions. For instance, psoriasis patients respond very differently to each of the commercially available biological agents. This diversity could be partially explained by the differences in the sets of genes responsible for disease induction in each individual. Thus whole genome sequencing strategies, if feasible at individual levels, might help in tailoring these targeted treatments based on specific genetic backgrounds. Our intention in preparing this book was to explore the broad spectrum of the genetic aspects of immunological processes involved in cutaneous diseases. We have tried to cover most areas of dermatology where enough studies were available to gather a chapter. Still, there is a substantial lack of knowledge on the immunogenetics of many dermatological conditions. We hope that this book would encourage the investigators to fill these gaps of knowledge.
    Type of Medium: Online Resource
    Pages: XXI, 450 p. 64 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030926168
    Series Statement: Advances in Experimental Medicine and Biology, 1367
    DDC: 610.72
    Language: English
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  • 93
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Veterinary medicine. ; Agricultural genome mapping. ; Biomedical Research. ; Veterinary Science. ; Agricultural Genetics.
    Description / Table of Contents: Chapter 1: Outline Of Anatomy/Physiology Of Skeletal Tissues -- Chapter 2: Tumors Of The Musculoskeletal System -- Chapter 3: Tumor-Like Lesions Of The Musculoskeletal System -- Chapter 4: General Considerations About Bone Tumors -- Chapter 5: Appendix: Manual For Histological Preparation And Examination Of Tissues Containing Bone And Cartilage.
    Abstract: This book comparatively examines the etiopathogenetic, clinical-pathological, diagnostic and therapeutic strategies of the main bone tumors of domestic animals. The book also includes a description of the most significant aspects of macroscopic, microscopic, immunohistochemical, instrumental, diagnostic imaging and molecular biology aspects of spontaneous bone tumors in Veterinary Medicine, with also interspecies comparative aspects, including the human one. Last but not least, the book provides an overview of the new diagnostic and therapeutic frontiers related to the approach to animal bone tumors. The book serves as essential reading for professionals, researchers and students who work or want to tackle three paths in the field of comparative veterinary bone oncology.
    Type of Medium: Online Resource
    Pages: XV, 193 p. 90 illus., 84 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030902100
    DDC: 610.72
    Language: English
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  • 94
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Tumors Classification. ; Surgery. ; Cytokines. ; Virology. ; Biomedical Research. ; Cancer Staging. ; Surgery. ; Cytokines and Growth Factors. ; Virology.
    Description / Table of Contents: Compliance with the Surgery Safety Checklist: An Update on the Status -- Surgical Safety Checklist: Polychromatic or Achromatic Design -- Surgical Strategy and Clinical Outcome in Patients with Bronchial Carcinoids -- Frozen Section or Intraoperative Cytology: Are We Ready for a Paradigm Shift in Thoracic Surgery? -- Clinical Outcome in Patients with Nosocomial COVID-19 Infection After Thoracic Surgery -- Cytological Diagnostic Procedures in Malignant Mesothelioma -- Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions -- Cytokines in Renal Cell Carcinoma: A Step Towards Earlier Detection and Targeted Therapy -- Primary Hyperparathyroidism Secondary to Ectopic Parathyroid Adenoma: A Case Report -- Perception of Well-Being and Quality of Life in Obese Patients After Bariatric Surgery -- Do Multiple Brain Lesions Always Connote Worse Outcomes? Appraisal Evidence from a Tertiary Care Center in Koshi/Purbanchal Province of Nepal -- Radioimaging and Demographic Profiles of Patients with Spontaneous Intracerebral Hemorrhage: A Need for the Pragmatic Referral System -- Anticytokine Treatment of Rheumatoid Arthritis: An Observational Report.
    Abstract: The book is an update on contentious or unsettled issues concerning invasive diagnostic and therapeutic challenges in cancer and related disorders, focusing on the surgical approach. Topics include recommendations for the best practice in using the surgery safety checklist, surgical strategies in a variety of thoracic cancers, renal cell carcinoma, tumors of parathyroid glands, mesothelioma, and bariatric surgeries. The focus is on the diagnostic and therapeutic challenges of aggressive cancerous entities, choosing the most beneficial modes for optimal outcomes and patient survival. Chapters also address radioimaging and therapy outcomes in different intracranial lesions leading to severe neurological disabilities. The areas of medical practice addressed are still veiled in uncertainty, yet-unresolved pathogenetic background, and have a substantial component of empirical rather than evidence-based clinical approach. Pursuing and sharing new ideas and innovations is essential for improving the management and outcome. The book endeavors to disseminate and deliberate on the latest medical knowledge, studies, and advancements in surgical and diagnostic dealing with cancer. The book is addressed to physicians and surgeons, and all allied health care professionals engaged in patient care and therapy.
    Type of Medium: Online Resource
    Pages: VI, 119 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030988579
    Series Statement: Clinical and Experimental Biomedicine, 1374
    DDC: 610.72
    Language: English
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  • 95
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Physiology.
    Description / Table of Contents: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression -- Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression -- Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer -- Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues -- Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?.
    Abstract: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression Line O. Elingaard-Larsen, Michala G. Rolver, Ester E. Sørensen, and Stine F. Pedersen Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression Ebbe Boedtkjer Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer Larry Fliegel Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues Giorgia Scarpellino, Luca Munaron, Anna Rita Cantelmo, and Alessandra Fiorio Pla Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism? Christian Stock.
    Type of Medium: Online Resource
    Pages: XV, 175 p. 40 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030998004
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 182
    DDC: 610.72
    Language: English
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  • 96
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical sciences. ; Vocational guidance. ; Career education. ; Biomedical Research. ; Health Sciences. ; Career Counseling. ; Career Skills.
    Description / Table of Contents: Part 1: Getting started -- Chapter 1: The why and the what of scientific research and publishing -- Chapter 2: Understanding research ethics -- Chapter 3: How to structure a scientific article, conference poster and presentation -- Part 2: The Hidden Bumps -- Chapter 4: Who gets authorship status? -- Chapter 5: The art of journal selection -- Chapter 6: Understanding the editor’s perspectives -- Part 3: The Destination -- Chapter 7: Converting a scientific article for the media -- Chapter 8: What are research metrics and why should I care? -- Chapter 9: Beyond your scientific publication -- Chapter 10: The Editor’s Perspective – Full-Length Interviews.
    Abstract: In the age of "publish or perish," this book provides everything one needs to know about conducting research and successfully publishing it in a scientific journal. The reader learns about the complete process of scientific publishing: from selecting the most appropriate research design, to obtaining permissions and funding, to resourcefully presenting the research results in a poster and oral presentation. Additionally, the practical tips provided here help the reader formulate a compelling scientific article and choose the most suitable journal (subscription vs. the various open access modalities) for their publication. This book also addresses "invisible aspects" of scholarly publishing that are nonetheless important and that everyone should know and understand: avoiding predatory journals, understanding the editor's perspective, and becoming familiar with the various research metrics (from author to journal) that can all determine success or failure of a publication. Written in an informal style in which the author shares personal perspectives and experiences, the book is easily accessible to the reader. The book offers early career scientists in biomedicine and medicine a unique perspective on publishing research articles and how this process can enhance the authors' "scientific value" within the scientific ecosystem as well as their personal CVs.
    Type of Medium: Online Resource
    Pages: XIV, 119 p. 25 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030992958
    DDC: 610.72
    Language: English
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  • 97
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Pain medicine. ; Artificial intelligence. ; Biomedical Research. ; Pain Medicine. ; Artificial Intelligence.
    Description / Table of Contents: Artificial Intelligence and Precision Medicine: A Perspective -- Pedobarography in Physiotherapy: A Narrative Review on Current Knowledge -- Quantum Medicine: A Role of Extremely Low-Frequency Magnetic Fields in the Management of Chronic Pain -- Manual Therapy Approach to the Extraocular Muscles in Migraine Treatment: A Preliminary Study -- Capacitive and Resistive Electric Transfer Therapy: A Comparison of Operating Methods in Non-specific Chronic Low Back Pain -- Serum Impedance in Children with Recurrent Respiratory Infections -- Olfactory Response to Altitude Hypoxia: A Pilot Study During a Himalayan Trek -- The Impact of Change in Hospital Admissions When Primary Care Is Provided by a Single Primary Care Physician: A Cohort Study Among HMO Patients in Israel -- Risk of Falls in Patients Aged Over 65 in the Context of the Treatment Facility -- Anthropometric Indices as Long-Term Predictors of Diabetes in Impaired Fasting Glucose Metabolism: Findings in the PURE Study in Poland -- Cardiovascular Risk Factors Drive Impaired Fasting Glucose to Type 2 Diabetes: Findings After a 9-Year Follow-Up in the PURE Study in Poland -- Sleep-Disordered Breathing in Pregnancy.
    Abstract: This book embraces a comprehensive range of research across several disciplines, providing insights and fresh perspectives on clinical topics, emphasizing the integrative medical approach. The book also addresses an increasing role of artificial intelligence in the development of clinical methodologies, research, and patient-oriented care. The authors share expertise and experience in rehabilitation medicine whose healing-effects particularly depend on the interaction between the therapist and patient. Chapters present novel approaches in manual rehabilitative therapy of common painful and disabling neuromuscular ailments, exemplified but not limited to low back pain and migraine. The myofascial trigger point release therapy includes specific manipulations to muscles and connective tissue which reduce pain. Other chapters address the issues of providing long-range medical care to older adults burdened with chronic diseases, notably hypoxia-related pathologies and their sequalae, pointing to the advantages of care provided by a single primary care physician. Changing paradigm of care is essential in chronic atherosclerosis-based diseases like cardiovascular disorders or diabetes. Chapters provide results of international cohort studies on predictive factors for the long-range progress of such ailments based on anthropometric and lifestyle indicators. The book aims to meet the increasing interest and importance to patients of integrative health therapies. Medical rehabilitation and lifestyle changes increasingly gain scientific support in difficult-to-treat chronic conditions and should be integrated in a controlled manner into conventional medicine. The book is addressed to physiotherapists, medical scientists and clinicians, and allied healthcare professionals.
    Type of Medium: Online Resource
    Pages: VI, 109 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030996307
    Series Statement: Clinical and Experimental Biomedicine, 1375
    DDC: 610.72
    Language: English
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  • 98
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Education Data processing. ; Image processing Digital techniques. ; Computer vision. ; Anatomy. ; Biomedical engineering. ; Computer simulation. ; Biomedical Research. ; Computers and Education. ; Computer Imaging, Vision, Pattern Recognition and Graphics. ; Anatomy. ; Biomedical Engineering and Bioengineering. ; Computer Modelling.
    Description / Table of Contents: Chapter 1. Creating Interactive Three-Dimensional Applications to Visualise Novel Stent Grafts That Aid in the Treatment of Aortic Aneurysms -- Chapter 2. Using Confocal Microscopy to Generate an Accurate Vascular Model for Use in Patient Education Animation -- Chapter 3. Methods and applications of 3D Patient-Specific Virtual Reconstructions in Surgery -- Chapter 4. Proof of Concept for the Use of Immersive Virtual Reality in Upper Limb Rehabilitation of Multiple Sclerosis Patients -- Chapter 5. Virtual Wards: A Rapid Adaptation to Clinical Attachments in MBChB During the COVID-19 Pandemic -- Chapter 6. Artificial Intelligence: Innovation to Assist in the Identification of Sono-anatomy for Ultrasound-Guided Regional Anaesthesia -- Chapter 7. A Systematic Review of Randomised Control Trials Evaluating the Efficacy and Safety of Open and Endoscopic Carpal Tunnel Release -- Chapter 8. Exploring Visualisation for Embryology Education: A Twenty-First-Century Perspective -- Chapter 9. How Artificial Intelligence and Machine Learning Is Assisting Us to Extract Meaning from Data on Bone Mechanics? -- Chapter 10. Visual Communication and Creative Processes Within the Primary Care Consultation -- Chapter 11. Digital 2D, 2.5D and 3D Methods for Adding Photo-Realistic Textures to 3D Facial Depictions of People from the Past -- Chapter 12. Teaching with Cadavers Outside of the Dissection Room Using Cadaveric Videos -- Chapter 13. A Novel Cadaveric Embalming Technique for Enhancing Visualisation of Human Anatomy -- Chapter 14. Assessing the Impact of Interactive Educational Videos and Screencasts Within Pre-clinical Microanatomy and Medical Physiology Teaching.
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings. The chapters presented in this volume cover such a diverse range of topics, with something for everyone. We present here chapters on 3D visualising novel stent grafts to aid treatment of aortic aneuryms; confocal microscopy constructed vascular models in patient education; 3D patient specific virtual reconstructions in surgery; virtual reality in upper limb rehabilitation in patients with multiple sclerosis and virtual clinical wards. In addition, we present chapters in artificial intelligence in ultrasound guided regional anaesthesia; carpal tunnel release visualisation techniques; visualising for embryology education and artificial intelligence data on bone mechanics. Finally we conclude with chapters on visualising patient communication in a general practice setting; digital facial depictions of people from the past; instructor made cadaveric videos, novel cadaveric techniques for enhancing visualisation of the human body and finally interactive educational videos and screencasts. This book explores the use of technologies from a range of fields to provide engaging and meaningful visual representations of the biomedical sciences. It is therefore an interesting read for researchers, developers and educators who want to learn how visualisation techniques can be used successfully for a variety of purposes, such as educating students or training staff, interacting with patients and biomedical procedures in general.
    Type of Medium: Online Resource
    Pages: XVI, 343 p. 163 illus., 153 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030877798
    Series Statement: Advances in Experimental Medicine and Biology, 1356
    DDC: 610.72
    Language: English
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  • 99
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Geology. ; Geotechnical engineering. ; Water. ; Geology. ; Geotechnical Engineering and Applied Earth Sciences.
    Description / Table of Contents: Introduction -- Evaluation of Groundwater Resources in West of the Nile Valley, Egypt: A Comprehensive Review -- Fundamentals of Groundwater Modeling Methods and a Focused Review on the Groundwater Models of the Nile Valley Aquifer -- Contamination Sources Along the Nile Valley, Egypt and Its Impact on Groundwater -- Environmental Impacts of Treated Wastewater Contaminates on Groundwater Quality in the Nile River Valley, Egypt.
    Abstract: Groundwater is the world’s largest source of fresh water, but its safe and sustainable exploitation remains a challenge. Egypt's Nile Valley aquifer is the most important renewable aquifer, accounting for approximately 85% of total groundwater use in Egypt. Egypt's long-term development and socioeconomic growth in the Nile Valley depends on this groundwater. Concerns about groundwater assessment, quality, management, and sustainability frame the current status of Nile Valley groundwater supplies. Proper knowledge of the current state of the groundwater quantity and quality in the Nile Valley is vital for the development and management of groundwater resources in Egypt. Due to Egypt's water scarcity, the projected decline in Nile River flow due to climate change, and the development of numerous Nile River basin projects, the situation is critical, and the consequences might be severe. Furthermore, Egypt's growing population puts significant strain on groundwater, which is the second most significant freshwater supply next to the surface water supply coming from the Nile River as Egypt’s share. Several books on the various aspects of Egypt's water resources have been published, but there is insufficient recent information on groundwater in the Nile Valley aquifer, which is essential for Egyptian populations for domestic and irrigation purposes. As a result, this book on the groundwater in the Nile Valley aquifer emerges to complete the picture of Egypt’s water resources as a good example of arid country located in MENA regions with many arid countries. Consequently, the lessons learned from this book could be beneficial to other countries in MENA regions, particularly those in North Africa.
    Type of Medium: Online Resource
    Pages: VIII, 354 p. 150 illus., 146 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031126765
    Series Statement: Earth and Environmental Sciences Library,
    DDC: 551.48
    Language: English
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  • 100
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geology. ; Water. ; Hydrology. ; Sedimentology. ; Earth sciences. ; Geography. ; Geology. ; Water. ; Sedimentology. ; Earth Sciences. ; Geography.
    Description / Table of Contents: Introduction -- Tectonic Setting of Cayman Islands -- Stratigraphic framework -- The Bluff Group -- The Ironshore Formation -- Modern marine sediments of the Cayman Islands -- Dolomitization of the Bluff Group -- Karst and caves -- Phosphates, terra rossa and mangrove peat -- Modern Hydrology -- Summary Information Database.
    Abstract: Grand Cayman, Little Cayman, and Cayman Brac are, in reality, the summits of independent fault blocks that rise from the depths of the Caribbean Sea. This book traces the geological evolution of these islands over the last 30 to 35 million years. The balance between deposition of carbonate sediments and karst development of the exposed land was dictated by the interaction between ever-changing sea levels and vertical tectonic movement of the fault blocks. Today, drinking water needed for the ever-increasing populations of the islands is supplied largely by desalinization plants that are located in accord with a detailed knowledge of the bedrock. This book is based on an extensive data base that has been assembled over the last 40 years of field work and laboratory analyses. Noteworthy aspects of this database include: Approximately 60 visits to the islands over last 40 years – sampling and documentation of virtually every accessible outcrop on the islands (including some that no longer exist). Most samples have been fully documented petrographically and geochemically. Data from 120 wells that have been drilled to depths up to 245 m (most less than 125 m). Wells have been cored and/or chip sampled. Full documentation of drilling histories, XRD analyses of samples, extensive geochemical analyses for major and minor elements, stable isotopes, 87Sr/86Sr ratios, and Rare Earth Elements from numerous samples. Mapping and sampling of modern sediments, including sediment cores, from most of the lagoons around Grand Cayman. Extensive thin section petrography, scanning electron microscope, and electron microprobe analyses of the dolostones and limestones that form the bedrock of the islands. Samples and data collected from numerous caves on Grand Cayman and Cayman Brac have been used to track their developmental history. Detailed analyses of phosphates collected from Little Cayman. Detailed analyses of terra rossa collected from each of the islands.
    Type of Medium: Online Resource
    Pages: XIII, 291 p. 247 illus., 232 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031082306
    DDC: 551
    Language: English
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