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  • 1
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    The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration (2016)
    Springer Nature
    Details
    Publication Date: 2016-04-08
    Description: The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration Cell Death and Disease 7, e2184 (April 2016). doi:10.1038/cddis.2016.91 Authors: A E Hall, W-T Lu, J D Godfrey, A V Antonov, C Paicu, S Moxon, T Dalmay, A Wilczynska, P A J Muller & M Bushell
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    JAK2V617F induces replication fork stalling in MPN [Medical Sciences] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-10-22
    Description: Cancers result from the accumulation of genetic lesions, but the cellular consequences of driver mutations remain unclear, especially during the earliest stages of malignancy. The V617F mutation in the JAK2 non-receptor tyrosine kinase (JAK2V617F) is present as an early somatic event in most patients with myeloproliferative neoplasms (MPNs), and the...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Voyager 2 at neptune: imaging science results (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-12-15
    Description: Voyager 2 images of Neptune reveal a windy planet characterized by bright clouds of methane ice suspended in an exceptionally clear atmosphere above a lower deck of hydrogen sulfide or ammonia ices. Neptune's atmosphere is dominated by a large anticyclonic storm system that has been named the Great Dark Spot (GDS). About the same size as Earth in extent, the GDS bears both many similarities and some differences to the Great Red Spot of Jupiter. Neptune's zonal wind profile is remarkably similar to that of Uranus. Neptune has three major rings at radii of 42,000, 53,000, and 63,000 kilometers. The outer ring contains three higher density arc-like segments that were apparently responsible for most of the ground-based occultation events observed during the current decade. Like the rings of Uranus, the Neptune rings are composed of very dark material; unlike that of Uranus, the Neptune system is very dusty. Six new regular satellites were found, with dark surfaces and radii ranging from 200 to 25 kilometers. All lie inside the orbit of Triton and the inner four are located within the ring system. Triton is seen to be a differentiated body, with a radius of 1350 kilometers and a density of 2.1 grams per cubic centimeter; it exhibits clear evidence of early episodes of surface melting. A now rigid crust of what is probably water ice is overlain with a brilliant coating of nitrogen frost, slightly darkened and reddened with organic polymer material. Streaks of organic polymer suggest seasonal winds strong enough to move particles of micrometer size or larger, once they become airborne. At least two active plumes were seen, carrying dark material 8 kilometers above the surface before being transported downstream by high level winds. The plumes may be driven by solar heating and the subsequent violent vaporization of subsurface nitrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, B A -- Soderblom, L A -- Banfield, D -- Barnet, C -- Basilevsky, A T -- Beebe, R F -- Bollinger, K -- Boyce, J M -- Brahic, A -- Briggs, G A -- Brown, R H -- Chyba, C -- Collins, S A -- Colvin, T -- Cook, A F 2nd -- Crisp, D -- Croft, S K -- Cruikshank, D -- Cuzzi, J N -- Danielson, G E -- Davies, M E -- De Jong, E -- Dones, L -- Godfrey, D -- Goguen, J -- Grenier, I -- Haemmerle, V R -- Hammel, H -- Hansen, C J -- Helfenstein, C P -- Howell, C -- Hunt, G E -- Ingersoll, A P -- Johnson, T V -- Kargel, J -- Kirk, R -- Kuehn, D I -- Limaye, S -- Masursky, H -- McEwen, A -- Morrison, D -- Owen, T -- Owen, W -- Pollack, J B -- Porco, C C -- Rages, K -- Rogers, P -- Rudy, D -- Sagan, C -- Schwartz, J -- Shoemaker, E M -- Showalter, M -- Sicardy, B -- Simonelli, D -- Spencer, J -- Sromovsky, L A -- Stoker, C -- Strom, R G -- Suomi, V E -- Synott, S P -- Terrile, R J -- Thomas, P -- Thompson, W R -- Verbiscer, A -- Veverka, J -- New York, N.Y. -- Science. 1989 Dec 15;246(4936):1422-49.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17755997" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in extreme parasitism (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-12-15
    Description: Powdery mildews are phytopathogens whose growth and reproduction are entirely dependent on living plant cells. The molecular basis of this life-style, obligate biotrophy, remains unknown. We present the genome analysis of barley powdery mildew, Blumeria graminis f.sp. hordei (Blumeria), as well as a comparison with the analysis of two powdery mildews pathogenic on dicotyledonous plants. These genomes display massive retrotransposon proliferation, genome-size expansion, and gene losses. The missing genes encode enzymes of primary and secondary metabolism, carbohydrate-active enzymes, and transporters, probably reflecting their redundancy in an exclusively biotrophic life-style. Among the 248 candidate effectors of pathogenesis identified in the Blumeria genome, very few (less than 10) define a core set conserved in all three mildews, suggesting that most effectors represent species-specific adaptations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spanu, Pietro D -- Abbott, James C -- Amselem, Joelle -- Burgis, Timothy A -- Soanes, Darren M -- Stuber, Kurt -- Ver Loren van Themaat, Emiel -- Brown, James K M -- Butcher, Sarah A -- Gurr, Sarah J -- Lebrun, Marc-Henri -- Ridout, Christopher J -- Schulze-Lefert, Paul -- Talbot, Nicholas J -- Ahmadinejad, Nahal -- Ametz, Christian -- Barton, Geraint R -- Benjdia, Mariam -- Bidzinski, Przemyslaw -- Bindschedler, Laurence V -- Both, Maike -- Brewer, Marin T -- Cadle-Davidson, Lance -- Cadle-Davidson, Molly M -- Collemare, Jerome -- Cramer, Rainer -- Frenkel, Omer -- Godfrey, Dale -- Harriman, James -- Hoede, Claire -- King, Brian C -- Klages, Sven -- Kleemann, Jochen -- Knoll, Daniela -- Koti, Prasanna S -- Kreplak, Jonathan -- Lopez-Ruiz, Francisco J -- Lu, Xunli -- Maekawa, Takaki -- Mahanil, Siraprapa -- Micali, Cristina -- Milgroom, Michael G -- Montana, Giovanni -- Noir, Sandra -- O'Connell, Richard J -- Oberhaensli, Simone -- Parlange, Francis -- Pedersen, Carsten -- Quesneville, Hadi -- Reinhardt, Richard -- Rott, Matthias -- Sacristan, Soledad -- Schmidt, Sarah M -- Schon, Moritz -- Skamnioti, Pari -- Sommer, Hans -- Stephens, Amber -- Takahara, Hiroyuki -- Thordal-Christensen, Hans -- Vigouroux, Marielle -- Wessling, Ralf -- Wicker, Thomas -- Panstruga, Ralph -- BB/E0009831/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/E002803/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/H001948/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2010 Dec 10;330(6010):1543-6. doi: 10.1126/science.1194573.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Life Sciences, Imperial College London, London, UK. p.spanu@imperial.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21148392" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Ascomycota/*genetics/growth & development/metabolism/pathogenicity ; Carbohydrate Metabolism ; Carrier Proteins/genetics/metabolism ; Enzymes/genetics/metabolism ; Evolution, Molecular ; Fungal Proteins/chemistry/genetics/metabolism ; *Gene Deletion ; *Genes, Fungal ; *Genome, Fungal ; Hordeum/*microbiology ; Host-Pathogen Interactions/genetics ; Metabolic Networks and Pathways/genetics ; Molecular Sequence Annotation ; Plant Diseases/*microbiology ; Retroelements ; Sequence Analysis, DNA ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-06
    Description: MicroRNAs (miRNAs) control gene expression through both translational repression and degradation of target messenger RNAs (mRNAs). However, the interplay between these processes and the precise molecular mechanisms involved remain unclear. Here, we show that translational inhibition is the primary event required for mRNA degradation. Translational inhibition depends on miRNAs impairing the function of the eIF4F initiation complex. We define the RNA helicase eIF4A2 as the key factor of eIF4F through which miRNAs function. We uncover a correlation between the presence of miRNA target sites in the 3' untranslated region (3'UTR) of mRNAs and secondary structure in the 5'UTR and show that mRNAs with unstructured 5'UTRs are refractory to miRNA repression. These data support a linear model for miRNA-mediated gene regulation in which translational repression via eIF4A2 is required first, followed by mRNA destabilization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meijer, H A -- Kong, Y W -- Lu, W T -- Wilczynska, A -- Spriggs, R V -- Robinson, S W -- Godfrey, J D -- Willis, A E -- Bushell, M -- MC_UP_A600_1023/Medical Research Council/United Kingdom -- MC_UP_A600_1024/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2013 Apr 5;340(6128):82-5. doi: 10.1126/science.1231197.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23559250" target="_blank"〉PubMed〈/a〉
    Keywords: Eukaryotic Initiation Factor-4A/*biosynthesis ; *Gene Expression Regulation ; HEK293 Cells ; HeLa Cells ; Humans ; MicroRNAs/*metabolism ; *Protein Biosynthesis ; *RNA Stability ; RNA, Messenger/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Voyager 2 in the uranian system: imaging science results (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-04
    Description: Voyager 2 images of the southern hemisphere of Uranus indicate that submicrometersize haze particles and particles of a methane condensation cloud produce faint patterns in the atmosphere. The alignment of the cloud bands is similar to that of bands on Jupiter and Saturn, but the zonal winds are nearly opposite. At mid-latitudes (-70 degrees to -27 degrees ), where winds were measured, the atmosphere rotates faster than the magnetic field; however, the rotation rate of the atmosphere decreases toward the equator, so that the two probably corotate at about -20 degrees . Voyager images confirm the extremely low albedo of the ring particles. High phase angle images reveal on the order of 10(2) new ringlike features of very low optical depth and relatively high dust abundance interspersed within the main rings, as well as a broad, diffuse, low optical depth ring just inside the main rings system. Nine of the newly discovered small satellites (40 to 165 kilometers in diameter) orbit between the rings and Miranda; the tenth is within the ring system. Two of these small objects may gravitationally confine the e ring. Oberon and Umbriel have heavily cratered surfaces resembling the ancient cratered highlands of Earth's moon, although Umbriel is almost completely covered with uniform dark material, which perhaps indicates some ongoing process. Titania and Ariel show crater populations different from those on Oberon and Umbriel; these were probably generated by collisions with debris confined to their orbits. Titania and Ariel also show many extensional fault systems; Ariel shows strong evidence for the presence of extrusive material. About halfof Miranda's surface is relatively bland, old, cratered terrain. The remainder comprises three large regions of younger terrain, each rectangular to ovoid in plan, that display complex sets of parallel and intersecting scarps and ridges as well as numerous outcrops of bright and dark materials, perhaps suggesting some exotic composition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, B A -- Soderblom, L A -- Beebe, R -- Bliss, D -- Boyce, J M -- Brahic, A -- Briggs, G A -- Brown, R H -- Collins, S A -- Cook, A F 2nd -- Croft, S K -- Cuzzi, J N -- Danielson, G E -- Davies, M E -- Dowling, T E -- Godfrey, D -- Hansen, C J -- Harris, C -- Hunt, G E -- Ingersoll, A P -- Johnson, T V -- Krauss, R J -- Masursky, H -- Morrison, D -- Owen, T -- Plescia, J B -- Pollack, J B -- Porco, C C -- Rages, K -- Sagan, C -- Shoemaker, E M -- Sromovsky, L A -- Stoker, C -- Strom, R G -- Suomi, V E -- Synnott, S P -- Terrile, R J -- Thomas, P -- Thompson, W R -- Veverka, J -- New York, N.Y. -- Science. 1986 Jul 4;233(4759):43-64.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812889" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    1H-NMR metabolomic study of whole blood from hatchling loggerhead sea turtles (Caretta caretta) exposed to crude oil and/or Corexit (2017)
    Royal Society
    Details
    Publication Date: 2017-11-23
    Description: We used proton nuclear magnetic resonance spectroscopy ( 1 H-NMR) to evaluate metabolic impacts of environmentally relevant crude oil and Corexit exposures on the physiology of hatchling loggerhead sea turtles ( Caretta caretta ). Sample extraction and data acquisition methods for very small volume whole blood samples and sources of variation between individual hatchlings were assessed. Sixteen unclotted, whole blood samples were obtained from 7-day-old hatchlings after a 4-day cutaneous exposure to either control seawater, crude oil, Corexit 9500A or a combination of crude oil and Corexit 9500A. After extraction, one- and two-dimensional 1 H-NMR spectra of the samples were obtained, and 17 metabolites were identified and confirmed in the whole blood spectra. Variation among samples due to the concentrations of metabolites 3-hydroxybutyrate, lactate, trimethylamine oxide and propylene glycol did not statistically correlate with treatment group. However, the characterization of the hatchling loggerhead whole blood metabolome provides a foundation for future metabolomic research with sea turtles and a basis for the study of tissues from exposed hatchling sea turtles.
    Keywords: biochemistry, environmental science
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 8
    Electronic Resource
    Electronic Resource
    URBAN AGRICULTURAL ACTIVITIES AND WOMEN'S STRATEGIES IN SUSTAINING FAMILY LIVELIHOODS IN HARARE, ZIMBABWE (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Singapore journal of tropical geography 17 (1997), S. 0 
    Details
    ISSN: 1467-9493
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography
    Notes: The growing of crops on open and undeveloped spaces within urban zones in eastern and southern African cities has become an important source of food security. Urban populations have expanded without a corresponding increase in economic opportunities for employment. Economic reforms have led to the removal of subsidies on food commodities and retrenchments in the formal employment sectors. It is reported that a result of this is that vulnerable households have resorted to urban agriculture to sustain their livelihoods. Though a widespread practice, urban agriculture is not planned for or supported by urban planners and managers as a legitimate form of urban land use in Harare, Zimbabwe. As women are the main participants in urban agriculture, their activities come into direct conflict with planning provisions for urban space. This study examines the role of women in urban agriculture and views and perceptions of the use of urban space for agricultural activities in Harare. It shows that urban agriculture is useful in meeting household food needs by those who undertake it. The study offers empirical insight on the perceptions of the use of space in an urban tropical environment for agriculture, where conflicts can arise as a result of different perceptions and alternative uses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9493.1996.tb00092.x
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  • 9
    Electronic Resource
    Electronic Resource
    Intakes of beta-carotene from its use as a food additive, fortificant and dietary supplement in France, Germany and the UK (2004)
    Bradford : Emerald
    British food journal 106 (2004), S. 436-456 
    Details
    ISSN: 0007-070X
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Beta-carotene producers and food manufacturers have collated information about the usage of beta-carotene as a colourant and in fortified foods and food supplements. These data have been combined with food consumption data from some European countries consuming higher amounts of processed foods, to generate estimates of high-level intake to compare with official advice. Intake estimates of beta-carotene from food colour uses for German, French and British adults ranged from 0.4 to 1.9 mg/day. Pack dosage directions and beta-carotene content were used to estimate intakes from supplements, which could range from less than 1 mg/day to 100 mg/day. However, for the majority of products recommended daily doses were less than 10 mg/day. Theoretical intakes from fortified drinks could exceed 5 mg/day, but this level of intake is unlikely to be maintained in the longer term. The most important sources of intake appeared to be from food supplements and fortified foods. Intakes of isolated beta-carotene were comparable to intakes of natural beta-carotene from the diet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/00070700410539752
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  • 10
    Electronic Resource
    Electronic Resource
    Evaluation of Various Methods for Roasting Frozen Turkeys (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 47 (1982), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Frozen turkeys were roasted to a lower than normal final temperature (71.1°C, 160°F) by one of the following methods: (1) foil tent, 93.3°C (200°F) oven; (2) foil wrap, 93.3°C (200°F) oven; (3) foil tent, 162.8°C (325°F) oven; (4) roasting bag, 176.7°C (350°F) oven; (5) foil wrap, 204.4°C (400°F) oven; or (6) microwave oven. Birds roasted by low temperature roasting methods received highest ratings for most attributes. Basted birds were preferred for all eating quality attributes. Microwave roasted birds reached final temperature fastest and with least energy consumption, but were rated low in appearance and eating qualities, and often had undesirably pink thigh joints. Turkeys inoculated with Salmonella typhimurium and Clostridium perfringens vegetative cells were essentially sterilized by all roasting methods. These methods can be considered as convenient alternatives to conventional roasting procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1982.tb07628.x
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