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  • Spektralphotometrie  (225)
  • Bone  (222)
  • Chromatographie, Dünnschicht  (138)
  • Neurosecretion  (85)
  • Springer  (668)
  • American Geophysical Union
  • Irkutsk : Ross. Akad. Nauk, Sibirskoe Otd., Inst. Zemnoj Kory
  • Krefeld : Geologischer Dienst Nordhein-Westfalen
  • Wiley
  • 2015-2019
  • 1975-1979  (359)
  • 1970-1974  (309)
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  • 1
    Digitale Medien
    Digitale Medien
    Radioautographic visualization of3H-fucose incorporation into glycoprotein by osteoblasts and its deposition into bone matrix (1979)
    Springer
    Calcified tissue international 27 (1979), S. 177-185 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Calcification ; Bone ; Glycoprotein ; Golgi ; Osteoblasts
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The elaboration of bone matrix glycoprotein by osteoblasts of alveolar bone was investigated by radioautography after the intravenous injection of3H-fucose into young rats. At selected times after injection, animals were sacrificed by intracardiac perfusion and demineralized specimens were prepared for light and electron microscope radioautography. At 5 and 10 min after injection, when the blood fucose level was high, silver grains were restricted to the spheroidal and cylindrical saccules of the Golgi apparatus. At 20 min membrane-limited secretory granules were also labeled. By 35 min, the blood fucose level had dropped and silver grains were detected over the apical cortical cytoplasm, in association with secretory granules located therein. Some grains were present over osteoblast processes and the adjacent prebone matrix. By 4 h most of the silver grains had left the cell. At that time they were observed over prebone, adjacent to osteoblast processes, as well as over the prebone-bone junction where a distinct band of label was noted. In demineralized preparations an electron-dense granular material was present at the prebone-bone junction in association with collagen fibrils. These findings provide evidence that osteoblasts in alveolar bone synthesize fucose-containing glycoprotein and indicate that the addition of3H-fucose occurs in the Golgi apparatus. The glycoprotein passes to the apical cortical cytoplasm by way of membrane-limited secretory granules, is exteriorized, and accumulates at the site where prebone transforms into bone (the prebone-bone junction). Since this is also the site of the calcification front, the deposition of labeled glycoprotein may be related to the deposition of bone mineral.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441182
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  • 2
    Digitale Medien
    Digitale Medien
    Bone fluoride concentrations associated with fluoridated drinking water (1979)
    Springer
    Calcified tissue international 27 (1979), S. 95-99 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Fluoride ; Analysis ; Food ; Age
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Recently published bone fluoride values from Iowa are very high compared to earlier reports, suggesting an increase in fluoride intake. Reanalysis of the Iowa specimens shows levels one-fourth those reported by the Iowa laboratory indicating an error in the original report. Seventeen bone specimens, collected from long-term residents of Rochester, New York, drinking 1 ppm F− water, had a mean value of 2085±270 ppm F− on an ashed-weight basis. This value is not significantly different from that predicted by the data of Zipkin et al. in 1958. These data, therefore, do not support the contention that there has been an increase in fluoride intake.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441168
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  • 3
    Digitale Medien
    Digitale Medien
    Use of a spectrophotometer for radiographic photodensitometry of bone (1979)
    Springer
    Calcified tissue international 28 (1979), S. 103-105 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Photodensitometry, X-ray ; Radiography ; Spectrophotometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary A conventional spectrophotometer was used to do radiographic photodensitometry of bone mass. An experiment to produce osteoporosis in guinea pigs required quantification of changes in bone mass. Lack of a densitometer necessitated finding another method for quantification. The method developed involved using industrial film in a closed X-ray system. Optical density of X-rays was then read in a spectrophotometer at nine femur locations. Highly significant correlations between optical density and femur calcium content and femur dry weight per millimeter were obtained. Histological sections from an animal with low optical density measurements confirmed bone loss by showing decreased cortical width and loss of trabecular bone. In addition to using readily available equipment, this method offers the advantage of being able to detect bone loss in specific areas of the bones. In addition, bones are left intact and can be used for other purposes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441227
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  • 4
    Digitale Medien
    Digitale Medien
    Analysis of paramagnetic centers in X-ray-irradiated enamel, bone, and carbonate-containing hydroxyapatite by electron spin resonance spectroscopy (1979)
    Springer
    Calcified tissue international 28 (1979), S. 107-112 
    Details
    ISSN: 1432-0827
    Schlagwort(e): ESR ; Bone ; Enamel ; CO3-Apatite ; Paramagnetism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Carbonate-containing hydroxyapatite, enamel, and bone were irradiated by an X-ray and investigated between 77° and 350°K by means of electron spin resonance (ESR) spectroscopy. The ESR spectrum of enamel irradiated at 77°K in vacuum and observed at the same temperature was almost the same as that of the carbonate-containing hydroxyapatite. The temperature dependence of signal intensities confirms a spin-energy exchange between the mineral and organic constituents in bone, but in enamel no or very little spinenergy exchange between the mineral and organic constituents. Considerable similarity among the ESR spectra of enamel, bone, and carbonate-containing apatite was obtained after X-ray irradiation in air at 300°K with both an X-band and a Q-band ESR spectrometer. The Q-band spectrum can be interpreted in terms of two paramagnetic species. One is identified as a CO 3 3− anion radical which has an axial symmetry withg factors of 2.0029 and 1.9972. The other species is found to be centered atg=2.0019.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441228
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  • 5
    Digitale Medien
    Digitale Medien
    On the solid state of bone (1979)
    Springer
    Calcified tissue international 28 (1979), S. 33-36 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Infrared, visible light ; Bone ; Collagen ; Apatite
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract Photovoltaic effect (infrared and visible light) is observed in bone and its two major components, collagen and apatite, at room temperature. A dimunition in the magnitude of photovoltage is observed after exposure to ultraviolet light in all the cases. The drift mobility of the charge carriers is obtained by measuring I versus V relationships in sandwich samples and relating them to the permitivity of the medium. Lifetime of the injected carriers is measured in the usual way. The data are consistent with the hypothesis that the effects are due to protonic conduction phenomena.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441215
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  • 6
    Digitale Medien
    Digitale Medien
    Growth of embryonic chick tibiae in ovo and in vitro: A scanning electron microscope study (1979)
    Springer
    Calcified tissue international 27 (1979), S. 33-40 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Chick embryo ; Bone ; Organ culture ; Scanning electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The study describes the ultrastructure of the mineralized portion of chick tibiae from 10 days in ovo to 2 days post-hatch. At 10 days a single mineralized cylinder surrounds the diaphysis. On its outer surface columnar trabeculae join to form ridges parallel to the long axis of the bone. These ridges are covered by another cylinder and form the haversian canals. At 11 days vascular invasion of the marrow cavity occurs and resorption of the endosteal surface begins. This type of periosteal deposition and endosteal resorption is repeated during and subsequent to embryonic development. The mineralized portion of 10-day chick tibiae cultured for 2 days in modified BGJ medium was compared with 10-, 11-, and 12-day tibiae in ovo. Cultured tibiae were similar in length and calcium content to 11-day tibiae in ovo. The form of mineral deposited in ovo and in culture was the same, namely, aggregates of spherical mineral clusters. Differences in culture included the following: (a) few concentric cylinders were deposited as compared with tibiae in ovo; (b) trabeculae were not arranged in rows and ridges in culture; (c) osteocytic lacunae were restricted to bases of trabeculae rather than uniformly distributed as in ovo; and (d) the endosteal surface of tibiae in culture appeared etched.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441158
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  • 7
    Digitale Medien
    Digitale Medien
    An ultrastructural study of the role of calcification nodules in the mineralization of woven bone (1979)
    Springer
    Calcified tissue international 27 (1979), S. 57-64 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Bone formation ; Calcification ; Calcification nodule ; EM
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Osteolathyrism has been used as an experimental model for the study of calcification nodules during the mineralization process. Periosteal exostoses developing in osteolathyrism characteristically have spherical basophilic structures (calcification nodules) in the vicinity of developing bone spicules. In thin sections, the nodules were seen scattered between collagen fibers in the intercellular matrix. Collagen fibers did not appear to be present within the nodules but sometimes were packed just outside them. Matrix vesicles were also present in areas of early mineralization. After EDTA decalcification, the majority of the nodules consisted of a fine granular material surrounded by an electron-dense peripheral zone. The peripheral dense zone was occasionally incomplete in small nodules in areas of early mineralization. An electron-dense central area could be observed in the center of the nodules. Evidence has been presented indicating that the calcification nodules arise from smaller mineralization foci, presumably matrix vesicles. The calcification nodules enlarge to approximately 1.0 µm in size, at which point development is slowed or halted allowing the formation of the peripheral dense zone. Although coalescence of nodules was observed, this was more a random event. The further mineralization of the trabeculae was achieved by the calcification of the collagen fibers. The mineralized trabeculae reflected this pattern of nodular and collagenous calcification. It is suggested that this pattern of calcification is characteristic of rapidly developing woven bone.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441162
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  • 8
    Digitale Medien
    Digitale Medien
    Age-related changes in the density and tensile strength of human femoral cortical bone (1979)
    Springer
    Calcified tissue international 27 (1979), S. 105-108 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Femur ; Strength ; Density ; Age
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary In order to ascertain whether the intrinsic strength of human bone changes with age or not, we have determined the ultimate tensile strength and density of strips of femoral cortical bone. These femora were collected from cadavers varying in age from 13 to 97 years. The results show that both density and intrinsic strength of bone increase up to about the fourth decade of life and then decrease with age. However, the rate of decrease of strength is greater than that of density. This indicates that the density of bone is not the sole determining factor of its strength, and that some other factors play an important part.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441170
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  • 9
    Digitale Medien
    Digitale Medien
    Distribution of the perilacunar hypomineralized areas in cortical bone from patients with familial hypophosphatemic (vitamin D-resistant) rickets (1979)
    Springer
    Calcified tissue international 27 (1979), S. 101-104 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Rickets ; Hypophosphatemia ; Microradiography ; D-resistance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The perilacunar areas of low mineral density in microradiographs from cortical bone of patients with hypophosphatemic (vitamin D-resistant) rickets are not evenly distributed throughout the bone tissue. Their frequency and distribution were determined in bone from 9 patients with this disease. It was found that the lesion was more frequent in haversian bone than in interstitial bone, and along the inner circumference of growing haversian systems as compared with the outer circumference. These findings indicate that the lesion is the result of retarded mineralization, and that mineralization slowly proceeds in these areas as the bone becomes older. A relatively high frequency of the lesion was also found in osteons with an elliptical cross section along the long axis of the ellipse. The cause of the abundance of the lesion at these sites is not clear, but it is possible to explain the uneven distribution in elliptical osteons by assuming an unequal rate of bone formation in these structures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441169
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  • 10
    Digitale Medien
    Digitale Medien
    Effect of carbon dioxide and various oxygen tensions on the respiratory activity of bone (1979)
    Springer
    Calcified tissue international 27 (1979), S. 165-169 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Oxygen uptake ; Bone ; Oxygen tension ; Carbon dioxide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The present study was carried out to determine the influence of carbon dioxide and oxygen tension on the respiratory activity of bone cells in mouse calvaria in vitro. Five-day-old mouse calvaria were removed aseptically and incubated individually for 1 h at 37° C in a closed reaction chamber containing 1.5 ml of tissue culture medium made up of 60% horse serum in Gey's solution containing 100 unit/ml penicillin and 100µg/ml streptomycin. Before the calvaria were added, the medium in the incubation chamber was equilibrated with 10%, 20%, 30%, or 50% oxygen balanced with nitrogen. The effect of CO2 on oxygen utilization by the calvaria was determined by incubating the calvaria in a medium previously equilibrated with either 50% O2 balanced with N2 or 50% O2 and 5% CO2 balanced with N2. At each oxygen tension, the rate of oxygen utilization by the calvaria was measured polarographically by a Clark oxygen electrode. The results showed that the rate of oxygen uptake of bone increased as the oxygen tension increased and carbon dioxide stimulated significantly the rate of oxygen utilization by the bone cells. In view of the previous reports that both carbon dioxide and oxygen tension are implicated in the process of bone resorption, it is suggested that these two factors may affect bone resorption by influencing the oxygen utilization by bone cells and ultimately controlling their energy metabolism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441180
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  • 11
    Digitale Medien
    Digitale Medien
    X-ray diffraction of the calcified tissues inPolypterus (1979)
    Springer
    Calcified tissue international 28 (1979), S. 37-42 
    Details
    ISSN: 1432-0827
    Schlagwort(e): X-ray diffraction ; Hydroxyapatite ; Whitlockite ; Fish (Pisces) ; Bone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Pyrolyzed scales, fin spines, and bone from the ray-finned bony fishPolypterus (Actinopterygii) showed two mineral phases on X-ray diffraction: hydroxyapatite (HA), Ca5(PO4)3OH, and whitlockite, Ca3(PO4)2. The ratio of HA/whitlockite varied with the structure (scale, spine, bone) within each individual fish. The relative proportions of HA to whitlockite in pyrolyzed samples reflected the Ca/P ratio of the sample. Whitlockite appears after pyrolysis when the Ca/P is lower than 1.67. Among the five fish investigated, for each structure a general trend was noted. The proportion of HA relative to whitlockite increased with size (age) of the fish. Thus the smallest fish, a juvenile, exhibited a low Ca/P mineral in its calcified tissues, whereas the larger fish had progressively more HA and less whitlockite.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441216
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  • 12
    Digitale Medien
    Digitale Medien
    Disordered mineral metabolism produced by ketogenic diet therapy (1979)
    Springer
    Calcified tissue international 28 (1979), S. 17-22 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Anticonvulsant ; Ketogenic diet ; Calcium ; Vitamin D ; Bone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Vitamin D and mineral metabolism status was examined in five children maintained chronically on combined ketogenic diet-anticonvulsant drug therapy (KG), and the results compared to those obtained in 18 patients treated with anticonvulsant drugs alone (AD) and 15 normal controls. KG patients exhibited biochemical findings of vitamin D deficiency osteomalacia: decreased serum 25-hydroxyvitamin D (25OHD) and calcium concentrations, elevated serum alkaline phosphatase and parathyroid hormone concentrations, decreased urinary calcium and increased urinary hydroxyproline excretion, and decreased bone mass. Although the KG and AD groups demonstrated similar reductions in serum 25OHD concentration, the KG patients exhibited a significantly greater reduction in bone mass. In response to vitamin D supplementation (5000 IU/day), mean bone mass in the KG group increased by 8.1±0.9% (P〈0.001) over a 12-month period. These results suggest that ketogenic diet and anticonvulsant drug therapy have additive deleterious effects on bone mass and that these effects are partially reversible by vitamin D treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441213
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  • 13
    Digitale Medien
    Digitale Medien
    Effects of osteoclast activating factor from human lymphocytes on cyclic AMP concentrations in isolated mouse bone and bone cells (1979)
    Springer
    Calcified tissue international 28 (1979), S. 23-32 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Bone cells ; Cyclic AMP ; Osteoclast activating factor ; Lymphokine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Osteoclast activating factor (OAF) is a lymphokine which may participate in the pathologic destruction of bone observed in a number of disorders. In the current studies, we investigated the action of OAF on cAMP accumulation by bones and isolated bone cells in culture. OAF was shown to stimulate accumulation of cAMP in mouse cranial bones at doses between 1 and 1000 ng/ml. Stimulation of bone resorption was observed in bones treated with the same doses of OAF. In order to investigate the cell types responsible for cAMP responses to OAF, we isolated bone cells and grew them in monolayer culture. The cells were isolated by a variety of techniques which separate bone cells into two types of parathyroid hormone (PTH)-responsive populations: (a) cells derived from the periosteal regions of the bone, which also respond to calcitonin with increases in cAMP; and (b) cells derived from the matrix, which do not respond to calcitonin. OAF caused elevation of cAMP levels in both the periosteum-derived cells and the matrix-derived cells. The magnitudes and time courses of OAF effects in these populations resembled the effects previously reported for PTH in the same populations. OAF stimulated adenyl cyclase in both types of cell populations, but did not produce significant changes in cAMP phosphodiesterase activity. OAF differed from PTH in that its effects on cAMP accumulation decreased sharply at supramaximal doses in both bone and isolated cells, especially in the matrix-derived populations. Bone resorption did not decrease as markedly as did cAMP accumulation at high doses of OAF, suggesting that cAMP accumulation and resorption could be dissociated under some conditions. These results indicate that OAF has effects on cAMP production in the same cell populations as PTH, and suggest that OAF could modify not only resorption but also formation of bone in vivo. OAF may exert its effects on bone by means of cAMP-dependent mechanisms, but more data will be necessary to establish this unequivocally. The observed differences between OAF and PTH may be of relevance in the mechanism and treatment of pathologic bone destruction in vivo.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441214
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  • 14
    Digitale Medien
    Digitale Medien
    Bone metabolism, parathyroid hormone, and calcitonin in paraplegia (1979)
    Springer
    Calcified tissue international 27 (1979), S. 199-204 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Parathyroid hormone ; Calcitonin ; Osteoporosis ; Paraplegia ; Hydroxyproline
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary In paraplegia, osteoporosis below the neurological lesion occurs early after the spinal cord affection. The serum levels of parathyroid hormone (PTH) and calcitonin (CT), using a radioimmunoassay for the measurement of immunoreactivity, were studied in 12 paraplegic patients for 9 months following onset. Serum Ca and P levels, urinary hydroxyproline excretion, and the kinetic metabolic clearance of45Ca have also been measured. P and immunoreactive (i) CT levels were found the highest at the beginning of the observation and progressively decreased with time. Ca and iPTH serum levels varied inversely with time, the highest level of Ca and the lowest level of iPTH being recorded at the third month following the paraplegia. Mean values of Ca, iPTH, and iCT were in the normal range throughout the study. P levels were increased during the first 3 months. Hydroxyprolinuria was also high and45Ca kinetics showed increased values of Vt, Vo+, and Vu. These parameters indicate a high degree of bone turnover. The results were consistent with the assumption that PTH is not responsible for the increased resorption of bone in paraplegia. Likewise, a deficiency of CT does not seem to be responsible for this bone resorption. These endocrine modifications could be secondary to an increase in the calcium flux from bone to blood and resulting from bone destruction as attested by the increase of urinary calcium and urinary hydroxyproline excretion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441186
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  • 15
    Digitale Medien
    Digitale Medien
    Bone maturation in the vitamin D, phosphate deficient rat and the response to acid loading (1979)
    Springer
    Calcified tissue international 27 (1979), S. 233-237 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Vitamin D ; Acidosis ; Phosphate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Vitamin D and phosphate deficiency were produced in rats in order (a) to evaluate the degree of bone mineral and matrix maturation using a bromoform/toluene density gradient technique; and (b) to compare the aforementioned bone maturational changes due to vitamin D and phosphate deprivation to those produced with superimposed severe acidosis. Rats were fed a diet deficient in vitamin D and phosphorus (0.2%) from 3 weeks through 7 weeks of age. To examine the additional contribution of dietary calcium, we gave one-half of the animals either a low (0.06%) or high (1.3%) calcium diet. Following the 4 weeks of vitamin D deficiency, one-half of each group was given 1.8% NH4Cl in the drinking water for 4 succeeding days to induce an acute, severe acidosis. The degree of bone maturation was quantitated via bromoformtoulene density gradient fractionation; total mineral and hydroxyproline (collagen) levels were quantitated as well. The vitamin D-deficient rats deprived of adequate dietary phosphate responded by conserving phosphorus, and as a consequence total bone phosphorus levels were maintained within that level for control rats. This conservation was independent of calcium intake but was extremely sensitive to acute acid loading, where a significant reduction in total bone phosphorus was noted. The bone maturational profile obtained from the vitamin D-phosphate deficient rats, however, revealed a significant accumulation of less mature or dense bone collagen and mineral with a corresponding decrease in the most mature or dense moieties. In contrast to the reduction of the total bone phosphorus content by acute acidosis, the skeletal collagen-mineral maturational profile was not significantly affected by the short-term systemic acidosis. The observed retardations in the bone collagen and mineral maturation of the vitamin D-deficient, phosphate-deprived state provide an additional observation which may well relate to the progressive osteopenia documented in states of chronic, mild acidosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441191
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  • 16
    Digitale Medien
    Digitale Medien
    Changes in proline synthetic and degradative enzymes during matrix-induced cartilage and bone formation (1979)
    Springer
    Calcified tissue international 27 (1979), S. 275-279 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Proline ; Cartilage ; Bone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Proline biosynthetic and degradative enzymes are unevenly distributed in differentiated mammalian tissues. Activities of the synthetic enzymes are relatively high in collagenous tissues, whereas activities of the degradative enzymes are high in noncollagenous tissues. In order to further characterize tissue-specific proline biosynthesis and degradation, we have determined proline enzyme activities during cartilage and bone formation induced by demineralized bone matrix. We can thus follow temporal changes in enzyme activity in a single tissue as different cell types develop. Ornithine aminotransferase and pyrroline-5-carboxylate reductase have peaks of activity which correlate with maximal type II collagen synthesis by chondrocytes. Both enzymes also are active during bone formation. In contrast, proline oxidase and pyrroline-5-carboxylate dehydrogenase are present at low levels and do not change as new cell types appear. Arginase activity peaks during the first 3 days and then rapidly decreases by the time cartilage and bone formation begin. These observations further substantiate the importance of proline biosynthesis in collagenous tissues. The close correlation between ornithine aminotransferase activity and type II collagen synthesis suggests that the pathway from ornithine to proline may be especially important during formation of type II collagen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441197
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  • 17
    Digitale Medien
    Digitale Medien
    Noninvasive measures of bone bending rigidity in the monkey (M. nemestrina) (1979)
    Springer
    Calcified tissue international 27 (1979), S. 109-115 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Bending rigidity ; Disuse atrophy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The in vivo bending rigidity and bone mineral content of monkey ulnae and tibiae were measured. Bending rigidity in the anteroposterior plane was measured by an impedance probe technique. Forced vibrations of the bones were induced with an electromechanical shaker, and force and velocity at the driving point were determined. The responses over the range of 100–250 Hz were utilized to compute the bending rigidity. Bone mineral content in the cross section was determined by a photon absorption technique. Seventeen male monkeys (Macaca nemestrina) weighing 6–14 kg were evaluated. Repeatability of the rigidity measures was 4%. Bone mineral content was measured with a precision of 3.5%. Bending rigidity was correlated with the mineral content of the cross section,r=0.899. Two monkeys were evaluated during prolonged hypodynamic restraint. Restraint produced regional losses of bone most obviously in the proximal tibia. Local bone mineral content declines 17 to 24% and the average bending rigidity declines 12 to 22%. Changes in bones leading to a reduction in mineral content and stiffness are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441171
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  • 18
    Digitale Medien
    Digitale Medien
    Anticonvulsant drug-induced osteomalacia: Alterations in mineral metabolism and response to vitamin D3 administration (1979)
    Springer
    Calcified tissue international 27 (1979), S. 13-18 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Anticonvulsants ; Calcium ; Vitamin D ; Parathyroid hormone ; Bone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Parameters of mineral metabolism were examined in 6 patients with moderately severe anticonvulsant drug-induced osteomalacia. Compared to 15 matched controls, the patients exhibited significantly reduced serum calcium, inorganic phosphate, and 25-hydroxyvitamin D concentration, elevated serum alkaline phosphatase and immunoreactive parathyroid hormone (iPTH) concentration, reduced intestinal47Ca absorption, reduced urinary calcium and increased urinary hydroxyproline excretion, and reduced forearm bone mass. Intestinal absorption of vitamin D3 was normal. Following 4 months of treatment with vitamin D3 (4000 units/day), serum 25-OHD concentration was increased to 3 times mean normal values and all parameters except serum iPTH, urinary calcium excretion, and forearm bone mass were returned to levels not significantly different from normal. Serum iPTH concentration was reduced by 39% (P〈0.05); 24-h urinary calcium excretion rose by 98% (P〈0.001), and forearm bone mass increased by 5.6% (P〈0.05). It is concluded that moderate-dose vitamin D3 supplementation is effective in normalizing parameters of mineral metabolism in this disorder, despite evidence of resistance to the biologic effects of vitamin D.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441155
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  • 19
    Digitale Medien
    Digitale Medien
    The calciuria of increased fixed acid production in humans: Evidence against a role for parathyroid hormone and 1,25(OH)2-vitamin D (1979)
    Springer
    Calcified tissue international 28 (1979), S. 233-238 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Calcium ; PTH ; 1,25(OH)2D ; Acid ; Bone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary We measured mineral and acid balances, serum iPTH, urinary cAMP/creatinine, and plasma concentrations of 25OHD and 1,25(OH)2D in 7 healthy adults during control conditions and during increased fixed acid production achieved either by the administration of NH4Cl (N=3) or by increased dietary protein intake (N=4). When acid production was increased, the subjects were in positive acid balance and negative Ca balance because of increased urinary Ca excretion. Serum iPTH fell slightly but urinary cAMP and the plasma levels of vitamin D metabolites did not change. We conclude that the accelerated skeletal and urinary losses of Ca that occur when fixed acid production is increased are not contributed to nor compensated for by the parathyroid-vitamin D endocrine systems.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02441241
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  • 20
    Digitale Medien
    Digitale Medien
    The occurrence of chondroitin-6-sulphate in adult human compact bone tissue (1979)
    Springer
    Calcified tissue international 29 (1979), S. 169-171 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Glycosaminoglycans ; Bone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Compact bone tissue chondroitin sulphate, previously considered to be pure chondroitin-4-sulphate, was isolated from three adult human femoral diaphyses and digested with chondroitinase ABC. Assaying these digests by means of high performance liquid chromatography we could demonstrate that 12 to 14% of the disaccharide residues were 6-sulphated. The 4/6-ratios were also studied in chondroitin sulphate fractions of different molecular size. Slightly increasing amounts of 6-sulphated disaccharides were found with increasing size of the chondroitin sulphates.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02408073
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  • 21
    Digitale Medien
    Digitale Medien
    Effects of changing hydrogen ion, carbonic acid, and bicarbonate concentrations on bone resorption in vitro (1979)
    Springer
    Calcified tissue international 29 (1979), S. 7-13 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Culture ; Resorption ; Acidosis ; Alkalosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary We have examined the effects of H+, CO2, and HCO3 − concentrations during metabolic and respiratory acidosis and alkalosis on bone resorption in vitro. Rat fetal bones prelabeled with45CaCl2 were cultured at 2%, 5%, and 10% CO2 for up to 120 h, and the release of45Ca was measured in devitalized bones (non-cell-mediated45Ca release) and in live bones (cell-mediated45Ca release) cultured with or without PTH and 1,25(OH)2D3. Non-cell-mediated mineral loss was linearly related to H+ concentration but not to CO2 or HCO3 − concentration. This effect was observed on both labeled and stable calcium. Over a wide pH range (6.9–7.5) H+, CO2, or HCO3 − concentrations did not influence cell-mediated bone resorption in control or in PTH-and 1,25(OH)2D3-stimulated cultures. However, inhibition of cell-mediated bone resorption was observed at higher or lower pH irrespective of CO2 or HCO3 − concentrations. These observations demonstrate that the bone mineral mobilizing effect of acidosis in vitro is mainly due to the effect of changing H+ concentration on devitalized bone. Effects on cell-mediated bone resorption and hormonal response were observed only at extremes of pH. The effects of H+ were independent of changes in CO2 or HCO3 − concentration and could be responsible for the negative calcium balance and increased urinary loss observed in metabolic acidosis in vivo, but do not explain the reported differences in effects on calcium metabolism between respiratory and metabolic acidosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02408049
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  • 22
    Digitale Medien
    Digitale Medien
    Electrothermal AAS studies of Sm, Eu, Dy, and Er separated from uranium (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 298 (1979), S. 367-372 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Lanthaniden, Europium, Dysprosium, Erbium, Samarium in Uran ; Spektralphotometrie ; Atomabsorption ; Graphitofen
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Summary Studies were conducted on the assay of Sm, Eu, Dy and Er separated from uranium using aqueous standards by electrothermal AAS with Massmann type graphite furnace. The working curves were found to be linear in the ranges Sm (1–10 μg/ml), Eu (0.05–0.6 μg/ml), Dy (0.1–0.8 μg/ml) and Er (0.1–1.0 μg/ml). The values obtained for synthetic samples agreed favourably with those obtained by emission spectrographic method. Experiments using pyrolytic carbon coated tubes with and without pretreatment by La, Ta and Y have shown an enhancement with treatment upto a maximum of 15% and improve the memory effect marginally. The effect of Ta treatment was found to be singularly useful in improving the general behaviour of Sm. The interference effects of lanthanides, other than the analyte, were found to be negligible. However, the presence of uranium was found to affect the absorbance. The absorbance of Eu was found to be nearly independent of uranium after an initial increase. On the other hand, the absorbance of other elements studied was found to drastically decrease after an initial enhancement. Detailed investigations of temperature dependence of absorbance were carried out using Eu, Dy and Er. The differences in the behaviour of these elements is attributed to probable differences in the modes of their atomization.
    Notizen: Zusammenfassung Die Untersuchungen wurden mit Hilfe des Graphitrohrofens nach Maßmann durchgeführt. In folgenden Bereichen ergaben sich lineare Eichkurven: Sm 1–10 μg/ml, Eu 0,05–0,6 μg/ml, Dy 0,1–0,8 μg/ml, Er 0,1μ-1,0 μg/ml. Die aus synthetischen Proben erhaltenen Ergebnisse stimmten gut mit den durch Emissionsspektrographie erhaltenen überein. Versuche wurden mit Röhren mit pyrolytischen Kohlenstoffüberzug mit und ohne Vorbehandlung durch La, Ta und Y durchgeführt und ergaben eine bis 15%ige Steigerung durch die Behandlung sowie eine mäßige Besserung des Memoryeffektes. Eine Behandlung mit Ta war besonders für Sm vorteilhaft. Störungen durch andere Lanthanide waren vernachlässigbar. Uran beeinflußte jedoch die Absorption. Im Falle von Eu zeigte sich nach anfänglicher Zunahme fast eine Unabhängigkeit, während bei den anderen untersuchten Elementen nach anfänglicher Zunahme eine beträchtliche Abnahme auftrat. Mit Eu, Dy und Er wurde ebenfalls die Temperaturabhängigkeit der Absorption untersucht. Festgestellte Unterschiede im Verhalten werden auf unterschiedliche Atomisierung zurückgeführt.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00482016
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  • 23
    Digitale Medien
    Digitale Medien
    Spectrophotometric determination of uranium(VI) with Chlorophosphonazo III after tri-n-octylamine extraction (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 284-284 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Uran(VI) mit Chlorphosphonazo III ; Spektralphotometrie ; Trioctylamin-Extraktion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481652
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  • 24
    Digitale Medien
    Digitale Medien
    Indirect spectrophotometric determination of phosphate using the reaction between cerium(III) and xylenol orange (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 285-285 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Phosphat in Ferrosilicium ; Spektralphotometrie ; Cer/Xylenolorange, indirekt
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481654
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  • 25
    Digitale Medien
    Digitale Medien
    Identification and detection of carbamate pesticides in autopsy tissues using thin-layer chromatography (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 287-287 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Nachw. von Carbamatpesticiden in biolog. Material ; Chromatographie, Dünnschicht
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481656
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  • 26
    Digitale Medien
    Digitale Medien
    Information content and equivocation of TLC identification procedures (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 361-365 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Chromatographie, Dünnschicht ; Informationsgehalt und »Äquivokation«
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Summary A method has been developed for the calculation of information contents of one-channel identification procedures, which is especially applicable in the area of thin-layer chromatography (TLC). The method can be considered as a refinement of the one proposed by Massart and can easily be extended to the combination of one-channel procedures. In addition, the quantity ‘equivocation’, which is complementary to the information content, is introduced. As an example the best TLC-systems and the best combinations of two TLC-systems for the identification of DDT and twelve related compounds are selected by using information contents or equivocations. The results for the individual systems are compared with those obtained by Massart.
    Notizen: Zusammenfassung Eine Methode zur Berechnung von Informationsgehalten von Einkanal-Identifizierungsverfahren wurde entwickelt, die besonders gut für das Gebiet der Dünnschicht-Chromatographie (DC) anwendbar ist. Sie kann als eine Verfeinerung der von Massart vorgeschlagenen Methode angesehen werden und kann auf einfache Weise für Kombinationen von Einkanal-Verfahren erweitert werden. Dabei wird der Begriff »Äquivokation«, komplementär zum Informationsgehalt, eingeführt. Als Beispiel wurden die besten DC-Systeme und Kombinationen von zwei DC-Systemen für die Identifizierung von DDT und zwölf verwandten Verbindungen unter Benutzung von Informationsgehalten oder »Äquivokationen« ausgewählt. Die Ergebnisse für die einzelnen Systeme werden mit den nach Massart gefundenen verglichen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00468523
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  • 27
    Digitale Medien
    Digitale Medien
    TLC separation of potential antithyroid agents: N-aryl-N′-benzenesulphonylthiocarbamides (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 407-407 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Trenn. von Arylbenzolsulfonylthiocarbamiden ; Chromatographie, Dünnschicht
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00468534
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  • 28
    Digitale Medien
    Digitale Medien
    Extraction and spectrophotometric determination of cobalt as pyridine-azide mixed ligand complex (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 413-413 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Kobalt mit Pyridin und Azid ; Spektralphotometrie ; Aussalzungsmittel, Mischkomplex
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00468540
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  • 29
    Digitale Medien
    Digitale Medien
    Indirect photometric determination of microamounts of cerium(IV) using iron(III)-resacetophenone oximate complex (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 270-270 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Cer(IV) ; Spektralphotometrie ; indirekt, Fe(III)-Resacetophenonoximat-Komplex
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481492
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  • 30
    Digitale Medien
    Digitale Medien
    Zum Einsatz der Anthronmethode für die Kohlenhydratbestimmung in Huminsäuren (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 299 (1979), S. 264-266 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Kohlenhydraten in Huminsäuren ; Spektralphotometrie ; Anthronmethode
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Eine modifizierte Anthronmethode zur Bestimmung des Kohlenhydratgehaltes in Fraktionen von Huminsäure-Blei(II)-Chelatverbindungen, die mit chemischen und gelchromatographischen Methoden getrennt wurden, wird beschrieben. Um die Störung der Methode durch die Absorption der Huminsäuren, die mit abnehmender Wellenlänge ansteigt, gering zu halten, wird die Extinktion des Anthron-Kohlenhydrat-Reaktionsproduktes bei 620 nm gemessen. Die Huminsäurekonzentration darf 0,1 g/dl nicht überschreiten. Da die molare Extinktion des Anthron-Reaktionsproduktes von der Art des Kohlenhydrates abhängt, wird der Kohlenhydratgehalt auf das Hauptkohlenhydrat des Huminsäurehydrolysats berechnet (d.h. Glucose).
    Notizen: Summary A modified anthrone method is described for the determination of carbohydrates in fractions of lead(II)-chelate compounds of humic acids separated with chemical as well as gel-chromatographic methods. To reduce the disturbance of the method by the absorption of humic acids increasing with the decrease of wavelength, the absorbance of the anthronecarbohydrate reaction products is measured at 620 nm and the humic acid concentration is not allowed to exceed 0.1 g/dl. Because the molar absorptivity of the anthrone reaction-products depends on the type of carbohydrate investigated, the content is calculated for the main carbohydrate of the humic-acid hydrolysate (i.e. glucose).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00488414
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  • 31
    Digitale Medien
    Digitale Medien
    Formazane als funktionelle Gruppen chelatbildender Ionenaustauscher. I (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 366-370 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Quecksilber, Silber mit Formazanen ; Spektralphotometrie ; chelatbildende Ionenaustauscher
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die Darstellung substituierter Formazane und ihre chemische Fixierung an Cellulose, amino- und chlormethyliertem Polystyrol wird beschrieben. Die Kapazitäten der Austauscher liegen zwischen 0,05 mÄq/g (Cellulose) und 0,6 mÄq/g (Polystyrol). In neutralem Medium zeigen sie eine besondere Affinität zu Hg(II), Pd(II) und Ag(I), aber keine Affinität zu Cu(II). Weiterhin wurde eine spektrophotometrische Bestimmung von Hg(II) und Ag(I) mit dem wasserlöslichen Formazan (FII)-NO2 ausgearbeitet [Hg(II): ɛ546=23 000 l Mol−1 cm−1, Ag(I): ɛ546 =38 000 l Mol−1 cm−1].
    Notizen: Summary The preparation of substituted formazans and their fixation on cellulose, amino- and chloromethylated polystyrene is described. The capacities of the exchangers vary from 0.05 meq/g (cellulose) to 0.6 meq/g (polystyrene). They show in neutral medium greater affinity to Hg(II), Pd(II) and Ag(I), but no affinity to Cu(II). Further, a spectrophotometric determination of Hg(II) and Ag(I) with the watersoluble formazan (FII)-NO2 has been worked out. [Hg(II): ɛ546=23 000 l Mol−1 cm−1, Ag(I): ɛ546=38 000 l Mol−1 cm−1].
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00539705
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  • 32
    Digitale Medien
    Digitale Medien
    Universelle, halogenfreie DC-Fließmittel für Arzneisubstanzen (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 398-401 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Analyse von pharmazeut. Produkten ; Chromatographie, Dünnschicht ; halogenfreie Fließmittelsysteme
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Mit 2 sauren, 2 basischen und einem neutralen Fließmittel mit unterschiedlichen Polaritäten und guten Trennleistungen konnten 151 von 157 geprüften Arzneisubstanzen mit hRf-Werten zwischen 10 und 90 chromatographiert werden.
    Notizen: Summary Using two acidic, two alkaline and a neutral mobile phase of different polarities and high separation efficiencies 151 of 157 tested drug substances could be chromatographed with hRf-values between 10 and 90.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00539712
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  • 33
    Digitale Medien
    Digitale Medien
    Die Mechanisierung der photometrischen Analyse mit den Bausteinen der Flüssigkeits-Chromatographie (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 356-360 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Spektralphotometrie ; Mechanisierung, Prinzip, Optimierung
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Das Prinzip der Automatisierung der photometrischen Analyse mit kontinuierlichem Reagentienfluß und die speziellen Vorteile der Verwendung von Bausteinen der Flüssigkeits-Chromatographie werden ausführlich diskutiert. Die Optimierung folgender Parameter wird besprochen: Verweilzeit (Reaktionszeit), Einspritzmenge, Pumpgeschwindigkeit, Säulenabmessungen, Partikeldurchmesser.
    Notizen: Summary The principle of automation of photometric analysis by the continuous flow method and the particular advantages of the use of component parts of liquid chromatography are discussed in detail. The optimization of the following parameters is pointed out: residence (reaction) time, injection volume, pumping rate, column dimensions and particle diameter.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00468522
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  • 34
    Digitale Medien
    Digitale Medien
    Zur Veränderung der Fluorescenzintensität polycyclischer Aromaten auf Dünnschichtplatten (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 24-29 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Polycyclen in Wasser ; Chromatographie, Dünnschicht ; Änderung der Fluorescenzintensität
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Nach der Verordnung über Trinkwasser und Brauchwasser für Lebensmittelbetriebe (Trinkwasserverordnung) vom 31. Januar 1975 müssen 6 Einzelverbindungen aus der Gruppe der polycyclischen aromatischen Kohlenwasserstoffe nachgewiesen werden. Das empfohlene Analysenverfahren basiert auf der Messung der Fluorescenz nach vorangegangener chromatographischer Trennung auf Adsorberschichten. Sowohl bei dieser Trennung als auch in der anschließenden Zeit verändert sich die Fluorescenzintensität einzelner Verbindungen z.T. beträchtlich. Systematische Untersuchungen an Kieselgel und an Mischschichten aus Aluminiumoxid und Acetylcellulose sollen die kritischen Punkte und die möglichen Fehlerquoten offen legen.
    Notizen: Summary According to the regulation on the use of drinking and industrial water in food industry (Drinking Water Regulation) of 31 January, 1975, six individual compounds of the group of polycyclic aromatic hydrocarbons must be traced. The analytical procedure recommended is based on the measurement of fluorescence after preceding Chromatographic separation on adsorber layers. In the course of this separation and during the time that follows, the fluorescence intensity of various compounds changes, in some cases considerably. Systematic studies with silica gel and mixed layers of aluminium oxide and acetyl cellulose are intended to reveal critical points and possible ranges of error.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00490944
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  • 35
    Digitale Medien
    Digitale Medien
    Spectrophotometric determination of vanadium in steel with N-Hydroxy-N-phenyl-N′-p-tolylbenzamidine (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 47-47 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Vanadium in Stahl ; Spektralphotometrie ; Hydroxyphenyl-p-tolylbenzamidin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00490948
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  • 36
    Digitale Medien
    Digitale Medien
    Analytische Bestimmung von Aniontensiden in Schweb- und Sinkstoffen sowie Klärschlämmen (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 393-397 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Tensiden in Wasser ; Spektralphotometrie ; Aniontenside, Reinigungsstufen
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Aniontenside werden an Feststoffen der Gewässer wie auch der Kläranlagen adsorbiert und teilweise angereichert. Ihre analytische Bestimmung erfordert eine mehrstufige Vorarbeit. Sie führt über die Extraktion des Probengutes, die Abtrennung der Tenside von Störstoffen durch Ausblasen (grobe Vorreinigung) und die chromatographische Reinigung der Rohfraktion auf Kieselgelschichten. Die Konzentration der reinen Tensidfraktion kann colorimetrisch oder IR-spektrometrisch bestimmt werden.
    Notizen: Summary Anion tensides are adsorbed on solids in surface waters and sewage treatment plants and enriched to some extent. Their analytical determination requires multi-stage preparations, including sampling, separation of the tensides from disturbing material by air stripping (rough preliminary cleaning), and chromatographic cleaning of the raw fraction on silica gel. The concentration of the pure tenside fraction can be determined colorimetrically or by way of IR spectrometry.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00539711
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  • 37
    Digitale Medien
    Digitale Medien
    Zur Chromatographie von Metallchelaten (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 297 (1979), S. 138-143 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Trenn, der Metallchelate von 8-Mercaptochinolin ; Chromatographie, Dünnschicht
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung 8-Mercaptochinolin (Thiooxin) eignet sich zum Nachweis und zur Trennung von Metallen mit Hilfe der Dünnschicht-Chromatographie. Es bildet Neutralkomplexe definierter Zusammensetzung, die in wäßriger Phase schwerlöslich sind und in Chloroform extrahiert werden können. Fällung und Extraktion sind vom pH-Wert abhängig, wodurch eine Vortrennung der Metalle möglich ist. Beschrieben wird das dünnschicht-chromatographische Verhalten von 17 Metallchelaten. Die intensive Eigenfärbung der Komplexe erübrigt den Gebrauch von Anfärbereagentien. Die visuelle Nachweisgrenze der Metalle liegt zwischen 5 und 20 ng (Fluorescenzlöschung bei 254 nm). Spektralphotometrische Auswertung der Chromatogramme läßt eine Erniedrigung der Nachweisgrenze um etwa eine Zehnerpotenz erwarten.
    Notizen: Summary 8-Mercaptoquinoline (thiooxine) is qualified for the detection and separation of metals by thin-layer chromatography. It forms neutral complexes in definite composition, which are insoluble in aqueous solution, but readily soluble in CHCl3. Precipitation and extraction are dependent on the pH value, whereby pre-separation of metals is possible. The thin-layer chromatographic behaviour of 17 metal chelates is described. No spraying is necessary for detection, since the complexes show different, characteristic colours. The visual detection limits of the metals are between 5 and 20 ng (fluorescence quenching at 254 nm). Spectrophotometric determination of the chromatograms lowers the detection limit by one power of ten.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00483594
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  • 38
    Digitale Medien
    Digitale Medien
    Zur Chromatographie von Metallchelaten (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 297 (1979), S. 144-147 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Trenn. der Metallchelate von 1-Hydroxy-2-pyridinthion ; Chromatographie, Dünnschicht
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung 1-Hydroxy-2-pyridinthion (HPT) bildet mit den Metallen der 8. Nebengruppe des Periodensystems intensiv gefärbte Chelatkomplexe. Führt man die Reaktion in wäßriger Phase bei pH 7 aus, so werden alle Elemente der Gruppe erfaßt und als schwerlösliche Neutralkomplexe gefällt. Diese lassen sich mit Chloroform extrahieren und dünnschichtchromatographisch trennen. Die Nachweisgrenze der Metalle liegt zwischen 3 und 40 ng (Fluorescenzlöschung bei 254 nm). Spektralphotometrische Auswertung der Chromatogramme läßt eine Erniedrigung der Nachweisgrenze um eine Zehnerpotenz erwarten.
    Notizen: Summary 1-Hydroxy-2-pyridinethione (HPT) forms highly coloured chelate complexes with the metals of the 8th sub-group. If the reaction is carried out in aqueous solution at pH 7, all elements of the group precipitate as insoluble neutral complexes. They can be extracted with CHCl3 and separated by thin-layer chromatography. The detection limit is between 3 and 40 ng (fluorescence quenching at 254 nm). Spectrophotometric determination of the chromatograms lowers the detection limit by one power of ten.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00483595
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  • 39
    Digitale Medien
    Digitale Medien
    Selective and sensitive spectrophotometric determination of Vanadium(V) with p-Hydroxybenzaldehyde and Hydroxyamidine (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 297 (1979), S. 159-160 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Vanadium(V) mit p-Hydroxybenzaldehyd und Hydroxyamidin ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00483599
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  • 40
    Digitale Medien
    Digitale Medien
    Rapid T.L.C. separation of some closely related potential antidiabetic guanylpyrazole nitrates (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 298 (1979), S. 44-44 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Trenn. von Guanylpyrazolnitraten ; Chromatographie, Dünnschicht
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00470050
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  • 41
    Digitale Medien
    Digitale Medien
    Isonitrosodibenzoylmethane as an extractant and colorimetric reagent for palladium and ruthenium (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 298 (1979), S. 158-158 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Palladium, Ruthenium ; Spektralphotometrie ; Isonitrosodibenzoylmethan
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00521661
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  • 42
    Digitale Medien
    Digitale Medien
    Spectrophotometric determination of ruthenium(III) with 3-hydroxy-3-(p-dimethyl-aminophenyl)1-phenyltriazene (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 298 (1979), S. 160-160 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Ruthenium(III) mit 3-Hydroxy-3-(p-dimethylaminophenyl)-1-phenyltriazen ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00521664
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  • 43
    Digitale Medien
    Digitale Medien
    Synaptology of the central nervous system of the freshwater snail Lymnaea stagnalis (L.), with particular reference to neurosecretion (1979)
    Springer
    Cell & tissue research 198 (1979), S. 217-235 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Synaptic contacts ; Neurosecretion ; Lymnaea stagnalis ; Tilting stage electron microscopy ; Serial section reconstruction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary In the central nervous system (CNS) of the freshwater snail Lymnaea stagnalis 3 types of interneuronal contacts can be distinguished electron-microscopically, viz. true synapses, “synapse-like structures” (SLS), and “spinules”. Use of the electron microscope specimen tilting stage reveals numerous true synapses. Both “terminal” and “en passant” contacts occur on neurones and on glial cells. Furthermore “bigeminal” synapses are present. Complex (combined) convergent and divergent synaptic arrangements are found. On the basis of the morphology of presynaptic vesicles 7 types of true synapses can be discerned. Histochemical data on the contents of the vesicles are lacking. However, vesicle morphology suggests that type IV is aminergic and type VII cholinergic. Terminal and en passant SLS may penetrate deeply into neuronal somata and large axons, and into glial cells. A cluster of synaptic vesicles is present in the presynapse-like element. Spinules (spine-coated “evagination-invagination” specializations of the plasma membranes of 2 adjacent neuronal elements) are observed between somata, between axons, and between soma and axon. The neurosecretory Light Green Cells (LGC) and Caudo-Dorsal Cells (CDC) receive complex synaptic input. Type V true synapses, 2 types of SLS, and spinules contact the LGC. The complex morphology of the relationship between type A SLS and LGC, studied in serial sections, reveals that adjacent glial cells are also contacted by type A SLS. Type II true synapses, 3 types of SLS, and spinules are identified on the CDC. The validity of the methods of identification and classification of interneuronal contacts in the CNS of L. stagnalis, as well as the role of these contacts in the regulation of the activity of “ordinary” neurones, neurosecretory cells, and glial cells is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00232006
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  • 44
    Digitale Medien
    Digitale Medien
    The hypothalamo-hypophysial system in the ground squirrel, Citellus erythrogenys Brandt (1979)
    Springer
    Cell & tissue research 198 (1979), S. 539-556 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Neurosecretion ; Ground squirrel (Citellus erythrogenys Brandt) ; Seasonal changes ; Hibernation ; Quantitative analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Monthly observations of the “Gomori-positive” hypothalamo-hypophysial neurosecretory system (HHNS) of the ground squirrel, Citellus erythrogenys Brandt, were carried out light microscopically using several quantitative methods. From the beginning of hibernation, formation of neurosecretory material (NSM) in the neurosecretory cells (NSC) progressively decreases and release of neurohormones from the HHNS is almost fully inhibited. A maximal accumulation of NSM in the perikarya of the NSC and in the posterior pituitary (PP) is found in December. By this time the volume of the cell nuclei and nucleoli is at a minimum. Signs of activation of the HHNS appear and become more conspicuous as the time of arousal from torpor approaches. The amount of NSM in the NSC and the PP decreases simultaneously with the increase in volume of the NSC. Hyperemia and activation of glial elements is visible throughout the HHNS. The morphological signs of activation reach their peak in March. After reproduction is completed (April to beginning of May), the NSC and the PP are almost devoid of NSM. Beginning with June and during the summer and autumn months a progressive accumulation of NSM in the NSC and the PP parallels gradual diminution in the volume of the NSC structures and the glial cells. Mechanisms and effector pathways by which the HHNS influences seasonal adaptation of the organism and reproduction are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00234197
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  • 45
    Digitale Medien
    Digitale Medien
    Electron microscopic study of the giant cells in the olfactory bulb of labyrinth fish (Belontiidae, Perciformes) (1979)
    Springer
    Cell & tissue research 199 (1979), S. 509-517 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Olfactory bulb ; Giant cells ; Neurosecretion ; Electron microscopy ; Labyrinth fish
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The giant cells in the olfactory bulb of labyrinth fish, most likely belonging to the nervus terminalis, show ultrastructural features of active synthesis of secretory material. Dense core vesicles (70–100 nm in diameter), found in the perikaryon as well as in the axon, are the possible storage sites of the secretory substance. Its chemical nature is unknown. In some of these vesicles acid phosphatase is demonstrable. Large membrane-bound bodies (up to 2000 nm in diameter), either containing an electron dense matrix or debris of cytoplasmic organelles, are also acid phosphatase-positive, suggesting their lysosomal nature. Some other ultrastructural characteristics of these cells are also described.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00236086
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  • 46
    Digitale Medien
    Digitale Medien
    Diphenylamin im DC-Fließmittel als universelles Detektionsmittel (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 296 (1979), S. 45-45 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Chromatographie, Dünnschicht ; Diphenylamin als Detektionsmittel
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481170
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  • 47
    Digitale Medien
    Digitale Medien
    Note on the determination of traces of o-dichlorobenzene in aqueous solutions by UV-spectrophotometry (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 296 (1979), S. 45-45 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von o-Dichlorbenzol ; Spektralphotometrie ; UV
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481171
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  • 48
    Digitale Medien
    Digitale Medien
    Spectrophotometric determination of p-methylaminophenol sulphate (metol) (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 296 (1979), S. 46-46 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von p-Methylaminophenolsulfat, Metol ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481172
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  • 49
    Digitale Medien
    Digitale Medien
    Vollautomatische rechnergesteuerte Auswertung von Dünnschicht-Chromatogrammen (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 296 (1979), S. 369-373 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Chromatographie, Dünnschicht ; vollautomat. Auswertung von Chromatogrammen
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Es werden vollautomatische DC-Photometer beschrieben, bei denen ein Rechner die optimale Positionierung der DC-Flecke im Meßspalt steuert. Es lassen sich nicht nur die normalen Meßkurven, sondern auch die gemäß der Kubelka-Munk-Funktion transformierten Kurven für die Auswertung heranziehen. Infolge der Steuerung des Wellenlängenantriebes lassen sich auch Zweiwellenlängentechniken simulieren. Für die Auswertung eignet sich auch die 1. Ableitung der Meßkurve. Die Genauigkeit und Reproduzierbarkeit wird gesondert nach Auftragefehler, Meßfehler, Positionierfehler und Fehler der Chromatographie ausgewiesen.
    Notizen: Summary Automated photometers for evaluating TLC plates by an optimized positioning of the spots in respect to the centre of the light beam are described. The evaluation can be performed by using the original measuring curve or a transformed one in respect to the Kubelka-Munk function. Two-wavelength techniques can be simulated, for the monochromator is controlled by the computer. This method has an advantage in measuring not well separated spots. In this case also an evaluation of the first derivative is often successful. The accuracy and reproducibility is given in respect to the different sources of errors: spotting, measurement, positioning and chromatography.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00479975
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  • 50
    Digitale Medien
    Digitale Medien
    Zur spektralphotometrischen Bestimmung von Ligninsulfonsäure und Huminsäure in Wässern (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 296 (1979), S. 406-407 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Ligninsulfonsäure, Huminsäure in Wasser ; Spektralphotometrie ; UV
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00479985
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  • 51
    Digitale Medien
    Digitale Medien
    Rapid determination of boron traces in silicate materials (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 296 (1979), S. 383-385 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Bor in Silicaten ; Spektralphotometrie ; Pyrohydrolyse, Carminsäure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Summary This simple method for the determination of boron takes a total time of 20 min. Samples are mixed with CaF2 suprapur in the ratio 3∶1 and pyrohydrolized in a Leco induction furnace for 15 min under steam of H2O. The BF3 liberated is collected in a NaOH-Na2CO3 solution (10 g NaOH +1 g Na2CO3 per liter). This solution is filled up to 200 ml with twice distilled water; 2 ml of this solution is mixed with conc. sulphuric acid and carminic acid solution and filled up to 50 ml. The absorption is measured by a Zeiss Elko II photometer with filter S 59. Analyses of four internations reference samples show excellent precision with a relative standard deviation of less than 5% (e.g. for a boron content of 2.1 ppm in granite G-2).
    Notizen: Zusammenfassung Die Borbestimmung mit dieser schnellen und einfachen Methode benötigt ca. 20 min. Die Proben werden mit CaF2 Suprapur im Verhältnis 3∶1 vermischt und in einem Leco-Induktionsofen 15 min unter Einleitung von Wasserdampf pyrohydrolysiert. Das entstandene BF3 wird in einer NaOH-Na2CO3-Lösung(10 g NaOH+1 gNa2CO3pro Liter) aufgefangen. Diese Lösung wird mit zweifach destilliertem Wasser auf 200 ml aufgefüllt; 2 ml dieser Lösung werden mit konz. Schwefelsäure und Carminsäure-Lösung versetzt und auf 50 ml aufgefüllt, bevor ihre Absorption mit einem Zeiss — Elko II — Photometer mit Filter S 59 gemessen wird. Analysen von 4 internationalen Referenzproben zeigen eine hohe Präzision mit einer relativen Standardabweichung von weniger als 5% (z. B. für einen Gehalt von 2,1 ppm Bor im Granit G-2 des USGS).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00479979
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  • 52
    Digitale Medien
    Digitale Medien
    Spectrophotometric determination of N-p-tolylbenzohydroxamic acid (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 296 (1979), S. 407-408 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von N-p-Tolylbenzohydroxamsäure ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00479986
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  • 53
    Digitale Medien
    Digitale Medien
    Spectrophotometric determination of Mercury(II) with 3-methyl-5-pyrazolone-4-dithiocarboxylic acid (MPDTH) (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 296 (1979), S. 414-415 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Quecksilber(II) mit 3-Methyl-5-pyrazolon-4-dithiocarbonsäure ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00479994
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  • 54
    Digitale Medien
    Digitale Medien
    Ultrastructural development of the neurohemal organ joined to the ecdysial gland after imaginal moulting in the male isopod Sphaeroma serratum fab. (Crustacea Flabellifera) (1979)
    Springer
    Cell & tissue research 203 (1979), S. 403-414 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Neurohemal organ ; Neurosecretion ; Moulting gland ; Ultrastructure ; Crustaceans
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Chez Sphaeroma serratum, la mue de puberté est suivie d'une dégénérescence de l'organe Y (glands de mue). Le plexus nerveux céphalique latéral, organe neurohémal accolé à cette glande a été l'objet de la présente étude ultrastructurale. Cet organe représente un centre de stockage de neurosécrétions qui proviennent d'une part, de deux cellules autochtones (cellules plexales) situées au sein même de ce plexus, d'autre part, de cellules neurosécrétrices situées dans le “ganglion mandibulaire” (cellules de type A). Chez les individus pubères, les cellules plexales et les cellules A du ganglion sous-oesophagien synthétisent des granules de neurosécrétion dont la taille est respectivement 1550±50Å et 1570±40Å. Il a été reconnu au sein du plexus 5 catégories de terminaisons dont les granules proviendraient pour deux d'entre elles des cellules plexales et des cellules A du “ganglion mandibulaire”. Chez les animaux pubères on observe un arrêt de la synthèse des granules de neurosécrétion au sein des cellules plexales et des cellules A du “ganglion mandibulaire”. Simultanément on enregistre dans le plexus la raréfaction puis la disparition des divers types de granules. Ce processus atteint en premier les terminaisons correspondant aux cellules plexales et aux cellules A du “ganglion mandibulaire”. La dégénérescence de la glande de mue chez les mâles pourrait être en relation avec l'arrêt de synthèse de ces cellules.
    Notizen: Summary The present ultrastructural study deals with the lateral cephalic nerve plexus of Sphaeroma serratum, a neurohemal organ joined to the Y organ (ecdysial gland). This plexus acts as a storage centre for neurosecretory products from two sources: the two autochtonous cells (plexus cells) within the plexus itself, and the neurosecretory cells in various parts of the central nervous system, particulary the “mandibular ganglion” (A-cells). In prepuberal animals, plexus cells and subesophageal A-cells produce neurosecretory granules of two types measuring 1550±50Å and 1570±40Å respectively. Five categories of axon terminals were distinguished in the plexus. The granules found in two of these terminal types are believed to come from the plexus cells and from the “mandibular ganglion” A-cells. Cessation of production of neurosecretory granules in these A cells and plexus cells was observed in puberal animals, in the plexus with concomitant depletion and disappearance of different granule categories. The first axon terminals affected by this process are the two categories containing granules originating in the plexus and “mandibular ganglion” A-cells. Degeneration of the ecdysial gland in male Sphaeroma serratum might be connected with the cessation of granule formation in these two types of cell.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00233270
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  • 55
    Digitale Medien
    Digitale Medien
    Immunocytochemical identification of hyperglycemic hormone-producing cells in the eyestalk of Carcinus maenas (1979)
    Springer
    Cell & tissue research 204 (1979), S. 379-385 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Neurosecretion ; Immunofluorescence ; Crustacea ; X-organ ; Hyperglycemic Hormone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Antiserum raised in rabbits against extracts of sinus glands from Carcinus and shown by several criteria to contain antibodies directed against the neurosecretory hyperglycemic hormone was used to locate the hormone-producing perikarya in the optic ganglia. By means of the double antibody fluorescence technique, selective staining of the large neurosecretory perikarya of the medulla terminalis ganglionic X-organ (MTGXO) and their axons is obtained. The axon endings of the sinus gland are also stained. None of the other groups of neurosecretory cells in the eyestalk shows fluorescence. Preabsorption of the antiserum with pure hyperglycemic hormone abolishes the fluorescence.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00233650
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  • 56
    Digitale Medien
    Digitale Medien
    Ultrastructure of the corpus cardiacum and corpus allatum of the house cricket Acheta domesticus (1979)
    Springer
    Cell & tissue research 198 (1979), S. 201-208 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Neurosecretion ; Corpus cardiacum ; Corpus allatum ; Acheta domesticus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The ultrastructure of the corpus cardiacum (CC) and corpus allatum (CA) of the house cricket, Acheta domesticus, is described. Axon profiles within the CC contain neurosecretory granules 160–350 nm in diameter which are indistinguishable from those found in type I neurosecretory cells of the pars intercerebralis and in the nervus corporis cardiaci I. The CC itself contains two cell types: intrinsic neurosecretory cells and glial cells. Intrinsic NSC cytoplasm contains Golgi bodies and electron dense neurosecretory granules 160–350 nm in diameter. Synaptoid configurations with 20–50 nm diameter electron lucent vesicles were observed within axon profiles of the CC. The structure of the CA is relatively uniform with one cell type predominating. Typical CA cells possess large nucleoli, active Golgi complexes, numerous mitochondria, and occassional microtubules. Groups of dark staining cells scattered throughout the CA of some animals were interpreted as evidence of cellular death.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00232004
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  • 57
    Digitale Medien
    Digitale Medien
    The neurosecretory hypothalamo-hindbrain pathway and its possible significance for the regulation of blood pressure and the milk-ejection reflex (1979)
    Springer
    Cell & tissue research 196 (1979), S. 321-336 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Neurosecretion ; Hypothalamo-hindbrain pathway ; Rat ; Blood pressure ; Milk ejection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary 1. In lactating rats and in rats deprived of water, the amount of neurosecretory material in the fibres of the neurosecretory hypothalamohindbrain pathway exceeds that in untreated control animals. Under these experimental conditions the pathway and its target regions can be well analysed by means of fluorescence and electron microscopic methods. 2. The axons belonging to the hypothalamo-hindbrain pathway originate from perikarya located in the caudal portion of the nucleus paraventricularis and also from a small group of perikarya in the caudo-lateral hypothalamus. On the way to the hindbrain the neurosecretory fibres join other fibre bundles of the mid- and hindbrain. 3. In the hindbrain most of the neurosecretory fibres terminate in the area of the nucleus tractus solitarii and in the area of the dorsal column nuclei. The axon terminals form synapses with other neurones. 4. Using cytochemical methods at the ultrastructural level (Naumann and Sterba, 1976), the authors were able to prove that the vesicles in the exohypothalamic fibres and in their synaptic terminals contain the same sort of material as the neurophysin vesicles in the posterior lobe of the hypophysis. 5. The most distinct increase in neurophysin was observed in lactating females which were separated from their sucklings after a normal lactation period of 15 days and killed four days thereafter, and in rats deprived of water for different time periods. 6. The relationship of the neurosecretory hypothalamo-hindbrain pathway to the nucleus tractus solitarii and to the dorsal column nuclei suggests that, functionally, there may be a correlation between the system of blood-pressure control and the milk ejection reflex.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00240105
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  • 58
    Digitale Medien
    Digitale Medien
    Dünnschicht-chromatographische Trennung und Detektion von 14 1,4- bzw. 1,5-Benzodiazepin-Handelspräparaten und 17 Hauptmetaboliten (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 135-139 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Trenn. von Benzodiazepinen ; Chromatographie, Dünnschicht ; Metaboliten
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die DC-Trennung von 14 1,4- bzw. 1,5-Benzodiazepinen und 17 Hauptmetaboliten sowie die Detektion mit Bratton-Marshall-, Dragendorff- und Jodoplateat-Reagens werden beschrieben. Rf-Werte sowie die Reaktionen mit den Reagentien sind tabellarisch zusammengestellt und Biotransformationsschemata angegeben.
    Notizen: Summary Experimental details for the separation are described and data are compiled for Rf-values and reactions with Bratton-Marshall, Dragendorff and iodoplateate-reagents. Biotransformation schemes for the individual benzodiazepines are presented.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00523935
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  • 59
    Digitale Medien
    Digitale Medien
    Photometrische Bestimmung von Aminen mittels 5-Isothiocyanato-1,3-dioxo-2-p-tolyl-2,3-dihydro-1H-benz[de]isochinolin (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 286-286 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Aminen mit Isothiocyanatodioxotolyldihydrobenzisochinolin ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481655
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  • 60
    Digitale Medien
    Digitale Medien
    Spektralphotometrische Bestimmung von Eisen(III) und Chrom(VI) mit Helasolviolett 4R (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 285-285 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Eisen(III), Chrom(VI) mit Helasolviolett 4R ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481653
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  • 61
    Digitale Medien
    Digitale Medien
    Dünnschicht-chromatographischer Nachweis von IOXYNIL in biologischem Material (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 288-288 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Nachw. von Ioxynil in Biolog. Material ; Chromatographie, Dünnschicht
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481657
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  • 62
    Digitale Medien
    Digitale Medien
    Komplexbildung und photometrische Bestimmung von Wolfram(VI) mit Thioglykolsäure und verwandten Chelatbildnern (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 119-121 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Wolfram(VI) mit Thioglykolsäure ; Spektralphotometrie ; Chelatbildung, Carbonsäuren
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung W(VI) bildet mit Thioglykolsäure und Glykolsäure mäßig stabile Fünfringchelate der Zusammensetzung WR2, mit Glycin ein sehr schwaches WR. Chelate mit den Sechsringbildnern 3-Mercaptopropionsäure und o-Mercaptobenzoesäure sind nicht nachweisbar. Das Thioglykolsäurechelat kristallisiert aus Methanol als gelbes Na-Salz WO2(SCH2COONa)2·2CH3OH und ist mit Di-phenylguanidin als Ionenpaar in Butanol extrahierbar. Die photometrische Wolframbestimmung mit Thioglykolsäure in wäßriger Lösung erreicht eine Bestimmungsgrenze von $$\underline c $$ = 0,92 ppm W (P=99,9%;M=2) und eine Standardabweichung vons=0,24 ppm W (f=21).
    Notizen: Summary W(VI) forms moderately stable, five-membered ring chelates of the composition WR2 with thioglycolic and glycolic acid, and a very weak WR with glycine. Chelation with the six-ring forming 3-mercaptopropionic acid and o-mercaptobenzoic acid could not be detected. The chelate with thioglycolic acid crystallizes from methanol as the yellow sodium salt WO2(SCH2COONa)2·2CH3OH and can be extracted into butanol as an ion pair with diphenylguanidine. The photometric determination of tungsten with thioglycolic acid has a determination limit of $$\underline c $$ = 0.92 ppm W (P=99.9%;M=2) and a standard deviations=0.24 ppmW (f=21).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01171498
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  • 63
    Digitale Medien
    Digitale Medien
    Photometry in a continuous flow system (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 122-124 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Sulfat in Umweltmaterial ; Wasser ; Spektralphotometrie ; Durchflußsystem
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Summary Sulphate in various environmental samples was determined by measuring the optical absorbance upon reaction with the barium(II) dimethylsulphonazo(III) complex. The measurement took place in a flow-through system. Interferences from phosphate, metal ions and others were eliminated. The results of a turbidimetric measurement, a spectrophotometric measurement with thorin, an automatic titration and the proposed method are compared. The latter allows the determination of sulphate in the range of 1.4–60 μmol·l−1. The standard deviation is 0.3–0.6 μmol·l−1, depending on the type of sample (water) analysed. A determination takes 1.5min.
    Notizen: Zusammenfassung Sulfat wurde in verschiedenen Umweltproben durch Messung der Extinktion nach Reaktion mit dem Barium(II)-dimethylsulfonazo(III)-komplex im Durchflußsystem bestimmt. Störungen von Phosphat, Metallionen, u.a. wurden beseitigt. Die Ergebnisse einer turbidimetrischen, einer photometrischen, einer automatischen Titration und der vorgeschlagenen Methode werden verglichen. Die Methode ermöglicht die Sulfatbestimmung im Bereich von 1,4–60 μmol·l−1. Die Standardabweichung beträgt 0,3–0,6 μmol· l−1 je nach Typ des Probematerials (Wasser). Eine Bestimmung erfordert 1,5min.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01171499
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  • 64
    Digitale Medien
    Digitale Medien
    Alcohol separation by thin-layer chromatography. II (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 263-265 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Trenn. von Alkoholen ; Chromatographie, Dünnschicht ; C1-C20, 6 Trennsysteme, Dinitrobenzoate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Summary Thin-layer chromatography on rice starch, maize starch, cellulose and talc makes possible the separation of the homologous series of 3,5-dinitrobenzoates of aliphatic alcohols C1 to C20. Six different solvent systems have been employed. Dependence of R f-values on the number of C-atoms on various supports is discussed.
    Notizen: Zusammenfassung Mit Hilfe der Dünnschicht-Chromatographie auf Reisstärke, Maisstärke, Cellulose und Talk wurde die homologe Reihe der 3,5-Dinitrobenzoate von aliphatischen Alkoholen C1 bis C20 getrennt. Sechs verschiedene Fließmittel wurden benutzt. Die Abhängigkeit der R f-Werte von der Zahl der C-Atome auf verschiedene Schichten wird diskutiert.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481489
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  • 65
    Digitale Medien
    Digitale Medien
    Bestimmung von Blei in Abwasser und Staub (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 271-271 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Blei in Wasser, Abwasser, Staub ; Spektralphotometrie ; Dithizon
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481494
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  • 66
    Digitale Medien
    Digitale Medien
    Rapid T.L.C. separation of some closely related potential antineoplastic arylazopyrazoles (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 272-272 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Trenn. von Arylazopyraolen ; Chromatographie, Dünnschicht
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481495
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  • 67
    Digitale Medien
    Digitale Medien
    Rapid spectrophotometric determination of platinum(IV) with chlorpromazine hydrochloride (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 413-413 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Platin(IV) mit Chlorpromazin ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00539718
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  • 68
    Digitale Medien
    Digitale Medien
    A new conception of Bouguer-Lambert-Beer's law (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 297 (1979), S. 419-419 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Spektralphotometrie ; Bouguer-Lambert-Beersches Gesetz, neues Konzept
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00480903
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  • 69
    Digitale Medien
    Digitale Medien
    Rapid spectrophotometric determination of phenothiazines with silicotungstic acid (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 298 (1979), S. 160-160 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Phenothiazinen ; Spektralphotometrie ; Silicowolframsäure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00521665
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  • 70
    Digitale Medien
    Digitale Medien
    Trennung und Identifizierung von 12 antimikrobiellen Verbindungen mittels Dünnschicht-Chromatographie (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 36-41 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Trenn. von Antimikrobiellen Verbindungen ; Chromatographie, Dünnschicht
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die Trennung und Identifizierung von halogenierten, vorwiegend aliphatischen antimikrobiellen Verbindungen, von Formaldehyd abgebenden Substanzen und von Sulfonsäure-Derivaten auf dünnschicht-chromatographischem Wege wird beschrieben. Die Trennung erfolgt auf einer Kieselgel-Cellulose-Mischschicht mit Äthylacetat/Methanol/10% Ammoniak (65+30+5) als Laufmittel. Zur Sichtbarmachung und zur Identifizierung sind mehrere Sprühmittel notwendig: äthanolischeMethylgelb-Lösung mit anschließender UV-Bestrahlung, Phenylhydrazinsulfonat und Natronlauge sowie Hydroxylamin/Eisen(III)-chlorid und Nitroprussidnatrium-Kaliumhexacyanoferrat (III) u. a. Anhand der verschiedenen Rf-Werte und der Anfärbungen lassen sich die antimikrobiellen Verbindungen rasch und einfach identifizieren.
    Notizen: Summary The analysis of halogenated, mainly aliphatic compounds, of formaldehyde donors and of derivatives of sulphonic acid is described. The separation is carried out on plates coated with a mixed layer of silica gel and cellulose and a solvent mixture of ethylacetate/methanol/10% ammonia (65+30+5), whereas for the detection and identification several spray reagents have to be used: ethanolic solution of Methyl Yellow with subsequent UV irradiation, phenylhydrazine-4-sulphonic acid and sodium hydroxide, hydroxylamine/iron(III) chloride, sodium nitroprusside/potassium hexacyanoferrate(III) and others. The Rf-values and the colourations of the spots allow to identify the examined compounds rapidly and without further chemical procedures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00694659
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  • 71
    Digitale Medien
    Digitale Medien
    Spectrophotometric determination of salicylaldehyde using concentrated sulphuric acid (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 43-44 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Salicylaldehyd ; Spektralphotometrie ; konz. Schwefelsäure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00694662
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  • 72
    Digitale Medien
    Digitale Medien
    Spectrophotometric determination of osmium with N-Benzoyl-o-tolylhydroxylamine (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 46-46 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Osmium mit N-Benzoyl-o-tolylhydroxylamin ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00694664
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  • 73
    Digitale Medien
    Digitale Medien
    TLC separation of some inorganic ions on DCTA impregnated thin-layer plates (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 42-42 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Trenn. von anorg. Ionen ; Chromatographie, Dünnschicht ; DCTA-imprägniert
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00694660
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  • 74
    Digitale Medien
    Digitale Medien
    Identification of some closely related potential antidiabetic 4-arylhydrazono-N′-benzylsulphonyl-3-methyl-2-pyrazoline-5-ones by TLC (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 414-414 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Identifizierung von Arylhydrazin-benzylsulfonylmethylpyrazolinonen ; Chromatographie, Dünnschicht
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00468541
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  • 75
    Digitale Medien
    Digitale Medien
    Photometrische Bestimmung von Rinderserumalbumin mittels 5-Isothiocyanato-1,3-dioxo-2-p-tolyl-2,3-dihydro-1H-benz[de]isochinolin (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 415-416 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Albumin in Serum ; Spektralphotometrie ; Isothiocyanatodioxo-tolyldihydro-benzisochinolin, Rinderserum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00468543
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  • 76
    Digitale Medien
    Digitale Medien
    Extractive spectrophotometric determination of ruthenium employing 2-methyl-1,4-naphthoquinone monoxime as a reagent (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 299 (1979), S. 128-128 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Ruthenium mit 2-Methyl-1,4-naphtochinon-monoxim ; Spektralphotometrie ; Extraktion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00518425
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  • 77
    Digitale Medien
    Digitale Medien
    Separation and identification of closely related sulpha drugs by TLC on silica gel — calcium oxalate impregnated plates (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 299 (1979), S. 207-207 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Analyse von Sulfonamiden ; Chromatographie, Dünnschicht
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00581378
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  • 78
    Digitale Medien
    Digitale Medien
    Extractive-spectrophotometric determination of palladium(II) and ruthenium(III) with isonitrosobenzoylacetone (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 412-413 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Palladium(II), Ruthenium(III) mit Isonitrosobenzoylacetone ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00539717
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  • 79
    Digitale Medien
    Digitale Medien
    Hochselektive spektralphotometrische Spurenbestimmung von Uran(VI) mit Arsenazo III nach Extraktionstrennung (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 297 (1979), S. 384-387 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Uran ; Spektralphotometrie ; Spuren, Extraktion mit Triphenylarsinoxid in Chloroform
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Es wurde eine einfache, vielseitig anwendbare spektralphotometrische Uranbestimmung für U6+-Mengen bis in den ng-Bereich ausgearbeitet, bei der über 60 Kationen und etwa 20 Anionen in weiten Grenzen nicht stören. Das mit Triphenylarsinoxid in CHCl3 aus der zu untersuchenden Lösung extrahierte Uran wird mit oxalsäurehaltiger 5,5 M HClO4 zurückextrahiert und in den Arsenazo III-Komplex überführt. Die mit diesem Schritt verbundene Aufkonzentrierung erlaubt noch bis zu 0,01 μg Uran in 200 ml Ausgangslösung spektralphotometrisch bei 655 nm zu bestimmen. Im günstigsten Arbeitsbereich beträgt die relative Standardabweichung ±1%. 4 Probelösungen können in 1 h analysiert werden.
    Notizen: Summary A simple and versatile spectrophotometric method for the determination of uranium down to the μg range was worked out. About 60 cations and 20 anions were found not to cause interferences in a wide concentration range. U6+ is extracted with triphenylarsine oxide in chloroform, back-extracted with 5.5 M perchloric acid containing oxalic acid and converted to the arsenazo III-complex. The concentration step involved allows the spectrophotometric determination of 0.01 μg of uranium in 200 ml of original solution at 655 nm. A standard deviation of ±1 % can be achieved and it is possible to analyse about 4 solutions per hour.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00480894
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  • 80
    Digitale Medien
    Digitale Medien
    Batchwise photometric determination of sulphate in water samples (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 298 (1979), S. 156-157 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Sulfat in Wasser ; Spektralphotometrie ; Ionenaustausch, Dimethylsulfonazo(III)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00521659
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  • 81
    Digitale Medien
    Digitale Medien
    Fluorone — Reagentien für die photometrische Analyse (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 298 (1979), S. 150-154 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Kupfer mit Fluoronen ; Spektralphotometrie ; Übersicht über die Fluorone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Fluorone, Verbindungen des 2,3,7-Trihydroxyisoxanthenons-(6), eignen sich als empfindliche Reagentien für die spektralphotometrische Analyse zahlreicher Metallionen im sichtbaren Teil des Spektrums. Neben einigen grundsätzlichen Anmerkungen zur Herstellung, zu den Eigenschaften und Reaktionen der Fluorone mit Metallionen wird die Verwendung des Cyclohexylfluorons (CHF) für die photometrische Bestimmung von Cu(II)-Ion beschrieben; hierbei ergibt sich ein molarer Extinktionskoeffizient von 191000 l/Mol · cm und eine Standardabweichung von ±0,2 ng/ml. Der Anwendungsbereich liegt bei 6–60 ng Cu/ml. Bi, Fe(II/III) und Sb müssen zuvor abgetrennt werden.
    Notizen: Summary Fluorones, derivates of 2,3,7-trihydroxyisoxanthenone-(6), are sensitive reagents for the spectrophotometric determination of many metal ions in aqueous solution. Besides some principal remarks on the synthesis, properties and reactions of fluorones, the application of cyclohexylfluorone for the determination of Cu(II) ion is described in detail. This method is applicable in the concentration range 6–60 ng of Cu/ml. The molar absorptivity is 1910001/Mol · cm and the standard deviation is ±0.2 ng/ml. Bi, Fe(II, III) and Sb have to be separated prior to the determination.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00521657
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  • 82
    Digitale Medien
    Digitale Medien
    Effects of measuring system parameters on the frequency dependence of strain-related potentials in bone (1979)
    Springer
    Medical & biological engineering & computing 17 (1979), S. 471-475 
    Details
    ISSN: 1741-0444
    Schlagwort(e): Bone ; Strain
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Specimens of dry human cortical bone of a disc form were subjected to sinusoidal loading under controlled conditions. The results show a nonlinear increase of the measured peak potential with frequency which reaches a limiting value at about 200 Hz. The analysis, which is based on the circuit representation proposed previously by Shamos, indicates that such a behaviour can be attributed to the measuring circuit parameters. It was found that some relevant results can be interpreted qualitatively by similar analysis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02447060
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  • 83
    Digitale Medien
    Digitale Medien
    Scanning electron microscope study of separated calcospherites from the matrices of different mineralizing systems (1978)
    Springer
    Calcified tissue international 26 (1978), S. 47-49 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Matrix vesicles ; Calcospherites ; Mineralization ; Bone ; Dentin ; Cartilage ; SEM
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Mineral particle cluster, corresponding to calcospherites or matrix vesicle-initiated clusters in calcifying cartilage and dentin and to collagen bundle-related mineralization in lamellar bone, have been isolated from NaOCl solutions used to dissolve the organic matrix in preparation of anorganic mineralizing fronts for scanning electron microscopy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02013233
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  • 84
    Digitale Medien
    Digitale Medien
    Mechanism of osteoclastic bone resorption: A new hypothesis (1978)
    Springer
    Calcified tissue international 26 (1978), S. 81-84 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Osteoclasts ; Bone ; Resorption
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Osteoclastic bone resorption involves the solubilization of the mineral salts and the degradation of noncollagen bone matrix and collagen fibrils. As no recognizable collagen fibrils have ever been reported within cytoplasmic vacuoles in osteoclasts, it is generally assumed that the collagen fibrils are digested extracellularly in the resorption zone. The extent to which lysis occurs extracellularly and whether or not the osteoclasts phagocytose the degradation products remain to be established. In the present communication, a hypothesis is presented suggesting the possibility that osteoclastic resorption of bone involves the participation of two different cell types. According to this hypothesis, osteoclastic bone resorption is initiated by osteoclasts that demineralize areas of bone and degrade noncollagen bone matrix. After the osteoclasts have moved away or become partially detached from the demineralized site, the exposed collagen fibrils are phagocytosed by mononuclear, fibroblast-like or monocyte-derived cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02013238
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  • 85
    Digitale Medien
    Digitale Medien
    Plasma disappearance of rabbit α2 HS-glycoprotein and its uptake by bone tissue (1978)
    Springer
    Calcified tissue international 26 (1978), S. 155-161 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Plasma protein ; Glycoprotein ; Bone ; Glucosamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Plasmaα 2HS-glycoprotein is specifically accumulated in calcified tissues. In the present studies this glycoprotein was isolated from plasma and after iodination with iodine-125 was injected intravenously into young rabbits. The tissue distribution and plasma disappearance rate of this radioactively labeled material were determined. Of the various tissues studied, bone showed the greatest retention of labeled glycoprotein expressed as percentage of the injected dose per gram tissue relative to the plasma content. The rate of loss of iodinatedα 2HS-glycoprotein from plasma was similar to that ofα 2HS-glycoprotein labeled endogenously by using14C-glucosamine or3H-glucosamine. The uptake of exogenously labeled3I-α 2HS-glycoprotein into bone tissue expressed as a percentage of the injected dose was similar to that of endogenously labeled14C-α 2HS-glycoprotein. These results suggest that the125I-labeled material can be used to study further the metabolism ofα 2HS-glycoprotein by bone tissue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02013251
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  • 86
    Digitale Medien
    Digitale Medien
    Effect of mithramycin on boneβ-glucuronidase and resorption (1978)
    Springer
    Calcified tissue international 26 (1978), S. 209-213 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Mithramycin ; Bone ; β-Glucuronidase ; KT medium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Mithramycin suppresses bone resorption. Its effect on the synthesis and release of β-glucuronidase (a referent for lysosomal enzymes) in mouse calvarial explants was studied in an in vitro culture system. A newly described medium (designated as KT medium) was introduced in this specific study. Mithramycin initially inhibited the release of β-glucuronidase into the medium and resulted in an ultimate accumulation of this enzyme in the bone. These results suggest that inhibition of bone resorption by mithramycin may be attributed to interference in release of lysosomal enzymes from bone cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02013260
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  • 87
    Digitale Medien
    Digitale Medien
    Radiogenic free radicals as molecular probes in bone (1978)
    Springer
    Calcified tissue international 25 (1978), S. 37-43 
    Details
    ISSN: 1432-0827
    Schlagwort(e): ESR ; Radiation free radicals ; CO3-Apatites ; Bone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Exposure of bone mineral to X-rays generates free radicals. These are usually very labile, but can be stabilized at liquid nitrogen temperatures for study by electron spin resonance spectroscopy. The free radicals thus detected in the present study included one with resonances arising from an electron excess center and 2 species with electron-deficit centers: a phosphate anion radical and a radical associated with carbonate. Each of these radicals seemed to be located chiefly at the mineral surface and was sensitive to the surface environment. Presence of an organic phase, as in whole bone, modified free radical production in a manner that suggests interference with the formation of electron deficit centers. Comparison with other synthetic minerals suggests that precipitated carbonateapatites are good models for bone mineral.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02010749
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  • 88
    Digitale Medien
    Digitale Medien
    Selective stimulation of net calcium efflux from chick embryo tibiae by parathyroid hormone in vitro (1978)
    Springer
    Calcified tissue international 25 (1978), S. 227-232 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Parathyroid hormone ; Bone ; Calcium ; Chick embryo ; Organ culture
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The purpose of this study was to measure in an in vitro system the movement of Ca and phosphate (Pi) out of bone when treated with parathyroid hormone (PTH). Tibiae from 13-day chick embryos were incubated for up to 8 h in a defined medium containing 1.8 mM Ca. Medium samples were collected every 2 h and were analyzed for Ca, Pi and lactate. Net effluxes from the bones were calculated. When bones were incubated with PTH in the medium (1 U/ml), net Ca efflux was increased 44, 60 and 100% at 4, 6 and 8 h, respectively. At no time was net Pi efflux affected by the hormone. The well known PTH-stimulated lactate production was not seen until 8 h. Lower doses of PTH (0.1 and 0.3 U/ml) were also effective. Comparing PTH (1 U/ml) responsiveness at higher (2.2 mM) and lower (0.9 mM) medium Ca concentrations, showed that with 2.2 mM Ca no increased Ca efflux was seen, while with 0.9 mM Ca significant elevation in medium Ca occurred 2 h sooner than in the experiments using 1.8 mM Ca. In another experiment, varying the medium Pi level from 1 to 2 mM had no effect on the Ca response to PTH. In neither experiment was Pi release affected by PTH. The results of this study have led to the following conclusions: (1) PTH acts on bone to cause an early dose related increase in net Ca efflux; (2) the effect is specific for Ca, since it is not accompanied by an increased Pi efflux, and may be saturated by raising the medium Ca level; and (3) PTH-stimulated Ca efflux in this system is not correlated with, and is probably not a result of increased lactate production.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02010774
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  • 89
    Digitale Medien
    Digitale Medien
    A bone resorbing substance from bovine serum albumin (brA) (1978)
    Springer
    Calcified tissue international 25 (1978), S. 233-240 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Bone resorption ; Albumin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary A fraction (brA), which causes resorption of fetal rat bones in vitro, has been concentrated from bovine serum albumin by anion exchange column chromatography on DEAE Sephadex. This active fraction has also been prepared using DEAE Sephadex A-50 by a batch method with a 0.09M NaCl, 0.1M TRIS buffer, pH 8.35. BrA was 10–30 times more potent than the original albumin. The retained material, which constitutes the bulk of the protein and has less activity than the original albumin, elutes with 0.45M NaCl. Similar treatment of serumα,β or γ globulins does not yield brA. Further enhancement of the bone resorbing activity of brA can be obtained with (NH4)2SO4 fractionation or extraction with CH3OH∶CHCl3. Heating at 55° C for 2 h or at 100° C for 10 min does not affect the activity; overnight incubation with protease destroys the bone resorbing effect. The bone resorbing activity is not removed by dialysis and does not correlate with the protease activity of the fraction. The action of brA is inhibited by 3 mM PO4, 1 μg/ml calcitonin or glucagon, 10−7 M dexamethasone or 0.02 μg/ml actinomycin D. The bone resorbing activity of brA is partially inhibited by 10−7–10−5 M indomethacin. PTH did not elicit bone resorption when added to cultures incubated in chemically defined medium supplemented with 0.1 mg/ml brA. However, brA did not inhibit PTH-induced resorption.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02010775
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  • 90
    Digitale Medien
    Digitale Medien
    Oestrogen binding proteins in bone cell cytosol (1978)
    Springer
    Calcified tissue international 25 (1978), S. 249-254 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Oestrogens ; Oestrogen receptors ; Binding proteins
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Attempts were made to demonstrate the presence of specific oestrogen binding proteins (“receptors”) in bone cells. High speed cytosol preparations of bone were incubated with several concentrations of radioactive oestradiol alone and with radioactive oestradiol in the presence of a specific antioestrogen, Nafoxidine. Separation of bound and free oestradiol was carried out by dextran coated charcoal treatment and by sucrose gradient ultracentrifugation. Several types of bones likely to be oestrogen-sensitive were investigated: human femoral heads, human phalanx, rat and rabbit calvaria, humeri and femora of female rats. In all experiments we were unable to demonstrate the presence of specific oestrogen receptors in bone cell cytosol indicating that the direct effect of oestrogens on bone, if present, is not mediated by specific oestrogen receptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02010778
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  • 91
    Digitale Medien
    Digitale Medien
    Quantitative histology of bone: A computerized method of measuring the total mineral content of bone (1978)
    Springer
    Calcified tissue international 26 (1978), S. 85-89 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Histology ; Microradiography ; Densitometry ; Computer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary A comparatively simple quantitative method for assessing bone morphology has been evolved. Microradiographs of thin sections of mandible have been scanned with a Joyce-Loebl double beam recording microdensitometer with a scanning autodensidater attachment, using a white beam. For each image the optical densities for all the pixels (picture elements) were divided into 10 groups. The limits of the division were fixed by the maximum and minimum densities occurring within the image. A computer generated map was produced which indicated the spatial distribution of the pixels within each group to which an arbitrarily chosen shading was attached. The number of pixels within each group is also shown on the map. The computer map was compared with the photomicrograph and, where necessary, the original section. The fractional area of hard tissue was then readily determined using the numerical values of each group of pixels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02013239
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  • 92
    Digitale Medien
    Digitale Medien
    Surface area of dental enamel, bone, and hydroxyapatite: Chemisorption from solution (1978)
    Springer
    Calcified tissue international 26 (1978), S. 139-142 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Chemisorption ; Surface area ; Hydroxyapatite ; Bone ; Enamel
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The surface areas of three different samples of hydroxyapatite, samples of deproteinized bone, and samples of whole and deproteinized enamel were determined by adsorption of an adduct (the diglycidyl ether of bisphenol A with N-phenylglycine) from methylene chloride solution. In all cases, the surface areas of these samples agree well with those obtained by the BET (N2) method.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02013248
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  • 93
    Digitale Medien
    Digitale Medien
    Effect of sex steroids on bone collagen synthesis in vitro (1978)
    Springer
    Calcified tissue international 25 (1978), S. 105-110 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Progesterone ; 17β estradiol ; Testosterone ; Tissue culture ; Bone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Although sex steroids are known to affect skeletal metabolism, their effects on bone collagen synthesis have not been studied. We have examined the direct effects of progesterone, 17β estradiol, testosterone, 5α dihydrotestosterone and dehydroepiandrosterone on bone collagen and noncollagen protein synthesis in cultures of calvaria obtained from 21-day fetal rats. Bones were incubated for 24 to 168 h and3H-proline was added for the last 2 h of culture. Incorporation of the label into collagenase-digestible protein (CDP)1 and noncollagen protein (NCP) was determined using repurified bacterial collagenase. Progesterone caused a dose dependent inhibition of the labeling of CDP at concentrations of 3×10−7 M to 10−5 M after 96 h of culture. A smaller inhibitory effect was observed on NCP. The inhibitory effect was slow in onset and persisted when bones were incubated for 48 h with progesterone and then transferred to control medium for 48 h. Progesterone also inhibited the incorporation of3H-thymidine and3H-uridine into fetal rat calvaria. After 24 h of culture, 17β estradiol and testosterone had no effects on the labeling of CDP and NCP. After 96 h, 17β estradiol had a small and inconsistent stimulatory effect on the labeling of CDP but testosterone had no effect. Neither hormone altered the inhibitory effects of parathyroid hormone, cortisol and progesterone. Dihydrotestosterone and dehydroepiandrosterone had no effects after 24 h and 96 h of culture. 17β estradiol, testosterone and dihydrotestosterone did not affect the incorporation of3H-uridine or3H-thymidine into fetal rat calvaria. Our studies indicate that progesterone is an inhibitor of bone collagen synthesis and estrogens and androgens are not major regulators of bone formation in vitro.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02010758
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  • 94
    Digitale Medien
    Digitale Medien
    The effect of growth retardation and of osteomalacia on the uptake of albumin by bone (1978)
    Springer
    Calcified tissue international 25 (1978), S. 29-35 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Albumin ; Bone ; Growth retardation ; Osteomalacia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary 125I-labeled rat albumin injected intravenously into rats was taken up by growing bone. Some of this radioactive albumin could be removed from bone by washing with saline, the proportion so removed decreasing from 82.5% at 1 day to 7.4% at 8 days. Both the total radioactivity, and that remaining in bone after saline wash, were reduced when growth was slowed by alteration or restriction of the diet. Although the amount of125I albumin in rachitic bone was reduced, autoradiography showed that radioactivity was present in rachitic osteoid. Immunoprecipitation using anti-rat-albumin serum showed that about half of the radioactivity released from normal bone by EDTA was still attached to albumin. These results suggest that albumin plays some part in the growth of bone.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02010748
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  • 95
    Digitale Medien
    Digitale Medien
    Spectrophotometric determination of vitamin D2 (calciferol) by reaction with HCl and tetrachloroethane (1978)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 293 (1978), S. 416-416 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best von Vitamin D2 ; Spektralphotometrie ; HCl, Tetrachloräthan
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00471467
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  • 96
    Digitale Medien
    Digitale Medien
    Spectrophotometric determination of picric acid with zinc and ammonium chloride (1978)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 293 (1978), S. 416-416 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Pikrinsäure ; Spektralphotometrie ; Zink und Ammoniumchlorid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00471468
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  • 97
    Digitale Medien
    Digitale Medien
    Optimierung der spektralphotometrischen Uran(VI)-Bestimmung mit Arsenazo III in starksauren Lösungen (1978)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 292 (1978), S. 43-44 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Uran(VI) mit Arsenazo III ; Spektralphotometrie ; starksaure Lösung
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481329
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  • 98
    Digitale Medien
    Digitale Medien
    Spektralphotometrische Bestimmung von Thallium(I)- und Dimethylthalliumverbindungen in geringen Konzentrationen (1978)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 292 (1978), S. 46-47 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Thallium(I), Dimethylthalliumverbindungen ; Spektralphotometrie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481332
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  • 99
    Digitale Medien
    Digitale Medien
    Über die analoge on-line-Differentiation höherer Ordnung zur Feinauflösung von UV-Visible-Spektren und anderen elektrischen Meßsignalen (1978)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 292 (1978), S. 233-235 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Spektralphotometrie ; Ableitungen höherer Ordnung, Analogdifferenzierer, Derivativverfahren
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Es wird über eine neu entwickelte Analog-Recheneinheit berichtet, mit der man Ableitungen von Spektren und anderen Meßsignalen erstmalig bis zur 7. Ordnung on-line verwirklichen kann. Wie die Prüfungen ergaben, ist die optimale Auflösung in den meisten Fällen mit der 4. Ableitung erreicht. Dann sind nämlich alle Schultern und Wendepunkte der Kurven in bipolare Signale übergeführt. Eine Aufstellung der wichtigsten bisherigen Anwendungsgebiete wird gegeben.
    Notizen: Summary This report deals with a newly developed analogue computing accessory by which derivations of spectra and other electric signals up to the seventh order were realized on-line. A thorough study of this apparatus showed that in most cases fine-resolving is reached by the fourth derivation. In this case, all shoulders and points of inflections are resolved to bipolar signals. A number of examples for applying derivative spectrophotometry of higher order (DSHO-method) is also given.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00491814
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  • 100
    Digitale Medien
    Digitale Medien
    Quantitative dünnschicht-chromatographische Bestimmung von aromatischen Aminen nach der Remissionsmethode (1978)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 292 (1978), S. 381-384 
    Details
    ISSN: 1618-2650
    Schlagwort(e): Best. von Aminen, aromat. ; Chromatographie, Dünnschicht ; Remissionsmessung
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Es wird eine Methode zur quantitativen Bestimmung von aromatischen Aminen beschrieben. Diese werden dünnschicht-chromatographisch auf Kieselgel 60 F254 Fertigplatten in den Laufmitteln n-Propanol/Methanol/Wasser/Eisessig (65∶15∶15∶20; Vol.) oder n-Butanol/Wasser/Eisessig (66∶17∶17; Vol.) von den Begleitstoffen abgetrennt. Die getrennten Aminflecke werden entweder im Ultraviolett-Bereich oder nach Diazotierung im sichtbaren Bereich mit dem Chromatogramm-Spektralphotometer PMQ II nach der Remissionsmethode gemessen und anhand der auf derselben Platte aufgestellten Eichgerade ausgewertet. Die quantitative Bestimmung wird anhand der beiden Amine 5-Amino-2,4,6-trijod-isophthalsäurebis-(2,3-dihydroxy-propyl-N-methylamid) (I) und 2,4,6-Trijod-3-aminobenzoesäure (II) in Röntgenkontrastmittelpräparaten (RKP) demonstriert. Sowohl im UV- als auch im sichtbaren Bereich, läßt sich in 3000 μg RK-Säure (RKS) noch 0,1 μg freies aromatisches Amin, das sind 0,003%, bezogen auf die eingesetzte Menge RKS, mit einer maximalen relativen Standardabweichung von 4% bestimmen. Diese Methode ist spezifischer und empfindlicher als die der Diazotierung in Lösung.
    Notizen: Summary The aromatic amines are separated from impurities by thin-layer chromatography on silica gel 60 F254 precoated plates in the mobile solvents n-propanol/methanol/water/glacial acetic acid (65∶15∶15∶20; vol.) or n-butanol/water/glacial acetic acid (66∶17∶17; vol.). The separated amine spots are measured by the remission method by means of the TLC densitometer PMQ II, either in the u.v. region or, after diazotization, in the visible region, and evaluated on the basis of the linear calibration curve set up on the same plate. Quantitative determination is demonstrated by means of the two amines, 5-amino-2,4,6-triiodoisophthalic acid-bis-(2,3-dihydroxypropyl-N-methylamide) (I) and 2,4,6-triiodo-3-aminobenzoic acid (II), in radiopaque contrast media (RCM). Both in the u.v. and visible regions, it is still possible to determine 0.1 μg of free aromatic amine in 3000 μg of radiopaque contrast medium acid (RCA), or 0.003% in terms of the amount of RCA used, with a maximum relative standard deviation of 4%. This method is more specific and more sensitive than that of diazotization in solution.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481557
    Standort Signatur Erwartet Verfügbarkeit
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