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  • hypertension  (19)
  • Chromatographie, Gas  (17)
  • Analytical Chemistry and Spectroscopy
  • Chemistry
  • Springer  (38)
  • 1980-1984  (38)
  • 1925-1929
  • 1980  (38)
Collection
Keywords
Publisher
Years
  • 1980-1984  (38)
  • 1925-1929
Year
  • 1
    Electronic Resource
    Electronic Resource
    Interstellar molecules (1980)
    Springer
    Journal of molecular evolution 15 (1980), S. 79-101 
    Details
    ISSN: 1432-1432
    Keywords: Molecules ; Interstellar ; Chemistry ; Isotopes ; Solar system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The study of interstellar molecules broadly includes two areas of interest. One area uses the unique ability of molecules to act as probes of the physical conditions in the cold, dense, visually opaque component of the interstellar medium. The physical properties of this and other components of the interstellar medium are summarized. The other area deals with the chemistry of interstellar molecules, recent aspects of which are emphasized in this review. Gas-phase chemistry, shock chemistry, and grain surface chemistry are discussed in the context of recent observations. No present observations suggest that surface reactions are relevant, but neither can they be ruled out. Ion-molecule reactions are clearly operative, at least for the simpler species. Chemical isotope fractionation is reviewed, andd it is concluded that the complexities of the chemistry allow no cosmological conclusions to be drawn from observations of deuterium in interstellar molecules, while the presence of13C in interstellar molecules permits an estimate of the12C/13C ratio which is consistent with the current concepts of the nucleosynthesis history of the Galaxy. Possible connections between interstellar molecules and the early molecular history of the solar system are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732663
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  • 2
    Electronic Resource
    Electronic Resource
    The importance of energetic particle precipitation on the chemical composition of the middle atmosphere (1980)
    Springer
    Pure and applied geophysics 118 (1980), S. 128-151 
    Details
    ISSN: 1420-9136
    Keywords: Galactic cosmic rays ; Solar proton events ; Particle precipitation ; Chemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract An assessment is made of the relative contribution of certain classes of energetic particle precipitation to the chemical composition of the middle atmosphere with emphasis placed on the production of odd nitrogen and odd hydrogen species and their subsequent role in the catalytic removal of ozone. Galactic cosmic radiation is an important source of odd nitrogen in the lower stratosphere but since the peak energy deposition occurs below the region where catalytic removal of O3 is most effective, it is questionable whether this mechanism is important in the overall terrestrial ozone budget. The precipitation of energetic solar protons can periodically produce dramatic enhancement in upper stratospheric NO. The long residence time of NO in this region of the atmosphere, where catalytic interaction with O3 is also most effective, mandates that this mechanism be included in future modelling of the global distribution of O3. Throughout the mesosphere the precipitation of energetic electrons from the outer radiation belt (60°≲Λ≲70°) can sporadically act as a major local source of odd hydrogen and odd nitrogen leading to observable O3 depletion. Future satellite studies should be directed at simultaneously measuring the precipitation flux and the concomitant atmosphere modification, and these results should be employed to develop more sophisticated models of this important coupling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01586448
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of sotalol after chronic administration to patients with renal insufficiency (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 321-326 
    Details
    ISSN: 1432-1041
    Keywords: sotalol ; hypertension ; renal impairment ; chronic administration ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten hypertensive patients with moderate to severe impairment of renal function were treated with sotalol for 5 to 10 weeks (average 6.4 weeks). Dosage was individually titrated (range 80 to 480 mg daily). The drug was given once daily in the morning. In eight patients blood pressure was satisfactorily controlled. Higher steady-state levels were observed than have been reported after similar doses in patients with normal renal function. The apparent first-order elimination rate constant and plasma clearance were significantly correlated with glomerular filtration rate. For an anuric patient, serum half-life was calculated to be 69 h. In relation to the raised plasma levels, side effects were uncommon. Since sotalol is excreted predominantly via the kidney, therapy in patients with impaired renal function should start with a low dose and any increase in dosage should be made carefully. As the anti-hypertensive effect does not appear to be correlated with the plasma level or with tolerance, adjustment of dose should be based on clinical response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561389
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  • 4
    Electronic Resource
    Electronic Resource
    Maximal exercise power after a single dose of metoprolol and of slow-release metoprolol (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 225-229 
    Details
    ISSN: 1432-1041
    Keywords: metoprolol ; hypertension ; slow-release preparations ; maximal exercise power ; fatigue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The treatment of hypertension with a single daily-dose of a beta-blocker gives rise to high peak-plasma concentrations 1.5 h after ingestion. After slow release-preparations of beta-blockers, the peak concentrations are half those produced by the conventional preparation at the same oral dose. A frequently occurring side-effect of beta-blocker therapy is fatigue. In this study the effect of a single dose of metoprolol 300 mg, 200 mg, 200 mg slow-release and a placebo on maximal exercise power was tested in 6 healthy subjects, 1.5 h and 24 h after ingestion. Maximal exercise power was significantly reduced 1.5 h after ingestion of metoprolol 300 mg and 200 mg. No change was found 1.5 h after 200 mg of a slow-release preparation. The possible reasons for reduced maximal exercise power are discussed. It is concluded that use of a beta-blocker for the treatment of hypertension in a single daily-dose regimen may be a reason to prefer a slow-release preparation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563003
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  • 5
    Electronic Resource
    Electronic Resource
    Monoamine metabolites in cerebrospinal fluid during treatment of hypertension with prazosin (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 399-401 
    Details
    ISSN: 1432-1041
    Keywords: prazosin ; hypertension ; central monoaminergic neurons ; monoamine metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six hypertensive patients were treated with prazosin up to a final dose of 3–4.5 mg/day. There was a significant reduction of blood pressure. The cerebrospinal fluid (CSF) concentrations of the major metabolites of noradrenaline, dopamine and serotonin were unchanged. This indicates that the antihypertensive effect is not mediated via central monoaminergic neurons as suggested by animal studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00636792
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  • 6
    Electronic Resource
    Electronic Resource
    Renin-angiotensin-aldosterone system (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 105-108 
    Details
    ISSN: 1432-1041
    Keywords: renin ; angiotensin ; aldosterone ; hypertension ; hypoaldosteronism ; pseudohypoaldosteronism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary There is increased activity of the renin, angiotensin, aldosterone (RAA) system in infancy and childhood. An inverse relationship between plasma renin, aldosterone and age has been demonstrated. In childhood hypertension due to renovascular disease or pyelonephritic scarring peripheral plasma renin is increased. Renal vein renin measurements in children with renal hypertension have proved valuable in predicting surgical curability of the underlying lesion. The upper limit of normal for the renal venous renin ratio in normotensive children without renal disease is 1.5. Pharmacological blockade of the RAA system has a place in diagnosis and treatment of hypertensive children. The plasma renin aldosterone profile is diagnostically useful in the investigation of salt-wasting disease and can easily distinguish between aldosterone biosynthetic defects and pseudohypoaldosteronism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561486
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  • 7
    Electronic Resource
    Electronic Resource
    Comparison of the effects of propranolol and labetalol on renal haemodynamics at rest and during exercise in essential hypertension (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 135-139 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; labetalol ; propranolol ; renal haemodynamics ; glomerular filtration rate ; blood pressure ; exercise ; renal blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of exercise on renal haemodynamics was examined in young patients with mild essential hypertension. Four groups of subjects were studied: 13 normotensive, healthy control subjects, and 15 untreated, 11 propranolol-treated, and 6 labetalol-treated patients. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were measured during four consecutive periods, a pre-exercise control period, two exercise periods with loads of 450 kpm/min and 600 kpm/min, respectively, and a post-exercise control period. In the untreated patients RPF and GFR were lower during exercise than in the normotensive control subjects, whereas no significant differences were found at rest. In the propranolol-treated patients the reduction in RPF and GFR during exercise was more pronounced than in the untreated hypertensives. In the labetalol-treated patients however, RPF and GFR were reduced only to the same degree as in the untreated hypertensives. The reduced renal blood flow in propranolol-treated patients may be attributed to a compensatory increase in sympathetic activity caused by an impaired cardiac response to exercise. The lack of reduction in renal blood flow during labetalol therapy could partly be related to alpha-adrenergic blockade in the renal vascular bed induced by labetalol, and partly to the smaller reduction in cardiac output during labetalol than during propranolol therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561580
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  • 8
    Electronic Resource
    Electronic Resource
    Double-blind controlled trial of molsidomine in hypertension (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 231-235 
    Details
    ISSN: 1432-1041
    Keywords: molsidomine ; hypertension ; hypotension ; angina pectoris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Molsidomine (M), a new long-lasting antianginal compound, was studied in 38 hypertensive patients to assess its antihypertensive properties. Six patients were selected for an acute, single dose comparative trial with placebo over 8 h after treatment. The remaining 32 patients were used in a 1 month trial to study the effect on BP of more prolonged treatment. Systolic, diastolic and mean BP were significantly reduced after a single dose of M 4 mg, and the effect lasted for about 8 h. M also inhibited the hypertensive response to isometric exercise in handgrip tests performed 1 and 8 h after M ingestion. A dose-related decrease in systolic and diastolic BP in the one month trial was also observed. In addition to its antianginal properties, M appears to possess an interesting effect on BP in mildly to moderately hypertensive patients. A fall in BP is also a valuable effect in coronary patients with augmented metabolic demands of the heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563004
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  • 9
    Electronic Resource
    Electronic Resource
    Relationship between the antihypertensive effect and steady-state plasma concentration of nifedipine given alone or in combination with a beta-adrenoceptor blocking agent (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 287-293 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; nifedipine ; beta-adrenoceptor blockade ; hypotensive action ; adverse effects ; combination therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antihypertensive effect of nifedipine (10–20 mg t.i.d.) given alone, or in combination with a beta-adrenoceptor blocking drug, was related to the observed plasma concentration during one dosage interval at steady-state (Pl-Nifss). The study was carried out as a within-patient comparison of treatment with nifedipine or placebo for 4 weeks. A highly significant reduction in blood pressure was obtained during monotherapy, as well as during combined treatment. The blood pressure reduction when nifedipine was added to beta-adrenoceptor blockade was of the same magnitude as that observed on nifedipine monotherapy. A considerable variation in Pl-Nifss was noted (range: 2–70 ng/ml). No significant correlation was found between the percentage reduction in blood pressure and Pl-Nifss in either of the two groups. There was a close relationship between Pl-Nifss and the concentration found 4 h after the morning dose. Side-effects were common during nifedipine monotherapy and were the reason for discontinuation of treatment in 4 of 18 patients. In contrast, none of the 9 patients on combined treatment dropped-out. In neither of the treatment groups was there any evidence for sodium retention and volume expansion during the first 4 weeks expressed as weight gain or signs of cardiac insufficiency. However, in 13 patients who continued on long-term treatment for 3–14 months, a definite need for concomitant diuretic therapy was found. The results indicate that nifedipine is effective in lowering blood pressure in patients with mild to moderate essential hypertension, either when given alone or in addition to beta-adrenoceptor blockade. It appears best tolerated as combination therapy. Long-term treatment requires addition of a diuretic. Pl-Nifss did not seem to be a major determinant of the magnitude of the hypotensive response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561384
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  • 10
    Electronic Resource
    Electronic Resource
    Antihypertensive and renal effects of orally administered verapamil (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 375-382 
    Details
    ISSN: 1432-1041
    Keywords: calcium antagonist ; verapamil ; hypertension ; vasodilators ; plasma renin activity ; mode of action ; sodium balance ; fluid balance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 12 in-patients with moderate uncomplicated hypertension, maintained on constant sodium intake for 15 days, single-blind oral administration of verapamil 80–160 mg t. i. d. for 10 days had a significant antihypertensive effect: in the supine position systolic blood pressure decreased from 177±5 to 150±3 mmHg, and diastolic pressure from 111±3 to 96±2 mmHg; standing values were similarly lowered from 171±7 to 143±4 mmHg, systolic, and from 118±4 to 97±2 mmHg, diastolic. The heart rate did not show any significant change (from 79±3 to 77±2 beats/min, supine, and from 92±3 to 87±3 beats/min, upright). The antihypertensive effect was uniform throughout the day, being similar 2, 3, 6 and 8 h after administration of a dose. Dynamic exercise (75–100 watts on a cycle-ergometer) caused identical increases in arterial pressure and heart rate on the last day of placebo and again on the last day with verapamil, but the peak levels of systolic pressure reached during exercise were lower after verapamil than with placebo, because of the lower blood pressure before exercise. Reduction of arterial pressure by verapamil was not accompanied by increased plasma renin activity, or by renal retention of sodium and water: there was a small increase in sodium excretion, at least during the first days of verapamil administration (from 107±15 to 113±15 mEq Na+/day), and a slight significant reduction in body weight (from 74.2±3.7 to 73.5±3.7 kg). It is concluded that oral administration of verapamil significantly lowers blood pressure without simultaneously inducing cardiac stimulation, renin secretion or salt and water retention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00636788
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  • 11
    Electronic Resource
    Electronic Resource
    Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 365-374 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; hypertension ; plasma renin activity ; pharmacokinetics ; pharmacodynamic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To show whether repeated administration of atenolol for several days would influence its pharmacokinetic parameters and the extent and duration of the pharmacologic responses, the plasma level of atenolol and changes in heart rate, blood pressure and plasma renin activity were measured in 12 hypertensive patients at various times of day (9 a. m., 12 noon, 3 p. m. and 7 p. m.) after oral administration of the first dose of atenolol 100 mg, again during the 7th and 14th days of continued once-daily administration of the same dose, and finally during the three days following withdrawal of the drug. The peak plasma concentration of atenolol (about 600 ng/ml) was found 3 h after administration of the first dose, and measurable amounts (50–70 ng/ml) were found after 24 h. None of the pharmacokinetic characteristics were changed by administration of a single daily dose for two weeks. After withdrawal of the drug, detectable amounts of atenolol were found in plasma for at least 48 h. The first dose of atenolol caused prompt (3 h) and prolonged (up to 24 h) lowering of supine and standing systolic and diastolic blood pressures, slowing of supine and standing heart rate, reduction of the blood pressure and heart rate responses to dynamic exercise, and a decrease in plasma renin activity. The extent and time-course of all these responses were not influenced by repeated once-daily administration of the 100 mg dose for two weeks. Most of the effects continued during the withdrawal days, the lowering of blood pressure being somewhat more prolonged than the slowing of heart rate. It is concluded that a once-daily dose of atenolol 100 mg decreases blood pressure and heart rate throughout the following 24 h, without excessive daily fluctuation in its effects, and without signs of tolerance or accumulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00636787
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  • 12
    Electronic Resource
    Electronic Resource
    Once-daily dosing of timolol in hypertension: A controlled study (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 239-241 
    Details
    ISSN: 1432-1041
    Keywords: timolol ; hypertension ; dose ranging ; double-blind trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nine previously untreated patients with mild-moderate hypertension were included in a dose-ranging double-blind trial to determine the effectiveness of daily versus thrice daily timolol administration. In 8 patients control of blood pressure was equally effective though with significantly lower heart rate achieved in the once daily group. One patient was not satisfactorily controlled on the daily regimen demonstrating that many but not all hypertensives can be controlled with daily administration of timolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00625796
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  • 13
    Electronic Resource
    Electronic Resource
    Relationship of propranolol pharmacokinetics to antihypertensive effect and beta-adrenergic blockade in the treatment of hypertension (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 391-394 
    Details
    ISSN: 1432-1041
    Keywords: propranolol ; hypertension ; beta-adrenergic blockade ; exercise heart rate ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of propranolol in 16 hypertensive patients was compared after the first oral dose of 80 mg and during chronic treatment with 80 mg bd. The degree of beta-adrenergic blockade was estimated by the reduction in maximal exercise heart rate. No significant change in plasma half-life occurred and there was no correlation between the mean steady-state propranolol concentration and beta-adrenergic blockade or antihypertensive effect. A linear relationship was observed between the decrease in blood pressure and the reduction in heart rate during maximal exercise. Therefore, the antihypertensive effect of propranolol can be explained by its peripheral beta-adrenergic blocking properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00636790
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  • 14
    Electronic Resource
    Electronic Resource
    Reserpine, hydrochlorothiazide and pituitary-gonadal hormones in hypertensive patients (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 329-332 
    Details
    ISSN: 1432-1041
    Keywords: reserpine ; hydrochlorothiazide ; pituitary hormones ; gonadal hormones ; hypertension ; serum concentration ; antihypertensive therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Sex histories and serum samples were obtained from 27 hypertensive men before and after 3 months of therapy with either 100 mg of hydrochlorothiazide or 0.25 mg of reserpine daily. Sera were analyzed for testosterone, dihydrotestosterone, estradiol, luteinizing hormone and prolactin. Both drugs effectively lowered blood pressure. The incidence of impaired sexual performance was low and insignificantly different in the two treatment groups. There were no significant changes in serum hormone concentrations as a result of drug therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558444
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  • 15
    Electronic Resource
    Electronic Resource
    Single daily dose penbutolol in the treatment of hypertension: A double blind crossover comparison with propranolol (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 409-413 
    Details
    ISSN: 1432-1041
    Keywords: penbutolol ; hypertension ; propranolol ; double-blind crossover comparison ; blood pressure ; heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Penbutolol is a potent long-acting non-cardioselective beta-adrenergic blocker with partial agonist activity. A double-blind cross-over comparison of penbutolol given in a single daily dose and propranolol given twice daily in the treatment of ambulant patients with moderate hypertension is described. Fourteen patients completed the study and were treated with each drug for 12 weeks. Penbutolol in daily doses of 20–120 mg and propranolol in daily doses of 80–400 mg produced similar significant reductions in both supine and erect blood pressure. Penbutolol did not reduce heart rate to the same extent as propranolol, in equivalent doses. Penbutolol appears to produce adequate control of moderate hypertension when administered once a day, and this effect appears to be equivalent to divided doses of propranolol. No serious adverse effects were reported, although one patient receiving penbutolol experienced severe eye pains at a dose of 40 mg which resolved on crossing over to treatment with propranolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00570156
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  • 16
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    Electronic Resource
    Influence of propranolol and pindolol on the haemodynamic effects of papaverine, isoprenaline and noradrenaline in hypertensive patients (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 141-146 
    Details
    ISSN: 1432-1041
    Keywords: papaverine ; propranolol ; pindolol ; hypertension ; isoprenaline ; haemodynamic effects ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of two β-adrenoceptor antagonists, propranolol and pindolol, on the haemodynamic effects of papaverine, isoprenaline and noradrenaline was investigated in 9 male patients with first degree essential hypertension. Propranolol and pindolol were given according to a doubleblind, crossover scheme. Heart rate and blood pressure were measured before and after each treatment. Propranolol 670 µg/kg i. v. reduced the supine and standing systolic blood pressures by 2.3% and 1.6%, respectively. Similarly, the intravenous administration of pindolol 35 µg/kg reduced supine and standing systolic blood pressure by 5.5% and 8.3% respectively (clinically insignificant). Neither drug affected diastolic blood pressure. Following propranolol, there were moderate reductions in supine and standing heart rates, respectively by 24% and 20% (p〈0.001). Similarly, but to a lesser extent, pindolol reduced supine and standing heart rate by 12% and 17% (p〈0.001). The effects of papaverine, which, at 1.5 mg/kg i. v. reduced systolic blood pressure by 5–10% and increased heart rate by 8–15%, were not significantly influenced by the β-blockers. The blood pressure and heart rate responses to isoprenaline, on the other hand, were attenuated or inhibited by both β-blockers. While the β-blockers inhibited the β-adrenoceptor component of noradrenaline, the pressor component of noradrenaline, which is mediated through the α-adrenoceptors, was not influenced by propranolol, but was inhibited after pindolol. It is concluded that pindolol differs qualitatively from propranolol in that it inhibited both the α-and β-adrenoceptor effects of noradrenaline.
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    URL: http://dx.doi.org/10.1007/BF00561581
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  • 17
    Electronic Resource
    Electronic Resource
    Time course of blood pressure, pulse rate, plasma renin and metoprolol during treatment of hypertensive patients (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 321-328 
    Details
    ISSN: 1432-1041
    Keywords: metoprolol ; hypertension ; pharmacokinetics ; plasma renin ; blood pressure effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eleven patients were treated for essential hypertension with metoprolol (Selokén®) for more than three months. The time course of changes in blood pressure, pulse rate and plasma renin activity was studied during treatment with an oral maintenance dose of 100 mg twice daily. Significant decreases in pulse rate, diastolic blood pressure and plasma renin activity were observed even after the first dose. The plasma concentration of metoprolol reached equilibrium after the second dose. After the third dose there was no further significant change in blood pressure. There was a significant correlation (p〈0.001) between the initial (after three doses) and final (after 〉90days) effect of metoprolol on blood pressure (r=0.86 and 0.91 for systolic and diastolic blood pressure change, respectively).
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    URL: http://dx.doi.org/10.1007/BF00558443
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  • 18
    Electronic Resource
    Electronic Resource
    Antihypertensive effect of fractionated sublingual administration of nifedipine in moderate essential hypertension (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 161-164 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; hypertension ; blood pressure ; heart rate ; plasma renin activity ; aldosterone ; clinical trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The magnitude and duration of the antihypertensive effect of nifedipine were studied in 7 cases of moderate essential hypertension. In a double-blind crossover study, nifedipine 10 mg or a placebo were administered sublingually 4 times a day for 2 days, and the results were compared. Each dose of nifedipine reduced systolic and diastolic blood pressure by 14% both in the supine and upright positions. The antihypertensive action lasted for about 3 h and it was not cumulative. The reduction in blood pressure was associated with a temporary increase in heart rate. Administration of nifedipine 10 mg did not significantly raise plasma renin activity or plasma aldosterone. The drug was well tolerated and no side effects were detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561894
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  • 19
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of atenolol in hypertensive subjects with and without co-administration of chlorthalidone (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 333-337 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; chlorthalidone ; hypertension ; chronic treatment ; co-administration ; plasma half-life ; urine half-life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of atenolol with and without the co-administration of chlorthalidone were studied in five hypertensive subjects. Concomitant administration of chlorthalidone appears to have little if any effect on the pharmacokinetics of atenolol during treatment for 7 days. The atenolol elimination half-lives were 6.7±1.1 and 6.3±0.9 h, respectively, with and without chlorthalidone. Two healthy volunteers also received a single 50 mg oral dose of chlorthalidone. Their blood profiles and pharmacokinetics were similar to those observed in hypertensive subjects, but a statistically significant difference (p〈0.01) was found between the urinary excretion half-lives of chlorthalidone. This difference may be because chronic administration of the drug caused saturation of red cell binding.
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    URL: http://dx.doi.org/10.1007/BF00558445
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  • 20
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    A gas-chromatographic method for the simultaneous determination of ethosuximide and valproate in serum (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 301 (1980), S. 108-109 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Ethosuximid, Valproat in Blutserum ; Chromatographie, Gas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Conclusion The proposed simultaneous determination of ethosuximide and valproate takes advantage of the similar properties of these substances that differ markedly from the other mainly used antiepileptic drugs. The volatility as well as the high blood concentration that are usual in therapeutics allow the measurement of ethosuximide and valproate directly in the extract without further concentration, e.g. by evaporation. On the other hand, one can optimise the methods for the determination of the other anticonvulsant drugs that are poorly volatile putting ethosuximide and valproate aside [1] and give up procedures using temperature programs with temperature differences of more than 100 ° C between the starting and the endpoint.
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    Effect of isoproterenol on adenylate cyclase activity in adipocytes of spontaneously hypertensive rats (1980)
    Springer
    Bulletin of experimental biology and medicine 90 (1980), S. 1082-1085 
    Details
    ISSN: 1573-8221
    Keywords: hypertension ; adrenalectomy ; fat cells ; isoproterenol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
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    URL: http://dx.doi.org/10.1007/BF00844539
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    Gas-chromatographische Bestimmung von Wasser mit dem Elektronen-Einfang-Detektor im Nanogramm-Bereich (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 302 (1980), S. 264-268 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Wasser in Organ. Lösungsmitteln ; Chromatographie, Gas ; ECD, 8–170 ppm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Wasser ist in organischen Lösungsmitteln im ng-Bereich gas-chromatographisch ohne Derivatisierung mittels eines linearisierten Elektroneneinfangdetektors (ECD) nach Abtrennung auf einer Porapak QS-Säule bestimmbar. Ausreichend wasserfreie Lösungsmittel ließen sich durch Trocknen mit aktivierten 4 Å-Molekularsieben oder superaktiven Aluminiumoxiden W 200, Woelm Pharma, Eschwege, herstellen. Um Wasserblindwerte aus der Raumluft auszuschließen, ist es notwendig, sämtliche Operationen in einer Box mit Umlauftrocknung durchzuführen. Wassermengen bis zu 15 ng absolut sind bestimmbar. Im Konzentrationsbereich 7–150 μg/ml ist die Detektoranzeige für Wasser linear.
    Notes: Summary Water can be determined directly in organic solvents in the ng range after separation on a porapak-QS column using a linear electron-capture detector (ECD). Organic solvents can be dried by activated 4 Å molecular sieves to a water content of 5 μg/ml, about 0.3×10−3 molar. To exclude water contamination all operations, storage of solvents and standards included, were made in a glove box with permanent drying of the inside atmosphere. The EC-detector allows to determine 15 ng of water absolute. In the range of 7–150 μg/ml a linear response for water by the ECD has been found.
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    New technique for the quantitation of micro amounts of biological substances by gas-liquid chromatography (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 303 (1980), S. 20-22 
    Details
    ISSN: 1618-2650
    Keywords: Analyse von Biolog. Substanzen, Steroidhormonen ; Chromatographie, Gas ; Anreicherungsverfahren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary A new technique for the quantitation of very low concentrations of biological substances by gas-liquid chromatography is described. It is based on the direct concentration of the substances to be measured at the inlet of the chromatographic column. This is accomplished by injection of the substance into the chromatographic apparatus, whose column is kept at the condensation temperature of the sample. Repeated injection in separate portions results in accumulation of the substance. Chromatography is readily achieved by heating to the optimal temperature. This technique yielded promising results in the quantitation of several steroid hormones.
    Notes: Zusammenfassung Das Verfahren beruht auf der direkten Konzentrierung der zu bestimmenden Substanzen am Eingang der chromatographischen Säule. Sie erfolgt durch Injektion der Substanzlösung in die Säule bei einer Temperatur niedriger als der Schmelzpunkt, so daß die Substanz nicht eluiert werden kann. Eine wiederholte Injektion einzelner Portionen führt zur Anreicherung der Substanz, die dann nach Erhöhung der Säulentemperatur chromatographiert werden kann. Das Verfahren wurde mit guten Ergebnissen zur Bestimmung einiger Steroidhormone angewendet.
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    Adaptive function of the sympathetic innervation of the cerebral vessels during rapid changes in systemic arterial pressure (1980)
    Springer
    Bulletin of experimental biology and medicine 90 (1980), S. 1510-1513 
    Details
    ISSN: 1573-8221
    Keywords: adaptation ; hemorrhage ; hypotension ; hypertension ; reinfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
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    URL: http://dx.doi.org/10.1007/BF00834079
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    Baseline studies of the global pollution (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 300 (1980), S. 387-402 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Hexachlorbenzol, Polychlorcamphenen, Toxaphen, Kohlenwasserstoffen, chlorierte in Biolog. Material ; Chromatographie, Gas ; Umweltbelastung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary Fishes have been used to characterize pristine aquatic environments. In samples from a lake in the Tyrolian Alps (arctic char) and Northwest Ireland (pike), the Caspian Sea (sturgeon/Sevruga), the North Atlantic (salmon), the North Pacific (salmon) and the Antarctic Ocean at South Georgia (antarctic cod) hexachlorobenzene and polychlorinated camphene (PCC, Toxaphene) have been found. Samples are extracted by n-hexane/acetone (2+1), following a dimethylformamide/hexane clean-up of the lipid matrix. Adsorption chromatography on Florisil (1.25% water content) allows the elution of hexachlorobenzene, 4,4′-DDE and the polychlorobiphenyls (PCB) with n-hexane, while the mixture nhexane/diethyl ether (90+10) will elute the polychlorocamphenes (PCC) together with the hexachlorocyclohexane isomers and the DDT group. Identification of the PCC has been done by matching their retention indices measured by high resolution ECD glass capillary gas chromatography using the nalkyl-trichloroacetates as references and technical Toxaphene together with a slightly dehydrochlorinated product as authentic samples. The PCC content of the samples from the lakes in the European Alps and Northwest-Ireland, the North Pacific and the Antarctic Ocean was 125, 240, 285 and 68 ng of PCC per g of extractable lipids, respectively. The samples from the Caspian Sea and the North Atlantic had 1,625 and 3,500 ng of PCC per g of extractable lipids, respectively. All samples but the one from the Antarctic Ocean (liver) were spawn. Besides hexachlorobenzene and the PCC all samples contained polychlorobiphenyls (PCB), theα, β andγ-isomers of hexachlorocyclohexane, the compounds of the DDT-group and many other ECD-dectable not yet identified compounds.
    Notes: Zusammenfassung In Fischproben aus in erster Näherung unbelasteten Gebieten, dem Nordatlantik (Lachs), einem See in Nordwest-Irland (Hecht), einem Hochalpensee (Bergsaibling), dem Kaspischen Meer (Sternhausen), dem Nordpazifik (Lachs) und dem Antarktischen Ozean bei Südgeorgien (Antarktischer Dorsch) lassen sich Hexachlorbenzol und polychlorierte Camphene (PCC, Toxaphen®) nachweisen. Die Probe wird mit n-Hexan/Aceton (2+1) extrahiert. Die Lipide werden über eine Dimethylformamid/Hexan-Verteilung weitgehend abgetrennt. Adsorptions-Chromatographie an Florisil mit 1,25% Wassergehalt erlaubt die Elution von Hexachlorbenzol, 4,4′-DDE und der polychlorierten Biphenyle (PCB) mit n-Hexan; n-Hexan/Diethylether (90+10) eluiert die polychlorierten Camphene zusammen mit den Hexacyclohexan-Isomeren und der DDT-Gruppe. Die Identifizierung der PCC gelang über Vergleich der mit ECD-Capillar-Gas-Chromatographie unter Bezug auf die n-Alkyltrichloracetate gemessenen Retentionsindices. Als Standardsubstanz diente technisches Toxaphen, sowie ein durch methanolische KOH leicht dehydrochloriertes Produkt. Der PCC Gehalt lag bei den Proben aus dem Hochalpensee, einem See in Nordwest-Irland, dem Nordpazifik und dem Antarktischen Ozean bei 125, 240 bzw. 285 und 68 ng PCC/g extrahierbare Lipide. Die Proben aus dem Kaspischen Meer und dem Nordatlantik enthielten 1 625 bzw. 3 500 ng PCC/g extrahierbare Lipide. Bis auf die Probe aus der Antarktis (Leber) handelte es sich jeweils um Rogen. Neben dem Hexachlorbenzol und den Polychlorcamphenen wurden in allen Proben polychlorierte Biphenyle, dieα, β undγ-Isomeren des Hexachlorcyclohexans, die DDT-Gruppe und zahlreiche weitere bisher nicht identifizierte, mit dem ECD nachzuweisende Verbindungen gefunden.
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    Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 302 (1980), S. 20-31 
    Details
    ISSN: 1618-2650
    Keywords: Analyse von Polychlorbiphenylen, Aroclor, Clophen ; Chromatographie, Gas ; Glascapillaren, Electron capture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary The composition of seven technical PCB-mixtures (Aroclor [Monsanto, USA] und Clophen A [Bayer, FRG]) has been investigated by high-resolution thin-film glass capillary gas chromatography with electron-capture detector. Methylpolysiloxane (SE 30) and purified Apiezon L have been used as liquid phases. Identification of the single PCB components has been performed by comparison of their retention indices with those of polychlorinated biphenyls defined by synthesis or with values calculated from retention index increments. For marking the individual PCB compounds a systematic numbering has been used.
    Notes: Zusammenfassung Die Zusammensetzung sieben technischer Gemische polychlorierter Biphenyle (PCB) mit unterschiedlichem Chlorierungsgrad (Aroclor- [Monsanto, USA] und Clophen A- [Bayer, Bundesrepublik Deutschland]-Typen) wurde mit hochauflösender Gas-Chromatographie mit Elektroneneinfang-Detektion in Dünnfilm-Glascapillaren mit Methylpolysiloxan (SE 30) und gereinigtem Apiezon L als flüssiger Phase untersucht. Die Identifizierung der Einzelkomponenten erfolgte durch chromatographischen Vergleich mit definierten Referenzsubstanzen oder Vergleich der aus Inkrementen berechneten Retentionsindices. Für die Kennzeichnung der Einzelkomponenten wird eine systematische Numerierung entsprechend der Substituentenbezifferung verwendet.
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    Gas-chromatographische Bestimmung von Spuren von n-Butylzinnverbindungen (Tetra-, Tri-, Di-) in Luft (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 304 (1980), S. 23-27 
    Details
    ISSN: 1618-2650
    Keywords: Best. von n-Butylzinnverbindungen in Luft ; Chromatographie, Gas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung n-Butylzinnverbindungen (Tetra-, Tri-, Di-) wurden aus der angesaugten Luft an Chromosorb 102 adsorbiert, mit HCl-haltigem Diethylether desorbiert, falls nötig mit Methylmagnesiumchlorid umgesetzt und die methylierten Verbindungen gas-chromatographisch mit einem zinnspezifischen flammenphotometrischen Detektor bestimmt. Die mittlere Wiederfindungsrate (0,09–40 μg) von Bis(tri-n-butylzinn)oxid (TBTO) betrug: 93,3%; Streubereich der Einzelwerte ± 9,3% (P=95%, N=11). Wird 1 m3 Luft angesaugt, lassen sich noch Konzentrationen an n-Butylzinnverbindungen (Tetra-, Tri-, Di-) von 0,05 μg/m3 bestimmen. In einem mit einer TBTO-haltigen Dispersionsfarbe gestrichenen Raum wurde die Temperaturabhängigkeit der Tri-n-butylzinn-Konzentration in der Luft untersucht. Der Vergleich mit den Resultaten von Bestimmungen des Totalzinngehaltes läßt den Schluß zu, daß in der Luft nur Tri-n-butylzinnverbindungen vorlagen.
    Notes: Summary n-Butyltin compounds (tetra-, tri-, di-) have been adsorbed on Chromosorb 102 from the aspired air, desorbed with HCl-containing diethylether and, if necessary, converted to the corresponding methyl derivatives by reaction with methylmagnesium chloride. The derivatives were determined by GLC with a tin-specific flame photometric detector. The mean recovery (0.09–40 μg) of bis(tri-n-butyltin)oxide (TBTO) was 93.3%; tolerance limit ±9.3% (P=95%, N=11). With an air sample of 1 m3 it is possible to measure n-butyltin compounds (tetra-, tri-, di-) in concentrations down to 0.05 μg/m3. In a room coated with a TBTO-containing latex-based paint, the temperature dependence of the tri-n-butyltin concentration in the air has been studied. Comparison with results of total tin determinations allows the conclusion that the air contained only tri-n-butyltin compounds.
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    New reagents for the on-column methylation of phenolic compounds: Trimethylanilinium acetate, trimethylselenium hydroxide and trimethylselenium acetate (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 301 (1980), S. 143-143 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Phenolen ; Chromatographie, Gas ; neue Methylierungsreagentien
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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    URL: http://dx.doi.org/10.1007/BF00467785
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    Gas-chromatographic determination of the components of waste water from dimethylterephthalate production (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 301 (1980), S. 432-433 
    Details
    ISSN: 1618-2650
    Keywords: Analyse von Abwasser der Dimethylterephthalat-Produktion ; Chromatographie, Gas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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    URL: http://dx.doi.org/10.1007/BF00475754
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    Gas-chromatographische Analyse von Hydroxyfettsäuren in komplexen Gemischen mit Hilfe des Elektroneneinfangdetektors (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 303 (1980), S. 126-127 
    Details
    ISSN: 1618-2650
    Keywords: Analyse von Hydroxyfettsäuren ; Chromatographie, Gas ; ECD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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    URL: http://dx.doi.org/10.1007/BF00470948
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    Analytische Charakterisierung von Verdickungsmitteln auf Polysaccharidbasis (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 303 (1980), S. 279-288 
    Details
    ISSN: 1618-2650
    Keywords: Analyse von Polysacchariden, Verdikkungsmitteln, Celluloseethern ; Chromatographie, Gas ; Zeisel-Spaltung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Im vorliegenden zweiten Teil der dreiteiligen Übersicht zur Analytik der Polysaccharide wird am Beispiel einer Methylhydroxyethylcellulose (MHEC) die Erfassung der Celluloseether und -mischether mittels der Gas-Chromatographie vorgestellt. Dabei handelt es sich um die Beschreibung einer quantitativen Methode hoher Empfindlichkeit, die erforderlich ist, um Cellulosederivate mit geringer Mischsubstitution zu identifizieren und zu unterscheiden. Dazu werden die Celluloseether in einer speziell entwickelten Apparatur mit Iodwasserstoffsäure bei 140°C erhitzt. Von den sich bildenden Spaltprodukten werden die abdestillierten Alkyliodide in gekühltem Hexylbromid aufgefangen, gas-chromatographisch getrennt und identifiziert; gebildete Olefine werden durch Bromaddition erfaßt. Reproduzierbarkeit: ≤3% rel. Erfassungsgrenze: = 0,01% Hydroxyethylcellulose (HEC). Die Methode eignet sich auch zur Erfassung von Estern, S-Alkylgruppen, Methylimidverbindungen, Glykolanteilen oder bestimmten Tensiden.
    Notes: Summary In this second part of the three-part review on analysis of polysaccharides the characterization of cellulose ethers and cellulose mixed ethers by means of gaschromatography is described. The identification of the wide varying field of this cellulose ethers is presented using methylhydroxyethylcellulose (MHEC) as an example. To differentiate all cellulose mixed ethers, even those with little substitution of one of the two ether components, the method has to work qualitatively and quantitativly with a high sensitivity. The cellulose ethers are treated with hydriodic acid at 140°C in a special apparatus. The alkyliodides formed are distilled into cooled hexyl bromide. They are separated and identified by gaschromatography. Olefins also formed are determined by addition of bromine. Reproducibility: ≤ 3% rel. Limit of detection: = 0.01 % Hydroxyethylcellulose (HEC). This method can also be used for the determination of esters, S-alkyl groups, methylimides, glycols and some detergents.
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    Gas-chromatographic determination of benzo(a)pyrene in petroleum products used for the manufacture of drugs and cosmetics (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 303 (1980), S. 397-400 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Benzo(a)-pyren in Erdölprodukten ; Chromatographie, Gas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary A gas-liquid chromatographic method has been developed for the quantitive determination of benzo(a)-pyrene in petroleum products. At the 2 ppb benzo(a)pyrene level in a sample, the recovery is 87–90%. The detection limit is 50 ng. A column was employed with a liquid-crystal phase of bis(p-phenylbenzylidene)-bi-p-toluidine on Chromosorb.
    Notes: Zusammenfassung Das entwickelte gas-chromatographische Verfahren benutzt eine SÄule mit der Flüssig-Kristallphase von Bis(p-phenylbenzyliden)-bi-ptoluidin auf Chromosorb und gestattet im Bereich von 2 ppb Benzo(a)-pyren eine Wiederfindung von 87–90%. Die Nachweisgrenze liegt bei 50 ng.
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    Bestimmung von Rückständen von Organochlorinsecticiden im Boden (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 301 (1980), S. 32-32 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Hexachlorcyclohexan, Hexachlorbenzol in Boden ; Chromatographie, Gas ; Extraktion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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    URL: http://dx.doi.org/10.1007/BF00481274
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    Bestimmung von Rückständen von Organochlorinsecticiden (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 304 (1980), S. 143-143 
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    ISSN: 1618-2650
    Keywords: Best. von Hexachlorcyclohexan, Hexachlorbenzol im Wasser ; Chromatographie, Gas ; Extraktion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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    URL: http://dx.doi.org/10.1007/BF00474374
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    Qualitative and quantitative analysis of the n-alkanes C9-C17 and pristane in clean air masses (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 302 (1980), S. 375-381 
    Details
    ISSN: 1618-2650
    Keywords: Best. von n-Alkanen, Pristan in Luft ; Chromatographie, Gas ; reine Luft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary An analytical method was developed for measuring n-alkanes (C9 to C17) and other hydrocarbons in tropospheric air with mixing ratios of a few ppt (10−12) and higher. The hydrocarbons are collected in situ in absorption tubes, carefully protected against contamination and analysed later in the laboratory by gas chromatography. First data are reported for Atlantic air masses at the west coast of Ireland.
    Notes: Zusammenfassung Es wurde eine analytische Methode entwickelt zur Messung der n-Alkane (C9 bis C17) und anderer Kohlenwasserstoffe in reiner troposphärischer Luft mit Mischungsverhältnissen von einigen ppt (10−12) und aufwärts. Die Kohlenwasserstoffe wurden am Beobachtungsort angereichert, sorgfältig gegen Verunreinigung geschützt und später im Laboratorium gas-chromatographisch analysiert. Erste Daten für atlantische Luftmassen an der Westküste Irlands werden mitgeteilt.
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    Gas-chromatographic determination of hydrogen in magnesium by means of the capsule method (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 302 (1980), S. 398-401 
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    ISSN: 1618-2650
    Keywords: Best. von Wasserstoff in Magnesium ; Chromatographie, Gas ; Kapselmethode
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary A new method, the capsule method, has been developed for analyzing hydrogen in magnesium with a standard deviation of about 4%. 1–2 g samples are made with a smooth surface and enclosed in a degassed iron capsule. The surface humidity is removed by a short annealing at 400°C, and the sample is subsequently degassed at 500–620°C in vacuum. The extracted hydrogen is measured by gas chromatography. The commercial magnesium analyzed contained from 0.2 to 8 ppm of hydrogen. The diffusion coefficient of hydrogen was measured to be: D=D 0e−Q/RT; where D 0=9.5 · 10−6 m2/s and Q=46,400 Joule/mole. The results obtained were interpreted as interstitial diffusion of hydrogen in magnesium.
    Notes: Zusammenfassung Zur Analyse von Wasserstoff in Magnesium wurde eine neue Methode, die Kapselmethode, entwickelt, 1–2 g schwere Proben werden mit einer glatten Oberfläche hergestellt und in eine gasfreie Kapsel eingeschlossen. Die Oberflächenfeuchtigkeit wird durch kurzes Anlassen bei 400°C entfernt und die Probe wird danach bei 500–620°C im Vakuum entgast. Der entfernte Wasserstoff wird mit einem Gas-Chromatographen gemessen. Die Standardabweichung beträgt etwa 4%. Das untersuchte technische Magnesium enthält zwischen 0,2 und 8 ppm Wasserstoff. Der gemessene Diffusionskoeffizient für Wasserstoff ist: D=D 0e−Q/RT; D 0=9.5 · 10−6 m2/s und Q= 46400 Joule/Mol. Die erhaltenen Resultate wurden als interstitielle Wasserstoffdiffusion im Magnesium interpretiert.
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    Gas-chromatographic elemental analysis via di(trifluoroethyl)dithiocarbamatochelates (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 303 (1980), S. 389-393 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Chrom(III), Chrom(VI) in Wasser ; Chromatographie, Gas ; Extraktion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary The gas-chromatographic determination of Cr(III) and Cr(VI) in aqueous solution using di(trifluoroethyl)dithiocarbamate as an extracting agent (pH 3) is described. Best results were obtained with a column of OV-25 (3% on Chromosorb HPW, 100–120 mesh, 160–210
    Notes: Zusammenfassung Die Extraktion mit dem Reagens wird bei pH 3 durchgeführt. Als SÄulenmaterial hat sich am besten OV-25 (3% auf Chromosorb HPW, 100–120 mesh, 160–210
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    Baseline studies of the global pollution (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 304 (1980), S. 337-349 
    Details
    ISSN: 1618-2650
    Keywords: Analyse von Biphenylen, polychlorierten in Umweltmaterial ; Chromatographie, Gas ; Glascapillar
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary The PCB-pattern of biological environmental samples of different trophic levels (fish, bird, man) and geographic areas (Alps, North Sea, North Atlantic) as seen by high-resolution glass capillary gas chromatography with electron capture detection is presented. The most evident variation of the pattern compared to a best fit simulation by technical mixtures is found for warm blooded species (eggs of birds and human milk). Only one trichloro-, but nine tetrachloro-biphenyls and 55 penta-to octachloro-biphenyls have been identified as PCB-components in biological samples. Compounds with 4,4′-disubstitution degrade very slowly, if at all (1,4-recalcitrance principle). Single component analysis of PCB in marine samples using glass capillary gas chromatography needs the preseparation from the ubiquitous polychloroterpenes (toxaphene, polychlorocamphene) and the DDT-group. Both complex mixtures can be separated successfully by adsorption chromatography on Florisil. Quantitation of PCB as a sum has been done by using recalcitrant diagnostic components and PCB-Clophen A 60 as the reference standard.
    Notes: Zusammenfassung Die Bestimmung der Einzelkomponenten der polychlorierten Biphenyle (PCB) in Umweltproben durch Glascapillar-Gas-Chromatographie auf Methylsilicon- oder Apiezon L-Phasen erfordert eine Vortrennung von den Polychlorterpenen (Toxaphen, Polychlorcamphen) und der DDT-Gruppe. Diese Trennung gelingt durch Adsorptions-Chromatographie auf Florisil. Die PCB-Muster im Fett des phytoplanktonfressenden Seefisches Menhaden (Brevoortia tyrannus) aus dem Nordatlantik, im Rogen der zooplanktonfressenden Salmoniden Seesaibling (Salvelinus alpinus) und Bachforelle (Salmo trutta m. fario) aus Bergseen in Tirol, und in der Leber der Süßwasserdorschart Quappe (Lota lota) aus dem Bodensee werden gezeigt. Die stärksten Veränderungen gegenüber einer aus technischen Gemischen hergestellten Simulationsmischung werden für Warmblütlerproben — Eier von Brandgans (Tadorna tadorna) und Küsten-Seeschwalbe (Sterna paradisea); Humanmilch — gefunden. Neben einem Trichlor- und neun Tetrachlorbiphenylen wurden 55 Pentabis Octachlorbiphenyle nachgewiesen. Komponenten mit einer 4 und/oder 3,5-Substitution in beiden Ringen werden beträchtlich langsamer abgebaut als anders strukturierte Komponenten (1,4-Rekalzitranz-Prinzip). Die Quantifizierung der PCB als Summe erfolgte über schwer abbaubare, signifikante Hauptkomponenten unter Verwendung eines Clophen A 60 PCB-Gemisches als Eichstandard.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00480602
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