ISSN:
1573-8744
Schlagwort(e):
protein binding
;
organic acids
;
tissue distribution
;
species effects
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract The acidic compounds, such as phenoxyacetic acids, substituted benzoic acids, or acetylsalicylic acid, were found to bind to bovine serum albumin (BSA). Among phenoxyacetic acids, the binding affinity to BSA was highest for 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), which was approximately 4-, 24-, and 160-fold greater than those for 2,4-dichlorophenoxyacetic acid (2,4-D), o-chlorophenoxyacetic acid (CPA), and phenoxyacetic acid (PAA), respectively. There were two binding sites in BSA for 2,4,5-T and 2,4-D, and one site for others. These acidic compounds also bound to serum albumins of other mammalian species. The binding affinity varied among species and also depended on the chemicals. However, the order of binding affinity in the albumin of each species remained the same as observed in BSA with few exceptions. Blood/tissue ratios of14C from rats dosed with these14C-labeled acids were highly correlated with the logarithm of the binding affinity constants.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01060055
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