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  • 1
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    The Marsili Volcanic Seamount (Southern Tyrrhenian Sea): A Potential Offshore Geothermal Resource (2015)
    Molecular Diversity Preservation International
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: Italy has a strong geothermal potential for power generation, although, at present, the only two geothermal fields being exploited are Larderello-Travale/Radicondoli and Mt. Amiata in the Tyrrhenian pre-Apennine volcanic district of Southern Tuscany. A new target for geothermal exploration and exploitation in Italy is represented by the Southern Tyrrhenian submarine volcanic district, a geologically young basin (Upper Pliocene-Pleistocene) characterised by tectonic extension where many seamounts have developed. Heat-flow data from that area show significant anomalies comparable to those of onshore geothermal fields. Fractured basaltic rocks facilitate seawater infiltration and circulation of hot water chemically altered by rock/water interactions, as shown by the widespread presence of hydrothermal deposits. The persistence of active hydrothermal activity is consistently shown by many different sources of evidence, including: heat-flow data, gravity and magnetic anomalies, widespread presence of hydrothermal-derived gases (CO2, CO, CH4), 3He/4He isotopic ratios, as well as broadband OBS/H seismological information, which demonstrates persistence of volcano-tectonic events and High Frequency Tremor (HFT). The Marsili and Tyrrhenian seamounts are thus an important—and likely long-lasting-renewable energy resource. This raises the possibility of future development of the world’s first offshore geothermal power plant.
    Beschreibung: Published
    Beschreibung: 4068-4086
    Beschreibung: 3A. Ambiente Marino
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): Marsili seamount ; hydrothermal circulation ; geothermal resource ; 04. Solid Earth::04.04. Geology::04.04.04. Marine geology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 2
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    Combined Use of Terrestrial Laser Scanning and IR Thermography Applied to a Historical Building (2015)
    MDPI
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: Abstract: The conservation of architectural heritage usually requires a multidisciplinary approach involving a variety of specialist expertise and techniques. Nevertheless, destructive techniques should be avoided, wherever possible, in order to preserve the integrity of the historical buildings, therefore the development of non-destructive and non-contact techniques is extremely important. In this framework, a methodology for combining the terrestrial laser scanning and the infrared thermal images is proposed, in order to obtain a reconnaissance of the conservation state of a historical building. The proposed case study is represented by St. Augustine Monumental Compound, located in the historical centre of the town of Cosenza (Calabria, South Italy). Adopting the proposed methodology, the paper illustrates the main results obtained for the building test overlaying and comparing the collected data with both techniques, in order to outline the capabilities both to detect the anomalies and to improve the knowledge on health state of the masonry building. The 3D model, also, allows to provide a reference model, laying the groundwork for implementation of a monitoring multisensor system based on the use of non-destructive techniques.
    Beschreibung: The presented work has been carried out in the PON Monitoraggio in Area Sismica di SIstemi MOnumentali (MASSIMO) project framework, managed by the Italian National Institute of Geophysics and Volcanology (INGV) and funded by the Italian Ministry of Education, University and Research
    Beschreibung: Published
    Beschreibung: 194-213
    Beschreibung: 6A. Monitoraggio ambientale, sicurezza e territorio
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): terrestrial laser scanner ; IR thermography ; historical buildings conservation ; preventive diagnosis ; 05. General::05.04. Instrumentation and techniques of general interest::05.04.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 3
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    Temperature-induced viral resistance in Emiliania huxleyi (Prymnesiophyceae) (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-25
    Beschreibung: © The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 9 (2014): e112134, doi:10.1371/journal.pone.0112134.
    Beschreibung: Annual Emiliania huxleyi blooms (along with other coccolithophorid species) play important roles in the global carbon and sulfur cycles. E. huxleyi blooms are routinely terminated by large, host-specific dsDNA viruses, (Emiliania huxleyi Viruses; EhVs), making these host-virus interactions a driving force behind their potential impact on global biogeochemical cycles. Given projected increases in sea surface temperature due to climate change, it is imperative to understand the effects of temperature on E. huxleyi’s susceptibility to viral infection and its production of climatically active dimethylated sulfur species (DSS). Here we demonstrate that a 3°C increase in temperature induces EhV-resistant phenotypes in three E. huxleyi strains and that successful virus infection impacts DSS pool sizes. We also examined cellular polar lipids, given their documented roles in regulating host-virus interactions in this system, and propose that alterations to membrane-bound surface receptors are responsible for the observed temperature-induced resistance. Our findings have potential implications for global biogeochemical cycles in a warming climate and for deciphering the particular mechanism(s) by which some E. huxleyi strains exhibit viral resistance.
    Beschreibung: This study was supported by funding from the National Science Foundation (OCE-1061883 to KDB, BVM, and OCE-1061876 to GRD) and in part by grants from The Gordon and Betty Moore Foundation (to BVM and KDB).
    Repository-Name: Woods Hole Open Access Server
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  • 4
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    Protist community grazing on prokaryotic prey in deep ocean water masses (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-25
    Beschreibung: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 10 (2015): e0124505, doi:10.1371/journal.pone.0124505.
    Beschreibung: Oceanic protist grazing at mesopelagic and bathypelagic depths, and their subsequent effects on trophic links between eukaryotes and prokaryotes, are not well constrained. Recent studies show evidence of higher than expected grazing activity by protists down to mesopelagic depths. This study provides the first exploration of protist grazing in the bathypelagic North Atlantic Deep Water (NADW). Grazing was measured throughout the water column at three stations in the South Atlantic using fluorescently-labeled prey analogues. Grazing in the deep Antarctic Intermediate water (AAIW) and NADW at all three stations removed 3.79% ± 1.72% to 31.14% ± 8.24% of the standing prokaryote stock. These results imply that protist grazing may be a significant source of labile organic carbon at certain meso- and bathypelagic depths.
    Beschreibung: Funding for the cruise was provided by the National Science Foundation (OCE-1154320) to EBK. Funding for the laboratory work was provided by contributions from the Woods Hole Oceanographic Institution Director of Research, Ocean Life Institute, and Deep Ocean Exploration Institute to VE.
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  • 5
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    Exploration of the canyon-incised continental margin of the northeastern United States reveals dynamic habitats and diverse communities (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-25
    Beschreibung: This is an open access article, free of all copyright. The definitive version was published in PLoS One 10 (2015): e0139904, doi: 10.1371/journal.pone.0139904.
    Beschreibung: The continental margin off the northeastern United States (NEUS) contains numerous, topographically complex features that increase habitat heterogeneity across the region. However, the majority of these rugged features have never been surveyed, particularly using direct observations. During summer 2013, 31 Remotely-Operated Vehicle (ROV) dives were conducted from 494 to 3271 m depth across a variety of seafloor features to document communities and to infer geological processes that produced such features. The ROV surveyed six broad-scale habitat features, consisting of shelf-breaching canyons, slope-sourced canyons, inter-canyon areas, open-slope/landslide-scar areas, hydrocarbon seeps, and Mytilus Seamount. Four previously unknown chemosynthetic communities dominated by Bathymodiolus mussels were documented. Seafloor methane hydrate was observed at two seep sites. Multivariate analyses indicated that depth and broad-scale habitat significantly influenced megafaunal coral (58 taxa), demersal fish (69 taxa), and decapod crustacean (34 taxa) assemblages. Species richness of fishes and crustaceans significantly declined with depth, while there was no relationship between coral richness and depth. Turnover in assemblage structure occurred on the middle to lower slope at the approximate boundaries of water masses found previously in the region. Coral species richness was also an important variable explaining variation in fish and crustacean assemblages. Coral diversity may serve as an indicator of habitat suitability and variation in available niche diversity for these taxonomic groups. Our surveys added 24 putative coral species and three fishes to the known regional fauna, including the black coral Telopathes magna, the octocoral Metallogorgia melanotrichos and the fishes Gaidropsarus argentatus, Guttigadus latifrons, and Lepidion guentheri. Marine litter was observed on 81% of the dives, with at least 12 coral colonies entangled in debris. While initial exploration revealed the NEUS region to be both geologically dynamic and biologically diverse, further research into the abiotic conditions and the biotic interactions that influence species abundance and distribution is needed.
    Beschreibung: Funding for the ship and ROV time was provided by NOAA’s Office of Ocean Exploration and Research with support from NOAA’s Deep Sea Coral Research and Technology Program, Northeast Initiative.
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  • 6
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    Microbial iron mats at the Mid-Atlantic Ridge and evidence that Zetaproteobacteria may be restricted to iron-oxidizing marine systems (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-25
    Beschreibung: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 10 (2015): e0119284, doi:10.1371/journal.pone.0119284 .
    Beschreibung: Chemolithoautotrophic iron-oxidizing bacteria play an essential role in the global iron cycle. Thus far, the majority of marine iron-oxidizing bacteria have been identified as Zetaproteobacteria, a novel class within the phylum Proteobacteria. Marine iron-oxidizing microbial communities have been found associated with volcanically active seamounts, crustal spreading centers, and coastal waters. However, little is known about the presence and diversity of iron-oxidizing communities at hydrothermal systems along the slow crustal spreading center of the Mid-Atlantic Ridge. From October to November 2012, samples were collected from rust-colored mats at three well-known hydrothermal vent systems on the Mid-Atlantic Ridge (Rainbow, Trans-Atlantic Geotraverse, and Snake Pit) using the ROV Jason II. The goal of these efforts was to determine if iron-oxidizing Zetaproteobacteria were present at sites proximal to black smoker vent fields. Small, diffuse flow venting areas with high iron(II) concentrations and rust-colored microbial mats were observed at all three sites proximal to black smoker chimneys. A novel, syringe-based precision sampler was used to collect discrete microbial iron mat samples at the three sites. The presence of Zetaproteobacteria was confirmed using a combination of 16S rRNA pyrosequencing and single-cell sorting, while light micros-copy revealed a variety of iron-oxyhydroxide structures, indicating that active iron-oxidizing communities exist along the Mid-Atlantic Ridge. Sequencing analysis suggests that these iron mats contain cosmopolitan representatives of Zetaproteobacteria, but also exhibit diversity that may be uncommon at other iron-rich marine sites studied to date. A meta-analysis of publically available data encompassing a variety of aquatic habitats indicates that Zetaproteobacteria are rare if an iron source is not readily available. This work adds to the growing understanding of Zetaproteobacteria ecology and suggests that this organism is likely locally restricted to iron-rich marine environments but may exhibit wide-scale geographic distribution, further underscoring the importance of Zetaproteobacteria in global iron cycling.
    Beschreibung: This work was supported by grants from the National Science Foundation [grants OCE-0926805 (DE and JAB), OCE-1155754 (DE), and OCE-1131109 (GWL)] and the National Aeronautics and Space Administration [NNX12AG20G (GWL and DE)].
    Repository-Name: Woods Hole Open Access Server
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  • 7
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    Microbial gene abundance and expression patterns across a river to ocean salinity gradient (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-25
    Beschreibung: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 10 (2015): e0140578, doi: 10.1371/journal.pone.0140578.
    Beschreibung: Microbial communities mediate the biogeochemical cycles that drive ecosystems, and it is important to understand how these communities are affected by changing environmental conditions, especially in complex coastal zones. As fresh and marine waters mix in estuaries and river plumes, the salinity, temperature, and nutrient gradients that are generated strongly influence bacterioplankton community structure, yet, a parallel change in functional diversity has not been described. Metagenomic and metatranscriptomic analyses were conducted on five water samples spanning the salinity gradient of the Columbia River coastal margin, including river, estuary, plume, and ocean, in August 2010. Samples were pre-filtered through 3 μm filters and collected on 0.2 μm filters, thus results were focused on changes among free-living microbial communities. Results from metagenomic 16S rRNA sequences showed taxonomically distinct bacterial communities in river, estuary, and coastal ocean. Despite the strong salinity gradient observed over sampling locations (0 to 33), the functional gene profiles in the metagenomes were very similar from river to ocean with an average similarity of 82%. The metatranscriptomes, however, had an average similarity of 31%. Although differences were few among the metagenomes, we observed a change from river to ocean in the abundance of genes encoding for catabolic pathways, osmoregulators, and metal transporters. Additionally, genes specifying both bacterial oxygenic and anoxygenic photosynthesis were abundant and expressed in the estuary and plume. Denitrification genes were found throughout the Columbia River coastal margin, and most highly expressed in the estuary. Across a river to ocean gradient, the free-living microbial community followed three different patterns of diversity: 1) the taxonomy of the community changed strongly with salinity, 2) metabolic potential was highly similar across samples, with few differences in functional gene abundance from river to ocean, and 3) gene expression was highly variable and generally was independent of changes in salinity.
    Beschreibung: This study was carried out within the context of the Science and Technology Center for Coastal Margin Observation & Prediction (CMOP) supported by the National Science Foundation, grant number OCE-0424602 to Antonio Baptista (http://www.stccmop.org).
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  • 8
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    Inbreeding ratio and genetic relationships among strains of the Western clawed frog, Xenopus tropicalis (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-25
    Beschreibung: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 10 (2015): e0133963, doi: 10.1371/journal.pone.0133963.
    Beschreibung: The Western clawed frog, Xenopus tropicalis, is a highly promising model amphibian, especially in developmental and physiological research, and as a tool for understanding disease. It was originally found in the West African rainforest belt, and was introduced to the research community in the 1990s. The major strains thus far known include the Nigerian and Ivory Coast strains. However, due to its short history as an experimental animal, the genetic relationship among the various strains has not yet been clarified, and establishment of inbred strains has not yet been achieved. Since 2003 the Institute for Amphibian Biology (IAB), Hiroshima University has maintained stocks of multiple X. tropicalis strains and conducted consecutive breeding as part of the National BioResource Project. In the present study we investigated the inbreeding ratio and genetic relationship of four inbred strains at IAB, as well as stocks from other institutions, using highly polymorphic microsatellite markers and mitochondrial haplotypes. Our results show successive reduction of heterozygosity in the genome of the IAB inbred strains. The Ivory Coast strains clearly differed from the Nigerian strains genetically, and three subgroups were identified within both the Nigerian and Ivory Coast strains. It is noteworthy that the Ivory Coast strains have an evolutionary divergent genetic background. Our results serve as a guide for the most effective use of X. tropicalis strains, and the long-term maintenance of multiple strains will contribute to further research efforts.
    Beschreibung: This work was supported by grants from the Wellcome Trust (101480/Z/13/Z, http://www.wellcome.ac.uk/stellent/group​s/corporatesite/@msh_publishing_group/do​cuments/web_document/wts058331.pdf) and Biotechnology and Biological Sciences Research Council (BB/K019988/1, http://www.bbsrc.ac.uk/pa/grants/AwardDe​tails.aspx?FundingReference=BB/K019988/1) to the European Xenopus Resource Centre. This work was also supported by a Grant-in-Aid for Young Scientists (B) (No. 23710282, http://kaken.nii.ac.jp/d/p/23710282.en.h​tml) to TI from the Ministry of Education, Culture, Sports, Science and Technology, Japan and a Grant-in-Aid for Scientific Research (B) (No. 20510216, http://kaken.nii.ac.jp/d/p/24310173.en.h​tml) to MS from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
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  • 9
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    The influence of age and gender on skin-associated microbial communities in urban and rural human populations (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-25
    Beschreibung: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One (10): e0141842, doi:10.1371/journal.pone.0141842.
    Beschreibung: Differences in the bacterial community structure associated with 7 skin sites in 71 healthy people over five days showed significant correlations with age, gender, physical skin parameters, and whether participants lived in urban or rural locations in the same city. While body site explained the majority of the variance in bacterial community structure, the composition of the skin-associated bacterial communities were predominantly influenced by whether the participants were living in an urban or rural environment, with a significantly greater relative abundance of Trabulsiella in urban populations. Adults maintained greater overall microbial diversity than adolescents or the elderly, while the intragroup variation among the elderly and rural populations was significantly greater. Skin-associated bacterial community structure and composition could predict whether a sample came from an urban or a rural resident ~5x greater than random.
    Beschreibung: This work was supported by a grant from Johnson & Johnson (China).
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  • 10
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    African baobabs with false inner cavities : the radiocarbon investigation of the Lebombo Eco Trail Baobab (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-25
    Beschreibung: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS ONE 10 (2015): e0117193, doi:10.1371/journal.pone.0117193.
    Beschreibung: The article reports the radiocarbon investigation results of the Lebombo Eco Trail tree, a representative African baobab from Mozambique. Several wood samples collected from the large inner cavity and from the outer part of the tree were investigated by AMS radiocarbon dating. According to dating results, the age values of all samples increase from the sampling point with the distance into the wood. For samples collected from the cavity walls, the increase of age values with the distance into the wood (up to a point of maximum age) represents a major anomaly. The only realistic explanation for this anomaly is that such inner cavities are, in fact, natural empty spaces between several fused stems disposed in a ring-shaped structure. We named them false cavities. Several important differences between normal cavities and false cavities are presented. Eventually, we dated other African baobabs with false inner cavities. We found that this new architecture enables baobabs to reach large sizes and old ages. The radiocarbon date of the oldest sample was 1425 ± 24 BP, which corresponds to a calibrated age of 1355 ± 15 yr. The dating results also show that the Lebombo baobab consists of five fused stems, with ages between 900 and 1400 years; these five stems build the complete ring. The ring and the false cavity closed 800–900 years ago. The results also indicate that the stems stopped growing toward the false cavity over the past 500 years.
    Beschreibung: The research was fully funded by the Romanian Ministry of National Education CNCS-UEFISCDI under grant PN-II-ID-PCE-2013-76.
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  • 11
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    An integrated assessment model for helping the United States sea scallop (Placopecten magellanicus) fishery plan ahead for ocean acidification and warming (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-25
    Beschreibung: © The Author(s), 2015. This is an open access article, free of all copyright. The definitive version was published in PLoS One 10 (2015): e0124145, doi:10.1371/journal.pone.0124145.
    Beschreibung: Ocean acidification, the progressive change in ocean chemistry caused by uptake of atmospheric CO2, is likely to affect some marine resources negatively, including shellfish. The Atlantic sea scallop (Placopecten magellanicus) supports one of the most economically important single-species commercial fisheries in the United States. Careful management appears to be the most powerful short-term factor affecting scallop populations, but in the coming decades scallops will be increasingly influenced by global environmental changes such as ocean warming and ocean acidification. In this paper, we describe an integrated assessment model (IAM) that numerically simulates oceanographic, population dynamic, and socioeconomic relationships for the U.S. commercial sea scallop fishery. Our primary goal is to enrich resource management deliberations by offering both short- and long-term insight into the system and generating detailed policy-relevant information about the relative effects of ocean acidification, temperature rise, fishing pressure, and socioeconomic factors on the fishery using a simplified model system. Starting with relationships and data used now for sea scallop fishery management, the model adds socioeconomic decision making based on static economic theory and includes ocean biogeochemical change resulting from CO2 emissions. The model skillfully reproduces scallop population dynamics, market dynamics, and seawater carbonate chemistry since 2000. It indicates sea scallop harvests could decline substantially by 2050 under RCP 8.5 CO2 emissions and current harvest rules, assuming that ocean acidification affects P. magellanicus by decreasing recruitment and slowing growth, and that ocean warming increases growth. Future work will explore different economic and management scenarios and test how potential impacts of ocean acidification on other scallop biological parameters may influence the social-ecological system. Future empirical work on the effect of ocean acidification on sea scallops is also needed.
    Beschreibung: Cooley, Rheuban, and Doney were supported by NOAA Grant NA12NOS4780145 (www.noaa.gov) and the Center for Climate and Energy Decision Making (CEDM, NSF SES-0949710) (www.nsf.gov). Luu was supported by a WHOI Summer Student Fellowship (www.whoi.edu).
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  • 12
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    Destructive changes in the neuronal structure of the FVB/N mouse retina (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-25
    Beschreibung: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 10 (2015): e0129719, doi: 10.1371/journal.pone.0129719.
    Beschreibung: We applied a series of selective antibodies for labeling the various cell types in the mammalian retina. These were used to identify the progressive loss of neurons in the FVB/N mouse, a model of early onset retinal degeneration produced by a mutation in the pde6b gene. The immunocytochemical studies, together with electroretinogram (ERG) recordings, enabled us to examine the time course of the degenerative changes that extended from the photoreceptors to the ganglion cells at the proximal end of the retina. Our study indicates that photoreceptors in FVB/N undergo a rapid degeneration within three postnatal weeks, and that there is a concomitant loss of retinal neurons in the inner nuclear layer. Although the loss of rods was detected at an earlier age during which time M- and S-opsin molecules were translocated to the cone nuclei; by 6 months all cones had also degenerated. Neuronal remodeling was also seen in the second-order neurons with horizontal cells sprouting processes proximally and dendritic retraction in rod-driven bipolar cells. Interestingly, the morphology of cone-driven bipolar cells were affected less by the disease process. The cellular structure of inner retinal neurons, i.e., ChAT amacrine cells, ganglion cells, and melanopsin-positive ganglion cells did not exhibit any gross changes of cell densities and appeared to be relatively unaffected by the massive photoreceptor degeneration in the distal retina. However, Muller cell processes began to express GFAP at their endfeet at p14, and it climbed progressively to the cell’s distal ends by 6 months. Our study indicates that FVB/N mouse provides a useful model with which to assess possible intervention strategies to arrest photoreceptor death in related diseases.
    Beschreibung: This study was supported by grants from the National Science Foundation (NSF, IOS-1021646, WS) and the National Eye Institute (NEI, EY 14161, WS).
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  • 13
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    Land subsidence, Ground Fissures and Buried Faults: InSAR Monitoring of Ciudad Guzmán (Jalisco, Mexico) (2015)
    Molecular Diversity Preservation International
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    Publikationsdatum: 2017-04-04
    Beschreibung: We study land subsidence processes and the associated ground fissuring, affecting an active graben filled by thick unconsolidated deposits by means of InSAR techniques and fieldwork. On 21 September 2012, Ciudad Guzmán (Jalisco, Mexico) was struck by ground fissures of about 1.5 km of length, causing the deformation of the roads and the propagation of fissures in adjacent buildings. The field survey showed that fissures alignment is coincident with the escarpments produced on 19 September 1985, when a strong earthquake with magnitude 8.1 struck central Mexico. In order to detect and map the spatio-temporal features of the processes that led to the 2012 ground fissures, we applied InSAR multitemporal techniques to process ENVISAT-ASAR and RADARSAT-2 satellite SAR images acquired between 2003 and 2012. We detect up to 20 mm/year of subsidence of the northwestern part of Ciudad Guzmán. These incremental movements are consistent with the ground fissures observed in 2012. Based on interferometric results, field data and 2D numerical model, we suggest that ground deformations and fissuring are due to the presence of areal subsidence correlated with variable sediment thickness and differential compaction, partly driven by the exploitation of the aquifers and controlled by the distribution and position of buried faults.
    Beschreibung: Published
    Beschreibung: 8610-8630
    Beschreibung: 6A. Monitoraggio ambientale, sicurezza e territorio
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): InSAR ; ground subsidence ; buried faults ; ground fissuring ; 04. Solid Earth::04.01. Earth Interior::04.01.02. Geological and geophysical evidences of deep processes
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 14
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    InSAR Time Series Analysis of Natural and Anthropogenic Coastal Plain Subsidence: The Case of Sibari (Southern Italy) (2015)
    Molecular Diversity Preservation International
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: We applied the Small Baseline Subset multi-temporal InSAR technique (SBAS) to two SAR datasets acquired from 2003 up to 2013 by Envisat (ESA, European Space Agency) and COSMO-SkyMed (ASI, Italian Space Agency) satellites to investigate spatial and temporal patterns of land subsidence in the Sibari Plain (Southern Italy). Subsidence processes (up to ~20 mm/yr) were investigated comparing geological, hydrogeological, and land use information with interferometric results. We suppose a correlation between subsidence and thickness of the Plio-Quaternary succession suggesting an active role of the isostatic compensation. Furthermore, the active back thrusting in the Corigliano Gulf could trigger a flexural subsidence mechanism even if fault activity and earthquakes do not seem play a role in the present subsidence. In this context, the compaction of Holocene deposits contributes to ground deformation. Despite the rapid urbanization of the area in the last 50 years, we do not consider the intensive groundwater pumping and related water table drop as the main triggering cause of subsidence phenomena, in disagreement with some previous publications. Our interpretation for the deformation fields related to natural and anthropogenic factors would be a comprehensive and exhaustive justification to the complexity of subsidence processes in the Sibari Plain.
    Beschreibung: PON (Operational National Plan) 2007–2013 from MIUR (Italian Research Ministry of Research) Project AMICUS (Study for the environmental protection and the mitigation of Anthropogenic Pollution In the Coastal Environment of selected areas of Calabria; ID: PON01_ 02818) - COSMO-SkyMed® PRODUCTS, © ASI (Italian Space Agency)—provided under license of ASI in the framework of the S3 Project “Short term earthquake prediction and preparation” (DPC-INGV, 2013). The Envisat images are provided by ESA (European Space Agency) under the CAT.1P 5605
    Beschreibung: Published
    Beschreibung: 16004–16023
    Beschreibung: 6A. Monitoraggio ambientale, sicurezza e territorio
    Beschreibung: 1IT. Reti di monitoraggio e Osservazioni
    Beschreibung: JCR Journal
    Beschreibung: restricted
    Schlagwort(e): SBAS-InSAR ; Sibari Plain ; subsidence ; geology ; anthropic processes ; 04. Solid Earth::04.03. Geodesy::04.03.07. Satellite geodesy
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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    Reef-fidelity and migration of tiger sharks, Galeocerdo cuvier, across the Coral Sea (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-26
    Beschreibung: © The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 9 (2014): e83249, doi:10.1371/journal.pone.0083249.
    Beschreibung: Knowledge of the habitat use and migration patterns of large sharks is important for assessing the effectiveness of large predator Marine Protected Areas (MPAs), vulnerability to fisheries and environmental influences, and management of shark–human interactions. Here we compare movement, reef-fidelity, and ocean migration for tiger sharks, Galeocerdo cuvier, across the Coral Sea, with an emphasis on New Caledonia. Thirty-three tiger sharks (1.54 to 3.9 m total length) were tagged with passive acoustic transmitters and their localised movements monitored on receiver arrays in New Caledonia, the Chesterfield and Lord Howe Islands in the Coral Sea, and the east coast of Queensland, Australia. Satellite tags were also used to determine habitat use and movements among habitats across the Coral Sea. Sub-adults and one male adult tiger shark displayed year-round residency in the Chesterfields with two females tagged in the Chesterfields and detected on the Great Barrier Reef, Australia, after 591 and 842 days respectively. In coastal barrier reefs, tiger sharks were transient at acoustic arrays and each individual demonstrated a unique pattern of occurrence. From 2009 to 2013, fourteen sharks with satellite and acoustic tags undertook wide-ranging movements up to 1114 km across the Coral Sea with eight detected back on acoustic arrays up to 405 days after being tagged. Tiger sharks dove 1136 m and utilised three-dimensional activity spaces averaged at 2360 km3. The Chesterfield Islands appear to be important habitat for sub-adults and adult male tiger sharks. Management strategies need to consider the wide-ranging movements of large (sub-adult and adult) male and female tiger sharks at the individual level, whereas fidelity to specific coastal reefs may be consistent across groups of individuals. Coastal barrier reef MPAs, however, only afford brief protection for large tiger sharks, therefore determining the importance of other oceanic Coral Sea reefs should be a priority for future research.
    Beschreibung: Funding was provided by the the Agence Francaise de Développement (http://www.afd.fr), French Pacific Fund, the CRISP program (www.crisponline.info) and QLD Fisheries.
    Repository-Name: Woods Hole Open Access Server
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    Chemical composition and potential environmental impacts of water-soluble polar crude oil components inferred from ESI FT-ICR MS (2015)
    Public Library of Science
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 10 (2015): e0136376, doi:10.1371/journal.pone.0136376.
    Beschreibung: Polar petroleum components enter marine environments through oil spills and natural seepages each year. Lately, they are receiving increased attention due to their potential toxicity to marine organisms and persistence in the environment. We conducted a laboratory experiment and employed state-of-the-art Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) to characterize the polar petroleum components within two operationally-defined seawater fractions: the water-soluble fraction (WSF), which includes only water-soluble molecules, and the water-accommodated fraction (WAF), which includes WSF and microscopic oil droplets. Our results show that compounds with higher heteroatom (N, S, O) to carbon ratios (NSO:C) than the parent oil were selectively partitioned into seawater in both fractions, reflecting the influence of polarity on aqueous solubility. WAF and WSF were compositionally distinct, with unique distributions of compounds across a range of hydrophobicity. These compositional differences will likely result in disparate impacts on environmental health and organismal toxicity, and thus highlight the need to distinguish between these often-interchangeable terminologies in toxicology studies. We use an empirical model to estimate hydrophobicity character for individual molecules within these complex mixtures and provide an estimate of the potential environmental impacts of different crude oil components.
    Beschreibung: This study is funded by the Gulf of Mexico Research Initiative (GOMRI) Project # 161684 to Dr. Elizabeth B. Kujawinski.
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    An unexpected diversity of photoreceptor classes in the longfin squid, Doryteuthis pealeii (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-26
    Beschreibung: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 10 (2015): e0135381, doi:10.1371/journal.pone.0135381.
    Beschreibung: Cephalopods are famous for their ability to change color and pattern rapidly for signaling and camouflage. They have keen eyes and remarkable vision, made possible by photoreceptors in their retinas. External to the eyes, photoreceptors also exist in parolfactory vesicles and some light organs, where they function using a rhodopsin protein that is identical to that expressed in the retina. Furthermore, dermal chromatophore organs contain rhodopsin and other components of phototransduction (including retinochrome, a photoisomerase first found in the retina), suggesting that they are photoreceptive. In this study, we used a modified whole-mount immunohistochemical technique to explore rhodopsin and retinochrome expression in a number of tissues and organs in the longfin squid, Doryteuthis pealeii. We found that fin central muscles, hair cells (epithelial primary sensory neurons), arm axial ganglia, and sucker peduncle nerves all express rhodopsin and retinochrome proteins. Our findings indicate that these animals possess an unexpected diversity of extraocular photoreceptors and suggest that extraocular photoreception using visual opsins and visual phototransduction machinery is far more widespread throughout cephalopod tissues than previously recognized.
    Beschreibung: This research was supported by the Office of Naval Research Basic Research Challenge grant number N00014-10-0989 to TWC and RTH and a Biotechnology and Biological Sciences Research Council (BBSRC) David Phillips Fellowship BB/L024667/1 to TJW. The authors gratefully acknowledge support from the Air Force Office of Scientific Research via grants numbered FA9550-09-0346 to RTH. and FA9550-12-1-0321 to TWC.
    Repository-Name: Woods Hole Open Access Server
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    Influence of acidic pH on hydrogen and acetate production by an electrosynthetic microbiome (2015)
    Public Library of Science
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    Publikationsdatum: 2022-05-26
    Beschreibung: © The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 9 (2014): e109935, doi:10.1371/journal.pone.0109935.
    Beschreibung: Production of hydrogen and organic compounds by an electrosynthetic microbiome using electrodes and carbon dioxide as sole electron donor and carbon source, respectively, was examined after exposure to acidic pH (~5). Hydrogen production by biocathodes poised at −600 mV vs. SHE increased〉100-fold and acetate production ceased at acidic pH, but ~5–15 mM (catholyte volume)/day acetate and〉1,000 mM/day hydrogen were attained at pH ~6.5 following repeated exposure to acidic pH. Cyclic voltammetry revealed a 250 mV decrease in hydrogen overpotential and a maximum current density of 12.2 mA/cm2 at −765 mV (0.065 mA/cm2 sterile control at −800 mV) by the Acetobacterium-dominated community. Supplying −800 mV to the microbiome after repeated exposure to acidic pH resulted in up to 2.6 kg/m3/day hydrogen (≈2.6 gallons gasoline equivalent), 0.7 kg/m3/day formate, and 3.1 kg/m3/day acetate ( = 4.7 kg CO2 captured).
    Beschreibung: This research was supported by a grant from the Department of Energy, Advanced Projects Research Agency – Energy (DE-AR0000089). CWM was supported with a Director's Postdoctoral Fellowship from Argonne National Laboratory.
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    Searching for the oldest baobab of Madagascar : radiocarbon investigation of large Adansonia rubrostipa trees (2015)
    Public Library of Science
    Details
    Publikationsdatum: 2022-05-26
    Beschreibung: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 10 (2015): e0121170, doi:10.1371/journal.pone.0121170.
    Beschreibung: We extended our research on the architecture, growth and age of trees belonging to the genus Adansonia, by starting to investigate large individuals of the most widespread Malagasy species. Our research also intends to identify the oldest baobabs of Madagascar. Here we present results of the radiocarbon investigation of the two most representative Adansonia rubrostipa (fony baobab) specimens, which are located in south-western Madagascar, in the Tsimanampetsotse National Park. We found that the fony baobab called “Grandmother” consists of 3 perfectly fused stems of different ages. The radiocarbon date of the oldest sample was found to be 1136 ± 16 BP. We estimated that the oldest part of this tree, which is mainly hollow, has an age close to 1,600 yr. This value is comparable to the age of the oldest Adansonia digitata (African baobab) specimens. By its age, the Grandmother is a major candidate for the oldest baobab of Madagascar. The second investigated specimen, called the “polygamous baobab”, consists of 6 partially fused stems of different ages. According to dating results, this fony baobab is 1,000 yr old. This research is the first investigation of the structure and age of Malagasy baobabs.
    Beschreibung: The research was fully funded by the Romanian Ministry of National Education CNCS-UEFISCDI under grant PN-II-ID-PCE-2013-76 (URL: http://uefiscdi.gov.ro/).
    Repository-Name: Woods Hole Open Access Server
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  • 20
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    Chromatography, Vol. 2, Pages 515-528: Evaluation of Carbon Nanotubes Functionalized Polydimethylsiloxane Based Coatings for In-Tube Solid Phase Microextraction Coupled to Capillary Liquid Chromatography (2015)
    MDPI
    Details
    Publikationsdatum: 2015-08-11
    Beschreibung: In the present work, the performance of carbon nanotubes (c-CNTs) functionalized polydimethylsiloxane (PDMS) based coatings as extractive phases for in-tube solid phase microextraction (IT-SPME) coupled to Capillary LC (CapLC) has been evaluated. Carboxylic-single walled carbon nanotubes (c-SWNTs) and carboxylic-multi walled carbon nanotubes (c-MWNTs) have been immobilized on the activated surface of PDMS capillary columns. The effect of different percentages of diphenyl groups in the PDMS extractive phase has also been evaluated. The extraction capability of the capillary columns has been tested for different organic pollutants, nitrogen heterocyclic compounds and polycyclic aromatic compounds (PAHs). The results indicated that the use of the c-CNTs-PDMS capillary columns improve pyriproxyfen and mainly PAH extraction. Triazines were better extracted by unmodified TRB-35 and modified c-CNTs-PDMSTRB-5. The results showed that the extraction capability of the c-CNT capillary columns depends not only on the polarity of the analytes (as it occurs with PDMS columns) but also on the interactions that the analytes can establish with the immobilized c-CNTs on the PDMS columns. The extraction efficiency has been evaluated on the basis of the preconcentration rate that can be achieved, and, in this sense, the best c-CNTs-PDMS capillary column for each group of compounds can be proposed.
    Digitale ISSN: 2227-9075
    Thema: Chemie und Pharmazie
    Publiziert von MDPI
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    Entropy, Vol. 17, Pages 5729-5751: Deformed Algebras and Generalizations of Independence on Deformed Exponential Families (2015)
    MDPI Publishing
    In: Entropy
    Details
    Publikationsdatum: 2015-08-11
    Beschreibung: A deformed exponential family is a generalization of exponential families. Since the useful classes of power law tailed distributions are described by the deformed exponential families, they are important objects in the theory of complex systems. Though the deformed exponential families are defined by deformed exponential functions, these functions do not satisfy the law of exponents in general. The deformed algebras have been introduced based on the deformed exponential functions. In this paper, after summarizing such deformed algebraic structures, it is clarified how deformed algebras work on deformed exponential families. In fact, deformed algebras cause generalization of expectations. The three kinds of expectations for random variables are introduced in this paper, and it is discussed why these generalized expectations are natural from the viewpoint of information geometry. In addition, deformed algebras cause generalization of independences. Whereas it is difficult to check the well-definedness of deformed independence in general, the κ-independence is always well-defined on κ-exponential families. This is one of advantages of κ-exponential families in complex systems. Consequently, we can well generalize the maximum likelihood method for the κ-exponential family from the viewpoint of information geometry.
    Digitale ISSN: 1099-4300
    Thema: Chemie und Pharmazie , Physik
    Publiziert von MDPI Publishing
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  • 22
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    Entropy, Vol. 17, Pages 5752-5770: Consistency of Learning Bayesian Network Structures with Continuous Variables: An Information Theoretic Approach (2015)
    MDPI Publishing
    In: Entropy
    Details
    Publikationsdatum: 2015-08-11
    Beschreibung: We consider the problem of learning a Bayesian network structure given n examples and the prior probability based on maximizing the posterior probability. We propose an algorithm that runs in O(n log n) time and that addresses continuous variables and discrete variables without assuming any class of distribution. We prove that the decision is strongly consistent, i.e., correct with probability one as n ! 1. To date, consistency has only been obtained for discrete variables for this class of problem, and many authors have attempted to prove consistency when continuous variables are present. Furthermore, we prove that the “log n” term that appears in the penalty term of the description length can be replaced by 2(1+ε) log log n to obtain strong consistency, where ε > 0 is arbitrary, which implies that the Hannan–Quinn proposition holds.
    Digitale ISSN: 1099-4300
    Thema: Chemie und Pharmazie , Physik
    Publiziert von MDPI Publishing
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  • 23
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    IJERPH, Vol. 12, Pages 9330-9341: The Willingness-to-Pay for General Practitioners in Contractual Service and Influencing Factors among Empty Nesters in Chongqing, China (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-11
    Beschreibung: Background: In 2012, a pilot health policy of contractual service relations between general practitioners and patients was implemented in China. Due to the decline in body and cognitive function, as well as the lack of family care and narrow social support networks, the demand of health services among the elderly is much higher than that among the general population. This study aims to probe into the empty nesters’ willingness-to-pay for general practitioners using a contractual service policy, investigating empty nesters’ payment levels for the service, and analyze the main factors affecting the willingness of empty-nesters’ general practitioners using contractual service supply cost. Methods: This cross-sectional study adopted a multistage stratified sampling method to survey 865, city empty nesters (six communities in three districts of one city) aged 60–85 years. A condition value method was used to infer the distribution of the willingness-to-pay; Cox’s proportional hazards regression model was used to analyze the influencing factors of willingness-to-pay. Results: More than seventy percent (76.6%) of the empty nesters in this city were willing to pay general practitioners using contract service in Chongqing. The level of willingness-to-pay for the surveyed empty nesters was 34.1 yuan per year. The median value was 22.1 yuan per year, which was below the Chongqing urban and rural cooperative medical insurance individual funding level (60 yuan per year) in 2013. Cox’s proportional hazards regression model analysis showed that the higher the education level was, the worse the self-reported health status would be, accompanied by higher family per capita income, higher satisfaction of community health service, and higher willingness-to-pay empty nesters using a contract service. Women had a higher willingness-to-pay than men. Conclusions: The willingness-to-pay for general practitioners by contractual service is high among city empty nesters in Chongqing, thus, individual financing is feasible. However, people are willing to pay less than half of the current personal financing of cooperative medical insurance of urban and rural residents. Education level, family per capita income, and self-reported health status are the main factors affecting the cost sharing intention for general practitioners using contract service supply. According to the existing situation of different empty nesters, it is important to perfect the design of general practitioners using a contractual service policy system, according to differentiated personal financing levels.
    Print ISSN: 1661-7827
    Digitale ISSN: 1660-4601
    Thema: Energietechnik , Medizin
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  • 24
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    Materials, Vol. 8, Pages 5138-5153: A Unified Model for the Prediction of Yield Strength in Particulate-Reinforced Metal Matrix Nanocomposites (2015)
    MDPI Publishing
    In: Materials
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    Publikationsdatum: 2015-08-11
    Beschreibung: Lightweighting in the transportation industry is today recognized as one of the most important strategies to improve fuel efficiency and reduce anthropogenic climate-changing, environment-damaging, and human death-causing emissions. However, the structural applications of lightweight alloys are often limited by some inherent deficiencies such as low stiffness, high wear rate and inferior strength. These properties could be effectively enhanced by the addition of stronger and stiffer reinforcements, especially nano-sized particles, into metal matrix to form composites. In most cases three common strengthening mechanisms (load-bearing effect, mismatch of coefficients of thermal expansion, and Orowan strengthening) have been considered to predict the yield strength of metal matrix nanocomposites (MMNCs). This study was aimed at developing a unified model by taking into account the matrix grain size and porosity (which is unavoidable in the materials processing such as casting and powder metallurgy) in the prediction of the yield strength of MMNCs. The Zener pinning effect of grain boundaries by the nano-sized particles has also been integrated. The model was validated using the experimental data of magnesium- and titanium-based nanocomposites containing different types of nano-sized particles (namely, Al2O3, Y2O3, and carbon nanotubes). The predicted results were observed to be in good agreement with the experimental data reported in the literature.
    Digitale ISSN: 1996-1944
    Thema: Maschinenbau
    Publiziert von MDPI Publishing
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  • 25
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    Energies, Vol. 8, Pages 8431-8446: A New Adsorbent Composite Material Based on Metal Fiber Technology and Its Application in Adsorption Heat Exchangers (2015)
    MDPI Publishing
    In: Energies
    Details
    Publikationsdatum: 2015-08-11
    Beschreibung: In order to achieve process intensification for adsorption chillers and heat pumps, a new composite material was developed based on sintered aluminum fibers from a melt-extraction process and a dense layer of silico-aluminophosphate (SAPO-34) on the fiber surfaces. The SAPO-34 layer was obtained through a partial support transformation (PST) process. Preparation of a composite sample is described and its characteristic pore size distribution and heat conductivity are presented. Water adsorption data obtained under conditions of a large pressure jump are given. In the next step, preparation of the composite was scaled up to larger samples which were fixed on a small adsorption heat exchanger. Adsorption measurements on this heat exchanger element that confirm the achieved process intensification are presented. The specific cooling power for the adsorption step per volume of composite is found to exceed 500 kW/m3 under specified conditions.
    Digitale ISSN: 1996-1073
    Thema: Energietechnik
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  • 26
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    Sensors, Vol. 15, Pages 19393-19415: Ultrasonic Technique for Density Measurement of Liquids in Extreme Conditions (2015)
    MDPI Publishing
    In: Sensors
    Details
    Publikationsdatum: 2015-08-08
    Beschreibung: An ultrasonic technique, invariant to temperature changes, for a density measurement of different liquids under in situ extreme conditions is presented. The influence of geometry and material parameters of the measurement system (transducer, waveguide, matching layer) on measurement accuracy and reliability is analyzed theoretically along with experimental results. The proposed method is based on measurement of the amplitude of the ultrasonic wave, reflected from the interface of the solid/liquid medium under investigation. In order to enhance sensitivity, the use of a quarter wavelength acoustic matching layer is proposed. Therefore, the sensitivity of the measurement system increases significantly. Density measurements quite often must be performed in extreme conditions at high temperature (up to 220 °C) and high pressure. In this case, metal waveguides between piezoelectric transducer and the measured liquid are used in order to protect the conventional transducer from the influence of high temperature and to avoid depolarization. The presented ultrasonic density measurement technique is suitable for density measurement in different materials, including liquids and polymer melts in extreme conditions. A new calibration algorithm was proposed. The metrological evaluation of the measurement method was performed. The expanded measurement uncertainty Uρ = 7.4 × 10−3 g/cm3 (1%).
    Digitale ISSN: 1424-8220
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Publiziert von MDPI Publishing
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  • 27
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    Sustainability, Vol. 7, Pages 10837-10853: Diversity and Abundance of Soil Animals as Influenced by Long-Term Fertilization in Grey Desert Soil, China (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-08
    Beschreibung: The relationship between soil fauna and different fertilizer management practices is of growing concern. The aim of this research was to investigate the response of soil fauna to fertilization regimes, to explore the relationships among the community of soil animals, soil moisture and crop yields. The application of organic fertilizers (i.e., sheep manure or crop residues) increased crop yields and promoted the number of individuals and species of soil fauna owing to the exogenous organic matter that fertilizers provided for the survival and development of soil fauna. Furthermore, the treatments that applied sheep manure (i.e., sheep manure only or nitrogen, phosphorus, potassium and sheep manure plus) were significantly beneficial for increasing crop yields and diversity of soil fauna compared to treatments with crop residues returned (i.e., crop residues returned only or nitrogen, phosphorus, potassium and crop residues returned to the field) (p 〈 0.05) due to the response of soil fauna to diverse exogenous nutrients and the effect of soil fertility. Therefore, the finding that soil fauna abundance is significantly positively correlated with soil moisture and crop yield may mean the effects of fertilizer applications on soil animals were partly masked by the soil moisture and crop yield.
    Digitale ISSN: 2071-1050
    Thema: Energietechnik
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  • 28
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    The Role of Liver in Determining Serum Colon-Derived Uremic Solutes (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-11
    Beschreibung: by Cheng-Jui Lin, Tai-Cherng Liou, Chi-Feng Pan, Pei-Chen Wu, Fang-Ju Sun, Hsuan-Liang Liu, Han-Hsiang Chen, Chih-Jen Wu Evidence has shown that indoxyl sulfate (IS) and p-cresyl sulfate (PCS) may be alternative predictors of clinical outcomes in chronic kidney disease (CKD). Both toxins are derived from the gastrointestinal tract and metabolised in the liver. However, it is unclear whether the liver affects the production of IS and PCS. Here, we explore the association between IS and PCS levels in liver cirrhosis and a CKD-based cohort (N = 115). Liver and kidney function was assessed and classified by a Child-Pugh score (child A–C) and a modified version of the Modification of Diet in Renal Disease (MDRD) equation (Stages 1–4), respectively. An animal model was also used to confirm the two toxin levels in a case of liver fibrosis. In patients with early liver cirrhosis (child A), IS and PCS were significantly associated with CKD stages. In contrast, serum IS and PCS did not significantly change in advanced liver cirrhosis (child C). A stepwise multiple linear regression analysis also showed that T-PCS was significantly associated with stages of liver cirrhosis after adjusting for other confounding factors (B = -2.29, p = 0.012). Moreover, the serum and urine levels of T-PCS and T-IS were significantly lower in rats with liver failure than in those without ( p
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    MicroRNA and Transcription Factor Mediated Regulatory Network Analysis Reveals Critical Regulators and Regulatory Modules in Myocardial Infarction (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
    Details
    Publikationsdatum: 2015-08-11
    Beschreibung: by Guangde Zhang, Hongbo Shi, Lin Wang, Meng Zhou, Zhenzhen Wang, Xiaoxia Liu, Liang Cheng, Weimin Li, Xueqi Li Myocardial infarction (MI) is a severe coronary artery disease and a leading cause of mortality and morbidity worldwide. However, the molecular mechanisms of MI have yet to be fully elucidated. In this study, we compiled MI-related genes, MI-related microRNAs (miRNAs) and known human transcription factors (TFs), and we then identified 1,232 feed-forward loops (FFLs) among these miRNAs, TFs and their co-regulated target genes through integrating target prediction. By merging these FFLs, the first miRNA and TF mediated regulatory network for MI was constructed, from which four regulators (SP1, ESR1, miR-21-5p and miR-155-5p) and three regulatory modules that might play crucial roles in MI were then identified. Furthermore, based on the miRNA and TF mediated regulatory network and literature survey, we proposed a pathway model for miR-21-5p, the miR-29 family and SP1 to demonstrate their potential co-regulatory mechanisms in cardiac fibrosis, apoptosis and angiogenesis. The majority of the regulatory relations in the model were confirmed by previous studies, which demonstrated the reliability and validity of this miRNA and TF mediated regulatory network. Our study will aid in deciphering the complex regulatory mechanisms involved in MI and provide putative therapeutic targets for MI.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    CD73 Activity is Dispensable for the Polarization of M2 Macrophages (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-11
    Beschreibung: by Dominik Eichin, Juha P. Laurila, Sirpa Jalkanen, Marko Salmi The ectoenzyme CD73 catalyzes the hydrolysis of AMP, and is one of the most important producers of extracellular adenosine. On regulatory T cells, CD73 is necessary for immunosuppressive functions, and on Th17 cells CD73-generated adenosine exerts anti-inflammatory effects. However, the expression and function of CD73 in pro-inflammatory M1 and in immunosuppressive M2 macrophages is largely unknown. Here we show that CD73 expression and enzyme activity were induced in in vitro polarized pro-inflammatory human M(LPS+TNF) monocytes/macrophages, while CD73 was absent from immunosuppressive M(IL-4+M-CSF)-polarized macrophages. Inhibition of CD73 activity with the inhibitor AMPCP did not affect the polarization of human monocytes. In mice, CD73 was present on resident peritoneal macrophages. In striking contrast, elicited peritoneal macrophages remained CD73 negative regardless of their polarization towards either a pro-inflammatory M(LPS) or anti-inflammatory M(IL-4c) direction. Finally, the ability of peritoneal macrophages to polarize to pro- and anti-inflammatory cells was perfectly normal in CD73-deficient mice in vivo . These data indicate that, in contrast to other major leukocyte subpopulations, CD73 activity on macrophages does not play a major role in their polarization and that in mice host CD73 on any cell type is not required in vivo for peritoneal macrophage polarization towards either a pro- or an anti-inflammatory direction.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    DNA Tetrominoes: The Construction of DNA Nanostructures Using Self-Organised Heterogeneous Deoxyribonucleic Acids Shapes (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-11
    Beschreibung: by Hui San Ong, Mohd Syafiq Rahim, Mohd Firdaus-Raih, Effirul Ikhwan Ramlan The unique programmability of nucleic acids offers alternative in constructing excitable and functional nanostructures. This work introduces an autonomous protocol to construct DNA Tetris shapes (L-Shape, B-Shape, T-Shape and I-Shape) using modular DNA blocks. The protocol exploits the rich number of sequence combinations available from the nucleic acid alphabets, thus allowing for diversity to be applied in designing various DNA nanostructures. Instead of a deterministic set of sequences corresponding to a particular design, the protocol promotes a large pool of DNA shapes that can assemble to conform to any desired structures. By utilising evolutionary programming in the design stage, DNA blocks are subjected to processes such as sequence insertion, deletion and base shifting in order to enrich the diversity of the resulting shapes based on a set of cascading filters. The optimisation algorithm allows mutation to be exerted indefinitely on the candidate sequences until these sequences complied with all the four fitness criteria. Generated candidates from the protocol are in agreement with the filter cascades and thermodynamic simulation. Further validation using gel electrophoresis indicated the formation of the designed shapes. Thus, supporting the plausibility of constructing DNA nanostructures in a more hierarchical, modular, and interchangeable manner.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    The Influence of Diabetic Peripheral Neuropathy on Local Postural Muscle and Central Sensory Feedback Balance Control (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-11
    Beschreibung: by Nima Toosizadeh, Jane Mohler, David G. Armstrong, Talal K. Talal, Bijan Najafi Poor balance control and increased fall risk have been reported in people with diabetic peripheral neuropathy (DPN). Traditional body sway measures are unable to describe underlying postural control mechanism. In the current study, we used stabilogram diffusion analysis to examine the mechanism under which balance is altered in DPN patients under local-control (postural muscle control) and central-control (postural control using sensory cueing). DPN patients and healthy age-matched adults over 55 years performed two 15-second Romberg balance trials. Center of gravity sway was measured using a motion tracker system based on wearable inertial sensors, and used to derive body sway and local/central control balance parameters. Eighteen DPN patients (age = 65.4±7.6 years; BMI = 29.3±5.3 kg/m 2 ) and 18 age-matched healthy controls (age = 69.8±2.9; BMI = 27.0±4.1 kg/m 2 ) with no major mobility disorder were recruited. The rate of sway within local-control was significantly higher in the DPN group by 49% (healthy local-control slope = 1.23±1.06×10 -2 cm 2 /sec, P
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Collective Attention and Stock Prices: Evidence from Google Trends Data on Standard and Poor's 100 (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-11
    Beschreibung: by Raphael H. Heiberger Today´s connected world allows people to gather information in shorter intervals than ever before, widely monitored by massive online data sources. As a dramatic economic event, recent financial crisis increased public interest for large companies considerably. In this paper, we exploit this change in information gathering behavior by utilizing Google query volumes as a "bad news" indicator for each corporation listed in the Standard and Poor´s 100 index. Our results provide not only an investment strategy that gains particularly in times of financial turmoil and extensive losses by other market participants, but reveal new sectoral patterns between mass online behavior and (bearish) stock market movements. Based on collective attention shifts in search queries for individual companies, hence, these findings can help to identify early warning signs of financial systemic risk. However, our disaggregated data also illustrate the need for further efforts to understand the influence of collective attention shifts on financial behavior in times of regular market activities with less tremendous changes in search volumes.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Targeted Intracellular Delivery of Resveratrol to Glioblastoma Cells Using Apolipoprotein E-Containing Reconstituted HDL as a Nanovehicle (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-11
    Beschreibung: by Sea H. Kim, Birendra Babu Adhikari, Siobanth Cruz, Michael P. Schramm, Joe A. Vinson, Vasanthy Narayanaswami The objective of this study is to transport and deliver resveratrol to intracellular sites using apolipoprotein E3 (apoE3). Reconstituted high-density lipoprotein (rHDL) bearing resveratrol (rHDL/res) was prepared using phospholipids and the low-density lipoprotein receptor (LDLr)-binding domain of apoE3. Biophysical characterization revealed that resveratrol was partitioned into the phospholipid bilayer of discoidal rHDL/res particles (~19 nm diameter). Co-immunoprecipitation studies indicated that the LDLr-binding ability of apoE3 was retained. Cellular uptake of resveratrol to intracellular sites was evaluated in glioblastoma A-172 cells by direct fluorescence using chemically synthesized NBD-labeled resveratrol (res/NBD) embedded in rHDL/res. Competition and inhibition studies indicate that the uptake is by receptor mediated endocytosis via the LDLr, with co-localization of apoE3 and res/NBD in late endosomes/lysosomes. We propose that rHDL provides an ideal hydrophobic milieu to sequester resveratrol and that rHDL containing apoE3 serves as an effective “nanovehicle” to transport and deliver resveratrol to targeted intracellular sites.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Remote Sensing, Vol. 7, Pages 10143-10163: Mapping US Urban Extents from MODIS Data Using One-Class Classification Method (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-11
    Beschreibung: Urban areas are one of the most important components of human society. Their extents have been continuously growing during the last few decades. Accurate and timely measurements of the extents of urban areas can help in analyzing population densities and urban sprawls and in studying environmental issues related to urbanization. Urban extents detected from remotely sensed data are usually a by-product of land use classification results, and their interpretation requires a full understanding of land cover types. In this study, for the first time, we mapped urban extents in the continental United States using a novel one-class classification method, i.e., positive and unlabeled learning (PUL), with multi-temporal Moderate Resolution Imaging Spectroradiometer (MODIS) data for the year 2010. The Defense Meteorological Satellite Program Operational Linescan System (DMSP-OLS) night stable light data were used to calibrate the urban extents obtained from the one-class classification scheme. Our results demonstrated the effectiveness of the use of the PUL algorithm in mapping large-scale urban areas from coarse remote-sensing images, for the first time. The total accuracy of mapped urban areas was 92.9% and the kappa coefficient was 0.85. The use of DMSP-OLS night stable light data can significantly reduce false detection rates from bare land and cropland far from cities. Compared with traditional supervised classification methods, the one-class classification scheme can greatly reduce the effort involved in collecting training datasets, without losing predictive accuracy.
    Digitale ISSN: 2072-4292
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie
    Publiziert von MDPI Publishing
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    Combined Oral Administration of Bovine Collagen Peptides with Calcium Citrate Inhibits Bone Loss in Ovariectomized Rats (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-11
    Beschreibung: by JunLi Liu, YiHu Wang, ShuJun Song, XiJie Wang, YaYa Qin, ShaoYan Si, YanChuan Guo Purpose Collagen peptides (CPs) and calcium citrate are commonly used as bone health supplements for treating osteoporosis. However, it remains unknown whether the combination of oral bovine CPs with calcium citrate is more effective than administration of either agent alone. Methods Forty 12-week-old Sprague-Dawley rats were randomly divided into five groups ( n = 8) for once-daily intragastric administration of different treatments for 3 months at 3 months after ovariectomy (OVX) as follows: sham + vehicle; OVX + vehicle; OVX + 750 mg/kg CP; OVX + CP-calcium citrate (75 mg/kg); OVX + calcium citrate (75 mg/kg). After euthanasia, the femurs were removed and analyzed by dual energy X-ray absorptiometry and micro-computed tomography, and serum samples were analyzed for bone metabolic markers. Results OVX rats supplemented with CPs or CP-calcium citrate showed osteoprotective effects, with reductions in the OVX-induced decreases in their femoral bone mineral density. Moreover, CP-calcium citrate prevented trabecular bone loss, improved the microarchitecture of the distal femur, and significantly inhibited bone loss with increased bone volume, connectivity density, and trabecular number compared with OVX control rats. CP or CP-calcium citrate administration significantly increased serum procollagen type I N-terminal propeptide levels and reduced serum bone-specific alkaline phosphatase, osteocalcin, and C-telopeptide of type I collagen levels. Conclusions Our data indicate that combined oral administration of bovine CPs with calcium citrate inhibits bone loss in OVX rats. The present findings suggest that combined oral administration of bovine CPs with calcium citrate is a promising alternative for reducing bone loss in osteopenic postmenopausal women.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Remote Sensing, Vol. 7, Pages 10164-10183: Effects of Precipitation Intensity and Temperature on NDVI-Based Grass Change over Northern China during the Period from 1982 to 2011 (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-11
    Beschreibung: The knowledge about impacts of changes in precipitation regimes on terrestrial ecosystems is fundamental to improve our understanding of global environment change, particularly in the context that heavy precipitation is expected to increase according to the 5th Intergovernmental Panel on Climate Change (IPCC) assessment. Based on observed climate data and the Advanced Very High Resolution Radiometer (AVHRR) Global Inventory Modeling and Mapping Studies (GIMMS) satellite-derived normalized difference vegetation index (NDVI), here we analyzed the spatio-temporal changes in grassland NDVI, covering 1.64 × 106 km2, in northern China and their linkages to changes in precipitation and temperature during the period 1982–2011. We found that mean growing season (April–October) grass NDVI is more sensitive to heavy precipitation than to moderate or light precipitation in both relatively arid areas (RAA) and relatively humid areas (RHA), whereas the sensitivities of grass NDVI to temperature are comparable to total precipitation in RHA. Heavy precipitation showed the strongest impacts in more than half of northern China (56%), whereas impacts of light precipitation on grass NDVI were stronger in some areas (21%), mainly distributed in northwestern China, a typical arid and semi-arid area. Our findings suggest that responses of grasslands are divergent with respect to changes in precipitation intensities.
    Digitale ISSN: 2072-4292
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie
    Publiziert von MDPI Publishing
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    IJGI, Vol. 4, Pages 1346-1365: Q-SOS—A Sensor Observation Service for Accessing Quality Descriptions of Environmental Data (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-11
    Beschreibung: The worldwide Sensor Web comprises observation data from diverse sources. Each data provider may process and assess datasets differently before making them available online. This information is often invisible to end users. Therefore, publishing observation data with quality descriptions is vital as it helps users to assess the suitability of data for their applications. It is also important to capture contextual information concerning data quality such as provenance to trace back incorrect data to its origins. In the Open Geospatial Consortium (OGC)’s Sensor Web Enablement (SWE) framework, there is no sufficiently and practically applicable approach how these aspects can be systematically represented and made accessible. This paper presents Q-SOS—an extension of the OGC’s Sensor Observation Service (SOS) that supports retrieval of observation data together with quality descriptions. These descriptions are represented in an observation data model covering various aspects of data quality assessment. The service and the data model have been developed based on open standards and open source tools, and are productively being used to share observation data from the TERENO observatory infrastructure. We discuss the advantages of deploying the presented solutions from data provider and consumer viewpoints. Enhancements applied to the related open-source developments are also introduced.
    Digitale ISSN: 2220-9964
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geologie und Paläontologie
    Publiziert von MDPI Publishing im Namen von International Society for Photogrammetry and Remote Sensing (ISPRS).
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    Sensors, Vol. 15, Pages 19507-19540: A Scalable Context-Aware Objective Function (SCAOF) of Routing Protocol for Agricultural Low-Power and Lossy Networks (RPAL) (2015)
    MDPI Publishing
    In: Sensors
    Details
    Publikationsdatum: 2015-08-11
    Beschreibung: In recent years, IoT (Internet of Things) technologies have seen great advances, particularly, the IPv6 Routing Protocol for Low-power and Lossy Networks (RPL), which provides a powerful and flexible routing framework that can be applied in a variety of application scenarios. In this context, as an important role of IoT, Wireless Sensor Networks (WSNs) can utilize RPL to design efficient routing protocols for a specific application to increase the ubiquity of networks with resource-constrained WSN nodes that are low-cost and easy to deploy. In this article, our work starts with the description of Agricultural Low-power and Lossy Networks (A-LLNs) complying with the LLN framework, and to clarify the requirements of this application-oriented routing solution. After a brief review of existing optimization techniques for RPL, our contribution is dedicated to a Scalable Context-Aware Objective Function (SCAOF) that can adapt RPL to the environmental monitoring of A-LLNs, through combining energy-aware, reliability-aware, robustness-aware and resource-aware contexts according to the composite routing metrics approach. The correct behavior of this enhanced RPL version (RPAL) was verified by performance evaluations on both simulation and field tests. The obtained experimental results confirm that SCAOF can deliver the desired advantages on network lifetime extension, and high reliability and efficiency in different simulation scenarios and hardware testbeds.
    Digitale ISSN: 1424-8220
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Publiziert von MDPI Publishing
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    Sensors, Vol. 15, Pages 19583-19596: Multi-Sensor Approach for the Monitoring of Halitosis Treatment via Lactobacillus brevis (CD2)—Containing Lozenges—A Randomized, Double-Blind Placebo-Controlled Clinical Trial (2015)
    MDPI Publishing
    In: Sensors
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    Publikationsdatum: 2015-08-11
    Beschreibung: The aim of this randomized clinical trial was to evaluate whether a recently described multi-sensor approach called BIONOTE® is accurate enough to verify the efficacy of treatment of patients with halitosis. A treatment with Lactobacillus brevis (CD2)–containing lozenges, compared with placebo was tested. The BIONOTE® was compared with traditional techniques used to detect halitosis: OralChroma™ and two calibrated odor judges enrolled for the organoleptic assessments. Twenty patients (10 treated and 10 placebo), suffering from active phase halitosis were included in the study. Treatment consisted of Lactobacillus brevis (CD2)—containing lozenges or placebo, 4 tablets/day for 14 days. t0 was before the beginning of the study; t1 was day 7 and t2 was day 14. The effectiveness of treatment was assessed through: (1) Rosenberg score; (2) Winkel tongue coating index (WTCI) anterior and posterior; (2) OralChroma™; (3) the new developed multi-sensor approach, called BIONOTE® (test technique). Only the WTCI anterior revealed statistically significant changes between t0 and t2 data (p = 0.014) in the treated group. Except for the WTCI anterior, all diagnostic methods revealed the lack of effectiveness for halitosis of a 14-days treatment with Lactobacillus brevis (CD2)–containing lozenges. The BIONOTE® multisensor system seems accurate in addition to OralChroma™ to assess the initial condition of halitosis and its mitigation during treatment.
    Digitale ISSN: 1424-8220
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Publiziert von MDPI Publishing
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    Algorithms, Vol. 8, Pages 621-631: One-Bit Quantization and Distributed Detection with an Unknown Scale Parameter (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-12
    Beschreibung: We examine a distributed detection problem in a wireless sensor network, where sensor nodes collaborate to detect a Gaussian signal with an unknown change of power, i.e., a scale parameter. Due to power/bandwidth constraints, we consider the case where each sensor quantizes its observation into a binary digit. The binary data are then transmitted through error-prone wireless links to a fusion center, where a generalized likelihood ratio test (GLRT) detector is employed to perform a global decision. We study the design of a binary quantizer based on an asymptotic analysis of the GLRT. Interestingly, the quantization threshold of the quantizer is independent of the unknown scale parameter. Numerical results are included to illustrate the performance of the proposed quantizer and GLRT in binary symmetric channels (BSCs).
    Digitale ISSN: 1999-4893
    Thema: Informatik
    Publiziert von MDPI Publishing
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    Sensors, Vol. 15, Pages 19495-19506: Distributed Wireless Monitoring System for Ullage and Temperature in Wine Barrels (2015)
    MDPI Publishing
    In: Sensors
    Details
    Publikationsdatum: 2015-08-11
    Beschreibung: This paper presents a multipurpose and low cost sensor for the simultaneous monitoring of temperature and ullage of wine in barrels in two of the most important stages of winemaking, that being fermentation and maturation. The distributed sensor subsystem is imbedded within the bung of the barrel and runs on battery for a period of at least 12 months and costs around $27 AUD for all parts. In addition, software was designed which allows for the remote transmission and easy visual interpretation of the data for the winemaker. Early warning signals can be sent when the temperature or ullage deviates from a winemakers expectations so remedial action can be taken, such as when topping is required or the movement of the barrels to a cooler cellar location. Such knowledge of a wine’s properties or storage conditions allows for a more precise control of the final wine quality.
    Digitale ISSN: 1424-8220
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Publiziert von MDPI Publishing
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  • 43
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    Materials, Vol. 8, Pages 5154-5193: Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds (2015)
    MDPI Publishing
    In: Materials
    Details
    Publikationsdatum: 2015-08-12
    Beschreibung: A fast and effective wound healing process would substantially decrease medical costs, wound care supplies, and hospitalization significantly improving the patients’ quality of life. The search for effective therapeutic approaches seems to be imperative in order to avoid the aggravation of chronic wounds. In spite of all the efforts that have been made during the recent years towards the development of artificial wound dressings, none of the currently available options combine all the requirements necessary for quick and optimal cutaneous regeneration. Therefore, technological advances in the area of temporary and permanent smart dressings for wound care are required. The development of nanoscience and nanotechnology can improve the materials and designs used in topical wound care in order to efficiently release antimicrobial, anti-inflammatory and regenerative compounds speeding up the endogenous healing process. Nanostructured dressings can overcome the limitations of the current coverings and, separately, natural origin components can also overcome the drawbacks of current antibiotics and antiseptics (mainly cytotoxicity, antibiotic resistance, and allergies). The combination of natural origin components with demonstrated antibiotic, regenerative, or anti-inflammatory properties together with nanostructured materials is a promising approach to fulfil all the requirements needed for the next generation of bioactive wound dressings. Microbially compromised wounds have been treated with different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring antimicrobial, anti-inflammatory, and regenerative components but the available evidence is limited and insufficient to be able to draw reliable conclusions and to extrapolate those findings to the clinical practice. The evidence and some promising preliminary results indicate that future comparative studies are justified but instead of talking about the beneficial or inert effects of those natural origin occurring materials, the scientific community leads towards the identification of the main active components involved and their mechanism of action during the corresponding healing, antimicrobial, or regenerative processes and in carrying out systematic and comparative controlled tests. Once those natural origin components have been identified and their efficacy validated through solid clinical trials, their combination within nanostructured dressings can open up new avenues in the fabrication of bioactive dressings with outstanding characteristics for wound care. The motivation of this work is to analyze the state of the art in the use of different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring materials as antimicrobial, anti-inflammatory and regenerative components with the aim of clarifying their potential clinical use in bioactive dressings. We conclude that, for those natural occurring materials, more clinical trials are needed to reach a sufficient level of evidence as therapeutic agents for wound healing management.
    Digitale ISSN: 1996-1944
    Thema: Maschinenbau
    Publiziert von MDPI Publishing
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  • 44
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    Viewing Complex, Dynamic Scenes “Through the Eyes” of Another Person: The Gaze-Replay Paradigm (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-09
    Beschreibung: by Jennifer Choe Bush, Peter Christopher Pantelis, Xavier Morin Duchesne, Sebastian Alexander Kagemann, Daniel Patrick Kennedy We present a novel “Gaze-Replay” paradigm that allows the experimenter to directly test how particular patterns of visual input—generated from people’s actual gaze patterns—influence the interpretation of the visual scene. Although this paradigm can potentially be applied across domains, here we applied it specifically to social comprehension. Participants viewed complex, dynamic scenes through a small window displaying only the foveal gaze pattern of a gaze “donor.” This was intended to simulate the donor’s visual selection, such that a participant could effectively view scenes “through the eyes” of another person. Throughout the presentation of scenes presented in this manner, participants completed a social comprehension task, assessing their abilities to recognize complex emotions. The primary aim of the study was to assess the viability of this novel approach by examining whether these Gaze-Replay windowed stimuli contain sufficient and meaningful social information for the viewer to complete this social perceptual and cognitive task. The results of the study suggested this to be the case; participants performed better in the Gaze-Replay condition compared to a temporally disrupted control condition, and compared to when they were provided with no visual input. This approach has great future potential for the exploration of experimental questions aiming to unpack the relationship between visual selection, perception, and cognition.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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  • 45
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    Oral Migalastat HCl Leads to Greater Systemic Exposure and Tissue Levels of Active α-Galactosidase A in Fabry Patients when Co-Administered with Infused Agalsidase (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
    Details
    Publikationsdatum: 2015-08-09
    Beschreibung: by David G. Warnock, Daniel G. Bichet, Myrl Holida, Ozlem Goker-Alpan, Kathy Nicholls, Mark Thomas, Francois Eyskens, Suma Shankar, Mathews Adera, Sheela Sitaraman, Richie Khanna, John J. Flanagan, Brandon A. Wustman, Jay Barth, Carrolee Barlow, Kenneth J. Valenzano, David J. Lockhart, Pol Boudes, Franklin K. Johnson Trial Registration ClinicalTrials.gov NCT01196871
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    LTBP-2 Has a Single High-Affinity Binding Site for FGF-2 and Blocks FGF-2-Induced Cell Proliferation (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-12
    Beschreibung: by Clementine Menz, Mahroo K. Parsi, Julian R. J. Adams, Mohamed A. Sideek, Zlatko Kopecki, Allison J. Cowin, Mark A. Gibson Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) belongs to the fibrillin-LTBP superfamily of extracellular matrix proteins. LTBPs and fibrillins are involved in the sequestration and storage of latent growth factors, particularly transforming growth factor β (TGF-β), in tissues. Unlike other LTBPs, LTBP-2 does not covalently bind TGF-β, and its molecular functions remain unclear. We are screening LTBP-2 for binding to other growth factors and have found very strong saturable binding to fibroblast growth factor-2 (FGF-2) (Kd = 1.1 nM). Using a series of recombinant LTBP-2 fragments a single binding site for FGF-2 was identified in a central region of LTBP-2 consisting of six tandem epidermal growth factor-like (EGF-like) motifs (EGFs 9–14). This region was also shown to contain a heparin/heparan sulphate-binding site. FGF-2 stimulation of fibroblast proliferation was completely negated by the addition of 5-fold molar excess of LTBP-2 to the assay. Confocal microscopy showed strong co-localisation of LTBP-2 and FGF-2 in fibrotic keloid tissue suggesting that the two proteins may interact in vivo. Overall the study indicates that LTBP-2 is a potent inhibitor of FGF-2 that may influence FGF-2 bioactivity during wound repair particularly in fibrotic tissues.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Promoter Hypomethylation of Maspin Inhibits Migration and Invasion of Extravillous Trophoblast Cells during Placentation (2015)
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    In: PLoS ONE
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    Publikationsdatum: 2015-08-12
    Beschreibung: by Xinwei Shi, Hao Liu, Jing Cao, Qing Liu, Guiju Tang, Wanlu Liu, Haiyi Liu, Dongrui Deng, Fuyuan Qiao, Yuanyuan Wu Objective Extravillous trophoblast (EVT) cells invade the endometrium and the maternal spiral arterioles during the first trimester. Mammary Serine Protease Inhibitor (Maspin, SERPINB5) plays a putative role in regulating the invasive activity of cytotrophoblasts. The maspin gene is silenced in various cancers by an epigenetic mechanism that involves aberrant cytosine methylation. We investigated the effect of the methylation status of the maspin promoter on the maspin expression and the aggressiveness of EVT cells. Methods Western blotting was used to detect the maspin protein expression in EVT cells upon hypoxia. The proliferative ability, the apoptosis rate and the migration and invasiveness were measured with Cell Counting Kit-8 assay, Flow Cytometry technology and Transwell methods. Subsequently, we treated cells with recombinant maspin protein. The methylation degree of maspin promoter region upon hypoxia/ decitabine was detected by bisulfite sequencing PCR and methylation-specific PCR. Finally, we explored the effects of decitabine on maspin protein expression and the aggressiveness of EVT cells. Results Hypoxia effectively increased maspin protein expression in EVT cells and significantly inhibited their aggressiveness. The addition of recombinant maspin protein inhibited this aggressiveness. Decitabine reduced the methylation in the maspin promoter region and effectively increased the maspin protein expression, which significantly weakened the migration and invasiveness of EVT cells. Discussion The methylation status of the maspin promoter is an important factor that affects the migration and invasion of EVT cells during early pregnancy. A decrease in the methylation status can inhibit the migration and invasion of EVT cells to affect placentation and can result in the ischemia and hypoxia of placenta.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation (2015)
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    In: PLoS ONE
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    Publikationsdatum: 2015-08-12
    Beschreibung: by Jun-Ha Hwang, Mi Ran Byun, A. Rum Kim, Kyung Min Kim, Hang Jun Cho, Yo Han Lee, Juwon Kim, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong Mesenchymal stem cell (MSC) differentiation is regulated by the extracellular matrix (ECM) through activation of intracellular signaling mediators. The stiffness of the ECM was shown to be an important regulatory factor for MSC differentiation, and transcriptional coactivator with PDZ-binding motif (TAZ) was identified as an effector protein for MSC differentiation. However, the detailed underlying mechanism regarding the role of ECM stiffness and TAZ in MSC differentiation is not yet fully understood. In this report, we showed that ECM stiffness regulates MSC fate through ERK or JNK activation. Specifically, a stiff hydrogel matrix stimulates osteogenic differentiation concomitant with increased nuclear localization of TAZ, but inhibits adipogenic differentiation. ERK and JNK activity was significantly increased in cells cultured on a stiff hydrogel. TAZ activation was induced by ERK or JNK activation on a stiff hydrogel because exposure to an ERK or JNK inhibitor significantly decreased the nuclear localization of TAZ, indicating that ECM stiffness-induced ERK or JNK activation is important for TAZ-driven osteogenic differentiation. Taken together, these results suggest that ECM stiffness regulates MSC differentiation through ERK or JNK activation.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    120 Years of U.S. Residential Housing Stock and Floor Space (2015)
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    In: PLoS ONE
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    Publikationsdatum: 2015-08-12
    Beschreibung: by Maria Cecilia P. Moura, Steven J. Smith, David B. Belzer Residential buildings are a key driver of energy consumption and also impact transportation and land-use. Energy consumption in the residential sector accounts for one-fifth of total U.S. energy consumption and energy-related CO 2 emissions, with floor space a major driver of building energy demands. In this work a consistent, vintage-disaggregated, annual long-term series of U.S. housing stock and residential floor space for 1891–2010 is presented. An attempt was made to minimize the effects of the incompleteness and inconsistencies present in the national housing survey data. Over the 1891–2010 period, floor space increased almost tenfold, from approximately 24,700 to 235,150 million square feet, corresponding to a doubling of floor space per capita from approximately 400 to 800 square feet. While population increased five times over the period, a 50% decrease in household size contributed towards a tenfold increase in the number of housing units and floor space, while average floor space per unit remains surprisingly constant, as a result of housing retirement dynamics. In the last 30 years, however, these trends appear to be changing, as household size shows signs of leveling off, or even increasing again, while average floor space per unit has been increasing. GDP and total floor space show a remarkably constant growth trend over the period and total residential sector primary energy consumption and floor space show a similar growth trend over the last 60 years, decoupling only within the last decade.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Efficient Generation of Plasmacytoid Dendritic Cell from Common Lymphoid Progenitors by Flt3 Ligand (2015)
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    In: PLoS ONE
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    Publikationsdatum: 2015-08-12
    Beschreibung: by Yi-Ling Chen, Shiun Chang, Ting-Ting Chen, Chien-Kuo Lee Dendritic cells (DCs), including conventional DCs (cDCs) and plasmacytoid DCs (pDCs) are critical for initiating and controlling the immune response. However, study of DC, particularly pDC, function is hampered by their low frequency in lymphoid organs, and existing methods for in vitro DC generation preferentially favor the production of cDCs over pDCs. Here, we demonstrated that pDCs could be efficiently generated in vitro from common lymphoid progenitors (CLPs) using Flt3 ligand (FL) in three different culture systems, namely feeder-free, BM-feeder and AC-6-feeder. This was in stark contrast to common DC progenitors (CDPs), in which cDCs were prominently generated under the same conditions. Moreover, the efficiency and function of pDCs generated from these three systems varied. While AC-6 system showed the greatest ability to support pDC development from CLPs, BM-feeder system was able to develop pDCs with better functionality. pDCs could also be expanded in vivo using hydrodynamic gene transfer of FL, which was further enhanced by the combined treatment of FL and IFN-α. Interestingly, IFN-α selectively promoted the proliferation of CLPs and not CDPs, which might contribute to enhanced pDC development. Together, we have defined conditions for in vitro and in vivo generation of pDCs, which may be useful for investigating the biology of pDCs.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    A Haptic Feedback Scheme to Accurately Position a Virtual Wrist Prosthesis Using a Three-Node Tactor Array (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-12
    Beschreibung: by Andrew Erwin, Frank C. Sup In this paper, a novel haptic feedback scheme, used for accurately positioning a 1DOF virtual wrist prosthesis through sensory substitution, is presented. The scheme employs a three-node tactor array and discretely and selectively modulates the stimulation frequency of each tactor to relay 11 discrete haptic stimuli to the user. Able-bodied participants were able to move the virtual wrist prosthesis via a surface electromyography based controller. The participants evaluated the feedback scheme without visual or audio feedback and relied solely on the haptic feedback alone to correctly position the hand. The scheme was evaluated through both normal (perpendicular) and shear (lateral) stimulations applied on the forearm. Normal stimulations were applied through a prototype device previously developed by the authors while shear stimulations were generated using an ubiquitous coin motor vibrotactor. Trials with no feedback served as a baseline to compare results within the study and to the literature. The results indicated that using normal and shear stimulations resulted in accurately positioning the virtual wrist, but were not significantly different. Using haptic feedback was substantially better than no feedback. The results found in this study are significant since the feedback scheme allows for using relatively few tactors to relay rich haptic information to the user and can be learned easily despite a relatively short amount of training. Additionally, the results are important for the haptic community since they contradict the common conception in the literature that normal stimulation is inferior to shear. From an ergonomic perspective normal stimulation has the potential to benefit upper limb amputees since it can operate at lower frequencies than shear-based vibrotactors while also generating less noise. Through further tuning of the novel haptic feedback scheme and normal stimulation device, a compact and comfortable sensory substitution device for upper limb amputees might be created.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
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    Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas foetus in a Mouse Vaginal Model (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-09
    Beschreibung: by Aparajita Chatterjee, Daniel M. Ratner, Christopher M. Ryan, Patricia J. Johnson, Barry R. O’Keefe, W. Evan Secor, Deborah J. Anderson, Phillips W. Robbins, John Samuelson Trichomonas vaginalis causes vaginitis and increases the risk of HIV transmission by heterosexual sex, while Tritrichomonas foetus causes premature abortion in cattle. Our goals were to determine the effects, if any, of anti-retroviral lectins, which are designed to prevent heterosexual transmission of HIV, on adherence of Trichomonas to ectocervical cells and on Tritrichomonas infections in a mouse model. We show that Trichomonas Asn-linked glycans ( N -glycans), like those of HIV, bind the mannose-binding lectin (MBL) that is part of the innate immune system. N -glycans of Trichomonas and Tritrichomonas bind anti-retroviral lectins (cyanovirin-N and griffithsin) and the 2G12 monoclonal antibody, each of which binds HIV N -glycans. Binding of cyanovirin-N appears to be independent of susceptibility to metronidazole, the major drug used to treat Trichomonas . Anti-retroviral lectins, MBL, and galectin-1 cause Trichomonas to self-aggregate and precipitate. The anti-retroviral lectins also increase adherence of ricin-resistant mutants, which are less adherent than parent cells, to ectocervical cell monolayers and to organotypic EpiVaginal tissue cells. Topical application of either anti-retroviral lectins or yeast N -glycans decreases by 40 to 70% the recovery of Tritrichomonas from the mouse vagina. These results, which are explained by a few simple models, suggest that the anti-retroviral lectins have a modest potential for preventing or treating human infections with Trichomonas .
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Educational Inequalities in Exit from Paid Employment among Dutch Workers: The Influence of Health, Lifestyle and Work (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-09
    Beschreibung: by Suzan J. W. Robroek, Anne Rongen, Coos H. Arts, Ferdy W. H. Otten, Alex Burdorf, Merel Schuring Background Individuals with lower socioeconomic status are at increased risk of involuntary exit from paid employment. To give sound advice for primary prevention in the workforce, insight is needed into the role of mediating factors between socioeconomic status and labour force participation. Therefore, it is aimed to investigate the influence of health status, lifestyle-related factors and work characteristics on educational differences in exit from paid employment. Methods 14,708 Dutch employees participated in a ten-year follow-up study during 1999–2008. At baseline, education, self-perceived health, lifestyle (smoking, alcohol, sports, BMI) and psychosocial (demands, control, rewards) and physical work characteristics were measured by questionnaire. Employment status was ascertained monthly based on tax records. The relation between education, health, lifestyle, work-characteristics and exit from paid employment through disability benefits, unemployment, early retirement and economic inactivity was investigated by competing risks regression analyses. The mediating effects of these factors on educational differences in exit from paid employment were tested using a stepwise approach. Results Lower educated workers were more likely to exit paid employment through disability benefits (SHR:1.84), unemployment (SHR:1.74), and economic inactivity (SHR:1.53) but not due to early retirement (SHR:0.92). Poor or moderate health, an unhealthy lifestyle, and unfavourable work characteristics were associated with disability benefits and unemployment, and an unhealthy lifestyle with economic inactivity. Educational differences in disability benefits were explained for 40% by health, 31% by lifestyle, and 12% by work characteristics. For economic inactivity and unemployment, up to 14% and 21% of the educational differences could be explained, particularly by lifestyle-related factors. Conclusions There are educational differences in exit from paid employment, which are partly mediated by health, lifestyle and work characteristics, particularly for disability benefits. Health promotion and improving working conditions seem important measures to maintain a productive workforce, particularly among workers with a low education.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Security Analysis and Improvement of ‘a More Secure Anonymous User Authentication Scheme for the Integrated EPR Information System’ (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-12
    Beschreibung: by SK Hafizul Islam, Muhammad Khurram Khan, Xiong Li Over the past few years, secure and privacy-preserving user authentication scheme has become an integral part of the applications of the healthcare systems. Recently, Wen has designed an improved user authentication system over the Lee et al.’s scheme for integrated electronic patient record (EPR) information system, which has been analyzed in this study. We have found that Wen’s scheme still has the following inefficiencies: (1) the correctness of identity and password are not verified during the login and password change phases; (2) it is vulnerable to impersonation attack and privileged-insider attack; (3) it is designed without the revocation of lost/stolen smart card; (4) the explicit key confirmation and the no key control properties are absent, and (5) user cannot update his/her password without the help of server and secure channel. Then we aimed to propose an enhanced two-factor user authentication system based on the intractable assumption of the quadratic residue problem (QRP) in the multiplicative group. Our scheme bears more securities and functionalities than other schemes found in the literature.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    GDSCalc: A Web-Based Application for Evaluating Discrete Graph Dynamical Systems (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-12
    Beschreibung: by Sherif H. Elmeligy Abdelhamid, Chris J. Kuhlman, Madhav V. Marathe, Henning S. Mortveit, S. S. Ravi Discrete dynamical systems are used to model various realistic systems in network science, from social unrest in human populations to regulation in biological networks. A common approach is to model the agents of a system as vertices of a graph, and the pairwise interactions between agents as edges. Agents are in one of a finite set of states at each discrete time step and are assigned functions that describe how their states change based on neighborhood relations. Full characterization of state transitions of one system can give insights into fundamental behaviors of other dynamical systems. In this paper, we describe a discrete graph dynamical systems (GDSs) application called GDSCalc for computing and characterizing system dynamics. It is an open access system that is used through a web interface. We provide an overview of GDS theory. This theory is the basis of the web application; i.e., an understanding of GDS provides an understanding of the software features, while abstracting away implementation details. We present a set of illustrative examples to demonstrate its use in education and research. Finally, we compare GDSCalc with other discrete dynamical system software tools. Our perspective is that no single software tool will perform all computations that may be required by all users; tools typically have particular features that are more suitable for some tasks. We situate GDSCalc within this space of software tools.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
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    Depth-Dependent Mineral Soil CO2 Production Processes: Sensitivity to Harvesting-Induced Changes in Soil Climate (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-12
    Beschreibung: by Lisa Kellman, Amy Myette, Hugo Beltrami Forest harvesting induces a step change in the climatic variables (temperature and moisture), that control carbon dioxide ( CO 2 ) production arising from soil organic matter decomposition within soils. Efforts to examine these vertically complex relationships in situ within soil profiles are lacking. In this study we examined how the climatic controls on CO 2 production change within vertically distinct layers of the soil profile in intact and clearcut forest soils of a humid temperate forest system of Atlantic Canada. We measured mineral soil temperature (0, 5, 10, 20, 50 and 100 cm depth) and moisture (0–15 cm and 30–60 cm depth), along with CO 2 surface efflux and subsurface concentrations (0, 2.5, 5, 10, 20, 35, 50, 75 and 100 cm depth) in 1 m deep soil pits at 4 sites represented by two forest-clearcut pairs over a complete annual cycle. We examined relationships between surface efflux at each site, and soil heat, moisture, and mineral soil CO 2 production. Following clearcut harvesting we observed increases in temperature through depth (1–2°C annually; often in excess of 4°C in summer and spring), alongside increases in soil moisture (30%). We observed a systematic breakdown in the expected exponential relationship between CO 2 production and heat with mineral soil depth, consistent with an increase in the role moisture plays in constraining CO 2 production. These findings should be considered in efforts to model and characterize mineral soil organic matter decomposition in harvested forest soils.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Protective Effect of Sevoflurane Postconditioning against Cardiac Ischemia/Reperfusion Injury via Ameliorating Mitochondrial Impairment, Oxidative Stress and Rescuing Autophagic Clearance (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-12
    Beschreibung: by Peng Yu, Jing Zhang, Shuchun Yu, Zhenzhong Luo, Fuzhou Hua, Linhui Yuan, Zhidong Zhou, Qin Liu, Xiaohong Du, Sisi Chen, Lieliang Zhang, Guohai Xu Background and Purpose Myocardial infarction leads to heart failure. Autophagy is excessively activated in myocardial ischemia/reperfusion (I/R) in rats. The aim of this study is to investigate whether the protection of sevoflurane postconditioning (SPC) in myocardial I/R is through restored impaired autophagic flux. Methods Except for the sham control (SHAM) group, each rat underwent 30 min occlusion of the left anterior descending coronary (LAD) followed by 2 h reperfusion. Cardiac infarction was determined by 2,3,5-triphenyltetrazolium chloride triazole (TTC) staining. Cardiac function was examined by hemodynamics and echocardiography. The activation of autophagy was evaluated by autophagosome accumulation, LC3 conversion and p62 degradation. Potential molecular mechanisms were investigated by immunoblotting, real-time PCR and immunofluorescence staining. Results SPC improved the hemodynamic parameters, cardiac dysfunction, histopathological and ultrastructural damages, and decreased myocardial infarction size after myocardial I/R injury ( P 〈 0.05 vs. I/R group). Compared with the cases in I/R group, myocardial ATP and NAD + content, mitochondrial function related genes and proteins, and the expressions of SOD2 and HO-1 were increased, while the expressions of ROS and Vimentin were decreased in the SPC group ( P 〈 0.05 vs. I/R group). SPC significantly activated Akt/mTOR signaling, and inhibited the formation of Vps34/Beclin1 complex via increasing expression of Bcl2 protein ( P 〈 0.05 vs. I/R group). SPC suppressed elevated expressions of LC3 II/I ratio, Beclin1, Atg5 and Atg7 in I/R rat, which indicated that SPC inhibited over-activation of autophagy, and promoted autophagosome clearance. Meanwhile, SPC significantly suppressed the decline of Opa1 and increases of Drp1 and Parkin induced by I/R injury ( P 〈 0.05 vs. I/R group). Moreover, SPC maintained the contents of ATP by reducing impaired mitochondria. Conclusion SPC protects rat hearts against I/R injury via ameliorating mitochondrial impairment, oxidative stress and rescuing autophagic clearance.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
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    Influential Factors on the Relative Age Effect in Alpine Ski Racing (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-09
    Beschreibung: by Lisa Müller, Erich Müller, Carolin Hildebrandt, Elmar Kornexl, Christian Raschner The relative age effect (RAE), which refers to an over-representation of selected athletes born early in the selection year, was proven to be present in alpine ski racing in all age categories at both national and international levels. However, the influential factors on, or the causal mechanisms of, the RAE are still unknown. Therefore, the aim of the present study was to examine three possible influential factors on the relative age effect in alpine skiing: physical performance, anthropometric characteristics and biological maturational status. The study included the investigation of 282 elite Austrian youth ski racers and 413 non-athletes (comparison group) of the same age (10–13 years) and region. Six physical performance tests were performed, body mass and height were assessed, and the age at peak height velocity (APHV) was calculated. A significant RAE was present in the ski racers. No differences were shown in the physical performance characteristics or in the calculated APHV between the relative age quarters. These results suggest that ski racers born in the last quarter can counteract the relative age disadvantages if they already present the same level of physical performance and maturational status as those born at the beginning of the year. The height and weight of ski racers born at the beginning of the year were significantly higher compared to the non-athletes, and ski racers born in relative age quarter 1 were taller and heavier compared to the ski racers of the other quarters. This indicates that the anthropometric characteristics influence the selection process in alpine ski racing, and that relatively older athletes are more likely to be selected if they exhibit advanced anthropometric characteristics.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Intrinsic Functional Connectivity in Salience and Default Mode Networks and Aberrant Social Processes in Youth at Ultra-High Risk for Psychosis (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-09
    Beschreibung: by Andrea Pelletier-Baldelli, Jessica A. Bernard, Vijay A. Mittal Social processes are key to navigating the world, and investigating their underlying mechanisms and cognitive architecture can aid in understanding disease states such as schizophrenia, where social processes are highly impacted. Evidence suggests that social processes are impaired in individuals at ultra high-risk for the development of psychosis (UHR). Understanding these phenomena in UHR youth may clarify disease etiology and social processes in a period that is characterized by significantly fewer confounds than schizophrenia. Furthermore, understanding social processing deficits in this population will help explain these processes in healthy individuals. The current study examined resting state connectivity of the salience (SN) and default mode networks (DMN) in association with facial emotion recognition (FER), an integral aspect of social processes, as well as broader social functioning (SF) in UHR individuals and healthy controls. Consistent with the existing literature, UHR youth were impaired in FER and SF when compared with controls. In the UHR group, we found increased connectivity between the SN and the medial prefrontal cortex, an area of the DMN relative to controls. In UHR youth, the DMN exhibited both positive and negative correlations with the somatosensory cortex/cerebellum and precuneus, respectively, which was linked with better FER performance. For SF, results showed that sensory processing links with the SN might be important in allowing for better SF for both groups, but especially in controls where sensory processing is likely to be unimpaired. These findings clarify how social processing deficits may manifest in psychosis, and underscore the importance of SN and DMN connectivity for social processing more generally.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Remote Sensing, Vol. 7, Pages 10184-10226: Multiple Stable States and Catastrophic Shifts in Coastal Wetlands: Progress, Challenges, and Opportunities in Validating Theory Using Remote Sensing and Other Methods (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-12
    Beschreibung: Multiple stable states are established in coastal tidal wetlands (marshes, mangroves, deltas, seagrasses) by ecological, hydrological, and geomorphological feedbacks. Catastrophic shifts between states can be induced by gradual environmental change or by disturbance events. These feedbacks and outcomes are key to the sustainability and resilience of vegetated coastlines, especially as modulated by human activity, sea level rise, and climate change. Whereas multiple stable state theory has been invoked to model salt marsh responses to sediment supply and sea level change, there has been comparatively little empirical verification of the theory for salt marshes or other coastal wetlands. Especially lacking is long-term evidence documenting if or how stable states are established and maintained at ecosystem scales. Laboratory and field-plot studies are informative, but of necessarily limited spatial and temporal scope. For the purposes of long-term, coastal-scale monitoring, remote sensing is the best viable option. This review summarizes the above topics and highlights the emerging promise and challenges of using remote sensing-based analyses to validate coastal wetland dynamic state theories. This significant opportunity is further framed by a proposed list of scientific advances needed to more thoroughly develop the field.
    Digitale ISSN: 2072-4292
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie
    Publiziert von MDPI Publishing
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    Future Internet, Vol. 7, Pages 294-306: Enhancing Educational Opportunities with Computer-Mediated Assessment Feedback (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-12
    Beschreibung: As internet technologies make their way into developing areas, so too does the possibility of education and training being delivered to the people living in those previously unserved areas. The growing catalogue of free, high quality courseware, when combined with the newly acquired means of delivery, creates the potential for millions of people in the developing world to acquire a good education. Yet a good education obviously requires more than simply delivering information; students must also receive high quality feedback on their assessments. They must be told how their performance compares with the ideal, and be shown how to close the gap between the two. However, delivering high quality feedback is labor-intensive, and therefore expensive, and has long been recognized as a problematic issue by educators. This paper outlines a case study that uses a Learning Management System (LMS) to efficiently deliver detailed feedback that is informed by the principles of best practice. We make the case that the efficiencies of this method allow for large-scale courses with thousands of enrolments that are accessible to developing and developed areas alike. We explore the question; is computer-mediated feedback delivery efficient and effective and might it be applied to large-scale courses at low-cost?
    Digitale ISSN: 1999-5903
    Thema: Informatik
    Publiziert von MDPI Publishing
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    Sustainability, Vol. 7, Pages 10854-10875: Review of Display Technologies Focusing on Power Consumption (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-12
    Beschreibung: This paper provides an overview of the main manufacturing technologies of displays, focusing on those with low and ultra-low levels of power consumption, which make them suitable for current societal needs. Considering the typified value obtained from the manufacturer’s specifications, four technologies—Liquid Crystal Displays, electronic paper, Organic Light-Emitting Display and Electroluminescent Displays—were selected in a first iteration. For each of them, several features, including size and brightness, were assessed in order to ascertain possible proportional relationships with the rate of consumption. To normalize the comparison between different display types, relative units such as the surface power density and the display frontal intensity efficiency were proposed. Organic light-emitting display had the best results in terms of power density for small display sizes. For larger sizes, it performs less satisfactorily than Liquid Crystal Displays in terms of energy efficiency.
    Digitale ISSN: 2071-1050
    Thema: Energietechnik
    Publiziert von MDPI Publishing
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    IJERPH, Vol. 12, Pages 9391-9407: Model Averaging for Improving Inference from Causal Diagrams (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-12
    Beschreibung: Model selection is an integral, yet contentious, component of epidemiologic research. Unfortunately, there remains no consensus on how to identify a single, best model among multiple candidate models. Researchers may be prone to selecting the model that best supports their a priori, preferred result; a phenomenon referred to as “wish bias”. Directed acyclic graphs (DAGs), based on background causal and substantive knowledge, are a useful tool for specifying a subset of adjustment variables to obtain a causal effect estimate. In many cases, however, a DAG will support multiple, sufficient or minimally-sufficient adjustment sets. Even though all of these may theoretically produce unbiased effect estimates they may, in practice, yield somewhat distinct values, and the need to select between these models once again makes the research enterprise vulnerable to wish bias. In this work, we suggest combining adjustment sets with model averaging techniques to obtain causal estimates based on multiple, theoretically-unbiased models. We use three techniques for averaging the results among multiple candidate models: information criteria weighting, inverse variance weighting, and bootstrapping. We illustrate these approaches with an example from the Pregnancy, Infection, and Nutrition (PIN) study. We show that each averaging technique returns similar, model averaged causal estimates. An a priori strategy of model averaging provides a means of integrating uncertainty in selection among candidate, causal models, while also avoiding the temptation to report the most attractive estimate from a suite of equally valid alternatives.
    Print ISSN: 1661-7827
    Digitale ISSN: 1660-4601
    Thema: Energietechnik , Medizin
    Publiziert von MDPI Publishing
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    IJERPH, Vol. 12, Pages 9375-9390: Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-12
    Beschreibung: The widespread, intentional and increasingly frequent chemical emplacement in the troposphere has gone unidentified and unremarked in the scientific literature for years. The author presents evidence that toxic coal combustion fly ash is the most likely aerosolized particulate sprayed by tanker-jets for geoengineering, weather-modification and climate-modification purposes and describes some of the multifold consequences on public health. Two methods are employed: (1) Comparison of 8 elements analyzed in rainwater, leached from aerosolized particulates, with corresponding elements leached into water from coal fly ash in published laboratory experiments, and (2) Comparison of 14 elements analyzed in dust collected outdoors on a high-efficiency particulate air (HEPA) filter with corresponding elements analyzed in un-leached coal fly ash material. The results show: (1) the assemblage of elements in rainwater and in the corresponding experimental leachate are essentially identical. At a 99% confidence interval, they have identical means (T-test) and identical variances (F-test); and (2) the assemblage of elements in the HEPA dust and in the corresponding average un-leached coal fly ash are likewise essentially identical. The consequences on public health are profound, including exposure to a variety of toxic heavy metals, radioactive elements, and neurologically-implicated chemically mobile aluminum released by body moisture in situ after inhalation or through transdermal induction.
    Print ISSN: 1661-7827
    Digitale ISSN: 1660-4601
    Thema: Energietechnik , Medizin
    Publiziert von MDPI Publishing
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    IJERPH, Vol. 12, Pages 9342-9356: Climate Change and Health on the U.S. Gulf Coast: Public Health Adaptation is Needed to Address Future Risks (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-12
    Beschreibung: The impacts of climate change on human health have been documented globally and in the United States. Numerous studies project greater morbidity and mortality as a result of extreme weather events and other climate-sensitive hazards. Public health impacts on the U.S. Gulf Coast may be severe as the region is expected to experience increases in extreme temperatures, sea level rise, and possibly fewer but more intense hurricanes. Through myriad pathways, climate change is likely to make the Gulf Coast less hospitable and more dangerous for its residents, and may prompt substantial migration from and into the region. Public health impacts may be further exacerbated by the concentration of people and infrastructure, as well as the region’s coastal geography. Vulnerable populations, including the very young, elderly, and socioeconomically disadvantaged may face particularly high threats to their health and well-being. This paper provides an overview of potential public health impacts of climate variability and change on the Gulf Coast, with a focus on the region’s unique vulnerabilities, and outlines recommendations for improving the region’s ability to minimize the impacts of climate-sensitive hazards. Public health adaptation aimed at improving individual, public health system, and infrastructure resilience is urgently needed to meet the challenges climate change may pose to the Gulf Coast in the coming decades.
    Print ISSN: 1661-7827
    Digitale ISSN: 1660-4601
    Thema: Energietechnik , Medizin
    Publiziert von MDPI Publishing
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    Sustainability, Vol. 7, Pages 10876-10894: Reforming China’s Pension Scheme for Urban Workers: Liquidity Gap and Policies’ Effects Forecasting (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-12
    Beschreibung: This study forecasts the liquidity gap in China’s pension scheme for urban workers in the context of an ageing population and the possible effects of recent governmental policies by constructing a basic pension model, including “old people”, “middle people” and “new people” and a simulation method. We find, firstly, that China’s liquidity gap of pension will reach its peak of approximately 13.11 trillion yuan in 2038. Subsequently, this gap will gradually decrease with growth in the mortality rate. Secondly, reasonable intervals for the replacement and contribution rates should be set at [0.417, 0.604] and [0.189, 0.262], respectively, to sustain China’s pension system. Thirdly, compared to increasing fiscal subsidies, an income doubling plan, raising the contribution rate, lowering the replacement rate and delaying the retirement age can significantly reduce the liquidity gap, although the policy costs are relatively high. A policy permitting families to have two children will increase the rate of reduction of the liquidity gap, but it cannot effectively narrow the gap at the peak moment.
    Digitale ISSN: 2071-1050
    Thema: Energietechnik
    Publiziert von MDPI Publishing
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    Algorithms, Vol. 8, Pages 632-644: Data Fusion Modeling for an RT3102 and Dewetron System Application in Hybrid Vehicle Stability Testing (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-13
    Beschreibung: More and more hybrid electric vehicles are driven since they offer such advantages as energy savings and better active safety performance. Hybrid vehicles have two or more power driving systems and frequently switch working condition, so controlling stability is very important. In this work, a two-stage Kalman algorithm method is used to fuse data in hybrid vehicle stability testing. First, the RT3102 navigation system and Dewetron system are introduced. Second, a modeling of data fusion is proposed based on the Kalman filter. Then, this modeling is simulated and tested on a sample vehicle, using Carsim and Simulink software to test the results. The results showed the merits of this modeling.
    Digitale ISSN: 1999-4893
    Thema: Informatik
    Publiziert von MDPI Publishing
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    Atmosphere, Vol. 6, Pages 1154-1174: The Impact of Selected Parameters on Visibility: First Results from a Long-Term Campaign in Warsaw, Poland (2015)
    MDPI Publishing
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    Publikationsdatum: 2015-08-13
    Beschreibung: The aim of this study was to investigate how atmospheric air pollutants and meteorological conditions affected atmospheric visibility in the largest Polish agglomeration. The correlation analysis, principal component analysis (PCA) and generalized regression models (GRMs) were used to accomplish this objective. The meteorological parameters (temperature, relative humidity, precipitation, wind speed and insolation) and concentrations of the air pollutants (PM10, SO2, NO2, CO and O3) were recorded in 2004–2013. The data came from the Ursynów-SGGW, MzWarszUrsynów and Okęcie monitoring stations, located in the south of Warsaw (Poland). It was shown that the PM10 concentration was the most important parameter affecting the visibility in Warsaw. The concentration, and indirectly the visibility, was mainly affected by the pollutant emission from the flat/building heating (combustion of various fuels). It changed intensively during the research period. There were also periods in which this emission type did not have a great influence on the pollutant concentrations (mainly PM10) and visibility. In such seasons, the research revealed the influence of the traffic emission and secondary aerosol formation processes on the visibility.
    Digitale ISSN: 2073-4433
    Thema: Geologie und Paläontologie
    Publiziert von MDPI Publishing
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    Length-Based Assessment of Coral Reef Fish Populations in the Main and Northwestern Hawaiian Islands (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-13
    Beschreibung: by Marc O. Nadon, Jerald S. Ault, Ivor D. Williams, Steven G. Smith, Gerard T. DiNardo The coral reef fish community of Hawaii is composed of hundreds of species, supports a multimillion dollar fishing and tourism industry, and is of great cultural importance to the local population. However, a major stock assessment of Hawaiian coral reef fish populations has not yet been conducted. Here we used the robust indicator variable “average length in the exploited phase of the population (L¯)”, estimated from size composition data from commercial fisheries trip reports and fishery-independent diver surveys, to evaluate exploitation rates for 19 Hawaiian reef fishes. By and large, the average lengths obtained from diver surveys agreed well with those from commercial data. We used the estimated exploitation rates coupled with life history parameters synthesized from the literature to parameterize a numerical population model and generate stock sustainability metrics such as spawning potential ratios (SPR). We found good agreement between predicted average lengths in an unfished population (from our population model) and those observed from diver surveys in the largely unexploited Northwestern Hawaiian Islands. Of 19 exploited reef fish species assessed in the main Hawaiian Islands, 9 had SPRs close to or below the 30% overfishing threshold. In general, longer-lived species such as surgeonfishes, the redlip parrotfish ( Scarus rubroviolaceus ), and the gray snapper ( Aprion virescens ) had the lowest SPRs, while short-lived species such as goatfishes and jacks, as well as two invasive species ( Lutjanus kasmira and Cephalopholis argus ), had SPRs above the 30% threshold.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Performance of Dutch Children on the Bayley III: A Comparison Study of US and Dutch Norms (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-13
    Beschreibung: by Leonie J. P. Steenis, Marjolein Verhoeven, Dave J. Hessen, Anneloes L. van Baar Background The Bayley Scales of Infant and Toddler Development-third edition (Bayley-III) are frequently used to assess early child development worldwide. However, the original standardization only included US children, and it is still unclear whether or not these norms are adequate for use in other populations. Recently, norms for the Dutch version of the Bayley-III (The Bayley-III-NL) were made. Scores based on Dutch and US norms were compared to study the need for population-specific norms. Methods Scaled scores based on Dutch and US norms were compared for 1912 children between 14 days and 42 months 14 days. Next, the proportions of children scoring 〈 1-SD and 〈 -2 SD based on the two norms were compared, to identify over- or under-referral for developmental delay resulting from non-population-based norms. Results Scaled scores based on Dutch norms fluctuated around values based on US norms on all subtests. The extent of the deviations differed across ages and subtests. Differences in means were significant across all five subtests (p 〈 .01) with small to large effect sizes ( η p 2 ) ranging from .03 to .26). Using the US instead of Dutch norms resulted in over-referral regarding gross motor skills, and under-referral regarding cognitive, receptive communication, expressive communication, and fine motor skills. Conclusions The Dutch norms differ from the US norms for all subtests and these differences are clinically relevant. Population specific norms are needed to identify children with low scores for referral and intervention, and to facilitate international comparisons of population data.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    A Pilot Study on Clinical and Neuroimaging Characteristics of Chinese Posterior Cortical Atrophy: Comparison with Typical Alzheimer’s Disease (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-13
    Beschreibung: by Xiao-Dan Wang, Hui Lu, Zhihong Shi, Li Cai, Shuai Liu, Shuling Liu, Tong Han, Ying Wang, Yuying Zhou, Xinping Wang, Shuo Gao, Yong Ji Posterior cortical atrophy (PCA) is a clinicoradiologic neurodegenerative syndrome characterized by predominant impairment of higher visual functions. Neuroimaging and neuropathological studies show that PCA is probably an atypical presentation of Alzheimer’s disease. However, in China PCA has rarely been studied and remains largely unknown. Our study therefore aimed to analyze the clinical manifestations and patterns of cerebral atrophy, amyloid beta deposition and regional glucose metabolism in Chinese PCA patients, comparing them directly with those of typical Alzheimer’s disease (TAD). Seven PCA patients, 6 TAD patients and 5 controls underwent neuropsychological assessment, MRI scan, 11 C-PIB PET scan and 18 F-FDG PET scan. Cerebral atrophy including ventricular enlargement, posterior atrophy and medial temporal lobe atrophy were evaluated with MRI. The uptake of 11 C-PIB was quantified at the voxel level using the standardized uptake value ratio. Comparisons of regional cerebral glucose metabolism were calculated with statistical parametric mapping. PCA patients showed significant impairment on visuospatial function in neuropsychological assessment. And PCA patients showed more severe posterior atrophy and less severe left medial temporal lobe atrophy compared with TAD patients. The data from 11 C-PIB PET scanning showed that amyloid beta deposition in PCA was comparable to TAD. Moreover, in PCA the results from 18 F-FDG PET scanning revealed significant hypometabolism in the temporoparietooccipital region and identified specific hypometabolism in the right occipital lobe, compared with TAD. Our study thus provides a preliminary view of PCA in Chinese patients. A further study with a larger number of subjects would be recommended to confirm these findings.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Reliability and Validity Study of Clinical Ultrasound Imaging on Lateral Curvature of Adolescent Idiopathic Scoliosis (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-13
    Beschreibung: by Q. Wang, M. Li, Edmond H. M. Lou, M. S. Wong Background Non-ionizing radiation imaging assessment has been advocated for the patients with adolescent idiopathic scoliosis (AIS). As one of the radiation-free methods, ultrasound imaging has gained growing attention in scoliosis assessment over the past decade. The center of laminae (COL) method has been proposed to measure the spinal curvature in the coronal plane of ultrasound image. However, the reliability and validity of this ultrasound method have not been validated in the clinical setting. Objectives To evaluate the reliability and validity of clinical ultrasound imaging on lateral curvature measurements of AIS with their corresponding magnetic resonance imaging (MRI) measurements. Methods Thirty curves (ranged 10.2°–68.2°) from sixteen patients with AIS were eligible for this study. The ultrasound scan was performed using a 3-D ultrasound unit within the same morning of MRI examination. Two researchers were involved in data collection of these two examinations. The COL method was used to measure the coronal curvature in ultrasound image, compared with the Cobb method in MRI. The intra- and inter-rater reliability of the COL method was evaluated by intra-class correlation coefficient (ICC). The validity of this method was analyzed by paired Student’s t -test, Bland–Altman statistics and Pearson correlation coefficient. The level of significance was set as 0.05. Results The COL method showed high intra- and inter-rater reliabilities (both with ICC (2, K) 〉0.9, p
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-13
    Beschreibung: by Yongkang Kim, Taesung Park Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants. It has been shown that most of the variants that were discovered by GWAS could only partially explain disease heritability. The explanation for this missing heritability is generally believed to be gene-gene (GG) or gene-environment (GE) interactions and other structural variants. Generalized multifactor dimensionality reduction (GMDR) has been proven to be reasonably powerful in detecting GG and GE interactions; however, its performance has been found to decline when outlying quantitative traits are present. This paper proposes a robust GMDR estimation method (based on the L-estimator and M-estimator estimation methods) in an attempt to reduce the effects caused by outlying traits. A comparison of robust GMDR with the original MDR based on simulation studies showed the former method to outperform the latter. The performance of robust GMDR is illustrated through a real GWA example consisting of 8,577 samples from the Korean population using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) level as a phenotype. Robust GMDR identified the KCNH1 gene to have strong interaction effects with other genes on the function of insulin secretion.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Item Anomaly Detection Based on Dynamic Partition for Time Series in Recommender Systems (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-13
    Beschreibung: by Min Gao, Renli Tian, Junhao Wen, Qingyu Xiong, Bin Ling, Linda Yang In recent years, recommender systems have become an effective method to process information overload. However, recommendation technology still suffers from many problems. One of the problems is shilling attacks-attackers inject spam user profiles to disturb the list of recommendation items. There are two characteristics of all types of shilling attacks: 1) Item abnormality: The rating of target items is always maximum or minimum; and 2) Attack promptness: It takes only a very short period time to inject attack profiles. Some papers have proposed item anomaly detection methods based on these two characteristics, but their detection rate, false alarm rate, and universality need to be further improved. To solve these problems, this paper proposes an item anomaly detection method based on dynamic partitioning for time series. This method first dynamically partitions item-rating time series based on important points. Then, we use chi square distribution (χ 2 ) to detect abnormal intervals. The experimental results on MovieLens 100K and 1M indicate that this approach has a high detection rate and a low false alarm rate and is stable toward different attack models and filler sizes.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Budgetary Impact of Treating Acute Promyelocytic Leukemia Patients with First-Line Arsenic Trioxide and Retinoic Acid from an Italian Payer Perspective (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
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    Publikationsdatum: 2015-08-13
    Beschreibung: by Morgan Kruse, Rebecca Wildner, Gisoo Barnes, Monique Martin, Udo Mueller, Francesco Lo-Coco, Ashutosh Pathak The objective of this study was to estimate the net cost of arsenic trioxide (ATO) added to all- trans retinoic acid (ATRA) compared to ATRA plus chemotherapy when used in first-line acute promyelocytic leukemia (APL) treatment for low to intermediate risk patients from the perspective of the overall Italian healthcare systemA Markov model was developed with 3 health states: stable disease, disease event and death. Each month, patients could move from stable to disease event or die from either state. After a disease event, patients discontinued initial treatment and switched to the other regimen as second-line therapy. Treatment regimens, efficacy and adverse events were derived from published sources and expert opinion; unit costs were collected from standard Italian sources. Clinical outcomes and costs for pre-ATO and post-ATO scenarios were combined with population and product utilization information to calculate the total budgetary impact using a 3-year time horizon; one-way sensitivity analyses were conducted. Three-year cumulative pharmacy costs for ATO+ATRA were €46,700 per-patient versus €6,500 for ATRA+chemotherapy; however, medical costs for ATO+ATRA were €12,300 per-patient versus €30,200 for ATRA+chemotherapy. The total budgetary impact was estimated to be an additional €127,300, €312,500 and €477,800 in the first, second and third years, respectively. The model was most sensitive to changes in the cost of the ATO+ATRA regimen during the consolidation phase. Budgetary impact models are valuable to payers making formulary decisions regarding the access and affordability of new medicines. The cost of treatment analysis showed that pharmacy costs for ATO+ATRA were higher than for ATRA+chemotherapy, while all other evaluated costs were lower for ATO+ATRA treated patients. The average budgetary impact was €305,900 per year overall, representing a 3.5% increase. Further research is needed to determine the cost-effectiveness of ATO+ATRA compared to the current first-line standard of care in APL.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    DAPK1 Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: by Antonella Agodi, Martina Barchitta, Annalisa Quattrocchi, Andrea Maugeri, Manlio Vinciguerra Objective The Death-Associated Protein Kinase 1 ( DAPK1 ) gene has been frequently investigated in cervical cancer (CC). The aim of the present study was to carry out a systematic review and a meta-analysis in order to evaluate DAPK1 promoter methylation as an epigenetic marker for CC risk. Methods A systematic literature search was carried out. The Cochrane software package Review Manager 5.2 was used. The fixed-effects or random-effects models, according to heterogeneity across studies, were used to calculate odds ratios (ORs) and 95% Confidence Intervals (CIs). Furthermore, subgroup analyses were conducted by histological type, assays used to evaluate DAPK1 promoter methylation, and control sample source. Results A total of 20 papers, published between 2001 and 2014, on 1929 samples, were included in the meta-analysis. DAPK1 promoter methylation was associated with an increased CC risk based on the random effects model (OR: 21.20; 95%CI = 11.14–40.35). Omitting the most heterogeneous study, the between study heterogeneity decreased and the association increased (OR: 24.13; 95% CI = 15.83–36.78). The association was also confirmed in all the subgroups analyses. Conclusions A significant strong association between DAPK1 promoter methylation and CC was shown and confirmed independently by histological tumor type, method used to evaluate methylation and source of control samples. Methylation markers may have value in early detection of CC precursor lesions, provide added reassurances of safety for women who are candidates for less frequent screens, and predict outcomes of women infected with human papilloma virus.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
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    Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation (2015)
    Public Library of Science (PLoS)
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    Publikationsdatum: 2015-08-13
    Beschreibung: by Yufeng Huang, Chuchu Wang, Yufeng Yao, Xiaoyu Zuo, Shanshan Chen, Chengqi Xu, Hongfu Zhang, Qiulun Lu, Le Chang, Fan Wang, Pengxia Wang, Rongfeng Zhang, Zhenkun Hu, Qixue Song, Xiaowei Yang, Cong Li, Sisi Li, Yuanyuan Zhao, Qin Yang, Dan Yin, Xiaojing Wang, Wenxia Si, Xiuchun Li, Xin Xiong, Dan Wang, Yuan Huang, Chunyan Luo, Jia Li, Jingjing Wang, Jing Chen, Longfei Wang, Li Wang, Meng Han, Jian Ye, Feifei Chen, Jingqiu Liu, Ying Liu, Gang Wu, Bo Yang, Xiang Cheng, Yuhua Liao, Yanxia Wu, Tie Ke, Qiuyun Chen, Xin Tu, Robert Elston, Shaoqi Rao, Yanzong Yang, Yunlong Xia, Qing K. Wang Atrial fibrillation (AF) is the most common cardiac arrhythmia at the clinic. Recent GWAS identified several variants associated with AF, but they account for
    Print ISSN: 1553-7390
    Digitale ISSN: 1553-7404
    Thema: Biologie
    Publiziert von Public Library of Science (PLoS)
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    Remote Sensing, Vol. 7, Pages 10295-10320: Mapping Aquatic Vegetation in a Large, Shallow Eutrophic Lake: A Frequency-Based Approach Using Multiple Years of MODIS Data (2015)
    MDPI Publishing
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: Aquatic vegetation serves many important ecological and socioeconomic functions in lake ecosystems. The presence of floating algae poses difficulties for accurately estimating the distribution of aquatic vegetation in eutrophic lakes. We present an approach to map the distribution of aquatic vegetation in Lake Taihu (a large, shallow eutrophic lake in China) and reduce the influence of floating algae on aquatic vegetation mapping. Our approach involved a frequency analysis over a 2003–2013 time series of the floating algal index (FAI) based on moderate-resolution imaging spectroradiometer (MODIS) data. Three phenological periods were defined based on the vegetation presence frequency (VPF) and the growth of algae and aquatic vegetation: December and January composed the period of wintering aquatic vegetation; February and March composed the period of prolonged coexistence of algal blooms and wintering aquatic vegetation; and June to October was the peak period of the coexistence of algal blooms and aquatic vegetation. By comparing and analyzing the satellite-derived aquatic vegetation distribution and 244 in situ measurements made in 2013, we established a FAI threshold of −0.025 and VPF thresholds of 0.55, 0.45 and 0.85 for the three phenological periods. We validated the accuracy of our approach by comparing the results between the satellite-derived maps and the in situ results obtained from 2008–2012. The overall classification accuracy was 87%, 81%, 77%, 88% and 73% in the five years from 2008–2012, respectively. We then applied the approach to the MODIS images from 2003–2013 and obtained the total area of the aquatic vegetation, which varied from 265.94 km2 in 2007 to 503.38 km2 in 2008, with an average area of 359.62 ± 69.20 km2 over the 11 years. Our findings suggest that (1) the proposed approach can be used to map the distribution of aquatic vegetation in eutrophic algae-rich waters and (2) dramatic changes occurred in the distribution of aquatic vegetation in Lake Taihu during the 11-year study.
    Digitale ISSN: 2072-4292
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie
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  • 79
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    Sensors, Vol. 15, Pages 19709-19722: High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications (2015)
    MDPI Publishing
    In: Sensors
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: Diffuse Correlation Spectroscopy (DCS) is a well-established optical technique that has been used for non-invasive measurement of blood flow in tissues. Instrumentation for DCS includes a correlation device that computes the temporal intensity autocorrelation of a coherent laser source after it has undergone diffuse scattering through a turbid medium. Typically, the signal acquisition and its autocorrelation are performed by a correlation board. These boards have dedicated hardware to acquire and compute intensity autocorrelations of rapidly varying input signal and usually are quite expensive. Here we show that a Raspberry Pi minicomputer can acquire and store a rapidly varying time-signal with high fidelity. We show that this signal collected by a Raspberry Pi device can be processed numerically to yield intensity autocorrelations well suited for DCS applications. DCS measurements made using the Raspberry Pi device were compared to those acquired using a commercial hardware autocorrelation board to investigate the stability, performance, and accuracy of the data acquired in controlled experiments. This paper represents a first step toward lowering the instrumentation cost of a DCS system and may offer the potential to make DCS become more widely used in biomedical applications.
    Digitale ISSN: 1424-8220
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
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  • 80
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    Sensors, Vol. 15, Pages 19723-19749: An Auto-Tuning PI Control System for an Open-Circuit Low-Speed Wind Tunnel Designed for Greenhouse Technology (2015)
    MDPI Publishing
    In: Sensors
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: Wind tunnels are a key experimental tool for the analysis of airflow parameters in many fields of application. Despite their great potential impact on agricultural research, few contributions have dealt with the development of automatic control systems for wind tunnels in the field of greenhouse technology. The objective of this paper is to present an automatic control system that provides precision and speed of measurement, as well as efficient data processing in low-speed wind tunnel experiments for greenhouse engineering applications. The system is based on an algorithm that identifies the system model and calculates the optimum PI controller. The validation of the system was performed on a cellulose evaporative cooling pad and on insect-proof screens to assess its response to perturbations. The control system provided an accuracy of 〈0.06 m·s‾1 for airflow speed and 〈0.50 Pa for pressure drop, thus permitting the reproducibility and standardization of the tests. The proposed control system also incorporates a fully-integrated software unit that manages the tests in terms of airflow speed and pressure drop set points.
    Digitale ISSN: 1424-8220
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Publiziert von MDPI Publishing
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  • 81
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    Sensors, Vol. 15, Pages 19768-19782: UWB Wind Turbine Blade Deflection Sensing for Wind Energy Cost Reduction (2015)
    MDPI Publishing
    In: Sensors
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: A new application of utilizing ultra-wideband (UWB) technology to sense wind turbine blade deflections is introduced in this paper for wind energy cost reduction. The lower UWB band of 3.1–5.3 GHz is applied. On each blade, there will be one UWB blade deflection sensing system, which consists of two UWB antennas at the blade root and one UWB antenna at the blade tip. The detailed topology and challenges of this deflection sensing system are addressed. Due to the complexity of the problem, this paper will first realize the on-blade UWB radio link in the simplest case, where the tip antenna is situated outside (and on the surface of) a blade tip. To investigate this case, full-blade time-domain measurements are designed and conducted under different deflections. The detailed measurement setups and results are provided. If the root and tip antenna locations are properly selected, the first pulse is always of sufficient quality for accurate estimations under different deflections. The measured results reveal that the blade tip-root distance and blade deflection can be accurately estimated in the complicated and lossy wireless channels around a wind turbine blade. Some future research topics on this application are listed finally.
    Digitale ISSN: 1424-8220
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Publiziert von MDPI Publishing
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  • 82
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    Sensors, Vol. 15, Pages 19750-19767: Shaft Diameter Measurement Using Structured Light Vision (2015)
    MDPI Publishing
    In: Sensors
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: A method for measuring shaft diameters is presented using structured light vision measurement. After calibrating a model of the structured light measurement, a virtual plane is established perpendicular to the measured shaft axis and the image of the light stripe on the shaft is projected to the virtual plane. On the virtual plane, the center of the measured shaft is determined by fitting the projected image under the geometrical constraints of the light stripe, and the shaft diameter is measured by the determined center and the projected image. Experiments evaluated the measuring accuracy of the method and the effects of some factors on the measurement are analyzed.
    Digitale ISSN: 1424-8220
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Publiziert von MDPI Publishing
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  • 83
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    Agronomy, Vol. 5, Pages 363-373: Cotton Water Use Efficiency under Two Different Deficit Irrigation Scheduling Methods (2015)
    MDPI
    In: Agronomy
    Details
    Publikationsdatum: 2015-08-14
    Beschreibung: Declines in Ogallala aquifer levels used for irrigation has prompted research to identify methods for optimizing water use efficiency (WUE) of cotton (Gossypium hirsutum L). In this experiment, conducted at Lubbock, TX, USA in 2014, our objective was to test two canopy temperature based stress indices, each at two different irrigation trigger set points: the Stress Time (ST) method with irrigation triggers set at 5.5 (ST_5.5) and 8.5 h (ST_8.5) and the Crop Water Stress Index (CWSI) method with irrigation triggers set at 0.3 (CWSI_0.3) and 0.6 (CWSI_0.6). When these irrigation triggers were exceeded on a given day, the crop was deficit irrigated with 5 mm of water via subsurface drip tape. Also included in the experimental design were a well-watered (WW) control irrigated at 110% of potential evapotranspiration and a dry land (DL) treatment that relied on rainfall only. Seasonal crop water use ranged from 353 to 625 mm across these six treatments. As expected, cotton lint yield increased with increasing crop water use but lint yield WUE displayed asignificant (p ≤ 0.05) peak near 3.6 to 3.7 kg ha−1 mm−1 for the ST_5.5 and CWSI_0.3 treatments, respectively. Our results suggest that WUE may be optimized in cotton with less water than that needed for maximum lint yield.
    Digitale ISSN: 2073-4395
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Wirtschaftswissenschaften
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  • 84
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    Water, Vol. 7, Pages 4427-4445: Impacts of Land Use on Surface Water Quality in a Subtropical River Basin: A Case Study of the Dongjiang River Basin, Southeastern China (2015)
    MDPI Publishing
    In: Water
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: Understanding the relationship between land use and surface water quality is necessary for effective water management. We estimated the impacts of catchment-wide land use on water quality during the dry and rainy seasons in the Dongjiang River basin, using remote sensing, geographic information systems and multivariate statistical techniques. The results showed that the 83 sites can be divided into three groups representing different land use types: forest, agriculture and urban. Water quality parameters exhibited significant variations between the urban-dominated and forest-dominated sites. The proportion of forested land was positively associated with dissolved oxygen concentration but negatively associated with water temperature, electrical conductivity, permanganate index, total phosphorus, total nitrogen, ammonia nitrogen, nitrate nitrogen and chlorophyll-a. The proportion of urban land was strongly positively associated with total nitrogen and ammonia nitrogen concentrations. Forested and urban land use had stronger impacts on water quality in the dry season than in the rainy season. However, agricultural land use did not have a significant impact on water quality. Our study indicates that urban land use was the key factor affecting water quality change, and limiting point-source waste discharge in urban areas during the dry season would be critical for improving water quality in the study area.
    Digitale ISSN: 2073-4441
    Thema: Energietechnik
    Publiziert von MDPI Publishing
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  • 85
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    Water, Vol. 7, Pages 4385-4408: Fractal Dimension of Cohesive Sediment Flocs at Steady State under Seven Shear Flow Conditions (2015)
    MDPI Publishing
    In: Water
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: The morphological properties of kaolin flocs were investigated in a Couette-flow experiment at the steady state under seven shear flow conditions (shear rates of 5.36, 9.17, 14, 24, 31, 41 and 53 s−1). These properties include a one-dimensional (1-D) fractal dimension (D1), a two-dimensional (2-D) fractal dimension (D2), a perimeter-based fractal dimension (Dpf) and an aspect ratio (AR). They were calculated based on the projected area (A), equivalent size, perimeter (P) and length (L) of the major axis of the floc determined through sample observation and an image analysis system. The parameter D2, which characterizes the relationship between the projected area and the length of the major axis using a power function, , increased from 1.73 ± 0.03, 1.72 ± 0.03, and 1.75 ± 0.04 in the low shear rate group (G = 5.36, 9.17, and 14 s−1) to 1.92 ± 0.03, 1.82 ± 0.02, 1.85 ± 0.02, and 1.81 ± 0.02 in the high shear rate group (24, 31, 41 and 53 s−1), respectively. The parameter D1 characterizes the relationship between the perimeter and length of the major axis by the function  and decreased from 1.52 ± 0.02, 1.48 ± 0.02, 1.55 ± 0.02, and 1.63 ± 0.02 in the low shear group (5.36, 9.17, 14 and 24 s−1) to 1.45 ± 0.02, 1.39 ± 0.02, and 1.39 ± 0.02 in the high shear group (31, 41 and 53 s−1), respectively. The results indicate that with increasing shear rates, the flocs become less elongated and that their boundary lines become tighter and more regular, caused by more breakages and possible restructurings of the flocs. The parameter Dpf, which is related to the perimeter and the projected area through the function , decreased as the shear rate increased almost linearly. The parameter AR, which is the ratio of the length of the major axis and equivalent diameter, decreased from 1.56, 1.59, 1.53 and 1.51 in the low shear rate group to 1.43, 1.47 and 1.48 in the high shear rate group. These changes in Dpf and AR show that the flocs become less convoluted and more symmetrical and that their boundaries become smoother and more regular in the high shear rate group than in the low shear rate group due to breakage and possible restructuring processes. To assess the effects of electrolyte and sediment concentration, 0.1 mol/L calcium chloride (CaCl2) and initial sediment concentration from 7.87 × 10−5 to 1.57 × 10−5 were used in this preliminary study. The addition of electrolyte and increasing sediment concentration could produce more symmetrical flocs with less convoluted and simpler boundaries. In addition, some new information on the temporal variation of the median size of the flocs during the flocculation process is presented.
    Digitale ISSN: 2073-4441
    Thema: Energietechnik
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  • 86
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    Climate, Vol. 3, Pages 578-626: Rainfall: Features and Variations over Saudi Arabia, A Review (2015)
    MDPI
    In: Climate
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: The Saudi Arabia (SA) climate varies greatly, depending on the geography and the season. According to K ppen and Geiger, the climates of SA is “desert climate”. The analysis of the seasonal rainfall detects that spring and winter seasons have the highestrainfall incidence, respectively. Through the summer,small quantities of precipitation are observed, while autumn received more precipitation more than summer season considering the total annual rainfall. In all seasons, the SW area receives rainfall, with a maximum in spring, whereas in the summer season, the NE and NW areas receive very little quantities of precipitation. The Rub Al-Khali (the SE region) is almost totally dry. The maximum amount of annual rainfall does not always happen at the highest elevation. Therefore, the elevation is not the only factor in rainfall distribution.A great inter-annual change in the rainfall over the SA for the period (1978–2009) is observed. In addition, in the same period, a linear decreasing trend is found in the observed rainfall, whilst in the recent past (1994–2009) a statistically significant negative trend is observed. In the Southern part of the Arabian Peninsula (AP) and along the coast of the Red Sea, it is interesting to note that rainfall increased, whilst it decreased over most areas of SA during the 2000–2009 decade, compared to 1980–1989.Statistical and numerical models are used to predict rainfall over Saudi Arabia (SA). The statistical models based on stochastic models of ARIMA and numerical models based on Providing Regional Climates for Impact Studies of Hadley Centre (PRECIS). Climate and its qualitative character and quantified range of possible future changes are investigated. The annual total rainfall decreases in most regions of the SA and only increases in the south. The summertime precipitation will be the highest between other seasons over the southern, the southwestern provinces and Asir mountains, while the wintertime rainfall will remain the lowest.The climate in the SA is instructed by the El Niño Southern Oscillation (ENSO) and other circulations such as centers of high and low pressure, the North Atlantic Oscillation (NAO) and SOI. Strength and oscillation of subtropical jet stream play a big role in pulling hot, dry air masses of SA.
    Digitale ISSN: 2225-1154
    Thema: Energietechnik , Geologie und Paläontologie
    Publiziert von MDPI
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  • 87
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    Energies, Vol. 8, Pages 8594-8612: A Real-Time Joint Estimator for Model Parameters and State of Charge of Lithium-Ion Batteries in Electric Vehicles (2015)
    MDPI Publishing
    In: Energies
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    Publikationsdatum: 2015-08-13
    Beschreibung: Accurate state of charge (SoC) estimation of batteries plays an important role in promoting the commercialization of electric vehicles. The main work to be done in accurately determining battery SoC can be summarized in three parts. (1) In view of the model-based SoC estimation flow diagram, the n-order resistance-capacitance (RC) battery model is proposed and expected to accurately simulate the battery’s major time-variable, nonlinear characteristics. Then, the mathematical equations for model parameter identification and SoC estimation of this model are constructed. (2) The Akaike information criterion is used to determine an optimal tradeoff between battery model complexity and prediction precision for the n-order RC battery model. Results from a comparative analysis show that the first-order RC battery model is thought to be the best based on the Akaike information criterion (AIC) values. (3) The real-time joint estimator for the model parameter and SoC is constructed, and the application based on two battery types indicates that the proposed SoC estimator is a closed-loop identification system where the model parameter identification and SoC estimation are corrected mutually, adaptively and simultaneously according to the observer values. The maximum SoC estimation error is less than 1% for both battery types, even against the inaccurate initial SoC.
    Digitale ISSN: 1996-1073
    Thema: Energietechnik
    Publiziert von MDPI Publishing
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  • 88
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    Energies, Vol. 8, Pages 8516-8536: An Iterative Method to Derive the Equivalent Centrifugal Compressor Performance at Various Operating Conditions: Part II: Modeling of Gas Properties Impact (2015)
    MDPI Publishing
    In: Energies
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: This is the second part of a study conducted to model the aerothermodynamic impact of suction parameters and gas properties on a multi-stage centrifugal compressor’s performance. A new iterative method has been developed in the first part to derive the equivalent performance at various operating conditions. This approach has been validated to predict the compressor map at different suction pressures and temperatures using the design characteristics as reference values. A further case is included in this paper in order to emphasize the validity of the developed approach to obtain the performance characteristics at various gas compositions. The provided example shows that the performance parameters at different gas mixtures can be predicted to within ±1.34%. Furthermore, the conducted optimization in this paper reveals that the proposed method can be applied for the compressor design evaluation corresponding to the expected variation in suction conditions. Moreover, the examined case study demonstrates the effect of gas properties’ variation on the operating point and aerodynamic stability of the entire compression system. In order to achieve that, a simple approach has been established to assess the contribution of gas properties’ variation to the inefficient and unstable compressor performance based on the available operational data.
    Digitale ISSN: 1996-1073
    Thema: Energietechnik
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  • 89
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    Energies, Vol. 8, Pages 8537-8561: Torque Distribution Algorithm for an Independently Driven Electric Vehicle Using a Fuzzy Control Method (2015)
    MDPI Publishing
    In: Energies
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: The in-wheel electric vehicle is expected to be a popular next-generation vehicle because an in-wheel system can simplify the powertrain and improve driving performance. In addition, it also has an advantage in that it maximizes driving efficiency through independent torque control considering the motor efficiency. However, there is an instability problem if only the driving torque is controlled in consideration of only the motor efficiency. In this paper, integrated torque distribution strategies are proposed to overcome these problems. The control algorithm consists of various strategies for optimizing driving efficiency, satisfying driver demands, and considering tire slip and vehicle cornering. Fuzzy logic is used to determine the appropriate timing of intervention for each distribution strategy. A performance simulator for in-wheel electric vehicles was developed by using MATLAB/Simulink and CarSim to validate the control strategies. From simulation results under complex driving conditions, the proposed algorithm was verified to improve both the driving stability and fuel economy of the in-wheel vehicle.
    Digitale ISSN: 1996-1073
    Thema: Energietechnik
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  • 90
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    Energies, Vol. 8, Pages 8482-8496: Measurements of the Aerodynamic Normal Forces on a 12-kW Straight-Bladed Vertical Axis Wind Turbine (2015)
    MDPI Publishing
    In: Energies
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: The knowledge of unsteady forces is necessary when designing vertical axis wind turbines (VAWTs). Measurement data for turbines operating at an open site are still very limited. The data obtained from wind tunnels or towing tanks can be used, but have limited applicability when designing large-scale VAWTs. This study presents experimental data on the normal forces of a 12-kW straight-bladed VAWT operated at an open site north of Uppsala, Sweden. The normal forces are measured with four single-axis load cells. The data are obtained for a wide range of tip speed ratios: from 1.7 to 4.6. The behavior of the normal forces is analyzed. The presented data can be used in validations of aerodynamic models and the mechanical design for VAWTs.
    Digitale ISSN: 1996-1073
    Thema: Energietechnik
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  • 91
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    Energies, Vol. 8, Pages 8497-8515: An Iterative Method to Derive the Equivalent Centrifugal Compressor Performance at Various Operating Conditions: Part I: Modelling of Suction Parameters Impact (2015)
    MDPI Publishing
    In: Energies
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: This paper introduces a new iterative method to predict the equivalent centrifugal compressor performance at various operating conditions. The presented theoretical analysis and empirical correlations provide a novel approach to derive the entire compressor map corresponding to various suction conditions without a prior knowledge of the detailed geometry. The efficiency model was derived to reflect the impact of physical gas properties, Mach number, and flow and work coefficients. One of the main features of the developed technique is the fact that it considers the variation in the gas properties and stage efficiency which makes it appropriate with hydrocarbons. This method has been tested to predict the performance of two multistage centrifugal compressors and the estimated characteristics are compared with the measured data. The carried comparison revealed a good matching with the actual values, including the stable operation region limits. Furthermore, an optimization study was conducted to investigate the influences of suction conditions on the stage efficiency and surge margin. Moreover, a new sort of presentation has been generated to obtain the equivalent performance characteristics for a constant discharge pressure operation at variable suction pressure and temperature working conditions. A further validation is included in part two of this study in order to evaluate the prediction capability of the derived model at various gas compositions.
    Digitale ISSN: 1996-1073
    Thema: Energietechnik
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  • 92
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    Energies, Vol. 8, Pages 8562-8572: Gasification of a Dried Sewage Sludge in a Laboratory Scale Fixed Bed Reactor (2015)
    MDPI Publishing
    In: Energies
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    Publikationsdatum: 2015-08-13
    Beschreibung: This paper presents an investigation of sewage sludge gasification in a fixed bed gasifier. Experiments were conducted on a laboratory scale fixed bed gasifier. In the experiments, two types of dried sewage sludge were tested and their properties were analysed. Parameters such as air ratio λ = 0.12 to 0.27, gasification agent temperature t = 50 to 250 °C and gasification agent composition ( = 0.21 and  > 0.21) were found to influence on temperature distribution, syngas Lower Heating Value (LHV) and syngas composition. The results indicate that the syngas LHV was found to decrease with increased air ratio for all analyzed cases: cold and preheated air and cold enriched air. The increase in the percentage of the main combustible components was accompanied by a decrease in the concentration of carbon dioxide. Increasing oxygen concentration increased the temperature, which tended to favor the formation of smaller molecules in the gas mixture. Thus, the enriched air medium produced a gas with a higher LHV. In contrast to conventional gasification, gasification process with gasification agent preheating causes that the flux of heat necessary to support endothermic gasification reactions is producing more effective. Air preheating causes increases hydrogen and carbon monoxide production.
    Digitale ISSN: 1996-1073
    Thema: Energietechnik
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  • 93
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    Entropy, Vol. 17, Pages 5811-5828: Combined Power Quality Disturbances Recognition Using Wavelet Packet Entropies and S-Transform (2015)
    MDPI Publishing
    In: Entropy
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: Aiming at the combined power quality +disturbance recognition, an automated recognition method based on wavelet packet entropy (WPE) and modified incomplete S-transform (MIST) is proposed in this paper. By combining wavelet packet Tsallis singular entropy, energy entropy and MIST, a 13-dimension vector of different power quality (PQ) disturbances including single disturbances and combined disturbances is extracted. Then, a ruled decision tree is designed to recognize the combined disturbances. The proposed method is tested and evaluated using a large number of simulated PQ disturbances and some real-life signals, which include voltage sag, swell, interruption, oscillation transient, impulsive transient, harmonics, voltage fluctuation and their combinations. In addition, the comparison of the proposed recognition approach with some existing techniques is made. The experimental results show that the proposed method can effectively recognize the single and combined PQ disturbances.
    Digitale ISSN: 1099-4300
    Thema: Chemie und Pharmazie , Physik
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  • 94
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    Entropy, Vol. 17, Pages 5799-5810: Entropy Bounds and Field Equations (2015)
    MDPI Publishing
    In: Entropy
    Details
    Publikationsdatum: 2015-08-13
    Beschreibung: For general metric theories of gravity, we compare the approach that describes/derives the field equations of gravity as a thermodynamic identity with the one which looks at them from entropy bounds. The comparison is made through the consideration of the matter entropy flux across (Rindler) horizons, studied by making use of the notion of a limiting thermodynamic scale l* of matter, previously introduced in the context of entropy bounds. In doing this: (i) a bound for the entropy of any lump of matter with a given energy-momentum tensor Tab is considered, in terms of a quantity, which is independent of the theory of gravity that we use; this quantity is the variation of the Clausius entropy of a suitable horizon when the element of matter crosses it; (ii) by making use of the equations of motion of the theory, the same quantity is then expressed as the variation of Wald’s entropy of that horizon (and this leads to a generalized form of the generalized covariant entropy bound, applicable to general diffeomorphism-invariant theories of gravity); and (iii) a notion of l* for horizons, as well as an expression for it, is given.
    Digitale ISSN: 1099-4300
    Thema: Chemie und Pharmazie , Physik
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  • 95
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    Forests, Vol. 6, Pages 2785-2798: Exploration of Optimal Agricultural Practices and Seedling Types for Establishing Poplar Plantations (2015)
    MDPI Publishing
    In: Forests
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    Publikationsdatum: 2015-08-14
    Beschreibung: Controlling competing vegetation during early growth is one of the most important practices for the successful establishment of poplar plantations. Today, most poplar plantations in temperate regions are established on abandoned marginal agricultural land where competing vegetation is usually present during the first years after planting. Thus, the objective of this study was to examine how the growth of two kinds of poplar planting materials, un-rooted cuttings and bare-rooted seedlings was influenced by different vegetation control and soil preparation practices. Across treatments, un-rooted cuttings grew more rapidly than the bare-rooted seedlings. Our results also show that mulching with a degradable carpet or permanent polyethylene plastic increased seedling growth to a similar extent and more strongly in the cases of no treatment (in control plots). In addition, the results suggest that soil preparation in the mulched area favored seedling growth, but this effect was restricted to the first year after planting. These findings indicate that optimal practices for establishing poplar plantations on former agricultural land include planting un-rooted cuttings in prepared soil and mulching.
    Digitale ISSN: 1999-4907
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
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  • 96
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    IJGI, Vol. 4, Pages 1389-1422: A Volunteered Geographic Information Framework to Enable Bottom-Up Disaster Management Platforms (2015)
    MDPI Publishing
    Details
    Publikationsdatum: 2015-08-14
    Beschreibung: Recent disasters, such as the 2010 Haiti earthquake, have drawn attention to the potential role of citizens as active information producers. By using location-aware devices such as smartphones to collect geographic information in the form of geo-tagged text, photos, or videos, and sharing this information through online social media, such as Twitter, citizens create Volunteered Geographic Information (VGI). To effectively use this information for disaster management, we developed a VGI framework for the discovery of VGI. This framework consists of four components: (i) a VGI brokering module to provide a standard service interface to retrieve VGI from multiple resources based on spatial, temporal, and semantic parameters; (ii) a VGI quality control component, which employs semantic filtering and cross-referencing techniques to evaluate VGI; (iii) a VGI publisher module, which uses a service-based delivery mechanism to disseminate VGI, and (iv) a VGI discovery component to locate, browse, and query metadata about available VGI datasets. In a case study we employed a FOSS (Free and Open Source Software) strategy, open standards/specifications, and free/open data to show the utility of the framework. We demonstrate that the framework can facilitate data discovery for disaster management. The addition of quality metrics and a single aggregated source of relevant crisis VGI will allow users to make informed policy choices that could save lives, meet basic humanitarian needs earlier, and perhaps limit environmental and economic damage.
    Digitale ISSN: 2220-9964
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geologie und Paläontologie
    Publiziert von MDPI Publishing im Namen von International Society for Photogrammetry and Remote Sensing (ISPRS).
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
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    IJERPH, Vol. 12, Pages 9536-9541: Readiness Visual Analog Scale: A Simple Way to Predict Post-Stroke Smoking Behavior (2015)
    MDPI Publishing
    Details
    Publikationsdatum: 2015-08-14
    Beschreibung: Background and Purpose: The aim of the present study was to assess a relationship between readiness to quit and post-stroke smoking behavior. Methods: Eighty-six active smokers with first-ever ischemic stroke were recruited in a tertiary-care stroke unit. The question “Are you ready to quit smoking within the next month?” with yes/no responses and the 10-cm readiness visual analog scale (VAS) was administered during the anti-smoking intervention. Smoking status was verified at the 3- and 12-month follow-up. Results: The readiness VAS score at hospitalization was significantly lower in patients classified as smokers as compared to patients classified as non-smokers. The readiness score 〈5 cm was a significant predictor of smoking at the 3-month (OR, 7.3) and 12-month follow-up (OR, 4.9). Conclusions: The present results suggest that the readiness VAS can be used as a simple and inexpensive instrument for early identification of patients who continue to smoke after stroke.
    Print ISSN: 1661-7827
    Digitale ISSN: 1660-4601
    Thema: Energietechnik , Medizin
    Publiziert von MDPI Publishing
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
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    Materials, Vol. 8, Pages 5250-5264: Dislocation-Governed Plastic Deformation and Fracture Toughness of Nanotwinned Magnesium (2015)
    MDPI Publishing
    In: Materials
    Details
    Publikationsdatum: 2015-08-14
    Beschreibung: In this work, the plastic deformation mechanisms responsible for mechanical properties and fracture toughness in  nanotwinned (NT) magnesium is studied by molecular dynamics (MD) simulation. The influence of twin boundary (TBs) spacing and crack position on deformation behaviors are investigated. The microstructure evolution at the crack tip are not exactly the same for the left edge crack (LEC) and the right edge crack (REC) models according to calculations of the energy release rate for dislocation nucleation at the crack tip. The LEC growth initiates in a ductile pattern and then turns into a brittle cleavage. In the REC model, the atomic decohesion occurs at the crack tip to create a new free surface which directly induces a brittle cleavage. A ductile to brittle transition is observed which mainly depends on the competition between dislocation motion and crack growth. This competition mechanism is found to be correlated with the TB spacing. The critical values are 10 nm and 13.5 nm for this transition in LEC and REC models, respectively. Essentially, the dislocation densities affected by the TB spacing play a crucial role in the ductile to brittle transition.
    Digitale ISSN: 1996-1944
    Thema: Maschinenbau
    Publiziert von MDPI Publishing
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
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    Materials, Vol. 8, Pages 5265-5275: Plant Growth Absorption Spectrum Mimicking Light Sources (2015)
    MDPI Publishing
    In: Materials
    Details
    Publikationsdatum: 2015-08-14
    Beschreibung: Plant factories have attracted increasing attention because they can produce fresh fruits and vegetables free from pesticides in all weather. However, the emission spectra from current light sources significantly mismatch the spectra absorbed by plants. We demonstrate a concept of using multiple broad-band as well as narrow-band solid-state lighting technologies to design plant-growth light sources. Take an organic light-emitting diode (OLED), for example; the resulting light source shows an 84% resemblance with the photosynthetic action spectrum as a twin-peak blue dye and a diffused mono-peak red dye are employed. This OLED can also show a greater than 90% resemblance as an additional deeper red emitter is added. For a typical LED, the resemblance can be improved to 91% if two additional blue and red LEDs are incorporated. The approach may facilitate either an ideal use of the energy applied for plant growth and/or the design of better light sources for growing different plants.
    Digitale ISSN: 1996-1944
    Thema: Maschinenbau
    Publiziert von MDPI Publishing
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
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    Relative Risk of Acute Myocardial Infarction in People with Schizophrenia and Bipolar Disorder: A Population-Based Cohort Study (2015)
    Public Library of Science (PLoS)
    In: PLoS ONE
    Details
    Publikationsdatum: 2015-08-14
    Beschreibung: by Shu-I Wu, Su-Chiu Chen, Shen-Ing Liu, Fang-Ju Sun, Jimmy J. M. Juang, Hsin-Chien Lee, Kai-Liang Kao, Michael E. Dewey, Martin Prince, Robert Stewart Objective Despite high mortality associated with serious mental illness, risk of acute myocardial infarction (AMI) remains unclear, especially for patients with bipolar disorder. The main objective was to investigate the relative risk of AMI associated with schizophrenia and bipolar disorders in a national sample. Method Using nationwide administrative data, an 11-year historic cohort study was assembled, comprised of cases aged 18 and above who had received a diagnosis of schizophrenia or bipolar disorder, compared to a random sample of all other adults excluding those with diagnoses of serious mental illness. Incident AMI as a primary diagnosis was ascertained. Hazard ratios stratified by age and gender were calculated and Cox regression models were used to adjust for other covariates. Results A total of 70,225 people with schizophrenia or bipolar disorder and 207,592 people without serious mental illness were compared. Hazard ratios in men adjusted for age, income and urbanization were 1.15 (95% CI 1.01~1.32) for schizophrenia and 1.37 (1.08~1.73)for bipolar disorder, and in women, 1.85 (1.58~2.18) and 1.88(1.47~2.41) respectively. Further adjustment for treated hypertension, diabetes and hyperlipidaemia attenuated the hazard ratio for men with schizophrenia but not the other comparison groups. Hazard ratios were significantly stronger in women than men and were stronger in younger compared to older age groups for both disorders; however, gender modification was only significant in people with schizophrenia, and age modification only significant in people with bipolar disorder. Conclusions In this large national sample, schizophrenia and bipolar disorder were associated with raised risk of AMI in women and in the younger age groups although showed differences in potential confounding and modifying factors.
    Digitale ISSN: 1932-6203
    Thema: Medizin , Allgemeine Naturwissenschaft
    Publiziert von Public Library of Science (PLoS)
    Standort Signatur Erwartet Verfügbarkeit
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