Summary
Six hypertensive patients were treated with prazosin up to a final dose of 3–4.5 mg/day. There was a significant reduction of blood pressure. The cerebrospinal fluid (CSF) concentrations of the major metabolites of noradrenaline, dopamine and serotonin were unchanged. This indicates that the antihypertensive effect is not mediated via central monoaminergic neurons as suggested by animal studies.
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References
Andén NE, Gomes C, Persson B, Trolin G (1978) R 28935 and Prazosin: Effects on central and peripheral alpha-adrenoreceptor activity and on blood pressure. Naunyn Schmiedebergs Arch Pharmacol 302: 299–306
Bertilsson L, Atkinson AJ, Althaus JR, Härfast Å, Lindgren JE, Holmstedt B (1972) Quantitative determination of 5-hydroxyindole-3-acetic acid in cerebrospinal fluid by gas chromatography-mass-spectrometry. Anal Chem 44: 1434–38
Bertilsson L (1973) Quantitative determination of 4-hydroxy-3-methoxyphenyl glycol and its conjugates in cerebrospinal fluid by mass fragmentography. J. Chromatogr 87: 147–153
Bertilsson L, Haglund K, Östman J, Rawlins MD, Ringberger V-A, Sjöqvist F (1977) Monoamine metabolites in cerebrospinal fluid during treatment with clonidine or alprenolol. Eur J Clin Pharmacol 11: 125–128
Day MD, Roach AG (1974) Central adrenoceptors and the control of arterial blood pressure. Clin Exp Pharmacol Physiol 1: 347–60
Fuller RW, Snoddy HD, Perry KW (1977) Effect of prazosin on norepinephrine turnover in rat brain. Fed Proc 36: 407
Kincaid-Smith P, Hua ASP, Myers JB, Macdonald I, Fang P (1976) Prazosin and hydralazin in the treatment of hypertension. Clin Sci Mol Med 51: 617–19
Lund-Johansen P (1974) Hemodynamic changes at rest and during exercise in longterm prazosin therapy of essential hypertension. In: Rawlins MD, Geyer G, Bleifeld W (eds) Prazosin. Evaluation of a new anti-hypertensive agent. Excerpta Medica, Geneva, pp 43–45
Offerhaus L, van Zwieten PA (1974) Comparative studies on central factors contributing to the hypotensive action of propranolol, alprenolol and their enantiomers. Cardiovasc Res 8: 488–95
Rosenthal J, Jaeger H, Arlart I (1978) Effects of prazosin on blood pressure and plasma renin activity in man. Clin Sci Mol Med 55: 337–339
Sjöquist B, Änggård E (1972) Gas chromatographic determination of homovanillic acid in human cerebrospinal fluid by electron capture detection and by mass fragmentography with a deuterated internal standard. Anal Chem 44: 2297–2301
Van Zwieten PA (1973) The central action of antihypertensive drugs, mediated via central α-receptor. J Pharm Pharmacol 25: 89–95
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Seideman, P., Bertilsson, L., Haglund, K. et al. Monoamine metabolites in cerebrospinal fluid during treatment of hypertension with prazosin. Eur J Clin Pharmacol 18, 399–401 (1980). https://doi.org/10.1007/BF00636792
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DOI: https://doi.org/10.1007/BF00636792