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  • Journals
  • Articles  (753)
  • Female  (515)
  • Models, Biological  (136)
  • Protein Conformation  (117)
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Collection
  • Journals
  • Articles  (753)
Source
Keywords
Publisher
Years
  • 2020-2022
  • 2015-2019  (179)
  • 2005-2009  (574)
  • 1990-1994
  • 1975-1979
Year
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Topic
  • 1
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    A receptor that mediates the post-mating switch in Drosophila reproductive behaviour (2007)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2007
    Description: Mating in many species induces a dramatic switch in female reproductive behaviour. In most insects, this switch is triggered by factors present in the male's seminal fluid. How these factors exert such profound effects in females is unknown. Here we identify a receptor for the Drosophila melanogaster sex peptide (SP, also known as Acp70A), the primary trigger of post-mating responses in this species. Females that lack the sex peptide receptor (SPR, also known as CG16752), either entirely or only in the nervous system, fail to respond to SP and continue to show virgin behaviours even after mating. SPR is expressed in the female's reproductive tract and central nervous system. The behavioural functions of SPR map to the subset of neurons that also express the fruitless gene, a key determinant of sex-specific reproductive behaviour. SPR is highly conserved across insects, opening up the prospect of new strategies to control the reproductive and host-seeking behaviours of agricultural pests and human disease vectors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yapici, Nilay -- Kim, Young-Joon -- Ribeiro, Carlos -- Dickson, Barry J -- England -- Nature. 2008 Jan 3;451(7174):33-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18066048" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Central Nervous System/metabolism ; Conserved Sequence ; Copulation/physiology ; Drosophila Proteins/chemistry/deficiency/genetics/*metabolism ; Drosophila melanogaster/cytology/*physiology ; Female ; Genitalia, Female/metabolism ; Male ; Nerve Tissue Proteins/metabolism ; Neurons/metabolism ; Peptides/chemistry/deficiency/genetics/*metabolism ; Sexual Behavior, Animal/*physiology ; Substrate Specificity ; Transcription Factors/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Altruistic helping in human infants and young chimpanzees (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-03-04
    Description: Human beings routinely help others to achieve their goals, even when the helper receives no immediate benefit and the person helped is a stranger. Such altruistic behaviors (toward non-kin) are extremely rare evolutionarily, with some theorists even proposing that they are uniquely human. Here we show that human children as young as 18 months of age (prelinguistic or just-linguistic) quite readily help others to achieve their goals in a variety of different situations. This requires both an understanding of others' goals and an altruistic motivation to help. In addition, we demonstrate similar though less robust skills and motivations in three young chimpanzees.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warneken, Felix -- Tomasello, Michael -- New York, N.Y. -- Science. 2006 Mar 3;311(5765):1301-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental and Comparative Psychology, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany. warneken@eva.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16513986" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Altruism ; Animals ; Behavior, Animal ; Child, Preschool ; Female ; *Helping Behavior ; Humans ; Male ; Motivation ; Pan troglodytes/*psychology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Debating sexual selection and mating strategies (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-05-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ghiselin, Michael T -- New York, N.Y. -- Science. 2006 May 5;312(5774):689-97; author reply 689-97.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16680820" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Male ; *Sexual Behavior, Animal ; *Social Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Paleoanthropology. Lucy's 'child' offers rare glimpse of an ancient toddler (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2006 Sep 22;313(5794):1716.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16990523" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone and Bones/anatomy & histology ; Ethiopia ; Female ; *Fossils ; *Hominidae/anatomy & histology/growth & development ; Paleodontology ; Skeleton ; Skull/anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Women in science. MIT hiring controversy sparks faculty fracas (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-07-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2006 Jul 21;313(5785):284.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16857909" target="_blank"〉PubMed〈/a〉
    Keywords: *Faculty ; Female ; Humans ; Massachusetts ; *Neurosciences ; *Personnel Selection ; Prejudice ; Universities/*manpower ; *Women, Working
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Chemistry. Seamless proteins tie up their loose ends (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-03-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Craik, David J -- New York, N.Y. -- Science. 2006 Mar 17;311(5767):1563-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia. d.craik@imb.uq.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16543448" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-HIV Agents/chemistry/pharmacology ; Anti-Infective Agents/chemistry/pharmacology ; Bacterial Proteins/biosynthesis/chemistry/pharmacology ; Codon, Terminator ; Cyclization ; Cyclotides/biosynthesis/*chemistry/pharmacology ; Defensins/biosynthesis/chemistry/genetics/pharmacology ; Drug Design ; Humans ; Peptides, Cyclic/biosynthesis/*chemistry ; Plant Proteins/biosynthesis/chemistry/pharmacology ; Protein Biosynthesis ; Protein Conformation ; Protein Denaturation ; Protein Engineering ; Protein Folding ; Protein Precursors/metabolism ; Proteins/*chemistry/metabolism/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    HIV testing and individual rights (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-10-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mills, Edward -- Rennie, Stuart -- New York, N.Y. -- Science. 2006 Oct 20;314(5798):417-9; author reply 417-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17053128" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Serodiagnosis ; Female ; HIV Infections/*diagnosis/prevention & control ; *Human Rights ; Humans ; Male ; Mandatory Testing ; Prejudice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Ecology. Staying connected in a turbulent world (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-01-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steneck, Robert S -- New York, N.Y. -- Science. 2006 Jan 27;311(5760):480-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Marine Sciences, University of Maine, Darling Marine Center, Walpole, ME 04573, USA. steneck@maine.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16439653" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthozoa ; Caribbean Region ; Computer Simulation ; Conservation of Natural Resources ; *Ecosystem ; Fishes/growth & development/*physiology ; Larva/physiology ; Models, Biological ; Population Dynamics ; *Seawater ; *Swimming ; Water Movements
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Language control in the bilingual brain (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-06-10
    Description: How does the bilingual brain distinguish and control which language is in use? Previous functional imaging experiments have not been able to answer this question because proficient bilinguals activate the same brain regions irrespective of the language being tested. Here, we reveal that neuronal responses within the left caudate are sensitive to changes in the language or the meaning of words. By demonstrating this effect in populations of German-English and Japanese-English bilinguals, we suggest that the left caudate plays a universal role in monitoring and controlling the language in use.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crinion, J -- Turner, R -- Grogan, A -- Hanakawa, T -- Noppeney, U -- Devlin, J T -- Aso, T -- Urayama, S -- Fukuyama, H -- Stockton, K -- Usui, K -- Green, D W -- Price, C J -- 051067/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2006 Jun 9;312(5779):1537-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Department of Imaging Neuroscience, University College London, London WC1N 3BG, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16763154" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Mapping ; Caudate Nucleus/*physiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; *Multilingualism ; Neurons/physiology ; Positron-Emission Tomography ; Semantics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    The fluorescent toolbox for assessing protein location and function (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-04-15
    Description: Advances in molecular biology, organic chemistry, and materials science have recently created several new classes of fluorescent probes for imaging in cell biology. Here we review the characteristic benefits and limitations of fluorescent probes to study proteins. The focus is on protein detection in live versus fixed cells: determination of protein expression, localization, activity state, and the possibility for combination of fluorescent light microscopy with electron microscopy. Small organic fluorescent dyes, nanocrystals ("quantum dots"), autofluorescent proteins, small genetic encoded tags that can be complexed with fluorochromes, and combinations of these probes are highlighted.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giepmans, Ben N G -- Adams, Stephen R -- Ellisman, Mark H -- Tsien, Roger Y -- GM 72033/GM/NIGMS NIH HHS/ -- NS27177/NS/NINDS NIH HHS/ -- RR04050/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2006 Apr 14;312(5771):217-24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16614209" target="_blank"〉PubMed〈/a〉
    Keywords: Diffusion ; Enzymes/metabolism ; Fluorescence ; Fluorescence Resonance Energy Transfer ; Fluorescent Antibody Technique ; *Fluorescent Dyes/chemistry ; Genetic Techniques ; Immunohistochemistry ; *Luminescent Proteins/chemistry/genetics ; Microscopy, Electron ; *Molecular Probe Techniques ; Protein Conformation ; Protein Transport ; Proteins/*analysis/chemistry/metabolism/*physiology ; *Quantum Dots
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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