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1

Monographie ausleihbar

Geography in Switzerland : a collection of papers offered to the 24th International Geographical Congress, Tokyo, Japan, August 1980 (1980)

Müller, Fritz [Hrsg.]

Berne [u.a.] : Commission on Geography of the Swiss Acad. of Sciences

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Signatur: PIK L 347-11-0265

Materialart: Monographie ausleihbar

Seiten: 183 S. : Ill., graph.Darst., Kt. - Buch ist unvollständig, nur bis Seite 52 vorhanden.

Serie: Geographica helvetica 35,5 : Special issue

Sprache: Unbestimmte Sprache

Standort: A 18 - Bitte bestellen

Zweigbibliothek: PIK Bibliothek

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Can monitoring data contribute to the biodiversity-ecosystem function debate? Evaluating data from a highly dynamic ecosystem (2014)

Hodapp, Dorothee ; Kraft, Dietmar ; Hillebrand, Helmut

Springer Nature

In: EPIC3Biodiversity and Conservation, Springer Nature, 23(2), pp. 405-419, ISSN: 0960-3115

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Publikationsdatum: 2023-09-22

Beschreibung: One of the most controversially discussed topics in current biodiversity-ecosystem function research is the transfer of results from experimental and theoretical studies to natural ecosystems. At the same time, monitoring data on biodiversity are requested as key indicators for the state of an ecosystem in most environmental evaluation frameworks. We analyse two monitoring data sets comprising information on abundance and biomass of macrozoobenthos communities in the German Wadden Sea in order to evaluate how much information monitoring data on biodiversity provide concerning ecosystem functioning and what implications this information (or the lack thereof) has for future monitoring programmes. Our results show a positive correlation between number of species of macrozoobenthos and its standing stock. Despite differences in overall biomass and individual size in different functional groups, this correlation remained consistent for different feeding guilds and therefore is likely to be independent of certain species traits. Moreover, functional turnover analyses indicate that increasing species richness is needed to maintain biomass levels over increasing periods of time. Whereas our data thus corroborate predictions from theory, we could not determine any causal relationships, because monitoring data commonly include only vague proxies for very few functional parameters, in our case standing biomass as a proxy for production. As to the use of diversity as an indicator for ecosystem functioning, we advise that management decisions are to be based on verified causal relationships and therefore strongly suggest the general incorporation of unambiguous proxies for functional parameters in the measuring campaigns of monitoring programmes.

Repository-Name: EPIC Alfred Wegener Institut

Materialart: Article , peerRev

Format: application/pdf

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Sifting at the ciliary base (2013)

Avasthi, Prachee

Springer Nature

In: Nature Chemical Biology. 2013; 9(7): 414-415. Published 2013 Jun 17. doi: 10.1038/nchembio.1272.

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Publikationsdatum: 2013-06-17

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Thema: Biologie , Chemie und Pharmazie

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Chemically inducible diffusion trap at cilia reveals molecular sieve–like barrier (2013)

Lin, Yu-Chun ; Niewiadomski, Pawel ; Lin, Benjamin ; [weitere]

Springer Nature

In: Nature Chemical Biology. 2013; 9(7): 437-443. Published 2013 May 12. doi: 10.1038/nchembio.1252.

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Publikationsdatum: 2013-05-12

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Mechanism-based corrector combination restores ΔF508-CFTR folding and function (2013)

Okiyoneda, Tsukasa ; Veit, Guido ; Dekkers, Johanna F ; [weitere]

Springer Nature

In: Nature Chemical Biology. 2013; 9(7): 444-454. Published 2013 May 12. doi: 10.1038/nchembio.1253.

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Publikationsdatum: 2013-05-12

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Nuclear spin effects in semiconductor quantum dots (2013)

Chekhovich, E. A. ; Makhonin, M. N. ; Tartakovskii, A. I. ; [weitere]

Springer Nature

In: Nature Materials. 2013; 12(6): 494-504. Published 2013 May 22. doi: 10.1038/nmat3652.

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Publikationsdatum: 2013-05-22

Print ISSN: 1476-1122

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Thema: Chemie und Pharmazie , Maschinenbau , Allgemeine Naturwissenschaft , Physik

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Perovskites under the Sun (2013)

Antonietta Loi, Maria ; Hummelen, Jan C.

Springer Nature

In: Nature Materials. 2013; 12(12): 1087-1089. Published 2013 Nov 21. doi: 10.1038/nmat3815.

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Publikationsdatum: 2013-11-21

Print ISSN: 1476-1122

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Thema: Chemie und Pharmazie , Maschinenbau , Allgemeine Naturwissenschaft , Physik

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Poisson's ratio at 200 (2011)

Springer Nature

In: Nature Materials. 2011; 10(11): 807-807. Published 2011 Oct 24. doi: 10.1038/nmat3167.

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Publikationsdatum: 2011-10-24

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Thema: Chemie und Pharmazie , Maschinenbau , Allgemeine Naturwissenschaft , Physik

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Graphene photonics and optoelectronics (2010)

Bonaccorso, F. ; Sun, Z. ; Hasan, T. ; [weitere]

Springer Nature

In: Nature Photonics. 2010; 4(9): 611-622. Published 2010 Aug 31. doi: 10.1038/nphoton.2010.186.

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Publikationsdatum: 2010-08-31

Print ISSN: 1749-4885

Digitale ISSN: 1749-4893

Thema: Physik

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10

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New dimensions of neuronal plasticity (1999)

Spitzer, Nicholas C.

Springer Nature

In: Nature Neuroscience. 1999; 2(6): 489-491. Published 1999 Jun 01. doi: 10.1038/9132.

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Publikationsdatum: 1999-06-01

Print ISSN: 1097-6256

Digitale ISSN: 1546-1726

Thema: Biologie , Medizin

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11

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Single spins in self-assembled quantum dots (2013)

Warburton, Richard J.

Springer Nature

In: Nature Materials. 2013; 12(6): 483-493. Published 2013 May 22. doi: 10.1038/nmat3585.

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Publikationsdatum: 2013-05-22

Print ISSN: 1476-1122

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Thema: Chemie und Pharmazie , Maschinenbau , Allgemeine Naturwissenschaft , Physik

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12

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Natural strategies for photosynthetic light harvesting (2014)

Croce, Roberta ; van Amerongen, Herbert

Springer Nature

In: Nature Chemical Biology. 2014; 10(7): 492-501. Published 2014 Jun 17. doi: 10.1038/nchembio.1555.

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Publikationsdatum: 2014-06-17

Print ISSN: 1552-4450

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Thema: Biologie , Chemie und Pharmazie

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13

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A decade of chemical biology (2010)

Bucci, Mirella ; Goodman, Catherine ; Sheppard, Terry L

Springer Nature

In: Nature Chemical Biology. 2010; 6(12): 847-854. Published 2010 Nov 15. doi: 10.1038/nchembio.489.

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Publikationsdatum: 2010-11-15

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A century of Turing (2012)

Springer Nature

In: Nature Physics. 2012; 8(12): 851-851. Published 2012 Nov 30. doi: 10.1038/nphys2512.

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Publikationsdatum: 2012-11-30

Print ISSN: 1745-2473

Digitale ISSN: 1745-2481

Thema: Physik

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15

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Plasticity in the intrinsic excitability of cortical pyramidal neurons (1999)

Desai, Niraj S. ; Rutherford, Lana C. ; Turrigiano, Gina G.

Springer Nature

In: Nature Neuroscience. 1999; 2(6): 515-520. Published 1999 Jun 01. doi: 10.1038/9165.

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Publikationsdatum: 1999-06-01

Print ISSN: 1097-6256

Digitale ISSN: 1546-1726

Thema: Biologie , Medizin

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16

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RET, ROS1 and ALK fusions in lung cancer (2012)

Takeuchi, Kengo ; Soda, Manabu ; Togashi, Yuki ; [weitere]

Springer Nature

In: Nature Medicine. 2012; 18(3): 378-381. Published 2012 Feb 12. doi: 10.1038/nm.2658.

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Publikationsdatum: 2012-02-12

Print ISSN: 1078-8956

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Thema: Biologie , Medizin

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The real war on drugs (2010)

Willyard, Cassandra

Springer Nature

In: Nature Medicine. 2010; 16(9): 948-952. Published 2010 Sep 01. doi: 10.1038/nm0910-948.

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Publikationsdatum: 2010-09-01

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18

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Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies (2012)

Lipson, Doron ; Capelletti, Marzia ; Yelensky, Roman ; [weitere]

Springer Nature

In: Nature Medicine. 2012; 18(3): 382-384. Published 2012 Feb 12. doi: 10.1038/nm.2673.

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Publikationsdatum: 2012-02-12

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Chipping away at the lung cancer genome (2012)

Pao, William ; Hutchinson, Katherine E

Springer Nature

In: Nature Medicine. 2012; 18(3): 349-351. Published 2012 Mar 01. doi: 10.1038/nm.2697.

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Publikationsdatum: 2012-03-01

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VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex (2014)

Zhang, Wenjing ; Gao, Yijun ; Li, Peixue ; [weitere]

Springer Nature

In: Cell Research. 2014; 24(3): 331-343. Published 2014 Jan 24. doi: 10.1038/cr.2014.10.

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Publikationsdatum: 2014-01-24

Print ISSN: 1001-0602

Digitale ISSN: 1748-7838

Thema: Biologie , Medizin

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21

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miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops (2012)

Song, Libing ; Lin, Chuyong ; Gong, Hui ; [weitere]

Springer Nature

In: Cell Research. 2012; 23(2): 274-289. Published 2012 Dec 18. doi: 10.1038/cr.2012.174.

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Publikationsdatum: 2012-12-18

Print ISSN: 1001-0602

Digitale ISSN: 1748-7838

Thema: Biologie , Medizin

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RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans (2014)

Hemani, Gibran ; Shakhbazov, Konstantin ; Westra, Harm-Jan ; [weitere]

Springer Nature

In: Nature. 2014; 508(7495): 249-253. Published 2014 Feb 26. doi: 10.1038/nature13005.

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Publikationsdatum: 2014-02-26

Print ISSN: 0028-0836

Digitale ISSN: 1476-4687

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

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23

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Ultrashort laser pulses squeezed out of graphene (2013)

Moskvitch, Katia

Springer Nature

In: Nature. 2013; Published 2013 May 24. doi: 10.1038/nature.2013.12911. [early online release]

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Publikationsdatum: 2013-05-24

Print ISSN: 0028-0836

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Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

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24

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Contemplating chemical biology (2010)

Springer Nature

In: Nature Chemical Biology. 2010; 6(12): 845-845. Published 2010 Nov 15. doi: 10.1038/nchembio.465x.

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Publikationsdatum: 2010-11-15

Print ISSN: 1552-4450

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Thema: Biologie , Chemie und Pharmazie

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25

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Nanoscale Joule heating, Peltier cooling and current crowding at graphene–metal contacts (2011)

Grosse, Kyle L. ; Bae, Myung-Ho ; Lian, Feifei ; [weitere]

Springer Nature

In: Nature Nanotechnology. 2011; 6(5): 287-290. Published 2011 Apr 03. doi: 10.1038/nnano.2011.39.

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Publikationsdatum: 2011-04-03

Print ISSN: 1748-3387

Digitale ISSN: 1748-3395

Thema: Biologie , Chemie und Pharmazie , Physik

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26

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KIF5B-RET fusions in lung adenocarcinoma (2012)

Kohno, Takashi ; Ichikawa, Hitoshi ; Totoki, Yasushi ; [weitere]

Springer Nature

In: Nature Medicine. 2012; 18(3): 375-377. Published 2012 Feb 12. doi: 10.1038/nm.2644.

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Publikationsdatum: 2012-02-12

Print ISSN: 1078-8956

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Thema: Biologie , Medizin

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27

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Poisson's ratio and modern materials (2011)

Greaves, G. N. ; Greer, A. L. ; Lakes, R. S. ; [weitere]

Springer Nature

In: Nature Materials. 2011; 10(11): 823-837. Published 2011 Oct 24. doi: 10.1038/nmat3134.

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Publikationsdatum: 2011-10-24

Print ISSN: 1476-1122

Digitale ISSN: 1476-4660

Thema: Chemie und Pharmazie , Maschinenbau , Allgemeine Naturwissenschaft , Physik

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Mapping identifies best targets for malaria prevention (2012)

Maxmen, Amy

Springer Nature

In: Nature. 2012; Published 2012 Jun 06. doi: 10.1038/nature.2012.10781. [early online release]

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Publikationsdatum: 2012-06-06

Print ISSN: 0028-0836

Digitale ISSN: 1476-4687

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

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Brain-simulation and graphene projects win billion-euro competition (2013)

Abbott, Alison

Springer Nature

In: Nature. 2013; Published 2013 Jan 23. doi: 10.1038/nature.2013.12291. [early online release]

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Publikationsdatum: 2013-01-23

Print ISSN: 0028-0836

Digitale ISSN: 1476-4687

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

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Towards intrinsic magnetism of graphene sheets with irregular zigzag edges (2013)

Lianlian Chen; Liwei Guo; Zhilin Li; Han Zhang; Jingjing Lin; Jiao Huang; Shifeng Jin; Xiaolong Chen

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-07

Beschreibung: The magnetism of graphene has remained divergent and controversial due to absence of reliable experimental results. Here we show the intrinsic magnetism of graphene edge states revealed based on unidirectional aligned graphene sheets derived from completely carbonized SiC crystals. It is found that ferromagnetism, antiferromagnetism and diamagnetism along with a probable superconductivity exist in the graphene with irregular zigzag edges. A phase diagram is constructed to show the evolution of the magnetism. The ferromagnetic ordering curie-temperature of the fundamental magnetic order unit (FMOU) is 820 ± 80 K. The antiferromagnetic ordering Neel temperature of the FMOUs belonging to different sublattices is about 54 ± 2 K. The diamagnetism is similar to that of graphite and can be well described by the Kotosonov's equation. Our experimental results provide new evidences to clarify the controversial experimental phenomena observed in graphene and contribute to a deeper insight into the nature of magnetism in graphene based system. Scientific Reports 3 doi: 10.1038/srep02599

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Highly sensitive and selective fluoride detection in water through fluorophore release from a metal-organic framework (2013)

Florian M. Hinterholzinger; Bastian Rühle; Stefan Wuttke; Konstantin Karaghiosoff; Thomas Bein

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-07

Beschreibung: The detection, differentiation and visualization of compounds such as gases, liquids or ions are key challenges for the design of selective optical chemosensors. Optical chemical sensors employ a transduction mechanism that converts a specific analyte recognition event into an optical signal. Here we report a novel concept for fluoride ion sensing where a porous crystalline framework serves as a host for a fluorescent reporter molecule. The detection is based on the decomposition of the host scaffold which induces the release of the fluorescent dye molecule. Specifically, the hybrid composite of the metal-organic framework NH2-MIL-101(Al) and fluorescein acting as reporter shows an exceptional turn-on fluorescence in aqueous fluoride-containing solutions. Using this novel strategy, the optical detection of fluoride is extremely sensitive and highly selective in the presence of many other anions. Scientific Reports 3 doi: 10.1038/srep02562

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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32

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Discovery of an uncovered region in fibrin clots and its clinical significance (2013)

Yohei Hisada; Masahiro Yasunaga; Shingo Hanaoka; Shinji Saijou; Takashi Sugino; Atsushi Tsuji; Tsuneo Saga; Kouhei Tsumoto; Shino Manabe; Jun-ichiro Kuroda; Jun-ichi Kuratsu; Yasuhiro Matsumura

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-07

Beschreibung: Despite the pathological importance of fibrin clot formation, little is known about the structure of these clots because X-ray and nuclear magnetic resonance (NMR) analyses are not applicable to insoluble proteins. In contrast to previously reported anti-fibrin monoclonal antibodies (mAbs), our anti-fibrin clot mAb (clone 102–10) recognises an uncovered region that is exposed only when a fibrin clot forms. The epitope of the 102–10 mAb was mapped to a hydrophobic region on the Bβ chain that interacted closely with a counterpart region on the γ chain in a soluble state. New anti-Bβ and anti-γ mAbs specific to peptides lining the discovered region appeared to bind exclusively to fibrin clots. Furthermore, the radiolabelled 102–10 mAb selectively accumulated in mouse spontaneous tumours, and immunohistochemistry using this mAb revealed greater fibrin deposition in World Health Organization (WHO) grade 4 glioma than in lower-grade gliomas. Because erosive tumours are apt to cause micro-haemorrhages, even early asymptomatic tumours detected with a radiolabelled 102-10 mAb may be aggressively malignant. Scientific Reports 3 doi: 10.1038/srep02604

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Active display and encoding by integrated plasmonic polarizer on light-emitting-diode (2013)

L. Wang; T. Li; R. Y. Guo; W. Xia; X. G. Xu; S. N. Zhu

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-07

Beschreibung: An electrical pumped microscopic active display with integration of plasmonic polarizer and light-emitting-diode is proposed. Thanks to the strong polarized emission through the rectangular nanoholes, well designed pixels with respect to different polarizations are engineered, which give rise to flexible and controllable active display. As results, polarization multiplexed letter encoding, single and double gray-scale images and animation movies are successfully realized. Our results demonstrate a new strategy in electro-optical integration and indicate potential applications in designing new type of microscopic electro-optical devices. Scientific Reports 3 doi: 10.1038/srep02603

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Standardization of surface potential measurements of graphene domains (2013)

Vishal Panchal; Ruth Pearce; Rositza Yakimova; Alexander Tzalenchuk; Olga Kazakova

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-07

Beschreibung: We compare the three most commonly used scanning probe techniques to obtain a reliable value of the work function in graphene domains of different thickness. The surface potential (SP) of graphene is directly measured in Hall bar geometry via a combination of electrical functional microscopy and spectroscopy techniques, which enables calibrated work function measurements of graphene domains in ambient conditions with values Φ1LG ~4.55 ± 0.02 eV and Φ2LG ~ 4.44 ± 0.02 eV for single- and bi-layer, respectively. We demonstrate that frequency-modulated Kelvin probe force microscopy (FM-KPFM) provides more accurate measurement of the SP than amplitude-modulated (AM)-KPFM. The discrepancy between experimental results obtained by different techniques is discussed. In addition, we use FM-KPFM for contactless measurements of the specific components of the device resistance. We show a strong non-Ohmic behavior of the electrode-graphene contact resistance and extract the graphene channel resistivity. Scientific Reports 3 doi: 10.1038/srep02597

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Involvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway (2013)

Noritaka Yamaguchi; Masaaki Oyama; Hiroko Kozuka-Hata; Jun-ichiro Inoue

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-07

Beschreibung: The non-canonical NF-κB pathway is crucial for the immune system. A critical event in activation of the non-canonical pathway is the attenuation of NF-κB-inducing kinase (NIK) degradation, which is promoted by continuous polyubiquitination of NIK catalyzed by the NIK ubiquitin-ligase complex composed of cellular inhibitor of apoptosis protein 1 and 2 (cIAP1/2), TNF receptor-associated factor 2 (TRAF2), and TRAF3. However, the molecular mechanism of stimulation-dependent NIK stabilization remains poorly understood. Here, we show that A20, a ubiquitin-editing enzyme, promotes efficient activation of the non-canonical pathway independent of its catalytic activity. A20 directly binds to cIAP1 through the seventh zinc finger of A20, resulting in dissociation of the TRAF2/TRAF3 interaction, thereby inactivating the ligase complex to stabilize NIK. Given that A20 negatively regulates the canonical pathway, A20 is likely involved in the molecular switch that promotes the transition from canonical to non-canonical activation for proper control of the immune system. Scientific Reports 3 doi: 10.1038/srep02568

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Plasmon-enhanced photocurrent generation and water oxidation from visible to near-infrared wavelengths (2013)

Kosei Ueno; Hiroaki Misawa

Springer Nature

In: NPG Asia Materials

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Publikationsdatum: 2013-09-07

Beschreibung: Plasmon-enhanced photocurrent generation and water oxidation from visible to near-infrared wavelengths NPG Asia Materials 5, e61 (September 2013). doi:10.1038/am.2013.42 Authors: Kosei Ueno & Hiroaki Misawa

Schlagwort(e): gold nanorodlocalized surface plasmon resonancenear-infrared lightphotoelectric conversionplasmonic chemistrywater oxidation

Print ISSN: 1884-4049

Digitale ISSN: 1884-4057

Thema: Maschinenbau

Publiziert von Springer Nature im Namen von The Tokyo Institute of Technology.

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Single neurons in monkey prefrontal cortex encode volitional initiation of vocalizations (2013)

Steffen R. Hage; Andreas Nieder

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-08

Beschreibung: Article The Broca area is located in the human prefrontal cortex and is involved in voluntary speech. Hage and Nieder now show that a monkey homologue of Broca’s area is similarly responsible for monkey volitional vocalizations. Nature Communications doi: 10.1038/ncomms3409 Authors: Steffen R. Hage, Andreas Nieder

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Quantal and graded stimulation of B lymphocytes as alternative strategies for regulating adaptive immune responses (2013)

E.D. Hawkins; M.L. Turner; C.J. Wellard; J.H.S. Zhou; M.R. Dowling; P.D. Hodgkin

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-08

Beschreibung: Article B lymphocytes respond to stimulation by proliferating and differentiating. Here the authors quantify and model the responses of B lymphocytes to TLR and CD40-dependent stimulation, and find that the latter induces a more complex response to signals of varying strength. Nature Communications doi: 10.1038/ncomms3406 Authors: E.D. Hawkins, M.L. Turner, C.J. Wellard, J.H.S. Zhou, M.R. Dowling, P.D. Hodgkin

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Erratum: TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells (2013)

Ralph P. Schneider; Ianire Garrobo; Miguel Foronda; Jose A. Palacios; Rosa M. Marión; Ignacio Flores; Sagrario Ortega; Maria A. Blasco

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-08

Beschreibung: Erratum Nature Communications doi: 10.1038/ncomms3309 Authors: Ralph P. Schneider, Ianire Garrobo, Miguel Foronda, Jose A. Palacios, Rosa M. Marión, Ignacio Flores, Sagrario Ortega, Maria A. Blasco

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Noble metal nanoclusters and nanoparticles precede mineral formation in magmatic sulphide melts (2013)

Hassan M. Helmy; Chris Ballhaus; Raúl O.C. Fonseca; Richard Wirth; Thorsten Nagel; Marian Tredoux

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-08

Beschreibung: Article It has long been suggested, but never shown, than nanometre-sized particles precede mineral formation in magmatic systems. Here, Helmy et al. demonstrate that platinum and arsenic self-organize to nanoparticle precursors in magmatic liquids before mineral crystallization. Nature Communications doi: 10.1038/ncomms3405 Authors: Hassan M. Helmy, Chris Ballhaus, Raúl O.C. Fonseca, Richard Wirth, Thorsten Nagel, Marian Tredoux

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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High-resolution three-dimensional mapping of mRNA export through the nuclear pore (2013)

Jiong Ma; Zhen Liu; Nicole Michelotti; Sethuramasundaram Pitchiaya; Ram Veerapaneni; John R. Androsavich; Nils G. Walter; Weidong Yang

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-08

Beschreibung: Article Messenger RNAs and their associated proteins are transported from the nucleus through highly selective nuclear pore complexes. Using ultrahigh resolution single-molecule imaging, the authors visualise the path taken by each messenger RNA as it negotiates the pore’s selectivity filter. Nature Communications doi: 10.1038/ncomms3414 Authors: Jiong Ma, Zhen Liu, Nicole Michelotti, Sethuramasundaram Pitchiaya, Ram Veerapaneni, John R. Androsavich, Nils G. Walter, Weidong Yang

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity (2013)

Yiming Zhou; Yoshiro Suzuki; Kunitoshi Uchida; Makoto Tominaga

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-08

Beschreibung: Article TRPA1 is a transient receptor potential channel family member and is involved in the detection of nociceptive stimuli. Zhou et al. identify an alternative splice variant of TRPA1, which increases TRPA1 plasma expression and channel function, and enhances pain-like behaviour in mice. Nature Communications doi: 10.1038/ncomms3399 Authors: Yiming Zhou, Yoshiro Suzuki, Kunitoshi Uchida, Makoto Tominaga

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Corrigendum: Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids (2013)

Qilong Wang; Xiaoying Zhuang; Jingyao Mu; Zhong-Bin Deng; Hong Jiang; Lifeng Zhang; Xiaoyu Xiang; Baomei Wang; Jun Yan; Donald Miller; Huang-Ge Zhang

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-08

Beschreibung: Corrigendum Nature Communications doi: 10.1038/ncomms3358 Authors: Qilong Wang, Xiaoying Zhuang, Jingyao Mu, Zhong-Bin Deng, Hong Jiang, Lifeng Zhang, Xiaoyu Xiang, Baomei Wang, Jun Yan, Donald Miller, Huang-Ge Zhang

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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In situ observation of filamentary conducting channels in an asymmetric Ta2O5−x/TaO2−x bilayer structure (2013)

Gyeong-Su Park; Young Bae Kim; Seong Yong Park; Xiang Shu Li; Sung Heo; Myoung-Jae Lee; Man Chang; Ji Hwan Kwon; M. Kim; U-In Chung; Regina Dittmann; Rainer Waser; Kinam Kim

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-08

Beschreibung: Article Despite its importance for non-volatile memory, the origin of resistive switching in a metal insulator-metal structure is unclear. Park et al. fabricate such a structure inside a transmission electron microscope to show that switching occurs via oxygen-vacancy migration, which changes the conduction channels. Nature Communications doi: 10.1038/ncomms3382 Authors: Gyeong-Su Park, Young Bae Kim, Seong Yong Park, Xiang Shu Li, Sung Heo, Myoung-Jae Lee, Man Chang, Ji Hwan Kwon, M. Kim, U-In Chung, Regina Dittmann, Rainer Waser, Kinam Kim

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Vision and air flow combine to streamline flying honeybees (2013)

Gavin J. Taylor; Tien Luu; David Ball; Mandyam V. Srinivasan

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-11

Beschreibung: Insects face the challenge of integrating multi-sensory information to control their flight. Here we study a ‘streamlining’ response in honeybees, whereby honeybees raise their abdomen to reduce drag. We find that this response, which was recently reported to be mediated by optic flow, is also strongly modulated by the presence of air flow simulating a head wind. The Johnston's organs in the antennae were found to play a role in the measurement of the air speed that is used to control the streamlining response. The response to a combination of visual motion and wind is complex and can be explained by a model that incorporates a non-linear combination of the two stimuli. The use of visual and mechanosensory cues increases the strength of the streamlining response when the stimuli are present concurrently. We propose this multisensory integration will make the response more robust to transient disturbances in either modality. Scientific Reports 3 doi: 10.1038/srep02614

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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An unprecedented (3,4,24)-connected heteropolyoxozincate organic framework as heterogeneous crystalline Lewis acid catalyst for biodiesel production (2013)

Dong-Ying Du; Jun-Sheng Qin; Zhong Sun; Li-Kai Yan; Michael O'Keeffe; Zhong-Min Su; Shun-Li Li; Xiao-Hong Wang; Xin-Long Wang; Ya-Qian Lan

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-11

Beschreibung: A novel 3D hexadecanuclear heteropolyoxozincate organic framework, IFMC-200, has been successfully synthesized based on a late transition metal-oxygen cluster. IFMC-200 not only represents the first example of (3,4,24)-connected framework but also contains the first 24-connected single metal cluster in a crystal structure. It exhibits superior thermal stability, good water-stability, and even insensitivity to the existence of acid and base within a certain range of pH values. Furthermore, it performs as a heterogeneous crystalline Lewis acid catalyst with good activity for the conversion of long-chain fatty acids rather than short-chain ones, and high recycling efficiency for esterification reaction of fatty acids with alcohols to produce biodiesel. Scientific Reports 3 doi: 10.1038/srep02616

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Integrated Prototype Nanodevices via SnO2 Nanoparticles Decorated SnSe Nanosheets (2013)

Jian-Jun Wang; Ai-Feng Lv; Yong-Qing Wang; Bo Cui; Hui-Juan Yan; Jin-Song Hu; Wen-Ping Hu; Yu-Guo Guo; Li-Jun Wan

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-11

Beschreibung: Hybrid materials made from all inorganic components are intriguing in many fields, because they have shown in-depth potential use for electronic and optoelectronic applications including solar cells, gas sensors, photodetectors, and field effect transistors. Hybrid materials made from SnO2 nanoparticles on SnSe nanosheets have been synthesized via a facile, lost-cost and safe solution method, and have been demonstrated as promising multifunctional materials in various prototype devices, including gas sensors, photodetectors, and field effect transistors. Scientific Reports 3 doi: 10.1038/srep02613

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Pharmacologically Triggered Hydrogel for Scheduling Hepatitis B Vaccine Administration (2013)

Raphael J. Gübeli; Katrin Schöneweis; Daniela Huzly; Martin Ehrbar; Ghislaine Charpin-El Hamri; Marie Daoud El-Baba; Stephan Urban; Wilfried Weber

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-11

Beschreibung: The simplification of current vaccine administration regimes is of crucial interest in order to further sustain and expand the high impact of vaccines for public health. Most vaccines including the vaccine against hepatitis B need several doses to achieve protective immunization. In order to reduce the amount of repetitive injections, depot-based approaches represent a promising strategy. We present the application of novobiocin-sensitive biohybrid hydrogels as a depot for the pharmacologically controlled release of a vaccine against hepatitis B. Upon subcutaneous implantation of the vaccine depot into mice, we were able to release the vaccine by the oral administration of the stimulus molecule novobiocin resulting in successful immunization of the mice. This material-based vaccination regime holds high promises to replace classical vaccine injections conducted by medical personnel by the simple oral uptake of the stimulus thereby solving a major obstacle in increasing hepatitis B vaccination coverage. Scientific Reports 3 doi: 10.1038/srep02610

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Glyphosate applications on arable fields considerably coincide with migrating amphibians (2013)

Gert Berger; Frieder Graef; Holger Pfeffer

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-11

Beschreibung: Glyphosate usage is increasing worldwide and the application schemes of this herbicide are currently changing. Amphibians migrating through arable fields may be harmed by Glyphosate applied to field crops. We investigated the population-based temporal coincidence of four amphibian species with Glyphosate from 2006 to 2008. Depending on a) age- and species-specific main migration periods, b) crop species, c) Glyphosate application mode for crops, and d) the presumed DT50 value (12 days or 47 days) of Glyphosate, we calculated up to 100% coincidence with Glyphosate. The amphibians regularly co-occur with pre-sowing/pre-emerging Glyphosate applications to maize in spring and with stubble management prior to crop sowing in late summer and autumn. Siccation treatment in summer coincides only with early pond-leaving juveniles. We suggest in-depth investigations of both acute and long-term effects of Glyphosate applications on amphibian populations not only focussed on exposure during aquatic periods but also terrestrial life stages. Scientific Reports 3 doi: 10.1038/srep02622

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Self-assembled clay films with a platelet–void multilayered nanostructure and flame-blocking properties (2013)

Ya-Chi Wang; Ting-Kai Huang; Shih-Huang Tung; Tzong-Ming Wu; Jiang-Jen Lin

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-11

Beschreibung: Polymeric composite films with a high loading of nano-size silicates can hardly meet the increasingly stringent fireproof and smoke-free requirements during burning. Thus, it is desirable to prepare pure clay films that can block air, heat, and flame. Here we report an organic-free clay film capable of both flame- and heat-shielding. The film was prepared from the self-assembly of nanometer-thick silicate platelets derived from the exfoliation of natural clays. The self-assembled film has a highly regular multilayered nanostructure over a large area and an appreciable volume of air entrapped in between. The combination of regular structure and substantial air volume contributes to the low thermal conductivity and flame blocking property of the film. It was demonstrated that the film can shield flame over hour duration and prevent temperature rising on the backside of film. This remarkable clay film has a myriad of uses including gas barrier, heat insulator, and fireproof devices. Scientific Reports 3 doi: 10.1038/srep02621

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Can We Build a Truly High Performance Computer Which is Flexible and Transparent? (2013)

Jhonathan P. Rojas; Galo A. Torres Sevilla; Muhammad M. Hussain

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-11

Beschreibung: State-of-the art computers need high performance transistors, which consume ultra-low power resulting in longer battery lifetime. Billions of transistors are integrated neatly using matured silicon fabrication process to maintain the performance per cost advantage. In that context, low-cost mono-crystalline bulk silicon (100) based high performance transistors are considered as the heart of today's computers. One limitation is silicon's rigidity and brittleness. Here we show a generic batch process to convert high performance silicon electronics into flexible and semi-transparent one while retaining its performance, process compatibility, integration density and cost. We demonstrate high-k/metal gate stack based p-type metal oxide semiconductor field effect transistors on 4 inch silicon fabric released from bulk silicon (100) wafers with sub-threshold swing of 80 mV dec−1 and on/off ratio of near 104 within 10% device uniformity with a minimum bending radius of 5 mm and an average transmittance of ~7% in the visible spectrum. Scientific Reports 3 doi: 10.1038/srep02609

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Epidermal growth factor receptor subunit locations determined in hydrated cells with environmental scanning electron microscopy (2013)

Diana B. Peckys; Jean-Pierre Baudoin; Magdalena Eder; Ulf Werner; Niels de Jonge

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-12

Beschreibung: Imaging single epidermal growth factor receptors (EGFR) in intact cells is presently limited by the available microscopy methods. Environmental scanning electron microscopy (ESEM) of whole cells in hydrated state in combination with specific labeling with gold nanoparticles was used to localize activated EGFRs in the plasma membranes of COS7 and A549 cells. The use of a scanning transmission electron microscopy (STEM) detector yielded a spatial resolution of 3 nm, sufficient to identify the locations of individual EGFR dimer subunits. The sizes and distribution of dimers and higher order clusters of EGFRs were determined. The distance between labels bound to dimers amounted to 19 nm, consistent with a molecular model. A fraction of the EGFRs was found in higher order clusters with sizes ranging from 32–56 nm. ESEM can be used for quantitative whole cell screening studies of membrane receptors, and for the study of nanoparticle-cell interactions in general. Scientific Reports 3 doi: 10.1038/srep02626

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Downregulation of ubiquitin level via knockdown of polyubiquitin gene Ubb as potential cancer therapeutic intervention (2013)

Choongseob Oh; Soonyong Park; Eun Kyung Lee; Yung Joon Yoo

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-12

Beschreibung: Ubiquitin is involved in almost every cellular process, and it is also known to be a stress-inducible protein. Based on previous reports that many types of cancer display an elevated level of ubiquitin, we hypothesized that this increased amount of ubiquitin is essential for the growth of cancer cells and that, consequently, the downregulation of ubiquitin may be a potential anti-cancer treatment. We first found that the level of ubiquitin can be effectively downregulated via knockdown of a polyubiquitin gene, Ubb, with siRNA (Ubb-KD) and then demonstrated its anti-cancer effects in several cancer cell lines and xenograft mice. Ubb-KD resulted in the attenuation of TNFα-induced NF-κB activation, the stabilization of the tumor suppressor p53, and stress-sensitization. Taken together, downregulation of ubiquitin through Ubb-KD is a potential anti-cancer treatment by inhibiting ubiquitination at multiple sites related to oncogenic pathways and by weakening the ability of cancer cells to overcome increased stress. Scientific Reports 3 doi: 10.1038/srep02623

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Conferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase (2013)

Yusuke Nakamichi; Aya Yoshioka; Shigeyuki Kawai; Kousaku Murata

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-12

Beschreibung: NAD kinase (NADK) is a crucial enzyme for production of NADP+. ATP-specific NADK prefers ATP to inorganic polyphosphate [poly(P)] as a phosphoryl donor, whereas poly(P)/ATP-NADK utilizes both ATP and poly(P), and is employed in industrial mass production of NADP+. Poly(P)/ATP-NADKs are distributed throughout Gram-positive bacteria and Archaea, whereas ATP-specific NADKs are found in Gram-negative α- and γ-proteobacteria and eukaryotes. In this study, we succeeded in conferring the ability to utilize poly(P) on γ-proteobacterial ATP-specific NADKs through a single amino-acid substitution; the substituted amino-acid residue is therefore important in determining the phosphoryl-donor specificity of γ-proteobacterial NADKs. We also demonstrate that a poly(P)/ATP-NADK created through this method is suitable for the poly(P)-dependent mass production of NADP+. Moreover, based on our results, we provide insight into the evolution of bacterial NADKs, in particular, how NADKs evolved from poly(P)/ATP-NADKs into ATP-specific NADKs. Scientific Reports 3 doi: 10.1038/srep02632

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Spontaneous intercalation of long-chain alkyl ammonium into edge-selectively oxidized graphite to efficiently produce high-quality graphene (2013)

Liangming Wei; Fei Wu; Diwen Shi; Changchen Hu; Xiaolin Li; Weien Yuan; Jian Wang; Jiang Zhao; Huijuan Geng; Hao Wei; Ying Wang; Nantao Hu; Yafei Zhang

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-12

Beschreibung: Mass production of high-quality graphene nanosheets (GNs) is essential for practical applications. We report that oxidation of graphite by low concentration KMnO4 at relatively high temperature (60°C) leads to edge-selectively oxidized graphite (EOG) which preserves the high crystalline graphitic structure on its basal planes while the edges are functionalized by oxygen-containing groups. Long-chain tetradecyl-ammonium salt (C14N+) could be spontaneously intercalated into EOG to form intercalated EOG-C14N+ compounds. Gentle and short-time sonication of EOG-C14N+ in toluene can full exfoliate EOG into edge-oxidized graphene nanosheets (EOGNs) with concentration of 0.67 mg/ml, monolayer population up to 90% and lateral size from 1 μm to 〉100 μm. The EOG and EOGN films show excellent electrical conductance, which is far superior to their graphene oxide (GO) counterparts. Our method provides an efficient way to produce high-quality GNs, and the resultant EOG also can be directly used for production of multifunctional materials and devices. Scientific Reports 3 doi: 10.1038/srep02636

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Abrupt rise of new machine ecology beyond human response time (2013)

Neil Johnson; Guannan Zhao; Eric Hunsader; Hong Qi; Nicholas Johnson; Jing Meng; Brian Tivnan

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-12

Beschreibung: Society's techno-social systems are becoming ever faster and more computer-orientated. However, far from simply generating faster versions of existing behaviour, we show that this speed-up can generate a new behavioural regime as humans lose the ability to intervene in real time. Analyzing millisecond-scale data for the world's largest and most powerful techno-social system, the global financial market, we uncover an abrupt transition to a new all-machine phase characterized by large numbers of subsecond extreme events. The proliferation of these subsecond events shows an intriguing correlation with the onset of the system-wide financial collapse in 2008. Our findings are consistent with an emerging ecology of competitive machines featuring ‘crowds’ of predatory algorithms, and highlight the need for a new scientific theory of subsecond financial phenomena. Scientific Reports 3 doi: 10.1038/srep02627

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737 (2013)

A Maamer-Azzabi; O Ndozangue-Touriguine; J Bréard

Springer Nature

In: Cell Death & Disease

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Publikationsdatum: 2013-09-13

Beschreibung: Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737 Cell Death and Disease 4, e801 (September 2013). doi:10.1038/cddis.2013.328 Authors: A Maamer-Azzabi, O Ndozangue-Touriguine & J Bréard

Schlagwort(e): anoikiscolon cancerBcl-2 familymetastasisABT-737

Digitale ISSN: 2041-4889

Thema: Biologie , Medizin

Publiziert von Springer Nature

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Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis (2013)

L Steinhart; K Belz; S Fulda

Springer Nature

In: Cell Death & Disease

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Publikationsdatum: 2013-09-13

Beschreibung: Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis Cell Death and Disease 4, e802 (September 2013). doi:10.1038/cddis.2013.320 Authors: L Steinhart, K Belz & S Fulda

Schlagwort(e): apoptosisnecroptosisSmacleukemiaRIP1

Digitale ISSN: 2041-4889

Thema: Biologie , Medizin

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Engineering of cofactor regeneration enhances (2S,3S)-2,3-butanediol production from diacetyl (2013)

Yu Wang; Lixiang Li; Cuiqing Ma; Chao Gao; Fei Tao; Ping Xu

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-13

Beschreibung: (2S,3S)-2,3-Butanediol ((2S,3S)-2,3-BD) is a potentially valuable liquid fuel and an excellent building block in asymmetric synthesis. In this study, cofactor engineering was applied to improve the efficiency of (2S,3S)-2,3-BD production and simplify the product purification. Two NADH regeneration enzymes, glucose dehydrogenase and formate dehydrogenase (FDH), were introduced into Escherichia coli with 2,3-BD dehydrogenase, respectively. Introduction of FDH resulted in higher (2S,3S)-2,3-BD concentration, productivity and yield from diacetyl, and large increase in the intracellular NADH concentration. In fed-batch bioconversion, the final titer, productivity and yield of (2S,3S)-2,3-BD on diacetyl reached 31.7 g/L, 2.3 g/(L·h) and 89.8%, the highest level of (2S,3S)-2,3-BD production thus far. Moreover, cosubstrate formate was almost totally converted to carbon dioxide and no organic acids were produced. The biocatalytic process presented should be a promising route for biotechnological production of NADH-dependent microbial metabolites. Scientific Reports 3 doi: 10.1038/srep02643

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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In vivo Optical Coherence Tomography of Light-Driven Melanosome Translocation in Retinal Pigment Epithelium (2013)

Qiu-Xiang Zhang; Rong-Wen Lu; Jeffrey D. Messinger; Christine A. Curcio; Vincenzo Guarcello; Xin-Cheng Yao

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-13

Beschreibung: Optical coherence tomography (OCT) may revolutionize fundamental investigation and clinical management of age-related macular degeneration and other eye diseases. However, quantitative OCT interpretation is hampered due to uncertain sub-cellular correlates of reflectivity in the retinal pigment epithelium (RPE) and photoreceptor. The purpose of this study was twofold: 1) to test OCT correlates in the RPE, and 2) to demonstrate the feasibility of longitudinal OCT monitoring of sub-cellular RPE dynamics. A high resolution OCT was constructed to achieve dynamic imaging of frog eyes, in which light-driven translocation of RPE melanosomes occurred within the RPE cell body and apical processes. Comparative histological examination of dark- and light-adapted eyes indicated that the RPE melanin granule, i.e., melanosome, was a primary OCT correlate. In vivo OCT imaging of RPE melanosomes opens the opportunity for quantitative assessment of RPE abnormalities associated with disease, and enables longitudinal investigation of RPE kinetics correlated with visual function. Scientific Reports 3 doi: 10.1038/srep02644

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Feeling the force: Returning haptic signals influence effort inference during motor coordination (2013)

G. Ganesh; R. Osu; E. Naito

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-13

Beschreibung: Our brain is known to automatically optimize effort expenditure during motor coordination, such that for example, during bimanual braking of a bicycle, a well-oiled brake will automatically be used more than a corroded, heavy brake. But how does our brain infer the effort expenditure? All previous motor coordination models have believed that the effort in a task is known precisely to our brain, solely from the motor commands it generates. Here we show that this belief is incorrect. Through experiments and simulation we exhibit that in addition to the motor commands, the returning haptic signals play a crucial role in the inference of the effort during a force sharing task. Our results thus elucidate a previously unknown sensory-motor association that has major ramifications for our understanding of motor coordination and provides new insights into how sensory modifications due to ergonomics, stroke and disease can affect motor coordination in humans. Scientific Reports 3 doi: 10.1038/srep02648

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Directing reaction pathways by catalyst active-site selection using self-assembled monolayers (2013)

Simon H. Pang; Carolyn A. Schoenbaum; Daniel K. Schwartz; J. Will Medlin

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-14

Beschreibung: Article Control of active sites of heterogeneous catalysts can lead to enhanced product selectivity. Here, the authors use self-assembled alkanethiolate monolayers with varying surface densities to tune the selectivity of hydrogenation and hydrodeoxygenation of furfural on supported palladium catalysts. Nature Communications doi: 10.1038/ncomms3448 Authors: Simon H. Pang, Carolyn A. Schoenbaum, Daniel K. Schwartz, J. Will Medlin

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Free-decay and resonant methods for investigating the fundamental limit of superhydrophobicity (2013)

Jaakko V.I. Timonen; Mika Latikka; Olli Ikkala; Robin H.A. Ras

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-14

Beschreibung: Article Knowing how moving droplets dissipate energy is important for designing superhydrophobic surfaces, but measuring such small energy losses is challenging. Timonen et al. develop a technique to do this, which monitors freely decaying and resonant oscillations of moving magnetic droplets. Nature Communications doi: 10.1038/ncomms3398 Authors: Jaakko V.I. Timonen, Mika Latikka, Olli Ikkala, Robin H.A. Ras

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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A nanopore machine promotes the vectorial transport of DNA across membranes (2013)

Lorenzo Franceschini; Misha Soskine; Annemie Biesemans; Giovanni Maglia

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-14

Beschreibung: Article Transport of DNA molecules across lipid membranes requires protein conduits such as the nuclear pore complex. Franceschini et al. engineer an artificial sequence-selective DNA transporter by attaching gating oligonucleotides to a bacterial nanopore. Nature Communications doi: 10.1038/ncomms3415 Authors: Lorenzo Franceschini, Misha Soskine, Annemie Biesemans, Giovanni Maglia

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Diameter-dependent ion transport through the interior of isolated single-walled carbon nanotubes (2013)

Wonjoon Choi; Zachary W. Ulissi; Steven F.E. Shimizu; Darin O. Bellisario; Mark D. Ellison; Michael S. Strano

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-14

Beschreibung: Article Calculations suggest that ion transport through nanochannels is significantly modified as the diameter approaches molecular dimensions. Choi et al. introduce a single-nanotube platform to demonstrate this effect and find a maximum ion transport rate at a diameter of approximately 1.6 nm. Nature Communications doi: 10.1038/ncomms3397 Authors: Wonjoon Choi, Zachary W. Ulissi, Steven F.E. Shimizu, Darin O. Bellisario, Mark D. Ellison, Michael S. Strano

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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An entanglement-enhanced microscope (2013)

Takafumi Ono; Ryo Okamoto; Shigeki Takeuchi

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-14

Beschreibung: Article In microscopy, the standard quantum limit represents the best achievable signal-to-noise ratio for a given light intensity. Here, the authors build an optical microscope that uses entanglement between photon pairs to overcome this barrier. Nature Communications doi: 10.1038/ncomms3426 Authors: Takafumi Ono, Ryo Okamoto, Shigeki Takeuchi

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Carbon precipitation from heavy hydrocarbon fluid in deep planetary interiors (2013)

Sergey S. Lobanov; Pei-Nan Chen; Xiao-Jia Chen; Chang-Sheng Zha; Konstantin D. Litasov; Ho-Kwang Mao; Alexander F. Goncharov

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-14

Beschreibung: Article Methane is a major constituent of planetary interiors, yet phase relations in the C–H system are poorly understood. This work documents the chemical reactivity of the C–H system over a wide range of temperatures and pressures, and sheds light on the chemical composition of Earth and icy giants. Nature Communications doi: 10.1038/ncomms3446 Authors: Sergey S. Lobanov, Pei-Nan Chen, Xiao-Jia Chen, Chang-Sheng Zha, Konstantin D. Litasov, Ho-Kwang Mao, Alexander F. Goncharov

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Transparent functional oxide stretchable electronics: micro-tectonics enabled high strain electrodes (2013)

Philipp Gutruf; Charan M Shah; Sumeet Walia; Hussein Nili; Ahmad S Zoolfakar; Christian Karnutsch; Kourosh Kalantar-zadeh; Sharath Sriram; Madhu Bhaskaran

Springer Nature

In: NPG Asia Materials

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Publikationsdatum: 2013-09-14

Beschreibung: Transparent functional oxide stretchable electronics: micro-tectonics enabled high strain electrodes NPG Asia Materials 5, e62 (September 2013). doi:10.1038/am.2013.41 Authors: Philipp Gutruf, Charan M Shah, Sumeet Walia, Hussein Nili, Ahmad S Zoolfakar, Christian Karnutsch, Kourosh Kalantar-zadeh, Sharath Sriram & Madhu Bhaskaran

Schlagwort(e): flexible electronicsfunctional oxideshigh-temperature oxidesITOPDMStransparent materialsZnO

Print ISSN: 1884-4049

Digitale ISSN: 1884-4057

Thema: Maschinenbau

Publiziert von Springer Nature im Namen von The Tokyo Institute of Technology.

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Probing the Interplay between Quantum Charge Fluctuations and Magnetic Ordering in LuFe2O4 (2013)

J. Lee; S. A. Trugman; C. D. Batista; C. L. Zhang; D. Talbayev; X. S. Xu; S.-W. Cheong; D. A. Yarotski; A. J. Taylor; R. P. Prasankumar

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-14

Beschreibung: The mechanisms producing strong coupling between electric and magnetic order in multiferroics are not always well understood, since their microscopic origins can be quite different. Hence, gaining a deeper understanding of magnetoelectric coupling in these materials is the key to their rational design. Here, we use ultrafast optical spectroscopy to show that the influence of magnetic ordering on quantum charge fluctuations via the double-exchange mechanism can govern the interplay between electric polarization and magnetism in the charge-ordered multiferroic LuFe2O4. Scientific Reports 3 doi: 10.1038/srep02654

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Time-calibrated Milankovitch cycles for the late Permian (2013)

Huaichun Wu; Shihong Zhang; Linda A. Hinnov; Ganqing Jiang; Qinglai Feng; Haiyan Li; Tianshui Yang

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-15

Beschreibung: Article The astronomical time scale is an essential geochronological tool, but is presently limited to the Cenozoic and Mesozoic eras. Here, Wu et al. time-calibrate Milankovitch cycles identified in strata from South China and extend this essential tool into the late Permian. Nature Communications doi: 10.1038/ncomms3452 Authors: Huaichun Wu, Shihong Zhang, Linda A. Hinnov, Ganqing Jiang, Qinglai Feng, Haiyan Li, Tianshui Yang

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Social amoeba farmers carry defensive symbionts to protect and privatize their crops (2013)

Debra A. Brock; Silven Read; Alona Bozhchenko; David C. Queller; Joan E. Strassmann

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-15

Beschreibung: Article The social amoeba Dictyostelium discoideum displays a primitive form of agriculture with some clones carrying bacteria to seed out food crops. Brock et al . now demonstrate that these farmers also carry non-food bacteria that harm competing non-farmer amoeba clones, protecting the crop from exploitation. Nature Communications doi: 10.1038/ncomms3385 Authors: Debra A. Brock, Silven Read, Alona Bozhchenko, David C. Queller, Joan E. Strassmann

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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An experimental test on the probability of extinction of new genetic variants (2013)

Ivo M. Chelo; Judit Nédli; Isabel Gordo; Henrique Teotónio

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-15

Beschreibung: Article A central tenet of population genetics is that the probability of fixing beneficial new alleles in a population is twice their fitness effect, but this has not been empirically proven. Chelo et al . show experimentally, using nematode worms, that extinction rates decrease when the number of beneficial alleles increases. Nature Communications doi: 10.1038/ncomms3417 Authors: Ivo M. Chelo, Judit Nédli, Isabel Gordo, Henrique Teotónio

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Oblique subduction modelling indicates along-trench tectonic transport of sediments (2013)

Cristina Malatesta; Taras Gerya; Laura Crispini; Laura Federico; Giovanni Capponi

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-15

Beschreibung: Article Sedimentation along convergent plate margins, the destructive sites of tectonic plate collision, is poorly understood. Malatesta et al. use a cutting-edge three-dimensinal subduction model to demonstrate that the trench-parallel motion of sediments has a much more important role than previously thought. Nature Communications doi: 10.1038/ncomms3456 Authors: Cristina Malatesta, Taras Gerya, Laura Crispini, Laura Federico, Giovanni Capponi

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Badgers to blame for bovine TB? (2013)

Ursula Hofer

Springer Nature

In: Nature Reviews Microbiology

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Publikationsdatum: 2013-09-17

Beschreibung: Nature Reviews Microbiology 11, 660 (2013). doi:10.1038/nrmicro3130 Author: Ursula Hofer Mycobacterium bovis causes tuberculosis (TB) in cattle, but it can also infect wild animals and, occasionally, humans. In the United Kingdom, badgers are thought to spread M. bovis between farms, thereby hindering disease eradication. Two controversial programmes are now underway to tackle the

Print ISSN: 1740-1526

Digitale ISSN: 1740-1534

Thema: Biologie , Medizin

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A microbial decade (2013)

Springer Nature

In: Nature Reviews Microbiology

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Publikationsdatum: 2013-09-17

Beschreibung: Nature Reviews Microbiology 11, 657 (2013). doi:10.1038/nrmicro3128 In celebration of our tenth anniversary, we revisit selected topics from the first few issues of the journal and assess the progress that has been made over the past decade.

Print ISSN: 1740-1526

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Thema: Biologie , Medizin

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Propelling vaccinia virus to the neighbours (2013)

Rachel David

Springer Nature

In: Nature Reviews Microbiology

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Publikationsdatum: 2013-09-17

Beschreibung: Nature Reviews Microbiology 11, 661 (2013). doi:10.1038/nrmicro3116 Author: Rachel David Nature Reviews Microbiology11, 595 (2013)In the original article, the first author's name (Handa, Y.) was incorrect in the cited reference; this has now been corrected online. We apologize for any confusion caused.

Print ISSN: 1740-1526

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Thema: Biologie , Medizin

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Techniques and applications: Minimizing the risk (2013)

Rachel David

Springer Nature

In: Nature Reviews Microbiology

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Publikationsdatum: 2013-09-17

Beschreibung: Nature Reviews Microbiology 11, 661 (2013). doi:10.1038/nrmicro3121 Author: Rachel David Recent work on H5N1 influenza A virus, in which strains have been genetically engineered to enable aerosol transmission between ferrets, has been criticized for potentially being dangerous. Here, Langlois et al. present an approach that could be used to improve the biosafety of such

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Thema: Biologie , Medizin

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Fungal pathogenesis: SPRR spurs fungal growth (2013)

Rachel David

Springer Nature

In: Nature Reviews Microbiology

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Publikationsdatum: 2013-09-17

Beschreibung: Nature Reviews Microbiology 11, 661 (2013). doi:10.1038/nrmicro3122 Author: Rachel David The highly conserved phosphatase calcineurin is required for hyphal growth and virulence in the filamentous fungus Aspergillus fumigatus. This study identifies a region (located in the linker between the catalytic domain (CnaA) and the regulatory domain (CnaB)) that has a key role in hyphal

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Thema: Biologie , Medizin

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Bacterial physiology: A raincoat for Bacillus subtilis (2013)

Ursula Hofer

Springer Nature

In: Nature Reviews Microbiology

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Publikationsdatum: 2013-09-17

Beschreibung: Nature Reviews Microbiology 11, 660 (2013). doi:10.1038/nrmicro3115 Author: Ursula Hofer The Bacillus subtilis protein BslA self-assembles into a water-repellent film that coats the surface of biofilms.

Print ISSN: 1740-1526

Digitale ISSN: 1740-1534

Thema: Biologie , Medizin

Publiziert von Springer Nature

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Bacterial physiology: Coping with stress the C. crescentus way (2013)

Rachel David

Springer Nature

In: Nature Reviews Microbiology

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Publikationsdatum: 2013-09-17

Beschreibung: Nature Reviews Microbiology 11, 660 (2013). doi:10.1038/nrmicro3113 Author: Rachel David In Caulobacter crescentus, DNA replication is paused during proteotoxic stress through Lon-mediated degradation of DnaA.

Print ISSN: 1740-1526

Digitale ISSN: 1740-1534

Thema: Biologie , Medizin

Publiziert von Springer Nature

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Human gut microbiota community structures in urban and rural populations in Russia (2013)

Alexander V. Tyakht; Elena S. Kostryukova; Anna S. Popenko; Maxim S. Belenikin; Alexander V. Pavlenko; Andrey K. Larin; Irina Y. Karpova; Oksana V. Selezneva; Tatyana A. Semashko; Elena A. Ospanova; Vladislav V. Babenko; Igor V. Maev; Sergey V. Cheremushkin; Yuriy A. Kucheryavyy; Petr L. Shcherbakov; Vladimir B. Grinevich; Oleg I. Efimov; Evgenii I. Sas; Rustam A. Abdulkhakov; Sayar R. Abdulkhakov; Elena A. Lyalyukova; Maria A. Livzan; Valentin V. Vlassov; Renad Z. Sagdeev; Vladislav V. Tsukanov; Marina F. Osipenko; Irina V. Kozlova; Alexander V. Tkachev; Valery I. Sergienko; Dmitry G. Alexeev; Vadim M. Govorun

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-18

Beschreibung: Article The structure of the human gut microbiota has been shown to vary between populations. Tyakht et al. analyse the gut microbiota assembly from Russian individuals living in urban and rural areas, and compare these with previously studied populations. Nature Communications doi: 10.1038/ncomms3469 Authors: Alexander V. Tyakht, Elena S. Kostryukova, Anna S. Popenko, Maxim S. Belenikin, Alexander V. Pavlenko, Andrey K. Larin, Irina Y. Karpova, Oksana V. Selezneva, Tatyana A. Semashko, Elena A. Ospanova, Vladislav V. Babenko, Igor V. Maev, Sergey V. Cheremushkin, Yuriy A. Kucheryavyy, Petr L. Shcherbakov, Vladimir B. Grinevich, Oleg I. Efimov, Evgenii I. Sas, Rustam A. Abdulkhakov, Sayar R. Abdulkhakov, Elena A. Lyalyukova, Maria A. Livzan, Valentin V. Vlassov, Renad Z. Sagdeev, Vladislav V. Tsukanov, Marina F. Osipenko, Irina V. Kozlova, Alexander V. Tkachev, Valery I. Sergienko, Dmitry G. Alexeev, Vadim M. Govorun

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Protein synthesis rate is the predominant regulator of protein expression during differentiation (2013)

Anders R Kristensen; Joerg Gsponer; Leonard J Foster

Springer Nature

In: Molecular Systems Biology

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Publikationsdatum: 2013-09-18

Beschreibung: Molecular Systems Biology 9, (2013). doi:10.1038/msb.2013.47 Authors: Anders R Kristensen, Joerg Gsponer & Leonard J Foster

Digitale ISSN: 1744-4292

Thema: Biologie

Publiziert von Springer Nature im Namen von The European Molecular Biology Organization (EMBO).

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Hydrogenosomes in the diplomonad Spironucleus salmonicida (2013)

Jon Jerlström-Hultqvist; Elin Einarsson; Feifei Xu; Karin Hjort; Bo Ek; Daniel Steinhauf; Kjell Hultenby; Jonas Bergquist; Jan O. Andersson; Staffan G. Svärd

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-19

Beschreibung: Article Hydrogenosomes and mitosomes are mitochondria-related organelles with distinct properties. Here the authors find that the mitochondria-related organelle of the salmon parasite Spironucleus salmonicida has characteristics of both diplomonad mitosomes and of parabasalid hydrogenosomes, suggesting the presence of hydrogenosomes in the last common ancestor. Nature Communications doi: 10.1038/ncomms3493 Authors: Jon Jerlström-Hultqvist, Elin Einarsson, Feifei Xu, Karin Hjort, Bo Ek, Daniel Steinhauf, Kjell Hultenby, Jonas Bergquist, Jan O. Andersson, Staffan G. Svärd

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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The tiger genome and comparative analysis with lion and snow leopard genomes (2013)

Yun Sung Cho; Li Hu; Haolong Hou; Hang Lee; Jiaohui Xu; Soowhan Kwon; Sukhun Oh; Hak-Min Kim; Sungwoong Jho; Sangsoo Kim; Young-Ah Shin; Byung Chul Kim; Hyunmin Kim; Chang-uk Kim; Shu-Jin Luo; Warren E. Johnson; Klaus-Peter Koepfli; Anne Schmidt-Küntzel; Jason A. Turner; Laurie Marker; Cindy Harper; Susan M. Miller; Wilhelm Jacobs; Laura D. Bertola; Tae Hyung Kim; Sunghoon Lee; Qian Zhou; Hyun-Ju Jung; Xiao Xu; Priyvrat Gadhvi; Pengwei Xu; Yingqi Xiong; Yadan Luo; Shengkai Pan; Caiyun Gou; Xiuhui Chu; Jilin Zhang; Sanyang Liu; Jing He; Ying Chen; Linfeng Yang; Yulan Yang; Jiaju He; Sha Liu; Junyi Wang; Chul Hong Kim; Hwanjong Kwak; Jong-Soo Kim; Seungwoo Hwang; Junsu Ko; Chang-Bae Kim; Sangtae Kim; Damdin Bayarlkhagva; Woon Kee Paek; Seong-Jin Kim; Stephen J. O’Brien; Jun Wang; Jong Bhak

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-19

Beschreibung: Article Tigers are an endangered species and therefore understanding their genetic architecture could aid conservation efforts. Here, the authors report the first genome sequence of the Amur tiger and, through close species comparative genomic analysis, provide insight into the genome organization, evolutionary divergence and diversity of big cats. Nature Communications doi: 10.1038/ncomms3433 Authors: Yun Sung Cho, Li Hu, Haolong Hou, Hang Lee, Jiaohui Xu, Soowhan Kwon, Sukhun Oh, Hak-Min Kim, Sungwoong Jho, Sangsoo Kim, Young-Ah Shin, Byung Chul Kim, Hyunmin Kim, Chang-uk Kim, Shu-Jin Luo, Warren E. Johnson, Klaus-Peter Koepfli, Anne Schmidt-Küntzel, Jason A. Turner, Laurie Marker, Cindy Harper, Susan M. Miller, Wilhelm Jacobs, Laura D. Bertola, Tae Hyung Kim, Sunghoon Lee, Qian Zhou, Hyun-Ju Jung, Xiao Xu, Priyvrat Gadhvi, Pengwei Xu, Yingqi Xiong, Yadan Luo, Shengkai Pan, Caiyun Gou, Xiuhui Chu, Jilin Zhang, Sanyang Liu, Jing He, Ying Chen, Linfeng Yang, Yulan Yang, Jiaju He, Sha Liu, Junyi Wang, Chul Hong Kim, Hwanjong Kwak, Jong-Soo Kim, Seungwoo Hwang, Junsu Ko, Chang-Bae Kim, Sangtae Kim, Damdin Bayarlkhagva, Woon Kee Paek, Seong-Jin Kim, Stephen J. O’Brien, Jun Wang, Jong Bhak

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Cadmium iodide-mediated allenylation of terminal alkynes with ketones (2013)

Xinjun Tang; Can Zhu; Tao Cao; Jingqiang Kuang; Weilong Lin; Shengjun Ni; Jiasheng Zhang; Shengming Ma

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-19

Beschreibung: Article The allenylation of terminal alkynes is a convenient route to allenes from simple starting materials, though previously limited to formaldehyde and aldehyde substrates. Here a method enabling the use of ketones is reported, giving easy access to trisubstituted allenes. Nature Communications doi: 10.1038/ncomms3450 Authors: Xinjun Tang, Can Zhu, Tao Cao, Jingqiang Kuang, Weilong Lin, Shengjun Ni, Jiasheng Zhang, Shengming Ma

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Master regulators of FGFR2 signalling and breast cancer risk (2013)

Michael N. C. Fletcher; Mauro A. A. Castro; Xin Wang; Ines de Santiago; Martin O’Reilly; Suet-Feung Chin; Oscar M. Rueda; Carlos Caldas; Bruce A. J. Ponder; Florian Markowetz; Kerstin B. Meyer

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-19

Beschreibung: Article FGFR2 gene variation is associated with breast cancer risk but the molecular mechanism is unknown. Fletcher et al . provide a link between FGFR2 signalling and breast cancer susceptibility by demonstrating that FGFR2 signalling activates the ERa transcriptional network, which drives transcription of risk genes. Nature Communications doi: 10.1038/ncomms3464 Authors: Michael N. C. Fletcher, Mauro A. A. Castro, Xin Wang, Ines de Santiago, Martin O’Reilly, Suet-Feung Chin, Oscar M. Rueda, Carlos Caldas, Bruce A. J. Ponder, Florian Markowetz, Kerstin B. Meyer

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Double perovskites as a family of highly active catalysts for oxygen evolution in alkaline solution (2013)

Alexis Grimaud; Kevin J. May; Christopher E. Carlton; Yueh-Lin Lee; Marcel Risch; Wesley T. Hong; Jigang Zhou; Yang Shao-Horn

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-19

Beschreibung: Article New catalysts for the oxygen evolution reaction in basic solution are important for energy storage applications. Here, the authors report the high activity and stability of double perovskites in this role, and their performance is attributed to the proximity of the oxygen p -band to the Fermi level. Nature Communications doi: 10.1038/ncomms3439 Authors: Alexis Grimaud, Kevin J. May, Christopher E. Carlton, Yueh-Lin Lee, Marcel Risch, Wesley T. Hong, Jigang Zhou, Yang Shao-Horn

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Subicular activation preceding hippocampal ripples in vitro (2013)

Hiroaki Norimoto; Nobuyoshi Matsumoto; Takeyuki Miyawaki; Norio Matsuki; Yuji Ikegaya

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-19

Beschreibung: Sharp wave-ripple complexes (SW-Rs), a transient form of high-frequency field oscillations observed in the hippocampus, are thought to mediate memory consolidation. They are initiated mainly in hippocampal CA3 area and propagate to the entorhinal cortex through the subiculum; however, little is known about how SW-Rs are initiated and propagate. Here, we used functional multineuronal calcium imaging to monitor SW-R-relevant neuronal activity from the subiculum at single-cell resolution. An unexpected finding was that a subset of subicular neurons was activated immediately before hippocampal SW-Rs. The SW-R-preceding activity was not abolished by surgical lesion of the CA1-to-subiculum projection, and thus, it probably arose from entorhinal inputs. Therefore, SW-Rs are likely to be triggered by entorhinal-to-CA3/CA1 inputs. Moreover, the subiculum is not merely a passive intermediate region that SW-Rs pass through, but rather, it seems to contribute to an active modification of neural information related to SW-Rs. Scientific Reports 3 doi: 10.1038/srep02696

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Heavy fermion properties of the Kondo Lattice model (2013)

Steffen Sykora; Klaus W. Becker

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-19

Beschreibung: We study the S = 1/2 Kondo lattice model which is widely used to describe heavy fermion behavior. In conventional treatments of the model the Kondo interaction is decoupled in favour of a hybridization of conduction and localized f electrons. However, such an approximation breaks the local gauge symmetry and implicates that the local f-occupation is no longer conserved. To avoid these problems, we use in this work an alternative approach to the model based on the Projective Renormalization Method (PRM). Thereby, within the conduction electron spectral function we identify the lattice Kondo resonance as an almost flat excitation near the Fermi surface which is composed of conduction electron creation operators combined with localized spin fluctuations. This leads to an alternative description of the Kondo resonance without having to resort to an artificial symmetry breaking. Scientific Reports 3 doi: 10.1038/srep02691

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Diversity of individual mobility patterns and emergence of aggregated scaling laws (2013)

Xiao-Yong Yan; Xiao-Pu Han; Bing-Hong Wang; Tao Zhou

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-19

Beschreibung: Uncovering human mobility patterns is of fundamental importance to the understanding of epidemic spreading, urban transportation and other socioeconomic dynamics embodying spatiality and human travel. According to the direct travel diaries of volunteers, we show the absence of scaling properties in the displacement distribution at the individual level,while the aggregated displacement distribution follows a power law with an exponential cutoff. Given the constraint on total travelling cost, this aggregated scaling law can be analytically predicted by the mixture nature of human travel under the principle of maximum entropy. A direct corollary of such theory is that the displacement distribution of a single mode of transportation should follow an exponential law, which also gets supportive evidences in known data. We thus conclude that the travelling cost shapes the displacement distribution at the aggregated level. Scientific Reports 3 doi: 10.1038/srep02678

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

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Good Agreements Make Good Friends (2013)

The Anh Han; Luís Moniz Pereira; Francisco C. Santos; Tom Lenaerts

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-19

Beschreibung: When starting a new collaborative endeavor, it pays to establish upfront how strongly your partner commits to the common goal and what compensation can be expected in case the collaboration is violated. Diverse examples in biological and social contexts have demonstrated the pervasiveness of making prior agreements on posterior compensations, suggesting that this behavior could have been shaped by natural selection. Here, we analyze the evolutionary relevance of such a commitment strategy and relate it to the costly punishment strategy, where no prior agreements are made. We show that when the cost of arranging a commitment deal lies within certain limits, substantial levels of cooperation can be achieved. Moreover, these levels are higher than that achieved by simple costly punishment, especially when one insists on sharing the arrangement cost. Not only do we show that good agreements make good friends, agreements based on shared costs result in even better outcomes. Scientific Reports 3 doi: 10.1038/srep02695

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Nephrons require Rho-kinase for proximal-distal polarity development (2013)

Nils O. Lindström; Peter Hohenstein; Jamie A. Davies

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2013-09-19

Beschreibung: Epithelial tubules must have the right length and pattern for proper function. In the nephron, planar cell polarity controls elongation along the proximal-distal axis. As the tubule lengthens, specialized segments (proximal, distal etc.) begin to differentiate along it. Other epithelia need Rho-kinase for planar cell polarity but it is not known whether Rho-kinase is involved in this way in the nephron. We show that Rho-kinase is essential for the morphogenesis of nephrons, specifically for correct cell orientation and volume. We use fluorescent reporter-models and progenitor-specific markers to demonstrate that inhibition of Rho-kinase prevents proper proximal-distal axis formation, causes segments to develop abnormally, and progenitor-cell segregation to fail. Our data demonstrate the importance of Rho-kinase in normal nephron tubulogenesis and patterning. Scientific Reports 3 doi: 10.1038/srep02692

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia (2013)

T Prezma; A Shteinfer; L Admoni; Z Raviv; I Sela; I Levi; V Shoshan-Barmatz

Springer Nature

In: Cell Death & Disease

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Publikationsdatum: 2013-09-20

Beschreibung: VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia Cell Death and Disease 4, e809 (September 2013). doi:10.1038/cddis.2013.316 Authors: T Prezma, A Shteinfer, L Admoni, Z Raviv, I Sela, I Levi & V Shoshan-Barmatz

Schlagwort(e): apoptosisCLLmetabolismmitochondriapeptidesVDAC1

Digitale ISSN: 2041-4889

Thema: Biologie , Medizin

Publiziert von Springer Nature

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Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration (2013)

M Leibinger; A Andreadaki; H Diekmann; D Fischer

Springer Nature

In: Cell Death & Disease

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Publikationsdatum: 2013-09-20

Beschreibung: Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration Cell Death and Disease 4, e805 (September 2013). doi:10.1038/cddis.2013.310 Authors: M Leibinger, A Andreadaki, H Diekmann & D Fischer

Schlagwort(e): STAT3CNTFinflammatory stimulationoptic nerve regenerationneuroprotection

Digitale ISSN: 2041-4889

Thema: Biologie , Medizin

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The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells (2013)

M-C Chen; C-H Chen; J-C Wang; A-C Tsai; J-P Liou; S-L Pan; C-M Teng

Springer Nature

In: Cell Death & Disease

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Publikationsdatum: 2013-09-20

Beschreibung: The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells Cell Death and Disease 4, e810 (September 2013). doi:10.1038/cddis.2013.330 Authors: M-C Chen, C-H Chen, J-C Wang, A-C Tsai, J-P Liou, S-L Pan & C-M Teng

Schlagwort(e): lung cancerHDACsynergisticEGFRapoptosiserlotinib

Digitale ISSN: 2041-4889

Thema: Biologie , Medizin

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Erratum: Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65 (2013)

Yi Xiang; Xiaoyan Zhang; David B Nix; Toshihiko Katoh; Kazuhiro Aoki; Michael Tiemeyer; Yanzhuang Wang

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-20

Beschreibung: Erratum Nature Communications doi: 10.1038/ncomms3310 Authors: Yi Xiang, Xiaoyan Zhang, David B Nix, Toshihiko Katoh, Kazuhiro Aoki, Michael Tiemeyer, Yanzhuang Wang

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction (2013)

Agustin Anastasia; Katrin Deinhardt; Moses V. Chao; Nathan E. Will; Krithi Irmady; Francis S. Lee; Barbara L. Hempstead; Clay Bracken

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-20

Beschreibung: Article The Val66Met single-nucleotide polymorphism in the BDNF gene is implicated in neuropsychiatric disorders. Anastasia et al. show that this polymorphism results in structural changes in the brain-derived neurotrophic factor prodomain, and growth cone retraction in the hippocampal neurons. Nature Communications doi: 10.1038/ncomms3490 Authors: Agustin Anastasia, Katrin Deinhardt, Moses V. Chao, Nathan E. Will, Krithi Irmady, Francis S. Lee, Barbara L. Hempstead, Clay Bracken

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Single-male paternity in coelacanths (2013)

Kathrin P. Lampert; Katrin Blassmann; Karen Hissmann; Jürgen Schauer; Peter Shunula; Zahor el Kharousy; Benjamin P. Ngatunga; Hans Fricke; Manfred Schartl

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-20

Beschreibung: Article Deep-sea coelacanth female fish were thought to enhance genetic variability in their offspring by mating with multiple males. Here, Lampert et al. analyse the paternity of the offspring of two females, and present evidence that coelacanth females are in fact monogamous. Nature Communications doi: 10.1038/ncomms3488 Authors: Kathrin P. Lampert, Katrin Blassmann, Karen Hissmann, Jürgen Schauer, Peter Shunula, Zahor el Kharousy, Benjamin P. Ngatunga, Hans Fricke, Manfred Schartl

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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A peptide probe for targeted brown adipose tissue imaging (2013)

Ali Azhdarinia; Alexes C. Daquinag; Chieh Tseng; Sukhen C. Ghosh; Pradip Ghosh; Felipe Amaya-Manzanares; Eva Sevick-Muraca; Mikhail G. Kolonin

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-20

Beschreibung: Article Current methods to image brown adipose tissue rely on radioactive tracers and specialized imaging equipment. Here Azhdarinia et al. report a peptide-based probe that selectively binds to the vascular endothelium of brown adipose tissue and allows the near-infrared imaging of brown fat in mice. Nature Communications doi: 10.1038/ncomms3472 Authors: Ali Azhdarinia, Alexes C. Daquinag, Chieh Tseng, Sukhen C. Ghosh, Pradip Ghosh, Felipe Amaya-Manzanares, Eva Sevick-Muraca, Mikhail G. Kolonin

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Increasing functional modularity with residence time in the co-distribution of native and introduced vascular plants (2013)

Cang Hui; David M. Richardson; Petr Pyšek; Johannes J. Le Roux; Tomáš Kučera; Vojtěch Jarošík

Springer Nature

In: Nature Communications

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Publikationsdatum: 2013-09-20

Beschreibung: Article Understanding how species assemblages change over time is crucial for conservation. Here, the authors assess the changes of compartmentalized structure in native and alien species across millennia, and show that older assemblages can form more functionally distinctive modules than younger ones. Nature Communications doi: 10.1038/ncomms3454 Authors: Cang Hui, David M. Richardson, Petr Pyšek, Johannes J. Le Roux, Tomáš Kučera, Vojtěch Jarošík

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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