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  • Articles  (80)
  • United States  (56)
  • Time Factors  (24)
  • American Association for the Advancement of Science (AAAS)  (80)
  • American Chemical Society
  • Wiley
  • 2015-2019
  • 1980-1984  (80)
  • 1925-1929
  • 1983  (80)
Collection
  • Articles  (80)
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (80)
  • American Chemical Society
  • Wiley
  • Springer  (1)
Years
  • 2015-2019
  • 1980-1984  (80)
  • 1925-1929
Year
  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Apr 8;220(4593):142, 144, 146.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828887" target="_blank"〉PubMed〈/a〉
    Keywords: Dental Caries/*prevention & control ; *Fluoridation ; Humans ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-25
    Description: An examination of the way in which the Environmental Protection Agency, Occupational Safety and Health Administration, and Consumer Product Safety Commission each responded to evidence of formaldehyde's carcinogenicity in animal systems reveals the interplay between politics and science policy in regulatory determinations. In some cases there were significant and unjustified departures from reasoned decision-making. Agency decisions not to take action deserve special attention by citizens, the Congress, and the judiciary to ensure that federal regulatory agencies take the necessary steps to protect the public from significant health, safety, and environmental risks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ashford, N A -- Ryan, C W -- Caldart, C C -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):894-900.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635664" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; Consumer Product Safety ; Environmental Exposure ; Formaldehyde/*adverse effects ; Jurisprudence ; *Public Policy ; United States ; United States Environmental Protection Agency ; United States Occupational Safety and Health Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Capron, Alexander M -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):414.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11644013" target="_blank"〉PubMed〈/a〉
    Keywords: Coercion ; Humans ; Mandatory Programs ; *Public Policy ; *Tissue Donors ; *Tissue and Organ Procurement ; United States ; Voluntary Programs
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charrow, R P -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857235" target="_blank"〉PubMed〈/a〉
    Keywords: Advertising as Topic/*legislation & jurisprudence ; Drug Industry ; *Drug Prescriptions ; Humans ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1983-11-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):483-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623085" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *National Institutes of Health (U.S.) ; Research Support as Topic/*legislation & jurisprudence ; United States
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-23
    Description: Three-month-old infants learned to activate an overhead crib mobile by operant footkicking and received a visual reminder of the event (a "reactivation treatment") 2 weeks later, after forgetting had occurred. Subsequent manifestation of the association was a monotonic increasing function of time since the reactivation treatment, and performance of infants tested 8 hours after the remainder was related to the time spent sleeping in the interim (r = 0.75). These data demonstrate that normal retrieval is time-dependent. Moreover, individual data suggest that retrieval may be continuous rather than discontinuous.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fagen, J W -- Rovee-Collier, C -- MH 32307/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1349-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658456" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Infant ; *Memory ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fawcett, S L -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):707.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6348943" target="_blank"〉PubMed〈/a〉
    Keywords: History, 19th Century ; History, 20th Century ; Research/*history ; *Research Support as Topic ; United States
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):625-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603019" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Jurisprudence ; Mice ; *Mice, Inbred BALB C ; Rats ; Rats, Inbred Lew ; Rats, Inbred Strains ; Research ; United States ; Wisconsin
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-03-11
    Description: The AAAS Annual Meeting will be held in Detroit on 26-31 May 1983. The inclusive dates were given incorrectly as 21-31 May in the heading of the Preliminary Program (25 Feb., p. 948). The large body of water shown to the south of Detroit on the cover of the issue of 25 February is Lake Erie. The cover legend stated incorrectly that it was Lake Huron.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldstein, C M -- New York, N.Y. -- Science. 1983 Mar 11;219(4589):1172.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828850" target="_blank"〉PubMed〈/a〉
    Keywords: *Information Systems ; United States
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-02-04
    Description: The number of transcripts of the cellular oncogene ras, which is homologous to the transforming gene of Harvey sarcoma virus, increases during liver regeneration in rats. The increase in these transcripts in liver polysomal polyadenylated RNA occurs at the time of activation of DNA synthesis during the regenerative process induced by partial hepatectomy or carbon tetrachloride injury. The number of ras transcripts returns to basal levels within 72 hours. These observations show that transcription of a cellular oncogene increases in a regulated way in a nonneoplastic growth process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goyette, M -- Petropoulos, C J -- Shank, P R -- Fausto, N -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):510-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Tetrachloride Poisoning ; DNA/biosynthesis ; Hepatectomy ; *Liver Regeneration ; Nucleic Acid Hybridization ; *Oncogenes ; RNA, Messenger/biosynthesis ; Rats ; Sarcoma Viruses, Murine/genetics ; Time Factors ; *Transcription, Genetic
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: Consistency of hand preference was examined in a longitudinal study of children between 18 and 42 months of age. Results showed a sex-specific relationship between hand consistency and intellectual development. Across a variety of intellectual abilities at all ages, females with consistency of handedness were precocious compared to females without such consistency. This relationship did not hold for males.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gottfried, A W -- Bathurst, K -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1074-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879205" target="_blank"〉PubMed〈/a〉
    Keywords: Child, Preschool ; Female ; *Functional Laterality ; Humans ; Infant ; *Intelligence ; Intelligence Tests ; Male ; Sex Factors ; Time Factors
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):908.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6227081" target="_blank"〉PubMed〈/a〉
    Keywords: *Abnormalities, Multiple ; Civil Rights ; *Disabled Persons ; Federal Government ; Female ; *Government Regulation ; Humans ; Infant, Newborn ; *Judicial Role ; *Jurisprudence ; United States ; *Withholding Treatment ; Department of Justice suit in November 1983 against the State University Hospital ; in Stony Brook, New York, to obtain the infant's medical records. Parents and ; physicians had decided against treatment for the severely handicapped newborn, ; but legal action was begun by right-to-life advocates to appoint a guardian for ; the child and to order surgery. The Department of Justice became involved after ; two New York courts ruled against the action ; the Department's intervention is ; based on Section 504 of the Rehabilitation Act, which forbids discrimination ; against the handicapped.
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  • 13
    Publication Date: 1983-12-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):994-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648520" target="_blank"〉PubMed〈/a〉
    Keywords: American Medical Association ; *Forensic Psychiatry ; Humans ; *Mental Disorders ; United States
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1269-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612339" target="_blank"〉PubMed〈/a〉
    Keywords: Child Advocacy/legislation & jurisprudence ; *Congenital Abnormalities ; Ethics Committees, Clinical ; Federal Government ; *Government Regulation ; Humans ; Infant, Newborn ; United States ; *United States Dept. of Health and Human Services ; Withholding Treatment ; the Department of Health and Human Services is preparing a second version of ; federal rules designed to ensure appropriate treatment of handicapped newborns ; with life-threatening but correctible conditions. While child advocacy groups ; support the regulations with some reservations about the intrusive style of ; enforcement, most medical organizations, led by the American Academy of ; Pediatrics, are strongly opposed. Both houses of Congress have become involved ; with the issue by proposing to include handicapped infants under the Child Abuse ; and Treatment Act.
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurwitz, H Jr -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1377.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828868" target="_blank"〉PubMed〈/a〉
    Keywords: *Housing ; Humans ; *Radiation ; United States ; United States Environmental Protection Agency
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-22
    Description: Because of the prospect of a serious decline in the nation's biomedical research capacity owing to diminished federal appropriations, temporary measures should be initiated promptly by the National Institutes of Health to preserve the stability of resources and diversity of research required for future productivity. It is recommended that the available funds be distributed in such a way as to permit some support for 50 percent of competing grant applications approved by the National Institutes of Health study sections. Measures proposed for consideration are a sliding scale for funding, a greater across-the-board reduction, a limit on support for an individual laboratory, and a review of indirect costs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mandel, H G -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):338-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867712" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.)/organization & administration ; *Research Support as Topic/economics ; United States
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):485-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623087" target="_blank"〉PubMed〈/a〉
    Keywords: Accidents, Occupational/*prevention & control ; *Agriculture ; *Dust ; *Edible Grain ; Humans ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
    Publication Date: 1983-12-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):998-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648521" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*epidemiology/transmission ; Africa, Central ; Blood ; Europe ; Female ; Haiti ; Homosexuality ; Humans ; Male ; Sarcoma, Kaposi/epidemiology ; United States
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-01-14
    Description: By means of visual stimnulus without temporal or spatial edges, we have achieved better isolation of chromatic signals at detection threshold than has been reported previously. Under various states of adaptation, the spectral sensitivity of the chromatic mechanism detecting middle- and long-wavelength lights corresponds with that deduced from suprathreshold red/green hue equilibriums.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thornton, J E -- Pugh, E N Jr -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):191-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849131" target="_blank"〉PubMed〈/a〉
    Keywords: Color Perception/*physiology ; Humans ; Spectrum Analysis ; Time Factors
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  • 20
    Publication Date: 1983-11-11
    Description: Endothelial cells from human blood vessels were cultured in vitro, with doubling times of 17 to 21 hours for 42 to 79 population doublings. Cloned human endothelial cell strains were established for the first time and had similar proliferative capacities. This vigorous cell growth was achieved by addition of heparin to culture medium containing reduced concentrations of endothelial cell growth factor. The routine cloning and long-term culture of human endothelial cells will facilitate studying the human endothelium in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thornton, S C -- Mueller, S N -- Levine, E M -- AG-00839/AG/NIA NIH HHS/ -- T32-CA-09171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):623-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635659" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Cells, Cultured ; Clone Cells/enzymology ; Endothelium/*cytology ; Growth Substances/pharmacology ; Heparin/*pharmacology ; Humans ; Time Factors
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  • 21
    Publication Date: 1983-08-19
    Description: After median nerve fibers to glabrous skin on the hands of monkeys were crushed and allowed to regenerate, normal topographical organization was recovered in the representation of the hand in primary somatosensory cortex. Similar recovery of normal cortical organization may underlie the sensory restoration that usually follows nerve crush injury in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wall, J T -- Felleman, D J -- Kaas, J H -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):771-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879175" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aotus trivirgatus/physiology ; Brain Mapping ; Hand/innervation ; *Nerve Crush ; *Nerve Regeneration ; Somatosensory Cortex/*physiology ; Time Factors
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-03-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, John -- New York, N.Y. -- Science. 1983 Mar 4;219(4588):1047-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643956" target="_blank"〉PubMed〈/a〉
    Keywords: *Delivery of Health Care ; Education, Medical ; El Salvador ; Financial Support ; Health Personnel ; *Human Rights ; Humans ; Organizational Policy ; Physicians ; Politics ; *Professional Misconduct ; Public Policy ; *Societies ; United States ; Violence ; Salvador in January as observers for the American Association for the Advancement ; of Science, the National Academy of Sciences, the New York Academy of Sciences, ; and the International League for Human Rights. Their findings paralleled those of ; an earlier delegation--"a virtually complete breakdown of the health system" and ; continuing violence against health professionals. A number of scientific ; organizations in the U.S. are reported to be exploring ways to channel private ; aid from health professionals and to protect the rights of patients and health ; personnel without antagonizing the government of El Salvador.
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-01
    Description: Faced with limited resources, the United States must set priorities for research to identify preventable causes of cancer. A quantitative approach to priority setting, based on principles of decision analysis and cost-effectiveness analysis, can offer guidance in this process. An illustrative application of such a model suggests that the National Institutes of Health-supported clinical trial of dietary beta-carotene offers a greater expected reduction in cancer mortality per research dollar than carcinogen bioassays of high-volume industrial chemicals such as p-dichlorobenzene. National research priorities should reflect the relative cost-effectiveness of such investments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinstein, M C -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):17-23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6407110" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Carcinogens ; Carotenoids/adverse effects ; Chlorobenzenes/adverse effects ; Cost-Benefit Analysis ; Costs and Cost Analysis ; Humans ; Neoplasms/economics/mortality/*prevention & control ; Policy Making ; United States ; beta Carotene
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-03
    Description: When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, V L -- Jones, P A -- 1-T32-CA09320/CA/NCI NIH HHS/ -- R01-GM30892/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1055-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844925" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; *Aging ; Animals ; Cell Division ; Cell Line ; Cricetinae ; Cytosine/analogs & derivatives/metabolism ; DNA/metabolism/*physiology ; Fibroblasts/metabolism ; Humans ; Mesocricetus ; Methylation ; Mice ; Time Factors
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-03-04
    Description: Amplitude modulation is a predominant temporal feature in many vocal signals. The leopard frog, Rana pipiens, has a class of neurons in the central auditory system that respond selectively to particular rates of amplitude modulation; these neurons can be characterized by a temporal tuning curve. Such selectivity is absent in the peripheral auditory system. This type of transformation may be fundamental in processing temporal information in the vertebrate sensory nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rose, G -- Capranica, R R -- NS-09244/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 4;219(4588):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6600522" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Communication ; Animals ; Auditory Pathways/*physiology ; Auditory Perception/*physiology ; Brain/physiology ; Rana pipiens/*physiology ; Time Factors
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  • 26
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sammons, J H -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1375-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828867" target="_blank"〉PubMed〈/a〉
    Keywords: *American Medical Association ; Humans ; Medical Laboratory Science/*standards ; United States
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: A climate of fear now dominates the discussion of environmental issues. The scientific community can help alleviate this fear by making a greater effort to explain to the public the uncertainties involved in estimates of risk. Current statutory mandates designed to protect public health both demand levels of protection that technology cannot achieve and are uncoordinated across government agencies. A common statutory framework for dealing with environmental risks is needed. In addition, care must be taken to separate the scientific process of assessing risk from the use of such assessments, together with economic and policy considerations, in the management of risks through regulatory action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruckelshaus, W D -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879200" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Pollutants ; International Cooperation ; Legislation as Topic ; *Public Policy ; Risk ; *Science ; United States ; United States Environmental Protection Agency
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  • 28
    Publication Date: 1983-09-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1157-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612327" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Industry ; Evaluation Studies as Topic ; Patents as Topic ; Research ; United States
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  • 29
    Publication Date: 1983-01-07
    Description: After administration of tyrosine, total concentration of biopterin, the cofactor for tyrosine hydroxylase, was increased in the striatum, adrenal glands, and serum of rats, and in the serum of humans. Serum biopterin is lower in patients with Parkinson's disease than in normal controls. After oral administration of tyrosine, the increase in serum biopterin concentration was smaller in patients with Parkinson's disease (less than twofold) than in healthy controls (three-to sevenfold). These results suggest that tyrosine may have a regulatory role in biopterin biosynthesis and that patients with Parkinson's disease may have some abnormality in the regulation of biopterin biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamaguchi, T -- Nagatsu, T -- Sugimoto, T -- Matsuura, S -- Kondo, T -- Iizuka, R -- Narabayashi, H -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849120" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Adrenal Glands/metabolism ; Alanine/pharmacology ; Animals ; Biopterin/*blood ; Corpus Striatum/metabolism ; Humans ; Injections, Intraperitoneal ; Liver/metabolism ; Male ; Parkinson Disease/*blood ; Pteridines/*blood ; Rats ; Rats, Inbred Strains ; Time Factors ; Tyrosine/administration & dosage/*pharmacology
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  • 30
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-16
    Description: The mouse neuroblastoma-rat glioma hybrid cell line NG108-15 was used to study the acute and chronic interaction of ethanol with intact neural cells. In the short term, ethanol inhibited opiate receptor binding, but after long-term exposure the cells exhibited an apparent adaptive increase in the number of opiate binding sites; this was reversible when ethanol was withdrawn. High concentrations of ethanol (200 mM) increased opiate binding after 18 to 24 hours, whereas lower concentrations (25 to 50 mM) produced similar changes after 2 weeks. This model system has potential for exploring the cellular and molecular mechanisms underlying ethanol intoxication, tolerance, and withdrawal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charness, M E -- Gordon, A S -- Diamond, I -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1246-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316506" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Dose-Response Relationship, Drug ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Ethanol/*pharmacology ; Glioma ; Hybrid Cells ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Rats ; Receptors, Opioid/*drug effects/metabolism ; Time Factors
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):31-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828878" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; Federal Government ; *Fraud ; *National Institutes of Health (U.S.) ; Research ; Schools, Medical ; United States ; Medical School, from the first known act of fraud to recent evidence that ; implicates Darsee's earlier work at Emory University and Notre Dame. Darsee's ; Harvard data were eventually re-examined both by Harvard and by a panel appointed ; by the National Heart, Lung, and Blood Institute (NHLBI), which had funded much ; of his research. The NHLBI findings, which were reviewed by senior staff at the ; National Institutes of Health, faulted the supervisory practices of Darsee's ; mentor, Dr. Eugene Braunwald. Braunwald acknowledges the need for change but ; believes that his pattern of supervision is common to many laboratories.
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-02-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):470-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6687409" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.)/*organization & administration ; Research Support as Topic ; Training Support ; United States
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  • 33
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, B D -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1381.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6572417" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Behavior Control ; *Ethics, Medical ; *Genetic Engineering ; Humans ; Religion ; United States
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  • 34
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-01-28
    Description: Human simple reaction times and magnitude estimates of taste intensity increased as the duration of 500-millimolar sodium chloride or 2-millimolar saccharin sodium pulses lengthened from 100 to 1000 milliseconds. Responses to "What was the taste?" ranged from 94 to 100 percent "sweet" for saccharin and 68 to 83 percent "salty" for salt across all pulse durations when both substances were randomized with water pulses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelling, S T -- Halpern, B P -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):412-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849142" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Saccharin ; Sodium Chloride ; Taste/*physiology ; Time Factors
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  • 35
    Publication Date: 1983-08-26
    Description: Anti-idiotype reagents that recognize a common idiotype associated with the combining site of antibodies to hepatitis B surface antigen (anti-HBs) were used to manipulate the immune response to hepatitis B surface antigen in BALB/c mice. The injection of antibodies to the idiotype before antigenic stimulation resulted in an increase in the number of cells secreting immunoglobulin M antibodies to hepatitis B surface antigen. Anti-HBs-secreting cells were also induced by administration of antibodies to the idiotype without subsequent antigen exposure. These findings indicate that the immune response to hepatitis B surface antigen in mice is regulated through an idiotype-anti-idiotype network.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, R C -- Adler-Storthz, K -- Henkel, R D -- Sanchez, Y -- Melnick, J L -- Dreesman, G R -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):853-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603657" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Anti-Idiotypic/immunology ; Antibodies, Viral/*biosynthesis ; Hepatitis B Antibodies/*biosynthesis ; Hepatitis B Surface Antigens/*immunology ; Immunoglobulin G/biosynthesis ; Immunoglobulin Idiotypes/immunology ; Immunoglobulin M/biosynthesis ; Mice ; Spleen/immunology ; Time Factors
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):36-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828879" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; Dioxins/adverse effects ; *Government Agencies ; Humans ; Policy Making ; Trichloroethylene/adverse effects ; United States ; *United States Environmental Protection Agency
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  • 37
    Publication Date: 1983-01-07
    Description: The immediate induction of the full complement of maternal behavior in nonpregnant ewes primed with estrogen and progesterone has been obtained after 5 minutes of vaginal-cervical stimulation. A similar period of such stimulation given to recently parturient ewes, after the development of selective bonding to their own lambs, reversed their rejection behavior of alien lambs and produced a state of plasticity in maternal behavior, such that ewes receiving vaginal stimulation would accept and adopt alien lambs. These findings implicate vaginal-cervical stimulation as playing a role in the onset of maternal behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keverne, E B -- Levy, F -- Poindron, P -- Lindsay, D R -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):81-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849123" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/pharmacology ; Female ; *Maternal Behavior ; Pregnancy ; Progesterone/pharmacology ; Sheep/*physiology ; Time Factors ; Vagina/*physiology
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-29
    Description: Compared to nonpregnant controls, pregnant mice injected with phenobarbital had lower concentrations of the drug in the plasma but equivalent concentrations in the brain. In spite of the similar concentrations in the brain, the behavioral response to phenobarbital was greater for pregnant than nonpregnant mice. These results suggest that the concentration of phenobarbital in the plasma, which is commonly used as a basis for adjusting phenobarbital dosage during pregnancy, is not an appropriate indicator of the dynamics of the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Middaugh, L D -- Zemp, J W -- Boggan, W O -- AA03532/AA/NIAAA NIH HHS/ -- DA00041/DA/NIDA NIH HHS/ -- DA01750/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):534-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836299" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Chemistry ; Dose-Response Relationship, Drug ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Motor Activity/drug effects ; Phenobarbital/analysis/*metabolism/pharmacology ; *Pregnancy/drug effects ; Time Factors
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  • 39
    Publication Date: 1983-10-14
    Description: The transport of specific proteins in regenerating optic fibers of goldfish depends on the presence or absence of the optic tectum. When optic fibers were allowed to contact the tectum, amounts of rapidly transported proteins having molecular weights between 120,000 and 160,000 increased, and a species of molecular weight 26,000 reverted to normal levels. When nerves were prevented from contacting the tectum, the amount of the 26,000-molecular weight protein remained high for months. Amounts of other transported proteins, in particular a group of acidic components of molecular weight 44,000 to 49,000 that increase greatly at early stages of regeneration, proved to be independent of the tectum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benowitz, L I -- Yoon, M G -- Lewis, E R -- R01NS16943/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):185-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6194562" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axonal Transport ; Biological Transport ; Cell Communication ; Goldfish ; Isoelectric Point ; Molecular Weight ; *Nerve Regeneration ; Nerve Tissue Proteins/*metabolism ; Superior Colliculi/*physiology ; Time Factors ; Visual Pathways/*physiology
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  • 40
    Publication Date: 1983-06-10
    Description: Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergmann, S R -- Fox, K A -- Ter-Pogossian, M M -- Sobel, B E -- Collen, D -- HL 17646/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6602378" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coronary Disease/*drug therapy/radionuclide imaging ; Dogs ; Fibrinogen/analysis ; Infusions, Parenteral ; Injections ; Plasminogen Activators/administration & dosage/*therapeutic use ; Streptokinase/administration & dosage/therapeutic use ; Time Factors ; Tomography, Emission-Computed
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  • 41
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cairns, J -- Boyle, D -- Frei, E 3rd -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):252, 254, 256.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836271" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Antineoplastic Agents/*therapeutic use ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Leukemia/drug therapy/mortality ; Male ; Neoplasms/*drug therapy/mortality ; United States
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-01-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frumin, E -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):340.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6687371" target="_blank"〉PubMed〈/a〉
    Keywords: *Dust ; Environmental Exposure ; Gossypium ; United States ; United States Occupational Safety and Health Administration
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-10-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jonides, J -- Irwin, D E -- Yantis, S -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):188.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623072" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Research Design ; Time Factors ; Visual Perception/*physiology
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  • 44
    Publication Date: 1983-10-14
    Description: Two-month-old infants discriminated complex sinusoidal patterns that varied in the duration of their initial frequency transitions. Discrimination of these nonspeech sinusoidal patterns was a function of both the duration of the transitions and the total duration of the stimulus pattern. This contextual effect was observed even though the information specifying stimulus duration occurred after the transitional information. These findings parallel those observed with infants for perception of synthetic speech stimuli. Specialized speech processing capacities are thus not required to account for infants' sensitivity to contextual effects in acoustic signals, whether speech or nonspeech.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jusczyk, P W -- Pisoni, D B -- Reed, M A -- Fernald, A -- Myers, M -- HD-11915/HD/NICHD NIH HHS/ -- HD-15795-02/HD/NICHD NIH HHS/ -- MH-24027/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):175-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623067" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Infant ; Speech Perception/*physiology ; Time Factors
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  • 45
    Publication Date: 1983-11-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):906-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6688887" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Humans ; *Intelligence ; Lead/analysis ; Lead Poisoning/*complications ; Tooth/analysis ; United States ; United States Environmental Protection Agency
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  • 46
    Publication Date: 1983-08-05
    Description: Synaptic contacts per unit area in the rat dentate gyrus reach adult numbers by the end of the first month after birth and remain constant thereafter. This experiment demonstrated that the rate at which synapses were replaced by sprouting after a lesion declined dramatically from 35 to 90 days of age. Thus, the juvenile period of the rat's life is marked by a considerable change in neuronal plasticity. This may be related to age-dependent effects in recovery from brain damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McWilliams, J R -- Lynch, G -- 5 F32 NS06821/NS/NINDS NIH HHS/ -- AG00538-06/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):572-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867730" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Axons/physiology ; Denervation ; Hippocampus/*physiology ; Male ; Nerve Degeneration ; Neuronal Plasticity ; Rats ; Synapses/*physiology ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-08
    Description: Rearing cats in the dark extends the critical period for development of visual cortical neurons, which indicates that the experience of visual input is necessary to begin the developmental process. A single brief pulse of visual input (6 hours) during a period of dark-rearing eliminates delayed development in the visual cortex. Light therefore seems to rapidly trigger the developmental process, and once triggered, that process runs to completion in the absence of further input.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mower, G D -- Christen, W G -- Caplan, C J -- EY 03335/EY/NEI NIH HHS/ -- HD 06276/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857278" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Darkness ; *Neuronal Plasticity ; Time Factors ; Vision, Ocular/physiology ; Visual Cortex/growth & development/*physiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):436, 438.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867719" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; Female ; Humans ; Male ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6344219" target="_blank"〉PubMed〈/a〉
    Keywords: Costs and Cost Analysis ; Humans ; *Liver Transplantation ; National Institutes of Health (U.S.) ; Patient Selection ; Tissue and Organ Procurement ; United States ; Liver Transplantation has concluded that, with some exceptions, transplantation ; could be considered for most patients who are near death with liver disease. This ; recommendation comes despite problems in interpreting existing data on survival ; rates. The panel did not address the issues of who should pay for liver ; transplants, or of how many donor livers would be needed if more transplantation ; centers were established.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):32-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857260" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Death ; Female ; Humans ; Male ; Mandatory Programs ; Middle Aged ; Tissue Donors ; *Tissue and Organ Procurement ; *Transplantation ; United States ; tissue are revolutionizing organ transplantation, but the current shortage of ; donated organs is expected to worsen. The reasons for this shortage and possible ; solutions to the problem are discussed briefly, and the ethical and legal ; implications of salvaging organs from brain-dead patients are mentioned. Presumed ; consent laws, already in force in several European countries, would drastically ; increase the number of available organs, but American ethicists are divided over ; a policy permitting automatic use of organs unless a person has left explicit ; instructions to the contrary.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):387-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836280" target="_blank"〉PubMed〈/a〉
    Keywords: *Advertising as Topic/legislation & jurisprudence ; Drug Prescriptions ; Federal Government ; *Government Regulation ; Humans ; Information Dissemination ; *Pharmaceutical Preparations ; Risk Assessment ; United States ; *United States Food and Drug Administration ; companies would like to be allowed to advertise their prescription drugs to the ; general public as well as to health professionals. The Food and Drug ; Administration, concerned about the legal and ethical implications of ; direct-to-consumer advertising, has asked for time to study the proposal.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1983 May 6;220(4597):591.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836302" target="_blank"〉PubMed〈/a〉
    Keywords: Cerebrovascular Disorders/*epidemiology/prevention & control ; Humans ; Hypertension/prevention & control ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-02-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1983 Feb 11;219(4585):747-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823551" target="_blank"〉PubMed〈/a〉
    Keywords: *Research Support as Topic ; United States
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  • 54
    Publication Date: 1983-04-15
    Description: Perceptual sensitivity to a visual target presented in a random continuous sequence of targets and nontargets decreased rapidly over time when stimuli were highly degraded visually but not when moderately degraded or undegraded. Large declines in sensitivity, independent of changes in response criterion, were found after only 5 minutes of observation. These rapid decrements of sensitivity to degraded targets seem to result from demands on the limited capacity of visual attention.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nuechterlein, K H -- Parasuraman, R -- Jiang, Q -- 784040-29867-5/PHS HHS/ -- MH 30911/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):327-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836276" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Attention ; Child ; Discrimination (Psychology) ; Female ; Humans ; Male ; Memory ; Time Factors ; *Visual Perception
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-19
    Description: Ground water contamination is of increasing concern in the United States because about 50 percent of our drinking water comes from well water. The causes of contamination stem from both point sources and nonpoint sources. Since ground water moves slowly, the contaminant may affect only a small portion of an aquifer for a considerable period of time. Deleterious effects on human health have resulted from pathogenic organisms in ground water and from its toxic chemical composition. It is difficult to estimate the extent of contamination on a national basis as the frequency of instances of contamination is very variable. Remedial actions to clean up aquifers are difficult, expensive, and sometimes not feasible. Many of the laws and regulations that control ground water contamination are designed with other main objectives.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pye, V I -- Patrick, R -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):713-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879171" target="_blank"〉PubMed〈/a〉
    Keywords: Ecology ; United States ; United States Environmental Protection Agency ; Water Pollution/*analysis
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  • 56
    Publication Date: 1983-07-08
    Description: The issue of whether sleep is physiologically necessary has been unresolved because experiments that reported deleterious effects of sleep deprivation did not control for the stimuli used to prevent sleep. In this experiment, however, experimental and control rats received the same relatively mild physical stimuli, but stimulus presentations were timed to reduce sleep severely in experimental rats but not in controls. Experimental rats suffered severe pathology and death; control rats did not.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rechtschaffen, A -- Gilliland, M A -- Bergmann, B M -- Winter, J B -- MH-18428/MH/NIMH NIH HHS/ -- MH-4151/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):182-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857280" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/pathology ; Animals ; Body Weight ; Electroencephalography ; Male ; Organ Size ; Rats ; Rats, Inbred Strains ; Sleep Deprivation/*physiology ; Time Factors
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  • 57
    Publication Date: 1983-04-15
    Description: Human mononuclear leukocytes were exposed to microwaves at energies relevant to current public safety recommendations. No detectable effects on viability or function of the leukocytes resulted from exposure to microwaves at specific absorption rates up to 4 milliwatts per milliliter. The results were highly reproducible and provided no evidence that current safety standard recommendations are inappropriate insofar as leukocyte function is concerned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, N J Jr -- Lu, S T -- Michaelson, S M -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):318-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6188214" target="_blank"〉PubMed〈/a〉
    Keywords: DNA/biosynthesis ; Environmental Exposure ; Humans ; Leukocytes/*radiation effects ; Maximum Allowable Concentration ; Protein Biosynthesis ; RNA/biosynthesis ; Radio Waves/*adverse effects ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-02-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Feb 18;219(4586):794, 796, 798.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823552" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; United States ; United States Environmental Protection Agency
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  • 59
    Publication Date: 1983-05-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barlow, D H -- Bellack, A S -- Buchwald, A M -- Garfield, S L -- Hartmann, D P -- Herman, C P -- Hersen, M -- Miller, P M -- Rachman, S -- Wolpe, J -- New York, N.Y. -- Science. 1983 May 6;220(4597):554, 556.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836301" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholism/*therapy ; *Behavioral Research ; Canada ; *Editorial Policies ; *Ethics, Medical ; Humans ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-02
    Description: Almost 40,000 selected seventh-grade students from the Middle Atlantic region of the United States took the College Board Scholastic Aptitude Test as part of the Johns Hopkins regional talent search in 1980, 1981, and 1982. A separate nationwide talent search was conducted in which any student under age 13 who was willing to take the test was eligible. The results obtained by both procedures establish that by age 13 a large sex difference in mathematical reasoning ability exists and that it is especially pronounced at the high end of the distribution: among students who scored greater than or equal to 700, boys outnumbered girls 13 to 1. Some hypothesized explanations of such differences were not supported by the data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benbow, C P -- Stanley, J C -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):1029-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648516" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Cognition ; Female ; Humans ; Male ; *Mathematics ; Sex Factors ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):479-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836291" target="_blank"〉PubMed〈/a〉
    Keywords: Congenital Abnormalities/therapy ; *Euthanasia ; Federal Government ; *Government Regulation ; Humans ; Infant, Newborn ; Judicial Role ; Parental Consent ; United States ; *United States Dept. of Health and Human Services ; *Withholding Treatment ; as "arbitrary and capricious," a Department of Health and Human Services ; regulation that required hospitals to post notices concerning the illegality of ; denying life-saving care to handicapped infants and encouraged anyone with ; knowledge of such a case to report it to HHS via a telephone hotline. This ; article reviews the evolution and implementation of the HHS regulation, the legal ; challenge to it, and the judge's ruling.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):929-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879191" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; *Research Support as Topic ; United States ; Universities/economics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1310-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658453" target="_blank"〉PubMed〈/a〉
    Keywords: *Legislation, Nursing ; *National Institutes of Health (U.S.) ; *Nursing ; Research ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 Jul 15;221(4607):243-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857283" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *National Institutes of Health (U.S.)/organization & administration ; Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1983 May 27;220(4600):936.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844919" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; *Fraud ; Georgia ; Humans ; National Institutes of Health (U.S.) ; Research ; United States ; he was appointed a fellow at the Harvard Medical School, has revealed fabrication ; of data, unauthorized use of co-authors' names, and fictitious collaborators. The ; Emory investigation was undertaken after Harvard notified Emory of its suspicion ; of Darsee's Harvard research. Emory's investigative report focused only on the ; extent of Darsee's data fabrication. A copy of the report was sent immediately to ; the National Institutes of Health, but the university was reluctant to send it to ; medical licensing boards or to the hospital where Darsee is currently employed.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-04-01
    Description: By means of a two-stage promotion protocol in mouse epidermis with 12-O-tetradecanoylphorbol-13-acetate as first-stage promoter and 12-O-retinoylphorbol-13-acetate as second-stage promoter, the effects of the former that are critical and obligatory for tumor promotion were shown to be irreversible in nature for at least 8 weeks. The reversibility of tumor promotion was related to the second stage of promotion, reflecting the reversibility of epidermal hyperplasia induced by 12-O-tetradecanoylphorbol-13-acetate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Furstenberger, G -- Sorg, B -- Marks, F -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828884" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens/*pharmacology ; Cell Line ; Epidermis/drug effects ; Female ; Hyperplasia/chemically induced ; Mice ; Mice, Inbred Strains ; Neoplasms, Experimental/chemically induced ; Phorbol Esters/*adverse effects ; Phorbols/*adverse effects ; Precancerous Conditions/chemically induced ; Skin Neoplasms/*chemically induced ; Tetradecanoylphorbol Acetate/*adverse effects ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1130-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857237" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Crime ; *Fraud ; Illinois ; Mice ; Pesticides/toxicity ; Rats ; *Toxicology ; United States ; United States Environmental Protection Agency
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-02-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):469.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6687408" target="_blank"〉PubMed〈/a〉
    Keywords: Bioethical Issues ; Ethics ; *Federal Government ; *Infant Food ; *National Institutes of Health (U.S.) ; United States ; discussion of a dispute on the marketing of infant formula from a symposium on ; bioethics because of protests by the Nestle Company. NIH administrators deny that ; censorship was the reason for the cancellation.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1360-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6574603" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Cell Line ; *Ethics, Medical ; Federal Government ; Genetic Diseases, Inborn/therapy ; *Genetic Engineering ; *Germ Cells ; *Government Regulation ; Human Characteristics ; Humans ; Risk Assessment ; United States ; cells has been signed by leaders of almost every major church group in the United ; States. Some of the religious leaders, while not certain that a total moratorium ; should be placed on altering germline cells, signed the statement in order to ; stimulate public debate on the issue. Legislation has recently been introduced in ; Congress to set up a committee to monitor genetic engineering and its human ; applications, but author Jeremy Rifkin, the impetus behind the church leaders' ; resolution, argues that such tampering threatens the gene pool and should be ; banned altogether.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):484.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623086" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *National Institutes of Health (U.S.) ; Research Support as Topic/*legislation & jurisprudence ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 71
    Publication Date: 1983-12-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):992-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648519" target="_blank"〉PubMed〈/a〉
    Keywords: *Legislation, Medical ; *National Institutes of Health (U.S.)/organization & administration ; Research ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):633.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6408737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; Dogs ; Goats ; Haplorhini ; *Legislation as Topic ; National Institutes of Health (U.S.) ; Swine ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Jul 29;221(4609):440-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867721" target="_blank"〉PubMed〈/a〉
    Keywords: Federal Government ; Female ; *Government Regulation ; Humans ; Neural Tube Defects/*diagnosis ; Pregnancy ; Pregnant Women ; *Prenatal Diagnosis/instrumentation ; Risk Assessment ; United States ; United States Food and Drug Administration ; Administration on 17 June to approve the wider use of diagnostic kits for the ; detection of fetal neural tube defects. The American College of Obstetricians and ; Gynecologists and the American Academy of Pediatrics are among the critics who ; favor tighter restrictions on use of the kits, which measure levels of ; alpha-fetoprotein in serum samples taken from expectant mothers, on the grounds ; that false positive results are common, necessitating careful quality control ; monitoring of physicians, manufacturers, and laboratories performing the test.
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1407.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828869" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; *Politics ; Research Support as Topic ; *Science ; United States
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-01-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):37-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849113" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; *Health Policy ; United States ; country without any comprehensive, nonpartisan forum for assessing the safety and ; cost effectiveness of biomedical technologies. While many private and public ; groups found the Center's evaluations useful, the American Medical Association ; and the Health Industry Manufacturers Association viewed it as a regulatory ; agency and lobbied for its closure. Despite the efforts of various medical ; societies, insurers, and the medical device industry to establish their own ; review programs, many policy analysts would like to see a federal panel revived.
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  • 76
    Publication Date: 1983-05-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1983 May 20;220(4599):804-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844916" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/*psychology ; Child ; Humans ; National Institute of Mental Health (U.S.) ; *Television ; United States ; *Violence
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  • 77
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1309.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6581535" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA, Recombinant ; Genetic Engineering/*methods ; *Patents as Topic ; United States ; powerful gene-splicing technique to Biogen, whose chairman, Walter Gilbert, ; developed the process while at the university. Although Biogen has invested ; heavily in the gene-splicing technique and is confident it will replace or ; successfully compete with methods currently used to manufacture human insulin and ; other proteins, some experts question whether Gilbert's process is commercially ; feasible.
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-11-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):593-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635657" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Industry ; Legislation as Topic ; *Patents as Topic ; United States
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-12-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1983 Dec 2;222(4627):990-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6359415" target="_blank"〉PubMed〈/a〉
    Keywords: *Foundations ; History, 20th Century ; Research Support as Topic ; *Science ; United States
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  • 80
    Publication Date: 1983-09-09
    Description: Prolonged treatment with classical antipsychotic drugs decreased the number of spontaneously active dopamine neurons in both the substantia nigra (A9) and the ventral tegmental area (A10) of the rat brain. In contrast, treatment with atypical antipsychotic drugs selectively decreased the number of A10 dopamine neurons. Related drugs lacking antipsychotic efficacy failed to decrease dopamine activity. These findings suggest that the inability of atypical antipsychotic drugs to decrease A9 dopamine neuronal activity may be related to their lower potential for causing tardive dyskinesia and that the inactivation of A10 neurons may be involved in the delayed onset of therapeutic effects during treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, F J -- Wang, R Y -- MH 00378/MH/NIMH NIH HHS/ -- MH-34424/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1054-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6136093" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antipsychotic Agents/*pharmacology ; Dopamine/*metabolism ; Male ; Metoclopramide/pharmacology ; Mice ; Neurons/metabolism ; Pons/*metabolism ; Rats ; Rats, Inbred Strains ; Substantia Nigra/*metabolism ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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