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  • 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
  • 550 - Earth sciences
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  • Commission for the Geological Map of the World
  • Community Online Resource for Statistical Seismicity Analysis
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  • Essen : Verl. Glückauf
  • Krefeld : Geologischer Dienst Nordhein-Westfalen
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  • 1
    Publication Date: 2021-03-01
    Description: Questo lavoro presenta una utility per il GIS MapInfo™ sviluppata per l'archiviazione ed elaborazione dei dati macrosismici dalla fase di georeferenziazione fino al plottaggio finale su mappa. L'identificazione della località associata con un'osservazione macrosismica è un'operazione che talvolta può causare errori ed in seguito problemi nell'analisi ed interpretazione dei dati. La routine MacroMap fornisce uno strumento che in modo semplice e veloce aiuti nell'identificazione della corretta località a cui attribuire l'informazione macrosismica durante lo studio di un terremoto. L'utility è strutturata per utilizzare il formato della directory geografica DIR04 e le procedure adottate nella compilazione del DataBase Macrosismico Italiano DBMI04. MacroMap è stata sperimentata "sul campo" durante alcune indagini macrosismiche e tiene conto dell'esperienza e dei suggerimenti degli operatori del Gruppo QUEST (QUick Earthquake Survey Team). I campi di utilizzo di MacroMap vanno dalla realizzazione speditiva di mappe e tabelle per la produzione di report macrosismici per la Protezione Civile, alla revisione di terremoti storici, grazie all'avanzato sistema di query disponibile per la selezione dei toponimi del database geografico.
    Description: Published
    Description: 1-21
    Description: 5.1. TTC - Banche dati e metodi macrosismici
    Description: N/A or not JCR
    Description: open
    Keywords: Osservazioni macrosismiche ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring ; 05. General::05.02. Data dissemination::05.02.02. Seismological data
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
    Publication Date: 2017-04-04
    Description: Mostly based on traditional catalogues, without further research, several modern parametric catalogues are nevertheless straightforward, without question marks, and easily misleading (chronology, epicentre, epicentral intensity, not to speak of magnitude). The example of an Ionian time-window (1658-1664), with several major events, shows that the historical seismicity of the Ionian Islands, often thought to be well-known, actually needs a more or less drastic revision. A wealth of sources was collected, mostly from the Archives of the Republic of Venice, then ruling the main three islands of the Ionian Archipelago; it was ascertained that there are no important chronological gaps in the surviving documentation. Similarly outstanding, and in fact at the basis of a more balanced and precise view of one of the events in this time-window, are the souvenirs of Christoff von Degenfeld, a German nobleman at the service of the Republic of Venice. His manuscript, discovered at the library of Karlsruhe (Germany) in 1992, has been consulted again in the original, on the occasion of the preparation of this paper. Some question marks remain on the distributions of macroseismic effects of the earthquakes within this time-window, and this is due to the lack of information concerning the mainland. For this reason this study does not propose epicentres and, of course, magnitudes. An unusually long documentary appendix is provided, with the hope that it might contribute in discouraging authors of parametric earthquake catalogues from hasty exploitation and interpretation of often unreliable current catalogues.
    Description: Published
    Description: 43-91
    Description: 3.10. Sismologia storica e archeosismologia
    Description: open
    Keywords: Historical seismology ; Ionian Islands 1658-1664 ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 3
    Publication Date: 2017-04-04
    Description: Most of the ancient town of Tindari (NE, Sicily) was settled on a plateau the most surficial layer of which was made of unconsolidated material. Ongoing excavations at the archaeological site at Tindari uncovered a large portion of the decumanus which suffered deformations preliminarily assigned to coseismic effects. An analysis of the local dynamic response through the simulation of strong seismic shaking to the bedrock and modelling of spectral ratios of the bedrock-soft soil was carried out to verify the susceptibility of superficial terrains of the promontory to coseismic deformations. To perform this simulation the finite element method (FEM) was used. Four accelerometric recordings of three earthquakes of medium-high magnitude, recorded on rocky sites, were chosen to simulate the seismic shaking, using a constitutive law for the materials composing the promontory layers both of linear-elastic type and of elastoplastic type. The analysis of the linear-elastic field allowed the definition of the frequencies for which the spectral ratios of the accelerations recorded the highest amplifications; in particular the frequency range 31.5–37.2 Hz can be combined with deformation of the paved floor of the decumanus. The analysis in the elastoplastic field highlighted the zones of promontory more susceptible to suffer plasticization process. The results show that the topmost layer of the decumanus is the most susceptible to suffer plasticization. Therefore, the performed analysis lends greater support to the hypothesis that the deformations were produced by seismic shaking.
    Description: Published
    Description: 213-222
    Description: 3.10. Sismologia storica e archeosismologia
    Description: JCR Journal
    Description: reserved
    Keywords: Fourier analysis ; Elasticity and anelasticity ; Earthquake ground motions ; Site effects ; Computational seismology ; 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 4
    Publication Date: 2017-04-04
    Description: RIASSUNTO Il terremoto dell’8 settembre 1905 in Calabria è considerato uno degli eventi più forti della storia sismica italiana, ma paradossalmente, pur essendo abbastanza recente, anche uno dei terremoti la cui conoscenza è più lacunosa. Localizzazione, magnitudo e geometria della sorgente sono ancora sostanzialmente parametri poco vincolati. Il terremoto produsse una grande quantità di effetti ambientali, sui terreni e sulle acque, ed effetti “anomali” percepiti dalla gente, come rombi e fenomeni luminosi. Scopo del presente lavoro è di presentare in un unico repertorio la raccolta di tali osservazioni per fornire un quadro degli effetti associati all’evento. La raccolta è avvenuta selezionando le testimonianze contenute nelle fonti, preferibilmente coeve, che trattano del terremoto del 1905, catalogandole per tipologia e descrivendole. Il database finale è relativo ad osservazioni di effetti associati al terremoto in 122 località. Gli effetti geologici e quelli idrologici sono stati usati per calcolare empiricamente dei valori di magnitudo. Per ognuno dei fenomeni osservati abbiamo anche riassunto lo stato delle conoscenze nella letteratura scientifica, antica e contemporanea. ABSTRACT The September 8, 1905 Calabria (Southern Italy) earthquake belongs to a peculiar family of highly destructive seismic events, mostly occurred at the dawning of the instrumental seismology, for which location, geometry and size of the source are still substantially unconstrained. For instance, during the century-long period elapsed since the earthquake, previous Authors calculated magnitudes between M≤6.2 and M=7.9. In this paper we collected a remarkable dataset of environmental effects produced by the earthquake (more than 220 deeply reviewed observations at 122 different localities) retrieved in the coeval sources. Our data include ground effects (landslides, rock falls and lateral spreads), hydrological changes (streamflow variations, liquefaction, rise of water temperature and turbidity), earthquake lights, earthquake sounds. Finally, we define the magnitude of the event using some empirical relation between seismic parameters and distribution of ground effects and hydrological changes.
    Description: Published
    Description: 1-19
    Description: 3.10. Sismologia storica e archeosismologia
    Description: N/A or not JCR
    Description: open
    Keywords: calabria 1905 ; effetti ambientali ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 5
    Publication Date: 2017-04-04
    Description: Jean Vogt was born in 1929 in Strasbourg (France), where he attended primary and secondary school. At the University of Strasbourg, he graduated in Geography, and majored in Geomorphology. His professor was the geographer Jean Tricart, who taught him the importance of both geological field work and archive investigation. In 1955 he joined the French West-Africa Geological Service and later the French Bureau for Geology and Mines (BRGM). Along the following 20 years he lived as a “geological” globetrotter in a number of countries, dispensing his time between the field and the archives. In these years, he was concerned mainly with mining geology, geomorphology, superficial deposits, and landslides. This unique experience led him in 1975 to the responsibility of the “Seismo-Tectonic Project”, the BRGM project in relation with the French nuclear power programme. From 1975 to 1984, he gave a substantial impulse to the study of French historical earthquakes, and since then he visited almost every public archive in France, and several major archives and libraries in Europe and abroad. He took care at the same time of the follow-up of macroseismic studies of present-day earthquakes. After he retired in 1984, he continued on a personal basis his investigations of historical earthquakes, in Europe, the Middle East, North Africa, and the Caribbean area. Alongside and for about 50 years, Jean Vogt investigated uninterruptedly the agrarian history of Northeastern France and Southwestern Germany. He published in scientific journals and in local learned societies bulletins more than 500 notes and articles devoted to a variety of subjects, such as soil erosion, agriculture, cattle trade, and social conflicts. Jean Vogt died on 5 June 2005 in Strasbourg. His scientific legacy consists of a wealth of published papers, manuscripts, documentation related to history and seismology, awaiting to be further exploited, as he would have done.
    Description: Published
    Description: 3-16
    Description: 3.10. Sismologia storica e archeosismologia
    Description: reserved
    Keywords: Jean Vogt ; biography ; historical seismology ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 6
    Publication Date: 2017-04-04
    Description: The recent seismological literature recorded three strong earthquakes in Algeria, Libya and Tunisia between 1656 and 1694 AD. The historical evidence for these derives from European sources only (gazettes, journalistic pamphlets, missionary literature). Considering the kind of sources involved, their likely biases and the geographical distances that divided their places of production from the places that they spoke about, it is possible that some of these accounts could be less than reliable, and therefore have little use as materials from which to assess earthquake parameters. To answer these doubts, we have retrieved, cross-checked and critically analysed the original historical sources quoted in previous compilations and studies.
    Description: Published
    Description: 163-184
    Description: 5.1. TTC - Banche dati e metodi macrosismici
    Description: reserved
    Keywords: Historical Seismicity ; North Africa Earthquakes ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 7
    Publication Date: 2017-04-04
    Description: In the summer of 1561, a strong seismic sequence struck southern Italy, then the Spanish-ruled Kingdom of Naples. Both the Italian seismological tradition and the latest catalogues locate it in the Vallo di Diano (Diano Valley), a low-seismicity intermontane basin 100 km south-east of Naples. We explore the hypothesis that current perception of the 1561 earthquake is distorted by the nature of the historical dataset from which its parameters have been assessed, and which mostly derive from a single—albeit very detailed—primary source. We present and discuss several previously unconsidered original accounts. Our results cast doubts on the traditional interpretation of the earthquake, which could have been either one Vallo di Diano mainshock or several strong earthquakes within a time/space window compact enough for contemporary viewers to perceive them as one. Unquestionably, there is much more to the 1561 earthquake(s) than previously appeared. We hope that this groundbreaking effort will rekindle the interest of the seismological community in this seismic episode, our knowledge of which is still far from complete.
    Description: Published
    Description: 1054-1077
    Description: 5.1. TTC - Banche dati e metodi macrosismici
    Description: JCR Journal
    Description: reserved
    Keywords: Hitorical Seismicity ; 1561 Earthquakes ; Active Faults ; Seismotectonics ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 8
    Publication Date: 2017-04-04
    Description: Durante la seconda guerra mondiale un tratto della catena appenninica al confine tra Marche, Umbria e Lazio fu interessato da alcuni terremoti moderatamente dannosi, di cui non si trova quasi traccia nei cataloghi parametrici correnti. Il terremoto del 19 dicembre 1941, ben attestato da fonti storiche, non è stato mai registrato da alcun catalogo sismico. Quelli del 16 e 29 gennaio 1943 figuravano nei cataloghi parametrici di prima generazione [Carrozzo et al., 1973; Postpischl, 1985] ma sono scomparsi da quelli più recenti, compilati col metodo del declustering [Camassi e Stucchi, 1998; Gruppo di Lavoro CPTI, 1999-2004]. Il terremoto del 25 marzo 1943 figura nei cataloghi più recenti ma con parametri derivati da una base di dati macrosismici molto ristretta. Durante una ricerca (in corso) sul terremoto di Offida-Castignano del 3 ottobre 1943 sono stati raccolti dati storici che hanno permesso di ricostruire il campo macrosismico di questi terremoti “dispersi”, assegnare le intensità mediante la scala EMS98 e produrre le rispettive stringhe parametriche di sintesi. Questa esperienza ci ricorda che quella dell’incompletezza dei cataloghi sismici è una questione che non riguarda solo i secoli più remoti ma, a volte, anche periodi molto recenti.
    Description: Published
    Description: 1-23
    Description: 3.10. Sismologia storica e archeosismologia
    Description: N/A or not JCR
    Description: open
    Keywords: terremoti sconosciuti, cataloghi, seconda guerra mondiale ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 9
    Publication Date: 2017-04-04
    Description: While the seismicity of the Southern Alps is high in the Eastern sector, corresponding to the Veneto and Friuli regions, it decreases towards West up to the Adda River. In the sector between the Lessini Mts. and Eastern Friuli the damaging earthquakes are clustered in a well defined seismic belt, where seismogenic sources responsible for earthquakes with Mw 6 have been defined in recent works. In contrast, the knowledge of the Southalpine sector West of this area is sparser; the area experienced some earthquakes with Mw〉5.5 and varied events with 4.8≤Mw≤5.5 the distribution of which is, apparently, random. For the area roughly defined by the basins of the Adda River to the West and the middle Adige River to the East, this paper reappraises the background knowledge of the earthquakes occurred before 1700. The investigation and the results are presented according to two successive periods, up to 1995 and from 1995 on. In the research performed up to 1995, the most important achievements concerned two different aspects: i) the assessement of several “fake quakes”, some of which were the object of paradigmatic case-histories; ii) the resizing and relocation of several, presumed damaging earthquakes. Though this round of investigation changed significantly the picture of the seismicity with respect to the Seventies, the research continued. For the period from 1995 on, the discussion focuses on the reliability of the available information; material that received little or no consideration before, new historical findings and comments to the seismological interpretation as in the most recent literature are also presented. This part includes also the discussion of archaeoseismological evidence of damage related to past earthquakes.
    Description: Published
    Description: 93-129
    Description: 3.10. Sismologia storica e archeosismologia
    Description: reserved
    Keywords: historical seismology ; Adda and Middle Adige River Basins ; Southern Alps ; archaeoseismology ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 10
    Publication Date: 2017-04-03
    Description: The Valtiberina region (central Italy) has a seismic record going back to the Middle Ages and including five Io 〉 VIII MCS earthquakes, the earliest of which (1352, 1389, 1458). though recently and extensively studied, remain rather poorly known. This makes it all the more important to ensure that the later ones (1789, 1917) are as throughly studied as possible. The 1789 earthquake is listed by the current Italian catalogue (CPTI Working Group 2004) with Io VIII-IX MCS and Mm 5.8. These parameters were assessed from a database of 28 macroseismic intensity data points (Castelli et al. 1996), which is less than plentiful for a late 18th century earthquake. An analysis of the historical context of the 1789 earthquake and its influence on the production of contemporary accounts evidences a few research paths that previous studies either did not or could not take. Following them, the macroseismic database of the 1789 earthquake can be noticeably improved, providing the catalogue compiler with a mean to check the reliability of its current parameters.
    Description: Published
    Description: 249-260
    Description: 5.1. TTC - Banche dati e metodi macrosismici
    Description: open
    Keywords: Historical Seismicity ; 1789 Valtiberina Earthquake ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 11
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    Springer
    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/book
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  • 12
    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/book
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Nutrient cycling in agroecosystems 1 (1980), S. 177-190 
    ISSN: 1573-0867
    Keywords: winter wheat ; nitrogen uptake ; autumn dressing ; split-dressing ; growth ; grain yield ; protein content ; harvest-index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract A field experiment with the winter wheat cultivar Donata was carried out on a fine-textured river clay soil in 1978. The rates of nitrogen dressing ranged from 0 to 160 kg N per ha and were split over from one up to three application times: autumn, early spring and late spring. Total above-ground dry matter and grain dry-weight yields ranged from 9.1 to 13.7 tons per ha and from 4.17 to 6.35 tons per ha, respectively. Late top-dressings increased the harvest-index, whereas an autumn dressing had the opposite effect. Number of culms per m2, grain weight (mg) and grain number per m2 increased from 350 to 430, from 35.5 to 36.8 and from 11 680 to 16 980, respectively, as the nitrogen dosage was raised from 0 to 160 kg N per ha. The linear rate of grain growth ranged from 111 to 172 kg dry matter per ha per day with nitrogen doses from 0 to 160 kg N per ha. Differences in rate of grain growth per unit area were mainly related to number of grains per m2. The association between grain number and grain yield was reflected by a correlation coefficient of 0.97 (n = 32). A higher level of nitrogen dressing enhanced the leaf area index and leaf area duration. However, we could not derive an effect of nitrogen on the duration of grain growth. Total nitrogen yield ranged from 71 to 166 kg N per ha and grain nitrogen yield from 54 to 122 kg N per ha with nitrogen dosages of 0 and 160 kg N per ha, respectively. The nitrogen concentration of the grains varied between 1.3 and 2.0 N. An autumn dressing of 40 kg N per ha generally showed only minor effects on yield and yield components. Top dressings during spring resulted in a higher recovery and efficiency of the applied nitrogen. Therefore, it may be concluded from this experiment and literature that on fertile soils an autumn dressing of nitrogen will not be economical, but split-dressings in spring are very beneficial. In particular, a late nitrogen application during the boot stage increased grain number, harvest-index and grain yield as well as protein concentration of the grain.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 18 (1980), S. 321-326 
    ISSN: 1432-1041
    Keywords: sotalol ; hypertension ; renal impairment ; chronic administration ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten hypertensive patients with moderate to severe impairment of renal function were treated with sotalol for 5 to 10 weeks (average 6.4 weeks). Dosage was individually titrated (range 80 to 480 mg daily). The drug was given once daily in the morning. In eight patients blood pressure was satisfactorily controlled. Higher steady-state levels were observed than have been reported after similar doses in patients with normal renal function. The apparent first-order elimination rate constant and plasma clearance were significantly correlated with glomerular filtration rate. For an anuric patient, serum half-life was calculated to be 69 h. In relation to the raised plasma levels, side effects were uncommon. Since sotalol is excreted predominantly via the kidney, therapy in patients with impaired renal function should start with a low dose and any increase in dosage should be made carefully. As the anti-hypertensive effect does not appear to be correlated with the plasma level or with tolerance, adjustment of dose should be based on clinical response.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 18 (1980), S. 225-229 
    ISSN: 1432-1041
    Keywords: metoprolol ; hypertension ; slow-release preparations ; maximal exercise power ; fatigue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The treatment of hypertension with a single daily-dose of a beta-blocker gives rise to high peak-plasma concentrations 1.5 h after ingestion. After slow release-preparations of beta-blockers, the peak concentrations are half those produced by the conventional preparation at the same oral dose. A frequently occurring side-effect of beta-blocker therapy is fatigue. In this study the effect of a single dose of metoprolol 300 mg, 200 mg, 200 mg slow-release and a placebo on maximal exercise power was tested in 6 healthy subjects, 1.5 h and 24 h after ingestion. Maximal exercise power was significantly reduced 1.5 h after ingestion of metoprolol 300 mg and 200 mg. No change was found 1.5 h after 200 mg of a slow-release preparation. The possible reasons for reduced maximal exercise power are discussed. It is concluded that use of a beta-blocker for the treatment of hypertension in a single daily-dose regimen may be a reason to prefer a slow-release preparation.
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 18 (1980), S. 399-401 
    ISSN: 1432-1041
    Keywords: prazosin ; hypertension ; central monoaminergic neurons ; monoamine metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six hypertensive patients were treated with prazosin up to a final dose of 3–4.5 mg/day. There was a significant reduction of blood pressure. The cerebrospinal fluid (CSF) concentrations of the major metabolites of noradrenaline, dopamine and serotonin were unchanged. This indicates that the antihypertensive effect is not mediated via central monoaminergic neurons as suggested by animal studies.
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 18 (1980), S. 105-108 
    ISSN: 1432-1041
    Keywords: renin ; angiotensin ; aldosterone ; hypertension ; hypoaldosteronism ; pseudohypoaldosteronism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary There is increased activity of the renin, angiotensin, aldosterone (RAA) system in infancy and childhood. An inverse relationship between plasma renin, aldosterone and age has been demonstrated. In childhood hypertension due to renovascular disease or pyelonephritic scarring peripheral plasma renin is increased. Renal vein renin measurements in children with renal hypertension have proved valuable in predicting surgical curability of the underlying lesion. The upper limit of normal for the renal venous renin ratio in normotensive children without renal disease is 1.5. Pharmacological blockade of the RAA system has a place in diagnosis and treatment of hypertensive children. The plasma renin aldosterone profile is diagnostically useful in the investigation of salt-wasting disease and can easily distinguish between aldosterone biosynthetic defects and pseudohypoaldosteronism.
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 18 (1980), S. 135-139 
    ISSN: 1432-1041
    Keywords: hypertension ; labetalol ; propranolol ; renal haemodynamics ; glomerular filtration rate ; blood pressure ; exercise ; renal blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of exercise on renal haemodynamics was examined in young patients with mild essential hypertension. Four groups of subjects were studied: 13 normotensive, healthy control subjects, and 15 untreated, 11 propranolol-treated, and 6 labetalol-treated patients. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were measured during four consecutive periods, a pre-exercise control period, two exercise periods with loads of 450 kpm/min and 600 kpm/min, respectively, and a post-exercise control period. In the untreated patients RPF and GFR were lower during exercise than in the normotensive control subjects, whereas no significant differences were found at rest. In the propranolol-treated patients the reduction in RPF and GFR during exercise was more pronounced than in the untreated hypertensives. In the labetalol-treated patients however, RPF and GFR were reduced only to the same degree as in the untreated hypertensives. The reduced renal blood flow in propranolol-treated patients may be attributed to a compensatory increase in sympathetic activity caused by an impaired cardiac response to exercise. The lack of reduction in renal blood flow during labetalol therapy could partly be related to alpha-adrenergic blockade in the renal vascular bed induced by labetalol, and partly to the smaller reduction in cardiac output during labetalol than during propranolol therapy.
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 18 (1980), S. 231-235 
    ISSN: 1432-1041
    Keywords: molsidomine ; hypertension ; hypotension ; angina pectoris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Molsidomine (M), a new long-lasting antianginal compound, was studied in 38 hypertensive patients to assess its antihypertensive properties. Six patients were selected for an acute, single dose comparative trial with placebo over 8 h after treatment. The remaining 32 patients were used in a 1 month trial to study the effect on BP of more prolonged treatment. Systolic, diastolic and mean BP were significantly reduced after a single dose of M 4 mg, and the effect lasted for about 8 h. M also inhibited the hypertensive response to isometric exercise in handgrip tests performed 1 and 8 h after M ingestion. A dose-related decrease in systolic and diastolic BP in the one month trial was also observed. In addition to its antianginal properties, M appears to possess an interesting effect on BP in mildly to moderately hypertensive patients. A fall in BP is also a valuable effect in coronary patients with augmented metabolic demands of the heart.
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  • 20
    ISSN: 1432-1041
    Keywords: hypertension ; nifedipine ; beta-adrenoceptor blockade ; hypotensive action ; adverse effects ; combination therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antihypertensive effect of nifedipine (10–20 mg t.i.d.) given alone, or in combination with a beta-adrenoceptor blocking drug, was related to the observed plasma concentration during one dosage interval at steady-state (Pl-Nifss). The study was carried out as a within-patient comparison of treatment with nifedipine or placebo for 4 weeks. A highly significant reduction in blood pressure was obtained during monotherapy, as well as during combined treatment. The blood pressure reduction when nifedipine was added to beta-adrenoceptor blockade was of the same magnitude as that observed on nifedipine monotherapy. A considerable variation in Pl-Nifss was noted (range: 2–70 ng/ml). No significant correlation was found between the percentage reduction in blood pressure and Pl-Nifss in either of the two groups. There was a close relationship between Pl-Nifss and the concentration found 4 h after the morning dose. Side-effects were common during nifedipine monotherapy and were the reason for discontinuation of treatment in 4 of 18 patients. In contrast, none of the 9 patients on combined treatment dropped-out. In neither of the treatment groups was there any evidence for sodium retention and volume expansion during the first 4 weeks expressed as weight gain or signs of cardiac insufficiency. However, in 13 patients who continued on long-term treatment for 3–14 months, a definite need for concomitant diuretic therapy was found. The results indicate that nifedipine is effective in lowering blood pressure in patients with mild to moderate essential hypertension, either when given alone or in addition to beta-adrenoceptor blockade. It appears best tolerated as combination therapy. Long-term treatment requires addition of a diuretic. Pl-Nifss did not seem to be a major determinant of the magnitude of the hypotensive response.
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  • 21
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    European journal of clinical pharmacology 18 (1980), S. 375-382 
    ISSN: 1432-1041
    Keywords: calcium antagonist ; verapamil ; hypertension ; vasodilators ; plasma renin activity ; mode of action ; sodium balance ; fluid balance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 12 in-patients with moderate uncomplicated hypertension, maintained on constant sodium intake for 15 days, single-blind oral administration of verapamil 80–160 mg t. i. d. for 10 days had a significant antihypertensive effect: in the supine position systolic blood pressure decreased from 177±5 to 150±3 mmHg, and diastolic pressure from 111±3 to 96±2 mmHg; standing values were similarly lowered from 171±7 to 143±4 mmHg, systolic, and from 118±4 to 97±2 mmHg, diastolic. The heart rate did not show any significant change (from 79±3 to 77±2 beats/min, supine, and from 92±3 to 87±3 beats/min, upright). The antihypertensive effect was uniform throughout the day, being similar 2, 3, 6 and 8 h after administration of a dose. Dynamic exercise (75–100 watts on a cycle-ergometer) caused identical increases in arterial pressure and heart rate on the last day of placebo and again on the last day with verapamil, but the peak levels of systolic pressure reached during exercise were lower after verapamil than with placebo, because of the lower blood pressure before exercise. Reduction of arterial pressure by verapamil was not accompanied by increased plasma renin activity, or by renal retention of sodium and water: there was a small increase in sodium excretion, at least during the first days of verapamil administration (from 107±15 to 113±15 mEq Na+/day), and a slight significant reduction in body weight (from 74.2±3.7 to 73.5±3.7 kg). It is concluded that oral administration of verapamil significantly lowers blood pressure without simultaneously inducing cardiac stimulation, renin secretion or salt and water retention.
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  • 22
    ISSN: 1432-1041
    Keywords: atenolol ; hypertension ; plasma renin activity ; pharmacokinetics ; pharmacodynamic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To show whether repeated administration of atenolol for several days would influence its pharmacokinetic parameters and the extent and duration of the pharmacologic responses, the plasma level of atenolol and changes in heart rate, blood pressure and plasma renin activity were measured in 12 hypertensive patients at various times of day (9 a. m., 12 noon, 3 p. m. and 7 p. m.) after oral administration of the first dose of atenolol 100 mg, again during the 7th and 14th days of continued once-daily administration of the same dose, and finally during the three days following withdrawal of the drug. The peak plasma concentration of atenolol (about 600 ng/ml) was found 3 h after administration of the first dose, and measurable amounts (50–70 ng/ml) were found after 24 h. None of the pharmacokinetic characteristics were changed by administration of a single daily dose for two weeks. After withdrawal of the drug, detectable amounts of atenolol were found in plasma for at least 48 h. The first dose of atenolol caused prompt (3 h) and prolonged (up to 24 h) lowering of supine and standing systolic and diastolic blood pressures, slowing of supine and standing heart rate, reduction of the blood pressure and heart rate responses to dynamic exercise, and a decrease in plasma renin activity. The extent and time-course of all these responses were not influenced by repeated once-daily administration of the 100 mg dose for two weeks. Most of the effects continued during the withdrawal days, the lowering of blood pressure being somewhat more prolonged than the slowing of heart rate. It is concluded that a once-daily dose of atenolol 100 mg decreases blood pressure and heart rate throughout the following 24 h, without excessive daily fluctuation in its effects, and without signs of tolerance or accumulation.
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  • 23
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    European journal of clinical pharmacology 17 (1980), S. 239-241 
    ISSN: 1432-1041
    Keywords: timolol ; hypertension ; dose ranging ; double-blind trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nine previously untreated patients with mild-moderate hypertension were included in a dose-ranging double-blind trial to determine the effectiveness of daily versus thrice daily timolol administration. In 8 patients control of blood pressure was equally effective though with significantly lower heart rate achieved in the once daily group. One patient was not satisfactorily controlled on the daily regimen demonstrating that many but not all hypertensives can be controlled with daily administration of timolol.
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  • 24
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    European journal of clinical pharmacology 18 (1980), S. 391-394 
    ISSN: 1432-1041
    Keywords: propranolol ; hypertension ; beta-adrenergic blockade ; exercise heart rate ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of propranolol in 16 hypertensive patients was compared after the first oral dose of 80 mg and during chronic treatment with 80 mg bd. The degree of beta-adrenergic blockade was estimated by the reduction in maximal exercise heart rate. No significant change in plasma half-life occurred and there was no correlation between the mean steady-state propranolol concentration and beta-adrenergic blockade or antihypertensive effect. A linear relationship was observed between the decrease in blood pressure and the reduction in heart rate during maximal exercise. Therefore, the antihypertensive effect of propranolol can be explained by its peripheral beta-adrenergic blocking properties.
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  • 25
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    European journal of clinical pharmacology 17 (1980), S. 329-332 
    ISSN: 1432-1041
    Keywords: reserpine ; hydrochlorothiazide ; pituitary hormones ; gonadal hormones ; hypertension ; serum concentration ; antihypertensive therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Sex histories and serum samples were obtained from 27 hypertensive men before and after 3 months of therapy with either 100 mg of hydrochlorothiazide or 0.25 mg of reserpine daily. Sera were analyzed for testosterone, dihydrotestosterone, estradiol, luteinizing hormone and prolactin. Both drugs effectively lowered blood pressure. The incidence of impaired sexual performance was low and insignificantly different in the two treatment groups. There were no significant changes in serum hormone concentrations as a result of drug therapy.
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  • 26
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    European journal of clinical pharmacology 17 (1980), S. 409-413 
    ISSN: 1432-1041
    Keywords: penbutolol ; hypertension ; propranolol ; double-blind crossover comparison ; blood pressure ; heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Penbutolol is a potent long-acting non-cardioselective beta-adrenergic blocker with partial agonist activity. A double-blind cross-over comparison of penbutolol given in a single daily dose and propranolol given twice daily in the treatment of ambulant patients with moderate hypertension is described. Fourteen patients completed the study and were treated with each drug for 12 weeks. Penbutolol in daily doses of 20–120 mg and propranolol in daily doses of 80–400 mg produced similar significant reductions in both supine and erect blood pressure. Penbutolol did not reduce heart rate to the same extent as propranolol, in equivalent doses. Penbutolol appears to produce adequate control of moderate hypertension when administered once a day, and this effect appears to be equivalent to divided doses of propranolol. No serious adverse effects were reported, although one patient receiving penbutolol experienced severe eye pains at a dose of 40 mg which resolved on crossing over to treatment with propranolol.
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  • 27
    ISSN: 1432-1041
    Keywords: papaverine ; propranolol ; pindolol ; hypertension ; isoprenaline ; haemodynamic effects ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of two β-adrenoceptor antagonists, propranolol and pindolol, on the haemodynamic effects of papaverine, isoprenaline and noradrenaline was investigated in 9 male patients with first degree essential hypertension. Propranolol and pindolol were given according to a doubleblind, crossover scheme. Heart rate and blood pressure were measured before and after each treatment. Propranolol 670 µg/kg i. v. reduced the supine and standing systolic blood pressures by 2.3% and 1.6%, respectively. Similarly, the intravenous administration of pindolol 35 µg/kg reduced supine and standing systolic blood pressure by 5.5% and 8.3% respectively (clinically insignificant). Neither drug affected diastolic blood pressure. Following propranolol, there were moderate reductions in supine and standing heart rates, respectively by 24% and 20% (p〈0.001). Similarly, but to a lesser extent, pindolol reduced supine and standing heart rate by 12% and 17% (p〈0.001). The effects of papaverine, which, at 1.5 mg/kg i. v. reduced systolic blood pressure by 5–10% and increased heart rate by 8–15%, were not significantly influenced by the β-blockers. The blood pressure and heart rate responses to isoprenaline, on the other hand, were attenuated or inhibited by both β-blockers. While the β-blockers inhibited the β-adrenoceptor component of noradrenaline, the pressor component of noradrenaline, which is mediated through the α-adrenoceptors, was not influenced by propranolol, but was inhibited after pindolol. It is concluded that pindolol differs qualitatively from propranolol in that it inhibited both the α-and β-adrenoceptor effects of noradrenaline.
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  • 28
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    European journal of clinical pharmacology 17 (1980), S. 321-328 
    ISSN: 1432-1041
    Keywords: metoprolol ; hypertension ; pharmacokinetics ; plasma renin ; blood pressure effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eleven patients were treated for essential hypertension with metoprolol (Selokén®) for more than three months. The time course of changes in blood pressure, pulse rate and plasma renin activity was studied during treatment with an oral maintenance dose of 100 mg twice daily. Significant decreases in pulse rate, diastolic blood pressure and plasma renin activity were observed even after the first dose. The plasma concentration of metoprolol reached equilibrium after the second dose. After the third dose there was no further significant change in blood pressure. There was a significant correlation (p〈0.001) between the initial (after three doses) and final (after 〉90days) effect of metoprolol on blood pressure (r=0.86 and 0.91 for systolic and diastolic blood pressure change, respectively).
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  • 29
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    European journal of clinical pharmacology 17 (1980), S. 161-164 
    ISSN: 1432-1041
    Keywords: nifedipine ; hypertension ; blood pressure ; heart rate ; plasma renin activity ; aldosterone ; clinical trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The magnitude and duration of the antihypertensive effect of nifedipine were studied in 7 cases of moderate essential hypertension. In a double-blind crossover study, nifedipine 10 mg or a placebo were administered sublingually 4 times a day for 2 days, and the results were compared. Each dose of nifedipine reduced systolic and diastolic blood pressure by 14% both in the supine and upright positions. The antihypertensive action lasted for about 3 h and it was not cumulative. The reduction in blood pressure was associated with a temporary increase in heart rate. Administration of nifedipine 10 mg did not significantly raise plasma renin activity or plasma aldosterone. The drug was well tolerated and no side effects were detected.
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  • 30
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    European journal of clinical pharmacology 17 (1980), S. 333-337 
    ISSN: 1432-1041
    Keywords: atenolol ; chlorthalidone ; hypertension ; chronic treatment ; co-administration ; plasma half-life ; urine half-life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of atenolol with and without the co-administration of chlorthalidone were studied in five hypertensive subjects. Concomitant administration of chlorthalidone appears to have little if any effect on the pharmacokinetics of atenolol during treatment for 7 days. The atenolol elimination half-lives were 6.7±1.1 and 6.3±0.9 h, respectively, with and without chlorthalidone. Two healthy volunteers also received a single 50 mg oral dose of chlorthalidone. Their blood profiles and pharmacokinetics were similar to those observed in hypertensive subjects, but a statistically significant difference (p〈0.01) was found between the urinary excretion half-lives of chlorthalidone. This difference may be because chronic administration of the drug caused saturation of red cell binding.
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  • 31
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    Biochemical genetics 18 (1980), S. 353-364 
    ISSN: 1573-4927
    Keywords: carboxylesterase ; electrophoretic variants ; fish development ; gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Two esterases splitting α-naphthylacetate have been found in the tissues of adult loaches and in embryos. These were identified as arylesterase (E-1) (arylester hydrolase, E.C. 3.1.1.2) and carboxylesterase (E-2) (carboxylic ester hydrolase, E.C. 3.1.1.1.). In unfertilized loach eggs E-1 and E-2 synthesized during oogenesis were found. Active E-2 synthesized under the control of E-2 genes of the embryo appeared in embryos from the stage of 40–50 h of development. Maternal E-2 molecules synthesized in oogenesis or on the stored templates in embryogenesis persisted in larvae up to days 5–6 of development. Two genes controlling the synthesis of two forms of E-2 differing in electric mobility were found in the loach population from the delta of the Danube. The genes for fast and slow E-2 were shown to segregate in meiosis and to be allelic.
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  • 32
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    Bulletin of experimental biology and medicine 90 (1980), S. 1082-1085 
    ISSN: 1573-8221
    Keywords: hypertension ; adrenalectomy ; fat cells ; isoproterenol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
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  • 33
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    Hydrobiologia 72 (1980), S. 125-129 
    ISSN: 1573-5117
    Keywords: Phytoplankton ; respiration ; photosynthesis ; growth ; feedback mechanism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In the eutrophic Bautzen reservoir (German Democratic Republic) the compensation light intensities (photosynthesis = respiration of the phytoplankton) have been found to be extremely low if no free carbon dioxide is available. This result is interpreted as a minimization of the cell respiration under CO2-limitation of the photosynthesis.
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  • 34
    ISSN: 1573-5117
    Keywords: Salamandra ; Urodela ; metamorphosis ; growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Salamandra salamandra larvae originating from a single batch (layed by one female) were raised at different temperatures and on ion-rich or distilled water. Temperature, but not the presence or absence of ions affected growth. Larvae originating from one batch or from several batches born on the same day, were kept without food for long periods of several months in order to observe cannibalistic predation under such conditions. This phenomenon is known in natural populations of salamanders inhabitating either rain pools in rocks or permanent springs poor in aquatic life. It was found that cannibalism increased under experimental conditions proportionally to the increase in size between the larvae.
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    Hydrobiologia 70 (1980), S. 37-38 
    ISSN: 1573-5117
    Keywords: blue-green algae ; Alloxan ; growth ; pigments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Effect of Alloxan was studied on a nitrogen-fixing blue-green alga: Westiellopsis prolifica in pure cultures. Concentrations of Alloxan, 10 μg to 50 μg/ml stimulate the growth of the alga and increase the chlorophyll, carotin and phycocyanin content of the cultures.
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  • 36
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    Hydrobiologia 71 (1980), S. 87-93 
    ISSN: 1573-5117
    Keywords: Chara ; rubidium ; caesium ; requirement of nutrients ; growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Résumé Le rubidium et le césium introduits à l'état de chlorure dans le milieu de culture ont à faible dose un effet stimulant sur la croissance de Chara fragilis et de Chara vulgaris. La résistance de ces végétaux à l'action toxique des deux ions est accrue par l'addition de potassium au milieu. Les analyses chimiques confirment que le rubidium et le césium sont antagonistes vis-à-vis du potassium et du sodium alors qu'ils ne modifient pas de manière significative le taux de calcium.
    Notes: Abstract Chara fragilis and Chara vulgaris were cultivated in a natural medium containing rubidium and caesium as chloride. The growth of Characeae was increased after culture in the solutions containing Rb and Cs in small amount. The resistance to the toxic effects of these two ions is enhanced if potassium chloride is added to the medium. Quantitative analyses indicate that Rb and Cs decrease the rate of Na and K but have no significative influence on the rate of Ca.
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  • 37
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    Bulletin of experimental biology and medicine 90 (1980), S. 1510-1513 
    ISSN: 1573-8221
    Keywords: adaptation ; hemorrhage ; hypotension ; hypertension ; reinfusion
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    Topics: Biology , Medicine
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  • 38
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    Bulletin of experimental biology and medicine 90 (1980), S. 1591-1593 
    ISSN: 1573-8221
    Keywords: electromagnetic field ; fluctuation ; growth ; carcinogenesis
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