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  • Nature Publishing Group  (64,073)
  • Annual Reviews
  • 2005-2009  (17,092)
  • 1990-1994  (23,842)
  • 1980-1984  (21,818)
  • 1945-1949  (14,746)
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  • 1
    Electronic Resource
    Electronic Resource
    Maintenance of Professional Standards (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1101-1104 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE ostensible theme of Viscount Samuel's lecture* to thalfetienal Book League in November 1948 was JJiat thAySommumty could be more active now in epiai^iftjaleisure and the opportunities for its ria(i2Vusft.J T)uringihe year that has since passed, sctnMpf Pus obsenfi}|ons have gained in force. ...
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    URL: http://dx.doi.org/10.1038/1641101a0
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  • 2
    Electronic Resource
    Electronic Resource
    A philosophy of science (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1104-1104 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SINCE 19*5 onejpf the features of the scientific life of Great "Britain has been a growing interest in the 'philSfipphjief science'. The Philosophy of Science Group or wie VBritish Society for the History of Sciejwe waiJ formed in 1948 with the express object of fcryg'ing together those men of ...
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  • 3
    Electronic Resource
    Electronic Resource
    The Science of Tsetse Control (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1114-1115 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] TSETSE control should never be divorced from research, ^h^ugh it may fall into the two categorieslona-rahge and applied. Long-range control is devoted^Jfc〉' the extermination of tsetse, whether concerns, with the transmission of trypanosomiasis or »at. .Like pure research, it has great ...
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    URL: http://dx.doi.org/10.1038/1641114a0
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  • 4
    Electronic Resource
    Electronic Resource
    Quantum Mechanics (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1105-1105 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE author writes in the preface to this book: The book is intended to serve as a text on the gramiaTO level and also as a reference book". It is difficult to do both these things well. A reference book has to be reasonably complete, and the author has little freedom in the choice of material. In ...
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  • 5
    Electronic Resource
    Electronic Resource
    Dr. R. A. Hull (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1116-1117 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DB. R. A. HuLL was killed at the age of thirty-eight when We fell while climbing the Brouillard ridge of Mont JS^nc on August 22. Going up to Oxford in 19^9 V^an exhibitioner of St. John's College, he obt|mea a first class in Physics Finals in 1932 and was (Sected a senior scholar of Christ Church ...
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  • 6
    Electronic Resource
    Electronic Resource
    Bird Photography by High-speed Electronic Flash (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1118-1118 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A METHOD of taking bird photographs which promises tcibp of great value in the analysis and understanding of bird flight has been described by Eric Hoskuig (British Birds, 42, No. 8; August 1949). SDfe high-speed electronic flash is many times brighter\han bright sunlight and is usually arranged to ...
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    URL: http://dx.doi.org/10.1038/1641118b0
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  • 7
    Electronic Resource
    Electronic Resource
    The Night Sky in January (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1119-1119 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] FULL moon occurs on Jan. 4d. 07h. 48m., TJ.T., and new moon on Jan. 18d. 07h. 59m. The following conjunctions with the moon take place:Jan. 9flmn.", Saturn 0-2° N.; Jan. lOd. 10h., Mars 2° N.; Jan. 19d. 14h., Venus 10° N. In addition to these conjunctions with the moon, Venus is in conjunction with ...
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  • 8
    Electronic Resource
    Electronic Resource
    Sheld-Ducks: Migration In Summer (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1122-1123 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE status of JwTcommon sheld-duck, Tadorna tadoma (L.),i^ Great Britain and Ireland has long been descfifa0i in the ornithological literature as being simila* toWhat of other British breeding ducks, namely, a resident species the numbers of which are increaseftjiby immigrants from the continent of ...
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    URL: http://dx.doi.org/10.1038/1641122a0
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  • 9
    Electronic Resource
    Electronic Resource
    Forthcoming Events (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1139-1139 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Monday, January 2 INSTITUTION OF GINEERS (at Great George Street, London, 0. W. Knight:"The Building o: S.W.I), at 3 (Christmas of Dams'' Boys). Tuesday, January 3 SOCIETY OF PUBLIC ANALYSTS AND OTHER ANALYTICAL CHEMISTS, PHYSICAL METHODS GROUP (in the Chemistry Lecture Theatre, Imperial College ...
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  • 10
    Electronic Resource
    Electronic Resource
    Sir Philip Hartog (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1063-1063 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE publication of this excellent and well-written bij[^tophical memoir of the late Sir be welcomed by all who knew ? ??t??????^G, and no less by that far greater number wrA/krfew' his work in one or other of the many fieraj in which he achieved distinction. The opening chapter recalls a bygone ...
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  • 11
    Electronic Resource
    Electronic Resource
    [Book Reviews] (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1066-1066 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MESSRS. E. F. RICKETTS and J. Calvin have revised their well-known book on the littoral fauna of the west coast of America. Written by laymen collec*prs£|)*f the layman, it stimulates his curiosity aboul iune prolific life of the sea-shore and deals witrhe^Subject from the ecological rather than ...
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    URL: http://dx.doi.org/10.1038/1641066b0
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  • 12
    Electronic Resource
    Electronic Resource
    Groundnut Scheme In East Africa (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1067-1068 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] READING the first annual report and accounts for 1948-49 of the Overseas Food Corporation*, the reader gets \juft impression that the high hopes with whicX JttjeiEast African groundnut scheme was laun0J?ecMa,Qifd rapidly. Certainly, not only the hopes but ^ijjfee thy scheme itself would have gone ...
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  • 13
    Electronic Resource
    Electronic Resource
    International Council for the Exploration of the Sea (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1072-1073 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ON the invitation of the British Government, the International Council for the Exploration of the Sea (Conseil Permanent International pour 1'Explora-tion de la Men arranged to hold its thirty-seventh annual naee^in^ttrEdinburgh during October 311. The occasipn-jpas the more welcome since it was ...
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  • 14
    Electronic Resource
    Electronic Resource
    [Obituaries] (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1076-1076 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WE regret to announce the following deaths: Mr. W. E. Copleston, C.S.I., formerly chief conservator of forests, Bombay, on December 1. Prpf. Rene Maire, professor of botany in the University of Algiers, one of the twelve non-resident members of the Paris Academy of Sciences, on November 24, aged ...
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  • 15
    Electronic Resource
    Electronic Resource
    Prof. T. Slater Price, F.R.S. (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1116-1116 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] PROF. THOMAS SLATER PRICE was born on August 24, 1875, and died on OcMier 29, 1949. Educated at King Edward's Hig4'i$3hool, Birmingham, he proceeded to Mason Collage, Birmingham, and graduated with first-class flonours in chemistry and physics at the University or London in 1895. In that year he ...
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  • 16
    Electronic Resource
    Electronic Resource
    Middle East Oil (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1118-1118 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN an article in Volume 31, No. 1, of The Lamp (house journalojKthe Standard Oil Co., New Jersey, published fiTeiimes a year primarily for employees and stodolaers) a survey is made of progress in oil production during the past fifty years in the Middle EaatA During that time production increased ...
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  • 17
    Electronic Resource
    Electronic Resource
    Announcements (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1119-1119 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] AN exhibition, entitled "Research and Production" is to be held by the British Welding Research Associatipriat its London headquarters at 29 Park Cresceirtf, London, W.I, during February 7-11, bejbween 10 a.m. and 5.30 p.m. THE forty-seventh exhibition of scientific instruments anjef materials, ...
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  • 18
    Electronic Resource
    Electronic Resource
    Prof. C. A. Bentley, C.I.E. (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1116-1116 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN the death oft Prof C. A. Bentley, tropical sanitation an.ent and zealous worker and on malaria. In his early .tley made many contributions to ', including recognition of the cause coolie labour as due to penetration ankylostome larvae and the finding of the Leishman-Donovan bodies in kala azar, ...
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  • 19
    Electronic Resource
    Electronic Resource
    Sugar Research Foundation (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1125-1126 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ANNUAL REPORT THE Sugar ResajArch Foundation, which is an organisation fltnprted by the great majority of both cane- andjubeefilmagar producers and refiners Of United StatesVerritories, has recently issued its sixth annual.repprt. This document, prepared by the sciantifB^director, Dr. Robert C. ...
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  • 20
    Electronic Resource
    Electronic Resource
    Periods and Eccentricities of Close Binary Stars (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1129-1130 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] EXAMINATION of the material in the Fifth Lick Catalogue of spectroscopic binaries, recently published by Moore and Neubauer1, reveals a definite relation between periods of revolution P and eccentricities of orbits e for binaries with short periods if their components belong to ...
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  • 21
    Electronic Resource
    Electronic Resource
    Crystal Structure of Hollandite (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1128-1128 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] HOLLANDITE, cryptomelane, coronadite and α-MnO2 form an isostructural series of the general formula A2−yB8−zX16, A being large ions such as Ba2+, Pb2+ and K+, B small and medium-sized ions ...
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  • 22
    Electronic Resource
    Electronic Resource
    A New Method for the Separation of Hydrocarbons by Selective Adsorption (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1132-1133 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE separation of hydrocarbons can be effected by different methods, for example, crystallization, distillation and solvent treatment. A particular type of the last method is that of fractional precipitation from solution in light hydrocarbons such as propane by the use of methane and other ...
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  • 23
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    Electronic Resource
    Estimation of ‘Hetrazan’ in Body Fluids (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1135-1135 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE estimation of ‘Hetrazan’ (1-diethylcarbamyl-4-methyl piperazine hydrochloride), which has been recently introduced for the treatment of human fllariasis due to Wüchereria bancrofti1, may be carried out by a ‘dye-laking’ method, similar in principle to the methods developed ...
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  • 24
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    Growth-Cycle of Influenza Virus (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1137-1138 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] FULTON has criticized1 my work on the growth-cycle of influenza virus2; he appears to have confirmed the main facts, but is reluctant to accept the conclusions. The essential facts are these. (1) Extracts of tissue infected with influenza virus contain two ...
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  • 25
    Electronic Resource
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    Exchange of Oxygen-18 Between Oxides and Gaseous Oxygen (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1130-1131 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE communication by J. A. Allen and I. Lauder1 is of interest to us since we are also making an examination of such reactions. It was anticipated that this work would throw some light on the nature and reactivity of solids and solid surfaces; this expectation has been ...
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  • 26
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    Reports and other Publications (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1139-1140 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Great Britain and Irelandmdon University College. Calendar, Session r.,Jtxvii + 596. (London: Taylor and Francis, Ltd., 1949.)"., r [1010 PlanVfing a Visual Education Policy. Report of the National Committee for Visual Aids in Education (1948); together with Recommenda tions for Future ...
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  • 27
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    Microwave Aerials (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1064-1065 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THESE books are two further volumes of the comprehensivA^eies on radar and related techniques prepaied ajjjine Radiation Laboratory of the MassachusettsSAfttitute of Technology. Readers of these epho^nfr1 will already be aware of the general scope Mid" aim of this series from earlier reviews of ...
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  • 28
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    British Vegetation (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1063-1064 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] BY the laymah the preservation of the flora and fauna is Ce^'often regarded as the concern of the man of sc〉OT.3e alone, since the contribution that the and animal life make to his enjoyment entirely unapprehended or only vaguely aj?pTeciated. A wider knowledge by the general public the nature ...
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  • 29
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    Supersonic Aerodynamics (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1104-1105 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] JUST before the outbreak of war in 1939, Dr. Ferri Jkjwaslin charge of the supersonic wind tunnel at GtUdonm, near Rome, then by far the largest in the world. There he made some fundamental experiments, now classical, to determine how far the theories of the Gottingen school, led by Prandtl and ...
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  • 30
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    Separation of the Phosphoric Esters on the Filter Paper Chromatogram (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1107-1112 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] PHOSPHORIC esters play a central part in the biological world bY linking processes of respiration and fermentation with other essential cellular reactions. ??-T Vnan twenty substances of this group, maiujy sftgars and related substances esterified with_phospi*6ric acid, are known to form ...
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  • 31
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    United Nations Research Laboratories (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1120-1121 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN October 1946 the Economic and Social Council of the Unitedvftftions adopted by a large majority a resolution .Unitted by the French delegation calling with tff ae Secretary-General, in consultation ffu(functional, Scientific and Cultural Organ-the other specialized agencies concerned, upon the ...
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  • 32
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    Agricultural Attaché to the British Embassy in Buenos Aires (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1118-1118 
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    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MR. A. G. MiLL has been appointed to succeed Major T. A. Ratway as agricultural attache to the British Embassy in Buenos Aires. Mr. Mill, who is forty-one, has hefen connected with farming all his life, mainly witjr cattle, sheep and horses. From 1928 he was for ton years in the Argentine as an ...
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    Colonial Service: Recent Appointments (1949)
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    Nature 164 (1949), S. 1118-1119 
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    Notes: [Auszug] THE following appointments in the Colonial Service have been/recently announced:D. J. O. Burke, A. G. Cullum/and A. A. Kingshotte, agricultural officers, Nigeria; I. Constantinesco and A. Hamersley, agri-cultm-al officers, Tanganyika; J. H. Rhodes and A/T. Wilson, agricultural officers, Northern ...
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    Forest Research in Sweden (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1126-1126 
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    Notes: [Auszug] THE reports of the Forest Research Institute of J. Sweden for 1948-49* contain some interesting articles, among whjflHmay be mentioned:"Solid volume in staked pulpwood of pine and spruce (length of fesjpks Jand 3 metres) and the volume of solid rouA wo6^J'(with bark) in relation to stacked ...
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    Response of Plasmodium berghei to Anti-malarial Drugs (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1133-1133 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE discovery of Plasmodium berghei by Vincke and Lips1 has provided a valuable new strain of malaria for the laboratory trials of chemotherapeutic drugs. We are grateful to Prof. H. E. Shortt for presenting us with a strain of this organism, which we have used for the ...
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    Assay of the Nutritive Value of a Protein by its Effect on Liver Cytoplasm (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1136-1136 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] THE fact that the cytoplasm content of the liver cell is determined by the quality and quantity of the dietary protein has recently been utilized for the assay of the nutritive value of a protein1. A measure of the cytoplasm content of the liver cell was obtained by estimating ...
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    Mass Therapy with ‘Hetrazan’ as a Control Measure for Bancroftian Filariasis on St. Croix, American Virgin islands (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1135-1136 
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    Notes: [Auszug] IN the spring of 1948 a mass treatment programme with ‘Hetrazan’ was conducted on the island of St. Croix, with the object of reducing microfilaræmia in persons infected with Wüchereria banorofti to sub-infective levels for mosquitoes. A survey of 977 people of all age groups revealed an ...
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    [Book Reviews] (1949)
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    Nature 164 (1949), S. 1066-1066 
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    Notes: [Auszug] THE principilysfciinge in this valuable work for the ge'neeqi 'reader is the change in size from quarto il a/rormat which allows it to be shelved with the/Tnajp?ity//of other reference books. It is compiled onfSjhe plan of the 'dictionary catalogue', and the eross^references increase its value in ...
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    Prof. Alfred S. Barnes (1949)
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    Nature 164 (1949), S. 1075-1075 
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    Notes: [Auszug] THE death on November 11 of Alfred S. Barnes removes another survivor of a former generation of the teachers of the Manchester Municipal School of Technologyi: most have passed away. The School-then the largest and best equipped in Great Britain was opened in 1902; Barnes was appointed in 1901 as ...
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    Food and Agriculture Organisation: Statistics Officer in the Far East (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1076-1076 
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    Notes: [Auszug] THE Economics and Statistics Division of the United Nations Food and Agriculture Organisation has appointed Mr. C. P. G. J. Smit to be regional representative for statistics in Asia and the Far East. Mr. Smit, who has been with the Netherlands Government for twenty-one years, was formerly deputy ...
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    Trotter and Paterson Memorial Lectures of the Illuminating Engineering Society (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1117-1118 
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    Notes: [Auszug] THE Council of the Illuminating Engineering Society is raisinapa fund to provide for public lectures in memory ofJihe late Mr. A. P. Trotter and the late Sir Clifford/Paterson. It has been suggested that the money should be contributed in small sums from the whefle membership of the Society, and ...
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    Source of the Cosmic Rays (1949)
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    Nature 164 (1949), S. 1112-1114 
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    Notes: [Auszug] THE enormous energy possessed by the cosmic rays hasttswren rise to many speculations as to how theyfpoufi be generated, which have gone deep into the ijiLperties of the ultimate particles, and into the dismpution of matter in outer space1. The purpose of the present note is to direct attention to ...
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    Pleistocene Deep Weathering (1949)
    [s.l.] : Nature Publishing Group
    Nature 164 (1949), S. 1130-1130 
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    Notes: [Auszug] T. C. Phemister and S. Simpson have performed a very useful service in recording deep weathering of granite under comparatively unweathered glacial deposits, as exposed during the cutting of a new drainage system in Aberdeen city1. They refer to other examples of the same kind, ...
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    Fifty Years Of Genetics (1949)
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    Nature 164 (1949), S. 1124-1125 
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    Notes: [Auszug] THE Genetitical Seociety of Great Britain held its hundredth meeting in Cambridge during June also the thirtieth anniversary of the SocietylYounded by William Bateson in 1919, and the meelmg was intended to be one with time and, pos^feJy, atmosphere for taking stock of the past And_ locking at the ...
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    Rate of Self-Diffusion in Tin Crystals (1949)
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    Nature 164 (1949), S. 1127-1128 
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    Notes: [Auszug] IN non-cubic crystals the rate of self-diffusion can be expected to depend on the crystallographic direction parallel to which the diffusion is measured. Although the determination of this anisotropy is of interest for the theory of diffusion, experiments have so far only been carried out on ...
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    Position of ‘Luxate’ in the Third Linkage Group of the House Mouse (1949)
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    Nature 164 (1949), S. 1138-1138 
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    Notes: [Auszug] THE occurrence of a new strain of mice (Mus musculus, L.) resembling the extinct souris luxées of Rabaud1 has been reported2; these mice show extensive abnormalities of the hind limbs, including absence of the tibia (hemimelia). The condition was found to be due to ...
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    Melanin Solubility in Tissue Sections (1949)
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    Nature 164 (1949), S. 1133-1134 
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    Notes: [Auszug] QUANTITATIVE estimations of staining reactions and histochemical observations on melanomas are not readily made because cellular detail is often obscured by melanin granules. One of the most promising solvents for melanin is ethylene chlorohydrin1. This solvent, and others ...
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    Pregnancy Test using Male Toads (1949)
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    Nature 164 (1949), S. 1138-1138 
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    Notes: [Auszug] STARTING in November 1948, a series of tests1 for pregnancy were performed using the native male toad, Bufo melanostictus Schneid. Specimens of urine from women pregnant from six weeks to seven months were used. In each series, two or more experimental toads were used. Controls ...
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    Appointments Vacant (1949)
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    Nature 164 (1949), S. 1139-1139 
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    Notes: [Auszug] APPLICATIONS are invited for the following appointments on or before the dates mentioned: ASSISTANT BIOCHEMIST (with degree or equivalent qualification in chemistry tfrshlMto take up clinical biochemistry)-The Secretary, Welsh H«wola| School of Medicine, 34 Newport Road, Cardiff LBDBURER IN ...
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    A short linear peptide that folds into a native stable β-hairpin in aqueous solution (1994)
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    Nature structural biology 1 (1994), S. 584-590 
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    Notes: [Auszug] The conformational properties of a 16 residue peptide, corresponding to the second β-hairpin of the B1 domain of protein G, have been studied by nuclear magnetic resonance spectroscopy (NMR). This fragment is monomeric under our experimental conditions and in pure water adopts a population ...
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    Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor (1994)
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    Nature structural biology 1 (1994), S. 605-614 
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    Notes: [Auszug] The solution structure of the DNA-binding domain of the Drosophila heat shock transcription factor, as determined by multidimensional multinuclear NMR, resembles that of the helix-turn-helix class of DNA-binding proteins. The domain comprises a four-stranded antiparallel β-sheet, packed ...
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    Mutational analysis of the DNA-binding domain of yeast heat shock transcription factor (1994)
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    Nature structural biology 1 (1994), S. 615-620 
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    Notes: [Auszug] Both randomized oligonucleotide cassette mutagenesis and site-directed mutagenesis have been used in combination with a yeast genetic screen to identify critical residues in the DNA-binding domain of heat shock transcription factor from Saccharomyces cerevisiae. Most of the surface residues in this ...
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    Structure of a pertussis toxin–sugar complex as a model for receptor binding (1994)
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    Nature structural biology 1 (1994), S. 591-596 
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    Notes: [Auszug] Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis which is important the pathogenesis of whooping cough and the generation of a protective immune response. The diverse biological activities of the toxin depend on its ability to recognize carbohydrate-containing receptors on a ...
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    In vitro splicing of concanavalin A is catalyzed by asparaginyl endopeptidase (1994)
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    Nature structural biology 1 (1994), S. 502-504 
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    Notes: [Auszug] Sir — Protein splicing1,2 modifies the polypeptide chain of a gene product by excision of intervening sequence(s) and religation of the remainder. An early example was found during the post-translational processing of concanavalin A (Con A) in maturing jackbeans3,4. This takes an unusual ...
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    Structural compensation in atypical mitochondrial tRNAs (1994)
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    Nature structural biology 1 (1994), S. 507-510 
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    Notes: [Auszug] Sir — The sequences of many animal mitochondrial tRNAs (mtRNAs) are perplexing in that they display both primary and presumed secondary structural patterns which deviate significantly from the norm as defined by several highly conserved nucleotides and the cloverleaf structure1. As some of ...
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    A tale of two proteinases (1994)
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    Nature structural biology 1 (1994), S. 492-494 
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    Notes: [Auszug] Structural biologists have long realised that nature is subtle rather than simple. The classification of proteolytic enzymes — which once seemed so clearcut — into cysteine, serine, aspartate and zinc proteinases was previously complicated by the finding that the subtilisins had ...
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    Erratum: Groovy Water (1994)
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    Nature structural biology 1 (1994), S. 557-557 
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    Notes: [Auszug] The structure of the trp repressor/operator complex caused something of a stir when it was published over five years ago. Of the four base-specific hydrogen bonds between a repressor monomer and operator DNA, three are indirect, being mediated through water molecules: a thoroughly unexpected result ...
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    Signalling an interest (1994)
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    Nature structural biology 1 (1994), S. 417-420 
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    Notes: [Auszug] Since their discovery in 19861, Src Homology 2 (SH2) domains have attracted enormous attention from the fields of cell biology, biochemistry and structural biology. As a result, we now have a much more detailed picture of the function, structure and ligand specificity of this 100 amino acid protein ...
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    2.2 Å structure of oxy-peroxidase as a model for the transient enzyme: peroxide complex (1994)
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    Nature structural biology 1 (1994), S. 524-531 
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    Notes: [Auszug] The Fe+3-OOH complex of peroxidases has a very short half life, and its structure cannot be determined by conventional methods. The Fe+2-O2 complex provides a useful structural model for this intermediate, as it differs by only one electron and one proton from the transient Fe+3-OOH complex. We ...
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    The metal-ion-free oxidoreductase from Streptomyces aureofaciens has an α/β hydrolase fold (1994)
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    Nature structural biology 1 (1994), S. 532-537 
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    Notes: [Auszug] The crystal structure of the bromoperoxidase A2 from Streptomyces aureofaciens (ATCC 10762) has been determined by isomorphous replacement and refined to 2.05 Å resolution with an R-value of 18.4%. The enzyme catalyzes the bromination of organic compounds in the presence of bromide and ...
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    Erratum: A measure of helical propensity for amino acids in membrane environments (1994)
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    Nature structural biology 1 (1994), S. 558-558 
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    Notes: [Auszug] Nature Structural Biology 1, 368–373 (1994). The abstract and Table 1 were printed with a number of typographical errors which are corrected in the version below. The frequent occurrence of β-sheet promoting residues such as Ile, Val, and Thr in the α-helical transmembrane ...
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    The evolution of oligomerization (1994)
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    Nature structural biology 1 (1994), S. 411-412 
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    Notes: [Auszug] What are the mechanisms that underlie the evolution of protein form? Although the details of intra- or intermodular interactions are often moulded by gradual change involving individual residues, there is much evidence indicating that the overall architecture of a polypeptide chain is formed by the ...
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    Loopy similarities (1994)
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    Nature structural biology 1 (1994), S. 421-422 
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    Notes: [Auszug] Sir—Using global structure comparisons, Holm et all have identified a superfamily of three NAD(P) linked oxidoreductases; dihydropteridine reductase (DHR)2, UDP galactose-4-epimerase (UDP)3 and 3α, 20βhydroxysteroid dehydrogenase (HSD)4. They also suggest that apart from a common ...
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    Entropic effects of disulphide bonds on protein stability (1994)
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    Nature structural biology 1 (1994), S. 434-438 
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    Notes: [Auszug] To measure the thermodynamic consequences of the reduction in the number of polypeptide-chain conformations that accompanies protein folding, we developed a method called loop permutation analysis. In this approach, the stabilizing contributions of three engineered disulphide bonds were compared in ...
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    2.1 Å structure of Serratia endonuclease suggests a mechanism for binding to double-stranded DNA (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 461-468 
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    Notes: [Auszug] The crystal structure of Serratia endonuclease has been solved to 2.1 Å by multiple isomorphous replacement. This magnesium-dependent enzyme is equally active against single- and double-stranded DNA, as well as RNA, without any apparent base preference. The Serratia endonuclease fold is ...
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    Zinc mining for protein domains (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 345-349 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Scientific exploration has always progressed in fits and starts. As new themes are exposed these often become ‘fashionable’ and so for a time develop into focal points for further research by large numbers of scientists. In this way the discovery in 1985 of the ‘zinc-finger ...
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    Direct evidence for the role of haem doming as the primary event in the cooperative transition of haemoglobin (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 230-233 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The study of cooperative ligand binding among the four subunits of haemoglobin has played a central role in the understanding of allosteric transitions in a large number of enzymes. Haem iron out-of–plane motion has been suggested to be the trigger for the cooperative transition of ...
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    Are there knots in proteins? (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 213-214 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Sir — Most biochemists would probably agree that proteins in the native state are not knotted. The protein folding mechanism is not perceived as including reptative, snake-like motions of the chain along its own contour. However, reptation would be necessary for the protein to knot itself. ...
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    Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 221-225 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Src homology 3 (SH3) domains bind specific proline-rich peptide motifs. To identify interactions involved in peptide recognition, we have mutated residues on the putative binding surface of an SH3 domain from the Caenorhabditis elegans protein Sem-5. Among the most critical positions are three ...
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    Signal transduction versus buffering activity in Ca 2+ –binding proteins (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 239-245 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The three–dimensional structure of calbindin D9k in the absence of Ca2+ has been determined using NMR spectroscopy in solution, allowing the first direct analysis of the consequences of Ca2+ binding for a member of the calmodulin superfamily of proteins. The overall response in calbindin D9k ...
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    A happy diversity of interactions (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 129-130 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The 1990s have seen a significant expansion of the lexicon of structural motifs in proteins known to interact with DNA, as well as an ever-increasing wealth of detail about previously characterized DNA-binding domains. And the first quarter of 1994 has not been a disappointment; papers in this1 and ...
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    Three sisters, different names (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 146-147 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Sir — The classical NAD binding fold, as seen in lactate dehydrogenase or liver alcohol dehydrogenases, consists of six strands of parallel β-pleated sheet flanked on either side by α-helices, with ∼100 structurally conserved residues1. Here, we report a novel subclass of ...
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    The barriers in protein folding (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 149-156 
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    Notes: [Auszug] Elimination of an interaction which forms in denatured cytochrome c enables the majority of the molecules to fold to the native state on a 15 ms time scale, without populating observable intermediates. These results are contrary to the current view that particular steps in protein folding, ...
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    T and R states in the crystals of bacterial L–lactate dehydrogenase reveal the mechanism for allosteric control (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 176-185 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The crystal structure of L–lactate dehydrogenase from Bifidobacterium longum, determined to 2.5 Å resolution, contains a regular 1:1 complex of T– and R–state tetramers. A comparison of these two structures within the same crystal lattice and kinetical characterization of ...
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    The NMR structure of the inhibited catalytic domain of human stromelysin–1 (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 111-118 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The three–dimensional structure of the catalytic domain of stromelysin–1 complexed with an N–carboxyl alkyl inhibitor has been determined by NMR methods. The global fold consists of three helices, a five stranded β–sheet and a methionine located in a turn near the ...
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    Metalloproteinase super–families and drug design (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 73-75 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] As the process of drug discovery focuses on structure-based design, the small number of available three-dimensional structures compared to the wealth of gene sequences becomes an increasing frustration. One solution to the paucity of structural information is to search for proteins with a common ...
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    From protoxin to pore (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 80-80 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A model of the oligomeric form of the bacterial toxin aerolysin from Aeromonas hydrophila that inserts into the membranes of ill-fated host cells is shown on the right — taken from Parker et al., Nature 367, 292–295 (1994). The seven toxin monomers that make up the proposed channel are ...
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    Human telomeric C–strand tetraplexes (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 83-88 
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    Notes: [Auszug] Telomeric C–strand sequences form non–Watson–Crick base–paired structures in supercoiled plasmids and in oligonucleotides at low pH. Here we examine oligonucleotides composed of 2 or 4 repeats of the human telomeric C–strand sequence d(CCCTAA)n. At low pH, the ...
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    2–Aminofluorene modified DNA duplex exists in two interchangeable conformations (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 89-94 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] One– and two–dimensional NMR shows that the carcinogen 2–aminofluorene exists in two unique, interchangeable conformations when covalently bound to a model human c–H–ras1 proto–oncogene codon 61 oligomer duplex. In one conformation the 2–aminofluorene ...
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    That was the year that was (1994)
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    Nature structural biology 1 (1994), S. 833-834 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The disparate structural themes that have caught the imagination of readers of this, and other journals over the last year provide an apposite illustration of the ever widening impact of structural biology on the efforts of scientists to understand the workings of the cell and the molecular ...
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    A conserved loop in the ATPase domain of the DnaK chaperone is essential for stable binding of GrpE (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 95-101 
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    Notes: [Auszug] The activity of DnaK (Hsp70) chaperones in assisting protein folding relies on DnaK binding and ATP–controlled release of protein substrates. The ATPase activity of DnaK is tightly controlled by the nucleotide exchange factor GrpE. We find that GrpE interacts stably with the ...
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    Ribozyme revealed (1994)
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    Nature structural biology 1 (1994), S. 846-849 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] In discussing the genetic code in 1966 Crick proposed that tRNA was “Nature's attempt to make an RNA play the role of a protein“1.The sub- sequent X-ray crystal structure de terminations of tRNAs showed Crick's hypothesis to be correct. Pley, Flaherty and McKay now present the structure ...
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    Solution structure of the ets domain of Fli-1 when bound to DNA (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 871-876 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Members of the ets family of transcription factors share a conserved DNA-binding domain, the ets domain. By using multidimensional NMR, we have determined the structure of the ets domain of human Fli-1 in the DNA-bound form. It consists of three α-helices and a four-stranded β-sheet, ...
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    NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 898-907 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] GRB2 is a small adaptor protein of 217 amino acids comprising one SH2 domain surrounded by two SH3 domains. GRB2 couples receptor tyrosine kinase activation to Ras signalling by interacting, through its SH3 domains, to the carboxy-terminal proline-rich regions of the guanine nucleotide exchange ...
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    Structural conservation of hypervariable regions in immunoglobulins evolution (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 915-920 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Analysis of human and mouse immunoglobulins has shown that five of six hypervariable regions that form the antigen binding site have a small repertoire of main chain conformations (canonical structures). Cartilaginous fishes are the most distantly related species to humans known to have an immune ...
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    Structure determination of racemic trichogin A IV using centrosymmetric crystals (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 908-914 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Direct methods of crystal structure solution are greatly facilitated in centrosymmetric space groups where the complexity of the phase-problem is reduced. For most peptides and proteins, crystallization in a centrosymmetric arrangement is precluded by an intrinsic dissymmetry due to the constituent ...
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    Casting a cold eye over myoglobin (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 749-751 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Two recent X-ray crystallographic studies describe the location of carbon monoxide in myoglobin (Mb) following its photodissociation from the haem iron12 This photochemical intermediate, denoted Mb*CO, is short-lived under physiological conditions and leads to conformational relaxation of the ...
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    Mediating intracellular communication (1994)
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    Nature structural biology 1 (1994), S. 747-748 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Being able to respond to the environment is vital for all cells, be they free-living unicellular organisms or the constituents of tissues that make up multicellular plants and animals. Indeed, there are suggestions that the 2.5 billion years it took for multicellular organisms to appear may have ...
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    Probing G-protein function (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 752-754 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Heterotrimeric GTP-binding proteins (G-proteins) mediate transduction of various signals (hormones, neurotransmitters, light, smell, taste, and so on) from cell surface seven-helical transmembrane receptors to their intracellular effector targets. Thus G-proteins are positioned as key elements that ...
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    More meanders and sandwiches (1994)
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    Nature structural biology 1 (1994), S. 755-757 
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    Notes: [Auszug] An essential requirement of any cell is its ability to respond to the surrounding environment. Batteries of receptors intercept the multitude of signals which continually bombard the cell surface. This information must then be processed and an appropriate cellular response formulated, be it growth, ...
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    Evolutionary implications (1994)
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    Nature structural biology 1 (1994), S. 760-760 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] In reply: The fact that BirA and Class II aminoacyl-tRNA synthetases have a topologically equivalent fold for their catalytic domains is of great interest from an evolutionary point of view. Unlike Class I synthetases–which have the widespread, dinucleotide binding (Rossmann) fold for their ...
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    If the coat fits… (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 764-764 
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    Notes: [Auszug] Unlike the DNA-binding proteins, a large number of whose structures have been determined, little is known about the detail of sequence-specific interactions between proteins and RNA. To date the only high resolution structures of sequence-specific protein/RNA complexes have been those of tRNA ...
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    Addendum (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 828-828 
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    Notes: [Auszug] Sir — May I draw your readers' attention to three more important contributions which I omitted from my obituary of Linus Pauling (Nature Structural Biology, 1, 667–671): Part of Pauling's PhD thesis was on the structure of the mineral molybdenite (MoS2), which he determined by X-ray ...
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    Erratum: The structure of avian eye lens δ-crystallin reveals a new fold for a superfamily of oligomeric enzymes (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 831-831 
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    Notes: [Auszug] A. Simpson, O. Bateman, H. Driessen, P. Lindley, D. Moss, S. Mylvaganam, E. Narebor and C. Slingsby Nature structural Biology 1, 724–734. Table 1 was unfortunately omitted. Table 1 Phasing statistics Date set Resolution Completeness Multiplicity Rsym Riso Mean phasing power acentric Mean ...
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    Being direct (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 679-679 
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    Notes: [Auszug] Recent years have seen an explosion in the number of X-ray structures for protein-DNA complexes. Many of these structures feature water molecules buried at the intermolecular interface. Otherwise unaccounted for electron density at an interface can be assigned with reasonable confidence as a water ...
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    Crystallographic observation of a trapped tetrahedral intermediate in a metalloenzyme (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 691-694 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Formation of tetrahedral transition intermediates is a key step in many enzyme catalyzed reactions. Much of our understanding of these and other intermediates, at the atomic level, has come from crystallographic studies of very few enzymes with bound, synthetic, transition-state analogues. Here we ...
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    Prediction of new serine proteinase inhibitors (1994)
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    Nature structural biology 1 (1994), S. 735-743 
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    Notes: [Auszug] We describe here the use of a rapid computational method to predict the relative binding strengths of a series of small-molecule ligands for the serine proteinase trypsin. Flexible molecular models of the ligands were docked to the proteinase using an all-atom potential set, without cutoff limits ...
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    Specific purine N 7 -nitrogens are critical for high affinity binding by the trp repressor (1994)
    [s.l.] : Nature Publishing Group
    Nature structural biology 1 (1994), S. 18-22 
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    Notes: [Auszug] We have analysed the interaction of the trp represser with the trpEDCBA operator using a series of modified trp operator sequences incorporating two isosteric purine analogues that lack N7–nitrogens. Our results suggest that as well as the direct contact between Arg69 and G−9, three ...
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    The rise and rise of a structural technique (1994)
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    Nature structural biology 1 (1994), S. 578-579 
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    Notes: [Auszug] NMR of Proteins Edited by G M Clore and A M Gronenborn. Macmillan, Houndmills, Basingstoke, Hampshire RG21 2XS, UK (distributed in the U.S.A. by CRC press Inc., 2000 Corporate Boulevard NW, Boca Raton, Fl 33631): 1993 306 pages. £ 70.00; $97.00 The very existence of this journal is a ...
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    A single methyl group prevents the mischarging of a tRNA (1994)
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    Nature structural biology 1 (1994), S. 580-582 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Sir — Because of the structural similarity of tRNAs, expression of their aminoacylation identity1,2 requires rejection of non-cognate tRNAs by aminoacyl-tRNA synthetases. It has been shown with yeast tRNAAsp that negative discrimination prevents its mischarging by arginyl-tRNA synthetase ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nsb0994-580
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