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  • American Association for the Advancement of Science  (35,779)
  • Nature Publishing Group  (30,828)
  • American Meteorological Society
  • MDPI Publishing
  • 2020-2024  (69)
  • 1995-1999  (38,949)
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  • 1
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    American Meteorological Society
    In:  EPIC3Journal of Climate, American Meteorological Society, 35(23), pp. 7811-7831, ISSN: 0894-8755
    Publication Date: 2023-06-23
    Description: Numerical simulations allow us to gain a comprehensive understanding of the underlying mechanisms of past, present, and future climate changes. The mid-Holocene (MH) and the last interglacial (LIG) were the two most recent warm episodes of Earth’s climate history and are the focus of paleoclimate research. Here, we present results of MH and LIG simulations with two versions of the state-of-the-art Earth system model AWI-ESM. Most of the climate changes in MH and LIG compared to the preindustrial era are agreed upon by the two model versions, including 1) enhanced seasonality in surface temperature that is driven by the redistribution of seasonal insolation; 2) a northward shift of the intertropical convergence zone (ITCZ) and tropical rain belt; 3) a reduction in annual mean Arctic sea ice concentration; 4) weakening and northward displacement of the Northern Hemisphere Hadley circulation, which is related to the decrease and poleward shift of the temperature gradient from the subtropical to the equator in the Northern Hemisphere; 5) a westward shift of the Indo-Pacific Walker circulation due to anomalous warming over the Eurasia and North Africa during boreal summer; and 6) an expansion and intensification of Northern Hemisphere summer monsoon rainfall, with the latter being dominated by the dynamic component of moisture budget (i.e., the strengthening of wind circulation). However, the simulated responses of the Atlantic meridional overturning circulation (AMOC) in the two models yield different results for both the LIG and the MH. AMOC anomalies between the warm interglacial and preindustrial periods are associated with changes in North Atlantic westerly winds and stratification of the water column at the North Atlantic due to changes in ocean temperature, salinity, and density.
    Repository Name: EPIC Alfred Wegener Institut
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  • 2
    Publication Date: 2023-02-25
    Description: Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 52(11), (2022): 2841–2852, https://doi.org/10.1175/jpo-d-22-0025.1.
    Description: Prediction of rapid intensification in tropical cyclones prior to landfall is a major societal issue. While air–sea interactions are clearly linked to storm intensity, the connections between the underlying thermal conditions over continental shelves and rapid intensification are limited. Here, an exceptional set of in situ and satellite data are used to identify spatial heterogeneity in sea surface temperatures across the inner core of Hurricane Sally (2020), a storm that rapidly intensified over the shelf. A leftward shift in the region of maximum cooling was observed as the hurricane transited from the open gulf to the shelf. This shift was generated, in part, by the surface heat flux in conjunction with the along- and across-shelf transport of heat from storm-generated coastal circulation. The spatial differences in the sea surface temperatures were large enough to potentially influence rapid intensification processes suggesting that coastal thermal features need to be accounted for to improve storm forecasting as well as to better understand how climate change will modify interactions between tropical cyclones and the coastal ocean.
    Description: This research was made possible by the NOAA RESTORE Science Program (NA17NOS4510101 and NA19NOS4510194) and the NASA Physical Oceanography program (80NSSC21K0553 and WBS 281945.02.25.04.67) and NOAA IOOS program via GCOOS (NA16NOS0120018). The authors declare that they have no competing interests.
    Keywords: Seas/gulfs/bays ; Atmosphere–ocean interaction ; Currents ; Tropical cyclones ; Buoy observations ; In situ oceanic observations
    Repository Name: Woods Hole Open Access Server
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  • 3
    Publication Date: 2023-02-25
    Description: Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 52(8), (2022): 1797–1815, https://doi.org/10.1175/JPO-D-21-0288.1.
    Description: Intruding slope water is a major source of nutrients to sustain the high biological productivity in the Gulf of Maine (GoM). Slope water intrusion into the GoM is affected by Gulf Stream warm-core rings (WCRs) impinging onto the nearby shelf edge. This study combines long-term mooring measurements, satellite remote sensing data, an idealized numerical ocean model, and a linear coastal-trapped wave (CTW) model to examine the impact of WCRs on slope water intrusion into the GoM through the Northeast Channel. Analysis of satellite sea surface height and temperature data shows that the slope sea region off the GoM is a hotspot of ring activities. A significant linear relationship is found between interannual variations of ring activities in the slope sea region off the GoM and bottom salinity at the Northeast Channel, suggesting the importance of WCRs in modulating variability of intruding slope water. Analysis of the mooring data reveals enhanced slope water intrusion through bottom-intensified along-channel flow following impingements of WCRs on the nearby shelf edge. Numerical simulations qualitatively reproduce the observed WCR impingement processes and associated episodic enhancement of slope water intrusion in the Northeast Channel. Diagnosis of the model result indicates that baroclinic CTWs excited by the ring–topography interaction are responsible for the episodically intensified subsurface along-channel inflow, which carries more slope water into the GoM. A WCR that impinges onto the shelf edge to the northeast of the Northeast Channel tends to generate stronger CTWs and cause stronger enhancement of the slope water intrusion into the GoM.
    Description: This study is supported by the National Science Foundation through Grant OCE-1634965.
    Keywords: Continental shelf/slope ; Channel flows ; Mesoscale processes ; In situ oceanic observations ; Satellite observations ; Numerical analysis/modeling
    Repository Name: Woods Hole Open Access Server
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  • 4
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    American Meteorological Society
    In:  EPIC3Journal of Climate, American Meteorological Society, pp. 1-40, ISSN: 0894-8755
    Publication Date: 2023-09-04
    Description: 〈jats:title〉Abstract〈/jats:title〉 〈jats:p〉Tipping points in the Earth system describe critical thresholds beyond which a single component, part of the system, or the system as a whole changes from one stable state to another. In the present-day Southern Ocean, the Weddell Sea constitutes an important dense-water formation site, associated with efficient deep-ocean carbon and oxygen transfer and low ice-shelf basal melt rates. Here, a regime shift will occur when continental shelves are continuously flushed with warm, oxygen-poor offshore waters from intermediate depth, leading to less efficient deep-ocean carbon and oxygen transfer and higher ice-shelf basal melt rates. We use a global ocean–biogeochemistry model including ice-shelf cavities and an eddy-permitting grid in the southern Weddell Sea to address the susceptibility of this region to such a system change for four 21〈jats:sup〉st〈/jats:sup〉-century emission scenarios. Assessing the projected changes in shelf–open ocean density gradients, bottom-water properties, and on-shelf heat transport, our results indicate that the Weddell Sea undergoes a regime shift by 2100 in the highest-emission scenario SSP5-8.5, but not yet in the lower-emission scenarios. The regime shift is imminent by 2100 in the scenarios SSP3-7.0 and SSP2-4.5, but avoidable under the lowest-emission scenario SSP1-2.6. While shelf-bottom waters freshen and acidify everywhere, bottom waters in the Filchner Trough undergo accelerated warming and deoxygenation following the system change, with implications for local ecosystems and ice-shelf basal melt. Additionally, deep-ocean carbon and oxygen transfer decline, implying that the local changes ultimately affect ocean circulation, climate, and ecosystems globally.〈/jats:p〉
    Repository Name: EPIC Alfred Wegener Institut
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  • 5
    Publication Date: 2023-04-26
    Description: Mechanisms behind the phenomenon of Arctic amplification are widely discussed. To contribute to this debate, the (AC)3 project was established in 2016 (www.ac3-tr.de/). It comprises modeling and data analysis efforts as well as observational elements. The project has assembled a wealth of ground-based, airborne, shipborne, and satellite data of physical, chemical, and meteorological properties of the Arctic atmosphere, cryosphere, and upper ocean that are available for the Arctic climate research community. Short-term changes and indications of long-term trends in Arctic climate parameters have been detected using existing and new data. For example, a distinct atmospheric moistening, an increase of regional storm activities, an amplified winter warming in the Svalbard and North Pole regions, and a decrease of sea ice thickness in the Fram Strait and of snow depth on sea ice have been identified. A positive trend of tropospheric bromine monoxide (BrO) column densities during polar spring was verified. Local marine/biogenic sources for cloud condensation nuclei and ice nucleating particles were found. Atmospheric–ocean and radiative transfer models were advanced by applying new parameterizations of surface albedo, cloud droplet activation, convective plumes and related processes over leads, and turbulent transfer coefficients for stable surface layers. Four modes of the surface radiative energy budget were explored and reproduced by simulations. To advance the future synthesis of the results, cross-cutting activities are being developed aiming to answer key questions in four focus areas: lapse rate feedback, surface processes, Arctic mixed-phase clouds, and airmass transport and transformation.
    Repository Name: EPIC Alfred Wegener Institut
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  • 6
    Publication Date: 2023-01-27
    Description: Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 52(8), (2022): 1705-1730, https://doi.org/10.1175/jpo-d-21-0243.1.
    Description: Formation and evolution of barrier layers (BLs) and associated temperature inversions (TIs) were investigated using a 1-yr time series of oceanic and air–sea surface observations from three moorings deployed in the eastern Pacific fresh pool. BL thickness and TI amplitude showed a seasonality with maxima in boreal summer and autumn when BLs were persistently present. Mixed layer salinity (MLS) and mixed layer temperature (MLT) budgets were constructed to investigate the formation mechanism of BLs and TIs. The MLS budget showed that BLs were initially formed in response to horizontal advection of freshwater in boreal summer and then primarily maintained by precipitation. The MLT budget revealed that penetration of shortwave radiation through the mixed layer base is the dominant contributor to TI formation through subsurface warming. Geostrophic advection is a secondary contributor to TI formation through surface cooling. When the BL exists, the cooling effect from entrainment and the warming effect from detrainment are both significantly reduced. In addition, when the BL is associated with the presence of a TI, entrainment works to warm the mixed layer. The presence of BLs makes the shallower mixed layer more sensitive to surface heat and freshwater fluxes, acting to enhance the formation of TIs that increase the subsurface warming via shortwave penetration.
    Description: SK is supported by JSPS Overseas Research Fellowships. JS and SK are supported by NASA Grant 80NSSC18K1500. JTF and the mooring deployment were funded by NASA Grants NNX15AG20G and 80NSSC18K1494. DZ is supported by NASA Grant 80NSSC18K1499. This publication is partially funded by the Cooperative Institute for Climate, Ocean, and Ecosystem Studies (CICOES) under NOAA Cooperative Agreement NA20OAR4320271, Contribution 2021-1152. This is PMEL Contribution 5268.
    Description: 2023-01-27
    Keywords: Ocean ; North Pacific Ocean ; Tropics ; Entrainment ; Oceanic mixed layer ; Salinity
    Repository Name: Woods Hole Open Access Server
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  • 7
    Publication Date: 2023-02-01
    Description: Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 52(8), (2022): 1927-1943, https://doi.org/10.1175/jpo-d-21-0124.1.
    Description: The Galápagos Archipelago lies on the equator in the path of the eastward flowing Pacific Equatorial Undercurrent (EUC). When the EUC reaches the archipelago, it upwells and bifurcates into a north and south branch around the archipelago at a latitude determined by topography. Since the Coriolis parameter (f) equals zero at the equator, strong velocity gradients associated with the EUC can result in Ertel potential vorticity (Q) having sign opposite that of planetary vorticity near the equator. Observations collected by underwater gliders deployed just west of the Galápagos Archipelago during 2013–16 are used to estimate Q and to diagnose associated instabilities that may impact the Galápagos Cold Pool. Estimates of Q are qualitatively conserved along streamlines, consistent with the 2.5-layer, inertial model of the EUC by Pedlosky. The Q with sign opposite of f is advected south of the Galápagos Archipelago when the EUC core is located south of the bifurcation latitude. The horizontal gradient of Q suggests that the region between 2°S and 2°N above 100 m is barotropically unstable, while limited regions are baroclinically unstable. Conditions conducive to symmetric instability are observed between the EUC core and the equator and within the southern branch of the undercurrent. Using 2-month and 3-yr averages, e-folding time scales are 2–11 days, suggesting that symmetric instability can persist on those time scales.
    Description: This work was supported by the National Science Foundation (Grants OCE-1232971 and OCE-1233282), the NASA Earth and Space Science Fellowship Program (Grant 80NSSC17K0443), and the Global Ocean Monitoring and Observing Program of the National Oceanographic and Atmospheric Administration (NA13OAR4830216). Color maps are from Thyng et al. (2016).
    Description: 2023-02-01
    Keywords: Currents ; In situ oceanic observations ; Instability ; Mixing ; Ocean dynamics ; Pacific Ocean ; Potential vorticity ; Tropics
    Repository Name: Woods Hole Open Access Server
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  • 8
    Publication Date: 2023-02-01
    Description: Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of the Atmospheric and Oceanic Technology 39(8), (2022): 1183-1198, https://doi.org/10.1175/jtech-d-21-0068.1.
    Description: Horizontal kinematic properties, such as vorticity, divergence, and lateral strain rate, are estimated from drifter clusters using three approaches. At submesoscale horizontal length scales O(1–10)km, kinematic properties become as large as planetary vorticity f, but challenging to observe because they evolve on short time scales O(hourstodays). By simulating surface drifters in a model flow field, we quantify the sources of uncertainty in the kinematic property calculations due to the deformation of cluster shape. Uncertainties arise primarily due to (i) violation of the linear estimation methods and (ii) aliasing of unresolved scales. Systematic uncertainties (iii) due to GPS errors, are secondary but can become as large as (i) and (ii) when aspect ratios are small. Ideal cluster parameters (number of drifters, length scale, and aspect ratio) are determined and error functions estimated empirically and theoretically. The most robust method—a two-dimensional, linear least squares fit—is applied to the first few days of a drifter dataset from the Bay of Bengal. Application of the length scale and aspect-ratio criteria minimizes errors (i) and (ii), and reduces the total number of clusters and so computational cost. The drifter-estimated kinematic properties map out a cyclonic mesoscale eddy with a surface, submesoscale fronts at its perimeter. Our analyses suggest methodological guidance for computing the two-dimensional kinematic properties in submesoscale flows, given the recently increasing quantity and quality of drifter observations, while also highlighting challenges and limitations.
    Description: This research was supported by the Office of Naval Research (ONR) Departmental Research Initiative ASIRI under Grant N00014-13-1-0451 (SE and AM) and Grant N00014-13-1-0477 (VH and LC). The authors thank the captain and crew of the R/V Roger Revelle, and Andrew Lucas with the Multiscale Ocean Dynamics group at the Scripps Institution for Oceanography for providing the FastCTD data collected in 2015, which was supported by ONR Grant N00014-13-1-0489, as well as Eric D’Asaro for helpful discussions and Lance Braasch for assistance with the drifter dataset. AM and SE further thank NSF (Grant OCE-I434788) and ONR (Grant N00014-16-1-2470) for support. VH and LC were additionally supported by ONR Grants N00014-15-1-2286, N00014-14-1-0183, N00014-19-1-26-91 and NOAA Global Drifter Program (GDP) Grant NA15OAR4320071.
    Description: 2023-02-01
    Keywords: Indian Ocean ; Eddies ; Frontogenesis/frontolysis ; Fronts ; Lagrangian circulation/transport ; Ocean circulation ; Ocean dynamics
    Repository Name: Woods Hole Open Access Server
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  • 9
    Publication Date: 2023-02-01
    Description: Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 35(17), (2022): 5465-5482, https://doi.org/10.1175/jcli-d-21-0671.1.
    Description: Understanding the contribution of ocean circulation to glacial–interglacial climate change is a major focus of paleoceanography. Specifically, many have tried to determine whether the volumes and depths of Antarctic- and North Atlantic–sourced waters in the deep ocean changed at the Last Glacial Maximum (LGM; ∼22–18 kyr BP) when atmospheric pCO2 concentrations were 100 ppm lower than the preindustrial. Measurements of sedimentary geochemical proxies are the primary way that these deep ocean structural changes have been reconstructed. However, the main proxies used to reconstruct LGM Atlantic water mass geometry provide conflicting results as to whether North Atlantic–sourced waters shoaled during the LGM. Despite this, a number of idealized modeling studies have been advanced to describe the physical processes resulting in shoaled North Atlantic waters. This paper aims to critically assess the approaches used to determine LGM Atlantic circulation geometry and lay out best practices for future work. We first compile existing proxy data and paleoclimate model output to deduce the processes responsible for setting the ocean distributions of geochemical proxies in the LGM Atlantic Ocean. We highlight how small-scale mixing processes in the ocean interior can decouple tracer distributions from the large-scale circulation, complicating the straightforward interpretation of geochemical tracers as proxies for water mass structure. Finally, we outline promising paths toward ascertaining the LGM circulation structure more clearly and deeply.
    Description: S.K.H. was supported by the Investment in Science Fund at WHOI and the John E. and Anne W. Sawyer Endowed Fund in Support of Scientific Staff. F.J.P. was supported by a Stanback Postdoctoral Fellowship at Caltech.
    Description: 2023-02-01
    Keywords: Diapycnal mixing ; Meridional overturning circulation ; Ocean circulation
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  • 10
    Publication Date: 2023-02-17
    Description: Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of the Atmospheric and Oceanic Technology 39(10), (2022): 1525–1539, https://doi.org/10.1175/jtech-d-21-0186.1.
    Description: The static and dynamic performances of the RBRargo3 are investigated using a combination of laboratory-based and in situ datasets from floats deployed as part of an Argo pilot program. Temperature and pressure measurements compare well to co-located reference data acquired from shipboard CTDs. Static accuracy of salinity measurements is significantly improved using 1) a time lag for temperature, 2) a quadratic pressure dependence, and 3) a unit-based calibration for each RBRargo3 over its full pressure range. Long-term deployments show no significant drift in the RBRargo3 accuracy. The dynamic response of the RBRargo3 demonstrates the presence of two different adjustment time scales: a long-term adjustment O(120) s, driven by the temperature difference between the interior of the conductivity cell and the water, and a short-term adjustment O(5–10) s, associated to the initial exchange of heat between the water and the inner ceramic. Corrections for these effects, including dependence on profiling speed, are developed.
    Keywords: Data processing/distribution ; In situ oceanic observations ; Profilers ; Oceanic
    Repository Name: Woods Hole Open Access Server
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  • 11
    Publication Date: 2023-02-28
    Description: Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 52(12),(2022): 3199-3219, https://doi.org/10.1175/jpo-d-22-0009.1.
    Description: The abyssal overturning circulation is thought to be primarily driven by small-scale turbulent mixing. Diagnosed water-mass transformations are dominated by rough topography “hotspots,” where the bottom enhancement of mixing causes the diffusive buoyancy flux to diverge, driving widespread downwelling in the interior—only to be overwhelmed by an even stronger upwelling in a thin bottom boundary layer (BBL). These water-mass transformations are significantly underestimated by one-dimensional (1D) sloping boundary layer solutions, suggesting the importance of three-dimensional physics. Here, we use a hierarchy of models to generalize this 1D boundary layer approach to three-dimensional eddying flows over realistically rough topography. When applied to the Mid-Atlantic Ridge in the Brazil Basin, the idealized simulation results are roughly consistent with available observations. Integral buoyancy budgets isolate the physical processes that contribute to realistically strong BBL upwelling. The downward diffusion of buoyancy is primarily balanced by upwelling along the sloping canyon sidewalls and the surrounding abyssal hills. These flows are strengthened by the restratifying effects of submesoscale baroclinic eddies and by the blocking of along-ridge thermal wind within the canyon. Major topographic sills block along-thalweg flows from restratifying the canyon trough, resulting in the continual erosion of the trough’s stratification. We propose simple modifications to the 1D boundary layer model that approximate each of these three-dimensional effects. These results provide local dynamical insights into mixing-driven abyssal overturning, but a complete theory will also require the nonlocal coupling to the basin-scale circulation.
    Description: We acknowledge funding support from National Science Foundation Awards 1536515, 1736109, and 2149080. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant 174530.
    Description: 2023-05-18
    Keywords: Abyssal circulation ; Diapycnal mixing ; Meridional overturning circulation ; Topographic effects ; Upwelling/downwelling ; Bottom currents/bottom water
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  • 12
    Publication Date: 2023-02-28
    Description: Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 52(6), (2022): 1091–1110, https://doi.org/10.1175/JPO-D-21-0068.1.
    Description: Hundreds of full-depth temperature and salinity profiles collected by Deepglider autonomous underwater vehicles (AUVs) in the North Atlantic reveal robust signals in eddy isopycnal vertical displacement and horizontal current throughout the entire water column. In separate glider missions southeast of Bermuda, subsurface-intensified cold, fresh coherent vortices were observed with velocities exceeding 20 cm s−1 at depths greater than 1000 m. With vertical resolution on the order of 20 m or less, these full-depth glider slant profiles newly permit estimation of scaled vertical wavenumber spectra from the barotropic through the 40th baroclinic mode. Geostrophic turbulence theory predictions of spectral slopes associated with the forward enstrophy cascade and proportional to inverse wavenumber cubed generally agree with glider-derived quasi-universal spectra of potential and kinetic energy found at a variety of locations distinguished by a wide range of mean surface eddy kinetic energy. Water-column average spectral estimates merge at high vertical mode number to established descriptions of internal wave spectra. Among glider mission sites, geographic and seasonal variability implicate bottom drag as a mechanism for dissipation, but also the need for more persistent sampling of the deep ocean.
    Description: This work was funded by NSF Grant 1736217 and would not have been possible without the help of Kirk O’Donnell, James Bennett, Noel Pelland, and all contributors to Deepglider development. We additionally thank the captain crew of the R/V Atlantic Explorer and the BATS team at the Bermuda Institute of Ocean Sciences, particularly Rod Johnson, as well as Seakeepers International for their professionalism, capability, and generous assistance in deploying and recovering gliders.
    Keywords: North Atlantic Ocean ; Eddies ; Mesoscale processes ; Turbulence ; Energy transport ; In situ oceanic observations ; Oceanic variability
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  • 13
    Publication Date: 2023-03-02
    Description: Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 52(12), (2022): 3221–3240, https://doi.org/10.1175/jpo-d-22-0010.1.
    Description: Small-scale mixing drives the diabatic upwelling that closes the abyssal ocean overturning circulation. Indirect microstructure measurements of in situ turbulence suggest that mixing is bottom enhanced over rough topography, implying downwelling in the interior and stronger upwelling in a sloping bottom boundary layer. Tracer release experiments (TREs), in which inert tracers are purposefully released and their dispersion is surveyed over time, have been used to independently infer turbulent diffusivities—but typically provide estimates in excess of microstructure ones. In an attempt to reconcile these differences, Ruan and Ferrari derived exact tracer-weighted buoyancy moment diagnostics, which we here apply to quasi-realistic simulations. A tracer’s diapycnal displacement rate is exactly twice the tracer-averaged buoyancy velocity, itself a convolution of an asymmetric upwelling/downwelling dipole. The tracer’s diapycnal spreading rate, however, involves both the expected positive contribution from the tracer-averaged in situ diffusion as well as an additional nonlinear diapycnal distortion term, which is caused by correlations between buoyancy and the buoyancy velocity, and can be of either sign. Distortion is generally positive (stretching) due to bottom-enhanced mixing in the stratified interior but negative (contraction) near the bottom. Our simulations suggest that these two effects coincidentally cancel for the Brazil Basin Tracer Release Experiment, resulting in negligible net distortion. By contrast, near-bottom tracers experience leading-order distortion that varies in time. Errors in tracer moments due to realistically sparse sampling are generally small (〈20%), especially compared to the O(1) structural errors due to the omission of distortion effects in inverse models. These results suggest that TREs, although indispensable, should not be treated as “unambiguous” constraints on diapycnal mixing.
    Description: We acknowledge funding support from National Science Foundation Awards 1536515 and 1736109. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant 174530. This research is also supported by the NOAA Climate and Global Change Postdoctoral Fellowship Program, administered by UCAR’s Cooperative Programs for the Advancement of Earth System Science (CPAESS) under Award NA18NWS4620043B.
    Description: 2023-05-18
    Keywords: Diapycnal mixing ; Diffusion ; Upwelling/downwelling ; Bottom currents/bottom water ; Tracers
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  • 14
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    American Meteorological Society
    In:  EPIC3Journal of Physical Oceanography, American Meteorological Society, 54(4), pp. 1003-1018, ISSN: 0022-3670
    Publication Date: 2024-04-25
    Description: Coastal upwelling, driven by alongshore winds and characterized by cold sea surface temperatures and high upper-ocean nutrient content, is an important physical process sustaining some of the oceans’ most productive ecosystems. To fully understand the ocean properties in eastern boundary upwelling systems, it is important to consider the depth of the source waters being upwelled, as it affects both the SST and the transport of nutrients toward the surface. Here, we construct an upwelling source depth distribution for parcels at the surface in the upwelling zone. We do so using passive tracers forced at the domain boundary for every model depth level to quantify their contributions to the upwelled waters. We test the dependence of this distribution on the strength of the wind stress and stratification using high-resolution regional ocean simulations of an idealized coastal upwelling system. We also present an efficient method for estimating the mean upwelling source depth. Furthermore, we show that the standard deviation of the upwelling source depth distribution increases with increasing wind stress and decreases with increasing stratification. These results can be applied to better understand and predict how coastal upwelling sites and their surface properties have and will change in past and future climates.
    Repository Name: EPIC Alfred Wegener Institut
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  • 15
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    American Meteorological Society
    In:  EPIC3Journal of Climate, American Meteorological Society, 37(6), pp. 2059-2080, ISSN: 0894-8755
    Publication Date: 2024-04-22
    Description: Heat stress is projected to intensify with global warming, causing significant socioeconomic impacts and threatening human health. Wet-bulb temperature (WBT), which combines temperature and humidity effects, is a useful indicator for assessing regional and global heat stress variability and trends. However, the variations of European WBT and their underlying mechanisms remain unclear. Using observations and reanalysis datasets, we demonstrate a remarkable warming of summer WBT during the period 1958–2021 over Europe. Specifically, the European summer WBT has increased by over 1.08C in the past 64 years. We find that the increase in European summer WBT is driven by both near-surface warming temperatures and increasing atmospheric moisture content. We identify four dominant modes of European summer WBT variability and investigate their linkage with the large-scale atmospheric circulation and sea surface temperature anomalies. The first two leading modes of the European WBT variability exhibit prominent interdecadal to long-term variations, mainly driven by a circumglobal wave train and concurrent sea surface temperature variations. The last two leading modes of European WBT variability mainly show interannual variations, indicating a direct and rapid response to large-scale atmospheric dynamics and nearby sea surface temperature variations. Further analysis shows the role of global warming and changes in midlatitude circulations in the variations of summer WBT. Our findings can enhance the understanding of plausible drivers of heat stress in Europe and provide valuable insights for regional decision-makers and climate adaptation planning.
    Repository Name: EPIC Alfred Wegener Institut
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  • 16
    Publication Date: 2024-01-12
    Description: Mantle-derived noble gases in volcanic gases are powerful tracers of terrestrial volatile evolution, as they contain mixtures of both primordial (from Earth's accretion) and secondary (e.g., radiogenic) isotope signals that characterize the composition of deep Earth. However, volcanic gases emitted through subaerial hydrothermal systems also contain contributions from shallow reservoirs (groundwater, crust, atmosphere). Deconvolving deep and shallow source signals is critical for robust interpretations of mantle-derived signals. Here, we use a novel dynamic mass spectrometry technique to measure argon, krypton, and xenon isotopes in volcanic gas with ultrahigh precision. Data from Iceland, Germany, United States (Yellowstone, Salton Sea), Costa Rica, and Chile show that subsurface isotope fractionation within hydrothermal systems is a globally pervasive and previously unrecognized process causing substantial nonradiogenic Ar-Kr-Xe isotope variations. Quantitatively accounting for this process is vital for accurately interpreting mantle-derived volatile (e.g., noble gas and nitrogen) signals, with profound implications for our understanding of terrestrial volatile evolution.
    Description: Published
    Description: eadg2566
    Description: OSV2: Complessità dei processi vulcanici: approcci multidisciplinari e multiparametrici
    Description: JCR Journal
    Keywords: noble gases ; earth degassing
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 17
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    American Meteorological Society
    In:  EPIC3Journal of Climate, American Meteorological Society, 37(8), pp. 2505-2518, ISSN: 0894-8755
    Publication Date: 2024-06-21
    Description: A fundamental statistic of climate variability is its spatiotemporal correlation function. Its complex structure can be concisely summarized by a frequency-dependent measure of the effective spatial degrees of freedom (ESDOF). Here we present, for the first time, frequency-dependent ESDOF estimates of global natural surface temperature variability from purely instrumental measurements, using the HadCRUT4 dataset (1850-2014). The approach is based on a newly developed method for estimating the frequency-dependent spatial correlation function from gappy data fields. Results reveal a multicomponent structure of the spatial correlation function, including a large-amplitude short-distance component (with weak time scale dependence) and a small-amplitude long-distance component (with increasing relative amplitude toward the longer time scales). Two frequency-dependent ESDOF measures are applied, each responding mainly to either of the two components. Both measures exhibit a significant ESDOF reduction from monthly to multidecadal time scales, implying an increase of the effective spatial scale of natural surface temperature fluctuations. Moreover, it is found that a good approximation to the global number of equally spaced samples needed to estimate the variance of global mean temperature is given, at any frequency, by the greater one of the two ESDOF measures, decreasing from ;130 at monthly to ;30 at multidecadal time scales. Finally, the multicomponent structure of the correlation function together with the detected ESDOF scaling properties indicate that the ESDOF reduction toward the longer time scales cannot be explained simply by diffusion acting on stochastically driven anomalies, as it might be suggested f rom simple stochastic-diffusive energy balance models.
    Repository Name: EPIC Alfred Wegener Institut
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  • 18
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    American Meteorological Society
    In:  EPIC3Journal of Climate, American Meteorological Society, 34(18), pp. 7373-7388, ISSN: 0894-8755
    Publication Date: 2024-06-21
    Description: Climate variability occurs over wide ranges of spatial and temporal scales. It exhibits a complex spatial covariance structure, which depends on geographic location (e.g., tropics vs extratropics) and also consists of a superposition of (i) components with gradually decaying positive correlation functions and (ii) teleconnections that often involve anticorrelations. In addition, there are indications that the spatial covariance structure depends on frequency. Thus, a comprehensive assessment of the spatiotemporal covariance structure of climate variability would require an extensive set of statistical diagnostics. Therefore, it is often desirable to characterize the covariance structure by a simple summarizing metric that is easy to compute from datasets. Such summarizing metrics are useful, for example, in the context of comparisons between climate models or between models and observations. Here we introduce a frequency-dependent version of a simple measure of the effective spatial degrees of freedom. The measure is based on the temporal variance of the global average of some climate variable, and its novel aspect consists in its frequency dependence. We also provide a clear geometric interpretation of the measure. Its easy applicability is demonstrated using near-surface temperature and precipitation fields obtained from a paleoclimate model simulation. This application reveals a distinct scaling behavior of the spatial degrees of freedom as a function of frequency, ranging from monthly to millennial scales.
    Repository Name: EPIC Alfred Wegener Institut
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  • 19
    Publication Date: 2024-05-29
    Description: NORP-SORP Workshop on Polar Fresh Water: Sources, Pathways and Impacts of Freshwater in Northern and Southern Polar Oceans and Seas (SPICE-UP) What: Up to 60 participants at a time and more than twice as many registrants in total from 20 nations and across experience levels met to discuss the current status of research on freshwater in both polar regions, future directions, and synergies between the Arctic and Southern Ocean research communities When: 19–21 September 2022 Where: Online
    Repository Name: EPIC Alfred Wegener Institut
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  • 20
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    American Meteorological Society
    In:  EPIC3Bulletin of the American Meteorological Society, American Meteorological Society, 104(9), pp. s1-s10, ISSN: 0003-0007
    Publication Date: 2024-05-29
    Description: 〈jats:title〉Abstract〈/jats:title〉 〈jats:p〉—J. BLUNDEN, T. BOYER, AND E. BARTOW-GILLIES〈/jats:p〉 〈jats:p〉Earth’s global climate system is vast, complex, and intricately interrelated. Many areas are influenced by global-scale phenomena, including the “triple dip” La Niña conditions that prevailed in the eastern Pacific Ocean nearly continuously from mid-2020 through all of 2022; by regional phenomena such as the positive winter and summer North Atlantic Oscillation that impacted weather in parts the Northern Hemisphere and the negative Indian Ocean dipole that impacted weather in parts of the Southern Hemisphere; and by more localized systems such as high-pressure heat domes that caused extreme heat in different areas of the world. Underlying all these natural short-term variabilities are long-term climate trends due to continuous increases since the beginning of the Industrial Revolution in the atmospheric concentrations of Earth’s major greenhouse gases.〈/jats:p〉 〈jats:p〉In 2022, the annual global average carbon dioxide concentration in the atmosphere rose to 417.1±0.1 ppm, which is 50% greater than the pre-industrial level. Global mean tropospheric methane abundance was 165% higher than its pre-industrial level, and nitrous oxide was 24% higher. All three gases set new record-high atmospheric concentration levels in 2022.〈/jats:p〉 〈jats:p〉Sea-surface temperature patterns in the tropical Pacific characteristic of La Niña and attendant atmospheric patterns tend to mitigate atmospheric heat gain at the global scale, but the annual global surface temperature across land and oceans was still among the six highest in records dating as far back as the mid-1800s. It was the warmest La Niña year on record. Many areas observed record or near-record heat. Europe as a whole observed its second-warmest year on record, with sixteen individual countries observing record warmth at the national scale. Records were shattered across the continent during the summer months as heatwaves plagued the region. On 18 July, 104 stations in France broke their all-time records. One day later, England recorded a temperature of 40°C for the first time ever. China experienced its second-warmest year and warmest summer on record. In the Southern Hemisphere, the average temperature across New Zealand reached a record high for the second year in a row. While Australia’s annual temperature was slightly below the 1991–2020 average, Onslow Airport in Western Australia reached 50.7°C on 13 January, equaling Australia's highest temperature on record.〈/jats:p〉 〈jats:p〉While fewer in number and locations than record-high temperatures, record cold was also observed during the year. Southern Africa had its coldest August on record, with minimum temperatures as much as 5°C below normal over Angola, western Zambia, and northern Namibia. Cold outbreaks in the first half of December led to many record-low daily minimum temperature records in eastern Australia.〈/jats:p〉 〈jats:p〉The effects of rising temperatures and extreme heat were apparent across the Northern Hemisphere, where snow-cover extent by June 2022 was the third smallest in the 56-year record, and the seasonal duration of lake ice cover was the fourth shortest since 1980. More frequent and intense heatwaves contributed to the second-greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. Glaciers in the Swiss Alps lost a record 6% of their volume. In South America, the combination of drought and heat left many central Andean glaciers snow free by mid-summer in early 2022; glacial ice has a much lower albedo than snow, leading to accelerated heating of the glacier. Across the global cryosphere, permafrost temperatures continued to reach record highs at many high-latitude and mountain locations.〈/jats:p〉 〈jats:p〉In the high northern latitudes, the annual surface-air temperature across the Arctic was the fifth highest in the 123-year record. The seasonal Arctic minimum sea-ice extent, typically reached in September, was the 11th-smallest in the 43-year record; however, the amount of multiyear ice—ice that survives at least one summer melt season—remaining in the Arctic continued to decline. Since 2012, the Arctic has been nearly devoid of ice more than four years old.〈/jats:p〉 〈jats:p〉In Antarctica, an unusually large amount of snow and ice fell over the continent in 2022 due to several landfalling atmospheric rivers, which contributed to the highest annual surface mass balance, 15% to 16% above the 1991–2020 normal, since the start of two reanalyses records dating to 1980. It was the second-warmest year on record for all five of the long-term staffed weather stations on the Antarctic Peninsula. In East Antarctica, a heatwave event led to a new all-time record-high temperature of −9.4°C—44°C above the March average—on 18 March at Dome C. This was followed by the collapse of the critically unstable Conger Ice Shelf. More than 100 daily low sea-ice extent and sea-ice area records were set in 2022, including two new all-time annual record lows in net sea-ice extent and area in February.〈/jats:p〉 〈jats:p〉Across the world’s oceans, global mean sea level was record high for the 11th consecutive year, reaching 101.2 mm above the 1993 average when satellite altimetry measurements began, an increase of 3.3±0.7 over 2021. Globally-averaged ocean heat content was also record high in 2022, while the global sea-surface temperature was the sixth highest on record, equal with 2018. Approximately 58% of the ocean surface experienced at least one marine heatwave in 2022. In the Bay of Plenty, New Zealand’s longest continuous marine heatwave was recorded.〈/jats:p〉 〈jats:p〉A total of 85 named tropical storms were observed during the Northern and Southern Hemisphere storm seasons, close to the 1991–2020 average of 87. There were three Category 5 tropical cyclones across the globe—two in the western North Pacific and one in the North Atlantic. This was the fewest Category 5 storms globally since 2017. Globally, the accumulated cyclone energy was the lowest since reliable records began in 1981. Regardless, some storms caused massive damage. In the North Atlantic, Hurricane Fiona became the most intense and most destructive tropical or post-tropical cyclone in Atlantic Canada’s history, while major Hurricane Ian killed more than 100 people and became the third costliest disaster in the United States, causing damage estimated at $113 billion U.S. dollars. In the South Indian Ocean, Tropical Cyclone Batsirai dropped 2044 mm of rain at Commerson Crater in Réunion. The storm also impacted Madagascar, where 121 fatalities were reported.〈/jats:p〉 〈jats:p〉As is typical, some areas around the world were notably dry in 2022 and some were notably wet. In August, record high areas of land across the globe (6.2%) were experiencing extreme drought. Overall, 29% of land experienced moderate or worse categories of drought during the year. The largest drought footprint in the contiguous United States since 2012 (63%) was observed in late October. The record-breaking megadrought of central Chile continued in its 13th consecutive year, and 80-year record-low river levels in northern Argentina and Paraguay disrupted fluvial transport. In China, the Yangtze River reached record-low values. Much of equatorial eastern Africa had five consecutive below-normal rainy seasons by the end of 2022, with some areas receiving record-low precipitation totals for the year. This ongoing 2.5-year drought is the most extensive and persistent drought event in decades, and led to crop failure, millions of livestock deaths, water scarcity, and inflated prices for staple food items.〈/jats:p〉 〈jats:p〉In South Asia, Pakistan received around three times its normal volume of monsoon precipitation in August, with some regions receiving up to eight times their expected monthly totals. Resulting floods affected over 30 million people, caused over 1700 fatalities, led to major crop and property losses, and was recorded as one of the world’s costliest natural disasters of all time. Near Rio de Janeiro, Brazil, Petrópolis received 530 mm in 24 hours on 15 February, about 2.5 times the monthly February average, leading to the worst disaster in the city since 1931 with over 230 fatalities.〈/jats:p〉 〈jats:p〉On 14–15 January, the Hunga Tonga-Hunga Ha'apai submarine volcano in the South Pacific erupted multiple times. The injection of water into the atmosphere was unprecedented in both magnitude—far exceeding any previous values in the 17-year satellite record—and altitude as it penetrated into the mesosphere. The amount of water injected into the stratosphere is estimated to be 146±5 Terragrams, or ∼10% of the total amount in the stratosphere. It may take several years for the water plume to dissipate, and it is currently unknown whether this eruption will have any long-term climate effect.〈/jats:p〉
    Repository Name: EPIC Alfred Wegener Institut
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  • 21
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    American Meteorological Society
    In:  EPIC3Bulletin of the American Meteorological Society, American Meteorological Society, 104(9), pp. s271-s321, ISSN: 0003-0007
    Publication Date: 2024-05-29
    Repository Name: EPIC Alfred Wegener Institut
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  • 22
    Publication Date: 2024-06-28
    Description: 〈jats:title〉Abstract〈/jats:title〉 〈jats:p〉This study quantifies the state-of-the-art in the rapidly growing field of seasonal Arctic sea ice prediction. A novel multi-model dataset of retrospective seasonal predictions of September Arctic sea ice is created and analyzed, consisting of community contributions from 17 statistical models and 17 dynamical models. Prediction skill is compared over the period 2001–2020 for predictions of Pan-Arctic sea ice extent (SIE), regional SIE, and local sea ice concentration (SIC) initialized on June 1, July 1, August 1, and September 1. This diverse set of statistical and dynamical models can individually predict linearly detrended Pan-Arctic SIE anomalies with skill, and a multi-model median prediction has correlation coefficients of 0.79, 0.86, 0.92, and 0.99 at these respective initialization times. Regional SIE predictions have similar skill to Pan-Arctic predictions in the Alaskan and Siberian regions, whereas regional skill is lower in the Canadian, Atlantic, and Central Arctic sectors. The skill of dynamical and statistical models is generally comparable for Pan-Arctic SIE, whereas dynamical models outperform their statistical counterparts for regional and local predictions. The prediction systems are found to provide the most value added relative to basic reference forecasts in the extreme SIE years of 1996, 2007, and 2012. SIE prediction errors do not show clear trends over time, suggesting that there has been minimal change in inherent sea ice predictability over the satellite era. Overall, this study demonstrates that there are bright prospects for skillful operational predictions of September sea ice at least three months in advance.〈/jats:p〉
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  • 23
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Acquisition of invasive/metastatic potential through protease expression is an essential event in tumor progression. High levels of components of the plasminogen activation system, including urokinase, but paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI1), have been ...
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  • 24
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] B-cell activation depends on the intensity of B-cell receptor cross-linking. Studies of haptenated antigens1 and vesicular stomatitis virus2 (VSV) have demonstrated a correlation between antigen repetitiveness and the degree to which B-cell activation is independent of T cells. Here, we compare ...
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  • 25
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    Nature medicine 4 (1998), S. 973-973 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] From the bench to the clinic (Annals of the New York Academy of Sciences, vol. 836) Edited by David M. Stoff & J. John Mann The New York Academy of Sciences, $80, 365 pp. ISBN1-57331 095-6, 1998 Reviewed By Angelo S. Halaris Department of Psychiatry, University of Mississippi, ...
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  • 26
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Ribozymes, catalytic RNA molecules that cleave a complementary mRNA sequence, have potential as therapeutics for dominantly inherited disease. Twelve percent of American patients with the blinding disease autosomal dominant retinitis pigmentosa (ADRP) carry a substitution of histidine for proline ...
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  • 27
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    Nature medicine 4 (1998), S. 974-974 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Genes associated with cancer Invasion, Metastasis and cell proliferation G.V. Sherbet & M.S. Lakshmi Academic Press, $85, 352 pp. ISBN: 0-126-39875-5, 1997 Reviewed By Daniel A. Haber Massachusetts General Hospital Cancer Center and Harvard Medical School,Charlestown, MA 02129 The ...
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  • 28
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    Nature medicine 4 (1998), S. 974-974 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease Øyvind Molberc, Stephen N. Mcadam, Roman Korner, Hanne Quarsten, Christel Kristiansen, Lars Madsen, Lars Fuccer, Helce Scott, Ove Noren, Peter Roepstorff, Knut E.A. ...
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  • 29
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 745-745 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Over the last decade or so, the number of papers listed by the US National Library of Medicine with the word Alzheimer in their title has grown steadily—in all, some twelve thousand are listed. Yet despite this level of activity and the fact that this disease, thought to represent the most ...
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  • 30
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 746-746 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] To the editor—Burton and Moore claim that “The experience of the biopharmaceutical companies in the HIV vaccine area has not been a happy one …. Interpretive loophole are ruthlessly exploited to beathe life into a corpse….” This is an opinion that we do not agree ...
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  • 31
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 869-869 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] To the editor—In his thoughtful review of Donald Kennedy's book Academic Duty (Nature Med. 4, 241–2, 1998), Michael Zigmond expresses the wish that “Kennedy had devoted more space to a discussion of why there is a relative lack of attention to duty on the part of the ...
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  • 32
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    Nature medicine 4 (1998), S. 869-869 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Zigmond replies—I found much to praise in my review of Kennedy's book, including the central premise—that faculty should devote more attention to the academic duty that accompanies their academic freedom. However, I also noted that Kennedy ignored many of the bases of the conditions he ...
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  • 33
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 870-870 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] To the editor—In an excellent News & Views article in the June issue1, Constantin Bona comments on two papers2,3 reporting promising results of idiotype vaccine experiments in mice. Bona suggests that anti-idiotype antibodies have not been adopted as cancer vaccines in humans and ...
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  • 34
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 872-872 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] After almost ten months of study, a 19-member panel has concluded that the National Institutes of Health (NIH) should seek more participation from patient advocacy groups and the general public to help set research priorities (Nature Med. 4; 375, 1998). The panel, chaired by Leon Rosenberg of the ...
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  • 35
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 873-873 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The World Health Organization (WHO) announced last month that it will ask national authorities in its 191 member states to take an inventory of laboratories which are storing wMd'type or genetically engineered polioviruses by January 1999. Laboratories housing samples will be asked to establish a ...
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  • 36
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 876-876 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The US Food and Drug Administration (FDA) has announced that it will publish new guidelines on xenotransplantation this fall in the Federal Register. They will advocate long-term monitoring of organ recipients and may prohibit the use of non-human primates as organ donors. The FDA will also ...
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  • 37
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 877-877 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Based on an evaluation of 215,000 scientific papers published between 1988–95, the UK is maintaining its share of the world's biomedical research publications at ten percent. This data comes from a report produced by the Wellcome Trust—Mapping the Landscape—which also shows that ...
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  • 38
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 887-888 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] DELVE INTO ANY textbook of immunology and marvel at the intricacies of the immune response. Then pay a visit to your friendly neighborhood transplant clinic and despair at the crude drugs used to suppress this complex system. The truth is that when it comes to designing ways to manipulate the ...
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  • 39
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 861-865 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Neoplasias are most responsive to medical intervention at early stages, prior to undergoing metastasis. When these disorders arise from known premalignant states, and if a detection method exists, the high-risk population can be screened to reduce patient morbidity and mortality. Organs where these ...
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  • 40
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 643-643 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] McInnes etal. reply—Shah etal. suggest that measurement of interleukin-15 (IL-15) levels in synovial fluid may be complicated by the presence of rheumatoid factor (RF) (although we note that the level of IL-15 recovered from ‘spiked’ SF in their assay was reduced in the presence ...
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  • 41
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] More than 40,000 people die annually from rabies worldwide1. Most of these fatalities occur in developing countries, where rabies is endemic, public health resources are inadequate and there is limited access to preventive treatment2. Because of the high cost of vaccines derived from cell culture, ...
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  • 42
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Substitutive therapy using fetal striatal grafts in animal models of Huntington disease (HD) have already demonstrated obvious beneficial effects on motor indices1. Using a new phenotypic model of HD recently designed in primates2,3, we demonstrate here complete and persistent recovery in a ...
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  • 43
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 978-980 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] NEUROCHEMICALS Four new opioid receptor agonists have been added to RBI's line of opioid products for neuroscience research. For example, BW373U86 hydrochloride is a novel potent, nonpeptide δ-opioid receptor agonist. Endomorphin-1 and endomorphin-2, on the other hand, are potent and ...
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  • 44
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    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 746-746 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] To the editor—In your recent Vaccine Supplement, Burton and Moore discuss HIV vaccine development1. It is unfortunate that when discussing how best to proceed toward a vaccine, the debate is too often couched in the oversimplified terminology of empiric vaccine testing versus further basic ...
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  • 45
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The transfer of apoptosis genes to tumors is one of the most promising strategies for cancer gene therapy. We have shown that massive apoptosis occurs when wild-type p53 expression is induced in glioma cells carrying a p53 gene mutation. However, adenovirus-mediated p53 gene transfer is ineffective ...
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  • 46
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The activity of fibroblast growth factor 2 (FGF-2) is stringently controlled. Inactive in undisturbed tissues, it is activated during injury and is critical for tissue repair. We find that this control can be imposed by the soluble syndecan-1 ectodomain, a heparan sulfate proteoglycan shed from ...
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  • 47
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    Notes: [Auszug] The p53 molecule might serve as a common tumor-associated antigen, as the tumor suppressor gene p53 is mutated and the p53 protein is often over-expressed in tumor cells. We report that effective immunity to p53 can be induced through an idiotypic network by immunization of mice with a monoclonal ...
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  • 48
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    Notes: [Auszug] Neuropeptide Y (NPY) is a 36-amino-acid neurotransmitter which is widely distributed throughout the central and peripheral nervous system1. NPY involvement has been suggested in various physiological responses including cardiovascular homeostasis2 and the hypothalamic control of food intake3. At ...
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  • 49
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    Nature medicine 4 (1998), S. 735-735 
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    Notes: [Auszug] AMUSING ANECDOTES FROM HIPPOCRATES TO HEART TRANSPLANTS By Richard Cordon St. Martin's Griffin, $12.95, 256 pp. ISBN 0-312-16763-6, 1997 REVIEWED BY PAUL R. MCHUGH Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine Baltimore, Maryland 21287 Richard ...
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  • 50
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    Nature medicine 4 (1998), S. 507-514 
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    Notes: [Auszug] Historical beginnings The sciences of vaccines and immunology1 were created by Jenner in 17962 in his demonstration of the scientific principles and realities for preventing smallpox by prior infection with the related but less virulent cowpox virus2. Jenner's findings lay fallow for more than a ...
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    Nature medicine 4 (1998), S. 525-531 
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    Notes: [Auszug] Drew Pardoll (Johns Hopkins Oncology Center) examines prospects for therapeutic cancer vaccines. Considering how it is that the immune system fails to recognize and destroy cancer cells, Pardoll discusses contemporary vaccine approaches aimed at exposing cancer antigens to the cellular arm of the ...
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    Nature medicine 4 (1998), S. 536-536 
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    Notes: [Auszug] The controversy surrounding the effect of specific chemokine receptor polymorphisms on HIV disease progression1,2 highlights the need for synthesis of the pertinent evidence. It also suggests that large-scale international collaborations3,4 are indispensable when it comes to addressing important ...
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    Nature medicine 4 (1998), S. 538-538 
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    Notes: [Auszug] Soldan et al. reply—We agree with Fillet et al. that serological studies in MS are difficult to interpret due to defects in immunoregulation which often result in increased antibody titers in MS patients. However we demonstrated that the IgG and IgM antibody responses of MS patients to two ...
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    Nature medicine 4 (1998), S. 540-540 
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    Notes: [Auszug] The Australian government has voted to continue funding the Cooperative Research Centre (CRC) program, which is dedicated to encouraging industries and academic research organizations to work together. The decision has been awaited since a review of the program in the second half of 1997, led by ...
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    Nature medicine 4 (1998), S. 542-542 
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    Notes: [Auszug] 1,500 crickets, some still in the egg stage, have joined the mice, rats, snails and fish aboard Neurolab—the Columbia space shuttle flight dedicated to neuroscience research, which blasted off from Cape Canaveral on April 17th. Crickets are used as a model of central nervous system (CNS) ...
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  • 56
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    Nature medicine 4 (1998), S. 645-645 
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    Notes: [Auszug] To the editor—Recently Schwartz1 reviewed the importance of two new hypo-thalamic peptides, orexin A, 33 amino acids, and orexin B, 28 amino acids, in energy homeostasis. Molecular genetic studies in rodents have provided convincing evidence supporting relevant roles for several hypothalamic ...
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  • 57
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    Nature medicine 4 (1998), S. 648-649 
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    Notes: [Auszug] Within weeks of accusations by the dean of Public Health at Allegheny University, Jonathan Mann, that the National Institutes of Health (NIH) is violating human rights through its failure to test current HIV vaccine candidates in Phase III trials (Nature, 392; 527 1998), 75 of America's leading ...
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  • 58
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    Nature medicine 4 (1998), S. 650-650 
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    Notes: [Auszug] It seemed too good to be true. And, ultimately, it was. For a few chaotic days, a story prominently displayed on the front page of the normally restrained New York Times prompted a public frenzy among cancer patients, researchers and the media. The piece, written by Gina Kolata, one of the paper's ...
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    Nature medicine 4 (1998), S. 652-652 
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    Notes: [Auszug] In an effort to ‘stimulate and capture the public's imagination,’ the world's largest medical research charity, the Wellcome Trust, is spending £80,000 ($125,000) on an initiative that brings artists and scientists together. Now in its second year, the program funds ...
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    Nature medicine 4 (1998), S. 655-657 
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    Notes: [Auszug] For any therapy to be successful, it must satisfy two requirements: it must be effective in the in vivo microenvironment and it must reach target cells in vivo in optimal quantities1. Extraordinary advances in molecular biology and biotechnology have helped to identify novel targets and develop a ...
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    Nature medicine 4 (1998), S. 661-662 
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    Notes: [Auszug] NOT TOO LONG ago, a renowned cardiologist asked a colleague, a respected immunologist, whether there was any link between the heart and lymphocytes. The best answer they could come up with was that the heart pumps lymphocytes around the body. To the same question, a heart surgeon said that ...
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    Nature medicine 4 (1998), S. 668-669 
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    Notes: [Auszug] IDIOTYPES ARE ANTIGENIC determinants and phenotypic markers of V-region genes that encode the specificity of antibodies (and T-cell receptors)1. The diversity of antigen receptors on lymphocytes is reflected in the diversity of idiotypes. This means that statistically the antigen dictionary of both ...
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  • 63
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    Notes: [Auszug] A novel strategy for anti-viral intervention of hepatitis B virus (HBV) through the disruption of the proper folding1 and transport2 of the hepadnavirus glycoproteins is described. Laboratory reared woodchucks chronically infected with woodchuck hepatitis virus (WHV) were treated with ...
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  • 64
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    Notes: [Auszug] Angiogenesis, the formation of new blood vessels, is a requirement for malignant tumor growth and metastasis1–3. In the absence of angiogenesis, local tumor expansion is suppressed at a few millimeters and cells lack routes for distant hematogenous spread. Clinical studies have demonstrated ...
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  • 65
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    Notes: [Auszug] Huntington's disease is an autosomal dominant, inherited disorder that results in progressive degeneration of the basal ganglia (especially the neostriatal caudate nucleus and putamen) and other forebrain structures and is associated with a clinical profile of movement, cognitive and psychiatric ...
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    Nature medicine 4 (1998), S. 742-744 
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    Notes: [Auszug] ES CELL STUDIES Day 12 hematopoietic embryoid bodies. StemCell Technologies has recently launched a line of products under the ES-Cult name for the in vitro maintenance and hematopoietic differentiation of mouse embryonic stem (ES) cells. Two-step in vitro differentiation of ES cells in ...
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    Nature medicine 4 (1998), S. 475-476 
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    Notes: [Auszug] At millennium's end, vaccinology presents some startling contrasts. On the one hand, the expanded program on immunization represents one of the great public health triumphs of all time. Poliomyelitis is on the pathway to eradication, measles transmission has ceased in many countries, BCG and ...
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    Nature medicine 4 (1998), S. 478-478 
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    Notes: [Auszug] There is perhaps no better single illustration of the commerical importance of vaccines as medicines for the next century than thedeal signed between the two British companies, Powderject Pharmaceuticals and Glaxo Wellcome (GW). With a potential total value of around $300 million, the ...
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    Nature medicine 4 (1998), S. 480-484 
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    Notes: [Auszug] Shortly after the assassination of Prime Minister Indira Gandhi in 1984, Jim Grant, Administrator of UNICEF and Hafdan Mahler, Director-General of World Health Organization (WHO), flew to New Delhi on an extraordinary mission. They proposed to her surviving son, Rajiv, that instead of building a ...
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    Nature medicine 4 (1998), S. 499-500 
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    Notes: [Auszug] DIARRHEAL DISEASES ACCOUNT for three million deaths annually, mostly among children1. Overcrowded suburbs in expanding Third World cities, poor rural dwellings and refugee camps are sites where the lack of hygiene makes diarrhea an overwhelming public health problem. Furthermore, the ...
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    Nature medicine 4 (1998), S. 500-501 
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    Notes: [Auszug] ASTHMA is A modern plague, affecting more than ten percent of children in many westernized societies. The prevalence of asthma and other allergic diseases has doubled in the last twenty years. Although much is known about the ubiquitous environmental antigens (known as allergens) that precipitate ...
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    Nature medicine 4 (1998), S. 506-506 
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    Notes: [Auszug] The fall of the Soviet Union brought independence, democracy, and the promise of a new and brighter future to the Russian people. But it also heralded a renewed threat from infectious diseases. In the decade since the fall, Russia has experienced a dramatic increase in diphtheria, measles and ...
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  • 73
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    Notes: [Auszug] The Epstein-Barr virus nuclear antigen 1 contains a glycine-alanine repeat that inhibits in cis MHC class l-restricted presentation. We report here that insertion of a minimal glycine-alanine repeat motif in different positions of IκBα protects this NF-κB inhibitor from ...
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    Nature medicine 4 (1998), S. 535-535 
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    Notes: [Auszug] Two papers in this issue demand the attention of all those interested in developing plant-based Pharmaceuticals and vaccines and other therapies to fight infectious diseases. The first demonstrates the successful use of a plant-derived secretory antibody to prevent bacterial infection and the ...
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    Nature medicine 4 (1998), S. 391-392 
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    Notes: [Auszug] CROSS-SPECIES INFECTION has become a hot topic again. The link between new variant Creutzfeld-Jakob disease (nvCJD) and bovine spongiform en-cephalopathy, the Sin Nombre han-tavirus outbreak in the US Southwest, concerns about virus transmission via xenotransplantation, and the recent deaths in ...
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    Nature medicine 4 (1998), S. 394-395 
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    Notes: [Auszug] THE PRESENIUN GENES (PS) are the most common cause of early-onset familial Alzheimer's disease (AD). Until recently the only difference between the clinical syndrome associated with presenilin mutations and classic AD was an earlier age of onset12. However, four families have now been ...
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  • 77
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    Notes: [Auszug] Studying the transmission of simian retroviruses to humans can help define the importance of these infections to public health. We identified a substantial prevalence (4/231, 1.8%) of infection with simian foamy viruses (SFV) among humans occupationally exposed to nonhuman primates. Evidence ...
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  • 78
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    Notes: [Auszug] The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCC inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a ...
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  • 79
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    Notes: [Auszug] At a position equivalent to the gene encoding the saimiri transforming protein (STP) of herpesvirus saimiri (HVS), Kaposi's sarcoma-associated herpesvirus (KSHV) contains a distinct open reading frame called K1. Although KSHV and HVS are related members of the rhadinovirus subgroup of gamma ...
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    Nature medicine 4 (1998), S. 555-557 
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    Notes: [Auszug] A RECENT PAPER by Gould and colleagues describes for the first time the generation of new nerve cells in the brains of adult marmoset monkeys (more specifically in the hippocampal formation of the temporal lobe)1. This finding can be added to a growing list of reports2–5 that together render ...
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    Nature medicine 4 (1998), S. 552-553 
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    Notes: [Auszug] ONE OF THE most exciting aspects of contemporary biomedical research is the application of new tools to the study of organisms that for various reasons have not been considered amenable to experimental analysis. An example is the mosquito vector of malaria, which is arguably the most important ...
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    Nature medicine 4 (1998), S. 561-562 
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    Notes: [Auszug] ALTHOUGH DAMAGE TO the human brain or spinal cord is generally regarded as irreversible from a neurological perspective, it is well recognized that physical rehabilitation after neurological injury aids recovery of behavioral function. It is only during the last 20 years that it has become widely ...
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  • 83
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    Notes: [Auszug] The cyclin-dependent kinase inhibitor p27Kip1 controls cell proliferation in response to normal mitogenic stimuli. We show here that p27Kip1 also safeguards against excessive cell proliferation in specific pathophysioiogic settings. We used experimental glomerulonephritis as a paradigm for immune ...
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  • 84
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    Notes: [Auszug] Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor tissue is limited and variable, an alternative and genetically modifiable non-human source of tissue would be valuable. We have generated ...
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    Notes: [Auszug] In situ killing of tumor cells using suicide gene transfer to generate death by a non-apoptotic pathway was associated with high immunogenicity and induction of heat shock protein (hsp) expression. In contrast, a syngeneic colorectal tumor line, CMT93, killed predominantly by apoptosis, showed ...
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    Notes: [Auszug] Germany was not among the 20 European countries which signed the European Convention on Human Rights and Biomedicine treaty banning human cloning this January. However, the German research-funding body, the Deutsche Forschungsge-meinschaf (DFG) and the country's science ministry, the ...
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  • 87
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    Notes: [Auszug] Alzheimer's disease is associated with the intraparenchymal growth of plaque-like amyloid deposits1–3. Amyloid plaques are formed by the progressive deposition and transformation of soluble amyloid β-protein monomers into insoluble and fibrillar aggregates that contain amyloid ...
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  • 88
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    Notes: [Auszug] Many genes and signalling pathways controlling cell proliferation, death and differentiation, as well as genomic integrity, are involved in cancer development. New techniques, such as serial analysis of gene expression and cDNA microarrays, have enabled measurement of the expression of thousands of ...
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    Nature medicine 4 (1998), S. 857-858 
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    Notes: [Auszug] By P. S. Harper & A.J. Clarke BIOS Scientific Publishers, £19.95, 264 pp. ISBN1-859962-068, 1997 REVIEWED BY ARNO G. MOTULSKY University of Washington Department of Medicine and Genetics RG-25 Seattle, WA 98195-0001 The two British authors of this book, both from the Institute of ...
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    Nature medicine 4 (1998), S. 865-866 
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    Notes: [Auszug] IT's A KNOCKOUT Three new transgenic mice deficient in Fc receptors for studying immune responses—the FcRγ knockout, FcγRII knockout and the FcRγ/FcγRII double knockout mouse models—are now available from Taconic. The FcRγ and the FcγRII are ...
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    Nature medicine 4 (1998), S. 643-643 
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    Notes: [Auszug] To the editor—Mclnnes et al. have reported a potential role for interleukin-15 (IL-15) in the pathogenesis of rheumatoid arthritis (RA)U. The in vitro functional data in support of their hypothesis rest, in part, on the very high concentrations of IL-15 detected in synovial fluid of patients ...
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    Notes: [Auszug] In the February issue, Mehta and colleagues1 reported that the application of an external stent to a pig saphenous vein graft reduced medial thickening, intima formation and cell proliferation associated with reduced PDGF expression. As the study was conducted on normolipidemic animaJs, no ...
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    Nature medicine 4 (1998), S. 647-647 
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    Notes: [Auszug] The US Post Office has unveiled a new postage stamp to be sold in support of breast cancer research. The ‘semipostal’ stamp, which goes on sale in August, will cost 8 cents more than regular postage and the extra proceeds will go to support breast cancer research programs at the ...
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    Notes: [Auszug] Britain has too many cancer research charities, with the result that funds donated by the public for research are not being used as effectively as they could be, according to Gordon McVie, the head of one of the largest such bodies, the Cancer Research Campaign (CRC). In a speech last month that ...
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  • 95
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    Notes: [Auszug] Both cellular and humoral immunodeficiency develop in vivo after prolonged infection with HIV-1, but the mechanisms are unclear1. Initial infection with HIV-1 is transmitted by macrophage (M)-tropic/non-syncytia-inducing (NSI) viruses2,3, which hyperactivate the immune system4,5, and, in one view, ...
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    Notes: [Auszug] The feasibility of a malaria vaccine is supported by the fact that children in endemic areas develop naturally acquired immunity to disease. Development of disease immunity is characterized by a decrease in the frequency and severity of disease episodes over several years despite almost continuous ...
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  • 97
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    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 363-363 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Murine γ-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-γ responsiveness: A new model for virus-induced vascular disease K.E. WECK, A.j. DAL CANTO, j.D. GOULD, A.K. O'GUIN, K.A. ROTH, J.E. SAFFITZ, S.H. SPECK & H.W. VIRGIN Nature Med. 3, 1346-1353 ...
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  • 98
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    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 384-384 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Some days a good laugh is hard to find in a neurosur-geon's operating room, but Itzhak Fried and his colleagues (University of California, Los Angeles) got an entertaining surprise recently while they were mapping the brain of a 16 year-old epileptic girl {Nature 391, 650, 1998). Electrical ...
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  • 99
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    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 385-386 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] DESPITE FREQUENT AND sometimes severe fluctuations in energy intake and expenditure, the amount of fuel stored in the form of adipose tissue remains remarkably stable over the adult lifetime of most mammals. Nearly fifty years ago, this observation led to the hypothesis that body adiposity is ...
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  • 100
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    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 388-389 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] MARBURG AND EBOLA virus are filoviruses that cause fulminant hemorrhagic fever in humans and nonhuman primates, killing up to 90 percent of infected individuals. Since the discovery of Marburg virus in 1967 and its better known cousin, Ebola, a few years later, these pathogens have been cause for ...
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