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  • Chemistry  (76,809)
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  • AERODYNAMICS
  • Pflanzenkrankheit
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  • 1
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    Final report on the updating service on environmental chemicals in freshwater for the period 9.1.89 to 9.7.89 (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5238 | 1256 | 2011-09-29 15:13:42 | 5238 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: This report presents five batches of data which have been despatched to the Joint Research Centre, Ispra. The data as been allocated to various ECDIN (Environmental Chemicals Data and Information Network) files. The data comprises environmental chemicals in the freshwater environment, taking in paricular consideration: aquatic toxicity, bioaccumulation, metabolism and elimination biodegradation.
    Keywords: Chemistry ; Ecology ; Limnology ; Data ; Data processing ; Data collections ; Chemical compounds ; Toxicity ; Bioaccumulation ; Biodegradation ; Metabolism
    Repository Name: AquaDocs
    Type: monograph
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  • 2
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    Changes of water quality and sediment phosphorus of a small productive lake following decreased phosphorus loading (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5293 | 1256 | 2011-09-29 15:08:09 | 5293 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: Esthwaite Water is the most productive or eutrophic lake in the English Lake District. Since 1945 its water quality has been determined from weekly or biweekly measurements of temperature, oxygen, plant nutrients and phytoplankton abundance. The lake receives phosphorus from its largely lowland-pasture catchment, sewage effluent from the villages of Hawkshead and Near Sawrey, and from a cage-culture fish farm. From 1986 phosphorus has been removed from the sewage effluent of Hawkshead which was considered to contribute between 47% and 67% of the total phosphorus loading to the lake. At the commencement of phosphorus removal regular measurements of phosphorus in the superficial 0-4 cm layer of lake sediment were made from cores collected at random sites. Since 1986 the mean annual concentration of alkali-extractable sediment phosphorus has decreased by 23%. This change is not significant at the 5% level but nearly so. There has been no marked change in water quality over this period. Summer dominance of blue-green algae which arose in the early 1980s after decline of the previous summer forms, Ceratium spp., has been maintained. Improvement in water quality is unlikely to be achieved at the present phosphorus loading.
    Keywords: Chemistry ; Limnology ; Pollution ; Eutrophication ; Freshwater lakes ; Limnological surveys ; Phosphorus ; Phytoplankton ; Primary production ; Sediment analysis ; Water quality ; England ; Esthwaite Water
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  • 3
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    The changing chemical composition of chalk streams and rivers (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5157 | 3949 | 2011-09-29 15:19:58 | 5157 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-08
    Description: The area studied was the River Frome system below Dorchester. The main river has its origins mainly in chalk springs, although some of its tributaries have surface run-off from farm lands and heath-lands. Thus the chemistry of the river is affected by changes in land practice and differences in the geology of the catchment area. Regular chemical analysis of chalk waters started at the River Laboratory in 1964, Regular weekly analyses have been carried out since 1965 at Bere Stream (a small chalk stream) and the River Frome (a large chalk stream); also single samples have been analysed to provide preliminary information. In 1970-71 an attempt was made to discover the contribution each main source made to the flow and chemical composition of the River Frome. Results of these investigations are presented in the paper.
    Keywords: Chemistry ; Environment ; Chemical analysis ; Chemical composition ; Rivers ; Stream flow ; Annual report ; England ; Dorset
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  • 4
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    Geochemistry of lipids in lacustrine sediments (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5171 | 3949 | 2011-09-29 15:18:48 | 5171 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-08
    Description: An explanation of the basic premises of the subject and its terminology is given. The article then outlines aspects of research on the organic material found in lacustrine sediments, and the analytical methods involved.
    Keywords: Chemistry ; Earth Sciences ; Diagenesis ; Freshwater lakes ; Geochemistry ; Lipids ; Sediment analysis ; Annual report
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    Format: 45-56
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  • 5
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    Joint research project on the aquatic ecotoxicity of organo-aluminium: Chemical reactions. First interim report (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5225 | 1256 | 2011-09-29 15:12:36 | 5225 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: The overall goal of the joint research project is to relate the chemical reactions involved in the formation of organo-aluminium complexes under acid conditions to their toxic effects on the physiology of aquatic organisms. Finally, this research is intended to predict toxic effects arising from acidity and aluminium under varying environmental conditions. This interim report examines the chemical modelling of ion-binding by humic substances where a computer model has been developed and is being tested using field data, and conditions required for the precipitation of aluminium in surface waters.
    Keywords: Chemistry ; Limnology ; Pollution ; Modelling ; Models ; Humic acids ; Surface water ; Aluminium compounds ; Aluminium ; Ions ; Toxicity ; England ; Duddon River
    Repository Name: AquaDocs
    Type: monograph
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    Format: 26
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  • 6
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    Decomposition in lake sediments: bacterial action and interaction (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5239 | 3949 | 2011-09-29 15:13:47 | 5239 | Freshwater Biological Association
    Details
    Publication Date: 2021-06-24
    Description: This review discusses the processes involved in the decomposition of organic carbon derived initially from structural components of algae and other primary producers. It describes how groups of bacteria interact in time and space in a eutrophic lake. The relative importance of anaerobic and aerobic processes are discussed. The bulk of decomposition occurs within the sediment. The role of bacteria in the nitrogen cycle and the iron cycle, and in sulphate reduction and methanogenesis as the terminal metabolism of organic carbon are described.
    Keywords: Biology ; Chemistry ; Anaerobic bacteria ; Bacteria ; Biodegradation ; Carbon cycle ; Eutrophic lakes ; Fresh water ; Geochemical cycle ; Iron ; Manganese ; Nitrates ; Nitrogen cycle ; Organic carbon ; Oxygen consumption ; Partical size ; Sedimentation ; Sulphates ; Sulphur ; Annual report
    Repository Name: AquaDocs
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  • 7
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    Biological and climatic influences on the dace Leuciscus leuciscus in a southern chalk-stream (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5247 | 3949 | 2011-09-29 15:08:19 | 5247 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: The dace, Leuciscus leuciscus (L.) is an important cyprinid in terms of population biomass in chalk streams of southern England. Dace recruitment has been shown to vary widely from year to year and it is thought that this variation is largely as a result of the influence of abiotic factors, chiefly water temperature. From 1968 to 1981 there was a thirteen-fold difference in the year class structure index between the minimum index (0.25 in 1972) and the maximum (3.21 in 1976). The problems of such variation, especially those that could ensue from a succession of poor year-classes, are offset by the spread of reproductive effort by each female over several years.
    Keywords: Biology ; Chemistry ; Fisheries ; Abiotic factors ; Age composition ; Annual variations ; Climate ; Fecundity ; Fish eggs ; Fish larvae ; Freshwater fish ; Life history ; Mortality ; Population dynamics ; Predation ; Recruitment ; Sexual reproduction ; Survivial ; Water temperature ; Cyprinidae ; Leuciscus leuciscus ; England ; Dorset ; Chalk streams ; Annual report
    Repository Name: AquaDocs
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    Format: 83-96
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  • 8
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    Analysis and adsorption of phosalone on aquatic sediment (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5257 | 1256 | 2011-09-29 15:09:23 | 5257 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: Phosalone is a non systematic, wide spectrum organophosphate pesticide which was discovered in 1961 in the laboratories of the Societe des Usines Chimique Rhone-Poulenc in France. It has been approved for commercial use since 1964 in France, in Australia since 1966, in the United Kingdom in 1967 and in many other countries including Japan, Egypt, USSR and the USA. This study provides a full literature review on all aspects of phosalone including its physical, biological and chemical characteristics, and analytical methods of analysis with particular reference to soils/sediments. Furthermore, it aims to develop a method for the determintion of phosalone in aquatic sediments and to determine the adsorption of phosalone onto kaolinite.
    Keywords: Chemistry ; Limnology ; Pollution ; Insecticides ; Metabolism ; Toxicity ; Biodegradation ; Adsorption
    Repository Name: AquaDocs
    Type: monograph
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    Format: application/pdf
    Format: 54
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  • 9
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    Petroleum hydrocarbons in fresh waters: a preliminary desk study and bibliography (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5278 | 1256 | 2011-09-29 15:11:09 | 5278 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: A literature survey was carried out into the effects of petroleum hydrocarbons in freshwater, from the toxicity, biodegradability and concentration aspects. It was supplemented by a selective search on hydrocarbons in the marine environment for comparison. The aim was to determine the major inputs of these hydrocarbons, their accumulation, effects and fate in freshwaters. The search was confined to the period 1965-1978. The bibliography contains 390 references, divided by subject.
    Keywords: Chemistry ; Limnology ; Pollution ; literature reviews ; petroleum ; toxicity ; biodegradation
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  • 10
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    Concentrations of major ions in the stream water of the River Duddon, England, 1970-1974 [Dataset] (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5349 | 1256 | 2011-05-13 11:55:43 | 5349 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-10
    Description: This dataset provides raw data of chemical analyses made during studies on seasonal variations of some major ions in the stream water of the River Duddon in Cumbria. Measurements of sodium, calcium, potassium, magnesium and chloride ions and pH were taken at 5 stations in the River Duddon between January 1970 and August 1974.
    Description: This data was used in the publication: Carrick, T.R. & Sutcliffe, D.W.: Concentrations of Major Ions in Streams on Catchments of the River Duddon (1971-1974) and Windermere (1975-1978), English Lake District. Freshwater Biological Association, Ambleside, UK, 1983 (FBA Occasional Publications 22)
    Keywords: Chemistry ; Limnology ; Calcium ; chlorides ; fresh water ; ions ; magnesium ; potassium ; seasonal variations ; sodium ; water analysis ; dataset
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  • 11
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    Analysis of stream waters in the catchment of Lake Windermere (1975-1978), England [Dataset] (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5351 | 1256 | 2011-05-13 11:55:21 | 5351 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-10
    Description: This dataset provides raw data of chemical analyses made during studies on seasonal variations of some major ions in the stream water of the catchment of Lake Windermere in Cumbria. Measurements of sodium, calcium, potassium, magnesium, chloride ions and pH were taken at 37 stations in the catchment between 1975 and 1978.
    Description: This data was used in the publication: Carrick, T.R. & Sutcliffe, D.W.: Concentrations of major ions in streams on catchments of the River Duddon (1971-1974) and Windermere (1975-1978), English Lake District. Freshwater Biological Association, Ambleside, UK, 1983 (FBA Occasional Publications 22)
    Keywords: Chemistry ; Limnology ; Calcium ; chlorides ; fresh water ; ions ; magnesium ; potassium ; seasonal variations ; sodium ; water analysis ; England ; Lake Windermere ; dataset
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  • 12
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    Concentrations of major ions in 182 tarns in the English Lake District (1953-1978) [Dataset] (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5354 | 1256 | 2011-09-16 12:01:28 | 5354 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-10
    Description: This dataset provides raw data of chemical analyses made during studies on seasonal variations of 182 tarns in the English Lake District, Cumbria. Measurements of sodium, calcium, potassium, magnesium, pH, chloride ions, alkalinity, sulphite, strong acids and nitrate were taken between 1953 and 1978.
    Description: This data was used in the publication: Carrick, T.R. & Sutcliffe, D.W.: Concentrations of major ions in lakes and tarns on the English Lake District (1953-1978). Freshwater Biological Association, Ambleside, UK, 1982 (FBA Occasional Publications 16)
    Keywords: Chemistry ; Limnology ; Calcium ; chlorides ; fresh water ; ions ; magnesium ; potassium ; seasonal variations ; sodium ; water analysis ; alkalinity ; England ; Lake District ; dataset
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  • 13
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    Analyses of treated sewage effluent from Grasmere Treatment Unit (1974-1976), England [Dataset] (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5352 | 1256 | 2012-07-04 19:32:47 | 5352 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-10
    Description: This dataset provides raw data of chemical analyses made during studies on seasonal variations of treated sewage effluent from Grasmere Treatment Unit in Cumbria. Measurements of sodium, calcium, potassium, magnesium and chloride ions were taken between 1974 and 1976.
    Description: This data was used in the publication: Carrick, T.R. & Sutcliffe, D.W.: Concentrations of major ions in streams on catchments of the River Duddon (1971-1974) and Windermere (1975-1978), English Lake District. Freshwater Biological Association, Ambleside, UK, 1983 (FBA Occasional Publications 22)
    Keywords: Chemistry ; Limnology ; Calcium ; chlorides ; fresh water ; ions ; magnesium ; potassium ; seasonal variations ; sodium ; water analysis ; England ; Grasmere ; dataset
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  • 14
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    Concentrations of major ions in the stream water of the upper basin of the River Duddon, England, 1972-1974 [Dataset] (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5350 | 1256 | 2011-05-13 11:56:03 | 5350 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-10
    Description: This dataset provides raw data of chemical analyses made during studies on seasonal variations of some major ions in the stream water of the upper basin of the River Duddon in Cumbria. Measurements of sodium, calcium, potassium, magnesium and chloride ions and pH were taken at 26 stations in the River Duddon basin between 1972 and 1974.
    Description: This data was used in the publication: Carrick, T.R. & Sutcliffe, D.W.: Concentrations of Major Ions in Streams on Catchments of the River Duddon (1971-1974) and Windermere (1975-1978), English Lake District. Freshwater Biological Association, Ambleside, UK, 1983 (FBA Occasional Publications 22)
    Keywords: Chemistry ; Limnology ; Calcium ; chlorides ; fresh water ; ions ; magnesium ; potassium ; seasonal variations ; sodium ; water analysis ; England ; River Duddon ; dataset
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  • 15
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    Major ions in 25 frequently sampled tarns in the English Lake District (1954-56, 1974-1976) [Dataset] (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5353 | 1256 | 2012-07-04 19:33:33 | 5353 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-10
    Description: This dataset provides raw data of chemical analyses made during studies on seasonal variations of 25 frequently sampled tarns in Cumbria. Measurements of sodium, calcium, potassium, magnesium, pH, chloride ions, alkalinity, sulphite, strong acids and nitrate were taken between 1954 and 1956 and between 1974-1976.
    Description: This data was used in the publication: Carrick, T.R. & Sutcliffe, D.W.: Concentrations of major ions in streams on catchments of the River Duddon (1971-1974) and Windermere (1975-1978), English Lake District. Freshwater Biological Association, Ambleside, UK, 1983 (FBA Occasional Publications 22)
    Keywords: Chemistry ; Limnology ; Calcium ; chlorides ; fresh water ; ions ; magnesium ; potassium ; seasonal variations ; sodium ; water analysis ; alkalinity ; England ; Lake District ; dataset
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  • 16
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    Changes in the phytoplankton (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5111 | 3949 | 2011-09-29 15:23:22 | 5111 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-08
    Description: An article discussing changes observed in phytoplankton of the Lake District. An overview is given of previous phytoplankton studies undertaken in the area, detailing some changes found in various waterbodies. Water quality changes in Lake Windermere are mentioned, including the gradual increase of dissolved organic matter (DOM), believed to be caused by the increase of sewage to the lake. The lakes in the Alps are given as an example of a similar anthropogenic pollution scenario. The treatment of a Lake District tarn with bone meal is described. The article goes on to discuss the composition of plankton throughout the year under a variety of climatic conditions. A figure shows seasonal variation in the consistuents of phytoplankton in Windermere (north basin).
    Keywords: Biology ; Chemistry ; Limnology ; Phytoplankton ; Limnology ; Dissolved organic matter ; Seasonal variations ; Sewage ; Water quality ; Annual reports ; England ; Lake District
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  • 17
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    The chemical budget of a lake (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5107 | 3949 | 2011-09-29 15:23:50 | 5107 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-08
    Description: A progress report on research undertaken on the chemical budget of a lake, outlining the importance of nitrogen and phosphorus in governing the production of life in freshwater. The report uses the Rivers Brathay and Leven, which flow into Windermere, as examples. The report also refers to the Rivers Rothay, Troutbeck and Cunsey. A table is including which shows the monthly average nitrate content (mg per litre) of the River Brathey and River Leven for 1937 into 1938. The report also includes a figure showing Windermere lake levels, discharge and rainfall during 1937. It also briefly considers possible anthropogenic influences on water quality.
    Keywords: Chemistry ; Ecology ; Limnology ; Phosphorus ; Organic compounds ; Sewage ; Diatoms ; Algae ; Sediment chemistry ; Seasonal variations ; Annual reports ; Nitrates ; River discharge ; England
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  • 18
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    Bacteria in freshwaters (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5114 | 3949 | 2011-09-29 15:21:32 | 5114 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-08
    Description: An article looking at the numerical distribution of bacteria in lakes, the types most commonly present and the nitrogen-cycle, in Lake Windermere. The methodology is explained, including the sampling frequency and depths, and bacteria culturing techniques. Water bodies other than Lake Windermere were also sampled and these are detailed, including a water reservoir. A summary of the work into horizontal of bacteria is given, including a table showing the number of bacteria per millilitre at different distances from inflow into Windermere. A summary of the work into vertical distribution is also given, including two figures, one showing seasonal variation during 1938-9 in numbers of bacteria at different depths in Winderemere, and the other showing the relationship between the numbers of bacteria at 10 metres depth in Windermere and the rainfull during the previous 7 days. A summary of the types of bacteria found, as well as work on the nitrogen cycle in Esthwaite Water, Lake Windermere and Blelham Tarn are given.
    Keywords: Biology ; Chemistry ; Limnology ; Nitrogen cycle ; Bacteria ; Freshwater ecology ; Limnology ; Seasonal variations ; Water column ; Water reservoirs ; Annual reports ; England ; Lake District
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  • 19
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    Changes in physical and chemical variables (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5112 | 3949 | 2011-09-29 15:23:20 | 5112 | Freshwater Biological Association
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    Publication Date: 2021-07-08
    Description: An article reviewing the work undertaken looking at the seasonal variation of chemical conditions in water at various depths in lakes. The laboratory tests undertaken for the research is outlined, as well as details of the sampling locations and the staff involved with the work. One figure shows the seasonal variation in the amounts of dissolved substances in the surface water of Windermere during 1936. Another figure shows seasonal varation inthe dry weight of phyto- and zooplankton in Windermere. Seasonal changes are discussed further and a table is included showing chemical conditions in winter and summer for Windermere.
    Keywords: Biology ; Chemistry ; Limnology ; Limnology ; Chemistry ; Seasonal variations ; Diatoms ; Phytoplankton ; Zooplankton ; Water column ; Surface water ; Annual reports ; England ; Lake District
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  • 20
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    Biological surveillance of chalk-streams (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5122 | 3949 | 2011-09-29 15:22:47 | 5122 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-08
    Description: An article reviewing the methods of biological surveillance of chalk-streams developed and commonly used at that time, with a focus on their application to the River Frome catchment in Dorset. In evaluating the surveillance methods, the author looks at sampling methods (including cores and kick-sampling), the level of identification of macroinvertebrates, and temporal and spatial variations. Responses of indices to organic pollution are also discussed. A number of accompanying figures are also included.
    Keywords: Biology ; Chemistry ; Ecology ; Environment ; Chalk ; Water management ; Cores ; Aquatic communities ; Freshwater ecology ; Invertebrate larvae ; Biological surveys ; Temporal variations ; Spatial variations ; Annual reports ; England
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  • 21
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    The design and development of the Windermere Profiler. An instrument for measuring how various environmental parameters vary with depth in lakes, reservoirs and rivers (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5123 | 3949 | 2011-09-29 15:22:51 | 5123 | Freshwater Biological Association
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    Publication Date: 2021-07-08
    Description: A review article detailing the background, development and functionality of the Windermere Profiler, a multi parameter environmental monitoring instrument for use in lakes, reservoirs and rivers. The article explains the requirement for regular data collection by the Freshwater Biological Association at Windermere. The article covers the requirements of a profiling instrument, the design considerations, the electronic circuitry, the computer program, the operation of the computer software, the profiler in use and further developments to the design. A number of figures and images accompany the article.
    Keywords: Chemistry ; Environment ; Limnology ; Profilers ; Inland water environment ; Water reservoirs ; Lakes ; Rivers ; Temperature data ; Electrical conductivity ; Dissolved oxygen ; Depth measurement ; Light attenuation ; Annual reports ; England ; Lake District
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  • 22
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    The growth of brown trout (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5117 | 3949 | 2011-09-29 15:22:21 | 5117 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-08
    Description: An article discussing the factors affecting the rate of growth of brown trout, detailing the research udnertaken at Wray Castle, designed to clarify the influencing factors in different waters and investigate what would be required to increase their size. The article considers factors such as alkalinity, total hardness, the presence of coarse fish in the waterbodies and competition for food. Previous work undertaken on brown trout in Ireland by other authors is reviewed. A figure showing average growth rate of brown trout in five lakes, as determined from their scales (Lough Derg, Windermere, Loch Leven, Ullswater, Haweswater).
    Keywords: Biology ; Chemistry ; Limnology ; Coarse fish ; pH effects ; Water hardness ; Food availability ; Limnology ; England ; Lake District
    Repository Name: AquaDocs
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    Acid precipitation and its effects on aquatic systems in the English Lake District (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5189 | 3949 | 2011-09-29 15:16:49 | 5189 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: There is no evidence of an increase in the acidity (lower pH or alkalinity) of water-bodies in the Lake District over the last 50 years. Brown trout occur in acid streams and upland tarns where pH is 4.5-5.2 throughout the year. Their occurrence in such waters in Britain and Ireland has been known for most of this century and there is no previous evidence of harmful effects on salmonid fisheries, though numbers of fish are naturally low. However, many benthic invertebrates that are common in hill-streams where pH is above 5.7 do not occur in more acid streams. This phenomenon occurs in the headwaters of several western rivers in Cumbria. It is not a recent response to "acid rain". Harmful effects of pH are undoubtedly more pronounced in waters that are poor in other dissolved ions. Low concentrations of sodium, potassium, calcium and chloride are especially important and may limit the distributions of some aquatic animals even where pH is above 5.7. The concentration of sulphate ions is usually relatively high but this is not important to the fauna; concentrations are at least two times higher in productive alkaline water-bodies than they are in unproductive acid waters.
    Keywords: Chemistry ; Ecology ; Limnology ; Acid rain ; Acidification ; Alkalinity ; Freshwater pollution ; pH ; Pollution effects ; Invertebrata ; Salmonidae ; England ; Lake District ; Annual report
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    Studies of chemical speciation in naturally anoxic basins (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5181 | 3949 | 2011-09-29 15:17:17 | 5181 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: The chemical speciation of both metals and non-metals, the use of polarographic techniques, and application to the study of the chemistry of anoxic waters are considered. In the first part of the paper unfamiliar terminology is explained and then an example of simple lake chemistry is presented to illustrate why the concept of speciation is necessary.
    Keywords: Chemistry ; Limnology ; Chemical speciation ; Anoxic basins ; Annual report
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    The kinetics of calcite precipation and related processes (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5195 | 3949 | 2011-09-29 15:15:06 | 5195 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: This review is concerned with the kinetics of calcium carbonate formation and related processes which are important in many hard waters.
    Keywords: Chemistry ; Calcite ; Calcium carbonates ; Chemical precipitation ; Fresh water ; Geochemical cycle ; Annual report
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    Treading in Mortimer's footsteps: the geochemical cycling of iron and manganese in Esthwaite water (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5193 | 3949 | 2011-09-29 15:15:03 | 5193 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: A study of the geochemical cycling of iron and manganese in a seasonally stratified lake, Esthwaite water is described. This work is based on speculative ideas on environmental redox chemistry of iron which were proposed by C.H. Mortimer in the 1940's. These observations have been verified and some speculations confirmed, along with a new understanding of the manganese cycle, and detailed information on the particulate forms of both iron and manganese. Details on the mechanisms and transformations of iron have also emerged.
    Keywords: Biology ; Chemistry ; Chemical precipitation ; Freshwater lakes ; Iron ; Manganese ; Oxidation ; Redox potential ; Reduction ; Stratification ; England ; Esthwaite Lake ; Annual report
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    Long-term natural acidification of upland sites in Cumbria: Evidence from post-glacial lake sediments (2021)
    Freshwater Biological Association | Ambleside, UK
    In:  http://aquaticcommons.org/id/eprint/5197 | 3949 | 2011-09-29 15:15:33 | 5197 | Freshwater Biological Association
    Details
    Publication Date: 2021-07-09
    Description: Studies by the Freshwater Biological Association over the last 25 years have supplied data relevant to the levels of acidity in local soils and water before the onset of industrial pollution and current interest in acid rain. This article reviews published analysis from cores of lake sediments, in or near the catchment of the River Duddon. Electron spin resonance spectra of humic acids and iodine values confirm evidence from pollen analysis for a history of progressive acidification of the source material of lake sediments since before 5000 radiocarbon years, in upland catchments of the Lake District. Processes involved included: removal of basic ions from soils by rainfall, the effects of which were intensified by removal by man of deciduous forest; acidification of soils and waters by decomposition products of Calluna and further acidification of waters by Sphagnum species which colonized habitats where drainage became impeded by paludification processes.
    Keywords: Biology ; Chemistry ; Earth Sciences ; Acid rain ; Acidification ; Freshwater lakes ; Lake Basins ; Lake deposits ; pH ; Palnology ; England ; Cumbria ; Annual report
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    Psychology. Racial bias, unspoken but heard (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dovidio, John F -- New York, N.Y. -- Science. 2009 Dec 18;326(5960):1641-2. doi: 10.1126/science.1184231.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Yale University, New Haven, CT 06520-8205, USA. john.dovidio@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20019277" target="_blank"〉PubMed〈/a〉
    Keywords: *African Continental Ancestry Group ; Cues ; *European Continental Ancestry Group ; Humans ; *Nonverbal Communication ; *Prejudice ; *Social Behavior ; *Television ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Video games: a route to large-scale STEM education? (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-01-03
    Description: Video games have enormous mass appeal, reaching audiences in the hundreds of thousands to millions. They also embed many pedagogical practices known to be effective in other environments. This article reviews the sparse but encouraging data on learning outcomes for video games in science, technology, engineering, and math (STEM) disciplines, then reviews the infrastructural obstacles to wider adoption of this new medium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayo, Merrilea J -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):79-82. doi: 10.1126/science.1166900.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ewing Marion Kauffman Foundation, 4801 Rockhill Road, Kansas City, MO 64110 USA. mmayo@kauffman.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119223" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Child ; *Educational Technology/economics/standards ; Engineering/*education ; Humans ; *Learning ; *Mathematical Concepts ; Problem Solving ; Science/*education ; *Video Games/economics/standards
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Synthesizing knowledge in the classroom (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayr, Nina A -- Lo, Simon S -- Wang, Jian Z -- Yuh, William T C -- New York, N.Y. -- Science. 2009 Apr 17;324(5925):334-5. doi: 10.1126/science.324.5925.334c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19372412" target="_blank"〉PubMed〈/a〉
    Keywords: *Education, Medical, Graduate ; Humans ; Radiation Oncology/*education ; Teaching/*methods
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Epidemiology. Phone infections (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Havlin, Shlomo -- New York, N.Y. -- Science. 2009 May 22;324(5930):1023-4. doi: 10.1126/science.1174658.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physics Department, Bar-Ilan University, Ramat-Gan, 52900 Israel. havlin@ophir.ph.biu.ac.il〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19460993" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Phones ; *Computer Security ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Chemical Society fall meeting, 16-20 August, Washington, D.C. Sugary Achilles' heel raises hope for broad-acting antiviral drugs (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-09-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2009 Sep 4;325(5945):1200. doi: 10.1126/science.325_1200a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19729635" target="_blank"〉PubMed〈/a〉
    Keywords: Algal Proteins/*metabolism/*pharmacology ; Animals ; Anti-HIV Agents/metabolism/pharmacology ; Antiviral Agents/*metabolism/*pharmacology ; Ebolavirus/drug effects ; HIV/drug effects ; Humans ; Lectins/*metabolism/*pharmacology ; Mannose/*metabolism ; Mice ; Microbial Sensitivity Tests ; Plant Lectins ; SARS Virus/drug effects ; Virus Diseases/drug therapy ; Viruses/*drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The transcriptional repressor DEC2 regulates sleep length in mammals (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-15
    Description: Sleep deprivation can impair human health and performance. Habitual total sleep time and homeostatic sleep response to sleep deprivation are quantitative traits in humans. Genetic loci for these traits have been identified in model organisms, but none of these potential animal models have a corresponding human genotype and phenotype. We have identified a mutation in a transcriptional repressor (hDEC2-P385R) that is associated with a human short sleep phenotype. Activity profiles and sleep recordings of transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice in a zeitgeber time- and sleep deprivation-dependent manner. These mice represent a model of human sleep homeostasis that provides an opportunity to probe the effect of sleep on human physical and mental health.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884988/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884988/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉He, Ying -- Jones, Christopher R -- Fujiki, Nobuhiro -- Xu, Ying -- Guo, Bin -- Holder, Jimmy L Jr -- Rossner, Moritz J -- Nishino, Seiji -- Fu, Ying-Hui -- HL059596/HL/NHLBI NIH HHS/ -- MH074924/MH/NIMH NIH HHS/ -- R01 HL059596/HL/NHLBI NIH HHS/ -- R01 HL059596-09/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):866-70. doi: 10.1126/science.1174443.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, University of California at San Francisco, Mission Bay, 1550 Fourth Street, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19679812" target="_blank"〉PubMed〈/a〉
    Keywords: Activity Cycles/genetics ; Adolescent ; Adult ; Aged ; Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Animals, Genetically Modified ; Basic Helix-Loop-Helix Transcription Factors/chemistry/*genetics/physiology ; Child ; Circadian Rhythm/genetics ; Drosophila/genetics ; Electroencephalography ; Electromyography ; Female ; Homeostasis ; Humans ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Middle Aged ; Molecular Sequence Data ; Pedigree ; Point Mutation ; Sleep/*genetics/physiology ; Sleep Deprivation ; Sleep, REM/genetics/physiology ; Transcription Factors/chemistry/genetics/physiology ; Wakefulness
    Print ISSN: 0036-8075
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    Influenza: accounting for prior immunity (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCaw, James M -- McVernon, Jodie -- McBryde, Emma S -- Mathews, John D -- New York, N.Y. -- Science. 2009 Aug 28;325(5944):1071; author reply 1072-3. doi: 10.1126/science.325_1071a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19713508" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Disease Susceptibility ; Humans ; Immunity ; *Influenza A Virus, H1N1 Subtype/immunology ; Influenza, Human/*epidemiology/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A new wave of chemical regulations just ahead? (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2009 Aug 7;325(5941):692-3. doi: 10.1126/science.325_692.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19661413" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Industry/*legislation & jurisprudence ; *Government Regulation ; *Hazardous Substances ; Humans ; Legislation as Topic ; Toxicity Tests ; United States ; United States Environmental Protection Agency/*legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    On becoming a scientist (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2009 Nov 13;326(5955):916. doi: 10.1126/science.1184202.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965482" target="_blank"〉PubMed〈/a〉
    Keywords: *Education, Graduate ; Humans ; *Mentors ; *Research/education ; Research Personnel/*education ; Science/*education
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Immunology. Two-in-one designer antibodies (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parren, Paul W H I -- Burton, Dennis R -- New York, N.Y. -- Science. 2009 Mar 20;323(5921):1567-8. doi: 10.1126/science.1172253.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands. p.parren@genmab.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19299606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Bispecific/chemistry/*immunology/therapeutic use ; Antibodies, Monoclonal/chemistry/genetics/*immunology/therapeutic use ; Antibodies, Monoclonal, Humanized ; Antibody Affinity ; Antibody Specificity ; Binding Sites, Antibody ; Crystallography, X-Ray ; Epitopes ; Genetic Engineering ; Humans ; Neoplasms, Experimental/drug therapy ; Receptor, ErbB-2/*immunology ; Trastuzumab ; Vascular Endothelial Growth Factor A/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Local DNA topography correlates with functional noncoding regions of the human genome (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-17
    Description: The three-dimensional molecular structure of DNA, specifically the shape of the backbone and grooves of genomic DNA, can be dramatically affected by nucleotide changes, which can cause differences in protein-binding affinity and phenotype. We developed an algorithm to measure constraint on the basis of similarity of DNA topography among multiple species, using hydroxyl radical cleavage patterns to interrogate the solvent-accessible surface area of DNA. This algorithm found that 12% of bases in the human genome are evolutionarily constrained-double the number detected by nucleotide sequence-based algorithms. Topography-informed constrained regions correlated with functional noncoding elements, including enhancers, better than did regions identified solely on the basis of nucleotide sequence. These results support the idea that the molecular shape of DNA is under selection and can identify evolutionary history.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749491/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749491/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parker, Stephen C J -- Hansen, Loren -- Abaan, Hatice Ozel -- Tullius, Thomas D -- Margulies, Elliott H -- R01 HG003541/HG/NHGRI NIH HHS/ -- R01 HG003541-03/HG/NHGRI NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2009 Apr 17;324(5925):389-92. doi: 10.1126/science.1169050. Epub 2009 Mar 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bioinformatics Program, Boston University, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19286520" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Amino Acid Motifs ; Base Sequence ; Binding Sites ; Conserved Sequence ; DNA/*chemistry/genetics ; Deoxyribonuclease I/metabolism ; Early Growth Response Protein 1/genetics/metabolism ; Evolution, Molecular ; *Genome, Human ; Humans ; Mutant Proteins/metabolism ; Nucleic Acid Conformation ; Phenotype ; Polymorphism, Single Nucleotide ; Selection, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Behavior. Monkeys like mimics (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Call, Josep -- Carpenter, Malinda -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):824-5. doi: 10.1126/science.1178714.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany. call@eva.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19679802" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cebus/*psychology ; Humans ; *Imitative Behavior ; *Social Behavior
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Comment on "Human-specific gain of function in a developmental enhancer" (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-07
    Description: Prabhakar et al. (Reports, 5 September 2008, p. 1346) argued that the conserved noncoding sequence HACNS1 has undergone positive selection and contributed to human adaptation. However, the pattern of substitution in HACNS1 is more consistent with the neutral process of biased gene conversion (BGC). The reported human-specific gain of function is likely due to the accumulation of deleterious mutations driven by BGC, not positive selection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duret, Laurent -- Galtier, Nicolas -- New York, N.Y. -- Science. 2009 Feb 6;323(5915):714; author reply 714. doi: 10.1126/science.1165848.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Universite de Lyon, Universite Lyon 1, CNRS, UMR5558, Laboratoire de Biometrie et Biologie Evolutive, F-69622, Villeurbanne, France. duret@biomserv.univ-lyon1.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19197042" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Conserved Sequence ; *Enhancer Elements, Genetic ; Evolution, Molecular ; *Gene Conversion ; Humans ; Mutation ; Recombination, Genetic ; Selection, Genetic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Climate change. Clean air for megacities (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-11-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parrish, David D -- Zhu, Tong -- New York, N.Y. -- Science. 2009 Oct 30;326(5953):674-5. doi: 10.1126/science.1176064.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Chemical Sciences Division, Earth System Research Laboratory, National Oceanic and Atmospheric Administration, Boulder, CO 80305, USA. david.d.parrish@noaa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19900921" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollution/adverse effects ; *Cities ; *Climate Change ; Humans ; Particulate Matter ; Population Density
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The art of translation (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-10-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2009 Oct 9;326(5950):205. doi: 10.1126/science.1182658.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19815740" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Clinical Medicine ; Diffusion of Innovation ; Humans ; *Interdisciplinary Communication ; *Periodicals as Topic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Restoration of ecosystem services for environmental markets (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-01
    Description: Ecological restoration is an activity that ideally results in the return of an ecosystem to an undisturbed state. Ecosystem services are the benefits humans derive from ecosystems. The two have been joined to support growing environmental markets with the goal of creating restoration-based credits that can be bought and sold. However, the allure of these markets may be overshadowing shortcomings in the science and practice of ecological restoration. Before making risky investments, we must understand why and when restoration efforts fall short of recovering the full suite of ecosystem services, what can be done to improve restoration success, and why direct measurement of the biophysical processes that support ecosystem services is the only way to guarantee the future success of these markets. Without new science and an oversight framework to protect the ecosystem service assets which people depend, markets could actually accelerate environmental degradation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palmer, Margaret A -- Filoso, Solange -- New York, N.Y. -- Science. 2009 Jul 31;325(5940):575-6. doi: 10.1126/science.1172976.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, MD 20688, USA. mpalmer@umd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19644112" target="_blank"〉PubMed〈/a〉
    Keywords: Biodiversity ; Biophysical Processes ; *Conservation of Natural Resources ; *Ecosystem ; *Environment ; Humans ; Wetlands
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Online education today (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-01-03
    Description: Online education is established, growing, and here to stay. It is creating new opportunities for students and also for faculty, regulators of education, and the educational institutions themselves. Much of what is being learned by the practitioners will flow into the large numbers of blended courses that will be developed and delivered on most campuses. Some of what is being learned will certainly improve pedagogical approaches and possibly affect other important problems, such as the lengthening time to completion of a degree. Online education is already providing better access to education for many, and many more will benefit from this increased access in the coming years.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayadas, A Frank -- Bourne, John -- Bacsich, Paul -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):85-9. doi: 10.1126/science.1168874.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Alfred P. Sloan Foundation, 630 Fifth Avenue, New York, NY 10111, USA. mayadas@sloan.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119225" target="_blank"〉PubMed〈/a〉
    Keywords: Computer-Assisted Instruction/economics ; *Education, Distance/economics ; Faculty ; Federal Government ; Humans ; *Internet ; Online Systems ; State Government ; Students ; Training Support ; United States ; *Universities
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Redefining cancer research (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-09-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- New York, N.Y. -- Science. 2009 Sep 11;325(5946):1319. doi: 10.1126/science.1181224.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19745119" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antineoplastic Agents/pharmacology/therapeutic use ; *Biomedical Research ; DNA Repair ; Drug Discovery ; Humans ; Mutation ; *Neoplasms/drug therapy/genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 46
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    Comment on "Log or linear? Distinct intuitions of the number scale in Western and Amazonian indigene cultures" (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-01-03
    Description: Dehaene et al. (Reports, 30 May 2008, p. 1217) argued that native speakers of Mundurucu, a language without a linguistic numerical system, inherently represent numerical values as a logarithmically spaced spatial continuum. However, their data do not rule out the alternative conclusion that Mundurucu speakers encode numbers linearly with scalar variability and psychologically construct space-number mappings by analogy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393850/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393850/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cantlon, Jessica F -- Cordes, Sara -- Libertus, Melissa E -- Brannon, Elizabeth M -- R37 HD023103/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):38; author reply 38. doi: 10.1126/science.1164773.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA. jfc2@duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119201" target="_blank"〉PubMed〈/a〉
    Keywords: Brazil ; Humans ; *Indians, South American ; *Intuition ; *Language ; *Mathematical Concepts
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Influenza: H1N1 goes to school (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paterson, Bev -- Durrheim, David N -- Tuyl, Frank -- New York, N.Y. -- Science. 2009 Aug 28;325(5944):1071-2; author reply 1072-3. doi: 10.1126/science.325_1071b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19713507" target="_blank"〉PubMed〈/a〉
    Keywords: *Disease Outbreaks ; Humans ; *Influenza A Virus, H1N1 Subtype ; Influenza, Human/*epidemiology/*transmission ; *Schools ; United States/epidemiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Haploid genetic screens in human cells identify host factors used by pathogens (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-08
    Description: Loss-of-function genetic screens in model organisms have elucidated numerous biological processes, but the diploid genome of mammalian cells has precluded large-scale gene disruption. We used insertional mutagenesis to develop a screening method to generate null alleles in a human cell line haploid for all chromosomes except chromosome 8. Using this approach, we identified host factors essential for infection with influenza and genes encoding important elements of the biosynthetic pathway of diphthamide, which are required for the cytotoxic effects of diphtheria toxin and exotoxin A. We also identified genes needed for the action of cytolethal distending toxin, including a cell-surface protein that interacts with the toxin. This approach has both conceptual and practical parallels with genetic approaches in haploid yeast.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carette, Jan E -- Guimaraes, Carla P -- Varadarajan, Malini -- Park, Annie S -- Wuethrich, Irene -- Godarova, Alzbeta -- Kotecki, Maciej -- Cochran, Brent H -- Spooner, Eric -- Ploegh, Hidde L -- Brummelkamp, Thijn R -- New York, N.Y. -- Science. 2009 Nov 27;326(5957):1231-5. doi: 10.1126/science.1178955.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965467" target="_blank"〉PubMed〈/a〉
    Keywords: ADP Ribose Transferases/metabolism/toxicity ; Adenosine Diphosphate Ribose/metabolism ; Amino Acid Sequence ; Antigens, Bacterial/metabolism/toxicity ; Bacterial Toxins/*metabolism/toxicity ; Biosynthetic Pathways ; Cell Line, Tumor ; Diphtheria Toxin/metabolism/toxicity ; Exotoxins/metabolism/toxicity ; Genes ; *Genetic Testing ; *Haploidy ; Histidine/analogs & derivatives/biosynthesis ; *Host-Pathogen Interactions ; Humans ; Influenza A Virus, H1N1 Subtype/*pathogenicity ; Molecular Sequence Data ; Monosaccharide Transport Proteins/genetics/metabolism ; Mutagenesis, Insertional ; N-Acylneuraminate Cytidylyltransferase/genetics/metabolism ; Peptide Elongation Factor 2/metabolism ; Proteins/chemistry/genetics/metabolism ; Virulence Factors/metabolism/toxicity
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Flexible learning of multiple speech structures in bilingual infants (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-11
    Description: Children acquire their native language according to a well-defined time frame. Surprisingly, although children raised in bilingual environments have to learn roughly twice as much about language as their monolingual peers, the speed of acquisition is comparable in monolinguals and bilinguals. Here, we show that preverbal 12-month-old bilingual infants have become more flexible at learning speech structures than monolinguals. When given the opportunity to simultaneously learn two different regularities, bilingual infants learned both, whereas monolinguals learned only one of them. Hence, bilinguals may acquire two languages in the time in which monolinguals acquire one because they quickly become more flexible learners.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kovacs, Agnes Melinda -- Mehler, Jacques -- New York, N.Y. -- Science. 2009 Jul 31;325(5940):611-2. doi: 10.1126/science.1173947. Epub 2009 Jul 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scuola Internazionale Superiore di Studi Avanzati-SISSA, Via Beirut 4, 34014 Trieste, Italy. agneskovacs@mtapi.hu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19589962" target="_blank"〉PubMed〈/a〉
    Keywords: *Child Language ; Female ; Humans ; Infant ; *Language Development ; *Learning ; Male ; *Multilingualism ; *Speech Perception
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Infectious diseases. Farm fungicides linked to resistance in a human pathogen (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2009 Nov 27;326(5957):1173. doi: 10.1126/science.326.5957.1173.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965440" target="_blank"〉PubMed〈/a〉
    Keywords: *Agrochemicals/chemistry/pharmacology ; Antifungal Agents/chemistry/*pharmacology/therapeutic use ; Aspergillosis/drug therapy/*microbiology ; Aspergillus fumigatus/*drug effects/genetics ; Azoles/chemistry/pharmacology ; Cytochrome P-450 Enzyme System/genetics ; *Drug Resistance, Fungal ; Europe ; Fungal Proteins/genetics ; *Fungicides, Industrial/chemistry/pharmacology ; Humans ; Point Mutation ; Pulmonary Aspergillosis/drug therapy/*microbiology ; Soil Microbiology ; Tandem Repeat Sequences
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    Mozambican grass seed consumption during the Middle Stone Age (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-19
    Description: The role of starchy plants in early hominin diets and when the culinary processing of starches began have been difficult to track archaeologically. Seed collecting is conventionally perceived to have been an irrelevant activity among the Pleistocene foragers of southern Africa, on the grounds of both technological difficulty in the processing of grains and the belief that roots, fruits, and nuts, not cereals, were the basis for subsistence for the past 100,000 years and further back in time. A large assemblage of starch granules has been retrieved from the surfaces of Middle Stone Age stone tools from Mozambique, showing that early Homo sapiens relied on grass seeds starting at least 105,000 years ago, including those of sorghum grasses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercader, Julio -- New York, N.Y. -- Science. 2009 Dec 18;326(5960):1680-3. doi: 10.1126/science.1173966.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Archaeology, University of Calgary, Alberta, T2N 1N4, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20019285" target="_blank"〉PubMed〈/a〉
    Keywords: *Archaeology ; Diet ; Edible Grain/*history ; History, Ancient ; Humans ; Mozambique ; *Poaceae ; *Seeds ; *Sorghum ; Starch
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    Orc1 controls centriole and centrosome copy number in human cells (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-07
    Description: Centrosomes, each containing a pair of centrioles, organize microtubules in animal cells, particularly during mitosis. DNA and centrosomes are normally duplicated once before cell division to maintain optimal genome integrity. We report a new role for the Orc1 protein, a subunit of the origin recognition complex (ORC) that is a key component of the DNA replication licensing machinery, in controlling centriole and centrosome copy number in human cells, independent of its role in DNA replication. Cyclin A promotes Orc1 localization to centrosomes where Orc1 prevents Cyclin E-dependent reduplication of both centrioles and centrosomes in a single cell division cycle. The data suggest that Orc1 is a regulator of centriole and centrosome reduplication as well as the initiation of DNA replication.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653626/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653626/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hemerly, Adriana S -- Prasanth, Supriya G -- Siddiqui, Khalid -- Stillman, Bruce -- CA13106/CA/NCI NIH HHS/ -- P01 CA013106/CA/NCI NIH HHS/ -- P01 CA013106-310025/CA/NCI NIH HHS/ -- P01 CA013106-36/CA/NCI NIH HHS/ -- P01 CA013106-370025/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2009 Feb 6;323(5915):789-93. doi: 10.1126/science.1166745.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor 11724, NY, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19197067" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Cycle ; Cell Line, Tumor ; Centrioles/*physiology ; Centrosome/*physiology ; Cyclin A/metabolism ; Cyclin E/metabolism ; Cyclin-Dependent Kinase 2/metabolism ; DNA Replication ; HeLa Cells ; Humans ; Kinetics ; Mutant Proteins/metabolism ; Origin Recognition Complex/genetics/*metabolism ; RNA Interference ; RNA, Small Interfering ; Transfection
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Recruitment of an area involved in eye movements during mental arithmetic (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-09
    Description: Throughout the history of mathematics, concepts of number and space have been tightly intertwined. We tested the hypothesis that cortical circuits for spatial attention contribute to mental arithmetic in humans. We trained a multivariate classifier algorithm to infer the direction of an eye movement, left or right, from the brain activation measured in the posterior parietal cortex. Without further training, the classifier then generalized to an arithmetic task. Its left versus right classification could be used to sort out subtraction versus addition trials, whether performed with symbols or with sets of dots. These findings are consistent with the suggestion that mental arithmetic co-opts parietal circuitry associated with spatial coding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knops, Andre -- Thirion, Bertrand -- Hubbard, Edward M -- Michel, Vincent -- Dehaene, Stanislas -- New York, N.Y. -- Science. 2009 Jun 19;324(5934):1583-5. doi: 10.1126/science.1171599. Epub 2009 May 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM, Cognitive Neuroimaging Unit, F-91191 Gif-sur-Yvette, France. knops.andre@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19423779" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Eye Movements/*physiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; *Mathematics ; Mental Processes/*physiology ; Parietal Lobe/*physiology ; Recruitment, Neurophysiological
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    Platelets kill intraerythrocytic malarial parasites and mediate survival to infection (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-07
    Description: Platelets play a critical role in the pathogenesis of malarial infections by encouraging the sequestration of infected red blood cells within the cerebral vasculature. But platelets also have well-established roles in innate protection against microbial infections. We found that purified human platelets killed Plasmodium falciparum parasites cultured in red blood cells. Inhibition of platelet function by aspirin and other platelet inhibitors abrogated the lethal effect human platelets exert on P. falciparum parasites. Likewise, platelet-deficient and aspirin-treated mice were more susceptible to death during erythrocytic infection with Plasmodium chabaudi. Both mouse and human platelets bind malarial-infected red cells and kill the parasite within. These results indicate a protective function for platelets in the early stages of erythrocytic infection distinct from their role in cerebral malaria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McMorran, Brendan J -- Marshall, Vikki M -- de Graaf, Carolyn -- Drysdale, Karen E -- Shabbar, Meriam -- Smyth, Gordon K -- Corbin, Jason E -- Alexander, Warren S -- Foote, Simon J -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2009 Feb 6;323(5915):797-800. doi: 10.1126/science.1166296.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia. brendan.mcmorran@utas.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19197068" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/metabolism ; Animals ; Aspirin/pharmacology ; Blood Platelets/metabolism/*physiology ; Erythrocytes/*parasitology ; Female ; Humans ; In Situ Nick-End Labeling ; Malaria/*blood/immunology/*parasitology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Plasmodium chabaudi/*growth & development ; Plasmodium falciparum/*growth & development ; Platelet Activation ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Count ; Receptors, Purinergic P2/metabolism ; Receptors, Purinergic P2Y1 ; Receptors, Thrombopoietin/genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Diplomacy. U.S. takes steps to use science to improve ties to Muslim world (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, Robert -- New York, N.Y. -- Science. 2009 Nov 13;326(5955):920-1. doi: 10.1126/science.326.5955.920.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965483" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *International Cooperation ; *Islam ; Middle East ; *Science ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Paleontology. Fire and stone (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Webb, John -- Domanski, Marian -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):820-1. doi: 10.1126/science.1178014.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Environmental Geoscience, La Trobe University, Victoria 3086, Australia. John.Webb@latrobe.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19679799" target="_blank"〉PubMed〈/a〉
    Keywords: *Archaeology ; *Fires ; History, Ancient ; *Hot Temperature ; Humans ; Paleontology ; South Africa ; Technology/*history
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Scientific publishing. Paper retracted following genome data breach (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Sep 18;325(5947):1486-7. doi: 10.1126/science.325_1486a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19762616" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; *Databases, Genetic ; Female ; Homeodomain Proteins/genetics ; Humans ; *National Institutes of Health (U.S.) ; Publishing/*standards ; *Retraction of Publication as Topic ; Substance-Related Disorders/genetics ; Transcription Factors/genetics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Out with the old, in with the new? (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pedersen, Roger -- G0300723/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2009 Jun 26;324(5935):1617. doi: 10.1126/science.1177267.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19556472" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics/ethics ; Embryo Research/*economics/ethics ; *Embryonic Stem Cells ; Financing, Government ; Guidelines as Topic ; Humans ; Informed Consent ; National Institutes of Health (U.S.) ; *Pluripotent Stem Cells ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Certificates should be retired (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hermos, John A -- Spiro, Avron 3rd -- New York, N.Y. -- Science. 2009 Mar 6;323(5919):1288-9. doi: 10.1126/science.323.5919.1288c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19265002" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*ethics/legislation & jurisprudence ; *Confidentiality/ethics/legislation & jurisprudence ; *Disclosure/ethics/legislation & jurisprudence ; Humans ; Informed Consent ; Jurisprudence ; National Institutes of Health (U.S.) ; *Research Subjects/legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. higher education. Minority retention rates in science are sore spot for most universities (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, Robert -- New York, N.Y. -- Science. 2009 Jun 12;324(5933):1386-7. doi: 10.1126/science.324_1386a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19520937" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Science Disciplines/*education ; California ; Humans ; Maryland ; Mentors ; Minority Groups/*education ; Program Evaluation ; Science/*education ; *Students ; United States ; *Universities/economics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Epidemiology. Does viral diversity matter? (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Medley, Graham F -- Nokes, D James -- 061584/Wellcome Trust/United Kingdom -- 076278/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2009 Jul 17;325(5938):274-5. doi: 10.1126/science.1177475.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK. graham.medley@warwick.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19608903" target="_blank"〉PubMed〈/a〉
    Keywords: *Antigenic Variation ; Birth Rate ; Child ; Developing Countries ; *Disease Outbreaks ; Endemic Diseases ; *Genetic Variation ; Humans ; Mass Vaccination ; Prevalence ; Respiratory Syncytial Virus Infections/epidemiology/immunology/prevention & ; control/virology ; Respiratory Syncytial Viruses/genetics/immunology ; Rotavirus/*genetics/immunology ; Rotavirus Infections/*epidemiology/immunology/prevention & control/*virology ; *Rotavirus Vaccines/administration & dosage/immunology ; Viral Vaccines/administration & dosage/immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Motile cilia of human airway epithelia are chemosensory (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-25
    Description: Cilia are microscopic projections that extend from eukaryotic cells. There are two general types of cilia; primary cilia serve as sensory organelles, whereas motile cilia exert mechanical force. The motile cilia emerging from human airway epithelial cells propel harmful inhaled material out of the lung. We found that these cells express sensory bitter taste receptors, which localized on motile cilia. Bitter compounds increased the intracellular calcium ion concentration and stimulated ciliary beat frequency. Thus, airway epithelia contain a cell-autonomous system in which motile cilia both sense noxious substances entering airways and initiate a defensive mechanical mechanism to eliminate the offending compound. Hence, like primary cilia, classical motile cilia also contain sensors to detect the external environment.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894709/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894709/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shah, Alok S -- Ben-Shahar, Yehuda -- Moninger, Thomas O -- Kline, Joel N -- Welsh, Michael J -- DK54759/DK/NIDDK NIH HHS/ -- HL51670/HL/NHLBI NIH HHS/ -- P01 HL051670/HL/NHLBI NIH HHS/ -- P01 HL051670-15/HL/NHLBI NIH HHS/ -- P30 DK054759/DK/NIDDK NIH HHS/ -- P30 DK054759-109004/DK/NIDDK NIH HHS/ -- P30 DK054759-13/DK/NIDDK NIH HHS/ -- R01 DK051315/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2009 Aug 28;325(5944):1131-4. doi: 10.1126/science.1173869. Epub 2009 Jul 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19628819" target="_blank"〉PubMed〈/a〉
    Keywords: Bronchi/cytology ; Calcium/metabolism ; Cells, Cultured ; Cilia/metabolism/*physiology ; Epithelial Cells/*metabolism ; Humans ; Monoterpenes/metabolism/pharmacology ; Movement ; Noxae ; Phospholipase C beta/metabolism ; Quaternary Ammonium Compounds/metabolism/pharmacology ; Receptors, G-Protein-Coupled/*metabolism ; Respiratory Mucosa/cytology/*metabolism ; *Signal Transduction ; *Taste ; Trachea/cytology ; Transducin/metabolism
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    Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-11-07
    Description: X-linked adrenoleukodystrophy (ALD) is a severe brain demyelinating disease in boys that is caused by a deficiency in ALD protein, an adenosine triphosphate-binding cassette transporter encoded by the ABCD1 gene. ALD progression can be halted by allogeneic hematopoietic cell transplantation (HCT). We initiated a gene therapy trial in two ALD patients for whom there were no matched donors. Autologous CD34+ cells were removed from the patients, genetically corrected ex vivo with a lentiviral vector encoding wild-type ABCD1, and then re-infused into the patients after they had received myeloablative treatment. Over a span of 24 to 30 months of follow-up, we detected polyclonal reconstitution, with 9 to 14% of granulocytes, monocytes, and T and B lymphocytes expressing the ALD protein. These results strongly suggest that hematopoietic stem cells were transduced in the patients. Beginning 14 to 16 months after infusion of the genetically corrected cells, progressive cerebral demyelination in the two patients stopped, a clinical outcome comparable to that achieved by allogeneic HCT. Thus, lentiviral-mediated gene therapy of hematopoietic stem cells can provide clinical benefits in ALD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cartier, Nathalie -- Hacein-Bey-Abina, Salima -- Bartholomae, Cynthia C -- Veres, Gabor -- Schmidt, Manfred -- Kutschera, Ina -- Vidaud, Michel -- Abel, Ulrich -- Dal-Cortivo, Liliane -- Caccavelli, Laure -- Mahlaoui, Nizar -- Kiermer, Veronique -- Mittelstaedt, Denice -- Bellesme, Celine -- Lahlou, Najiba -- Lefrere, Francois -- Blanche, Stephane -- Audit, Muriel -- Payen, Emmanuel -- Leboulch, Philippe -- l'Homme, Bruno -- Bougneres, Pierre -- Von Kalle, Christof -- Fischer, Alain -- Cavazzana-Calvo, Marina -- Aubourg, Patrick -- New York, N.Y. -- Science. 2009 Nov 6;326(5954):818-23. doi: 10.1126/science.1171242.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM UMR745, University Paris-Descartes, 75279 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19892975" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/*genetics ; Adrenoleukodystrophy/genetics/pathology/*therapy ; Animals ; Brain/pathology ; Cell Differentiation ; Cell Lineage ; Child ; Disease Progression ; Fatty Acids/blood ; Female ; Gene Expression ; *Genetic Therapy ; *Genetic Vectors ; HIV-1/*genetics ; Hematopoiesis ; *Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/*physiology/virology ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Mice ; Microglia/cytology/metabolism ; Myeloablative Agonists/therapeutic use ; Transduction, Genetic ; Transplantation Conditioning ; Transplantation, Autologous ; Virus Integration
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    Direct evidence for spinal cord involvement in placebo analgesia (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-10-17
    Description: Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging of the human spinal cord to test the hypothesis that placebo analgesia results in a reduction of nociceptive processing in the spinal cord. In line with behavioral data that show decreased pain responses under placebo, pain-related activity in the spinal cord is strongly reduced under placebo. These results provide direct evidence for spinal inhibition as one mechanism of placebo analgesia and highlight that psychological factors can act on the earliest stages of pain processing in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eippert, Falk -- Finsterbusch, Jurgen -- Bingel, Ulrike -- Buchel, Christian -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):404. doi: 10.1126/science.1180142.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. f.eippert@uke.uni-hamburg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833962" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Analgesia/*psychology ; Analgesics/therapeutic use ; Humans ; Lidocaine/therapeutic use ; Magnetic Resonance Imaging ; Male ; Pain/drug therapy/*psychology ; Pain Measurement ; Pain Threshold ; *Placebo Effect ; Placebos/*therapeutic use ; Posterior Horn Cells/physiology ; Spinal Cord/*physiology ; Young Adult
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    Biomedical research. Researchers generally happy with final stem cell rules (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Jul 10;325(5937):131. doi: 10.1126/science.325_131.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19589969" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; *Embryo Research/economics ; *Embryonic Stem Cells ; Financing, Government ; *Guidelines as Topic ; Humans ; National Institutes of Health (U.S.) ; Registries ; *Research Support as Topic ; United States
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    Profile: Ruth Ley. Gut reactions (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2009 May 29;324(5931):1136-7. doi: 10.1126/science.324_1136.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19478161" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/classification/genetics/*isolation & purification ; Diet ; Digestive System/*microbiology ; Ecology/history ; Genes ; Genes, Bacterial ; Genomics/history ; History, 20th Century ; History, 21st Century ; Humans ; Interdisciplinary Communication ; *Metagenome ; *Microbiology/history ; United States
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    Education. Science needs kids with vision (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-09-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Sep 4;325(5945):1190-1. doi: 10.1126/science.325_1190b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19729624" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Aptitude Tests ; Child ; *Child, Gifted ; *Cognition ; Female ; Humans ; Male ; Sex Characteristics ; *Space Perception
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    Optimizing influenza vaccine distribution (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-22
    Description: The criteria to assess public health policies are fundamental to policy optimization. Using a model parametrized with survey-based contact data and mortality data from influenza pandemics, we determined optimal vaccine allocation for five outcome measures: deaths, infections, years of life lost, contingent valuation, and economic costs. We find that optimal vaccination is achieved by prioritization of schoolchildren and adults aged 30 to 39 years. Schoolchildren are most responsible for transmission, and their parents serve as bridges to the rest of the population. Our results indicate that consideration of age-specific transmission dynamics is paramount to the optimal allocation of influenza vaccines. We also found that previous and new recommendations from the U.S. Centers for Disease Control and Prevention both for the novel swine-origin influenza and, particularly, for seasonal influenza, are suboptimal for all outcome measures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Medlock, Jan -- Galvani, Alison P -- New York, N.Y. -- Science. 2009 Sep 25;325(5948):1705-8. doi: 10.1126/science.1175570. Epub 2009 Aug 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520-8034, USA. medlock@clemson.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19696313" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Aged ; Centers for Disease Control and Prevention (U.S.) ; Child ; Child, Preschool ; Disease Outbreaks/*prevention & control ; Health Policy ; Humans ; *Immunization Programs ; Infant ; Influenza A Virus, H1N1 Subtype/immunology ; *Influenza A virus/immunology ; Influenza Vaccines/*administration & dosage/*supply & distribution ; Influenza, Human/epidemiology/mortality/*prevention & control/transmission ; Middle Aged ; Models, Statistical ; United States/epidemiology ; Vaccination ; Young Adult
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Protecting the herd from H1N1 (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eisenberg, Joseph N S -- Aiello, Allison E -- Spicknall, Ian H -- Monto, Arnold S -- Reingold, Arthur -- New York, N.Y. -- Science. 2009 Nov 13;326(5955):934; author reply 934. doi: 10.1126/science.326.5955.934-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965495" target="_blank"〉PubMed〈/a〉
    Keywords: Centers for Disease Control and Prevention (U.S.) ; Child ; Disease Susceptibility ; Humans ; *Immunity, Herd ; Influenza A Virus, H1N1 Subtype/*immunology ; Influenza Vaccines/*administration & dosage ; Influenza, Human/*prevention & control/transmission ; *Mass Vaccination ; Risk ; United States/epidemiology
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    Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-17
    Description: Once all chromosomes are connected to the mitotic spindle (bioriented), anaphase is initiated by the protein ubiquitylation activity of the anaphase-promoting complex/cyclosome (APC/C) and its coactivator Cdc20 (APC/C(Cdc20)). Before chromosome biorientation, anaphase is delayed by a mitotic checkpoint complex (MCC) that inhibits APC/C(Cdc20). We used single-particle electron microscopy to obtain three-dimensional models of human APC/C in various functional states: bound to MCC, to Cdc20, or to neither (apo-APC/C). These experiments revealed that MCC associates with the Cdc20 binding site on APC/C, locks the otherwise flexible APC/C in a "closed" state, and prevents binding and ubiquitylation of a wide range of different APC/C substrates. These observations clarify the structural basis for the inhibition of APC/C by spindle checkpoint proteins.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989460/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989460/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herzog, Franz -- Primorac, Ivana -- Dube, Prakash -- Lenart, Peter -- Sander, Bjorn -- Mechtler, Karl -- Stark, Holger -- Peters, Jan-Michael -- F 3407/Austrian Science Fund FWF/Austria -- New York, N.Y. -- Science. 2009 Mar 13;323(5920):1477-81. doi: 10.1126/science.1163300.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19286556" target="_blank"〉PubMed〈/a〉
    Keywords: Anaphase ; Anaphase-Promoting Complex-Cyclosome ; Cdc20 Proteins ; Cell Cycle Proteins/chemistry/metabolism ; HeLa Cells ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Microscopy, Electron ; *Mitosis ; Models, Molecular ; Protein Binding ; Protein Conformation ; Protein Structure, Tertiary ; Spindle Apparatus/*metabolism ; Ubiquitin-Conjugating Enzymes/chemistry/metabolism ; Ubiquitin-Protein Ligase Complexes/*chemistry/*metabolism ; Ubiquitination
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Mayas live on (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pena-Castro, Julian M -- New York, N.Y. -- Science. 2009 Jul 31;325(5940):536. doi: 10.1126/science.325_536a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19644091" target="_blank"〉PubMed〈/a〉
    Keywords: *Culture ; Humans ; *Indians, Central American
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Drug resistance. A 'wimpy' flu strain mysteriously turns scary (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2009 Feb 27;323(5918):1162-3. doi: 10.1126/science.323.5918.1162.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19251605" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; Antiviral Agents/*pharmacology/therapeutic use ; *Drug Resistance, Viral ; Enzyme Inhibitors/pharmacology/therapeutic use ; Evolution, Molecular ; Humans ; Influenza A Virus, H1N1 Subtype/*drug effects/genetics ; Influenza, Human/drug therapy/virology ; *Mutation ; Neuraminidase/antagonists & inhibitors/chemistry/*genetics ; Oseltamivir/*pharmacology/therapeutic use
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Predicting elections: child's play! (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-03
    Description: In two experiments, children and adults rated pairs of faces from election races. Naive adults judged a pair on competence; after playing a game, children chose who they would prefer to be captain of their boat. Children's (as well as adults') preferences accurately predicted actual election outcomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Antonakis, John -- Dalgas, Olaf -- New York, N.Y. -- Science. 2009 Feb 27;323(5918):1183. doi: 10.1126/science.1167748.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Faculty of Business and Economics, University of Lausanne, 1015 Lausanne, Switzerland. john.antonakis@unil.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19251621" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; *Choice Behavior ; *Face ; Female ; Forecasting ; Games, Experimental ; Humans ; Male ; Middle Aged ; Physiognomy ; *Politics ; Probability ; Regression Analysis ; Young Adult
    Print ISSN: 0036-8075
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    Biomedical research. Hughes backs institute at epicenter of HIV and resistant TB (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, Robert -- New York, N.Y. -- Science. 2009 Mar 27;323(5922):1659. doi: 10.1126/science.323.5922.1659.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325090" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics ; *HIV Infections/complications/epidemiology/immunology ; Humans ; Mycobacterium tuberculosis/drug effects/pathogenicity ; Research Support as Topic ; South Africa/epidemiology ; *Tuberculosis, ; Multidrug-Resistant/complications/diagnosis/epidemiology/immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Global health. Some neglected diseases are more neglected than others (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2009 Feb 6;323(5915):700. doi: 10.1126/science.323.5915.700.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19197032" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Financing, Government ; *Global Health ; Humans ; *Infection/epidemiology ; *Research Support as Topic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The subtle transmission of race bias via televised nonverbal behavior (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-19
    Description: Compared with more explicit racial slurs and statements, biased facial expressions and body language may resist conscious identification and thus produce a hidden social influence. In four studies, we show that race biases can be subtly transmitted via televised nonverbal behavior. Characters on 11 popular television shows exhibited more negative nonverbal behavior toward black than toward status-matched white characters. Critically, exposure to prowhite (versus problack) nonverbal bias increased viewers' bias even though patterns of nonverbal behavior could not be consciously reported. These findings suggest that hidden patterns of televised nonverbal behavior influence bias among viewers.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764987/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764987/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weisbuch, Max -- Pauker, Kristin -- Ambady, Nalini -- F32 MH078350/MH/NIMH NIH HHS/ -- F32MH078350/MH/NIMH NIH HHS/ -- R01 MH070833/MH/NIMH NIH HHS/ -- R01 MH070833-02/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2009 Dec 18;326(5960):1711-4. doi: 10.1126/science.1178358.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA. max.weisbuch@tufts.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20019288" target="_blank"〉PubMed〈/a〉
    Keywords: *African Continental Ancestry Group ; Cues ; *European Continental Ancestry Group ; Facial Expression ; Female ; Humans ; Kinesics ; Male ; *Nonverbal Communication ; *Prejudice ; *Television ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Evolutionary medicine. Darwin applies to medical school (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2009 Apr 10;324(5924):162-3. doi: 10.1126/science.324.5924.162a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19359553" target="_blank"〉PubMed〈/a〉
    Keywords: Asthma/etiology/genetics/immunology ; *Biological Evolution ; *Curriculum ; Disease Susceptibility ; Drug Resistance ; *Education, Medical ; Endemic Diseases ; Humans ; Immunity, Innate ; Immunoglobulin E/immunology ; Malaria/epidemiology/immunology ; Schistosomiasis/epidemiology/immunology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Public health. International groups battle cholera in Zimbabwe (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, Robert -- New York, N.Y. -- Science. 2009 Feb 13;323(5916):860-1. doi: 10.1126/science.323.5916.860.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19213882" target="_blank"〉PubMed〈/a〉
    Keywords: Cholera/*epidemiology/prevention & control ; *Disease Outbreaks ; Humans ; Internationality ; *Public Health ; Public Health Administration ; World Health Organization ; Zimbabwe/epidemiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Developing psychomotor skills the Wii way (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hill, Ciaran Scott -- New York, N.Y. -- Science. 2009 Feb 27;323(5918):1169. doi: 10.1126/science.323.5918.1169a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19251611" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Motor Skills ; *Psychomotor Performance ; *Video Games
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    DICER1 mutations in familial pleuropulmonary blastoma (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-06-27
    Description: Pleuropulmonary blastoma (PPB) is a rare pediatric lung tumor that is often part of an inherited cancer syndrome. PPBs consist of mesenchymal cells that are susceptible to malignant transformation and cysts lined by epithelial cells. In a subset of patients, overgrowth of the cysts by mesenchymal cells leads to sarcoma formation. Here, we show that 11 multiplex PPB families harbor heterozygous germline mutations in DICER1, a gene encoding an endoribonuclease critical to the generation of small noncoding regulatory RNAs. Expression of DICER1 protein was undetectable in the epithelial component of PPB tumors but was retained in the malignant mesenchyme (sarcoma). We hypothesize that loss of DICER1 in the epithelium of the developing lung alters the regulation of diffusible factors that promote mesenchymal proliferation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098036/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098036/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hill, D Ashley -- Ivanovich, Jennifer -- Priest, John R -- Gurnett, Christina A -- Dehner, Louis P -- Desruisseau, David -- Jarzembowski, Jason A -- Wikenheiser-Brokamp, Kathryn A -- Suarez, Brian K -- Whelan, Alison J -- Williams, Gretchen -- Bracamontes, Dawn -- Messinger, Yoav -- Goodfellow, Paul J -- P30 CA091842/CA/NCI NIH HHS/ -- P30 CA091842-07/CA/NCI NIH HHS/ -- P30 CA091842-08/CA/NCI NIH HHS/ -- R01 CA143167/CA/NCI NIH HHS/ -- R01 HL109265/HL/NHLBI NIH HHS/ -- UL1 RR024992/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2009 Aug 21;325(5943):965. doi: 10.1126/science.1174334. Epub 2009 Jun 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Washington University Medical Center, St. Louis, MO 63110, USA. dashill@cnmc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19556464" target="_blank"〉PubMed〈/a〉
    Keywords: DEAD-box RNA Helicases/chemistry/*genetics ; Epithelium/metabolism ; Female ; Genetic Predisposition to Disease ; *Germ-Line Mutation ; Heterozygote ; Humans ; Lung Neoplasms/enzymology/*genetics/pathology ; Male ; Pedigree ; Pulmonary Blastoma/enzymology/*genetics/pathology ; Ribonuclease III/chemistry/*genetics
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    Blue or red? Exploring the effect of color on cognitive task performances (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-07
    Description: Existing research reports inconsistent findings with regard to the effect of color on cognitive task performances. Some research suggests that blue or green leads to better performances than red; other studies record the opposite. Current work reconciles this discrepancy. We demonstrate that red (versus blue) color induces primarily an avoidance (versus approach) motivation (study 1, n = 69) and that red enhances performance on a detail-oriented task, whereas blue enhances performance on a creative task (studies 2 and 3, n = 208 and 118). Further, we replicate these results in the domains of product design (study 4, n = 42) and persuasive message evaluation (study 5, n = 161) and show that these effects occur outside of individuals' consciousness (study 6, n = 68). We also provide process evidence suggesting that the activation of alternative motivations mediates the effect of color on cognitive task performances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mehta, Ravi -- Zhu, Rui Juliet -- New York, N.Y. -- Science. 2009 Feb 27;323(5918):1226-9. doi: 10.1126/science.1169144. Epub 2009 Feb 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sauder School of Business, University of British Columbia, 2053 Main Mall, Vancouver, BC V6T 1Z2, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19197022" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Cognition ; *Color ; Creativity ; Female ; Humans ; Male ; *Mental Processes ; Mental Recall ; Motivation ; *Task Performance and Analysis ; Young Adult
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    Adding a T to the three R's. Education & technology. Introduction (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-01-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hines, Pamela J -- Jasny, Barbara R -- Mervis, Jeffrey -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):53. doi: 10.1126/science.323.5910.53a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119209" target="_blank"〉PubMed〈/a〉
    Keywords: *Education/methods ; *Educational Technology ; Humans ; *Learning ; Teaching Materials
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    Understanding the spreading patterns of mobile phone viruses (2009)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2009-04-04
    Description: We modeled the mobility of mobile phone users in order to study the fundamental spreading patterns that characterize a mobile virus outbreak. We find that although Bluetooth viruses can reach all susceptible handsets with time, they spread slowly because of human mobility, offering ample opportunities to deploy antiviral software. In contrast, viruses using multimedia messaging services could infect all users in hours, but currently a phase transition on the underlying call graph limits them to only a small fraction of the susceptible users. These results explain the lack of a major mobile virus breakout so far and predict that once a mobile operating system's market share reaches the phase transition point, viruses will pose a serious threat to mobile communications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Pu -- Gonzalez, Marta C -- Hidalgo, Cesar A -- Barabasi, Albert-Laszlo -- New York, N.Y. -- Science. 2009 May 22;324(5930):1071-6. doi: 10.1126/science.1167053. Epub 2009 Apr 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Complex Network Research, Departments of Physics, Biology, and Computer Science, Northeastern University, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19342553" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Phones ; *Computer Security ; Humans ; Time Factors
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    Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-11
    Description: The nuclear factor kappaB (NF-kappaB) transcription factor regulates cellular stress responses and the immune response to infection. NF-kappaB activation results in oscillations in nuclear NF-kappaB abundance. To define the function of these oscillations, we treated cells with repeated short pulses of tumor necrosis factor-alpha at various intervals to mimic pulsatile inflammatory signals. At all pulse intervals that were analyzed, we observed synchronous cycles of NF-kappaB nuclear translocation. Lower frequency stimulations gave repeated full-amplitude translocations, whereas higher frequency pulses gave reduced translocation, indicating a failure to reset. Deterministic and stochastic mathematical models predicted how negative feedback loops regulate both the resetting of the system and cellular heterogeneity. Altering the stimulation intervals gave different patterns of NF-kappaB-dependent gene expression, which supports the idea that oscillation frequency has a functional role.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785900/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785900/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ashall, Louise -- Horton, Caroline A -- Nelson, David E -- Paszek, Pawel -- Harper, Claire V -- Sillitoe, Kate -- Ryan, Sheila -- Spiller, David G -- Unitt, John F -- Broomhead, David S -- Kell, Douglas B -- Rand, David A -- See, Violaine -- White, Michael R H -- BB/C007158/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/C008219/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/C520471/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/D010748/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/E004210/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/E012965/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/F005938/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BBC0071581/Biotechnology and Biological Sciences Research Council/United Kingdom -- BBC0082191/Biotechnology and Biological Sciences Research Council/United Kingdom -- BBC5204711/Biotechnology and Biological Sciences Research Council/United Kingdom -- BBD0107481/Biotechnology and Biological Sciences Research Council/United Kingdom -- BBF0059381/Biotechnology and Biological Sciences Research Council/United Kingdom -- G0500346/Medical Research Council/United Kingdom -- G0500346(73596)/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2009 Apr 10;324(5924):242-6. doi: 10.1126/science.1164860.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Cell Imaging, School of Biological Sciences, Bioscience Research Building, Crown Street, Liverpool, L69 7ZB, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19359585" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Animals ; Cell Line ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Feedback, Physiological ; *Gene Expression ; Humans ; I-kappa B Proteins/metabolism ; Mice ; Models, Biological ; Models, Statistical ; NF-kappa B/*metabolism ; Phosphorylation ; Recombinant Fusion Proteins/metabolism ; Stochastic Processes ; Transcription Factor RelA/*metabolism ; *Transcription, Genetic ; Transfection ; Tumor Necrosis Factor-alpha/*metabolism
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    Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-03
    Description: Although senile plaques focally disrupt neuronal health, the functional response of astrocytes to Alzheimer's disease pathology is unknown. Using multiphoton fluorescence lifetime imaging microscopy in vivo, we quantitatively imaged astrocytic calcium homeostasis in a mouse model of Alzheimer's disease. Resting calcium was globally elevated in the astrocytic network, but was independent of proximity to individual plaques. Time-lapse imaging revealed that calcium transients in astrocytes were more frequent, synchronously coordinated across long distances, and uncoupled from neuronal activity. Furthermore, rare intercellular calcium waves were observed, but only in mice with amyloid-beta plaques, originating near plaques and spreading radially at least 200 micrometers. Thus, although neurotoxicity is observed near amyloid-beta deposits, there exists a more general astrocyte-based network response to focal pathology.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884172/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884172/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuchibhotla, Kishore V -- Lattarulo, Carli R -- Hyman, Bradley T -- Bacskai, Brian J -- EB000768/EB/NIBIB NIH HHS/ -- F31 NS058075-02/NS/NINDS NIH HHS/ -- NS580752/NS/NINDS NIH HHS/ -- R01 AG008487/AG/NIA NIH HHS/ -- R01 AG008487-19/AG/NIA NIH HHS/ -- R01 EB000768/EB/NIBIB NIH HHS/ -- R01 EB000768-08/EB/NIBIB NIH HHS/ -- S10 RR025645/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2009 Feb 27;323(5918):1211-5. doi: 10.1126/science.1169096.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts General Hospital, Department of Neurology/Alzheimer's Disease Research Laboratory, 114 16th Street, Charlestown, MA 02129, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19251629" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/pathology/*physiopathology ; Amyloid beta-Peptides/analysis ; Animals ; Astrocytes/metabolism/pathology/*physiology ; Calcium/*metabolism ; *Calcium Signaling ; Disease Models, Animal ; Homeostasis ; Humans ; Mice ; Mice, Transgenic ; Microscopy, Fluorescence, Multiphoton ; Neurons/pathology/physiology ; Plaque, Amyloid/pathology
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    Cognitive science. Twins may think alike too, MRI brain study suggests (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Mar 27;323(5922):1658. doi: 10.1126/science.323.5922.1658a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325088" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*physiology ; Brain Mapping ; *Cognition ; *Genes ; Humans ; Magnetic Resonance Imaging ; Male ; *Memory, Short-Term ; Siblings ; *Thinking ; Twin Studies as Topic ; *Twins, Monozygotic
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    Linguistics. How many languages? Linguists discover new tongues in China (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erard, Michael -- New York, N.Y. -- Science. 2009 Apr 17;324(5925):332-3. doi: 10.1126/science.324.5925.332a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19372408" target="_blank"〉PubMed〈/a〉
    Keywords: China ; *Ethnic Groups ; Humans ; *Language ; *Linguistics ; Minority Groups
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    DNA binding site sequence directs glucocorticoid receptor structure and activity (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-18
    Description: Genes are not simply turned on or off, but instead their expression is fine-tuned to meet the needs of a cell. How genes are modulated so precisely is not well understood. The glucocorticoid receptor (GR) regulates target genes by associating with specific DNA binding sites, the sequences of which differ between genes. Traditionally, these binding sites have been viewed only as docking sites. Using structural, biochemical, and cell-based assays, we show that GR binding sequences, differing by as little as a single base pair, differentially affect GR conformation and regulatory activity. We therefore propose that DNA is a sequence-specific allosteric ligand of GR that tailors the activity of the receptor toward specific target genes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777810/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777810/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meijsing, Sebastiaan H -- Pufall, Miles A -- So, Alex Y -- Bates, Darren L -- Chen, Lin -- Yamamoto, Keith R -- GM08537/GM/NIGMS NIH HHS/ -- R01 CA020535/CA/NCI NIH HHS/ -- R01 CA020535-31/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2009 Apr 17;324(5925):407-10. doi: 10.1126/science.1164265.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19372434" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Binding Sites ; Cell Line, Tumor ; Crystallography, X-Ray ; DNA/*chemistry/*metabolism ; Humans ; Ligands ; Models, Molecular ; Mutation ; Protein Conformation ; Protein Isoforms/chemistry/metabolism ; Protein Multimerization ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Rats ; Receptors, Glucocorticoid/chemistry/genetics/*metabolism ; Transcriptional Activation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1 (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-21
    Description: Heat shock factor 1 (HSF1) is essential for protecting cells from protein-damaging stress associated with misfolded proteins and regulates the insulin-signaling pathway and aging. Here, we show that human HSF1 is inducibly acetylated at a critical residue that negatively regulates DNA binding activity. Activation of the deacetylase and longevity factor SIRT1 prolonged HSF1 binding to the heat shock promoter Hsp70 by maintaining HSF1 in a deacetylated, DNA-binding competent state. Conversely, down-regulation of SIRT1 accelerated the attenuation of the heat shock response (HSR) and release of HSF1 from its cognate promoter elements. These results provide a mechanistic basis for the requirement of HSF1 in the regulation of life span and establish a role for SIRT1 in protein homeostasis and the HSR.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429349/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429349/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Westerheide, Sandy D -- Anckar, Julius -- Stevens, Stanley M Jr -- Sistonen, Lea -- Morimoto, Richard I -- R01 AG026647/AG/NIA NIH HHS/ -- R01 AG026647-01/AG/NIA NIH HHS/ -- R01 AG026647-02/AG/NIA NIH HHS/ -- R01 AG026647-03/AG/NIA NIH HHS/ -- R01 AG026647-04/AG/NIA NIH HHS/ -- R01 GM038109/GM/NIGMS NIH HHS/ -- R37 GM038109/GM/NIGMS NIH HHS/ -- R37 GM038109-19/GM/NIGMS NIH HHS/ -- R37 GM038109-20/GM/NIGMS NIH HHS/ -- R37 GM038109-21/GM/NIGMS NIH HHS/ -- R37 GM038109-22/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2009 Feb 20;323(5917):1063-6. doi: 10.1126/science.1165946.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19229036" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Amino Acid Sequence ; Animals ; Cell Aging/*physiology ; Chromatin Immunoprecipitation ; DNA/metabolism ; DNA-Binding Proteins/*metabolism ; Down-Regulation ; HSP70 Heat-Shock Proteins/*genetics ; HeLa Cells ; *Heat-Shock Response ; Homeostasis ; Humans ; Mice ; Molecular Sequence Data ; *Promoter Regions, Genetic ; RNA, Small Interfering ; Sirtuin 1 ; Sirtuins/genetics/*metabolism ; *Stress, Psychological ; Transcription Factors/*metabolism ; Transfection
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    Shifts in lake N:P stoichiometry and nutrient limitation driven by atmospheric nitrogen deposition (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-11-07
    Description: Human activities have more than doubled the amount of nitrogen (N) circulating in the biosphere. One major pathway of this anthropogenic N input into ecosystems has been increased regional deposition from the atmosphere. Here we show that atmospheric N deposition increased the stoichiometric ratio of N and phosphorus (P) in lakes in Norway, Sweden, and Colorado, United States, and, as a result, patterns of ecological nutrient limitation were shifted. Under low N deposition, phytoplankton growth is generally N-limited; however, in high-N deposition lakes, phytoplankton growth is consistently P-limited. Continued anthropogenic amplification of the global N cycle will further alter ecological processes, such as biogeochemical cycling, trophic dynamics, and biological diversity, in the world's lakes, even in lakes far from direct human disturbance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elser, James J -- Andersen, Tom -- Baron, Jill S -- Bergstrom, Ann-Kristin -- Jansson, Mats -- Kyle, Marcia -- Nydick, Koren R -- Steger, Laura -- Hessen, Dag O -- New York, N.Y. -- Science. 2009 Nov 6;326(5954):835-7. doi: 10.1126/science.1176199.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA. j.elser@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19892979" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/*chemistry ; Biodiversity ; Biomass ; Colorado ; *Ecosystem ; Food Chain ; Fresh Water/*chemistry ; Human Activities ; Humans ; Nitrates/analysis ; Nitrogen/*analysis ; Norway ; Phosphorus/*analysis ; Phytoplankton/growth & development/*physiology ; Sweden ; Trees
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    Neural mechanisms of a genome-wide supported psychosis variant (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-02
    Description: Schizophrenia is a devastating, highly heritable brain disorder of unknown etiology. Recently, the first common genetic variant associated on a genome-wide level with schizophrenia and possibly bipolar disorder was discovered in ZNF804A (rs1344706). We show, by using an imaging genetics approach, that healthy carriers of rs1344706 risk genotypes exhibit no changes in regional activity but pronounced gene dosage-dependent alterations in functional coupling (correlated activity) of dorsolateral prefrontal cortex (DLPFC) across hemispheres and with hippocampus, mirroring findings in patients, and abnormal coupling of amygdala. Our findings establish disturbed connectivity as a neurogenetic risk mechanism for psychosis supported by genome-wide association, show that rs1344706 or variation in linkage disequilibrium is functional in human brain, and validate the intermediate phenotype strategy in psychiatry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Esslinger, Christine -- Walter, Henrik -- Kirsch, Peter -- Erk, Susanne -- Schnell, Knut -- Arnold, Claudia -- Haddad, Leila -- Mier, Daniela -- Opitz von Boberfeld, Carola -- Raab, Kyeon -- Witt, Stephanie H -- Rietschel, Marcella -- Cichon, Sven -- Meyer-Lindenberg, Andreas -- New York, N.Y. -- Science. 2009 May 1;324(5927):605. doi: 10.1126/science.1167768.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19407193" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Affective Symptoms/genetics/physiopathology ; Bipolar Disorder/genetics/physiopathology ; Brain Mapping ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Hippocampus/*physiology ; Humans ; Kruppel-Like Transcription Factors/*genetics ; Magnetic Resonance Imaging ; Male ; Mental Processes ; Phenotype ; *Polymorphism, Single Nucleotide ; Prefrontal Cortex/*physiology ; Schizophrenia/*genetics/physiopathology
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    Demography. Chinese men: a rising tide of troublemakers? (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Feb 27;323(5918):1166. doi: 10.1126/science.323.5918.1166.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19251607" target="_blank"〉PubMed〈/a〉
    Keywords: China ; Crime ; Female ; Humans ; Male ; *Marriage ; *Sex Ratio ; *Social Problems
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    Biomedical research. A first step in relaxing restrictions on stem cell research (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2009 Mar 13;323(5920):1412-3. doi: 10.1126/science.323.5920.1412.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19286523" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Embryo Research/economics/*legislation & jurisprudence ; *Embryonic Stem Cells ; Financing, Government/legislation & jurisprudence ; Guidelines as Topic ; Humans ; National Institutes of Health (U.S.) ; Pluripotent Stem Cells ; Research Support as Topic/*legislation & jurisprudence ; United States
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  • 94
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    Evolution of the monkey crouch (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wasserman, Edward A -- Blumberg, Mark S -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):812. doi: 10.1126/science.325_812a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19679792" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomechanical Phenomena ; Horses/*physiology ; Humans ; *Locomotion ; *Posture ; Sports/*physiology
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  • 95
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    Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-18
    Description: Genomic expansions of simple tandem repeats can give rise to toxic RNAs that contain expanded repeats. In myotonic dystrophy, the expression of expanded CUG repeats (CUGexp) causes abnormal regulation of alternative splicing and neuromuscular dysfunction. We used a transgenic mouse model to show that derangements of myotonic dystrophy are reversed by a morpholino antisense oligonucleotide, CAG25, that binds to CUGexp RNA and blocks its interaction with muscleblind-like 1 (MBNL1), a CUGexp-binding protein. CAG25 disperses nuclear foci of CUGexp RNA and reduces the overall burden of this toxic RNA. As MBNL1 is released from sequestration, the defect of alternative splicing regulation is corrected, thereby restoring ion channel function. These findings suggest an alternative use of antisense methods, to inhibit deleterious interactions of proteins with pathogenic RNAs.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109973/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109973/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wheeler, Thurman M -- Sobczak, Krzysztof -- Lueck, John D -- Osborne, Robert J -- Lin, Xiaoyan -- Dirksen, Robert T -- Thornton, Charles A -- AR/NS48143/AR/NIAMS NIH HHS/ -- AR046806/AR/NIAMS NIH HHS/ -- K08 NS064293/NS/NINDS NIH HHS/ -- K24 AR048143/AR/NIAMS NIH HHS/ -- NIDCR-T32DE07202/DE/NIDCR NIH HHS/ -- R01 AR046806/AR/NIAMS NIH HHS/ -- R01 AR049077/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2009 Jul 17;325(5938):336-9. doi: 10.1126/science.1173110.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Neurology, Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19608921" target="_blank"〉PubMed〈/a〉
    Keywords: 3' Untranslated Regions/genetics/*metabolism ; Actins/genetics ; Alternative Splicing ; Animals ; Cell Line ; Cell Nucleus/metabolism ; Chloride Channels/metabolism ; DNA-Binding Proteins/*metabolism ; Humans ; Mice ; Mice, Knockout ; Mice, Transgenic ; Myotonic Dystrophy/*drug therapy/*genetics/metabolism ; Myotonin-Protein Kinase ; Oligodeoxyribonucleotides, Antisense/*pharmacology/therapeutic use ; Protein-Serine-Threonine Kinases/genetics ; RNA, Messenger/genetics ; RNA-Binding Proteins/*metabolism ; Transcription, Genetic ; *Trinucleotide Repeat Expansion
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    Biomedical policy. Draft stem cell guidelines please many, disappoint some (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- Kaiser, Jocelyn -- New York, N.Y. -- Science. 2009 Apr 24;324(5926):446. doi: 10.1126/science.324_446.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19390007" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Embryo Research/economics/*legislation & jurisprudence ; Embryonic Stem Cells ; Financing, Government/*legislation & jurisprudence ; Guidelines as Topic ; Humans ; National Institutes of Health (U.S.) ; Public Policy ; Research Support as Topic/*legislation & jurisprudence ; *Stem Cells ; United States
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    Behavior. Surprising emotions (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, Eliot R -- Mackie, Diane M -- New York, N.Y. -- Science. 2009 Jan 9;323(5911):215-6. doi: 10.1126/science.1168650.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA. esmith4@indiana.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19131617" target="_blank"〉PubMed〈/a〉
    Keywords: *Emotions ; Humans ; Prejudice ; *Social Behavior ; *Social Identification
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    Diversity and complexity in DNA recognition by transcription factors (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-16
    Description: Sequence preferences of DNA binding proteins are a primary mechanism by which cells interpret the genome. Despite the central importance of these proteins in physiology, development, and evolution, comprehensive DNA binding specificities have been determined experimentally for only a few proteins. Here, we used microarrays containing all 10-base pair sequences to examine the binding specificities of 104 distinct mouse DNA binding proteins representing 22 structural classes. Our results reveal a complex landscape of binding, with virtually every protein analyzed possessing unique preferences. Roughly half of the proteins each recognized multiple distinctly different sequence motifs, challenging our molecular understanding of how proteins interact with their DNA binding sites. This complexity in DNA recognition may be important in gene regulation and in the evolution of transcriptional regulatory networks.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905877/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905877/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Badis, Gwenael -- Berger, Michael F -- Philippakis, Anthony A -- Talukder, Shaheynoor -- Gehrke, Andrew R -- Jaeger, Savina A -- Chan, Esther T -- Metzler, Genita -- Vedenko, Anastasia -- Chen, Xiaoyu -- Kuznetsov, Hanna -- Wang, Chi-Fong -- Coburn, David -- Newburger, Daniel E -- Morris, Quaid -- Hughes, Timothy R -- Bulyk, Martha L -- R01 HG003985/HG/NHGRI NIH HHS/ -- R01 HG003985-01/HG/NHGRI NIH HHS/ -- R01 HG003985-02/HG/NHGRI NIH HHS/ -- R01 HG003985-03/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2009 Jun 26;324(5935):1720-3. doi: 10.1126/science.1162327. Epub 2009 May 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19443739" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Base Sequence ; Binding Sites ; DNA/chemistry/*metabolism ; Electrophoretic Mobility Shift Assay ; Gene Expression Regulation ; Gene Regulatory Networks ; Humans ; Mice ; Protein Array Analysis ; Protein Binding ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/chemistry/metabolism ; Transcription Factors/*chemistry/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Ecology. Reducing the risks of the wildlife trade (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, Katherine F -- Behrens, Michael -- Schloegel, Lisa M -- Marano, Nina -- Burgiel, Stas -- Daszak, Peter -- New York, N.Y. -- Science. 2009 May 1;324(5927):594-5. doi: 10.1126/science.1174460.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brown University, Ecology and Evolutionary Biology, Providence, RI 02912, USA. katherine_smith@brown.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19407185" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Wild ; Biodiversity ; Carrier State/veterinary ; *Commerce/legislation & jurisprudence/statistics & numerical data ; Communicable Diseases/transmission/veterinary ; Ecosystem ; Humans ; International Cooperation ; Public Health ; Public Policy ; Risk Assessment ; United States ; Zoonoses
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Lab experiments are a major source of knowledge in the social sciences (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-11-11
    Description: Laboratory experiments are a widely used methodology for advancing causal knowledge in the physical and life sciences. With the exception of psychology, the adoption of laboratory experiments has been much slower in the social sciences, although during the past two decades the use of lab experiments has accelerated. Nonetheless, there remains considerable resistance among social scientists who argue that lab experiments lack "realism" and generalizability. In this article, we discuss the advantages and limitations of laboratory social science experiments by comparing them to research based on nonexperimental data and to field experiments. We argue that many recent objections against lab experiments are misguided and that even more lab experiments should be conducted.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Falk, Armin -- Heckman, James J -- New York, N.Y. -- Science. 2009 Oct 23;326(5952):535-8. doi: 10.1126/science.1168244.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Economic Policy Research, Center for Economic Studies and Ifo Institute for Economic Research, Institute for the Study of Labor (IZA), and University of Bonn, 53113 Bonn, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19900889" target="_blank"〉PubMed〈/a〉
    Keywords: *Economics ; Games, Experimental ; Humans ; Laboratories ; *Research ; Research Design ; *Social Sciences
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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