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  • American Association for the Advancement of Science (AAAS)  (2,207)
  • American Association of Petroleum Geologists (AAPG)
  • 1985-1989  (2,207)
  • 1986  (2,207)
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  • 1985-1989  (2,207)
Year
  • 1
    Publication Date: 1986-11-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1986 Nov 28;234(4780):1071-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17778945" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 2
    Publication Date: 1986-11-14
    Description: Organic single crystals provide an ideal model for studying the factors that influence chemical processes in structured media. Reaction trajectories are well defined and reveal the influence of spontaneous mechanical stresses equivalent to tens of thousands of atmospheres. Analysis of molecular and crystal structures helps to explain both local mechanical properties, which influence reactions, and bulk properties such as melting point, compressibility, and surface energy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McBride, J M -- Segmuller, B E -- Hollingsworth, M D -- Mills, D E -- Weber, B A -- New York, N.Y. -- Science. 1986 Nov 14;234(4778):830-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17758105" target="_blank"〉PubMed〈/a〉
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-05-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉L, K -- New York, N.Y. -- Science. 1986 May 9;232(4751):779-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17769577" target="_blank"〉PubMed〈/a〉
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  • 4
    Publication Date: 1986-10-17
    Description: The regulation of nerve growth factor (NGF) protein and NGF messenger RNA (mRNA) in the developing rat brain has been studied to assess the hypothesis that NGF supports the differentiation of cholinergic neurons in the basal forebrain. In the adult, the major targets of these neurons, the hippocampus and neocortex, contain the highest concentrations of NGF mRNA, but comparatively low ratios of NGF protein to its mRNA. In contrast, a high concentration of NGF protein and a low concentration of NGF mRNA were seen in the basal forebrain, consistent with retrograde transport of NGF protein into this region from the neocortex and hippocampus. In these two target regions NGF and NGF mRNA were barely detectable at birth, their concentrations increased to a peak at day 21, and then NGF mRNA, but not NGF protein, declined threefold by day 35. NGF accumulation in the basal forebrain paralleled that in the target regions and preceded an increase in choline acetyltransferase, suggesting that the differentiation of cholinergic projection neurons is indeed regulated by retrogradely transported NGF. In addition, high ratios of NGF protein to NGF mRNA, comparable to that in the basal forebrain, were seen in the olfactory bulb and cerebellum, suggesting that NGF may be transported into these regions by unidentified neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Large, T H -- Bodary, S C -- Clegg, D O -- Weskamp, G -- Otten, U -- Reichardt, L F -- NS21824/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1986 Oct 17;234(4774):352-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3764415" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*growth & development/metabolism ; Brain Chemistry ; Cerebellum/analysis ; Cerebral Cortex/analysis ; Hippocampus/analysis ; Nerve Growth Factors/analysis/*biosynthesis/genetics ; RNA, Messenger/analysis ; Rats ; Rats, Inbred Strains
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazarides, E -- New York, N.Y. -- Science. 1986 Dec 12;234(4782):1448.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17755067" target="_blank"〉PubMed〈/a〉
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  • 6
    Publication Date: 1986-10-03
    Description: Transducin is a guanyl nucleotide-binding protein that couples rhodopsin photolysis to hydrolysis of guanosine 3',5'-monophosphate in rod photoreceptor cells of vertebrate retinas. Several complementary DNA clones encoding transducin subunits have recently been characterized. One clone, isolated from a bovine retina complementary DNA library, encodes a previously unidentified polypeptide with an amino acid sequence 78% identical to the sequence of the alpha subunit of bovine rod outer segment transducin. Antibodies to a synthetic peptide with amino acid sequence derived specifically from this novel polypeptide recognize a 41-kilodalton polypeptide in homogenates of bovine retina. Localization of this polypeptide in bovine retina by indirect immunofluorescence demonstrates that it is expressed only in cone outer segments. Antibodies to specific sequences found only in the rod transducin alpha subunit recognize a polypeptide localized only in the rod outer segment. Therefore, bovine rod and cone cells each express structurally related yet significantly different forms of transducin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lerea, C L -- Somers, D E -- Hurley, J B -- Klock, I B -- Bunt-Milam, A H -- EYO 1311/EY/NEI NIH HHS/ -- EYO 1730/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1986 Oct 3;234(4772):77-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3529395" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cattle ; DNA/genetics ; Fluorescent Antibody Technique ; Membrane Proteins/genetics/*physiology ; Photoreceptor Cells/*metabolism ; Transducin
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  • 7
    Publication Date: 1986-04-04
    Description: A lectin in Giardia lamblia was activated by secretions from the human duodenum, the environment where the parasite lives. Incubation of the secretions with trypsin inhibitors prevented the appearance of lectin activity, implicating proteases as the activating agent. Accordingly, lectin activation was also produced by crystalline trypsin and Pronase; other proteases tested were ineffective. When activated, the lectin agglutinated intestinal cells to which the parasite adheres in vivo. The lectin was most specific to mannose-6-phosphate and apparently was bound to the plasma membrane. Activation of a parasite lectin by a host protease represents a novel mechanism of host-parasite interaction and may contribute to the affinity of Giardia lamblia to the infection site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lev, B -- Ward, H -- Keusch, G T -- Pereira, M E -- P-1-P30-AM 39428-01/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3513312" target="_blank"〉PubMed〈/a〉
    Keywords: Agglutination ; Animals ; Duodenum/enzymology/parasitology ; Giardia/*metabolism ; *Host-Parasite Interactions ; Humans ; Intestine, Small/enzymology/*parasitology ; Lectins/*metabolism ; Mice ; Peptide Hydrolases/*metabolism ; Sheep ; Species Specificity ; Trypsin/metabolism
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  • 8
    Publication Date: 1986-01-31
    Description: p-Chloromercuriphenylsulfonic acid (PCMS), a sulfhydryl inhibitor, prevented the mycelial-to-yeast transition of the dimorphic fungal pathogen, Histoplasma capsulatum. The effect of PCMS was specific for the mycelial-to-yeast transformation; it had no effect on growth of either the yeast or mycelial forms or on the yeast-to-mycelial transition. The failure of PCMS-treated mycelia to transform to yeast was permanent and irreversible. PCMS-treated mycelia could not infect mice but could stimulate resistance to infection by a pathogenic strain of Histoplasma capsulatum. These results suggest a new general strategy for vaccine development in diseases caused by dimorphic pathogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Medoff, G -- Sacco, M -- Maresca, B -- Schlessinger, D -- Painter, A -- Kobayashi, G S -- Carratu, L -- AI 07015/AI/NIAID NIH HHS/ -- AI 07172/AI/NIAID NIH HHS/ -- AI 16228/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 Jan 31;231(4737):476-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3001938" target="_blank"〉PubMed〈/a〉
    Keywords: 4-Chloromercuribenzenesulfonate/pharmacology ; Animals ; Cytochromes/metabolism ; Energy Metabolism/drug effects ; Fungal Proteins/biosynthesis ; Histoplasma/drug effects/pathogenicity/*physiology ; Histoplasmosis/etiology ; Kinetics ; Mice ; Oxidative Phosphorylation/drug effects ; Oxygen Consumption/drug effects
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Melack, J M -- New York, N.Y. -- Science. 1986 May 23;232(4753):1031-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17759306" target="_blank"〉PubMed〈/a〉
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mellett, J S -- New York, N.Y. -- Science. 1986 Sep 19;233(4770):1246-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17843344" target="_blank"〉PubMed〈/a〉
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-02-21
    Description: Eight major episodes of biological extinction of marine families over the past 250 million years stand significantly above local background (P 〈 0.05). These events are more pronounced when analyzed at the level of genus, and generic data exhibit additional apparent extinction events in the Aptian (Cretaceous) and Pliocene (Tertiary) Stages. Time-series analysis of these records strongly suggests a 26-million-year periodicity. This conclusion is robust even when adjusted for simultaneous testing of many trial periods. When the time series is limited to the four best-dated events (Cenomanian, Maestrichtian, upper Eocene, and middle Miocene), the hypothesis of randomness is also rejected for the 26-million-year period (P 〈 0.0002).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raup, D M -- Sepkoski, J J Jr -- New York, N.Y. -- Science. 1986 Feb 21;231:833-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geophysical Sciences, University of Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11542060" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; *Fossils ; Geological Phenomena ; Geology ; Marine Biology ; Paleontology/*statistics & numerical data ; *Periodicity
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  • 12
    Publication Date: 1986-12-19
    Description: A strain of pigs bearing three immunogenetically defined lipoprotein-associated markers (allotypes), designated Lpb5, Lpr1, and Lpu1, has marked hypercholesterolemia on a low fat, cholesterol-free diet. Unlike individuals with familial hypercholesterolemia or WHHL rabbits, the affected pigs have normal low density lipoprotein receptor activity. The animals, by 7 months of age, have extensive atherosclerotic lesions in all three coronary arteries. This strain of pig represents an animal model for atherosclerosis and hypercholesterolemia associated with mutations affecting the structures of plasma lipoproteins. One of the variant apolipoproteins, Lpb5, is apolipoprotein-B. A second variant apolipoprotein (Lpr1), termed apo-R, is a 23-kilodalton protein present in both the very low density (d less than 1.006 g/ml) and the very high density (d greater than 1.21 g/ml) fractions of pig plasma. Isoforms of this protein correlate with two Lpr alleles, Lpr1 and Lpr2. The Lpr genes segregate independently of the Lpb5 and Lpu1 alleles. The Lpu1 allotype is a component of low density lipoprotein and is genetically linked to Lpb5.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rapacz, J -- Hasler-Rapacz, J -- Taylor, K M -- Checovich, W J -- Attie, A D -- AG05-856/AG/NIA NIH HHS/ -- HL30594/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1986 Dec 19;234(4783):1573-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3787263" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Apolipoproteins B/genetics ; Arteriosclerosis/blood/*genetics ; Cholesterol/blood ; *Disease Models, Animal ; Female ; Genotype ; Hypercholesterolemia/blood/*genetics ; Immunologic Tests ; Lipoproteins/blood/*genetics ; Lipoproteins, LDL/blood/genetics ; Lipoproteins, VLDL/blood/genetics ; Male ; Mutation ; Receptors, LDL/metabolism ; Swine
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-12-12
    Description: Malaria exacts a toll of disease to people in the Tropics that seems incomprehensible to those only familiar with medicine and human health in the developed world. The methods of molecular biology, immunology, and cell biology are now being used to develop an antimalarial vaccine. The Plasmodium parasites that cause malaria have many stages in their life cycle. Each stage is antigenically distinct and potentially could be interrupted by different vaccines. However, achieving complete protection by vaccination may require a better understanding of the complexities of B- and T-cell priming in natural infections and the development of an appropriate adjuvant for use in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, L H -- Howard, R J -- Carter, R -- Good, M F -- Nussenzweig, V -- Nussenzweig, R S -- P01-AI17429/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 Dec 12;234(4782):1349-56.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2431481" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Protozoan/analysis ; Arthropod Vectors ; Epitopes/analysis ; Erythrocytes/parasitology ; Humans ; *Immunotherapy ; Malaria/immunology/*prevention & control/transmission ; Molecular Weight ; Mosquito Control ; Plasmodium/immunology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; *Vaccines
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-07-18
    Description: Japan has experienced many major earthquake disasters in the past. Early in this century research began that was aimed at predicting the occurrence of earthquakes, and in 1965 an earthquake prediction program was started as a national project. In 1978 a program for constant monitoring and assessment was formally inaugurated with the goal of forecasting the major earthquake that is expected to occur in the near future in the Tokai district of central Honshu Island. The issue of predicting the anticipated Tokai earthquake is discussed in this article as well as the results of research on major recent earthquakes in Japan-the Izu earthquakes (1978 and 1980) and the Japan Sea earthquake (1983).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mogi, K -- New York, N.Y. -- Science. 1986 Jul 18;233(4761):324-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737619" target="_blank"〉PubMed〈/a〉
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rebbi, C -- New York, N.Y. -- Science. 1986 Jul 4;233(4759):113-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812904" target="_blank"〉PubMed〈/a〉
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  • 16
    Publication Date: 1986-12-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raupp, M J -- Barbosa, P -- Leonhardt, B A -- New York, N.Y. -- Science. 1986 Dec 19;234(4783):1588-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17816509" target="_blank"〉PubMed〈/a〉
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  • 17
    Publication Date: 1986-11-28
    Description: The three-dimensional structure of favin, the glucose- and mannose-binding lectin of Vicia faba (vetch, broad bean), has been determined at a resolution of 2.8 angstroms by molecular replacement. The crystals contain specifically bound glucose and provide the first high-resolution view of specific saccharide binding in a leguminous lectin. The structure is similar to those of concanavalin A (Con A) and green pea lectin; differences from Con A show that minimal changes are needed to accommodate the cyclic permutation in amino acid sequence between the two molecules. The molecule is an ellipsoidal dimer dominated by extensive beta structures. Each protomer contains binding sites for two divalent metal ions (Mn2+ and Ca2+) and a specific saccharide. Glucose is bound by favin in a cleft in the molecular surface and has noncovalent contacts primarily with two peptide loops, one of which contains several metal ion ligands. The specific carbohydrate-binding site is similar to that of Con A in location and general peptide folding, despite several differences in specific amino acid residues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reeke, G N Jr -- Becker, J W -- AI-11378/AI/NIAID NIH HHS/ -- GM-22663/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1986 Nov 28;234(4780):1108-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3775378" target="_blank"〉PubMed〈/a〉
    Keywords: Concanavalin A ; *Lectins ; Plant Lectins ; Plants ; Protein Conformation
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  • 18
    Publication Date: 1986-05-09
    Description: Normal fibroblasts exposed to N-acetylmannosamine yielded lysosome-rich granular fractions loaded with free (unbound) sialic acid, whose velocity of egress increased with increasing initial loading. Fibroblast granular fractions of patients with Salla disease exhibited negligible egress of sialic acid, whether endogenous or derived from N-acetylmannosamine exposure. Salla disease represents the first disorder demonstrated to be caused by defective transport of a monosaccharide out of cellular lysosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Renlund, M -- Tietze, F -- Gahl, W A -- New York, N.Y. -- Science. 1986 May 9;232(4751):759-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3961501" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Fractionation ; Fibroblasts/drug effects/*metabolism ; Hexosamines/pharmacology ; Humans ; Lysosomes/drug effects/*metabolism ; Metabolism, Inborn Errors/*metabolism ; N-Acetylneuraminic Acid ; Sialic Acids/analysis/*metabolism ; Subcellular Fractions/analysis
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, S A -- New York, N.Y. -- Science. 1986 May 30;232(4754):1096-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17754495" target="_blank"〉PubMed〈/a〉
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  • 20
    Publication Date: 1986-11-07
    Description: Binding of antibodies to effector cells by way of receptors to their constant regions (Fc receptors) is central to the pathway that leads to clearance of antigens by the immune system. The structure and function of this important class of receptors on immune cells is addressed through the molecular characterization of Fc receptors (FcR) specific for the murine immunoglobulin G isotype. Structural diversity is encoded by two genes that by alternative splicing result in expression of molecules with highly conserved extracellular domains and different transmembrane and intracytoplasmic domains. The proteins encoded by these genes are members of the immunoglobulin supergene family, most homologous to the major histocompatibility complex molecule E beta. Functional reconstitution of ligand binding by transfection of individual FcR genes demonstrates that the requirements for ligand binding are encoded in a single gene. These studies demonstrate the molecular basis for the functional heterogeneity of FcR's, accounting for the possible transduction of different signals in response to a single ligand.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ravetch, J V -- Luster, A D -- Weinshank, R -- Kochan, J -- Pavlovec, A -- Portnoy, D A -- Hulmes, J -- Pan, Y C -- Unkeless, J C -- AI 24322/AI/NIAID NIH HHS/ -- GM 36306/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1986 Nov 7;234(4777):718-25.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2946078" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; DNA/genetics ; Gene Expression Regulation ; Histocompatibility Antigens Class II/genetics ; Immunoglobulin G ; Lymphocytes/*physiology ; Macrophages/*physiology ; Membrane Proteins ; Mice ; Protein Conformation ; *Receptors, Fc/genetics ; Receptors, IgG ; Transcription, Genetic ; Transfection
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  • 21
    Publication Date: 1986-10-24
    Description: Transformed Arabidopsis thaliana plants have been produced by a modified leaf disk transformation-regeneration method. Leaf pieces from sterilely grown plants were precultured for 2 days and inoculated with an Agrobacterium tumefaciens strain containing an avirulent Ti (tumor-inducing) plasmid with a chimeric gene encoding hygromycin resistance. After cocultivation for 2 days, the leaf pieces were placed on a medium that selects for hygromycin resistance. Shoots regenerated within 3 months and were excised, rooted, and transferred to soil. Transformation was confirmed by opine production, hygromycin resistance, and DNA blot hybridization of both primary transformants and progeny. This process for producing transgenic Arabidopsis plants should enhance the usefulness of the species for experimental biology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lloyd, A M -- Barnason, A R -- Rogers, S G -- Byrne, M C -- Fraley, R T -- Horsch, R B -- New York, N.Y. -- Science. 1986 Oct 24;234(4775):464-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17792019" target="_blank"〉PubMed〈/a〉
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Logsdon, J -- New York, N.Y. -- Science. 1986 Jul 18;233(4761):263.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737602" target="_blank"〉PubMed〈/a〉
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  • 23
    Publication Date: 1986-06-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Livingstone, D A -- New York, N.Y. -- Science. 1986 Jun 6;232(4755):1279-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17810750" target="_blank"〉PubMed〈/a〉
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neiburger, M -- New York, N.Y. -- Science. 1986 Feb 28;231(4741):1022.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17740300" target="_blank"〉PubMed〈/a〉
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  • 25
    Publication Date: 1986-02-28
    Description: Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Low, M J -- Lechan, R M -- Hammer, R E -- Brinster, R L -- Habener, J F -- Mandel, G -- Goodman, R H -- AM 01313/AM/NIADDK NIH HHS/ -- AM 30457/AM/NIADDK NIH HHS/ -- AM 31400/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1986 Feb 28;231(4741):1002-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2868526" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Recombinant/metabolism ; Genes ; Genetic Engineering ; Humans ; Immunoenzyme Techniques ; Luteinizing Hormone/metabolism ; Metallothionein/*genetics ; Mice ; Pituitary Gland, Anterior/*metabolism ; Rats ; Somatostatin/*genetics/metabolism
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  • 26
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-04-04
    Description: Meteorologists and climatologists have produced significant new data on the fluid dynamics of the atmosphere, thus allowing biologists to examine more closely the cause-effect relation between the large-scale structure of the atmosphere and the dominant patterns of global biogeography. The inability to characterize the high-frequency variability of the weather has constrained such efforts. A method that allows year-to-year patterns of weather variability to be characterized in the contexts of global warming and cooling trends is applied in a combined analysis of long-term monthly weather records and data from an ecological monitoring project in southern New Mexico. The analysis suggests a cause-effect hypothesis of recent desertification in the North American Southwest. The links between the atmosphere and the biosphere are based on the fundamentally different responses to specific weather regimes of semidesert grasses with a C(4) photosynthetic pathway and desert shrubs with a C(3) photosynthetic pathway. The hypothesis appears to be of sufficient generality to explain the complex, but well-documented, floristic changes that have occurred in the same region since the last glacial maximum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neilson, R P -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):27-34.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773996" target="_blank"〉PubMed〈/a〉
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-05-30
    Description: The 5 January 1972 announcement by President Richard Nixon that the United States would develop during the 1970's a new space transportation system-the space shuttle-has had fundamental impacts on the character of U.S. space activities. In retrospect, it can be argued that the shuttle design chosen was destined to fail to meet many of the policy objectives established for the system; the shuttle's problems in serving as the primary launch vehicle for the United States and in providing routine and cost-effective space transportation are in large part a result of the ways in which compromises were made in the 1971-72 period in order to gain White House and congressional approval to proceed with the program. The decision to develop a space shuttle is an example of a poor quality national commitment to a major technological undertaking.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Logsdon, J M -- New York, N.Y. -- Science. 1986 May 30;232(4754):1099-105.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17754497" target="_blank"〉PubMed〈/a〉
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  • 28
    Publication Date: 1986-04-18
    Description: Polyadenylated RNA isolated from senescent human diploid fibroblasts (HDF) inhibited DNA synthesis in proliferation-competent cells after microinjection, whereas polyadenylated RNA from young HDF had no inhibitory effect. Polyadenylated RNA from young cells made quiescent by removal of serum growth factors had a slight inhibitory effect on DNA synthesis. The abundance level of inhibitor messenger RNA (mRNA) from senescent cells was estimated at 0.8 and that of quiescent cells at 0.005 percent. These results demonstrate the existence of one or more antiproliferative mRNA's in nonproliferating normal human cells; these RNA's code for factors that either work antagonistically to initiators of DNA synthesis or regulate the expression of the initiators in some way. The abundance level of the inhibitory mRNA in senescent cells indicates the feasibility of developing a complementary DNA probe that will be useful in studying cell cycle control mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lumpkin, C K Jr -- McClung, J K -- Pereira-Smith, O M -- Smith, J R -- AG-04749/AG/NIA NIH HHS/ -- AG-05333/AG/NIA NIH HHS/ -- T32-CA-09197/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 18;232(4748):393-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2421407" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Division/drug effects ; *Cell Survival ; DNA/biosynthesis ; Diploidy ; Fibroblasts/*physiology ; Humans ; Oncogenes ; Poly A/*isolation & purification/pharmacology/physiology ; RNA/*isolation & purification/pharmacology/physiology ; RNA, Messenger/*isolation & purification/pharmacology/physiology
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  • 29
    Publication Date: 1986-09-12
    Description: Very long baseline interferometry measurements of baselines crossing the San Andreas fault zone in southern California have provided observational constraints on rates of elastic tectonic strain accumulation. The single site located near this fault (the Jet Propulsion Laboratory site) moves in a direction concordant with the Pacific plate motion vector but at approximately half the net rate relative to North America. This motion agrees approximately in amount with geologically determined displacement rates on the San Andreas fault alone but not with the local strike of the fault. When considered together with complementary geodetic data, these results suggest a complex relation between the short-term accumulation of elastic strain and its permanent accommodation on existing faults.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyzenga, G A -- Golombek, M P -- New York, N.Y. -- Science. 1986 Sep 12;233(4769):1181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17756870" target="_blank"〉PubMed〈/a〉
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  • 30
    Publication Date: 1986-05-09
    Description: Sulfur species in pore waters of the Great Marsh, Delaware, were analyzed seasonally by polarographic methods. The species determined (and their concentrations in micromoles per liter) included inorganic sulfides (〈/=3360), polysulfides (〈/=326), thiosulfate (〈/=104), tetrathionate (〈/=302), organic thiols (〈/=2411), and organic disulfides (〈/=139). Anticipated were bisulfide increases with depth due to sulfate reduction and subsurface sulfate excesses and pH minima, the result of a seasonal redox cycle. Unanticipated was the pervasive presence of thiols (for example, glutathione), particularly during periods of biological production. Salt marshes appear to be unique among marine systems in producing high concentrations of thiols. Polysulfides, thiosulfate, and tetrathionate also exhibited seasonal subsurface maxima. These results suggest a dynamic seasonal cycling of sulfur in salt marshes involving abiological and biological reactions and dissolved and solid sulfur species. The chemosynthetic turnover of pyrite to organic sulfur is a likely pathway for this sulfur cycling. Thus, material, chemical, and energy cycles in wetlands appear to be optimally synergistic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luther, G W 3rd -- Church, T M -- Scudlark, J R -- Cosman, M -- New York, N.Y. -- Science. 1986 May 9;232(4751):746-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17769570" target="_blank"〉PubMed〈/a〉
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macauley, M K -- Toman, M A -- New York, N.Y. -- Science. 1986 Sep 19;233(4770):1245.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17843342" target="_blank"〉PubMed〈/a〉
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, A L -- New York, N.Y. -- Science. 1986 Aug 8;233(4764):623.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17835817" target="_blank"〉PubMed〈/a〉
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  • 33
    Publication Date: 1986-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, A L -- New York, N.Y. -- Science. 1986 Oct 3;234(4772):24-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17742630" target="_blank"〉PubMed〈/a〉
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  • 34
    Publication Date: 1986-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, A L -- New York, N.Y. -- Science. 1986 Jun 20;232(4757):1496-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773498" target="_blank"〉PubMed〈/a〉
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  • 35
    Publication Date: 1986-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, A L -- New York, N.Y. -- Science. 1986 Jul 18;233(4761):280-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737612" target="_blank"〉PubMed〈/a〉
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maloney, P C -- New York, N.Y. -- Science. 1986 Nov 7;234(4777):768.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17744479" target="_blank"〉PubMed〈/a〉
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  • 37
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-09-26
    Description: Fusions of the secreted protein alkaline phosphatase to an integral cytoplasmic membrane protein of Escherichia coli showed different activities depending on where in the membrane protein the alkaline phosphatase was fused. Fusions to positions in or near the periplasmic domain led to high alkaline phosphatase activity, whereas those to positions in the cytoplasmic domain gave low activity. Analysis of alkaline phosphatase fusions to membrane proteins of unknown structure may thus be generally useful in determining their membrane topologies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manoil, C -- Beckwith, J -- New York, N.Y. -- Science. 1986 Sep 26;233(4771):1403-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3529391" target="_blank"〉PubMed〈/a〉
    Keywords: Alkaline Phosphatase/genetics ; Cell Membrane/ultrastructure ; Chromosome Deletion ; Escherichia coli/genetics ; Membrane Proteins/*genetics ; Mutation ; Plasmids ; Protein Conformation ; Recombinant Proteins/analysis
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Aug 15;233(4765):717-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17835177" target="_blank"〉PubMed〈/a〉
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  • 39
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-10-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shigematsu, I -- New York, N.Y. -- Science. 1986 Oct 10;234(4773):128.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3749896" target="_blank"〉PubMed〈/a〉
    Keywords: Follow-Up Studies ; Humans ; Japan ; *Nuclear Warfare ; *Radiation Injuries ; United States
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  • 40
    Publication Date: 1986-05-02
    Description: The development of simultaneous resistance to multiple structurally unrelated drugs is a major impediment to cancer chemotherapy. Multidrug resistance in human KB carcinoma cells selected in colchicine, vinblastine, or Adriamycin is associated with amplification of specific DNA sequences (the multidrug resistance locus, mdr1). During colchicine selection resistance is initially accompanied by elevated expression of a 4.5-kilobase mdr1 messenger RNA (mRNA) without amplification of the corresponding genomic sequences. During selection for increased levels of resistance, expression of this mRNA is increased simultaneously with amplification of mdr1 DNA. Increased expression and amplification of mdr1 sequences were also found in multidrug-resistant sublines of human leukemia and ovarian carcinoma cells. These results suggest that increased expression of mdr1 mRNA is a common mechanism for multidrug resistance in human cells. Activation of the mdr1 gene by mutations or epigenetic changes may precede its amplification during the development of resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, D W -- Fojo, A -- Chin, J E -- Roninson, I B -- Richert, N -- Pastan, I -- Gottesman, M M -- New York, N.Y. -- Science. 1986 May 2;232(4750):643-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3457471" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Colchicine/pharmacology ; Cricetinae ; Cricetulus ; DNA, Neoplasm/genetics ; Doxorubicin/pharmacology ; *Drug Resistance ; Female ; *Gene Amplification ; Humans ; Leukemia, Lymphoid/drug therapy ; Neoplasms/*drug therapy/genetics ; Nucleic Acid Hybridization ; Ovarian Neoplasms/drug therapy ; RNA, Messenger/genetics ; Vinblastine/pharmacology
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  • 41
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shurcliff, W A -- New York, N.Y. -- Science. 1986 Mar 21;231(4744):1355.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17748061" target="_blank"〉PubMed〈/a〉
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, A L -- New York, N.Y. -- Science. 1986 Apr 25;232(4749):453.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17743569" target="_blank"〉PubMed〈/a〉
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  • 43
    Publication Date: 1986-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, A L -- New York, N.Y. -- Science. 1986 Apr 11;232(4747):156-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17780803" target="_blank"〉PubMed〈/a〉
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  • 44
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, A L -- New York, N.Y. -- Science. 1986 Mar 21;231(4744):1371.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17748076" target="_blank"〉PubMed〈/a〉
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  • 45
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Mar 21;231(4744):1364-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3952488" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*economics ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States ; United States Dept. of Health and Human Services
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  • 46
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Mar 21;231(4744):1364.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3952487" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Legislation, Medical ; *National Institutes of Health (U.S.) ; United States
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  • 47
    Publication Date: 1986-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, A L -- New York, N.Y. -- Science. 1986 Mar 21;231(4744):1370-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17748075" target="_blank"〉PubMed〈/a〉
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  • 48
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Feb 21;231(4740):785-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945809" target="_blank"〉PubMed〈/a〉
    Keywords: Legislation as Topic ; National Institutes of Health (U.S.)/*economics ; United States
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Feb 21;231(4740):791.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17774072" target="_blank"〉PubMed〈/a〉
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-01-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Jan 3;231(4733):11-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3001932" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Antibodies, Viral/analysis ; Deltaretrovirus/*isolation & purification ; France ; HIV Antibodies ; Humans ; Patents as Topic/*legislation & jurisprudence ; United States
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  • 51
    Publication Date: 1986-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- Marshall, E -- New York, N.Y. -- Science. 1986 Jul 11;233(4760):145-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737280" target="_blank"〉PubMed〈/a〉
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  • 52
    Publication Date: 1986-02-21
    Description: Partial amino acid sequence analysis of a purified lymphocyte homing receptor demonstrates the presence of two amino termini, one of which corresponds precisely to the amino terminus of ubiquitin. This observation extends the province of this conserved polypeptide to the cell surface and leads to a proposed model of the receptor complex as a core polypeptide modified by glycosylation and ubiquitination. Independent antibodies to ubiquitin serve to identify additional cell surface species, an indication that ubiquitination of cell surface proteins may be more general. It is proposed that functional binding of lymphocytes to lymph node high endothelial venules might involve the ubiquitinated region of the receptor; if true, cell surface ubiquitin could play a more general role in cell-cell interaction and adhesion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Siegelman, M -- Bond, M W -- Gallatin, W M -- St John, T -- Smith, H T -- Fried, V A -- Weissman, I L -- AI 19512/AI/NIAID NIH HHS/ -- CA 09151/CA/NCI NIH HHS/ -- GM 31461/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1986 Feb 21;231(4740):823-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3003913" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Monoclonal ; Cell Movement ; Endothelium/metabolism ; Glycoproteins/metabolism/*physiology ; Glycoside Hydrolases/metabolism ; High Mobility Group Proteins/*metabolism ; Lymphocytes/*physiology ; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase ; Membrane Proteins/metabolism/*physiology ; Mice ; Molecular Weight ; Protein Processing, Post-Translational ; Receptors, Cell Surface/metabolism/*physiology ; Ubiquitins/immunology/*metabolism
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  • 53
    Publication Date: 1986-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, A L -- New York, N.Y. -- Science. 1986 Feb 7;231(4738):546-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17750963" target="_blank"〉PubMed〈/a〉
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-06-13
    Description: Synthetic diamond crystals were used as opposed anvils whose small culet surfaces were driven into contact with each other to generate high static pressures. Pressures in excess of 68 gigapascals (680 kilobars) were achieved, as determined from the fluorescence line of a ruby fragment sandwiched between the diamonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Onodera, A -- Furuno, K -- Yazu, S -- New York, N.Y. -- Science. 1986 Jun 13;232(4756):1419-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17828918" target="_blank"〉PubMed〈/a〉
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  • 55
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-03-14
    Description: The vocal organ, or syrinx, of oscine birds has two parts, each of which has generally been presumed to operate independently of the other. A significant counter-example is now demonstrated in the production of a common vocalization by the black-capped chickadee (Parus atricapillus), in which the two acoustic sources interact in a nonlinear fashion. This bird produces a sound with multiple frequency components that are heterodyne products resulting from cross-modulation between two signals, thus providing evidence that avian phonation can involve cooperative coupling between the two syringeal sources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nowicki, S -- Capranica, R R -- 5 T32 MH 15793-05/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1986 Mar 14;231(4743):1297-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945824" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birds/anatomy & histology/*physiology ; Sound Spectrography ; Vocalization, Animal/*physiology
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  • 56
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-02-21
    Description: Random structures often exhibit fractal geometry, defined in terms of the mass scaling exponent, D, the fractal dimension. The vibrational dynamics of fractal networks are expressed in terms of the exponent d, the fracton dimensionality. The eigenstates on a fractal network are spatially localized for d less than or equal to 2. The implications of fractal geometry are discussed for thermal transport on fractal networks. The electron-fracton interaction is developed, with a brief outline given for the time dependence of the electronic relaxation on fractal networks. It is suggested that amorphous or glassy materials may exhibit fractal properties at short length scales or, equivalently, at high energies. The calculations of physical properties can be used to test the fractal character of the vibrational excitations in these materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Orbach, R -- New York, N.Y. -- Science. 1986 Feb 21;231(4740):814-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17774075" target="_blank"〉PubMed〈/a〉
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  • 57
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-08-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Osterbrock, D E -- New York, N.Y. -- Science. 1986 Aug 1;233(4763):582-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17820476" target="_blank"〉PubMed〈/a〉
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  • 58
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paine, L -- New York, N.Y. -- Science. 1986 May 23;232(4753):1011-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17759287" target="_blank"〉PubMed〈/a〉
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  • 59
    Publication Date: 1986-11-14
    Description: The luciferase gene from the firefly, Photinus pyralis, was used as a reporter of gene expression by light production in transfected plant cells and transgenic plants. A complementary DNA clone of the firefly luciferase gene under the control of a plant virus promoter (cauliflower mosaic virus 35S RNA promoter) was introduced into plant protoplast cells (Daucus carota) by electroporation and into plants (Nicotiana tabacum) by use of the Agrobacterium tumefaciens tumor-inducing plasmid. Extracts from electroporated cells (24 hours after the introduction of DNA) and from transgenic plants produce light when mixed with the substrates luciferin and adenosine triphosphate. Light produced by the action of luciferase was also detected in undisrupted leaves or cells in culture from transgenic plants incubated in luciferin and in whole transgenic plants "watered" with luciferin. Although light was detected in most organs in intact, transgenic plants (leaves, stems, and roots), the pattern of luminescence appeared to reflect both the organ-specific distribution of luciferase and the pathway for uptake of luciferin through the vasculature of the plant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ow, D W -- DE Wet, J R -- Helinski, D R -- Howell, S H -- Wood, K V -- Deluca, M -- New York, N.Y. -- Science. 1986 Nov 14;234(4778):856-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17758108" target="_blank"〉PubMed〈/a〉
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  • 60
    Publication Date: 1986-07-04
    Description: Voyager 2 images of the southern hemisphere of Uranus indicate that submicrometersize haze particles and particles of a methane condensation cloud produce faint patterns in the atmosphere. The alignment of the cloud bands is similar to that of bands on Jupiter and Saturn, but the zonal winds are nearly opposite. At mid-latitudes (-70 degrees to -27 degrees ), where winds were measured, the atmosphere rotates faster than the magnetic field; however, the rotation rate of the atmosphere decreases toward the equator, so that the two probably corotate at about -20 degrees . Voyager images confirm the extremely low albedo of the ring particles. High phase angle images reveal on the order of 10(2) new ringlike features of very low optical depth and relatively high dust abundance interspersed within the main rings, as well as a broad, diffuse, low optical depth ring just inside the main rings system. Nine of the newly discovered small satellites (40 to 165 kilometers in diameter) orbit between the rings and Miranda; the tenth is within the ring system. Two of these small objects may gravitationally confine the e ring. Oberon and Umbriel have heavily cratered surfaces resembling the ancient cratered highlands of Earth's moon, although Umbriel is almost completely covered with uniform dark material, which perhaps indicates some ongoing process. Titania and Ariel show crater populations different from those on Oberon and Umbriel; these were probably generated by collisions with debris confined to their orbits. Titania and Ariel also show many extensional fault systems; Ariel shows strong evidence for the presence of extrusive material. About halfof Miranda's surface is relatively bland, old, cratered terrain. The remainder comprises three large regions of younger terrain, each rectangular to ovoid in plan, that display complex sets of parallel and intersecting scarps and ridges as well as numerous outcrops of bright and dark materials, perhaps suggesting some exotic composition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, B A -- Soderblom, L A -- Beebe, R -- Bliss, D -- Boyce, J M -- Brahic, A -- Briggs, G A -- Brown, R H -- Collins, S A -- Cook, A F 2nd -- Croft, S K -- Cuzzi, J N -- Danielson, G E -- Davies, M E -- Dowling, T E -- Godfrey, D -- Hansen, C J -- Harris, C -- Hunt, G E -- Ingersoll, A P -- Johnson, T V -- Krauss, R J -- Masursky, H -- Morrison, D -- Owen, T -- Plescia, J B -- Pollack, J B -- Porco, C C -- Rages, K -- Sagan, C -- Shoemaker, E M -- Sromovsky, L A -- Stoker, C -- Strom, R G -- Suomi, V E -- Synnott, S P -- Terrile, R J -- Thomas, P -- Thompson, W R -- Veverka, J -- New York, N.Y. -- Science. 1986 Jul 4;233(4759):43-64.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812889" target="_blank"〉PubMed〈/a〉
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  • 61
    Publication Date: 1986-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, M G -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):112-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17774012" target="_blank"〉PubMed〈/a〉
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  • 62
    Publication Date: 1986-04-18
    Description: The vector helium magnetometer on the International Cometary Explorer observed the magnetic fields induced by the interaction of comet Giacobini-Zinner with the solar wind. A magnetic tail was penetrated approximately 7800 kilometers downstream from the comet and was found to be 10(4) kilometers wide. It consisted of two lobes, containing oppositely directed fields with strengths up to 60 nanoteslas, separated by a plasma sheet approximately 10(3)kilometers thick containing a thin current sheet. The magnetotail was enclosed in an extended ionosheath characterized by intense hydromagnetic turbulene and interplanetary fields draped around the comet. A distant bow wave, which may or may not have been a bow shock, was observed at both edges of the ionosheath. Weak turbulence was observed well upstream of the bow wave.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, E J -- Tsurutani, B T -- Slvain, J A -- Jones, D E -- Siscoe, G L -- Mendis, D A -- New York, N.Y. -- Science. 1986 Apr 18;232(4748):382-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17792150" target="_blank"〉PubMed〈/a〉
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  • 63
    Publication Date: 1986-04-04
    Description: Cleavage of phosphatidylinositol 4,5-bisphosphate by phospholipase C results in the production of two important second messengers: inositol-1,4,5-trisphosphate and 1,2-diacylglycerol. Although several receptors promote this cleavage, the molecular details of phospholipase C activation have remained unresolved. In this study, occupancy of a Ca2+-mobilizing receptor, the oligopeptide chemoattractant receptor on human polymorphonuclear leukocyte plasma membranes, was found to lead to the activation of a guanine nucleotide regulatory (N) protein by guanosine 5'-triphosphate. The activated N protein then stimulated a polyphosphoinositide-specific phospholipase C by reducing the Ca2+ requirement for expression of this activity from superphysiological to normal intracellular concentrations. Therefore, the N protein-mediated activation of phospholipase C may be a key step in the pathway of cellular activation by chemoattractants and certain other hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, C D -- Cox, C C -- Snyderman, R -- 5PO1-CA-29589-04/CA/NCI NIH HHS/ -- 5RO1 DEO 3738-12/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):97-100.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3006254" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/blood ; Cell Membrane/metabolism ; Enzyme Activation ; GTP-Binding Proteins/*metabolism ; Humans ; Kinetics ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Neutrophils/metabolism ; Phosphatidylinositols/*blood ; Phosphorus Radioisotopes ; Ribonucleotides/blood ; Type C Phospholipases/*blood
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  • 64
    Publication Date: 1986-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1986 Jul 4;233(4759):15-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812879" target="_blank"〉PubMed〈/a〉
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  • 65
    Publication Date: 1986-07-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1986 Jul 25;233(4762):409-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17794557" target="_blank"〉PubMed〈/a〉
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  • 66
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rourke, F E -- New York, N.Y. -- Science. 1986 Nov 7;234(4777):766-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17744476" target="_blank"〉PubMed〈/a〉
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  • 67
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-01-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robinson, A L -- New York, N.Y. -- Science. 1986 Jan 17;231(4735):218.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17769641" target="_blank"〉PubMed〈/a〉
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  • 68
    Publication Date: 1986-10-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petit, C -- New York, N.Y. -- Science. 1986 Oct 10;234(4773):145-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17746472" target="_blank"〉PubMed〈/a〉
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  • 69
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-05-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Phillips, O M -- New York, N.Y. -- Science. 1986 May 9;232(4751):779.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17769578" target="_blank"〉PubMed〈/a〉
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  • 70
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickett, B H -- New York, N.Y. -- Science. 1986 Apr 11;232(4747):145.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17780793" target="_blank"〉PubMed〈/a〉
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  • 71
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-03-14
    Description: The pattern of connections between the retina and midbrain has been determined with electrophysiological and neuroanatomical methods in bats representing the two major subdivisions of the Chiroptera. Megachiropteran fruit bats (megabats), Pteropus spp., were found to have an advanced retinotectal pathway with a vertical hemidecussation of the kind previously found only in primates. In contrast, the microchiropteran bat Macroderma gigas has the "ancestral" or symplesiomorphous pattern of retinotectal connections so far found in all vertebrates except primates. In addition to linking primates and megachiropteran bats, these findings suggest that flight may have evolved twice among the mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pettigrew, J D -- New York, N.Y. -- Science. 1986 Mar 14;231(4743):1304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945827" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Chiroptera/*anatomy & histology/physiology ; Electrophysiology ; Eye/innervation ; Mesencephalon/anatomy & histology/physiology ; Primates/physiology ; Retina/physiology ; Sciuridae ; Superior Colliculi/physiology ; Tupaiidae ; Visual Pathways/*anatomy & histology/physiology
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  • 72
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenzweig, R M -- New York, N.Y. -- Science. 1986 Jun 20;232(4757):1508-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3715459" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; *Research Support as Topic ; United States ; Universities/*economics
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  • 73
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-09-26
    Description: Some Cnemidophorus exsanguis have mitochondrial DNA's (mtDNA's) that are 22.2 kilobases (kb) in size, whereas most have mtDNA's of 17.4 kb. Restriction site mapping, DNA transfer hybridization experiments, and electron microscopy show that the size increment stems from the tandem duplication of a 4.8-kb region that includes regulatory sequences and transfer and ribosomal RNA genes. This observation is notable in that sequences outside of the control region are involved in major length variation. Besides revealing a novel form of mtDNA evolution in animals, these duplications provide a useful system for investigating the molecular and evolutionary biology of animal mtDNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moritz, C -- Brown, W M -- GM30144/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1986 Sep 26;233(4771):1425-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3018925" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; DNA Restriction Enzymes ; DNA, Mitochondrial/*genetics ; Lizards ; Microscopy, Electron ; Nucleic Acid Conformation ; Nucleic Acid Hybridization ; RNA, Ribosomal/*genetics ; Repetitive Sequences, Nucleic Acid
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-07-18
    Description: Organic chemistry in present day Japan, which has developed from early interest in natural products chemistry, now includes total synthesis, physical organic chemistry, synthetic methods, and organometallic chemistry. In this article, the current state of Japanese organic chemistry is briefly reviewed and a representative aspect of today's organic chemistry-exploration of new synthetic methodology-is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mukaiyama, T -- New York, N.Y. -- Science. 1986 Jul 18;233(4761):318-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17737618" target="_blank"〉PubMed〈/a〉
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  • 75
    Publication Date: 1986-06-20
    Description: Gaseous, neutral H(2)O was detected in the coma of comet Halley on 22.1 and 24.1 December 1985 Universal Time. Nine spectral lines of thev(3) band (2.65 micrometers) were found by means of a Fourier transform spectrometer (lambda/triangle uplambda approximately 10(5)) on the NASA-Kuiper Airborne Observatory. The water production rate was approximately 6 x 10(28) molecules per second on 22.1 December and 1.7 x 10(29) molecules per second on 24.1 December UT. The numbers of spectral lines and their intensities are in accord with nonthermal-equilibrium cometary models. Rotational populations are derived from the observed spectral line intensities and excitation conditions are discussed. The ortho-para ratio was found to be 2.66+/-0.13, corresponding to a nuclear-spin temperature of 32 K (+5 K, -2 K), possibly indicating that the observed water vapor originated from a low-temperature ice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mumma, M J -- Weaver, H A -- Larson, H P -- Davis, D S -- Williams, M -- New York, N.Y. -- Science. 1986 Jun 20;232(4757):1523-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773501" target="_blank"〉PubMed〈/a〉
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  • 76
    Publication Date: 1986-08-22
    Description: Continuous measurement and imaging of the intracellular free calcium ion concentration ([Ca2+]i) of mitotic and interphase PtK1 cells was accomplished with the new fluorescent Ca2+ indicator fura-2. No statistically significant difference between basal [Ca2+]i of interphase and mitotic cells was detected. However, mitotic cells showed a rapid elevation of [Ca2+]i from basal levels of 130 nM to 500 to 800 nM at the metaphase-anaphase transition. The [Ca2+]i transient was brief, lasting approximately 20 seconds and the elevated [Ca2+]i appeared uniformly distributed over the entire spindle and central region of the cell. The close temporal association of the [Ca2+]i transient with the onset of anaphase suggests that calcium may have a signaling role in this event.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poenie, M -- Alderton, J -- Steinhardt, R -- Tsien, R -- EY04372/EY/NEI NIH HHS/ -- GM31004/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1986 Aug 22;233(4766):886-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3755550" target="_blank"〉PubMed〈/a〉
    Keywords: *Anaphase ; Animals ; Benzofurans ; Calcium/*metabolism ; Cell Line ; Fluorescent Dyes ; Fura-2 ; Mitosis
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  • 77
    Publication Date: 1986-03-07
    Description: Glycerol-derived membrane lipids are essentially absent in the thermophilic bacterium Thermomicrobium roseum. A series of straight chain and internally methyl-branched 1,2-diols of carbon numbers C(18) to C(23) were found to replace glycerolipids in this bacterium. Fatty acids were present but were ester-linked to the diols or amide-linked to polar heads groups and not to glycerol. This thermophile has evolved the integration of diols as a novel approach for the construction of its cytoplasmic membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pond, J L -- Langworthy, T A -- Holzer, G -- New York, N.Y. -- Science. 1986 Mar 7;231(4742):1134-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17818542" target="_blank"〉PubMed〈/a〉
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  • 78
    Publication Date: 1986-08-01
    Description: Solemya reidi, a gutless clam found in sulfide-rich habitats, contains within its gills bacterial symbionts thought to oxidize sulfur compounds and provide a reduced carbon food source to the clam. However, the initial step or steps in sulfide oxidation occur in the animal tissue, and mitochondria isolated from both gill and symbiont-free foot tissue of the clam coupled the oxidation of sulfide to oxidative phosphorylation [adenosine triphosphate (ATP) synthesis]. The ability of Solmya reidi to exploit directly the energy in sulfide for ATP synthesis is unprecedented, and suggests that sulfide-habitat animals that lack bacterial symbionts may also use sulfide as an inorganic energy source.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Powell, M A -- Somero, G N -- New York, N.Y. -- Science. 1986 Aug 1;233(4763):563-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17820467" target="_blank"〉PubMed〈/a〉
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  • 79
    Publication Date: 1986-09-19
    Description: WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses. They prevent the pH-mediated uncoating of the viral RNA. The compounds consist of a 3-methylisoxazole group that inserts itself into the hydrophobic interior of the VP1 beta-barrel, a connecting seven-membered aliphatic chain, and a 4-oxazolinylphenoxy group (OP) that covers the entrance to an ion channel in the floor of the "canyon." Viral disassembly may be inhibited by preventing the collapse of the VP1 hydrophobic pocket or by blocking the flow of ions into the virus interior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, T J -- Kremer, M J -- Luo, M -- Vriend, G -- Arnold, E -- Kamer, G -- Rossmann, M G -- McKinlay, M A -- Diana, G D -- Otto, M J -- New York, N.Y. -- Science. 1986 Sep 19;233(4770):1286-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3018924" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/metabolism/*pharmacology ; Binding Sites ; Chemical Phenomena ; Chemistry ; Humans ; Isoxazoles/metabolism/pharmacology ; Poliovirus/drug effects/metabolism ; Rhinovirus/*drug effects/metabolism ; X-Ray Diffraction
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sokal, M M -- New York, N.Y. -- Science. 1986 May 2;232(4750):664-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17781423" target="_blank"〉PubMed〈/a〉
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  • 81
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-10-10
    Description: Traditionally, economics has been considered a nonexperimental science. In the last quarter century experimental methods have become a growing part of the economist's effort to more fully understand how individual motivation, individual information, and exchange rules relate to market outcomes in different institutions. Empirical support has been found in a wide variety of different experiments for the theoretical proposition that markets serve to aggregate the dispersed information of individuals to produce wealth-creating outcomes for society. A number of different experiments are presented to illustrate the type of questions addressed, including some in which the process is governed by political institutions such as majority rule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, V L -- New York, N.Y. -- Science. 1986 Oct 10;234(4773):167-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17746477" target="_blank"〉PubMed〈/a〉
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  • 82
    Publication Date: 1986-03-28
    Description: The genome of the human T-lymphotropic virus type III (HTLV-III/LAV) has the potential to encode at least three polypeptides in addition to those encoded by the gag, pol, and env genes. In this study, the product of the sor (short open reading frame) region, which overlaps the 3' end of the pol gene, was found to be a protein with a molecular weight of 23,000. An assay was developed for testing the ability of cloned HTLV-III proviruses to produce viruses cytopathic for T4+ lymphocytes. In the cell line used, C8166, neither the HTLV-III sor gene product nor the complete 3'-orf gene product were necessary for the replication or cytopathic effects of the HTLV-III.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sodroski, J -- Goh, W C -- Rosen, C -- Tartar, A -- Portetelle, D -- Burny, A -- Haseltine, W -- CA07580/CA/NCI NIH HHS/ -- CA40658/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1986 Mar 28;231(4745):1549-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3006244" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cytopathogenic Effect, Viral ; Deltaretrovirus/*genetics/pathogenicity ; *Genes, Viral ; Humans ; Retroviridae Proteins/genetics ; T-Lymphocytes/microbiology ; *Virus Replication
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  • 83
    Publication Date: 1986-04-04
    Description: Experiments were conducted to isolate and characterize the gene and gene product of a human hematopoietic colony-stimulating factor with pluripotent biological activities. This factor has the ability to induce differentiation of a murine myelomonocytic leukemia cell line WEHI-3B(D+) and cells from patients with newly diagnosed acute nonlymphocytic leukemia (ANLL). A complementary DNA copy of the gene encoding a pluripotent human granulocyte colony-stimulating factor (hG-CSF) was cloned and expressed in Escherichia coli. The recombinant form of hG-CSF is capable of supporting neutrophil proliferation in a CFU-GM assay. In addition, recombinant hG-CSF can support early erythroid colonies and mixed colony formation. Competitive binding studies done with 125I-labeled hG-CSF and cell samples from two patients with newly diagnosed human leukemias as well as WEHI-3B(D+) cells showed that one of the human leukemias (ANLL, classified as M4) and the WEHI-3B(D+) cells have receptors for hG-CSF. Furthermore, the murine WEHI-3B(D+) cells and human leukemic cells classified as M2, M3, and M4 were induced by recombinant hG-CSF to undergo terminal differentiation to macrophages and granulocytes. The secreted form of the protein produced by the bladder carcinoma cell line 5637 was found to be O-glycosylated and to have a molecular weight of 19,600.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Souza, L M -- Boone, T C -- Gabrilove, J -- Lai, P H -- Zsebo, K M -- Murdock, D C -- Chazin, V R -- Bruszewski, J -- Lu, H -- Chen, K K -- CA00966/CA/NCI NIH HHS/ -- CA20194/CA/NCI NIH HHS/ -- CA32516/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):61-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2420009" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/drug effects ; Cell Line ; Colony-Forming Units Assay ; Colony-Stimulating Factors/genetics/*pharmacology ; DNA/metabolism ; Escherichia coli/genetics ; Genes ; Granulocyte Colony-Stimulating Factor ; Granulocytes/*physiology ; Humans ; Leukemia/*pathology ; Leukemia, Myeloid/pathology ; Mice ; Plasmids ; Recombinant Proteins/*pharmacology
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sprangers, M T -- New York, N.Y. -- Science. 1986 Feb 7;231(4738):536.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17750955" target="_blank"〉PubMed〈/a〉
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-12-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saavedra, R A -- New York, N.Y. -- Science. 1986 Dec 19;234(4783):1589.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3787266" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Histones/*metabolism ; Metals/*metabolism
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  • 86
    Publication Date: 1986-05-23
    Description: Electrical stimulation of fibers in the stratum radiatum causes an excitatory postsynaptic potential in CA1 neurons of the hippocampus. Other excitatory inputs to or direct depolarization of these CA1 neurons during stimulation of the stratum radiatum caused a subsequent increase in the excitatory postsynaptic potential. This enhancement was characterized as a brief potentiation (2 to 3 minutes, similar to posttetanic potentiation) and a long-term potentiation (presumed to be involved in learning and memory). These potentiations are probably induced by an interaction of the postsynaptic cell or other presynaptic terminals with the test presynaptic terminals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sastry, B R -- Goh, J W -- Auyeung, A -- New York, N.Y. -- Science. 1986 May 23;232(4753):988-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3010459" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; Calcium/physiology ; Conditioning (Psychology)/physiology ; Electric Stimulation ; Hippocampus/*physiology ; In Vitro Techniques ; Learning/physiology ; Membrane Potentials ; Rats ; Synapses/physiology ; Synaptic Transmission
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  • 87
    Publication Date: 1986-12-12
    Description: Recombinant retroviruses containing the complete genomic human beta globin gene (under the control of its own promoter) and the bacterial neomycin phosphotransferase gene (under the control of the normal or enhancerless viral promoter) were used to derive transgenic mouse strains by infection of preimplantation embryos. Expression of the beta globin gene in hematopoietic tissues was observed in all transgenic strains. In addition, one strain showed ectopic expression of beta globin in the same tissues that also expressed high levels of RNA from the viral promoter. It is likely that expression from the long terminal repeat (LTR), in contrast to expression from the internal promoter, is dependent on the site of integration. Thus, retroviral vectors can be used for tissue-specific expression of foreign genes in transgenic mice, as well as for the identification of loci that allow developmental activation of a provirus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soriano, P -- Cone, R D -- Mulligan, R C -- Jaenisch, R -- HD-19105/HD/NICHD NIH HHS/ -- P01-CA38497/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1986 Dec 12;234(4782):1409-13.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3024318" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gene Expression Regulation ; Globins/genetics ; Humans ; Kanamycin Kinase ; Mice/genetics ; Phosphotransferases/genetics ; Promoter Regions, Genetic ; RNA, Viral/immunology ; Repetitive Sequences, Nucleic Acid ; Retroviridae/*genetics
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-11-28
    Description: The concentrations of enzyme sites in cells are usually higher than the concentrations of cognate intermediary metabolites. Therefore metabolic pathways or substantial segments of pathways may proceed by the direct transfer of metabolites from one enzyme site to the next by means of enzyme-enzyme complex formation. This mechanism of metabolite transfer differs from that usually assumed where dissociation and random diffusion of metabolite through the aqueous environment is responsible for the transfer to the next enzyme site. Since the direct transfer mechanism does not involve the aqueous environment, the energetics of metabolite interconversion can differ from expectations based on aqueous solution data. Evidence is summarized suggesting that metabolite is transformed and transferred with equal facility everywhere in the direct transfer pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Srivastava, D K -- Bernhard, S A -- GM10451/GM/NIGMS NIH HHS/ -- GM37056/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1986 Nov 28;234(4780):1081-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3775377" target="_blank"〉PubMed〈/a〉
    Keywords: Enzymes/metabolism ; Kinetics ; Metabolism ; Multienzyme Complexes/biosynthesis/*metabolism ; NAD/metabolism
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  • 89
    Publication Date: 1986-04-18
    Description: T-cell receptors bind antigens only when the antigens are exposed on the cell surface. This can be studied best in the interaction of cytolytic T lymphocytes (CTL) with target cells because the recognition and binding event can be separated from the lytic phase. Studies with CTL clones specific for HLA-A2 and HLA-B7 demonstrated that conjugates of CTL's and target cells can be formed in the absence of specific antigen recognition. Furthermore, T-cell receptor and target antigen cannot interact unless there is conjugate formation. This indicates that nonspecific conjugate formation between CTL's and target cells precedes the recognition of specific antigen by the T-cell receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spits, H -- van Schooten, W -- Keizer, H -- van Seventer, G -- van de Rijn, M -- Terhorst, C -- de Vries, J E -- AI-15066/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 18;232(4748):403-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3485822" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal/immunology ; Cell Adhesion ; Clone Cells ; HLA Antigens/immunology ; HLA-A2 Antigen ; HLA-B7 Antigen ; Humans ; Isoantigens/*immunology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes, Cytotoxic/*immunology
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  • 90
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-11-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Nov 14;234(4778):815.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17758095" target="_blank"〉PubMed〈/a〉
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  • 91
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Aug 8;233(4764):617-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17835814" target="_blank"〉PubMed〈/a〉
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Nov 7;234(4777):661-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3775357" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; Humans ; Research Support as Topic ; United States
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  • 93
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Aug 8;233(4764):616-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17835813" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
    Publication Date: 1986-02-07
    Description: Strain accumulation during the 1980-85 interval has been measured by means of trilateration surveys in the Shumagin and Yakataga seismic gaps, which are the two regions identified as the most likely sites for the next great thrust earthquakes along the Alaska-Aleutian arc. No significant strain accumulation was detected in the Shumagin gap, but experience at similar subduction zones and simple models of the subduction process suggest that a measurable amount of strain should have accumulated. The most likely explanation of the observation is that subduction there is either aseismic or episodic. The strain accumulation measured in the Yakataga gap is consistent with that expected for the plate convergence rate, although the direction of maximum compression may suggest a somewhat more oblique convergence than expected.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savage, J C -- Lisowski, M -- Prescott, W H -- New York, N.Y. -- Science. 1986 Feb 7;231(4738):585-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17750970" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-03-07
    Description: The year 1970 has been suggested as a starting date for the "third age of quantum chemistry," in which theory takes on not only qualitative but also quantitative value. In fact, each of the years 1960, 1970, 1972, and 1977 is of historical value in the unraveling of the structure and energetics of the CH(2) molecule, methylene. What took place for methylene, namely the establishment of credibility for theory, has subsequently taken place for many other molecules. Three important roles for quantitative theory are outlined: (i) theory precedes experiment; (ii) theory overturns experiment, as resolved by later experiments; and (iii) theory and experiment work together to gain insight that is afforded independently to neither. Several examples from each of the three classes are given.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schaefer, H F 3rd -- New York, N.Y. -- Science. 1986 Mar 7;231(4742):1100-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17818539" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-03-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Mar 7;231(4742):1063.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3003918" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*diagnosis ; Antibodies, Viral/*analysis ; Deltaretrovirus/*immunology ; Humans ; Methods
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
    Publication Date: 1986-01-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1986 Jan 17;231(4735):211.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17769632" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-09-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- Dickson, D -- New York, N.Y. -- Science. 1986 Sep 12;233(4769):1141-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3738526" target="_blank"〉PubMed〈/a〉
    Keywords: *Accidents ; *Nuclear Reactors ; Ukraine
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  • 99
    Publication Date: 1986-06-27
    Description: Because availability of resources often limits seed or fruit set, increased visits by pollinators may not always lead to increases in maternal reproduction. This observation has led evolutionary biologists to hypothesize that a plant's ability to attract pollinators may have its primary impact on male fitness achieved through the fertlization of ovules. This interpretation of angiosperm reproductive ecology is supported by field experiments. Pollinating insects strongly discriminated between two Mendelian petal-color morphs in Raphanus raphanistrum, a widespread, self-incompatible crucifer. In experimental populations composed of petal-color homozygotes. color discrimination by naturally occurring pollinators had no statistically significant effect on relative maternal function (fruit and seed production) in the two morphs. In contrast, yellow-flowered individuals were far more successful as fathers (pollen donors) than were the less visited whites. These results suggest that the evolution of floral signals such as petal color may be driven primarily by selection on male function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanton, M L -- Snow, A A -- Handel, S N -- New York, N.Y. -- Science. 1986 Jun 27;232(4758):1625-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812141" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1986-10-31
    Description: When pulsed, ultraviolet laser radiation falls on the surface of an organic polymer or biological tissue, the material at the surface is spontaneously etched away to a depth of 0.1 to several micrometers. In the process, the depth of etching is controlled by the width of the pulse and the fluence of the laser, and there is no detectable thermal damage to the substrate. The material that is removed by etching consists of products ranging from atoms to small fragments of the polymer. They are ejected at supersonic velocities. This dry photoetching technique is useful in patterning polymer films. It is also under serious investigation in several areas in surgery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Srinivasan, R -- New York, N.Y. -- Science. 1986 Oct 31;234(4776):559-65.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3764428" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta/surgery ; Cornea/surgery ; Humans ; *Laser Therapy ; *Lasers ; Polymers/*radiation effects ; Rabbits ; Ultraviolet Rays
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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