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  • Springer  (45,369)
  • Oxford University Press  (9,203)
  • American Geophysical Union  (5,646)
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  • Annual Reviews
  • Blackwell Publishing Ltd
  • Periodicals Archive Online (PAO)
  • 2020-2024  (89)
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  • 2005-2009  (65,800)
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  • 2020-2024  (89)
  • 2020-2023
  • 2005-2009  (65,800)
  • 1990-1994
  • 1980-1984
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  • 1
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    Praktische Krankenhaushygiene und Umweltschutz (2006)
    Springer
    Details
    Pages: Online-Ressource (XII, 543 Seiten)
    Edition: 3. Aufl.
    ISBN: 9783540345251
    URL: https://doi.org/10.1007/3-540-34525-6
    Language: German
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  • 2
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    Towards a Vigilant Society (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-11
    Description: Towards a Vigilant Society sheds light on the emergence of a new society of vigilance, in particular the actions of anti-migrant groups around Dover and Calais. Based on field research on both sides of the channel, it studies the dynamics of these groups – midway between a social movement and vigilantism – at these two key points in the international migration route between the European Union and the United Kingdom. In recent years, a series of anti-migrant groups have been mobilising on both sides of the Channel to counter migrations. Their actions range from demonstrations, to violence against migrants. And by staging their actions on social media, which is an extraordinary sounding board, these groups can build an online community and a mass audience, influencing public opinion and even the migration policies of states.
    Keywords: Vigilantism Citizen participation in policing Securitisation Social reaction to migration Anti-migrant groups Far-right social movements Calais Dover Neighbourhood watches ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFH Migration, immigration and emigration ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PB Relating to peoples: ethnic groups, indigenous peoples, cultures and other groupings of people::5PBC Relating to migrant groups / diaspora communities or peoples ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFG Refugees and political asylum
    Language: English
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  • 3
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    City of Equals (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-06
    Description: When we think about equality in the city, we are very likely to think first of the wide and growing divide between rich and poor, in material terms. Yet when we think more about a 'city of equals' it becomes apparent that how people feel treated by the city and those around them, and whether they can live according to their values, are much more central. Accordingly, combining their own reflections, a multi-disciplinary literature review, and, distinctively, more than 180 interviews in 10 cities in 6 countries, Wolff and de Shalit have derived an account of a city of equals based on the idea that it should give each of its city-zens a secure sense of place or belonging. Four underlying values structure this account. First, access to the goods and services of the city should not be based purely on the market. Second, each person should be able to live a life they find meaningful. Third, there should be diversity and wide social mixing. Fourth, there should be 'non-deferential inclusion': each person should be able to get access to what they are entitled to without being treated as less worthy than others. They should be able to enjoy their rights without bowing and scraping, waiting longer than others, or going through special bureaucratic hurdles. In sum, in a city of equals each person is proud of their city and has the (justified) feeling that their city is proud of (people like) them.
    Keywords: cities, equality, inequality, relational equality, equality in the city, inclusion, diversity, social mixing, public reflective equilibrium, urban political philosophy ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography
    Language: English
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  • 4
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    The Ethics of Surveillance in Times of Emergency (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-08
    Description: The Covid-19 pandemic is arguably the first international emergency of the twenty-first century. In order to respond to this emergency, countries and governments around the world were forced to engage in a range of actions and policies that would not otherwise have been permitted. Looking in particular at the use of surveillance technologies, this book examines the challenge of ethics in emergencies. What can states do to keep their populations safe, what can citizens expect of their governments, and when are those government actions unjustified? By looking at the use of surveillance in times of emergency, this book explores ethical, philosophical, political, and social concepts, challenges them, and offers a set of views on where those concepts may evolve into the future. As a global population, we will be faced with emergencies, and it is possible that these will also be global in their impact. The ethics of surveillance in times of emergency is both of its time, and ongoing; we must learn our lessons from the last emergency, to be prepared for the next ones.
    Keywords: applied ethics, surveillance, emergency ethics, pandemics, public health ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine
    Language: English
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  • 5
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    What Is Structural Injustice? (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-04
    Description: What is Structural Injustice? is the first edited collection to bring together the voices of leading structural injustice scholars from politics, philosophy and law to explore the concept of structural injustice which has now become a central feature of all three disciplines and is considered by many to be a ‘field of study.’ The volume features specially selected original and essential works on structural injustice. The volume provides a range of disciplinary, ontological and epistemological perspectives on what structural injustice is and includes feminist and post-colonial theories to interrogate how structural injustice exacerbates and reproduces existing inequalities and relations of power. This book aims to become a touchstone text for those interested in the different ways we can understand structural injustice, how it manifests, how it relates to other forms of injustice, who is responsible for its redress and the different ways we might go about it. This book will appeal to a wide audience of students, both undergraduate and postgraduate, as well as the general academic population, experts on structural injustice, interested practitioners in politics and members of the public.
    Keywords: " Structural injustice, politics, philosophy, law, ontology, epistemology, feminism, power, historical injustice. " ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 6
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    Just Prospering? Plato and the Sophistic Debate about Justice (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-11
    Description: This book argues that Plato’s Republic must be understood as developing out of a 5th Century sophistic debate. In Part One the author presents a new analysis of the sophists and their extant texts addressing the important topics of justice and its value. This part shows that already in the 5th Century there was a robust debate about whether the just or unjust life was better for the self-interested individual, and that multiple sophistic authors made inventive and philosophically sophisticated arguments on both sides of this debate. The Moral Cynics argues that the intelligent individual was better off being unjust, whereas the Friends of Justice defended the idea that the just life was better for human beings. Part Two argues that Plato was very much aware of this debate and that in a number of dialogues—but most importantly in Republic—he engaged with this debate. The immoralist challenge that Glaucon and Adeimantus pose to Socrates early in Republic draws from the arguments of the 5th Century Moral Cynics and moreover identifies problems with the arguments of the 5th Century Friends of Justice. By having Socrates make an argument that overcomes the theoretical weaknesses of the earlier Friends of Justice, Plato is able to pose a new defence of justice that is more effective at responding to the Moral Cynics. The book’s analysis of Republic suggests new readings for certain important passages, such as the division of goods.
    Keywords: Justice Prospering [εὐδαιμονία] Plato The Sophists The History of Moral and Political Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHA Ancient Greek and Roman philosophy ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAB Methods, theory and philosophy of law ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy ; thema EDItEUR::3 Time period qualifiers::3C BCE period – Protohistory ; thema EDItEUR::1 Place qualifiers::1Q Other geographical groupings: Oceans and seas, historical, political etc::1QB Historical states, empires, territories and regions::1QBA Ancient World::1QBAG Ancient Greece
    Language: English
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  • 7
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    Landscape, Religion, and the Supernatural (2024)
    Oxford University Press
    Details
    Publication Date: 2024-03-19
    Description: Landscape, Religion, and the Supernatural presents a summa of current and classic theorizing on religion and the supernatural in relationship to the land and develops this theorizing further by confronting it with a rich set of folkloristic and historical data. Focusing on the themes of “time and memory,” “repeating patterns,” “identity formation,” “morality,” “labor,” “playfulness and adventure,” “power and subversion,” “sound,” “emotions,” “coping with contingency,” “home and unhomeliness,” and “nature and environment,” the book engages with a broad range of theoretical concepts and approaches from the interdisciplinary field of landscape theory and the study of religions. It brings this theorizing into dialogue with the rich culture of local storytelling and landscape-related traditional beliefs of the Strandir district of the Icelandic Westfjords. In this rural region, landscape-related traditions have been collected since the early nineteenth century and continue to be important to this day. Confronting this rich heritage with the insights of landscape theory both in and beyond the study of religions allows important new contributions to theorizing landscape and religion, especially when it comes to considering the perspectives on landscape held by rural populations rather than the urban upper classes that have stood in the focus of research to date. The example of the Icelandic Westfjords shows the extreme richness of religious and supernatural approaches to the landscape that can be developed in rural communities, and how they are significantly and characteristically different from the urban perspectives of literature and the arts.
    Keywords: landscape, religion, supernatural, space, place, folklore, folk belief, Iceland ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology ; bic Book Industry Communication::H Humanities::HR Religion & beliefs ; bic Book Industry Communication::H Humanities::HB History::HBT History: specific events & topics::HBTP Historical geography ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSL Ethnic studies::JFSL9 Indigenous peoples
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  • 8
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    Politics and the Urban Frontier (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-05
    Description: Despite the rise of global technocratic ideals of city-making, cities around the world are not merging into indistinguishable duplicates of one another. In fact, as the world urbanizes, urban formations remain diverse in their socio-economic and spatial characteristics, with varying potential to foster economic development and social justice. This book argues that these differences are primarily rooted in politics, and if we continue to view cities as economic and technological projects to be managed rather than terrains of political bargaining and contestation, the quest for better urban futures is doomed to fail. Dominant critical approaches to urban development tend to explain difference with reference to the variegated impacts of neoliberal regulatory institutions. This, however, neglects the multiple ways in which the wider politics of capital accumulation and distribution drive divergent forms of transformation in different urban places. In order to unpack the politics that shapes differential urban development, this book focuses on East Africa as the global urban frontier: the least urbanized but fastest urbanizing region in the world. Drawing on a decade of research spanning three case-study countries (Ethiopia, Rwanda, and Uganda), Politics and the Urban Frontier provides the first sustained, book-length comparative analysis of urban development trajectories in Eastern Africa and the political dynamics underpinning them. Through a focus on infrastructure investment, urban propertyscapes, street-level trading economies, and urban political protest, it offers a multi-scalar, historically grounded, and interdisciplinary analysis of the urban transformations unfolding in the world’s most dynamic crucible of urban change.
    Keywords: urban development, East Africa, comparative urban politics, late urbanization, infrastructure, planning, protest, Ethiopia, Rwanda, Uganda ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCM Development economics and emerging economies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVS Regional / urban economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCP Political economy ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCG Economic growth ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGC Human geography::RGCM Economic geography
    Language: English
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  • 9
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    Social Democratic Capitalism (2024)
    Oxford University Press
    Details
    Publication Date: 2024-03-29
    Description: What configuration of institutions and policies is most conducive to human flourishing? The historical and comparative evidence suggests that the answer is social democratic capitalism — a democratic political system, a capitalist economy, good elementary and secondary schooling, a big welfare state, pro-employment public services, and moderate regulation of product and labor markets. Lane Kenworthy shows that this system improves living standards for the least well-off, enhances economic security, and boosts equality of opportunity. And it does so without sacrificing other things we want in a good society, from liberty to economic growth to health and happiness. Its chief practitioners have been the Nordic nations. The Nordics have gone farther than other rich democratic countries in coupling a big welfare state with public services that promote high employment and modest product- and labor-market regulations. Many believe this system isn’t transferable beyond Scandinavia, but Kenworthy shows that social democratic capitalism and its successes can be replicated in other affluent nations, including the United States. Today, the U.S. lags behind other countries in economic security, opportunity, and shared prosperity. If the U.S. expanded existing social programs and added some additional ones, many Americans would have better lives. Kenworthy argues that, despite formidable political obstacles, the U.S. is likely to move toward social democratic capitalism in coming decades. As a country gets richer, he explains, it becomes more willing to spend more in order to safeguard against risk and enhance fairness. He lays out a detailed policy agenda that could alleviate many of America’s problems.
    Keywords: Social democratic capitalism, American politics, comparative politics, Western European politics, democracy, capitalism, welfare state, economic reform, regulation, economic equality ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSL Geopolitics
    Language: English
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  • 10
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    Languages and Communities in the Late-Roman and Post-Imperial Western Provinces (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-02
    Description: Languages are central to the creation and expression of identities and cultures, as well as to life itself, yet the linguistic variegation of the later-Roman and post-imperial period in the Roman West is remarkably understudied. A deeper understanding of this important issue is crucial to any reconstruction of the broader story of linguistic continuity and change in Europe and the Mediterranean, as well as to the history of the communities who wrote, read, and spoke Latin and other languages. In spite of intensive study of culture and ethnic identity in late antiquity, language has often been neglected, a neglect encouraged by the disciplinary boundaries between linguists and historians, Romanists, and medievalists. There is no single volume that sets out the main developments, key features, and debates of the later-Roman and post-imperial linguistic environment. The linguistic landscapes of the late-Roman and post-imperial West are difficult to uncover and describe, while attempts to speak across disciplinary divides are challenging. The contributors have tackled this subject by offering detailed coverage of the Iberian Peninsula, North Africa, Gaul, the Germanies, Britain, and Ireland. This volume, the third in the LatinNow series, helps readers to understand better the embeddedness, or not, of Latin, at different social levels and across provinces, to consider (socio)linguistic variegation, bilingualism and multilingualism, and attitudes towards languages, and to confront the complex role of language in the communities, identities, and cultures of the later and post-imperial Roman West.
    Keywords: early middle ages, Gaul, the Germanies, Iberian Peninsula, later Roman world, Latin, local language, sociolinguistics, western provinces ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics
    Language: English
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  • 11
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    Gauge theory of elementary particle physics (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-11
    Description: Students of particle physics often find it difficult to locate resources to learn calculational techniques. Intermediate steps are not usually given in the research literature. To a certain extent, this is also the case even in some of the textbooks. In this book of worked problems we have made an effort to provide enough details so that a student starting in the field will understand the solution in each case. Our hope is that with this step-by-step guidance, students (after first attempting the solution themselves) can develop their skill, and confidence in their ability, to work out particle theory problems.
    Keywords: nuclear physics, mathematical and statistical physics, pure mathematics ; thema EDItEUR::P Mathematics and Science::PH Physics::PHS Statistical physics ; thema EDItEUR::P Mathematics and Science::PH Physics::PHF Materials / States of matter ; thema EDItEUR::P Mathematics and Science::PH Physics::PHF Materials / States of matter::PHFC Condensed matter physics (liquid state and solid state physics) ; thema EDItEUR::P Mathematics and Science::PH Physics::PHQ Quantum physics (quantum mechanics and quantum field theory) ; thema EDItEUR::P Mathematics and Science::PH Physics::PHK Electricity, electromagnetism and magnetism ; thema EDItEUR::P Mathematics and Science::PH Physics::PHU Mathematical physics
    Language: English
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  • 12
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    Babies in Groups (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-07
    Description: Babies in Groups examines the consequences for science, for childcare policy, and for adult psychotherapy, of findings that young babies capably enjoy participating in groups. The authors’ research on preverbal infants’ capacities for group-communication in all-baby trios and quartets opens up new ways of imagining human development as fundamentally group-based. Babies in Groups highlights the changes a group-based vision of infancy brings to early child education and care by documenting the transformative consequences of introducing group-based practices into a high-quality childcare service in rural Australia. The book also examines the ways in which the belief that one-to-one infant-adult ‘attachments’ grounds human development unnecessarily narrows understanding of human potential, and slants scientific research. This examination culminates by showing how ignoring group contexts in many clinical traditions can distort descriptions of what happens in therapy, producing such unintended consequences as ‘mother-blaming’ for the future problems an infant may experience as she or he grows up.
    Keywords: attachment theory; childcare; childcare policy; cultural criticism; dyadic vision; early education; group psychology; human evolution; intersubjectivity; psychotherapy. ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMC Child, developmental and lifespan psychology ; thema EDItEUR::J Society and Social Sciences::JN Education::JNL Schools and pre-schools::JNLA Pre-school and kindergarten ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMH Social, group or collective psychology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies
    Language: English
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  • 13
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    The Politics of Revenue Bargaining in Africa (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-03
    Description: This book examines the politics of revenue bargaining in Africa in a time when attention to domestic revenue mobilisation has expanded immensely. Measures to increase taxes and other revenues can -but do not always- lead to a process of bargaining, where revenue providers negotiate for some kind of a return. This book offers in-depth analyses of micro-instances of revenue bargaining across five African countries: Mozambique, Senegal, Tanzania, Togo, and Uganda. All case studies draw on a common theoretical framework combining the fiscal contract theory with the political settlement approach, which enables a systematic exploration into what triggers revenue bargaining; how these processes unfold; and finally, if and when they reach an agreement (whether a fiscal contract or not). From the empirically rich case narratives emerges a story of how power and initial bargaining position influence not only whether bargaining emerges in the first place, but also the processes and their outcomes. Less resourceful taxpayers are in a more difficult position to raise their voice, but in some cases even these groups manage to ally with other civil society groups to protest against tax reforms they perceive as unfair. Indirect taxes such as VAT often trigger protests, and so do sudden changes in tax practices. Revenue providers rarely call for improved services in return for paying tax, which would be expected to nurture the foundation for a fiscal social contract. Instead, revenue providers are more likely to negotiate for tax reductions, implying that governments’ effort to increase revenue is impeded. We do find many instances of state-society reciprocity when ruling elites try to be responsive to revenue providers’ demands. Hence, this book gives insight into the nature and dynamics not only of revenue bargaining but of policy-making in general as well as the implications hereof for state-society reciprocity in Africa.
    Keywords: Revenue bargaining; fiscal contract; political settlement; Africa; taxation; state-society relations; political economy; domestic revenue mobilisation; reciprocity; comparative politics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCM Development economics and emerging economies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCP Political economy ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies ; thema EDItEUR::1 Place qualifiers::1H Africa
    Language: English
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  • 14
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    The Practical Playbook III (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-07
    Description: Every day, two or three women die because of pregnancy or childbirth. Nearly 80% of these deaths are preventable. These outcomes disproportionately impact racialized populations, including Black and Indigenous women, who are two to three times more likely to die. The Practical Playbook III: Working Together to Improve Maternal Health is a guide for maternal health stakeholders (like researchers, community activists, providers, and advocates) offering practical tools and strategies to address inequities in maternal health services and outcomes. With contributions from more than 150 authors, each chapter offers a different strategy that stakeholders can apply to improve maternal health in their community. The 50 chapters are divided into six main sections: Section I, Introduction; Section II, Collaborations; Section III, Equity; Section IV, Data; Section V, Innovations; and Section VI, Systems and Scalability. The chapters focus on ways to save mothers by centering equity, collaborating with people with lived experience, building better data systems, piloting and expanding innovations, and leveraging resources to scale and sustain what works. Throughout the book, readers encounter stories from women and birthing people that bring the problems and solutions into better focus. The editors are committed to continuing to share information about initiatives that are moving the needle through our online platforms.
    Keywords: Maternal Mortality, Maternal Morbidity Racial Disparities, maternal health equity, maternal health stakeholders, playbook, Maternal Health Data, Collaboration, Innovation, Sustainability ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKC Gynaecology and obstetrics ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics
    Language: English
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  • 15
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    Comparing the Worth of the While in Fiji and Finland (2024)
    Oxford University Press
    Details
    Publication Date: 2024-03-19
    Description: Comparing the Worth of the While in Fiji and Finland presents comparative case studies of clock time from Fiji and Finland in order to ask what other values is time capable of expressing besides monetary worth – what “else” can time be besides money? Time is a highly particular vehicle for different considerations of what is good or important, but it is also one which is deployed at different settings with surprisingly little consideration for the specificity of this particular a value form. This book looks into the different ways in which time is deployed in value projects in Fiji and Finland, not just to point out the various possible ways of allocating value to time, but to show that European clock-time, just like its Oceanic counterparts, requires a great deal of conceptual work to make it serve as vehicle of valuation. The cases analysed in the book range from considerations of rank and conspicuous leisure in Fiji to Finnish timebanking, taxation, and university auditing.
    Keywords: Fiji, Finland, time, value, anthropology ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology::JHMC Social & cultural anthropology, ethnography ; bic Book Industry Communication::P Mathematics & science::PG Astronomy, space & time::PGZ Time (chronology), time systems & standards ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology
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  • 16
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    The Impact of the Inter-American Human Rights System (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-07
    Description: The Inter-American Human Rights System (IAHRS) fosters structural transformations throughout the Americas. This collection of analyses builds upon the studies on Ius Constitutionale Commune en América Latina and Latin American transformative constitutionalism to map out both the ground-level human rights impact of the IAHRS and the institutional characteristics that have enabled such fundamental changes in social reality. The volume starts with essays framing the concept and context of IAHRS impact. Then it navigates thematic analyses on specific rights and types of violations that are front and center to the protection of human rights in Latin America. The concluding essays explore whether and how it is possible to optimize the actions of the Inter-American System, indicating possible paths to increase positive human rights impact. The editors contend that the IAHRS victim-centric approach, community of practice, and openness to institutional reinvention have enabled it to create a virtuous cycle that catalyzes human rights in the Americas, furthering democracy and the Rule of Law throughout the continent.
    Keywords: Inter-American System, impact, human rights, Transformative Constitutionalism, Latin America ; thema EDItEUR::L Law::LB International law::LBB Public international law::LBBZ Public international law: criminal law ; thema EDItEUR::1 Place qualifiers::1K The Americas::1KL Latin America – Mexico, Central America, South America ; thema EDItEUR::L Law::LB International law::LBB Public international law::LBBR Public international law: human rights
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  • 17
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    The Nature of Physical Computation (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-14
    Description: Computing systems are everywhere today. Even the brain is thought to be a sort of computing system. But what does it mean to say that a given organ or system computes? What is it about laptops, smartphones, and nervous systems that they are deemed to compute, and why does it seldom occur to us to describe stomachs, hurricanes, rocks, or chairs that way? The book provides an extended argument for the semantic view of computation, which states that semantic properties are involved in the nature of computing systems. Laptops, smartphones, and nervous systems compute because they are accompanied by representations. Stomachs, hurricanes, and rocks, for instance, which do not have semantic properties, do not compute. The first part of the book argues that the linkage between the mathematical theory of computability and the notion of physical computation is weak. Theoretical notions such as algorithms, effective procedure, program, and automaton play only a minor role in identifying physical computation. The second part of the book reviews three influential accounts of physical computation and argues that while none of these accounts is satisfactory, each of them highlights certain key features of physical computation. The final part of the book develops and argues for a semantic account of physical computation and offers a characterization of computational explanations.
    Keywords: Metaphysics; Philosophy of Mathematics & Logic; Philosophy of Computational Science; Philosophy of Mathematics & Logic ; thema EDItEUR::U Computing and Information Technology::UY Computer science ; thema EDItEUR::U Computing and Information Technology::UY Computer science
    Language: English
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    Cultural Change in Post-Migrant Societies (2024)
    Springer
    Details
    Publication Date: 2024-01-10
    Description: The volume offers insights into new theoretical approaches that should make it possible to analyse cultural change through migration. It focuses on concrete activities in local contexts and their significance for national narratives. Finally, it presents newer approaches in migration studies that use artistic methods and work with cultural institutions to drive cultural change.
    Description: Der Band bietet Einblick in neue theoretische Ansätze, die ermöglichen sollen, kulturellen Wandel durch Migration zu analysieren. Er richtet den Blick auf konkrete Aktivitäten in lokalen Kontexten und deren Bedeutung für nationale Narrative. Abschließend präsentiert er neuere Ansätze in der Migrationsforschung, die sich künstlerischer Methoden bedienen und mit kulturellen Institutionen zusammenarbeiten, um kulturelle Veränderung voranzutreiben.
    Keywords: Migration; Postmigration; kultureller Wandel; Kunst; Kultur ; ÖFOS 2012 -- SOZIALWISSENSCHAFTEN (5) -- Soziologie (504) -- Soziologie (5040) -- Migrationsforschung (504021) ; ÖFOS 2012 -- GEISTESWISSENSCHAFTEN (6) -- Andere Geisteswissenschaften (605) -- Andere Geisteswissenschaften (6050) -- Kulturwissenschaft (605004) ; Migration; postmigration; cultural change; art; culture ; ÖFOS 2012 -- SOCIAL SCIENCES (5) -- Sociology (504) -- Sociology (5040) -- Migration research (504021) ; ÖFOS 2012 -- HUMANITIES (6) -- Other Humanities (605) -- Other Humanities (6050) -- Cultural studies (605004)
    Language: English
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    Social Factors in the Latinization of the Roman West (2024)
    Oxford University Press
    Details
    Publication Date: 2024-05-11
    Description: Latinization is a strangely overlooked topic. Historians have noted it has been ‘taken for granted’ and viewed as an unremarkable by-product of ‘Romanization’, despite its central importance for understanding the Roman provincial world, its life and languages. This volume aims to fill the gap in our scholarship, along with its sister volumes, Latinization, Local Languages and Literacies in the Roman West and Languages and Communities in the Late-Roman and Post-Imperial Western Provinces, all outputs of the European Research Council-funded LatinNow project. Experts have been selected to create a multidisciplinary volume with a thematic approach to the vast subject, tackling administration, army, economy, law, mobility, religion (local and imperial religions and Christianity), social status, and urbanism. They situate the phenomena of Latinization, literacy, bi-, and multilingualism within local and broader social developments and draw together materials and arguments that have not before been coordinated in a single volume. The result is a comprehensive guide to the theme, which also offers original and more experimental work. The sociolinguistic, historical, and archaeological contributions reinforce, expand, and sometimes challenge our vision of Latinization and lay the foundations for future explorations.
    Keywords: army, economy, education, law, Latinization, mobility, religion, Roman western provinces, sociolinguistics, status, urbanism ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics
    Language: English
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    Responsibility and Healthcare (2024)
    Oxford University Press
    Details
    Publication Date: 2024-05-13
    Description: Questions of responsibility arise at all levels of health care. Most prominent has been the issue of patient responsibility. Some health conditions that risk death or serious harm are partly the result of lifestyle behaviours such as smoking, lack of exercise, or extreme sports. Are patients with such conditions responsible for them? If so, might healthcare providers, be they state-run systems or private entities, be justified in treating such patients differently? And if they are, which forms of differential treatment are justified? Responsibility isn’t just relevant for patients. Even when individuals affect their health through voluntary behaviour, other influences are also at work before, during, and after the patient’s interaction with the health care system. What are the responsibilities of individual clinicians and other medical professionals, when thinking about individual and public health? What about institutions such as governments or national health care services, or society as a whole? This collection brings together work by world-renowned experts in population ethics, distributive justice, philosophy of action, cognitive science, and medical ethics in order to push the debate forward by elucidating our understanding of these questions, their possible answers, and how they are related.
    Keywords: responsibility, health, health care, ethics, medical ethics ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bioethics ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNT Social law and Medical law::LNTJ Public health and safety law ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: English
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    Access to Power (2024)
    Oxford University Press
    Details
    Publication Date: 2024-03-29
    Description: Pakistan would desperately like to produce enough electricity, but it usually doesn’t. This is the rare issue on which government and private sector can unite, and it is the cause of suffering for rich and poor alike across the entirety of the country. Despite prioritization by successive governments, targeted reforms shaped by international development actors, and featuring prominently in Chinese Belt and Road Investments, the Pakistani power sector still stifles economic and social life across the country. This book explores state capacity in Pakistan by following the material infrastructure of electricity across the provinces and down into cities and homes. It argues that the national challenges of budgetary constraints and power shortages directly result from conscious strategic decisions that are integral to Pakistan’s infrastructural state. Electricity shortages are one of the many poor governance outcomes characteristic of low- and middle-income countries. Standard development thinking points to an absence of institutions in comparison with an idealized and distant other country, with governance reform programs formulated accordingly. However, an orientation toward what Pakistan is not takes us away from how it actually functions and to whose benefit. Electricity governance in Pakistan reinforces relations of power between provinces and the federal center, contributes to the marginalization of subordinate groups in the city, and orients citizens toward a patronage-based relationship with the state through encounters with street-level bureaucrats. Looking through the lens of the electrical power sector reveals how Pakistan works, and for whom.
    Keywords: state capacity, infrastructure, electricity, Pakistan, urban, ethnography, institutions, political economy, development, China–Pakistan Economic Corridor ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTP Development studies ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies
    Language: English
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    Would Democratic Socialism Be Better? (2024)
    Oxford University Press
    Details
    Publication Date: 2024-04-03
    Description: The case for a modern democratic humane socialism typically has two parts. The first is that capitalism is bad, at or least not very good. In reaching this conclusion, most have either analyzed a theoretical ideal-type of capitalism or used a single country, often the United States, as a stand-in for capitalism. To fully and fairly assess democratic socialism’s desirability, we need to compare it to the best version of capitalism that humans have devised: social democratic capitalism, or what is often called the Nordic model. Each chapter in this book examines one of the things that we should want in a good society, that contemporary democratic socialists typically say they want, and that socialism might, conceivably, improve our ability to achieve: an end to poverty in rich countries, an end to poverty everywhere, more jobs, decent jobs, faster economic growth, inclusive growth, more public goods and services, affordable healthcare for all, helpful finance, truly democratic politics, economic democracy, less economic inequality, gender and racial equality, more community, and a livable planet. The book offers a close look at the evidence about how capitalist economies have performed on these outcomes, with particular attention to the performance of social democratic capitalism. The second part of the case for democratic socialism is the notion that it would be an improvement. For each of these outcomes, the book considers what, if anything, we can conclude about whether democratic socialism would do better than social democratic capitalism.
    Keywords: capitalism, socialism, Nordic model, poverty, employment, democracy, equality, inclusion, community ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSL Geopolitics
    Language: English
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    Mental Imagery (2024)
    Oxford University Press
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    Publication Date: 2024-04-08
    Description: This book is about mental imagery and the important work it does in our mental life. It plays a crucial role in the vast majority of our perceptual episodes. It also helps us understand many of the most puzzling features of perception (like the way it is influenced in a top-down manner and the way different sense modalities interact). But mental imagery also plays a very important role in emotions, action execution, and even in our desires. In sum, there are very few mental phenomena that mental imagery doesn’t show up in—in some way or other. The hope is that if we understand what mental imagery is, how it works and how it is related to other mental phenomena, we can make real progress on a number of important questions about the mind. This book aims at an interdisciplinary audience. As it aims to combine philosophy, psychology, and neuroscience to understand mental imagery, I have not presupposed any prior knowledge in any of these disciplines. As a result, readers with no background in any of these disciplines can also follow the arguments.
    Keywords: mental imagery, imagination, perception, philosophy, psychology, neuroscience ; bic Book Industry Communication::H Humanities::HP Philosophy::HPM Philosophy of mind ; bic Book Industry Communication::H Humanities::HP Philosophy::HPN Philosophy: aesthetics ; bic Book Industry Communication::J Society & social sciences::JM Psychology::JMR Cognition & cognitive psychology::JMRP Perception ; bic Book Industry Communication::H Humanities::HP Philosophy ; bic Book Industry Communication::J Society & social sciences::JM Psychology::JMR Cognition & cognitive psychology ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTM Philosophy of mind ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTN Philosophy: aesthetics ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMR Cognition and cognitive psychology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    FLUID MECHANICAL ASPECTS OF THE GAS-LIFT TECHNIQUE (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 225-249 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The gas-lift technique comprises the injection of gas bubbles in vertical oil wells to increase production. It is based on a reduction of the tubing gravitational pressure gradient. Several fluid-flow phenomena influencing such vertical gas-liquid flows are discussed. These effects include the radial distribution of void fraction and of gas and liquid velocity, flow regime changes, and system stability problems. Associated consequences for gas-lift performance and related optimization approaches are also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.061505.093942
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    PASSIVE AND ACTIVE FLOW CONTROL BY SWIMMING FISHES AND MAMMALS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 193-224 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: What mechanisms of flow control do animals use to enhance hydrodynamic performance? Animals are capable of manipulating flow around the body and appendages both passively and actively. Passive mechanisms rely on structural and morphological components of the body (i.e., humpback whale tubercles, riblets). Active flow control mechanisms use appendage or body musculature to directly generate wake flow structures or stiffen fins against external hydrodynamic loads. Fish can actively control fin curvature, displacement, and area. The vortex wake shed by the tail differs between eel-like fishes and fishes with a discrete narrowing of the body in front of the tail, and three-dimensional effects may play a major role in determining wake structure in most fishes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092201
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    LONG NONLINEAR INTERNAL WAVES (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 395-425 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Over the past four decades, the combination of in situ and remote sensing observations has demonstrated that long nonlinear internal solitary-like waves are ubiquitous features of coastal oceans. The following provides an overview of the properties of steady internal solitary waves and the transient processes of wave generation and evolution, primarily from the point of view of weakly nonlinear theory, of which the Korteweg-de Vries equation is the most frequently used example. However, the oceanographically important processes of wave instability and breaking, generally inaccessible with these models, are also discussed. Furthermore, observations often show strongly nonlinear waves whose properties can only be explained with fully nonlinear models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092129
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    ELECTROKINETIC FLOW AND DISPERSION IN CAPILLARY ELECTROPHORESIS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 309-338 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Electrophoretic separation of a mixture of chemical species is a fundamental technique of great usefulness in biology, health care, and forensics. In capillary electrophoresis (which has evolved from its predecessor, slab-gel electrophoresis), the sample migrates through a single microcapillary instead of through the network of pores in a gel. A fundamental design problem is to minimize dispersion in the separation direction. Molecular diffusion is inevitable and sets a theoretical limit on the best separation that can be achieved. But in practice, there are a number of effects arising out of the interplay between fluid flow, chemistry, thermal effects, and electric fields that result in enhanced dispersion. This paper reviews the subject of fluid flow in such capillary microchannels and examines the various causes of enhanced dispersion that limit the efficiency of separation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092053
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    AERODYNAMICS OF RACE CARS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 27-63 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Race car performance depends on elements such as the engine, tires, suspension, road, aerodynamics, and of course the driver. In recent years, however, vehicle aerodynamics gained increased attention, mainly due to the utilization of the negative lift (downforce) principle, yielding several important performance improvements. This review briefly explains the significance of the aerodynamic downforce and how it improves race car performance. After this short introduction various methods to generate downforce such as inverted wings, diffusers, and vortex generators are discussed. Due to the complex geometry of these vehicles, the aerodynamic interaction between the various body components is significant, resulting in vortex flows and lifting surface shapes unlike traditional airplane wings. Typical design tools such as wind tunnel testing, computational fluid dynamics, and track testing, and their relevance to race car development, are discussed as well. In spite of the tremendous progress of these design tools (due to better instrumentation, communication, and computational power), the fluid dynamic phenomenon is still highly nonlinear, and predicting the effect of a particular modification is not always trouble free. Several examples covering a wide range of vehicle shapes (e.g., from stock cars to open-wheel race cars) are presented to demonstrate this nonlinear nature of the flow field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092016
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    LARGE-EDDY SIMULATION OF TURBULENT COMBUSTION (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 453-482 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Large-eddy simulation (LES) of turbulent combustion is a relatively new research field. Much research has been carried out over the past years, but to realize the full predictive potential of combustion LES, many fundamental questions still have to be addressed, and common practices of LES of nonreacting flows revisited. The focus of the present review is to highlight the fundamental differences between Reynolds-averaged Navier-Stokes (RANS) and LES combustion models for nonpremixed and premixed turbulent combustion, to identify some of the open questions and modeling issues for LES, and to provide future perspectives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092133
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    BIOFLUIDMECHANICS OF REPRODUCTION (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 371-394 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Mammalian fertilization requires the coordinated activity of motile spermatozoa, muscular contractions of the uterus and oviduct, as well as ciliary beating. These elastic structures generate forces that drive fluid motion, but their configurations are, in turn, determined by the fluid dynamics. We review the basic fluid mechanical aspects of reproduction, including flagellar/ciliary beating and peristalsis. We report on recent biological studies that have shed light on the relative importance of the mechanical ingredients of reproduction. In particular, we examine sperm motility in the reproductive tract, ovum pickup and transport in the oviduct, as well as sperm-egg interactions. We review recent advances in understanding the internal mechanics of cilia and flagella, flagellar surface interaction, sperm motility in complex fluids, and the role of fluid dynamics in embryo transfer. We outline promising computational fluid dynamics frameworks that may be used to investigate these complex, fluid-structure interactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.37.061903.175725
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    COMPUTATIONAL PREDICTION OF FLOW-GENERATED SOUND (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 483-512 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: This article provides a critical review of computational techniques for flow-noise prediction and the underlying theories. Hybrid approaches, in which the turbulent noise source field is computed and/or modeled separately from the far-field calculation, are afforded particular attention. Numerical methods and modern flow simulation techniques are discussed in terms of their suitability and accuracy for flow-noise calculations. Other topics highlighted include some important formulation and computational issues in the application of aeroacoustic theories, generalized acoustic analogies with better accounts of flow-sound interaction, and recent computational investigations of noise-control strategies. The review ends with an analysis of major challenges and key areas for improvement in order to advance the state of the art of computational aeroacoustics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092036
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    CRITICAL HYPERSONIC AEROTHERMODYNAMIC PHENOMENA * (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 129-157 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The challenges in understanding hypersonic flight are discussed and critical hypersonic aerothermodynamics issues are reviewed. The ability of current analytical methods, numerical methods, ground testing capabilities, and flight testing approaches to predict hypersonic flow are evaluated. The areas where aerothermodynamic shortcomings restrict our ability to design and analyze hypersonic vehicles are discussed, and prospects for future capabilities are reviewed. Considerable work still needs to be done before our understanding of hypersonic flow will allow for the accurate prediction of vehicle flight characteristics throughout the flight envelope from launch to orbital insertion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092041
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    MODELING SHAPES AND DYNAMICS OF CONFINED BUBBLES (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 277-307 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: We review mathematical models of confined bubbles, emphasizing physical mechanisms as expressed in simple geometries. Molecular interactions between liquid, gas, and the confining solid are all important and are described through the disjoining pressure concept. Methods for finding static shapes are considered. The static solution is a springboard for discussing pressure-driven and surface-tension-driven flows, both of which involve viscous effects and macroscopic films entrained near apparent contact lines. We next discuss vapor bubbles produced by thermal effects. Vaporization localized near contact lines and condensation distributed in colder parts of the interface lead to steady vapor bubbles. Their size is determined through global constraints. Unsteady vapor bubbles are discussed and we end with thoughts on open problems.
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    DROP IMPACT DYNAMICS: Splashing, Spreading, Receding, BouncingĐ?† (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 159-192 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The review deals with drop impacts on thin liquid layers and dry surfaces. The impacts resulting in crown formation are referred to as splashing. Crowns and their propagation are discussed in detail, as well as some additional kindred, albeit nonsplashing, phenomena like drop spreading and deposition, receding (recoil), jetting, fingering, and rebound. The review begins with an explanation of various practical motivations feeding the interest in the fascinating phenomena of drop impact, and the above-mentioned topics are then considered in their experimental, theoretical, and computational aspects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092144
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    DYNAMICS AND CONTROL OF HIGH-REYNOLDS-NUMBER FLOW OVER OPEN CAVITIES (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 251-276 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: We review recent advances in understanding, modeling, and controlling oscillations in the flow past a cavity. The fundamental mechanisms underlying cavity flow oscillations have been known for at least 40 years, but suppressing these oscillations in a reliable and robust way is still a challenge today. Interest in controlling the flow past a cavity is motivated by aerospace applications, but in addition, cavity flows provide an attractive canonical problem for exploring general flow control techniques. The focus is on recent advances in modeling these flows, and in controlling them, using both open-loop and closed-loop techniques. A relatively new perspective is that cavity oscillations may not always be self-sustained, but under some flow conditions may be lightly damped resonances, sustained by external disturbances such as boundary layer turbulence. Areas in which our understanding is incomplete, and which deserve further study, are discussed, in particular the effects of high-frequency open-loop forcing, fundamental limitations of feedback control for a given configuration of sensors and actuators, and the development of a feedback design methodology that respects the limited range of validity of the available dynamical models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092057
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    PREMELTING DYNAMICS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 427-452 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: When the free surfaces of most solids approach their bulk melting temperatures from below, the molecular structure of the material gives way to a disordered structure with some attributes of both the solid and liquid phases. When the temperature is sufficiently close to that of bulk transition, the surface melts and literally flows as a viscous fluid. This phenomenon, called interfacial premelting, lies at the heart of the microscopic theory of melting of solid matter, and captures the interest of condensed matter physicists and physical chemists alike. The process is ubiquitous and responsible for a wide range of consequences in materials with biological, geophysical, and technological significance. Because such systems are often exposed to spatial or temporal variations in thermodynamic forcing, there are a host of fluid mechanical phenomena that result from this underlying melting behavior. The fluid dynamics of unfrozen surfaces holds clues for understanding the bulk behavior of polycrystalline materials, from Earth's mantle to the stratosphere and beyond. In this review we focus on the fluid dynamical consequences of the premelting of solids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.37.061903.175758
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    WALKING ON WATER: Biolocomotion at the Interface (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 339-369 
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    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: We consider the hydrodynamics of creatures capable of sustaining themselves on the water surface by means other than flotation. Particular attention is given to classifying water walkers according to their principal means of weight support and lateral propulsion. The various propulsion mechanisms are rationalized through consideration of energetics, hydrodynamic forces applied, or momentum transferred by the driving stroke. We review previous research in this area and suggest directions for future work. Special attention is given to introductory discussions of problems not previously treated in the fluid mechanics literature, with hopes of attracting physicists, applied mathematicians, and engineers to this relatively unexplored area of fluid mechanics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092157
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    SCALING: Wind Tunnel to Flight * (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 111-128 
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    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Wind tunnels have wide-ranging functionality, including many applications beyond aeronautics, and historically have been the major source of information for technological aerodynamics/aeronautical applications. There are a myriad of scaling issues/differences from flight to wind tunnel, and their study and impacts are uneven and a function of the particular type of extant flow phenomena. Typically, the most serious discrepancies are associated with flow separation. The tremendous ongoing increases in numerical simulation capability are changing and in many aspects have changed the function of the wind tunnel from a (scaled) "predictor" to a source of computational calibration/validation information with the computation then utilized as the flight prediction/scaling tool. Numerical simulations can increasingly include the influences of the various scaling issues. This wind tunnel role change has been occurring for decades as computational capability improves in all aspects. Additional issues driving this trend are the increasing cost (and time) disparity between physical experiments and computations, and increasingly stringent accuracy requirements.
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    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092208
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    NONLINEAR AND WAVE THEORY CONTRIBUTIONS OF T. BROOKE BENJAMIN (1929Đ??1995) * (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 1-25 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Brooke Benjamin's original theories of fluid mechanical phenomena changed our basic understanding of cavitation bubbles, surface and internal waves, gravity currents, instabilities of shear flow over flexible surfaces, and swirling flows. For some types of finite-amplitude wave phenomena, he generated integral constraints and derived new partial differential equations; by establishing their general properties he showed how they have wide application. He developed a complementary approach based on functional analysis that was quite new to fluid mechanics. He demonstrated methods for deriving, without detailed calculation, the essential features of nonlinear and indeterminate flow problems that are otherwise intractable.
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    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092028
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    EXPERIMENTAL FLUID MECHANICS OF PULSATILE ARTIFICIAL BLOOD PUMPS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 65-86 
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    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The fluid mechanics of artificial blood pumps has been studied since the early 1970s in an attempt to understand and mitigate hemolysis and thrombus formation by the device. Pulsatile pumps are characterized by inlet jets that set up a rotational "washing" pattern during filling. Strong regurgitant jets through the closed artificial heart valves have Reynolds stresses on the order of 10,000 dynes/cm2 and are the most likely cause of red blood cell damage and platelet activation. Although the flow in the pump chamber appears benign, low wall shear stresses throughout the pump cycle can lead to thrombus formation at the wall of the smaller pumps (10Đ??50 cc). The local fluid mechanics is critical. There is a need to rapidly measure or calculate the wall shear stress throughout the device so that the results may be easily incorporated into the design process.
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    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092022
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    FLUID MECHANICS AND HOMELAND SECURITY (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 87-110 
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    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Homeland security involves many applications of fluid mechanics and offers many opportunities for research and development. This review explores a wide selection of fluids topics in counterterrorism and suggests future directions. Broad topics range from preparedness and deterrence of impending terrorist attacks to detection, response, and recovery. Specific topics include aircraft hardening, blast mitigation, sensors and sampling, explosive detection, microfluidics and labs-on-a-chip, chemical plume dispersal in urban settings, and building ventilation. Also discussed are vapor plumes and standoff detection, nonlethal weapons, airborne disease spread, personal protective equipment, and decontamination. Involvement in these applications requires fluid dynamicists to think across the traditional boundaries of the field and to work with related disciplines, especially chemistry, biology, aerosol science, and atmospheric science.
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    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092111
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    CANNIBALISM, FOOD LIMITATION, INTRASPECIFIC COMPETITION, AND THE REGULATION OF SPIDER POPULATIONS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 441-465 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Cannibalism among generalist predators has implications for the dynamics of terrestrial food webs. Spiders are common, ubiquitous arthropod generalist predators in most natural and managed terrestrial ecosystems. Thus, the relationship of spider cannibalism to food limitation, competition, and population regulation has direct bearing on basic ecological theory and applications such as biological control. This review first briefly treats the different types of spider cannibalism and then focuses in more depth on evidence relating cannibalism to population dynamics and food web interactions to address the following questions: Is cannibalism in spiders a foraging strategy that helps to overcome the effects of a limited supply of calories and/or nutrients? Does cannibalism in spiders reduce competition for prey? Is cannibalism a significant density-dependent factor in spider population dynamics? Does cannibalism dampen spider-initiated trophic cascades?
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    PROSTAGLANDINS AND OTHER EICOSANOIDS IN INSECTS: Biological Significance (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 25-44 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Prostaglandins and other eicosanoids are oxygenated metabolites of certain polyunsaturated fatty acids. These compounds are well known for their important actions in mammalian physiology and disease. Recent work has revealed the presence and biological actions of eicosanoids in insects and many other invertebrate animals. In insects, eicosanoids mediate cellular immunity to microbial and metazoan challenge. Notably, some infectious organisms secrete factors responsible for impairing host insect immune reactions by inhibiting biosynthesis of eicosanoids. Eicosanoids also act in insect reproductive biology, in ion transport physiology, and in fever response to infection as well as in protein exocytosis in tick salivary glands. Aside from ongoing actions in homeostasis, certain eicosanoid actions occur at crucial points in insect life histories, such as during infectious challenge and important events in reproduction.
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    DEVELOPMENTS IN AQUATIC INSECT BIOMONITORING: A Comparative Analysis of Recent Approaches (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 495-523 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Aquatic insects and other benthic invertebrates are the most widely used organisms in freshwater biomonitoring of human impact. Because of the high monetary investment in freshwater management, decisions are often based on biomonitoring results, and a critical and comparative review of different approaches is required. We used 12 criteria that should be fulfilled by an "ideal" biomonitoring tool, addressing the rationale, implementation, and performance of a method. After illustrating how the century-old but still widely used Saprobian system does not meet these criteria, we apply them to nine recent approaches that range from the suborganismal to the ecosystem level. Although significant progress has been made in the field, no recent approach meets all 12 criteria. Given that the use of biomonitoring information has important financial consequences, we suggest that societies and governments prioritize how these criteria should be ranked.
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    BOTANICAL INSECTICIDES, DETERRENTS, AND REPELLENTS IN MODERN AGRICULTURE AND AN INCREASINGLY REGULATED WORLD (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 45-66 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Botanical insecticides have long been touted as attractive alternatives to synthetic chemical insecticides for pest management because botanicals reputedly pose little threat to the environment or to human health. The body of scientific literature documenting bioactivity of plant derivatives to arthropod pests continues to expand, yet only a handful of botanicals are currently used in agriculture in the industrialized world, and there are few prospects for commercial development of new botanical products. Pyrethrum and neem are well established commercially, pesticides based on plant essential oils have recently entered the marketplace, and the use of rotenone appears to be waning. A number of plant substances have been considered for use as insect antifeedants or repellents, but apart from some natural mosquito repellents, little commercial success has ensued for plant substances that modify arthropod behavior. Several factors appear to limit the success of botanicals, most notably regulatory barriers and the availability of competing products (newer synthetics, fermentation products, microbials) that are cost-effective and relatively safe compared with their predecessors. In the context of agricultural pest management, botanical insecticides are best suited for use in organic food production in industrialized countries but can play a much greater role in the production and postharvest protection of food in developing countries.
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    CONFLICT RESOLUTION IN INSECT SOCIETIES (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 581-608 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Although best known for cooperation, insect societies also manifest many potential conflicts among individuals. These conflicts involve both direct reproduction by individuals and manipulation of the reproduction of colony members. Here we review five major areas of reproductive conflict in insect societies: (a) sex allocation, (b) queen rearing, (c) male rearing, (d) queen-worker caste fate, and (e) breeding conflicts among totipotent adults. For each area we discuss the basis for conflict (potential conflict), whether conflict is expressed (actual conflict), whose interests prevail (conflict outcome), and the factors that reduce colony-level costs of conflict (conflict resolution), such as factors that cause workers to work rather than to lay eggs. Reproductive conflicts are widespread, sometimes having dramatic effects on the colony. However, three key factors (kinship, coercion, and constraint) typically combine to limit the effects of reproductive conflict and often lead to complete resolution.
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    DEFECATION BEHAVIOR AND ECOLOGY OF INSECTS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 635-661 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Whereas foraging has been a major focus of ecological and entomological research, its obligate partner, defecation, has been comparatively neglected. Insects exhibit a range of intriguing behavioral and morphological adaptations related to waste disposal in a range of contexts, including predator-prey interactions, hygiene, habitat location, reproduction, feeding, and shelter construction. Some insects, for example, make use of their own excrement as a physical or chemical defense against natural enemies, while others actively distance themselves from their waste material. Internally feeding insects, fluid-feeders, and social insects face particular challenges because their feeding behavior and/or site fidelity makes them especially vulnerable to problems associated with waste accumulation. As is true for foraging, ecological interactions involving defecation may have far-reaching evolutionary consequences and merit further study.
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    URL: http://dx.doi.org/10.1146/annurev.ento.49.061802.123212
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    CONCEPTS AND APPLICATIONS OF TRAP CROPPING IN PEST MANAGEMENT (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 285-308 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Interest in trap cropping, a traditional tool of pest management, has increased considerably in recent years. In this review we propose a broader definition of trap cropping that encompasses the inherent characteristics of the trap crop plants themselves as well as the strategies associated with their deployment. Inherent characteristics of a trap crop may include not only natural differential attractiveness for oviposition and feeding, but also other attributes that enable the trap crop plants to serve as a sink for insects or the pathogens they vector. Successful deployment of trap crops within a landscape depends on the inherent characteristics of the trap crop and the higher value crop, the spatial and temporal characteristics of each, the behavior and movement patterns of insect pests, and the agronomic and economic requirements of the production system. Thus, trap cropping is more knowledge-intensive than many other forms of pest management. We review recent references on trap cropping, classify them according to their modalities and level of implementation, and provide a synthesis of the factors that influence the success of trap cropping. Last, we provide a list of recommendations and guidelines that should prove helpful in moving trap cropping forward to its full potential.
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    THE ECOLOGICAL SIGNIFICANCE OF TALLGRASS PRAIRIE ARTHROPODS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 387-412 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Tallgrass prairie (TGP) arthropods are diverse and abundant, yet they remain poorly documented and there is still much to be learned regarding their ecological roles. Fire and grazing interact in complex ways in TGP, resulting in a shifting mosaic of resource quantity and quality for primary consumers. Accordingly, the impacts of arthropod herbivores and detritivores are expected to vary spatially and temporally. Herbivores generally do not control primary production. Rather, groups such as grasshoppers have subtle effects on plant communities, and their most significant impacts are often on forbs, which represent the bulk of plant diversity in TGP. Belowground herbivores and detritivores influence root dynamics and rhizosphere nutrient cycling, and above- and belowground groups interact through plant responses and detrital pathways. Large-bodied taxa, such as cicadas, can also redistribute significant quantities of materials during adult emergences. Predatory arthropods are the least studied in terms of ecological significance, but there is evidence that top-down processes are important in TGP.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151136
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    INSECT ODOR AND TASTE RECEPTORS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 113-135 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Insect odor and taste receptors are highly sensitive detectors of food, mates, and oviposition sites. Following the identification of the first insect odor and taste receptors in Drosophila melanogaster, these receptors were identified in a number of other insects, including the malaria vector mosquito Anopheles gambiae; the silk moth, Bombyx mori; and the tobacco budworm, Heliothis virescens. The chemical specificities of many of the D. melanogaster receptors, as well as a few of the A. gambiae and B. mori receptors, have now been determined either by analysis of deletion mutants or by ectopic expression in in vivo or heterologous expression systems. Here we discuss recent advances in our understanding of the molecular and cellular basis of odor and taste coding in insects.
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    INVASION BIOLOGY OF THRIPS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 67-89 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Thrips are among the stealthiest of insect invaders due to their small size and cryptic habits. Many invasive thrips are notorious for causing extensive crop damage, vectoring viral diseases, and permanently destabilizing IPM systems owing to irruptive outbreaks that require remediation with insecticides, leading to the development of insecticide resistance. Several challenges surface when attempting to manage incursive thrips species. Foremost among these is early recognition, followed by rapid and accurate identification of emergent pest species, elucidation of the region of origin, development of a management program, and the closing of conduits for global movement of thrips. In this review, we examine factors facilitating invasion by thrips, damage caused by these insects, pre- and post-invasion management tactics, and challenges looming on the horizon posed by invasive Thysanoptera, which continually challenge the development of sustainable management practices.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151044
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    EVOLUTION OF DEVELOPMENTAL STRATEGIES IN PARASITIC HYMENOPTERA (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 233-258 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Parasitoid wasps have evolved a wide spectrum of developmental interactions with hosts. In this review we synthesize and interpret results from the phylogenetic, ecological, physiological, and molecular literature to identify factors that have influenced the evolution of parasitoid developmental strategies. We first discuss the origins and radiation of the parasitoid lifestyle in the Hymenoptera. We then summarize how parasitoid developmental strategies are affected by ecological interactions and assess the inventory of physiological and molecular traits parasitoids use to successfully exploit hosts. Last, we discuss how certain parasitoid virulence genes have evolved and how these changes potentially affect parasitoid-host interactions. The combination of phylogenetic data with comparative and functional genomics offers new avenues for understanding the evolution of biological diversity in this group of insects.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151029
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    ASSESSING RISKS OF RELEASING EXOTIC BIOLOGICAL CONTROL AGENTS OF ARTHROPOD PESTS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 609-634 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: More than 5000 introductions of about 2000 species of exotic arthropod agents for control of arthropod pests in 196 countries or islands during the past 120 years rarely have resulted in negative environmental effects. Yet, risks of environmental effects caused by releases of exotics are of growing concern. Twenty countries have implemented regulations for release of biological control agents. Soon, the International Standard for Phytosanitary Measures (ISPM3) will become the standard for all biological control introductions worldwide, but this standard does not provide methods by which to assess environmental risks. This review summarizes documented nontarget effects and discusses the development and application of comprehensive and quick-scan environmental risk assessment methods.
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    PLANT CHEMISTRY AND NATURAL ENEMY FITNESS: Effects on Herbivore and Natural Enemy Interactions (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 163-185 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Tremendous strides have been made regarding our understanding of how host plant chemistry influences the interactions between herbivores and their natural enemies. While most work has focused on plant chemistry effects on host location and acceptance by natural enemies, an increasing number of studies examine negative effects. The tritrophic role of plant chemistry is central to several aspects of trophic phenomena including top-down versus bottom-up control of herbivores, enemy-free space and host choice, and theories of plant defense. Furthermore, tritrophic effects of plant chemistry are important in assessing the degree of compatibility between biological control and plant resistance approaches to pest control. Additional research is needed to understand the physiological effects of plant chemistry on parasitoids. Explicit tests are required to determine whether natural enemies can act as selective forces on plant defense. Finally, further studies of natural systems are crucial to understanding the evolution of multitrophic relationships.
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    BIZARRE INTERACTIONS AND ENDGAMES: Entomopathogenic Fungi and Their Arthropod Hosts (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 331-357 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Invertebrate pathogens and their hosts are taxonomically diverse. Despite this, there is one unifying concept relevant to all such parasitic associations: Both pathogen and host adapt to maximize their own reproductive output and ultimate fitness. The strategies adopted by pathogens and hosts to achieve this goal are almost as diverse as the organisms themselves, but studies examining such relationships have traditionally concentrated only on aspects of host physiology. Here we review examples of host-altered behavior and consider these within a broad ecological and evolutionary context. Research on pathogen-induced and host-mediated behavioral changes demonstrates the range of altered behaviors exhibited by invertebrates including behaviorally induced fever, elevation seeking, reduced or increased activity, reduced response to semiochemicals, and changes in reproductive behavior. These interactions are sometimes quite bizarre, intricate, and of great scientific interest.
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    SIGNALING AND FUNCTION OF INSULIN-LIKE PEPTIDES IN INSECTS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 1-24 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Insulin-like peptides (ILPs) exist in insects and are encoded by multigene families that are expressed in the brain and other tissues. Upon secretion, these peptides likely serve as hormones, neurotransmitters, and growth factors, but to date, few direct functions have been demonstrated. In Drosophila melanogaster, molecular genetic studies have revealed elements of a conserved insulin signaling pathway, and as in other animal models, it appears to play a key role in metabolism, growth, reproduction, and aging. This review offers (a) an integrated summary of the efforts to characterize the distribution of ILPs in insects and to define this pathway and its functions in Drosophila and (b) a few considerations for future studies of ILP endocrinology in insects.
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    MATING SYSTEMS OF BLOOD-FEEDING FLIES (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 413-440 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: The mating system of each species is a unique, dynamic suite of interactions between the sexes. In this review I describe these interactions in the families of flies that contain blood-feeding species. A transition from the aerial swarm, with rapid copulae and no direct female choice, to substrate-based systems with lengthy copulae and opportunities for female choice is evident at both a phylogenetic scale and within nematoceran families under specific ecological conditions. Female monogamy is associated with the former, polyandry with the latter. I suggest that the intensity of sexual selection operating on males in systems where the probability of mating is low has favored male ability to control female receptivity. Reproductive success of males is universally correlated to successful foraging for sugar or blood and (in some species and ecological conditions) to body size. Understanding the ecological basis of the mating systems of these flies will help formulate integrative, sustainable, and biologically lucid approaches for their control.
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    INSECT BIODIVERSITY OF BOREAL PEAT BOGS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 137-161 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Boreal peat bogs contain distinctive insects in addition to widely distributed generalists, including species restricted to bogs (tyrphobionts) and species characteristic of bogs but not confined to them (tyrphophiles). Bogs raised above the water table form characteristic habitat islands in southern boreal and temperate forest zones. Many bogs have persisted for hundreds and even thousands of years, preserving relict ecosystems related to subarctic biomes. The historical development and nature of individual bogs are reflected by differences among their insects, which are of great biogeographical and ecological interest. The environmental sensitivity of bogs also makes insects valuable as bioindicators. Moreover, few readily accessible bogs remain in a natural state. Given the scientific interest of bog insects and the fact that each relict bog habitat island is unique, further studies of the diversity of bog faunas are merited, and the conservation of these habitats should be strongly supported by entomologists.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151036
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    CURRENT TRENDS IN QUARANTINE ENTOMOLOGY * (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 359-385 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: With world trade in agricultural commodities increasing, the introduction of exotic insects into new areas where they become pests will increase. The development and application of quarantine treatments or other mitigation approaches to prevent pest introduction in traded commodities raise many research and regulatory issues. The probit 9 standard for quarantine treatment efficacy has given way to risk-based alternatives. Varietal testing may have merit for some treatments or commodities but not for others. Development of generic treatments to control broad groups of insects or insects in all commodities can expedite new trade in agricultural products. Area-wide pest management programs lower pest levels before harvest and improve the quarantine security provided by any postharvest treatments. Systems approaches capitalize on cumulative pest mortality from multiple control components to achieve quarantine security in an exported commodity. Certain quarantine treatment technologies such as irradiation are not universally accepted, which is slowing their adoption. Standardized phytosanitary measures and research protocols are needed to improve the flow of information when countries propose to trade in a regulated commodity.
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    URL: http://dx.doi.org/10.1146/annurev.ento.49.061802.123314
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    ROLE OF FXYD PROTEINS IN ION TRANSPORT (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 431-459 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: The FXYD proteins are a family of seven homologous single transmembrane segment proteins (FXYD1Đ??7), expressed in a tissue-specific fashion. The FXYD proteins modulate the function of Na,K-ATPase, thus adapting kinetic properties of active Na+ and K+ transport to the specific needs of different cells. Six FXYD proteins ( 1Đ??5, 7 ) are known to interact with Na,K-ATPase and affect its kinetic properties in specific ways. Although effects of FXYD proteins on parameters such as K1/2Na+, K1/2K+, KmATP, and Vmax are modest, usually twofold, these effects may have important long-term consequences for homeostasis of cation balance. In this review we summarize basic features of FXYD proteins and present recent evidence for functional effects, structure-function relations and structural interactions with Na,K-ATPase. We then discuss possible physiological roles, based on in vitro observations and newly available knockout mice models. Finally, we also consider evidence that FXYD proteins affect functioning of other ion transport systems.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.040104.131852
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    ENDOTHELIAL-CARDIOMYOCYTE INTERACTIONS IN CARDIAC DEVELOPMENT AND REPAIR (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 51-66 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Communication between endothelial cells and cardiomyocytes regulates not only early cardiac development but also adult cardiomyocyte function, including the contractile state. In the normal mammalian myocardium, each cardiomyocyte is surrounded by an intricate network of capillaries and is next to endothelial cells. Cardiomyocytes depend on endothelial cells not only for oxygenated blood supply but also for local protective signals that promote cardiomyocyte organization and survival. While endothelial cells direct cardiomyocytes, cardiomyocytes reciprocally secrete factors that impact endothelial cell function. Understanding how endothelial cells communicate with cardiomyocytes will be critical for cardiac regeneration, in which the ultimate goal is not simply to improve systolic function transiently but to establish new myocardium that is both structurally and functionally normal in the long term.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.040104.124629
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    PERMEATION AND SELECTIVITY OF TRP CHANNELS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 685-717 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Ion channels are pore-forming transmembrane proteins that allow ions to permeate biological membranes. Pore structure plays a crucial role in determining the ion permeation and selectivity properties of particular channels. In the past few decades, efforts have been undertaken to identify key elements of the pore regions of different classes of ion channels. In this review, we summarize current knowledge about permeation and selectivity of channel proteins from the transient receptor potential (TRP) superfamily. Whereas all TRP channels are permeable for cations, only two TRP channels are impermeable for Ca2+ (TRPM4, TRPM5), and two others are highly Ca2+ permeable (TRPV5, TRPV6). Despite the great advances in the TRP channel field during the past decade, only a limited number of reports have dealt with functional characterization of pore properties, biophysical aspects of cation permeation, or description of pore structures of TRP channels. This review gives an overview of available experimental and theoretical data and discusses the functional impact of pore-structure modifications on TRP channel properties.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.040204.101406
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    PROTECTING THE PUMP: Controlling Myocardial Inflammatory Responses (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 67-95 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Because of the anatomy, function, and nonregenerative nature of the myocardium, inflammation in this tissue is not well tolerated. Nevertheless, various diseases of the heart are characterized by inflammatory responses involving the effector mechanisms of innate and adaptive (lymphocyte-dependent) immunity. The innate immune response to ischemia-reperfusion injury is, by far, the most common cause of myocardial inflammation. Innate responses may have beneficial influences that preserve myocardial function in the short term but may be maladaptive in chronic states. Adaptive responses in the myocardium occur with infection or loss of tolerance, and lead to myocarditis. Given the narrow margin for benefit of cardiac inflammation, special regulatory mechanisms likely raise the threshold, compared to other tissues, for the induction and persistence of adaptive immune responses. These mechanisms include strong central and peripheral T cell tolerance to heart antigens and induction of anti-inflammatory feedback mechanisms involving cytokines such as interferon-??.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.040104.124611
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    LXRS AND FXR: The Yin and Yang of Cholesterol and Fat Metabolism (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 159-191 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that function as intracellular sensors for sterols and bile acids, respectively. In response to their ligands, these receptors induce transcriptional responses that maintain a balanced, finely tuned regulation of cholesterol and bile acid metabolism. LXRs also permit the efficient storage of carbohydrate- and fat-derived energy, whereas FXR activation results in an overall decrease in triglyceride levels and modulation of glucose metabolism. The elegant, dual interplay between these two receptor systems suggests that they coevolved to constitute a highly sensitive and efficient system for the maintenance of total body fat and cholesterol homeostasis. Emerging evidence suggests that the tissue-specific action of these receptors is also crucial for the proper function of the cardiovascular, immune, reproductive, endocrine pancreas, renal, and central nervous systems. Together, LXRs and FXR represent potential therapeutic targets for the treatment and prevention of numerous metabolic and lipid-related diseases.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.033104.152158
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    BRAINSTEM CIRCUITS REGULATING GASTRIC FUNCTION (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 279-305 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Brainstem parasympathetic circuits that modulate digestive functions of the stomach are comprised of afferent vagal fibers, neurons of the nucleus tractus solitarius (NTS), and the efferent fibers originating in the dorsal motor nucleus of the vagus (DMV). A large body of evidence has shown that neuronal communications between the NTS and the DMV are plastic and are regulated by the presence of a variety of neurotransmitters and circulating hormones as well as the presence, or absence, of afferent input to the NTS. These data suggest that descending central nervous system inputs as well as hormonal and afferent feedback resulting from the digestive process can powerfully regulate vago-vagal reflex sensitivity. This paper first reviews the essential "static" organization and function of vago-vagal gastric control neurocircuitry. We then present data on the opioidergic modulation of NTS connections with the DMV as an example of the "gating" of these reflexes, i.e., how neurotransmitters, hormones, and vagal afferent traffic can make an otherwise static autonomic reflex highly plastic.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.040504.094635
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    SGK KINASES AND THEIR ROLE IN EPITHELIAL TRANSPORT (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 461-490 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: The serum/glucocorticoid-induced kinase Sgk1 plays an important role in the regulation of epithelial ion transport. This kinase is very rapidly regulated at the transcriptional level as well as via posttranslational modifications involving phosphorylation by the MAP or PI-3 kinase pathways and/or ubiquitylation. Although Sgk1 is a cell survival kinase, its primary role likely concerns the regulation of epithelial ion transport, as suggested by the phenotype of Sgk1-null mice, which display a defect in Na+ homeostasis owing to disturbed renal tubular Na+ handling. In this review we first discuss the molecular, cellular, and regulatory aspects of Sgk1 and its paralogs. We then discuss its roles in the physiology and pathophysiology of epithelial ion transport.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.040104.131654
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    DESIGN AND FUNCTION OF SUPERFAST MUSCLES: New Insights into the Physiology of Skeletal Muscle (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 193-221 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Superfast muscles of vertebrates power sound production. The fastest, the swimbladder muscle of toadfish, generates mechanical power at frequencies in excess of 200 Hz. To operate at these frequencies, the speed of relaxation has had to increase approximately 50-fold. This increase is accomplished by modifications of three kinetic traits: (a) a fast calcium transient due to extremely high concentration of sarcoplasmic reticulum (SR)-Ca2+ pumps and parvalbumin, (b) fast off-rate of Ca2+ from troponin C due to an alteration in troponin, and (c) fast cross-bridge detachment rate constant (g, 50 times faster than that in rabbit fast-twitch muscle) due to an alteration in myosin. Although these three modifications permit swimbladder muscle to generate mechanical work at high frequencies (where locomotor muscles cannot), it comes with a cost: The high g causes a large reduction in attached force-generating cross-bridges, making the swimbladder incapable of powering low-frequency locomotory movements. Hence the locomotory and sound-producing muscles have mutually exclusive designs.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.040104.105418
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    CLAUDINS AND EPITHELIAL PARACELLULAR TRANSPORT (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 403-429 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Tight junctions form continuous intercellular contacts controlling solute movement through the paracellular pathway across epithelia. Paracellular barriers vary among epithelia in electrical resistance and behave as if they are lined with pores that have charge and size selectivity. Recent evidence shows that claudins, a large family (at least 24 members) of intercellular adhesion molecules, form the seal and its variable pore-like properties. This evidence comes from the study of claudins expressed in cultured epithelial cell models, genetically altered mice, and human mutants. We review information on the structure, function, and transcriptional and posttranslational regulation of the claudin family as well as of their evolutionarily distant relatives called the PMP22/EMP/MP20/claudin, or pfam00822, superfamily.
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    THE COMPARATIVE PHYSIOLOGY OF FOOD DEPRIVATION: From Feast to Famine (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 223-251 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: The ability of animals to survive food deprivation is clearly of considerable survival value. Unsurprisingly, therefore, all animals exhibit adaptive biochemical and physiological responses to the lack of food. Many animals inhabit environments in which food availability fluctuates or encounters with appropriate food items are rare and unpredictable; these species offer interesting opportunities to study physiological adaptations to fasting and starvation. When deprived of food, animals employ various behavioral, physiological, and structural responses to reduce metabolism, which prolongs the period in which energy reserves can cover metabolism. Such behavioral responses can include a reduction in spontaneous activity and a lowering in body temperature, although in later stages of food deprivation in which starvation commences, activity may increase as food-searching is activated. In most animals, the gastrointestinal tract undergoes marked atrophy when digestive processes are curtailed; this structural response and others seem particularly pronounced in species that normally feed at intermittent intervals. Such animals, however, must be able to restore digestive functions soon after feeding, and these transitions appear to occur at low metabolic costs.
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    REGULATION OF NORMAL AND CYSTIC FIBROSIS AIRWAY SURFACE LIQUID VOLUME BY PHASIC SHEAR STRESS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 543-561 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: The physical removal of viruses and bacteria on the mucociliary escalator is an important aspect of the mammalian lung's innate defense mechanism. The volume of airway surface liquid (ASL) present in the respiratory tract is a critical determinant of both mucus hydration and the rate of mucus clearance from the lung. ASL volume is maintained by the predominantly ciliated epithelium via coordinated regulation of (a) absorption, by the epithelial Na+ channel, and (b) secretion, by the Ca2+ -activated Cl channel (CaCC) and CFTR. This review provides an update on our current understanding of how shear stress regulates ASL volume height in normal and cystic fibrosis (CF) airway epithelia through extracellular ATP- and adenosine (ADO)-mediated pathways that modulate ion transport and ASL volume homeostasis. We also discuss (a) how derangement of the ADO-CFTR pathway renders CF airways vulnerable to viral infections that deplete ASL volume and produce mucus stasis, and (b) potential shear stressĐ??dependent therapies for CF.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.072304.112754
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    TRP CHANNELS IN C. ELEGANS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 719-736 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: The TRP (transient receptor potential) superfamily of cation channels is present in all eukaryotes, from yeast to mammals. Many TRP channels have been studied in the nematode Caenorhabditis elegans, revealing novel biological functions, regulatory modes, and mechanisms of localization. C. elegans TRPV channels function in olfaction, mechanosensation, osmosensation, and activity-dependent gene regulation. Their activity is regulated by G protein signaling and polyunsaturated fatty acids. C. elegans TRPPs related to human polycystic kidney disease genes are expressed in male-specific neurons. The KLP-6 kinesin directs TRPP channels to cilia, where they may interact with F0/F1 ATPases. A sperm-specific TRPC channel, TRP-3, is required for fertilization. Upon sperm activation, TRP-3 translocates from an intracellular compartment to the plasma membrane to allow store-operated Ca2+ entry. The TRPM channels GON-2 and GTL-2 regulate Mg2+ homeostasis and Mg2+ uptake by intestinal cells; GON-2 is also required for gonad development. The TRPML CUP-5 promotes normal lysosome biogenesis and prevents apoptosis. Dynamic, precise expression of TRP proteins generates a remarkable range of cellular functions.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.040204.100715
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    INSIGHTS ON TRP CHANNELS FROM IN VIVO STUDIES IN DROSOPHILA (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 649-684 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Transient receptor potential (TRP) channels mediate responses in a large variety of signaling mechanisms. Most studies on mammalian TRP channels rely on heterologous expression, but their relevance to in vivo tissues is not entirely clear. In contrast, Drosophila TRP and TRP-like (TRPL) channels allow direct analyses of in vivo function. In Drosophila photoreceptors, activation of TRP and TRPL is mediated via the phosphoinositide cascade, with both Ca2+ and diacylglycerol (DAG) essential for generating the light response. In tissue culture cells, TRPL channels are constitutively active, and lipid second messengers greatly facilitate this activity. Inhibition of phospholipase C (PLC) completely blocks lipid activation of TRPL, suggesting that lipid activation is mediated via PLC. In vivo studies in mutant Drosophila also reveal an acute requirement for lipid-producing enzyme, which may regulate PLC activity. Thus, PLC and its downstream second messengers, Ca2+ and DAG, constitute critical mediators of TRP/TRPL gating in vivo.
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    CARDIAC REGENERATION: Repopulating the Heart (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 29-49 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Many forms of pediatric and adult heart disease result from a deficiency in cardiomyocyte number. Through repopulation of the heart with new cardiomyocytes (that is, induction of regenerative cardiac growth), cardiac disease potentially can be reversed, provided that the newly formed myocytes structurally and functionally integrate in the preexisting myocardium. A number of approaches have been utilized to effect regenerative growth of the myocardium in experimental animals. These include interventions aimed at enhancing the ability of cardiomyocytes to proliferate in response to cardiac injury, as well as transplantation of cardiomyocytes or myogenic stem cells into diseased hearts. Here we review efforts to induce myocardial regeneration. We also provide a critical review of techniques currently used to assess cardiac regeneration and functional integration of de novo cardiomyocytes.
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    FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 123-158 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: The insulin resistance syndrome refers to a constellation of findings, including glucose intolerance, obesity, dyslipidemia, and hypertension, that promote the development of type 2 diabetes, cardiovascular disease, cancer, and other disorders. Defining the pathophysiological links between insulin resistance, the insulin resistance syndrome, and its sequelae is critical to understanding and treating these disorders. Over the past decade, two approaches have provided important insights into how changes in insulin signaling produce the spectrum of phenotypes associated with insulin resistance. First, studies using tissue-specific knockouts or tissue-specific reconstitution of the insulin receptor in vivo in mice have enabled us to deconstruct the insulin resistance syndromes by dissecting the contributions of different tissues to the insulin-resistant state. Second, in vivo and in vitro studies of the complex network of insulin signaling have provided insight into how insulin resistance can develop in some pathways whereas insulin sensitivity is maintained in others. These data, taken together, give us a framework for understanding the relationship between insulin resistance and the insulin resistance syndromes.
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    INTERSTITIAL CELLS OF CAJAL AS PACEMAKERS IN THE GASTROINTESTINAL TRACT (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 307-343 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: In the gastrointestinal tract, phasic contractions are caused by electrical activity termed slow waves. Slow waves are generated and actively propagated by interstitial cells of Cajal (ICC). The initiation of pacemaker activity in the ICC is caused by release of Ca2+ from inositol 1,4,5-trisphosphate (IP3) receptorĐ??operated stores, uptake of Ca2+ into mitochondria, and the development of unitary currents. Summation of unitary currents causes depolarization and activation of a dihydropyridine-resistant Ca2+ conductance that entrains pacemaker activity in a network of ICC, resulting in the active propagation of slow waves. Slow wave frequency is regulated by a variety of physiological agonists and conditions, and shifts in pacemaker dominance can occur in response to both neural and nonneural inputs. Loss of ICC in many human motility disorders suggests exciting new hypotheses for the etiology of these disorders.
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    AN INTRODUCTION TO TRP CHANNELS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 619-647 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: The aim of this review is to provide a basic framework for understanding the function of mammalian transient receptor potential (TRP) channels, particularly as they have been elucidated in heterologous expression systems. Mammalian TRP channel proteins form six-transmembrane (6-TM) cation-permeable channels that may be grouped into six subfamilies on the basis of amino acid sequence homology (TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML). Selected functional properties of TRP channels from each subfamily are summarized in this review. Although a single defining characteristic of TRP channel function has not yet emerged, TRP channels may be generally described as calcium-permeable cation channels with polymodal activation properties. By integrating multiple concomitant stimuli and coupling their activity to downstream cellular signal amplification via calcium permeation and membrane depolarization, TRP channels appear well adapted to function in cellular sensation. Our review of recent literature implicating TRP channels in neuronal growth cone steering suggests that TRPs may function more widely in cellular guidance and chemotaxis. The TRP channel gene family and its nomenclature, the encoded proteins and alternatively spliced variants, and the rapidly expanding pharmacology of TRP channels are summarized in online supplemental material.
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    COMMENTARY ON THE PLEASURES OF SOLVING IMPOSSIBLE PROBLEMS OF EXPERIMENTAL PHYSIOLOGY (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 1-28 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: This commentary presents a series of examples of "impossible experimental problems" that we have encountered over the years in addressing various challenging questions in physiology. We aim to show how stimulating the challenges of physiology can be and demonstrate how our naive invocation of methods from disparate fields of science and engineering has led to delightful resolutions of physiological challenges that were utterly new to this intrepid interdisciplinary researcher.
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    NUCLEAR AND MITOCHONDRIAL COMPARTMENTATION OF OXIDATIVE STRESS AND REDOX SIGNALING (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 46 (2006), S. 215-234 
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    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: New methods to measure thiol oxidation show that redox compartmentation functions as a mechanism for specificity in redox signaling and oxidative stress. Redox Western analysis and redox-sensitive green fluorescent proteins provide means to quantify thiol/disulfide redox changes in specific subcellular compartments. Analyses using these techniques show that the relative redox states from most reducing to most oxidizing are mitochondria 〉 nuclei 〉 cytoplasm 〉 endoplasmic reticulum 〉 extracellular space. Mitochondrial thiols are an important target of oxidant-induced apoptosis and necrosis and are especially vulnerable to oxidation because of the relatively alkaline pH. Maintenance of a relatively reduced nuclear redox state is critical for transcription factor binding in transcriptional activation in response to oxidative stress. The new methods are applicable to a broad range of experimental systems and their use will provide improved understanding of the pharmacologic and toxicologic actions of drugs and toxicants.
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    TICK PHEROMONES AND THEIR USE IN TICK CONTROL (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 557-580 
    Details
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Tick pheromones that regulate assembly, attraction/aggregation/attachment, and mating behavior have been described. Most of the compounds regulating these behaviors are purines, substituted phenols, or cholesteryl esters. Other pheromonal compounds include organic acids, hematin, or ecdysteroids. Novel devices have been developed that combine the specific compounds comprising these pheromones with an acaricide. When applied to tick-infested vegetation or directly to the body surfaces of livestock or companion animals, these devices are effective for tick control. This review summarizes the current state of knowledge of tick pheromones. In addition, this review also presents examples illustrating how devices using tick pheromones can offer effective alternatives to conventional methods for achieving tick control.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151150
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    BIOGEOGRAPHIC AREAS AND TRANSITION ZONES OF LATIN AMERICA AND THE CARIBBEAN ISLANDS BASED ON PANBIOGEOGRAPHIC AND CLADISTIC ANALYSES OF THE ENTOMOFAUNA (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 467-494 
    Details
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Track and cladistic biogeographic analyses based on insect taxa are used as a framework to interpret patterns of the Latin American and Caribbean entomofauna by identifying biogeographic areas on the basis of endemicity and arranging them hierarchically in a system of regions, subregions, dominions, and provinces. The Nearctic region, inhabited by Holarctic insect taxa, comprises five provinces: California, Baja California, Sonora, Mexican Plateau, and Tamaulipas. The Mexican transition zone comprises five provinces: Sierra Madre Occidental, Sierra Madre Oriental, Transmexican Volcanic Belt, Balsas Basin, and Sierra Madre del Sur. The Neotropical region, which harbors many insect taxa with close relatives in the tropical areas of the Old World, comprises four subregions: Caribbean, Amazonian, Chacoan, and Parana. The South American transition zone comprises five provinces: North Andean Paramo, Coastal Peruvian Desert, Puna, Atacama, Prepuna, and Monte. The Andean region, which harbors insect taxa with close relatives in the Austral continents, comprises three subregions: Central Chilean, Subantarctic, and Patagonian.
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    URL: http://dx.doi.org/10.1146/annurev.ento.50.071803.130447
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    TACHINIDAE: Evolution, Behavior, and Ecology (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 525-555 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Tachinidae are one of the most diverse and ecologically important families in the order Diptera. As parasitoids, they are important natural enemies in most terrestrial ecological communities, particularly as natural enemies of larval Lepidoptera. Despite their diversity and ecological impact, relatively little is known about the evolution and ecology of tachinids, and what is known tends to be widely dispersed in specialized reports, journals, or texts. In this review we synthesize information on the evolutionary history, behavior, and ecology of tachinids and discuss promising directions for future research involving tachinids. We provide an overview of the phylogenetic history and geographic diversity of tachinids, examine the evolution of oviposition strategies and host associations, review known mechanisms of host location, and discuss recent studies dealing with the ecological interactions between tachinids and their hosts. In doing so, we highlight ways in which investigation of these parasitoids provides insight into such topics as biogeographic patterns of diversity, the evolution of ecological specialization, the tritrophic context of enemy-herbivore interactions, and the role of host location behavior in shaping host range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151133
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    STRUCTURE OF THE MUSHROOM BODIES OF THE INSECT BRAIN (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 209-232 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: The past decade has produced an explosion of new information on the development, neuroanatomy, and possible functions of the mushroom bodies. This review provides a concise, contemporary overview of the structure of the mushroom bodies. Two topics are highlighted: the volume plasticity of mushroom body neuropils evident in the brains of some adult insects and a possible essential role for the ?? lobe in olfactory memory.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.150954
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    INSECT VECTORS OF PHYTOPLASMAS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 91-111 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Plant diseases caused by, or associated with, phytoplasmas occur in hundreds of commercial and native plants, causing minor to extensive damage. Insect vectors, primarily leafhoppers, planthoppers, and psyllids, have been identified for relatively few phytoplasma diseases, limiting the capacity of managers to make informed decisions to protect crops and endangered indigenous plants. In the past two decades our knowledge of insect vectorĐ??phytoplasma interactions has increased dramatically, allowing researchers to make more accurate predictions about the nature and epidemiology of phytoplasma diseases. These better-characterized systems also may provide clues to the identity of insect vectors of other phytoplasma-associated diseases. We review the literature addressing the ecology of insect vectors, phytoplasma-insect ecological and molecular interactions, vector movement and dispersal, and possible management strategies with an emphasis on research from the past 20 years.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151039
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    APPARENT COMPETITION, QUANTITATIVE FOOD WEBS, AND THE STRUCTURE OF PHYTOPHAGOUS INSECT COMMUNITIES (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 187-208 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Phytophagous insects and their natural enemies make up one of the largest and most diverse groups of organisms on earth. Ecological processes, in particular negative indirect effects mediated by shared natural enemies (apparent competition), may be important in structuring phytophagous insect communities. The potential for indirect interactions can be assessed by analyzing the trophic structure of insect communities, and we claim that quantitative food webs are particularly well suited for this task. We review the experimental evidence for both short-term and long-term apparent competition in phytophagous insect communities and discuss the possible interactions between apparent competition and intraguild predation or shared mutualists. There is increasing evidence for the importance of trait-mediated as well as density-mediated indirect effects. We conclude that there is a need for large-scale experiments manipulating communities in their entirety and a greater integration of community and chemical ecology.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151120
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    PLANT-MEDIATED INTERACTIONS BETWEEN PATHOGENIC MICROORGANISMS AND HERBIVOROUS ARTHROPODS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 663-689 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Plant-mediated interactions between pathogenic microorganisms and arthropod herbivores occur when arthropod infestation or pathogen infection changes the shared host plant in ways that affect a subsequent attacker of the opposite type. Interest in such "tripartite" interactions has increased as the ecological and plant physiological framework for understanding and contextualizing them has developed. The outcomes of plant-mediated interactions are variable, and only a few provisional patterns can be identified at present. However, these interactions can have important consequences not only for individual pathogens and herbivores, but also for the population dynamics of both types of organisms in managed and natural ecosystems. Research has focused on the role of two plant response pathways in mediating tripartite interactions, one involving jasmonic acid and the other salicylic acid. Further studies of plant-mediated interactions will facilitate an understanding of how plants coordinate and integrate their defenses against multiple biotic threats.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151117
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    DOPA DECARBOXYLASE: A Model Gene-Enzyme System for Studying Development, Behavior, and Systematics (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 259-284 
    Details
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Throughout its long evolutionary history, the Dopa decarboxylase gene (Ddc) has acquired a variety of functions in insects. The enzyme (DDC) catalyzes the production of the neural transmitters dopamine and serotonin. Not surprisingly, evidence of the enzyme's involvement in the behavior of insects is beginning to accumulate. In addition, DDC plays a role in wound healing, parasite defense, pigmentation, and cuticle hardening. A high degree of sequence conservation has allowed comparisons of the Ddc-coding regions from various insects, facilitating a number of recent studies on insect systematics. This review outlines the diverse functions of Ddc and illustrates how studies of this model system address many questions on insect neurobiology, developmental biology, and systematics.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151143
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    HOST PLANT SELECTION BY APHIDS: Behavioral, Evolutionary, and Applied Perspectives (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 309-330 
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    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: As phloem feeders and major vectors of plant viruses, aphids are important pests of agricultural and horticultural crops worldwide. The processes of aphid settling and reproduction on plants therefore have a direct economic impact, and a better understanding of these events may lead to improved management strategies. Aphids are also important model organisms in the analysis of population differentiation and speciation in animals, and new ideas on plant utilization influence our understanding of the mechanisms generating biological diversity. Recent research suggests that the dominant cues controlling plant preference and initiation of reproduction are detected early during the stylet penetration process, well before the nutrient supply (phloem) is contacted. Aphids regularly puncture cells along the stylet pathway and ingest cytosolic samples, and the cues stimulating settling and parturition likely are metabolites present in peripheral (nonvascular) plant cells. We discuss these findings and their implications for aphid evolution and management.
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    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151107
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    HUMAN FLAVIN-CONTAINING MONOOXYGENASES (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 46 (2006), S. 65-100 
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    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: This review summarizes recent information concerning the pharmacological and toxicological significance of the human flavin-containing monooxygenase (FMO, EC 1.14.13.8). The human FMO oxygenates nucleophilic heteroatom-containing chemicals and drugs and generally converts them into harmless, polar, readily excreted metabolites. Sometimes, however, FMO bioactivates chemicals into reactive materials that can cause toxicity. Most of the interindividual differences of FMO are due to genetic variability and allelic variation, and splicing variants may contribute to interindividual and interethnic variability observed for FMO-mediated metabolism. In contrast to cytochrome P450 (CYP), FMO is not easily induced nor readily inhibited, and potential adverse drug-drug interactions are minimized for drugs prominently metabolized by FMO. These properties may provide advantages in drug design and discovery, and by incorporating FMO detoxication pathways into drug candidates, more drug-like materials may be forthcoming. Although exhaustive examples are not available, physiological factors can influence FMO function, and this may have implications for the clinical significance of FMO and a role in human disease.
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    URL: http://dx.doi.org/10.1146/annurev.pharmtox.46.120604.141043
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    PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: How Their Effects on Macrophages Can Lead to the Development of a New Drug Therapy Against Atherosclerosis (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 46 (2006), S. 1-39 
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    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: Peroxisome proliferator-activated receptors (PPARs) alpha (ʼ̛), beta/delta (?‚/??), and gamma (??) are members of the nuclear receptor superfamily, which also includes the estrogen, androgen, and glucocorticoid receptors. Recent evidence suggests that PPARs regulate genes involved in lipid metabolism, glucose homeostasis, and inflammation in various tissues; however, the mechanisms involved are not completely understood. Anti-diabetic drugs, called glitazones, can selectively activate PPAR??, and hypolipidemic drugs, called fibrates, can weakly activate PPARʼ̛. Both classes of drugs can decrease insulin resistance and dyslipidemias, which also makes them attractive for treating the metabolic syndrome. The metabolic syndrome exhibits a constellation of risk factors for atherosclerosis that include obesity, insulin resistance, dyslipidemias, and hypertension. Interestingly, all three PPARs are present in macrophages and can therefore have a profound effect on several disease processes, including atherosclerosis. Macrophages are key players in atherosclerotic lesion development. Currently, the first line of defense in reducing the risk of atherosclerosis is aimed at lowering low-density lipoproteins (LDL) and raising high-density lipoproteins (HDL), but a large percentage of patients on statins still succumb to coronary artery disease. However, with the development of drugs selectively activating PPARs, a new arsenal of drugs specifically targeting to the macrophage/foam cell may potentially have a profound impact on how we treat cardiovascular disease.
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    URL: http://dx.doi.org/10.1146/annurev.pharmtox.46.120604.141247
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    THE REGULATION AND PHARMACOLOGY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 46 (2006), S. 235-276 
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    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates significant and diverse signaling functions in nearly every organ system in the body. The endothelial isoform of nitric oxide synthase (eNOS) is a key source of NO found in the cardiovascular system. This review summarizes the pharmacology of NO and the cellular regulation of endothelial NOS (eNOS). The molecular intricacies of the chemistry of NO and the enzymology of NOSs are discussed, followed by a review of the biological activities of NO. This information is then used to develop a more global picture of the pharmacological control of NO synthesis by NOSs in both physiologic conditions and pathophysiologic states.
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    URL: http://dx.doi.org/10.1146/annurev.pharmtox.44.101802.121844
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    CYTOCHROME P450 AND XENOBIOTIC RECEPTOR HUMANIZED MICE * (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 46 (2006), S. 41-64 
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    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: Most xenobiotics that enter the body are subjected to metabolism that functions primarily to facilitate their elimination. Metabolism of certain xenobiotics can also result in the production of electrophilic derivatives that can cause cell toxicity and transformation. Many xenobiotics can also activate receptors that in turn induce the expression of genes encoding xenobiotic-metabolizing enzymes and xenobiotic transporters. However, there are marked species differences in the way mammals respond to xenobiotics, which are due in large part to molecular differences in receptors and xenobiotic-metabolizing enzymes. This presents a problem in extrapolating data obtained with rodent model systems to humans. There are also polymorphisms in xenobiotic-metabolizing enzymes that can impact drug therapy and cancer susceptibility. In an effort to generate more reliable in vivo systems to study and predict human response to xenobiotics, humanized mice are under development.
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    URL: http://dx.doi.org/10.1146/annurev.pharmtox.45.120403.100007
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    CHRONIC EFFECTS OF MECHANICAL FORCE ON AIRWAYS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 563-583 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Airways are embedded in the mechanically dynamic environment of the lung. In utero, this mechanical environment is defined largely by fluid secretion into the developing airway lumen. Clinical, whole lung, and cellular studies demonstrate pivotal roles for mechanical distention in airway morphogenesis and cellular behavior during lung development. In the adult lung, the mechanical environment is defined by a dynamic balance of surface, tissue, and muscle forces. Diseases of the airways modulate both the mechanical stresses to which the airways are exposed as well as the structure and mechanical behavior of the airways. For instance, in asthma, activation of airway smooth muscle abruptly changes the airway size and stress state within the airway wall; asthma also results in profound remodeling of the airway wall. Data now demonstrate that airway epithelial cells, smooth muscle cells, and fibroblasts respond to their mechanical environment. A prominent role has been identified for the epithelium in transducing mechanical stresses, and in both the fetal and mature airways, epithelial cells interact with mesenchymal cells to coordinate remodeling of tissue architecture in response to the mechanical environment.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.072304.113102
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    THE ASSOCIATION OF NHERF ADAPTOR PROTEINS WITH G PROTEINĐ??COUPLED RECEPTORS AND RECEPTOR TYROSINE KINASES * (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 491-505 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: The sodium-hydrogen exchanger regulatory factors (NHERF-1 and NHERF-2) are a family of adaptor proteins characterized by the presence of two tandem PDZ protein interaction domains and a C-terminal domain that binds the cytoskeleton proteins ezrin, radixin, moesin, and merlin. The NHERF proteins are highly expressed in the kidney, small intestine, and other organs, where they associate with a number of transporters and ion channels, signaling proteins, and transcription factors. Recent evidence has revealed important associations between the NHERF proteins and several G proteinĐ??coupled receptors such as the ?‚2-adrenergic receptor, the ?”-opioid receptor, and the parathyroid hormone receptor, as well as growth factor tyrosine kinase receptors such as the platelet-derived growth factor receptor and the epidermal growth factor receptor. This review summarizes the emerging data on the biochemical mechanisms, physiologic outcomes, and potential clinical implications of the assembly and disassembly of receptor/NHERF complexes.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.040104.131050
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    CNG AND HCN CHANNELS: Two Peas, One Pod (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 375-401 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Cyclic nucleotideĐ??activated ion channels play a fundamental role in a variety of physiological processes. By opening in response to intracellular cyclic nucleotides, they translate changes in concentrations of signaling molecules to changes in membrane potential. These channels belong to two families: the cyclic nucleotideĐ??gated (CNG) channels and the hyperpolarization-activated cyclic nucleotideĐ??modulated (HCN) channels. The two families exhibit high sequence similarity and belong to the superfamily of voltage-gated potassium channels. Whereas HCN channels are activated by voltage and CNG channels are virtually voltage independent, both channels are activated by cyclic nucleotide binding. Furthermore, the channels are thought to have similar channel structures, leading to similar mechanisms of activation by cyclic nucleotides. However, although these channels are structurally and behaviorally similar, they have evolved to perform distinct physiological functions. This review describes the physiological roles and biophysical behavior of CNG and HCN channels. We focus on how similarities in structure and activation mechanisms result in common biophysical models, allowing CNG and HCN channels to be viewed as a single genre.
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    OXIDATIVE STRESS IN MARINE ENVIRONMENTS: Biochemistry and Physiological Ecology (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 253-278 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Oxidative stressĐ??the production and accumulation of reduced oxygen intermediates such as superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicalsĐ??can damage lipids, proteins, and DNA. Many disease processes of clinical interest and the aging process involve oxidative stress in their underlying etiology. The production of reactive oxygen species is also prevalent in the world's oceans, and oxidative stress is an important component of the stress response in marine organisms exposed to a variety of insults as a result of changes in environmental conditions such as thermal stress, exposure to ultraviolet radiation, or exposure to pollution. As in the clinical setting, reactive oxygen species are also important signal transduction molecules and mediators of damage in cellular processes, such as apoptosis and cell necrosis, for marine organisms. This review brings together the voluminous literature on the biochemistry and physiology of oxidative stress from the clinical and plant physiology disciplines with the fast-increasing interest in oxidative stress in marine environments.
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    THE CONTRIBUTION OF BIOPHYSICAL LUNG INJURY TO THE DEVELOPMENT OF BIOTRAUMA (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 585-618 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Patients with severe acute respiratory distress syndrome who die usually succumb to multiorgan failure as opposed to hypoxia. Despite appropriate resuscitation, some patients' symptoms persist on a downward spiral, apparently propagated by an uncontained systemic inflammatory response. This phenomenon is not well understood. However, a novel hypothesis to explain this observation proposes that it is related to the life-saving ventilatory support used to treat the respiratory failure. According to this hypothesis, mechanical ventilation per se, by alterating both the magnitude and the pattern of lung stretch, can cause changes in gene expression and/or cellular metabolism that ultimately can lead to the development of an overwhelming inflammatory responseĐ??even in the absence of overt structural damage. This mechanism of injury has been termed biotrauma. In this review we explore the biotrauma hypothesis, the causal relationship between biophysical injury and organ failure, and its implications for the future therapy and management of critically ill patients.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.072304.113443
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    SIGNALING FOR CONTRACTION AND RELAXATION IN SMOOTH MUSCLE OF THE GUT (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 345-374 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Phosphorylation of Ser19 on the 20-kDa regulatory light chain of myosin II (MLC20) by Ca2+/calmodulin-dependent myosin light-chain kinase (MLCK) is essential for initiation of smooth muscle contraction. The initial [Ca2+]i transient is rapidly dissipated and MLCK inactivated, whereas MLC20 and muscle contraction are well maintained. Sustained contraction does not reflect Ca2+ sensitization because complete inhibition of MLC phosphatase activity in the absence of Ca2+ induces smooth muscle contraction. This contraction is suppressed by staurosporine, implying participation of a Ca2+-independent MLCK. Thus, sustained contraction, as with agonist-induced contraction at experimentally fixed Ca2+ concentrations, involves (a) G protein activation, (b) regulated inhibition of MLC phosphatase, and (c) MLC20 phosphorylation via a Ca2+-independent MLCK. The pathways that lead to inhibition of MLC phosphatase by Gq/13-coupled receptors are initiated by sequential activation of Gʼ̛q/ʼ̛13, RhoGEF, and RhoA, and involve Rho kinaseĐ??mediated phosphorylation of the regulatory subunit of MLC phosphatase (MYPT1) and/or PKC-mediated phosphorylation of CPI-17, an endogenous inhibitor of MLC phosphatase. Sustained MLC20 phosphorylation is probably induced by the Ca2+-independent MLCK, ZIP kinase. The pathways initiated by Gi-coupled receptors involve sequential activation of G?‚??i, PI 3-kinase, and the Ca2+-independent MLCK, integrin-linked kinase. The last phosphorylates MLC20 directly and inhibits MLC phosphatase by phosphorylating CPI-17. PKA and PKG, which mediate relaxation, act upstream to desensitize the receptors (VPAC2 and NPR-C), inhibit adenylyl and guanylyl cyclase activities, and stimulate cAMP-specific PDE3 and PDE4 and cGMP-specific PDE5 activities. These kinases also act downstream to inhibit (a) initial contraction by inhibiting Ca2+ mobilization and (b) sustained contraction by inhibiting RhoA and targets downstream of RhoA. This increases MLC phosphatase activity and induces MLC20 dephosphorylation and muscle relaxation.
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    TRANSCRIPTION FACTORS AND CONGENITAL HEART DEFECTS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 97-121 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Although there have been important advances in diagnostic modalities and therapeutic strategies for congenital heart defects (CHD), these malformations still lead to significant morbidity and mortality in the human population. Over the past 10 years, characterization of the genetic causes of CHD has begun to elucidate some of the molecular causes of these defects. Linkage analysis and candidate-gene approaches have been used to identify gene mutations that are associated with both familial and sporadic cases of CHD. Complementation of the human studies with developmental studies in mouse models provides information for the roles of these genes in normal development as well as indications for disease pathogenesis. Biochemical analysis of these gene mutations has provided further insight into the molecular effects of these genetic mutations. Here we review genetic, developmental, and biochemical studies of six cardiac transcription factors that have been identified as genetic causes for CHD in humans.
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    URL: http://dx.doi.org/10.1146/annurev.physiol.68.040104.113828
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    STRESS TRANSMISSION IN THE LUNG: Pathways from Organ to Molecule (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 507-541 
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    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Gas exchange, the primary function of the lung, can come about only with the application of physical forces on the macroscale and their transmission to the scale of small airway, small blood vessel, and alveolus, where they serve to distend and stabilize structures that would otherwise collapse. The pathway for force transmission then continues down to the level of cell, nucleus, and molecule; moreover, to lesser or greater degrees most cell types that are resident in the lung have the ability to generate contractile forces. At these smallest scales, physical forces serve to distend the cytoskeleton, drive cytoskeletal remodeling, expose cryptic binding domains, and ultimately modulate reaction rates and gene expression. Importantly, evidence has now accumulated suggesting that multiscale phenomena span these scales and govern integrative lung behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.physiol.68.072304.114110
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    Electronic Resource
    CO AS A CELLULAR SIGNALING MOLECULE (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 46 (2006), S. 411-449 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: Many biological functions of heme oxygenase (HO), such as cytoprotection against oxidative stress, vasodilation, neurotransmission in the central or peripheral nervous systems, and anti-inflammatory, anti-apoptotic, or anti-proliferative potential, have been attributed to its enzymatic byproduct carbon monoxide (CO), although roles for biliverdin/bilirubin and iron have also been proposed. In addition to these well-characterized effects, recent findings reveal that HO-derived CO may act as an oxygen sensor and circadian modulator of heme biosynthesis. In lymphocytes, CO may participate in regulatory T cell function. A number of the known signaling effects of CO depend on stimulation of soluble guanylate cyclase and/or activation of mitogen-activated protein kinases (MAPK). Furthermore, modulation of caveolin-1 status may serve as an essential component of certain aspects of CO action, such as growth control. In this review, we summarize recent findings of the beneficial or detrimental effects of endogenous CO with an emphasis on the signaling pathways and downstream targets that trigger the action of this gas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pharmtox.46.120604.141053
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